EP3555088B1 - Bisaryle amides en tant que régulateurs de nrf2 - Google Patents

Bisaryle amides en tant que régulateurs de nrf2 Download PDF

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EP3555088B1
EP3555088B1 EP17818304.2A EP17818304A EP3555088B1 EP 3555088 B1 EP3555088 B1 EP 3555088B1 EP 17818304 A EP17818304 A EP 17818304A EP 3555088 B1 EP3555088 B1 EP 3555088B1
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Prior art keywords
methyl
ethyl
benzo
triazol
dioxido
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EP3555088A1 (fr
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James Francis Callahan
Vincent J. Colandrea
Anthony William James Cooper
Nicole Cathleen Goodwin
Chelsea Ariane HUFF
Joel KARPIAK
Jeffrey K. Kerns
Hong Nie
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GlaxoSmithKline Intellectual Property Development Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D515/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Definitions

  • the present invention relates to bisaryl amide analogs, pharmaceutical compositions containing them and their use as NRF2 activators.
  • NRF2 (NF-E2 related factor 2) is a member of the cap-n-collar family of transcription factors containing a characteristic basic-leucine zipper motif. Under basal conditions, NRF2 levels are tightly controlled by the cytosolic actin-bound repressor, KEAP1 (Kelch-like ECH associating protein 1), which binds to NRF2 and targets it for ubiquitylation and proteasomal degradation via the Cul3-based E3-ubiquitin ligase complex. Under conditions of oxidative stress, DJ1 (PARK7) is activated and stabilizes NRF2 protein by preventing NRF2 from interacting with KEAP1.
  • modification of reactive cysteines on KEAP1 can cause a conformational change in KEAP1 that alters NRF2 binding and promotes NRF2 stabilization.
  • the levels of NRF2 in the cell are usually kept low in normal conditions but the system is designed to respond quickly to environmental stress by increasing NRF2 levels and thus downstream NRF2 activity.
  • NRF2 activators may treat COPD ( Boutten, A., et al. 2011. Trends Mol. Med. 17:363-371 ) and other respiratory diseases, including asthma, Acute Lung Injury (ALI) ( Cho, H.Y., and Kleeberger, S.R., 2015, Arch Toxicol. 89:1931-1957 ; Zhao, H.
  • NRF2 activator The therapeutic potential of an NRF2 activator is exemplified in pulmonary macrophages from COPD patients where NRF2 pathway appears maladaptive. These cells have impaired bacterial phagocytosis compared with similar cells from control patients, and this effect is reversed by the addition of NRF2 activators in vitro. Therefore, in addition to the effects mentioned above, restoration of appropriate NRF2 activity could also rescue COPD exacerbations by reducing lung infection.
  • NRF2 activator Sulforaphane
  • MARCO Macrophage Receptor with Collagenous structure
  • the therapeutic potential of targeting NRF2 in the lung is not limited to COPD. Rather, targeting the NRF2 pathway could provide treatments for other human lung and respiratory diseases that exhibit oxidative stress components such as chronic asthma and acute asthma, lung disease secondary to environmental exposures including but not limited to ozone, diesel exhaust and occupational exposures, fibrosis, acute lung infection (e.g., viral ( Arthur, T.L. et al. 2014. PLoS ONE 9(6): e98671 ), bacterial or fungal), chronic lung infection, ⁇ 1 antitrypsin disease, ALI, ARDS and cystic fibrosis ( CF, Chen, J. et al. 2008. PLoS One. 2008;3(10):e3367 ).
  • oxidative stress components such as chronic asthma and acute asthma, lung disease secondary to environmental exposures including but not limited to ozone, diesel exhaust and occupational exposures, fibrosis, acute lung infection (e.g., viral ( Arthur, T.L. et al. 2014. PLoS
  • a therapy that targets the NRF2 pathway also has many potential uses outside the lung and respiratory system. Many of the diseases for which an NRF2 activator may be useful are autoimmune diseases (psoriasis, IBD, MS), suggesting that an NRF2 activator may be useful in autoimmune diseases in general.
  • autoimmune diseases psoriasis, IBD, MS
  • NRF2 gene and protein expression is increased during the early stage of cardiac adaptive hypertrophy, but decreased in the later stage of maladaptive cardiac remodeling associated with systolic dysfunction [ Arterioscler Thromb Vasc Biol (2009) 29(11); 1843- 5 1850 ; PLOS ONE (2012) 7(9); e44899 ].
  • NRF2 activation has been shown to suppress myocardial oxidative stress as well as cardiac apoptosis, fibrosis, hypertrophy, and dysfunction in mouse models of pressure overload [ Arterioscler Thromb Vasc Biol (2009) 29(11 ); J of Mol & Cell Cardio (2014) 72; 305-315; and 1843-1850 ; PLOS ONE (2012) 7(9); e44899 ].
  • NRF2 activation has also been shown to protect against cardiac I/R injury in mice 10 [ Circ Res (2009) 105(4); 365-374 ; J of Mol & Cell Cardio (2010) 49(4); 576-586 ] and reduce myocardial oxidative damage following cardiac I/R injury in rat.
  • a drug targeting NRF2 by other mechanisms may be useful in a variety of cardiovascular diseases including but not limited to atherosclerosis, hypertension, and heart failure ( Oxidative Medicine and Cellular Longevity Volume 2013 (2013), Article ID 104308, 10 pages ), acute coronary 15 syndrome, myocardial infarction, myocardial repair, cardiac remodeling, cardiac arrhythmias, heart failure with preserved ejection fraction, heart failure with reduced ejection fraction and diabetic cardiomyopathy.
  • cardiovascular diseases including but not limited to atherosclerosis, hypertension, and heart failure ( Oxidative Medicine and Cellular Longevity Volume 2013 (2013), Article ID 104308, 10 pages ), acute coronary 15 syndrome, myocardial infarction, myocardial repair, cardiac remodeling, cardiac arrhythmias, heart failure with preserved ejection fraction, heart failure with reduced ejection fraction and diabetic cardiomyopathy.
  • a drug activating the NRF2 pathway could also be useful for treatment of several neurodegenerative diseases including Parkinson's disease (PD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS) ( Brain Res. 2012 Mar 29; 1446:109-18. 2011.12.064 . Epub 2012 Jan 12.) and multiple sclerosis (MS).
  • PD Parkinson's disease
  • AD Alzheimer's disease
  • ALS amyotrophic lateral sclerosis
  • MS multiple sclerosis
  • tBHQ tert-butylhydroquinone
  • NRF2 may also help treat cases of Friedreich's Ataxia, where increased sensitivity to oxidative stress and impaired NRF2 activation has been reported ( Paupe V., et al, 2009. PLoS One; 4(1):e4253 .
