EP3704528C0 - Abbildungssysteme mit mikrooptischen elementarrays und verfahren zur probenabbildung - Google Patents

Abbildungssysteme mit mikrooptischen elementarrays und verfahren zur probenabbildung

Info

Publication number
EP3704528C0
EP3704528C0 EP18807215.1A EP18807215A EP3704528C0 EP 3704528 C0 EP3704528 C0 EP 3704528C0 EP 18807215 A EP18807215 A EP 18807215A EP 3704528 C0 EP3704528 C0 EP 3704528C0
Authority
EP
European Patent Office
Prior art keywords
micro
element optical
optical arrays
imaging
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP18807215.1A
Other languages
English (en)
French (fr)
Other versions
EP3704528A2 (de
EP3704528B1 (de
Inventor
Etienne Shaffer
Bastien Rachet
Aurèle Timothée Horisberger
Jonathan Abel Pirolet
Diego Joss
Andrey Naumenko
Frédéric Schmitt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Samantree Medical Switzerland Sa
Original Assignee
Samantree Medical Switzerland Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samantree Medical Switzerland Sa filed Critical Samantree Medical Switzerland Sa
Publication of EP3704528A2 publication Critical patent/EP3704528A2/de
Application granted granted Critical
Publication of EP3704528C0 publication Critical patent/EP3704528C0/de
Publication of EP3704528B1 publication Critical patent/EP3704528B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/20—Surgical microscopes characterised by non-optical aspects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/0012—Surgical microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0036—Scanning details, e.g. scanning stages
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/008—Details of detection or image processing, including general computer control
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G02B21/08—Condensers
    • G02B21/082—Condensers for incident illumination only
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/56—Cameras or camera modules comprising electronic image sensors; Control thereof provided with illuminating means
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N7/00—Television systems
    • H04N7/18—Closed-circuit television [CCTV] systems, i.e. systems in which the video signal is not broadcast
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Multimedia (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Signal Processing (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
EP18807215.1A 2017-10-31 2018-10-31 Abbildungssysteme mit mikrooptischen elementarrays und verfahren zur probenabbildung Active EP3704528B1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201762579827P 2017-10-31 2017-10-31
US201762597346P 2017-12-11 2017-12-11
US201862675368P 2018-05-23 2018-05-23
US201862675638P 2018-05-23 2018-05-23
US16/146,695 US10539776B2 (en) 2017-10-31 2018-09-28 Imaging systems with micro optical element arrays and methods of specimen imaging
PCT/EP2018/079894 WO2019086550A2 (en) 2017-10-31 2018-10-31 Imaging systems with micro optical element arrays and methods of specimen imaging

Publications (3)

Publication Number Publication Date
EP3704528A2 EP3704528A2 (de) 2020-09-09
EP3704528C0 true EP3704528C0 (de) 2025-12-10
EP3704528B1 EP3704528B1 (de) 2025-12-10

Family

ID=66328459

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18807215.1A Active EP3704528B1 (de) 2017-10-31 2018-10-31 Abbildungssysteme mit mikrooptischen elementarrays und verfahren zur probenabbildung

Country Status (3)

