EP3589960A1 - Vorrichtung und verfahren zur bestimmung wenigstens eines physikalischen parameters pharmazeutischer produkte - Google Patents
Vorrichtung und verfahren zur bestimmung wenigstens eines physikalischen parameters pharmazeutischer produkteInfo
- Publication number
- EP3589960A1 EP3589960A1 EP18710147.2A EP18710147A EP3589960A1 EP 3589960 A1 EP3589960 A1 EP 3589960A1 EP 18710147 A EP18710147 A EP 18710147A EP 3589960 A1 EP3589960 A1 EP 3589960A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- product
- gripper jaws
- transport system
- products
- pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/13—Moving of cuvettes or solid samples to or from the investigating station
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0339—Holders for solids, powders
Definitions
- the invention relates to a device for determining at least one physical parameter of pharmaceutical products, such as tablets, pills, oblongs or the like, according to the preamble of claim 1, and a method for determining at least one physical parameter of pharmaceutical products, such as tablets, pills, oblongs or the like, according to the preamble of claim 16.
- a device for determining at least one physical parameter of pharmaceutical products such as tablets, pills, oblongs or the like
- a method for determining at least one physical parameter of pharmaceutical products such as tablets, pills, oblongs or the like, according to the preamble of claim 16.
- the device consists of a feeder, which separates the collected specimens, and a transport star with peripherally arranged receiving chambers for each test specimen, in which the specimens are supplied.
- Test specimens deposited in the receiving chambers are progressively fed to one or more test stations by means of the transport star and, if they are nondestructive tests, subsequently ejected, for example, into a linear conveyor and closed Archived for archival purposes.
- the ejection of the destroyed specimens usually takes place directly in the respective test station, for example, by an opening in a receiving chambers limiting the bottom, on which the transport star rotates.
- the test stations are, for example, a hardness tester, a balance and a device for determining the dimensions, such as length and / or width and / or thickness of the test specimens.
- NIR test Near Infra Red
- NIR test uses electromagnetic waves of the near infrared range for the examination of the test specimens, has proven particularly expedient.
- a system which consists of an automatic tablet tester (for example, weight, thickness, diameter and hardness) and an NIR test system.
- the tablet is discharged after measurement of weight and thickness and vibrated into a tablet holder.
- This tablet holder is brought to the NIR system, the measurement is started and then the tablet is placed in a tube or magazine.
- the tablets After the pressing process, the tablets are partly still warm and therefore slightly larger than in the cooled state.
- the detection is the tablet really in the holder and 100% oriented
- the detection is complex and not reliable.
- the measurement z. B. with NIR tablets are individually for example for subsequent control measurements in a tablet Magazine filed.
- the tablet is blown out of the holder with a stream of air and deposited via an orientation channel into the corresponding tube.
- the required parts are made tablet-specific.
- Another disadvantage is the process reliability (monitoring with sensors very expensive)
- Patent EP2160599 describes the positioning and orientation of an object over a bearing surface of a slider.
- the disadvantage here is that the underside of the slider, e.g. for a concave tablet, it must be adapted to the specific tablet. The prevention of unwanted stray light is not 100% resolved.
- the slider used here can be a disadvantage if you want to bring the tablet to exactly defined positions or wants to record there or wants to supply directly after the measurement, for example, in a tube.
- Object of the present invention is therefore to provide a device and to provide a method which does not have the aforementioned disadvantages and in particular with little effort an exact positioning and optionally also alignment of an object, for. B. allow a to be tested by means of a test apparatus pharmaceutical on a base or support surface.
- the object is solved by the features of independent claims 1 and 16. Advantageous developments are set forth in the figures and in the dependent claims.
- Starting point is a device for determining at least one physical and / or chemical parameter of pharmaceutical products, with at least one test station and with at least one automatic Tran sportsystem for the products to and / or between and / or within and / or from the or each test station.
- These products may be, for example, tablets, pills, oblongs or the like.
- the transport system has a controllable holding device for non-positive and / or positive reception of the pharmaceutical products, wherein the travel paths and the spatial orientation of the holding device are freely programmable. This ensures a well-defined connection of the product with the transport device, through which the exact position and spatial position of the product is known and can be adjusted at any time in the test procedure subsequently run by the product. Handling is therefore particularly flexible possible and incorrect measurements due to positioning errors can be minimized.
- the holding device is arranged on a preferably freely programmable robot arm. This proven technique makes it easy to start any desired position with the pharmaceutical product and its orientation in any desired spatial position.