  • Omaveloxolone (RTA-408) is also in clinical trials for Friedreich's Ataxia.
  • Age-related macular degeneration is a common cause of vision loss in people over the age of 50. Cigarette smoking is a major risk factor for the development of non-neovascular (dry) AMD and perhaps also neovascular (wet) AMD. Findings in vitro and in preclinical species support the notion that the NRF2 pathway is involved in the anti-oxidant response of retinal epithelial cells and modulation of inflammation in pre-clinical models of eye injury ( Schimel, et al. 2011. Am. J. Pathol. 178:2032-2043 ). Fuchs Endothelial Corneal Dystrophy (FECD) is a progressive, blinding disease characterized by corneal endothelial cells apoptosis.
  • FECD Fuchs Endothelial Corneal Dystrophy
  • an NRF2 activator may be useful in uveitis or other inflammatory eye condtions.
  • Non-alcoholic steatohepatitis is a disease of fat deposition, inflammation, and damage in the liver that occurs in patients who drink little or no alcohol.
  • NASH Non-alcoholic steatohepatitis
  • KO mice lacking NRF2 when challenged with a methionine- and choline-deficient diet
  • a methionine- and choline-deficient diet Chowdhry S., et al. 2010. Free Rad. Biol. & Med. 48:357-371 .
  • Administration of the NRF2 activators oltipraz and NK-252 in rats on a choline-deficient L-amino acid-defined diet significantly attenuated progression of histologic abnormalities, especially hepatic fibrosis ( Shimozono R. et al. 2012.
  • liver diseases that may be amenable to NRF2 modulation are toxin-induced liver disease (e.g., acetaminophen-induced hepatic disease), viral hepatitis, and cirrhosis ( Oxidative Medicine and Cellular Longevity Volume 2013 (2013), Article ID 763257, 9 page ).
  • toxin-induced liver disease e.g., acetaminophen-induced hepatic disease
  • viral hepatitis e.g., cirrhosis
  • NRF2 activator may be beneficial in preeclampsia, a disease that occurs in 2-5% of pregnancies and involves hypertension and proteinuria ( Annals of Anatomy - Anatomischer appror Volume 196, Issue 5, September 2014, Pages 268-277 ).
  • WO 2016/203400 and WO 2016/202253 each disclose certain aryl analogs, pharmaceutical compositions containing the same and their use as NRF2 regulators.
  • this invention provides for bisaryl amide analogs, pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing them.
  • the compounds of this invention include the compounds of claim 1; or a pharmaceutically acceptable salt thereof.
  • the invention provides a pharmaceutical composition comprising a compound of the invention according to claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
  • this invention is directed to a pharmaceutical composition for the treatment of an NRF2 regulated disease or disorder, wherein the composition comprises a compound according to claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
  • Also described herein is a method of treating respiratory and non-respiratory disorders, including COPD, asthma, ALI, ARDS, fibrosis, chronic asthma, acute asthma, lung disease secondary to environmental exposures, acute lung infection, chronic lung infection, ⁇ 1 antitrypsin disease, cystic fibrosis, autoimmune diseases, diabetic nephropathy, chronic kidney disease, sepsis-induced acute kidney injury, acute kidney injury (AKI), kidney disease or malfunction seen during kidney transplantation, Pulmonary Arterial Hypertension, atherosclerosis, hypertension, heart failure, acute coronary syndrome, myocardial infarction, myocardial repair, cardiac remodeling, cardiac arrhythmias, heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, diabetic cardiomyopathy, Parkinson's disease (PD), Alzheimer's disease (AD), Friedreich's Ataxia (FA), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), inflammatory bowel disease, colon cancer, neovascular (dry)
  • a compound of Formula (I) for the treatment of respiratory and non-respiratory disorders, including COPD, asthma, ALI, ARDS, fibrosis, chronic asthma and acute asthma, lung disease secondary to environmental exposures, acute lung infection, chronic lung infection, ⁇ 1 antitrypsin disease, cystic fibrosis, autoimmune diseases, diabetic nephropathy, chronic kidney disease, sepsis-induced acute kidney injury, acute kidney injury (AKI), kidney disease or malfunction seen during kidney transplantation, Pulmonary Arterial Hypertension, atherosclerosis, hypertension, heart failure, acute coronary syndrome, myocardial infarction, myocardial repair, cardiac remodeling, cardiac arrhythmias, heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, diabetic cardiomyopathy, Parkinson's disease (PD), Alzheimer's disease (AD), Friedreich's Ataxia (FA), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), inflammatory bowel disease, colon cancer
  • a compound of Formula (I) or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for the treatment of respiratory and non-respiratory disorders, including COPD, asthma, ALI, ARDS, fibrosis, chronic asthma and acute asthma, lung disease secondary to environmental exposures, acute lung infection, chronic lung infection, ⁇ 1 antitrypsin disease, cystic fibrosis, autoimmune diseases, diabetic nephropathy, chronic kidney disease, sepsis-induced acute kidney injury, acute kidney injury (AKI), kidney disease or malfunction seen during kidney transplantation, Pulmonary Arterial Hypertension, atherosclerosis, hypertension, heart failure, acute coronary syndrome, myocardial infarction, myocardial repair, cardiac remodeling, cardiac arrhythmias, heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, diabetic cardiomyopathy, Parkinson's disease (PD), Alzheimer's disease (AD), Friedreich's Ataxia (FA), amyotrophic lateral sclerosis (ALS), multiple
  • Also described herein is a compound of claim 1or a pharmaceutically acceptable salt thereof, for use in medical therapy.
  • this invention relates to a compound of claim 1or a pharmaceutically acceptable salt thereof, for use in the treatment of respiratory and non-respiratory disorders, including COPD, asthma, ALI, ARDS, fibrosis, chronic asthma and acute asthma, lung disease secondary to environmental exposures, acute lung infection, chronic lung infection, ⁇ 1 antitrypsin disease, cystic fibrosis, autoimmune diseases, diabetic nephropathy, chronic kidney disease, sepsis-induced acute kidney injury, acute kidney injury (AKI), kidney disease or malfunction seen during kidney transplantation, Pulmonary Arterial Hypertension, atherosclerosis, hypertension, heart failure, acute coronary syndrome, myocardial infarction, myocardial repair, cardiac remodeling, cardiac arrhythmias, heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, diabetic cardiomyopathy, Parkinson's disease (PD), Alzheimer's disease (AD), Friedreich's Ataxia (FA), amyotrophic lateral sclerosis (ALS), multiple s
  • this invention relates to a compound of claim 1 or a pharmaceutically acceptable salt thereof, for use in the treatment COPD.