Country Link
US (4) US10539776B2 (de)
EP (1) EP3704528B1 (de)
WO (1) WO2019086550A2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3278166A2 (de) 2015-03-31 2018-02-07 Samantree Medical SA Systeme und verfahren zur bildgebung im operationssaal von frischem, während der operation zur pathologischen beurteilung reseziertem gewebe
CA177629S (en) * 2017-04-13 2019-02-06 Hamamatsu Photonics Kk Digital slide scanner
US11747603B2 (en) * 2017-10-31 2023-09-05 Samantree Medical Sa Imaging systems with micro optical element arrays and methods of specimen imaging
US10928621B2 (en) 2017-10-31 2021-02-23 Samantree Medical Sa Sample dishes for use in microscopy and methods of their use
US10539776B2 (en) 2017-10-31 2020-01-21 Samantree Medical Sa Imaging systems with micro optical element arrays and methods of specimen imaging
WO2019231298A1 (ko) * 2018-05-31 2019-12-05 (주) 솔 영상 기반의 대면적 시료 분석 장치, 매질 특성 차이를 이용한 영상 기반의 시료 분석 장치 및 이를 이용하여 시료를 측정하고 분석하는 방법
US20200309649A1 (en) * 2019-03-08 2020-10-01 Samantree Medical Sa Receptacles for staining and/or rinsing samples and methods of their use
CN110108690B (zh) * 2019-06-10 2023-11-24 中国科学院生物物理研究所 一种超低温可换样显微成像系统及其工作方法
US10921721B1 (en) 2019-09-13 2021-02-16 Applied Materials, Inc. Measurement system and grating pattern array
CN111375136B (zh) * 2019-10-09 2021-12-28 鲍玉珍 太赫兹波理疗终端、用于早中期乳腺癌的太赫兹波理疗系统
WO2021146201A1 (en) * 2020-01-13 2021-07-22 Arizona Board Of Regents On Behalf Of The University Of Arizona Optical biopsy stain panels and methods of use
US11467676B2 (en) * 2020-02-06 2022-10-11 Key Ovation, Llc Computer keyboard with electronically changeable keycaps
CN115335747A (zh) 2020-02-12 2022-11-11 萨曼萃医疗公司 用于以减少的样本运动伪影对样本进行成像的系统和方法
CN111413342B (zh) * 2020-04-20 2021-03-26 华中科技大学 一种冰冻切片显微成像系统
CN111654667A (zh) * 2020-05-25 2020-09-11 刘彦杰 一种具有防进水功能的楼宇对讲机
EP4264231A4 (de) * 2020-12-16 2024-11-13 Singular Genomics Systems, Inc. Kinematisches abbildungssystem
WO2023012241A1 (en) 2021-08-04 2023-02-09 Samantree Medical Sa Systems and methods for providing live sample monitoring information with parallel imaging systems
WO2023211772A1 (en) * 2022-04-25 2023-11-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Lens array based imaging system with improved field of view
CN115576082B (zh) * 2022-12-08 2023-04-11 中国科学院西安光学精密机械研究所 用于极端照度环境的远距离大幅宽成像系统
CN117590616A (zh) * 2023-11-29 2024-02-23 福建福光股份有限公司 一种微透镜阵列与红外探测器的集成对位方法及辅助装置
TWI898377B (zh) * 2023-12-29 2025-09-21 致茂電子股份有限公司 微型投影裝置的檢測設備及檢測方法