- At least one of the test stations is a device for a transmission or reflection measurement.
- this device comprises a Aufoder or contact surface for the pharmaceutical product.
- An advantageous embodiment of the device according to the invention is characterized in that the device for radiographic or reflectance measurement has an opaque for the wavelengths used and at least during the transmission measurement the product partially positively receiving support in which a fully coverable by the product passage opening is worked. This makes it possible to reduce incorrect measurements due to extraneous and stray light.
- the holding device of the robot arm preferably has at least two gripper jaws which can be adjusted relative to one another, the device according to the invention can be adjusted quickly and easily to different pharmaceutical products, the control for receiving the product is very simple and the product can be picked up, transported, positioned and stored very flexibly become.
- An advantageous embodiment provides that the gripping surface facing the respectively opposite gripper jaw is shaped such that an at least two-point support is formed for the product between the gripper jaws. This is a simple way to accomplish a good frictional uptake of the product by the transport system.
- a particularly good holding action for the safe transport of the pharmaceutical products can be ensured by an alternative embodiment in which the gripping surfaces of the gripper jaws are shaped complementary to at least a part of the peripheral contour of the products.
- An advantageous because constructively simple and executable in a small size embodiment of the invention is characterized in that the gripper jaws face each other pincers and each other to be closed and away from each other.
- an embodiment is possible in which the gripper jaws are arranged along a closed contour and a central space for receiving the pharmaceutical product exhibit. This variant offers the advantage of the best possible absorption and retention effect by the transport system on the pharmaceutical product.
- controllable holding device and / or any gripper jaws have sensors for determining the path of any gripper jaws and / or the force exerted on the pharmaceutical products.
- a further advantageous embodiment of the inventive device provides that at the transfer position of the pharmaceutical product to the transport system, a turntable is arranged, on which the product comes to rest immediately before the positive and / or positive recording by the transport system.
- a turntable is arranged, on which the product comes to rest immediately before the positive and / or positive recording by the transport system.
- the holding effect can be improved while simultaneously protecting the products against damage during handling if, according to a further optional feature of the invention, the gripping surface of at least one of the gripper jaws is covered with an elastic layer.
- the layer lining the gripper jaws may consist of a material which is impermeable to the wavelengths used in the radiographic measurement, in order to largely prevent erroneous measurements by stray light and extraneous light as well. This solution is also for Radiation or reflection measurements with tablet pads without elastic cover sends particularly advantageous.
- An advantageous embodiment of the device according to the invention is characterized in that the gripper jaws have protrusions protruding inwards over a clamped product, and that the height of the gripper jaws, which projects beyond the bottom of the protrusion, is less than the thickness of the products.
- the holding effect and the prevention of stray light in transmitted light or radiographic measurements can be further improved.
- the Tran sportsystem is designed to exercise a force acting on the product in the direction of the support pressure.
- the solution to the problem set out above is also possible for a method for determining at least one physical parameter of pharmaceutical products, such as, for example, tablets, pills, oblongs or the like.
- at least one chemical or physical property is tested and the product is transported and handled between and / or during and / or after at least one test procedure by an automatic transport system.
- the transport path of the product and its spatial orientation are at least partially preprogrammed independently of the spatial apparatus arrangement and are preferably traversed by means of a robot arm.
- at least one property of the product is preferably determined by means of a transmission or reflection measurement.
- the product is fixed in a stationary manner with respect to the device for radiographic measurement, preferably in the direction of a support with a pressure force.
- the product is left moveable during the transmission or reflection measurement.
- several measurements can be carried out, preferably at different points of the product. For example, in the case of oblong products such as oblongs, irradiation or a reflection measurement in the middle and in the two end sections could take place, for example, to determine an average value.
- the product during at least part of the transport path with the transport system, preferably a holding device of the transport system, positively and / or positively coupled.
- a further variant of the method according to the invention is characterized in that, at least after completion of all tests, the product is deposited in a file by means of the transport system or transferred to further test systems, trays or handling systems.
- FIG. 1 shows a section of a first embodiment of a device according to the invention
- FIG. 2 is a perspective view of a holding device in accordance with the invention
- 3 is a longitudinal section through a holding device according to FIG. 2, placed on a tablet nest of a transmission measurement
- FIG. 3 is a perspective view of a holding device in accordance with the invention
- Fig. 4 is a perspective view of an alternative embodiment of a
- FIG. 5 shows a further detail of an embodiment of a device according to the invention in a perspective view
- Fig. 6 is a schematic representation of a gripper jaw assembly with a closed contour
- Fig. 7 also a schematic representation of another
- Fig. 1 shows a section of a device for determining at least one physical parameter of pharmaceutical products. These may be tablets, pills, oblongs or the like.