  • this invention relates to a compound of claim 1 or a pharmaceutically acceptable salt thereof, for use in the treatment of heart failure.
  • a compound of Formula (I), or a pharmaceutically acceptable salt thereof as an active therapeutic substance. More specifically, described herein is the use of the compounds described herein for the treatment of a respiratory and non-respiratory disorder, specifically, a disease or disorder recited herein. Accordingly, described herein is the use of a compound of Formula (I), or a pharmaceutically acceptable salt thereof, as an active therapeutic substance in the treatment of a human in need thereof with a respiratory and non-respiratory disorder, specifically, a disease or disorder recited herein. Specifically, described herein is the use of a compound of Formula (I), or a pharmaceutically acceptable salt thereof, as an active therapeutic substance in the treatment of COPD. Specifically, described herein is the use of a compound of Formula (I), or a pharmaceutically acceptable salt thereof, as an active therapeutic substance in the treatment of heart failure.
  • Alkyl refers to a monovalent saturated hydrocarbon chain having the specified number of carbon member atoms.
  • C 1-4 alkyl refers to an alkyl group having from 1 to 4 carbon member atoms.
  • Alkyl groups may be straight or branched. Representative branched alkyl groups have one, two, or three branches.
  • Alkyl includes methyl, ethyl, propyl, (n-propyl and isopropyl), and butyl (n-butyl, isobutyl, s-butyl, and t-butyl).
  • Alkoxy refers to an "alkyl-oxy-" group, containing an alkyl moiety attached through an oxygen linking atom.
  • the term “(C 1 -C 4 )alkoxy” represents a saturated, straight or branched hydrocarbon moiety having at least 1 and up to 4 carbon atoms attached through an oxygen linking atom.
  • Exemplary "(C 1 -C 4 )alkoxy” groups include, but are not limited to, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, s-butoxy, and t -butoxy.
  • Aryl refers to a group or moiety comprising an aromatic, monocyclic or bicyclic hydrocarbon radical containing from 5 to 10 carbon ring atoms and having at least one aromatic ring.
  • aryl groups are phenyl, naphthyl, indenyl, and dihydroindenyl (indanyl).
  • Cycloalkyl refers to a non-aromatic, saturated, cyclic hydrocarbon group containing the specified number of carbon atoms.
  • C 3-6 cycloalkyl refers to a cycloalkyl group having from 3 to 6 carbon member atoms.
  • Cycloalkyl includes cyclopropyl, cyclopropenyl, cyclobutyl, cyclobutenyl, cyclopentyl, cyclopentenyl, cyclohexyl, and cyclohexenyl.
  • a heterocyclic group is a cyclic group having, as ring members, atoms of at least two different elements, which cyclic group may be saturated, partially unsaturated (non aromatic) or fully unsaturated (aromatic).
  • the terms "heterocyclic” or “heterocyclyl” includes heterocycloalkyl and heteroaryl groups.
  • heterocyclic, heterocyclyl, heteroaryl, and heterocycloalkyl are intended to encompass stable groups where a ring nitrogen heteroatom is optionally oxidized (e.g., heteroaryl groups containing an N oxide, such as oxo-pyridyl (pyridyl N oxide) and oxo-oxadiazolyl (oxo-4,5-dihydro-1,3,4-oxadiazolyl) or where a ring sulfur heteroatom is optionally oxidized (e.g., heterocycloalkyl groups containing sulfones or sulfoxide moieties, such as tetrahydrothienyl 1 oxide (tetrahydrothienyl sulfoxide, tetrahydrothiophenyl sulfoxide) and tetrahydrothienyl 1,1 dioxide (tetrahydrothienyl sulfone)).
  • heteroaryl groups containing an N oxide such as oxo-
  • C 4-8 heterocycloalkyl refers to a saturated, non-aromatic, monocyclic or bicyclic group containing 4-8 ring atoms, unless otherwise limited in size, containing one or more (generally one or two) heteroatom substitutions independently selected from oxygen, sulfur, and nitrogen.
  • Non-limited examples include, pyrrolidine, piperidine, morpholine, azepane, 1,4-oxazepane, 1,4-thiazepane, 1,4-thiazepane 1-oxide, 1,4-thiazepane 1,1-dioxide, thiomorpholine, thiomorpholine 1-oxide, and thiomorpholine 1,1-dioxide.
  • 'halogen' and 'halo' include fluorine, chlorine, bromine and iodine, and fluoro, chloro, bromo, and iodo, respectively.
  • Heteroaryl represents a group or moiety comprising an aromatic monocyclic radical, containing 5 to 6 ring atoms unless otherwise limited in size, including 1 to 4 heteroatoms independently selected from nitrogen, oxygen and sulfur. This term also encompasses 9- to 10-membered bicyclic heterocyclic-aryl groups containing either an aryl ring moiety fused to a heterocycloalkyl ring moiety or a heteroaryl ring moiety fused to a cycloalkyl ring moiety. This term also encompasses 9- to 10-membered fused bicyclic heteroaryl-aryl groups.
  • heteroaryls include, but are not limited to, furanyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl, thiazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiadiazolyl, isothiazolyl, pyridinyl (pyridyl), oxo-pyridyl (pyridyl-N-oxide), pyridazinyl, pyrazinyl, pyrimidinyl, triazinyl, benzofuranyl, isobenzofuryl, 2,3-dihydrobenzofuryl, 1,3-benzodioxolyl, dihydrobenzodioxinyl, benzothienyl, indolizinyl, indolyl, isoindolyl, dihydroindolyl, benzimi
  • Bicyclic heteroaryl groups include 6,5-fused heteroaryl (9-membered heteroaryl) and 6,6-fused heteroaryl (10-membered heteroaryl) groups.
  • 6,5-fused heteroaryl (9-membered heteroaryl) groups include benzothienyl, benzofuranyl, indolyl, indolinyl, isoindolyl, isoindolinyl, indazolyl, indolizinyl, isobenzofuryl, 2,3-dihydrobenzofuryl, benzoxazolyl, benzthiazolyl, benzimidazolyl, benzoxadiazolyl, benzthiadiazolyl, benzotriazolyl, 1,3-benzoxathiol-2-on-yl (2-oxo-1,3-benzoxathiolyl), purinyl and imidazopyridinyl.
  • 6,6-fused heteroaryl (10-membered heteroaryl) groups include quinolyl, isoquinolyl, phthalazinyl, naphthridinyl (1,5-naphthyridinyl, 1,6-naphthyridinyl, 1,7-naphthyridinyl, 1,8-naphthyridinyl), quinazolinyl, quinoxalinyl, 4H-quinolizinyl, tetrahydroquinolinyl, cinnolinyl, and pteridinyl.