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3814504A (en) 1972-04-28 1974-06-04 Universal Technology Reflecting lens array
US4927254A (en) 1987-03-27 1990-05-22 The Board Of Trustees Of The Leland Stanford Junior University Scanning confocal optical microscope including an angled apertured rotating disc placed between a pinhole and an objective lens
US4835380A (en) 1987-06-11 1989-05-30 U. S. Philips Corporation Scanning device for an optical recording and/or reproducing apparatus
US5257128A (en) 1988-06-22 1993-10-26 Board Of Regents, The University Of Texas System Freezing/perfusion microscope stage
CA1325537C (en) 1988-08-01 1993-12-28 Timothy Peter Dabbs Confocal microscope
US5580827A (en) 1989-10-10 1996-12-03 The Board Of Trustees Of The Leland Stanford Junior University Casting sharpened microminiature tips
DE4300698A1 (de) 1993-01-13 1994-07-14 Raimund Schuetze Vorrichtung und Verfahren zur Handhabung, Bearbeitung und Beobachtung kleiner Teilchen, insbesondere biologischer Teilchen
US5463223A (en) 1994-01-24 1995-10-31 Patwong Technologies, Inc. Disposable all purpose micro sample holder
US5557452A (en) 1995-02-06 1996-09-17 University Of Hawaii Confocal microscope system
GB9509487D0 (en) 1995-05-10 1995-07-05 Ici Plc Micro relief element & preparation thereof
EP0991959B1 (de) 1996-02-28 2004-06-23 Kenneth C. Johnson Mikrolinsen-rastereinrichtung für mikrolithografie und für konfokale mikroskopie mit grossem aufnahmefeld
DE19632594A1 (de) 1996-08-13 1998-02-19 Johannes Prof Dr Schwider Konfokales Mikroskop unter Anwendung von refraktiven Mikrolinsen-Feldern
US6424852B1 (en) 1996-10-18 2002-07-23 Lucid, Inc. System for confocal imaging within dermal tissue
US6052224A (en) 1997-03-21 2000-04-18 Northern Edge Associates Microscope slide system and method of use
DE19729245C1 (de) 1997-07-09 1999-05-06 Evotec Biosystems Ag Spiegelobjektiv und dessen Verwendung
US6185030B1 (en) 1998-03-20 2001-02-06 James W. Overbeck Wide field of view and high speed scanning microscopy
US8024027B2 (en) 1998-09-03 2011-09-20 Hyperspectral Imaging, Inc. Infrared endoscopic balloon probes
US6392752B1 (en) 1999-06-14 2002-05-21 Kenneth Carlisle Johnson Phase-measuring microlens microscopy
DE60016761T2 (de) 1999-08-02 2005-12-15 Zetetic Institute, Tucson Interferometrische konfokale nahfeld-abtastmikroskopie
DE10026392A1 (de) 2000-05-27 2001-11-29 Leica Microsystems Verfahren und Anordnung zur Kodierung von Livebildern in der Mikroskopie
EP1311824A4 (de) * 2000-06-25 2010-12-08 Affymetrix Inc Optisch aktive substrate
EP2299307A3 (de) 2000-11-03 2011-05-04 Cytyc Corporation Zytologische Abbildungsmethode
JP3824135B2 (ja) 2001-01-10 2006-09-20 横河電機株式会社 バイオチップ読取り装置
US6416190B1 (en) 2001-04-27 2002-07-09 University Of Chicago Apparatus for using optical tweezers to manipulate materials
US6991939B2 (en) 2001-07-19 2006-01-31 Tufts University Optical array device and methods of use thereof for screening, analysis and manipulation of particles
EP1438385A1 (de) 2001-10-25 2004-07-21 Bar-Ilan University Interaktiver transparenter biochip-prozessor für einzeln adressierbare zellen
FR2834349B1 (fr) 2001-12-28 2004-04-09 Mauna Kea Technologies Appareillage d'imagerie confocale notamment pour endoscope
WO2003065774A1 (en) 2002-01-29 2003-08-07 Forskningscenter Risø Multi-beam optical tweezers
