EP3730138A4 - Arzneimittel mit kombination aus sepetaprost und rho-kinase-inhibitor - Google Patents

Arzneimittel mit kombination aus sepetaprost und rho-kinase-inhibitor Download PDF

Info

Publication number
EP3730138A4
EP3730138A4 EP18891292.7A EP18891292A EP3730138A4 EP 3730138 A4 EP3730138 A4 EP 3730138A4 EP 18891292 A EP18891292 A EP 18891292A EP 3730138 A4 EP3730138 A4 EP 3730138A4
Authority
EP
European Patent Office
Prior art keywords
sepetaprost
rho
medicament
combination
kinase inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP18891292.7A
Other languages
English (en)
French (fr)
Other versions
EP3730138A1 (de
EP3730138B1 (de
Inventor
Yasuko Yamamoto
Takazumi Taniguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Santen Pharmaceutical Co Ltd
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Priority to EP24153812.3A priority Critical patent/EP4338751A3/de
Publication of EP3730138A1 publication Critical patent/EP3730138A1/de
Publication of EP3730138A4 publication Critical patent/EP3730138A4/de
Application granted granted Critical
Publication of EP3730138B1 publication Critical patent/EP3730138B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP18891292.7A 2017-12-21 2018-12-20 Kombination von sepetaprost und ripasudil zur verwendung in der prophylaxe oder behandlung von glaukom oder okulärer hypertension Active EP3730138B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP24153812.3A EP4338751A3 (de) 2017-12-21 2018-12-20 Arzneimittel mit einer kombination aus sepetaprost und rho-assoziiertem coiled-coil mit einem proteinkinasehemmer

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2017244847 2017-12-21
JP2018180658 2018-09-26
PCT/JP2018/046970 WO2019124488A1 (ja) 2017-12-21 2018-12-20 セペタプロストとＲｈｏキナーゼ阻害剤との組み合わせ医薬

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP24153812.3A Division EP4338751A3 (de) 2017-12-21 2018-12-20 Arzneimittel mit einer kombination aus sepetaprost und rho-assoziiertem coiled-coil mit einem proteinkinasehemmer

Publications (3)

Publication Number Publication Date
EP3730138A1 EP3730138A1 (de) 2020-10-28
EP3730138A4 true EP3730138A4 (de) 2021-08-25
EP3730138B1 EP3730138B1 (de) 2024-02-14

Family

ID=66993448

Family Applications (2)

Application Number Title Priority Date Filing Date
EP24153812.3A Pending EP4338751A3 (de) 2017-12-21 2018-12-20 Arzneimittel mit einer kombination aus sepetaprost und rho-assoziiertem coiled-coil mit einem proteinkinasehemmer
EP18891292.7A Active EP3730138B1 (de) 2017-12-21 2018-12-20 Kombination von sepetaprost und ripasudil zur verwendung in der prophylaxe oder behandlung von glaukom oder okulärer hypertension

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP24153812.3A Pending EP4338751A3 (de) 2017-12-21 2018-12-20 Arzneimittel mit einer kombination aus sepetaprost und rho-assoziiertem coiled-coil mit einem proteinkinasehemmer

Country Status (9)

Country Link
US (2) US11446273B2 (de)
EP (2) EP4338751A3 (de)
JP (2) JPWO2019124488A1 (de)
KR (1) KR20200103042A (de)
CN (1) CN111479568A (de)
CA (1) CA3086457A1 (de)
ES (1) ES2972934T3 (de)
TW (2) TWI788484B (de)
WO (1) WO2019124488A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111217834B (zh) * 2020-02-21 2021-10-26 维眸生物科技（上海）有限公司 Rock激酶抑制剂的硝基氧衍生物