  • Hydroxo or “hydroxyl” is intended to mean the radical -OH.
  • cyano refers to the group -CN.
  • Substituted in reference to a group indicates that one or more hydrogen atom attached to a member atom within the group is replaced with a substituent selected from the group of defined substituents. It should be understood that the term “substituted” includes the implicit provision that such substitution be in accordance with the permitted valence of the substituted atom and the substituent and that the substitution results in a stable compound (i.e. one that does not spontaneously undergo transformation such as by rearrangement, cyclization, or elimination and that is sufficiently robust to survive isolation from a reaction mixture). When it is stated that a group may contain one or more substituents, one or more (as appropriate) member atoms within the group may be substituted. In addition, a single member atom within the group may be substituted with more than one substituent as long as such substitution is in accordance with the permitted valence of the atom. Suitable substituents are defined herein for each substituted or optionally substituted group.
  • the invention also includes various stereoisomers of the compounds of claim 1 and mixtures thereof.
  • the compounds according to claim 1 contain one or more asymmetric centers, also referred to as chiral centers, and may, therefore, exist as individual enantiomers, diastereomers, or other stereoisomeric forms, or as mixtures thereof. All such stereoisomeric forms are included within the present invention, including mixtures thereof.
  • Chiral centers may also be present in a substituent such as an alkyl group. Where the stereochemistry of a chiral center present in a compound according to claim 1, or in any chemical structure illustrated herein, is not specified the structure is intended to encompass any stereoisomer and all mixtures thereof. Thus, compounds according to claim 1 containing one or more chiral centers may be used as racemic mixtures, enantiomerically enriched mixtures, or as enantiomerically pure individual stereoisomers.
  • Individual stereoisomers of a compound according to claim 1 which contain one or more asymmetric centers may be resolved by methods known to those skilled in the art. For example, such resolution may be carried out (1) by formation of diastereoisomeric salts, complexes or other derivatives; (2) by selective reaction with a stereoisomer-specific reagent, for example by enzymatic oxidation or reduction; or (3) by gas-liquid or liquid chromatography in a chiral environment, for example, on a chiral support such as silica with a bound chiral ligand or in the presence of a chiral solvent.
  • stereoisomers may be synthesized by asymmetric synthesis using optically active reagents, substrates, catalysts or solvents, or by converting one enantiomer to the other by asymmetric transformation.
  • references herein to a compound of Formula (I) or a compound of claim 1 or a pharmaceutically acceptable salt thereof includes a compound of Formula (I) or claim 1 as a free base [or acid, as appropriate], or as a pharmaceutically acceptable salt thereof.
  • the invention is directed to a compound of claim 1.
  • the invention is directed to a pharmaceutically acceptable salt of a compound of claim 1.
  • the invention is directed to a compound of claim 1 or a pharmaceutically acceptable salt thereof.
  • Compounds of Formula (I) have both a basic amine group and a carboxylic acid group and can consequently be in the form of a zwitterion, also known as an inner salt. Therefore, in one case the compound of Formula (I) or claim 1 is in a zwitterion form.
  • pharmaceutically acceptable refers to those compounds (including salts), materials, compositions, and dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, or other problem or complication, commensurate with a reasonable benefit/risk ratio.
  • Pharmaceutically acceptable salts include, amongst others, those described in Berge, J. Pharm. Sci., 1977, 66, 1-19 , or those listed in P H Stahl and C G Wermuth, editors, Handbook of Pharmaceutical Salts; Properties, Selection and Use, Second Edition Stahl/Wermuth: Wiley- VCH/VHCA, 2011 (see http://www.wiley.com/WileyCDA/WileyTitle/productCd-3906390519.html ).
  • pharmaceutically acceptable salts of the compounds according to Formula (I) or claim 1 may be prepared. These pharmaceutically acceptable salts may be prepared in situ during the final isolation and purification of the compound, or by separately treating the purified compound in its free acid or free base form with a suitable base or acid, respectively.
  • salt formation may include 1, 2 or more equivalents of acid.
  • Such salts would contain 1, 2 or more acid counterions, for example, a dihydrochloride salt.
  • Stoichiometric and non-stoichiometric forms of a pharmaceutically acceptable salt of a compound of claim 1 are included within the scope of the invention, including sub-stoichiometric salts, for example where a counterion contains more than one acidic proton.
  • Representative pharmaceutically acceptable acid addition salts include, but are not limited to, 4-acetamidobenzoate, acetate, adipate, alginate, ascorbate, aspartate, benzenesulfonate (besylate), benzoate, bisulfate, bitartrate, butyrate, calcium edetate, camphorate, camphorsulfonate (camsylate), caprate (decanoate), caproate (hexanoate), caprylate (octanoate), cinnamate, citrate, cyclamate, digluconate, 2,5-dihydroxybenzoate, disuccinate, dodecylsulfate (estolate), edetate (ethylenediaminetetraacetate), estolate (lauryl sulfate), ethane-1,2-disulfonate (edisylate), ethanesulfonate (esylate), formate, fumarate, galactarate (
  • Representative pharmaceutically acceptable base addition salts include, but are not limited to, aluminium, 2-amino-2-(hydroxymethyl)-1,3-propanediol (TRIS, tromethamine), arginine, benethamine ( N -benzylphenethylamine), benzathine ( N , N'- dibenzylethylenediamine), bis -(2-hydroxyethyl)amine, bismuth, calcium, chloroprocaine, choline, clemizole (1-p chlorobenzyl-2-pyrrolildine-1'-ylmethylbenzimidazole), cyclohexylamine, dibenzylethylenediamine, diethylamine, diethyltriamine, dimethylamine, dimethylethanolamine, dopamine, ethanolamine, ethylenediamine, L-histidine, iron, isoquinoline, lepidine, lithium, lysine, magnesium, meglumine ( N -methylglucamine), piperazine, piperidine
  • a compound of Formula (I) or “the compound of Formula (I)” refers to one or more compounds according to Formula (I).
  • the compound of Formula (I) may exist in solid or liquid form.
  • a compound of claim 1 or “the compound of claim 1” refers to one or more compounds according to claim 1.
  • the compound of claim 1 may exist in solid or liquid form. In the solid state, it may exist in crystalline or noncrystalline form, or as a mixture thereof.
  • pharmaceutically acceptable solvates may be formed from crystalline compounds wherein solvent molecules are incorporated into the crystalline lattice during crystallization.
  • Solvates may involve non-aqueous solvents such as, but not limited to, ethanol, isopropanol, DMSO, acetic acid, ethanolamine, or ethyl acetate, or they may involve water as the solvent that is incorporated into the crystalline lattice. Solvates wherein water is the solvent incorporated into the crystalline lattice are typically referred to as "hydrates.” Hydrates include stoichiometric hydrates as well as compositions containing variable amounts of water. The invention includes all such solvates.