EP1499877B1 (de) 2002-04-22 2009-04-15 Hans Joachim Bruins Messanordnung für spektroskopische messungen
US6927888B2 (en) 2002-05-13 2005-08-09 Juan Manuel Bueno Garcia Method and apparatus for imaging using polarimetry and matrix based image reconstruction
DE10234755A1 (de) 2002-07-30 2004-02-26 Leica Microsystems Wetzlar Gmbh Trägervorrichtung für ein biologisches, mittels Laser-Mikrodissektion schneidbares Präparat
EP2287858B1 (de) 2002-07-31 2014-01-15 Premium Genetics (UK) Limited System und Verfahren zum Sortieren von Materialien mit holographischer Lasersteuerung
JP4562165B2 (ja) 2002-08-28 2010-10-13 株式会社東海ヒット 顕微鏡観察用培養器
JP2004101871A (ja) * 2002-09-10 2004-04-02 Olympus Corp 顕微鏡画像撮影装置
US7109473B2 (en) 2002-09-16 2006-09-19 University Of Chicago Transverse optical accelerator and generalized optical vortices
KR100721414B1 (ko) 2002-09-30 2007-05-23 도꾸리쯔교세이호징 가가꾸 기쥬쯔 신꼬 기꼬 공초점 현미경, 공초점 현미경을 사용한 형광 측정 방법 및편광 측정 방법
DE10252837B4 (de) * 2002-11-13 2005-03-24 Carl Zeiss Untersuchungssystem und Untersuchungsverfahren
JP2005007530A (ja) 2003-06-19 2005-01-13 Fuji Photo Film Co Ltd 光ピンセット装置
US7422377B2 (en) 2003-06-30 2008-09-09 Finisar Corporation Micro-module with micro-lens
US20050018199A1 (en) 2003-07-24 2005-01-27 Leblanc Philip R. Fiber array interferometer for inspecting glass sheets
GB2408587A (en) 2003-11-28 2005-06-01 Univ Hertfordshire Optical particle manipulation systems
US7193782B2 (en) 2003-12-30 2007-03-20 Massachusetts Institute Of Technology System and method for manipulating micro-particles using electromagnetic fields
CA2561575C (en) 2004-03-31 2013-05-21 Forskningscenter Riso Generation of a desired three-dimensional electromagnetic field
DE112005002510A5 (de) 2004-08-05 2007-07-12 Jpk Instruments Ag Vorrichtung zum Aufnehmen einer Messprobe
US7253947B2 (en) 2004-10-07 2007-08-07 New York University Portable automated confocal microscope
US7586684B2 (en) 2005-01-21 2009-09-08 New York University Solute characterization by optoelectronkinetic potentiometry in an inclined array of optical traps
WO2006113482A1 (en) 2005-04-14 2006-10-26 The Government Of The United States Of America, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health Ultrahigh-resolution fiber-optic confocal microscope and method of use
WO2007042989A1 (en) 2005-10-11 2007-04-19 Ecole Polytechnique Federale De Lausanne (Epfl) Miniaturized optical tweezer array with an array of reflective elements for reflecting the light back to a focal area
JP2009516568A (ja) 2005-11-23 2009-04-23 ユニヴァーシティ オブ ワシントン 中断される走査共振を使用する可変順次フレーミングを用いたビームの走査
US7628865B2 (en) 2006-04-28 2009-12-08 Asml Netherlands B.V. Methods to clean a surface, a device manufacturing method, a cleaning assembly, cleaning apparatus, and lithographic apparatus
US7646490B2 (en) 2006-07-25 2010-01-12 Zetetic Institute Apparatus and method for in situ and ex situ measurement of spatial impulse response of an optical system using phase shifting point-diffraction interferometry
US7968839B2 (en) 2006-07-26 2011-06-28 Ecole Polytechnique Federale De Lausanne (Epfl) Miniaturized optical tweezers based on high-NA micro-mirrors
WO2008127410A2 (en) 2006-11-07 2008-10-23 New York University Holographic microfabrication and characterization system for soft matter and biological systems
DE102007009551B3 (de) 2007-02-27 2008-08-21 Ludwig-Maximilian-Universität Vorrichtung für die konfokale Beleuchtung einer Probe