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0286903B2 (de) 1987-04-03 2000-03-29 The Trustees Of Columbia University In The City Of New York Anwendung eines Prostaglandins in Mischung mit einem adrenergischen Blocker zur Verminderung des Augen-Innendruckes
US4952581A (en) 1987-04-03 1990-08-28 The Trustees Of Columbia University In The City Of New York Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocular pressure
AU720326B2 (en) 1995-12-21 2000-05-25 Alcon Laboratories, Inc. Use of certain isoquinolinesulfonyl compounds for the treatment of glaucoma and ocular ischemia
CA2263425C (en) 1996-08-12 2008-09-30 Yoshitomi Pharmaceutical Industries Ltd. Pharmaceutical agent containing rho kinase inhibitor
JP4212149B2 (ja) 1998-06-11 2009-01-21 株式会社デ・ウエスタン・セラピテクス研究所 医薬
AU5198199A (en) 1998-08-17 2000-03-06 Senju Pharmaceutical Co., Ltd. Preventives/remedies for glaucoma
US7217722B2 (en) 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
JP4342704B2 (ja) 2000-07-21 2009-10-14 富士フイルム株式会社 液晶分子の配向方法
US20030018079A1 (en) 2000-11-13 2003-01-23 Richardson Helene Treatment
HN2002000067A (es) 2001-03-23 2003-10-24 Bayer Healthcare Llc Inhibidores de la rho - quinasa.
TWI336328B (en) 2001-03-23 2011-01-21 Bayer Healthcare Llc Rho-kinase inhibitors
WO2002100833A1 (fr) 2001-06-12 2002-12-19 Sumitomo Pharmaceuticals Company, Limited Inhibiteurs de rho kinase
JP4017921B2 (ja) 2002-06-12 2007-12-05 高砂熱学工業株式会社 暖房室内の空気循環装置
JP4128038B2 (ja) 2002-07-10 2008-07-30 富士フイルム株式会社 電子ペーパー
JP4482726B2 (ja) * 2002-08-29 2010-06-16 参天製薬株式会社 Ｒｈｏキナーゼ阻害剤とプロスタグランジン類からなる緑内障治療剤
AU2003257588A1 (en) 2002-08-29 2004-03-19 Santen Pharmaceutical Co., Ltd. REMEDY FOR GLAUCOMA COMPRISING Rho KINASE INHIBITOR AND PROSTAGLANDINS
WO2004045644A1 (ja) 2002-11-18 2004-06-03 Santen Pharmaceutical Co., Ltd. Rhoキナーゼ阻害剤とβ遮断薬からなる緑内障治療剤
TWI367098B (en) 2004-12-23 2012-07-01 Kowa Co Treating agent for glaucoma
EP1792622A1 (de) * 2005-11-11 2007-06-06 GPC Biotech AG Antiproliferative Kombinationstherapie mit einem Platin enthaltenden chemotherapeutischen Mittel und EGFR-Inhibitoren oder Pyrimidinanaloga
EP2127638A1 (de) * 2008-05-30 2009-12-02 Santen Pharmaceutical Co., Ltd Verfahren und Zusammensetzung zur Behandlung von Augenhochdruck und Glaukom
JP2011530511A (ja) * 2008-08-05 2011-12-22 メルク・シャープ・エンド・ドーム・コーポレイション 治療用化合物
JP2010113957A (ja) 2008-11-06 2010-05-20 Ntt Docomo Inc コネクタ
HUE026742T2 (en) 2009-03-30 2016-07-28 Ube Industries A pharmaceutical composition for the treatment or prevention of glaucoma
JP2012525386A (ja) 2009-05-01 2012-10-22 アエリエ・ファーマシューティカルズ・インコーポレーテッド 疾患の治療のための二重機構阻害剤
JP2011013651A (ja) 2009-07-03 2011-01-20 Mitsumasa Maeda フレキシブルディスプレイのれん
EP2460801B1 (de) 2009-07-28 2014-06-25 ONO Pharmaceutical Co., Ltd. Bizyklische verbindung und ihre verwendung für medizinische zwecke
US9029574B2 (en) 2011-01-27 2015-05-12 Ono Pharmaceutical Co., Ltd. Bicyclic compound and use thereof for medical purposes
ES2684351T3 (es) * 2011-02-04 2018-10-02 Kowa Co., Ltd. Terapia farmacológica para prevenir o tratar glaucoma

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
EYDIE MILLER ELLIS ET AL: "Ocular hypotensive effect of the novel EP3/FP agonist ONO-9054 versus Xalatan: results of a 28-day, double-masked, randomised study", BRITISH JOURNAL OF OPHTHALMOLOGY, vol. 101, no. 6, 20 September 2016 (2016-09-20), GB, pages 796 - 800, XP055538363, ISSN: 0007-1161, DOI: 10.1136/bjophthalmol-2016-309023 *
LEWIS RICHARD A ET AL: "Fixed-dose combination of AR-13324 and latanoprost: a double-masked, 28-day, randomised, controlled study in patients with open-angle glaucoma or ocular hypertension", BRITISH JOURNAL OF OPHTHALMOLOGY, vol. 100, no. 3, 1 March 2016 (2016-03-01), GB, pages 339 - 344, XP055824829, ISSN: 0007-1161, DOI: 10.1136/bjophthalmol-2015-306778 *
LOUISE J LU ET AL: "Novel Pharmacologic Candidates for Treatment of Primary Open-Angle Glaucoma", THE YALE JOURNAL OF BIOLOGY AND MEDICINE, vol. 90, no. 1, 1 March 2017 (2017-03-01), US, pages 111 - 118, XP055765723, ISSN: 0044-0086 *