  • polymorphs may exhibit polymorphism (i.e. the capacity to occur in different crystalline structures). These different crystalline forms are typically known as "polymorphs.”
  • the invention includes all such polymorphs. Polymorphs have the same chemical composition but differ in packing, geometrical arrangement, and other descriptive properties of the crystalline solid state. Polymorphs, therefore, may have different physical properties such as shape, density, hardness, deformability, stability, and dissolution properties. Polymorphs typically exhibit different melting points, IR spectra, and X-ray powder diffraction patterns, which may be used for identification.
  • polymorphs may be produced, for example, by changing or adjusting the reaction conditions or reagents, used in making the compound. For example, changes in temperature, pressure, or solvent may result in polymorphs. In addition, one polymorph may spontaneously convert to another polymorph under certain conditions.
  • the subject invention also includes isotopically-labelled compounds, which are identical to those recited in claim 1and following, but for the fact that one or more atoms are replaced by an atom having an atomic mass or mass number different from the atomic mass or mass number usually found in nature.
  • isotopes that can be incorporated into compounds of the invention and pharmaceutically acceptable salts thereof include isotopes of hydrogen, carbon, nitrogen, oxygen, phosphorous, sulphur, fluorine, iodine, and chlorine, such as 2 H, 3 H, 11 C, 13 C, 14 C, 15 N, 17 O, 18 O, 31 P, 32 P, 35 S, 18 F, 36 Cl, 123 I and 125 I.
  • Isotopically-labelled compounds of the present invention for example those into which radioactive isotopes such as 3 H, 14 C are incorporated, are useful in drug and/or substrate tissue distribution assays. Tritiated, i.e., 3 H, and carbon-14, i.e., 14 C, isotopes are particularly preferred for their ease of preparation and detectability.
  • 11 C and 18 F isotopes are particularly useful in PET (positron emission tomography), and 125 I isotopes are particularly useful in SPECT (single photon emission computerized tomography), all useful in brain imaging.
  • substitution with heavier isotopes such as deuterium, i.e., 2 H can afford certain therapeutic advantages resulting from greater metabolic stability, for example increased in vivo half-life or reduced dosage requirements and, hence, may be preferred in some circumstances.
  • Isotopically labeled compounds of claim 1and following of this invention can generally be prepared by carrying out the procedures disclosed in the Schemes and/or in the Examples below, by substituting a readily available isotopically labeled reagent for a non-isotopically labeled reagent.
  • a substituent described herein is not compatible with the synthetic methods described herein, the substituent may be protected with a suitable protecting group that is stable to the reaction conditions.
  • the protecting group may be removed at a suitable point in the reaction sequence to provide a desired intermediate or target compound.
  • Suitable protecting groups and the methods for protecting and de-protecting different substituents using such suitable protecting groups are well known to those skilled in the art; examples of which may be found in T. Greene and P. Wuts, Protecting Groups in Chemical Synthesis (3rd ed.), John Wiley & Sons, NY (1999 ).
  • a substituent may be specifically selected to be reactive under the reaction conditions used. Under these circumstances, the reaction conditions convert the selected substituent into another substituent that is either useful as an intermediate compound or is a desired substituent in a target compound.
  • Scheme 1 shows an alternate general scheme for the preparation of 5-bromo-4-methyl-1-methyl-1H-benzo[d][1,2,3]triazole.
  • R 1 is C 1-3 alkyl or -(CH 2 ) 2 ⁇ O ⁇ (CH 2 ) 2 -OR 4 .
  • DPPA 3-methyl-2-nitrobenzoic acid
  • DPPA 3-methyl-2-nitrobenzoic acid
  • compound 2 could be prepared from the appropriate aniline compound.
  • Alkylation of the carbamate with an alkyl iodide provides intermediate 3.
  • Deprotection of the amine with TFA and bromination with NBS provides intermediate 5.
  • Reduction of the nitro to the aniline and diazotization and cyclization provides the required triazole 7.
  • Scheme 2 represents a general scheme for the preparation of compounds according to Formula (I).
  • the triazole depicted as starting material is either commercially available or may be synthesized from readily available materials. Reaction conditions are as described above in the scheme; however, the skilled artisan will appreciate that certain modifications in the reaction conditions and/or reagents used are possible.
  • sulfonamides like 5 may be synthesized via conversion of the benzylic alcohol of 4 to a leaving group such as, but not limited to, mesylate, tosylate, chloride, bromide, or iodide followed by reaction with the requisite amine NHR 6 and subsequent reaction with a sulfonylating reagent such as a sulfonyl chloride.
  • Scheme 3 represents a general scheme for the preparation of compounds according to formula (I).
  • the starting material 1 can be synthesized from readily available materials. Reaction conditions are as described above in the scheme; however, the skilled artisan will appreciate that certain modifications in the reaction conditions and/or reagents used are possible.
  • Scheme 4 represents a general scheme for the preparation of sulfonamide 4.
  • amino alcohol 2 and substituted 2-cholorobenzene-1-sulfonyl chloride depicted as starting material are commercially available or may be synthesized from readily available materials.
  • Reaction conditions are as described above in the scheme; however, the skilled artisan will appreciate that certain modifications in the reaction conditions and/or reagents used are possible.
  • Scheme 5 represents a general scheme for the preparation of compounds according to Formula (I).
  • Substituted 2-bromo or chloro benzene-sulfonyl chloride 1 is either commercially available or may be synthesized from readily available materials. Reaction conditions are as described above in the scheme; however, the skilled artisan will appreciate that certain modifications in the reaction conditions and/or reagents used are possible.
  • Compound 4 was then resolved by Chiral SFC to give single isomer 5 and 6.
  • Scheme 6 represents a general scheme for the preparation of (R)-4-ethyl-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazepine 1,1-dioxide, used in the invention.
  • the 2-chloropyridine-3-sulfonyl chloride depicted as starting material is commercially available. Reaction with the appropriate amino alcohol followed by displacement of the chloride with a base provides the required intermediate 3.
  • Scheme 7 represents a general scheme for the preparation of sulfonamide 4.
  • amino alcohol 2 and substituted 2-cholorobenzene-1-sulfonyl chloride depicted as starting material are commercially available or may be synthesized from readily available materials.
  • Reaction conditions are as described above in the scheme; however, the skilled artisan will appreciate that certain modifications in the reaction conditions and/or reagents used are possible.
  • Sulfonamide formation under basic conditions with the appropriate amino alcohol and commercially available 2-chloro-pyridine-3-sulfonyl chloride to give intermediate 3, followed by displacement of the chloride with potassium tert-butoxide provides the required intermediate 4.