US8415612B2 (en) 2007-05-18 2013-04-09 The Regents Of The University Of Colorado Channel cell system
US8405021B2 (en) 2007-05-18 2013-03-26 The Regents Of The University Of Colorado Ultracold-matter systems
US8081305B2 (en) 2007-05-21 2011-12-20 Ahura Scientific Inc. Preparing samples for optical measurement
CN101909509B (zh) 2007-11-12 2013-03-27 康奈尔大学 多路径、多放大率、非共焦荧光发射内窥镜装置和方法
WO2010011953A1 (en) 2008-07-25 2010-01-28 Sloan Kettering Institute For Cancer Research Rapid confocal microscopy to support surgical procedures
WO2010055454A1 (en) 2008-11-14 2010-05-20 Koninklijke Philips Electronics N.V. Optical fiber scanning probe
WO2010084478A2 (en) 2009-01-24 2010-07-29 Ecole Polytechnique Federale De Lausanne (Epfl) High-resolution microscopy and photolithography devices using focusing micromirrors
DE102009020663A1 (de) 2009-05-11 2010-11-25 Carl Zeiss Ag Mikroskopie eines Objektes mit einer Abfolge von optischer Mikroskopie und Teilchenstrahlmikroskopie
WO2011091283A1 (en) 2010-01-22 2011-07-28 Board Of Regents, The University Of Texas System Systems, devices and methods for imaging and surgery
EP2520923A1 (de) 2011-05-06 2012-11-07 bioMérieux Bio-Bildgebungsverfahren und -system
KR101300733B1 (ko) 2012-01-12 2013-08-27 연세대학교 산학협력단 다중 병렬 공초점 시스템
US8371182B1 (en) 2012-06-11 2013-02-12 Jacob Israelachvili Mounting systems for a surface forces apparatus
US9563044B2 (en) 2012-07-17 2017-02-07 Ecole Polytechnique Federale De Lausanne Reflective optical objective
US20140193892A1 (en) 2012-07-25 2014-07-10 Theranos, Inc. Image analysis and measurement of biological samples
CA2881790A1 (en) 2012-08-13 2014-02-20 Memorial Sloan-Kettering Cancer Center Devices applicable to tissue(s) which facilitates confocal microscopy, optical microscopy, spectroscopy and/or imaging
JP6229278B2 (ja) 2013-03-06 2017-11-15 株式会社サタケ 穀粒透視器
EP2821796B1 (de) 2013-07-05 2024-09-04 Universität Basel Probenhalter für ein Rasterkraftmikroskop
US9695458B2 (en) 2013-08-27 2017-07-04 Parker-Hannifin Corporation Sample dish and compressed gas microbial test unit
US9733152B2 (en) 2013-12-17 2017-08-15 Bioptigen, Inc. Immersion lens assemblies for use in optical coherence tomography systems
EP3140691A4 (de) 2014-05-05 2018-01-03 Health Research, Inc. Klinisches intravitalmikroskop
US9678323B2 (en) 2014-06-10 2017-06-13 President And Fellows Of Harvard College High throughput multichannel fluorescence microscopy with microlens arrays
EP3278166A2 (de) 2015-03-31 2018-02-07 Samantree Medical SA Systeme und verfahren zur bildgebung im operationssaal von frischem, während der operation zur pathologischen beurteilung reseziertem gewebe
JP6688323B2 (ja) 2015-07-02 2020-04-28 ベンタナ メディカル システムズ， インコーポレイテッド 流体制御要素を組み込んだ対向部および自動検体処理システム
WO2019014767A1 (en) 2017-07-18 2019-01-24 Perimeter Medical Imaging, Inc. SAMPLE CONTAINER FOR STABILIZING AND ALIGNING EXCISED ORGANIC TISSUE SAMPLES FOR EX VIVO ANALYSIS
US11747603B2 (en) 2017-10-31 2023-09-05 Samantree Medical Sa Imaging systems with micro optical element arrays and methods of specimen imaging
US10928621B2 (en) 2017-10-31 2021-02-23 Samantree Medical Sa Sample dishes for use in microscopy and methods of their use
US10539776B2 (en) 2017-10-31 2020-01-21 Samantree Medical Sa Imaging systems with micro optical element arrays and methods of specimen imaging