- the device has at least one inspection station 1 and at least one automatic transport system for the products to and / or between and / or within and / or from the or each inspection station 1.
- the determination of at least one physical parameter of these pharmaceutical products takes place.
- At least one chemical or physical property is tested, wherein the product is transported and handled between and / or during and / or after the at least one inspection operation by an automatic transport system.
- the Tran sportsystem comprises at least one robot arm 2 with at least one controllable holding device 3 for the pharmaceutical products.
- the travel distances of the robot arm 2 itself and also those of the holding device 3 and the spatial orientation of the holding device 3 on this robot arm 2 are freely programmable.
- the pharmaceutical product can be spatially moved to any position within the range of the robot arm 2, and in accordance with the movable attachment of the holding device 3 at the free end of the robot arm 2 also in each any spatial orientation.
- the robot arm 2 can be controlled in such a way that the transport path of the product and its spatial orientation are at least partially preprogrammed independently of the spatial apparatus arrangement and traversed by means of the robot arm 2.
- At least one of the test stations 1 is a device for a transmission or reflection measurement.
- a pharmaceutical product measurements with NIR (Near Infra Red)
- RAMAN or similar detectors are common.
- this product for example the tablet T shown in FIGS. 2 to 4, is transported by means of the robot arm 2 to a tablet nest 4 (see FIGS. 2 and 3) ,
- This preferably consists of a solid, usually metallic lower part 5, possibly part of a support structure 5a, and a receptacle attached thereto made of elastically yielding material, in particular a plastic disc 6.
- the radiation used for the measurement can be supplied, for example, by means of a radiation conductor 7.
- the lower part 5 and the plastic disc 6, however, are impermeable to radiation.
- the robot arm 2 may be mounted on the support structure 5a.
- the tablet T is advantageously clamped by means of two relatively adjustable gripper jaws 8 of the holding device 3 at the free end of the robot arm 2 preferably positive fit and thus safe held.
- the gripper jaws 8 can also be designed resiliently in order to compensate for the size tolerances of the products or to react to the change in size in the course of a temperature change of the products (change in the production of tablets from warm to cold).
- the pharmaceutical product can not only be deposited by the holding device 3 of the robot arm 2, but pressed with an adjustable force on the plastic disc 6, so that a positive connection between the bottom of the tablet T and the top of the plastic disc 6 results, which prevents any gap for unwanted scattered light or stray radiation to the radiation detector.
- this is the Tran sportsystem, especially the robot arm 2, designed to exercise a force acting on the product in the direction of the support pressure.
- the product T is fixed in relation to the device 1 in a stationary manner. This fixation is preferably achieved or supported by the fact that the product is acted upon in the direction of the support with a pressing force.
- the product during at least part of the transport path with the Tran sportsystem preferably a holding device 3 of the designed as a robot arm 2 transport system, non-positively and / or positively coupled with the Tran sportsystem.
- the fixation of the pharmaceutical products for radiographic or reflection measurement is not mandatory. Rather, it may be advantageous for certain measurements if the product is left mobile during the transmission or reflection measurement.
- a tablet T clamped, for example, in gripper jaws 8 is released for a short time by opening the gripper jaws 8 after depositing the product and only for the transmission or reflection measurement.
- the product T is preferably coupled again in the same way as explained above by gripping with the holding device 3 of the transport system with this system.
- a plurality of measurements can be carried out, preferably at different locations of the product T.
- measurements can be carried out at different points of the product and an average value for the measured value can be determined over the entire product.
- the gripping surface facing the respectively opposite gripper jaw 8 may be shaped such that an at least two-point support is formed for the product between the gripper jaws 8.
- the gripping surfaces of the gripper jaws 8 could also be shaped to be complementary to at least part of the peripheral contour of the products.
- an embodiment may be advantageous in which the gripping surface of at least one of the gripper jaws 8 is covered with an elastic layer 9, preferably made of plastic material. This layer 9 can also represent an additional seal to avoid unwanted scattered radiation in the transmission measurement.