  • Scheme 8 represents a general scheme for the preparation of (R)-2-Ethyl-2,3,4,5-tetrahydropyrido[2,3- f ][1,4]oxazepine, hydrochloride 7, used in the invention. Reaction conditions are as described above in the scheme; however, the skilled artisan will appreciate that certain modifications in the reaction conditions and/or reagents used are possible.
  • the (R)-1-azidobutan-2-ol 2 is prepared from the commercially available (R)-2-ethyloxirane 1 and an azide source such as sodium azide. The azide can be reduced under hydrogenation conditions and a catalyst such as palladium on carbon to provide 3.
  • 3 can be prepared directly from the reaction of (R)-2-ethyloxirane and an ammonia source such as ammonium hydroxide.
  • a reductive amination reaction is then performed using the commercially available 3-fluoropicolinaldehyde 4 and 3, using sodium borohydride. Displacement of the fluoride with the alcohol using potassium-t-butoxide as base followed by amidation of the amine with Boc anhydride provides 6. The protected amine is deprotected with a suitable acid such as HCI to provide the intermediate 7.
  • Scheme 9 represents a general scheme for the preparation of (R)-3-(1,4-Dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydropyrido[2,3-f][1,4]oxazepin-4(5H)-yl)methyl)-4-methylphenyl)-N-(pyridin-3-yl)propanamide, formic acid salt 7, used in the invention.
  • Reaction conditions are as described above in the scheme; however, the skilled artisan will appreciate that certain modifications in the reaction conditions and/or reagents used are possible.
  • N ,3-Dimethyl-2-nitroaniline 2 was prepared by amination of the commercially available 1-fluoro-3-methyl-2-nitrobenzene 1. Bromination of 2 is achieved with NBS to provide 3. Iron powder in HOAc/EtOH was used for the nitro reduction of 3 to provide 4. Diazotization and cyclization provides the triazole 5. Treatment of triazole 5 with tert -butyl acrylate in the presence of palladium (II) acetate and tri-o-tolylphosphine in presence of a suitable solvent produces the desired Heck cross-coupling product 6.
  • compound 6 may also be obtained via a Horner Wadsworth Emmons or Wittig olefination reaction starting from the appropriate aldehyde of compound 5.
  • Hydrolysis of the t-butyl ester with TFA and amidation with the chiral auxiliary (S)-4-phenyloxazolidin-2-one provides 8.
  • Further transformation of the olefin 8 can be achieved through a copper mediated Grignard reaction to provide 9.
  • the conversion of the amide chiral auxiliary to the ethyl ester 10 is achieved with magnesium bromide in ethanol. Removal of the para-methoxybenzyl group with DDQ furnishes the benzyl alcohol 6 which is converted to the chloride with thionyl chloride.
  • the chloride is then displaced with sulfonamide 12 to provide 13.
  • the benzylic alcohol may also be displaced by a suitably acidic nucleophile, such as a sulfonamide, under Mitsunobu conditions using tri-n-butyl phosphine and ADDP
  • the ester is hydrolysed under basic conditions and an amidation reaction is performed on the carboxylic acid with a suitable amine such as 3-aminopyridine using an amide coupling reagent such as HATU to provide 15.
  • the amide could be formed by activation of the carboxylic acid with a chlorinating reagent like thionyl chloride, and subsequent displacement of the chloride with a suitable amine.
  • Scheme 10 represents a general scheme for the preparation of phenyl (E)-N-(tert-butyl)-N'-(pyridin-3-yl)carbamimidothioate, used in the invention.
  • pyridin-3-amine depicted as starting material is commercially available.
  • the reaction with 2-isocyano-2-methylpropane and S-phenyl benzenesulfonothioate in 2-methyltetrahydrofuran is heated with copper(I) iodide and provides the required intermediate 2.
  • Scheme 11 shows an general scheme for the preparation of 5-Bromo-1-ethyl-7-methoxy-4-methyl-1H-benzo[d][1,2,3]triazole.
  • the triazole depicted as starting material is either commercially available or may be synthesized from readily available materials.
  • Reaction conditions are as described above in the scheme; however, the skilled artisan will appreciate that certain modifications in the reaction conditions and/or reagents used are possible.
  • Scheme 12 represents a general scheme for the preparation of compounds according to Formula (I).
  • the triazole depicted as starting material is either commercially available or may be synthesized from readily available materials. Reaction conditions are as described above in the scheme; however, the skilled artisan will appreciate that certain modifications in the reaction conditions and/or reagents used are possible.
  • sulfonamides like 5 may be synthesized via conversion of the benzylic alcohol of 4 to a leaving group such as, but not limited to, mesylate, tosylate, chloride, bromide, or iodide followed by reaction with the requisite amine NHR 6 and subsequent reaction with a sulfonylating reagent such as a sulfonyl chloride.
  • Scheme 13 represents a general scheme for the preparation of compounds according to Formula (I).
  • Benzyl alcohols 1 are activated by typical amidation activation methods including, but not limited to, thionyl chloride, amide coupling reagents such as HATU, 1-(fluoro(pyrrolidin-1-yl)methylene)pyrrolidin-1-ium hexafluorophosphate(V) (BTFFH) or phenyl (E)-N-(tert-butyl)-N'-(pyridin-3-yl)carbamimidothioate.
  • Amines R 5 NH 2 are either combined during the activation process or after a period of time, to provide the desired amides.
  • Scheme 14 represents a general scheme for the preparation of 1-(thiazol-2-ylmethyl)-1H-tetrazol-5-amine.
  • the tetrazole 2 is prepared from the commercially available thiazol-2-ylmethanamine using sodium azide and triethylorthoformate.
  • the amino tetrazole is then prepared by addition of DMSO to a solution of 2, sodium azide and NaOH in IPA to provide 3.
  • Scheme 15 represents a general scheme for the preparation of compounds according to Formula (I).
  • Carboxylic acid 1 is prepared in a manner analogous to the method described in WO 2015/092713 , Scheme 15 published June 25, 2015.
  • the carboxazide 2 is prepared from the reaction of the carboxylic acid 1 with DPPA and TEA in toluene. A rearrangement is performed on the carboxazide to afford the tertiary amine 3.
  • the amide 4 is formed from the amine 3 by activation of a carboxylic acid, R 3 CO 2 H, with a suitable coupling agent like HATU.
  • the amide could be formed by activation of the carboxylic acid with a chlorinating reagent like thionyl chloride, and subsequent displacement of the chloride with the amine 3 to afford amide 4.
  • Scheme 16 represents a general scheme for the preparation of compounds according to Formula I. Reaction conditions are as described above in the scheme; however, the skilled artisan will appreciate that certain modifications in the reaction conditions and/or reagents used are possible.