Also Published As

Publication number Publication date
WO2019124488A1 (ja) 2019-06-27
CA3086457A1 (en) 2019-06-27
ES2972934T3 (es) 2024-06-17
US11446273B2 (en) 2022-09-20
EP4338751A2 (de) 2024-03-20
US20220387372A1 (en) 2022-12-08
TWI833535B (zh) 2024-02-21
EP3730138A1 (de) 2020-10-28
CN111479568A (zh) 2020-07-31
TW201927298A (zh) 2019-07-16
EP3730138B1 (de) 2024-02-14
KR20200103042A (ko) 2020-09-01
TW202320747A (zh) 2023-06-01
JP2023110030A (ja) 2023-08-08
US20200316009A1 (en) 2020-10-08
EP4338751A3 (de) 2024-05-22
JPWO2019124488A1 (ja) 2020-12-17
TWI788484B (zh) 2023-01-01

Similar Documents

Publication Publication Date Title
EP3700527A4 (de) Papd5-inhibitoren und verfahren zur verwendung davon
EP3684361A4 (de) Substituierte inhibitoren von menin-mll und verfahren zur verwendung
IL276095A (en) gcn2 inhibitors and their uses
EP3703806A4 (de) Hämostasevorrichtungen und verfahren zur verwendung
IL276147A (en) GCN2 inhibitors and uses thereof
EP3658557A4 (de) Tyk2-inhibitoren und verwendungen davon
EP3429591A4 (de) Substituierte inhibitoren von menin-mll und verfahren zur verwendung
EP3307728A4 (de) Kombinationstherapie von transkriptionshemmern und kinasehemmern
EP3471727A4 (de) Cxcr4-inhibitoren und verwendungen davon
EP3454945A4 (de) Ash11-inhibitoren und verfahren zur behandlung damit
EP3389658A4 (de) Glycosidasehemmer und verwendungen davon
EP3472129A4 (de) Cxcr4-inhibitoren und verwendungen davon
EP3510040A4 (de) Ektonukleotidasehemmer und verfahren zur verwendung davon
EP3670513A4 (de) Fgfr-inhibitor und medizinische anwendung davon
EP3558998A4 (de) Ektonukleotidasehemmer und verfahren zur verwendung davon
EP3548683A4 (de) Anordnung zur umkippvorbeugung eines möbelstücks und möbelstück mit solch einer anordnung
EP3589319A4 (de) Glycaninteragierende verbindungen und verfahren zur verwendung
EP3281942A4 (de) B-lactamase-hemmer und verwendung davon
EP3471726A4 (de) Cxcr4-inhibitoren und verwendungen davon
EP3572400A4 (de) Ezh2-inhibitor und verwendung davon
LT3532459T (lt) Lsd1 inhibitoriai ir jų medicininis panaudojimas
EP3592731A4 (de) Inhibitoren von malt1 und verwendungen davon
EP3710430A4 (de) Acss2-hemmer und verfahren zur verwendung
EP3681499A4 (de) Verbindungen als ras-inhibitoren und ihre verwendung
EP3706737A4 (de) Ash11-inhibitoren und verfahren zur behandlung damit

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20200702

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40029829

Country of ref document: HK

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20210726

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/558 20060101AFI20210720BHEP

Ipc: A61K 31/335 20060101ALI20210720BHEP

Ipc: A61K 31/472 20060101ALI20210720BHEP

Ipc: A61K 31/551 20060101ALI20210720BHEP

Ipc: A61K 45/00 20060101ALI20210720BHEP

Ipc: A61P 9/12 20060101ALI20210720BHEP

Ipc: A61P 27/02 20060101ALI20210720BHEP

Ipc: A61P 27/06 20060101ALI20210720BHEP

Ipc: A61P 43/00 20060101ALI20210720BHEP

REG Reference to a national code

Ref country code: DE

Ref document number: 602018065361

Country of ref document: DE

Ref legal event code: R079

Free format text: PREVIOUS MAIN CLASS: A61K0031335000

Ipc: A61K0031558000

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 45/06 20060101ALI20230313BHEP

Ipc: A61K 31/335 20060101ALI20230313BHEP

Ipc: A61K 31/472 20060101ALI20230313BHEP

Ipc: A61K 45/00 20060101ALI20230313BHEP

Ipc: A61P 9/12 20060101ALI20230313BHEP

Ipc: A61P 27/02 20060101ALI20230313BHEP

Ipc: A61P 27/06 20060101ALI20230313BHEP

Ipc: A61P 43/00 20060101ALI20230313BHEP

Ipc: A61K 31/551 20060101ALI20230313BHEP

Ipc: A61K 31/558 20060101AFI20230313BHEP

INTG Intention to grant announced

Effective date: 20230406

GRAJ Information related to disapproval of communication of intention to grant by the applicant or resumption of examination proceedings by the epo deleted

Free format text: ORIGINAL CODE: EPIDOSDIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTC Intention to grant announced (deleted)
INTG Intention to grant announced

Effective date: 20230913

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20231220

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602018065361

Country of ref document: DE

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG9D

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2972934

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20240617

REG Reference to a national code

Ref country code: NL

Ref legal event code: MP

Effective date: 20240214