Also Published As

Publication number Publication date
WO2019086550A2 (en) 2019-05-09
US10816788B2 (en) 2020-10-27
WO2019086550A3 (en) 2019-06-13
US20220035147A1 (en) 2022-02-03
US10539776B2 (en) 2020-01-21
US20200393665A1 (en) 2020-12-17
US11609416B2 (en) 2023-03-21
WO2019086550A8 (en) 2019-08-08
EP3704528A2 (de) 2020-09-09
US20190137752A1 (en) 2019-05-09
EP3704528B1 (de) 2025-12-10
US11181728B2 (en) 2021-11-23
US20200033581A1 (en) 2020-01-30

Similar Documents

Publication Publication Date Title
EP3704528C0 (de) Abbildungssysteme mit mikrooptischen elementarrays und verfahren zur probenabbildung
EP3884411A4 (de) Systeme und verfahren zur erkennung von malware und ransomware auf der basis von kryptowährung
EP3622333A4 (de) Suchspiegelsysteme und -verfahren
EP3755212A4 (de) Systeme und verfahren zur überwachung von personen
EP3803265A4 (de) Systeme und verfahren zur photonischen verarbeitung
EP3743330A4 (de) Drohnensysteme und -verfahren
EP3773137A4 (de) Systeme und verfahren zur gleichzeitigen bildgebung mit nahinfrarotlicht und sichtbarem licht
EP3737467A4 (de) Systeme und verfahren zur klinischen neuronavigation
EP3532888A4 (de) Optische systeme für femtoprojektorsysteme
EP3443694A4 (de) Glasfaserkommunikationssysteme und -verfahren
EP3692743A4 (de) Systeme und verfahren zur (wieder)auswahl von zellen und zellensperre
EP3466031A4 (de) Systeme und verfahren zur feststellung von anomalien
EP3408677A4 (de) Systeme und verfahren zur kalibrierung eines optischen distanzsensors
EP3335067A4 (de) Optisches system mit kurzer fokuslinse und bildgebungsvorrichtung damit
EP3367887A4 (de) Verfahren und vorrichtungen zur multispektralen, zeitaufgelösten optischen bildgebung zur gewebeklassifizierung
EP3445282A4 (de) Diametral einstellbare endoprothesen sowie entsprechende systeme und verfahren
EP3864578A4 (de) Makroinspektionssystem, -vorrichtung und -verfahren
EP3346905A4 (de) Kohärenzgesteuerte mehrphotonenmikroskopie mit adaptiver optik und ohne wellenfrontsensor sowie zugehörige systeme und verfahren
EP3807830A4 (de) Systeme und verfahren für vernetzung zwischen unternehmen auf der basis von verteilten konten
EP3407116A4 (de) Optisches element, anzeigevorrichtung damit und lichtempfangende vorrichtung
EP3572859A4 (de) Linsensystem mit fester brennweite und kamera
EP3895089A4 (de) Einparkverfahren und -systeme
EP3582642A4 (de) Optische artikel und damit interagierende systeme
EP3344972A4 (de) Optische systeme und verfahren zur charakterisierung von dielektrika mit hoher konstante
EP3668368A4 (de) Systeme und verfahren für brillouin-spektroskopie und bildgebung von geweben

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: UNKNOWN

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20200530

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: SAMANTREE MEDICAL SA

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20231024

REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Free format text: PREVIOUS MAIN CLASS: G02B0021000000

Ipc: H04N0023560000

Ref document number: 602018087826

Country of ref document: DE

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

RIC1 Information provided on ipc code assigned before grant

Ipc: H04N 23/56 20230101AFI20250616BHEP

Ipc: G02B 21/00 20060101ALI20250616BHEP

INTG Intention to grant announced

Effective date: 20250710

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: CH

Ref legal event code: F10

Free format text: ST27 STATUS EVENT CODE: U-0-0-F10-F00 (AS PROVIDED BY THE NATIONAL OFFICE)

Effective date: 20251210

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602018087826

Country of ref document: DE

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: W10

Free format text: ST27 STATUS EVENT CODE: U-0-0-W10-W00 (AS PROVIDED BY THE NATIONAL OFFICE)

Effective date: 20260114

REG Reference to a national code

Ref country code: CH

Ref legal event code: R17

Free format text: ST27 STATUS EVENT CODE: U-0-0-R10-R17 (AS PROVIDED BY THE NATIONAL OFFICE)

Effective date: 20260206

RAP4 Party data changed (patent owner data changed or rights of a patent transferred)

Owner name: SAMANTREE MEDICAL (SWITZERLAND) SA

U01 Request for unitary effect filed

Effective date: 20260108