  • Carboxylic acid 1 can be reduced to the benzyl alcohol in THF using a solution of borane-methyl sulfide complex to provide 2.
  • Alkylation of the alcohol using a strong base and a suitable protecting group provides intermediate 3.
  • Formylation of the bromide using n-butyl lithium and DMF affords 4.
  • Intermediate 5, arises from treatment of aldehyde 4 with the appropriate silylketene acetal in the presence of lithium chloride.
  • Intermediate 6 can be prepared by treatement of the alcohol with a strong base, like sodium hydride, followed by addition of 3-bromoprop-1-yne. Deprotection of the benzyl alcohol can be achieved using an oxidative reagent such as DDQ to provide 7.
  • a strong base like sodium hydride
  • DDQ oxidative reagent
  • Scheme 17 represents a general scheme for the preparation of compounds according to Formula (I). Reaction conditions are as described above in the scheme; however, the skilled artisan will appreciate that certain modifications in the reaction conditions and/or reagents used are possible.
  • Ether linked alkyne intermediate 1 was converted into cyclicsulfonamide substituted alkyne intermediate 2 by either treatment with cyclic sulfonamide, polymer supported PPh 3 and DIAD in THF or first treated with SOCl2 in DCM then reaction with cyclicsulfonamide and NaH in DMF.
  • Intermediate 2 was then converted to desired product 3 by either treatment with R 1 I or R 1 Br and NaN 3 , CuI, DIEA in i-PrOH/THF/H 2 O then followed by hydrolysis with NaOH in MeOH/H 2 O or reaction with R 1 N 3 , CuI, DIEA in i-PrOH/THF/H 2 O followed by hydrolysis with NaOH in MeOH/H 2 O.
  • the compounds according to Formula I are NRF2 activators, and are useful in the treatment or prevention of human diseases that exhibit oxidative stress components such as respiratory and non-respiratory disorders, including COPD, asthma, ALI, ARDS, fibrosis, chronic asthma and acute asthma, lung disease secondary to environmental exposures, acute lung infection, chronic lung infection, ⁇ 1 antitrypsin disease, cystic fibrosis, autoimmune diseases, diabetic nephropathy, chronic kidney disease, sepsis-induced acute kidney injury, acute kidney injury (AKI), kidney disease or malfunction seen during kidney transplantation, Pulmonary Arterial Hypertension, atherosclerosis, hypertension, heart failure, Parkinson's disease (PD), Alzheimer's disease (AD), Friedreich's Ataxia (FA), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), inflammatory bowel disease, colon cancer, neovascular (dry) AMD and neovascular (wet) AMD, eye injury, Fuchs Endothelial Corneal
  • the biological activity of the compounds according to Formula I can be determined using any suitable assay for determining the activity of a candidate compound as a NRF2 antagonist, as well as tissue and in vivo models.
  • NAD(P)H:quinone oxidoreductase 1 also called DT diaphorase
  • NQO1 quinone oxidoreductase 1
  • DT diaphorase is a homodimeric FAD-containing enzyme that catalyzes obligatory NAD(P)H-dependent two-electron reductions of quinones and protects cells against the toxic and neoplastic effects of free radicals and reactive oxygen species arising from one-electron reductions.
  • the transcription of NQO1 is finely regulated by NRF2, and thus NQO1 activity is a good marker for NRF2 activation.
  • frozen BEAS-2B cells ATCC are thawed in a water bath, counted, and re-suspended at a concentration of 250,000 cells/mL.
  • Fifty microliters of cells are plated in 384 well black clear-bottomed plates. Plates are incubated at 37°C, 5% CO 2 overnight. On day two, plates are centrifuged and 50nL of compound or controls are added to the cells. Plates are then incubated at 37°C, 5% CO 2 for 48 hours. On day four, medium is aspirated from the plate and crude cell lysates are made by adding 13uL of 1X Cell Signaling Technologies lysis buffer with 1 Complete, Mini, EDTA-free Protease Inhibitor Tablet (Roche) for each 10mL of lysis buffer. After lysis plates are incubated for 20 minutes at room temperature.
  • MTT cocktail is prepared (Prochaska et. al. 1998) for measurement of NQO1 activity. Fifty microliters of MTT cocktail is added to each well, plate is centrifuged, and analyzed on an Envision plate reader (Perkin Elmer) using Absorbance 570nm label for 30 minutes. Product formation is measured kinetically and the EC 50 of NQO1 specific activity induction is calculated by plotting the change in absorbance (Delta OD/min) versus the log of compound concentration followed by 3-parameter fitting.
  • the compounds of Formula (I) are useful in treating respiratory and non-respiratory disorders, including COPD, asthma, ALI, ARDS, fibrosis, chronic asthma, acute asthma, lung disease secondary to environmental exposures, acute lung infection, chronic lung infection, ⁇ 1 antitrypsin disease, cystic fibrosis, autoimmune diseases, diabetic nephropathy, chronic kidney disease, sepsis-induced acute kidney injury, acute kidney injury (AKI), kidney disease or malfunction seen during kidney transplantation, Pulmonary Arterial Hypertension, atherosclerosis, hypertension, heart failure, acute coronary syndrome, myocardial infarction, myocardial repair, cardiac remodeling, cardiac arrhythmias, heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, diabetic cardiomyopathy, Parkinson's disease (PD), Alzheimer's disease (AD), Friedreich's Ataxia (FA), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), inflammatory bowel disease, colon cancer, neovascular (dry
  • the compounds of Formula (I) are useful in treating respiratory disorders including COPD, asthma, including chronic asthma and acute asthma.
  • the compounds of Formula (I) are useful in treating hypertension, heart failure, acute coronary syndrome, myocardial infarction, myocardial repair, cardiac remodeling, cardiac arrhythmias, heart failure with preserved ejection fraction, heart failure with reduced ejection fraction and diabetic cardiomyopathy.
  • the methods of treatment described herein comprise administering a safe and effective amount of a compound according to Formula I or a pharmaceutically-acceptable salt thereof to a patient in need thereof.
  • treat in reference to a condition means: (1) to ameliorate or prevent the condition or one or more of the biological manifestations of the condition, (2) to interfere with (a) one or more points in the biological cascade that leads to or is responsible for the condition or (b) one or more of the biological manifestations of the condition, (3) to alleviate one or more of the symptoms or effects associated with the condition, or (4) to slow the progression of the condition or one or more of the biological manifestations of the condition.
  • prevention is not an absolute term. In medicine, “prevention” is understood to refer to the prophylactic administration of a drug to substantially diminish the likelihood or severity of a condition or biological manifestation thereof, or to delay the onset of such condition or biological manifestation thereof.