- the holding device 3 is designed such that at least one of the gripper jaws 8 has at least one recess which is shaped so that there is a gap between the contact surfaces for receiving the pharmaceutical product, which can be enlarged to open the arrangement of the gripper jaws 8 and to Close is reducible.
- the gripper jaws 8 are - optionally adapted or adaptable to the product - shaped so that the product to be tested with open gripper jaws 8 via an access opening into the space and introduced in this closed gripper jaws 8 form fit and / or non-positively in the space between the Gripper jaws 8 is held.
- the procedure is preferably as follows:
- the gripper jaws 8 of the holding device 3 are opened, then the product is applied to a support surface, the holding device 3 is preferably moved so that the object comes to rest in the intermediate space.
- the gripper jaws 8 are closed, and thereby the product is positioned on the support surface at a location determined by the shape of the contact surfaces and, if necessary, aligned.
- all steps are fully automatic, z. B. computer controlled performed.
- the height of the gripper jaws 8 projecting beyond the bottom of the projection is preferably smaller than the thickness of the products.
- gripper jaws 8 which are opposite one another and can be closed and moved away from one another. These grippers are preferably arranged parallel to one another and movable essentially transversely to their longitudinal extension, preferably held by a base unit of the holding device 3 and by means of this holding device 3 connected to, for example, the robot arm 2. Particularly advantageously, the gripper jaws 8 are interchangeably mounted in the holding device 3 in order to adapt them to different types of pharmaceutical products T or to repair or replace them in the case of malfunctions.
- FIGS. 6 and 7 Such arrangements of gripper jaws 8 are shown in FIGS. 6 and 7, which can preferably completely surround and clamp the pharmaceutical product T along its circumference. They have a central open space for receiving the pharmaceutical product T and ensure a particularly good absorption and holding action on the pharmaceutical product T.
- the product T facing the contours of the gripper jaws 8 are formed exactly complementary to the outer circumferential contour of the product T.
- controllable holding device and / or at least one of the gripper jaws 8 may have a sensor for determining the path of any gripper jaws 8 and / or exerted on the pharmaceutical products T force.
- a displacement sensor By way of a displacement sensor, the working travel of the respective receiving structure, for example at least one gripper jaw 8, which is passed through during the reception of the product T, can be determined.
- This current path is compared in the control of the holding device 3 or the entire transport system with a reference value, which was determined in advance for a correct gripping operation with correct orientation of the pharmaceutical product T.
- a shortfall of the reference value point to a faulty orientation of the product T, however, an overrun on an unintentional destruction of the product during the gripping process or even that no product for transfer to the Tran sportsystem 2, 3 is present.
- the presence and / or the correct orientation of the product can be deduced.
- a force greater than the reference value suggests either a faulty gripper function with increased friction or jaw jaw clamping 8, or indicates an incorrect orientation of the product T.
- force readings below the reference value can be caused by a non-existent product or a wrong product (with less strength than expected). Both procedures individually or in combination can of course subsequently avoid incorrect measurements due to incorrect positioning of the product or by a wrong product.
- a further embodiment of the device according to the invention with a turntable at the transfer position of the pharmaceutical product to the transport system can be used.
- a turntable product T can be rotated immediately before the positive and / or positive recording by the transport system upon detection of a wrong orientation in the correct position for the takeover by the transport system.
- test stations of the inventive device can be approached in any order. For example, after radiographic or reflectance measurements, it is possible to return the pharmaceutical product to a test station 1 or a complete tablet tester, e.g. to measure hardness or other physical parameters.
- the tablets T or other products after irradiation or reflection measurement could also be fed directly into a tube 10 or similar magazine, with freely programmed Absetzpositionen, as in Figure 5
- the product After approaching these positions by the robot arm, preferably with the center of the product T within the edge of the tube 10, after opening the gripper jaws 8 of the holding device 3, the product automatically falls into the tube 10.
- the product can also be passed on to other testing systems or handling systems at least after completion of all desired tests by means of the transport system. LIST OF REFERENCE NUMBERS
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Robotics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Specific Conveyance Elements (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17158518.5A EP3367103A1 (de) | 2017-02-28 | 2017-02-28 | Vorrichtung und verfahren zur bestimmung wenigstens eines physikalischen parameters pharmazeutischer produkte |
PCT/IB2018/051088 WO2018158661A1 (de) | 2017-02-28 | 2018-02-22 | Vorrichtung und verfahren zur bestimmung wenigstens eines physikalischen parameters pharmazeutischer produkte |
Publications (1)
Publication Number | Publication Date |
---|---|
EP3589960A1 true EP3589960A1 (de) | 2020-01-08 |
Family
ID=58266366
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP17158518.5A Withdrawn EP3367103A1 (de) | 2017-02-28 | 2017-02-28 | Vorrichtung und verfahren zur bestimmung wenigstens eines physikalischen parameters pharmazeutischer produkte |
EP18710147.2A Withdrawn EP3589960A1 (de) | 2017-02-28 | 2018-02-22 | Vorrichtung und verfahren zur bestimmung wenigstens eines physikalischen parameters pharmazeutischer produkte |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP17158518.5A Withdrawn EP3367103A1 (de) | 2017-02-28 | 2017-02-28 | Vorrichtung und verfahren zur bestimmung wenigstens eines physikalischen parameters pharmazeutischer produkte |
Country Status (3)
Country | Link |
---|---|
US (1) | US20200064255A1 (de) |
EP (2) | EP3367103A1 (de) |
WO (1) | WO2018158661A1 (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201910801D0 (en) * | 2019-07-29 | 2019-09-11 | Agilent Tech Lda Uk Limited | Raman analysis of pharmaceutical dosage forms |
US11427407B2 (en) * | 2020-01-24 | 2022-08-30 | Becton Dickinson Rowa Germany Gmbh | Apparatus and method for identifying, measuring and positioning piece goods |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2770243B2 (ja) * | 1989-09-21 | 1998-06-25 | ライオンエンジニアリング株式会社 | 錠剤成分量検査方法およびその装置 |
JP2874328B2 (ja) * | 1990-10-29 | 1999-03-24 | 味の素株式会社 | 自動前処理装置 |
US5679954A (en) * | 1994-11-14 | 1997-10-21 | Soloman; Sabrie | Non-destructive identification of tablet and tablet dissolution by means of infared spectroscopy |
DE10024598C2 (de) | 2000-05-21 | 2003-03-13 | Norbert Kraemer | Vorrichtung zur automatischen Qualitätskontrolle von Prüflingen |
JP2002370187A (ja) * | 2001-06-12 | 2002-12-24 | Sony Corp | 電池ハンドリング装置 |
US7051606B2 (en) | 2004-01-30 | 2006-05-30 | Andrx Labs Llc | Dosage form holder device and methods for immersion testing |
GB2446166B (en) * | 2007-01-29 | 2010-05-12 | Teraview Ltd | A pharmaceutical analysis method and apparatus |
WO2008121692A1 (en) | 2007-03-30 | 2008-10-09 | University Of South Carolina | Tablet analysis and measurement system |
DE102007054909B4 (de) | 2007-06-20 | 2010-12-09 | Thilo Kraemer | Vorrichtung und Verfahren zur Ausrichtung eines tablettenförmigen Prüflings |
DE102008035830B4 (de) | 2008-07-31 | 2021-12-16 | Pharma Test Apparatebau AG | Vorrichtung zur Durchführung des Härtetests von Prüflingen |
EP2728341A4 (de) | 2011-06-28 | 2015-04-22 | Otsuka Pharma Co Ltd | Arzneimittelprüfvorrichtung und arzneimittelprüfverfahren |
US8935001B2 (en) * | 2012-03-29 | 2015-01-13 | bioMeriéux, Inc. | System and method for establishing and/or maintaining proper alignment of a robotic transfer mechanism |
WO2014089406A1 (en) | 2012-12-07 | 2014-06-12 | The United States Of America, As Represented By The Secretary,Department Of Health & Human Services | Device and method for detection of counterfeit pharmaceuticals and/or drug packaging |
CN105208995B (zh) | 2013-05-22 | 2020-01-14 | 普和希控股公司 | 药片检查装置以及药片检查方法 |
GB2524130B (en) | 2014-09-24 | 2016-02-24 | Lpw Technology Ltd | Analysing Apparatus |
-
2017
- 2017-02-28 EP EP17158518.5A patent/EP3367103A1/de not_active Withdrawn
-
2018
- 2018-02-22 WO PCT/IB2018/051088 patent/WO2018158661A1/de unknown
- 2018-02-22 US US16/489,059 patent/US20200064255A1/en not_active Abandoned
- 2018-02-22 EP EP18710147.2A patent/EP3589960A1/de not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
US20200064255A1 (en) | 2020-02-27 |
WO2018158661A1 (de) | 2018-09-07 |
EP3367103A1 (de) | 2018-08-29 |
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