  • safe and effective amount in reference to a compound of the invention or other pharmaceutically-active agent means an amount of the compound sufficient to treat the patient's condition but low enough to avoid serious side effects (at a reasonable benefit/risk ratio) within the scope of sound medical judgment.
  • a safe and effective amount of a compound will vary with the particular compound chosen (e.g. consider the potency, efficacy, and half-life of the compound); the route of administration chosen; the condition being treated; the severity of the condition being treated; the age, size, weight, and physical condition of the patient being treated; the medical history of the patient to be treated; the duration of the treatment; the nature of concurrent therapy; the desired therapeutic effect; and like factors, but can nevertheless be routinely determined by the skilled artisan.
  • patient refers to a human or other animal.
  • the compounds of the invention may be administered by any suitable route of administration, including both systemic administration and topical administration.
  • Systemic administration includes oral administration, parenteral administration, transdermal administration, rectal administration, and administration by inhalation.
  • Parenteral administration refers to routes of administration other than enteral, transdermal, or by inhalation, and is typically by injection or infusion.
  • Parenteral administration includes intravenous, intramuscular, and subcutaneous injection or infusion.
  • Inhalation refers to administration into the patient's lungs whether inhaled through the mouth or through the nasal passages.
  • Topical administration includes application to the skin as well as intraocular, otic, intravaginal, and intranasal administration.
  • the compounds of the invention may be administered once or according to a dosing regimen wherein a number of doses are administered at varying intervals of time for a given period of time. For example, doses may be administered one, two, three, or four times per day. Doses may be administered until the desired therapeutic effect is achieved or indefinitely to maintain the desired therapeutic effect. Suitable dosing regimens for a compound of the invention depend on the pharmacokinetic properties of that compound, such as absorption, distribution, and half-life, which can be determined by the skilled artisan.
  • suitable dosing regimens including the duration such regimens are administered, for a compound of the invention depend on the condition being treated, the severity of the condition being treated, the age and physical condition of the patient being treated, the medical history of the patient to be treated, the nature of concurrent therapy, the desired therapeutic effect, and like factors within the knowledge and expertise of the skilled artisan. It will be further understood by such skilled artisans that suitable dosing regimens may require adjustment given an individual patient's response to the dosing regimen or over time as individual patient needs change.
  • Typical daily dosages may vary depending upon the particular route of administration chosen. Typical dosages for oral administration range from 1 mg to 1000 mg per person per day. Preferred dosages are 1 - 500 mg once daily, more preferred is 1 - 100 mg per person per day. IV dosages range form 0.1-000mg/day, preferred is 0.1-500mg/day, and more preferred is 0.1-100mg/day. Inhaled daily dosages range from 10ug-10mg/day, with preferred 10ug-2mg/day, and more preferred 50uug-500ug/day.
  • a prodrug of a compound of the invention is a functional derivative of the compound which, upon administration to a patient, eventually liberates the compound of the invention in vivo.
  • Administration of a compound of the invention as a prodrug may enable the skilled artisan to do one or more of the following: (a) modify the onset of the compound in vivo; (b) modify the duration of action of the compound in vivo; (c) modify the transportation or distribution of the compound in vivo; (d) modify the solubility of the compound in vivo; and (e) overcome a side effect or other difficulty encountered with the compound.
  • Typical functional derivatives used to prepare prodrugs include modifications of the compound that are chemically or enzymatically cleaved in vivo. Such modifications, which include the preparation of phosphates, amides, ethers, esters, thioesters, carbonates, and carbamates, are well known to those skilled in the art.
  • the compounds of the invention will normally, but not necessarily, be formulated into pharmaceutical compositions prior to administration to a patient. Accordingly, in another aspect the invention is directed to pharmaceutical compositions comprising a compound of the invention and one or more pharmaceutically-acceptable excipients.
  • compositions of the invention may be prepared and packaged in bulk form wherein a safe and effective amount of a compound of the invention can be extracted and then given to the patient such as with powders or syrups.
  • the pharmaceutical compositions of the invention may be prepared and packaged in unit dosage form wherein each physically discrete unit contains a safe and effective amount of a compound of the invention.
  • the pharmaceutical compositions of the invention typically contain from 1 mg to 1000 mg.
  • compositions of the invention typically contain one compound of the invention. However, in certain embodiments, the pharmaceutical compositions of the invention contain more than one compound of the invention. For example, in certain embodiments the pharmaceutical compositions of the invention contain two compounds of the invention. In addition, the pharmaceutical compositions of the invention may optionally further comprise one or more additional pharmaceutically active compounds.
  • pharmaceutically-acceptable excipient means a pharmaceutically acceptable material, composition or vehicle involved in giving form or consistency to the pharmaceutical composition.
  • Each excipient must be compatible with the other ingredients of the pharmaceutical composition when commingled such that interactions which would substantially reduce the efficacy of the compound of the invention when administered to a patient and interactions which would result in pharmaceutical compositions that are not pharmaceutically acceptable are avoided.
  • each excipient must of course be of sufficiently high purity to render it pharmaceutically-acceptable.
  • dosage forms include those adapted for (1) oral administration such as tablets, capsules, caplets, pills, troches, powders, syrups, elixers, suspensions, solutions, emulsions, sachets, and cachets; (2) parenteral administration such as sterile solutions, suspensions, and powders for reconstitution; (3) transdermal administration such as transdermal patches; (4) rectal administration such as suppositories; (5) inhalation such as dry powders, aerosols, suspensions, and solutions; and (6) topical administration such as creams, ointments, lotions, solutions, pastes, sprays, foams, and gels.
  • oral administration such as tablets, capsules, caplets, pills, troches, powders, syrups, elixers, suspensions, solutions, emulsions, sachets, and cachets
  • parenteral administration such as sterile solutions, suspensions, and powders for reconstitution
  • transdermal administration such as transdermal patches
  • rectal administration such as
  • Suitable pharmaceutically-acceptable excipients will vary depending upon the particular dosage form chosen.
  • suitable pharmaceutically-acceptable excipients may be chosen for a particular function that they may serve in the composition.
  • certain pharmaceutically-acceptable excipients may be chosen for their ability to facilitate the production of uniform dosage forms.
  • Certain pharmaceutically-acceptable excipients may be chosen for their ability to facilitate the production of stable dosage forms.
  • Certain pharmaceutically-acceptable excipients may be chosen for their ability to facilitate the carrying or transporting of the compound or compounds of the invention once administered to the patient from one organ, or portion of the body, to another organ, or portion of the body.
  • Certain pharmaceutically-acceptable excipients may be chosen for their ability to enhance patient compliance.
  • Suitable pharmaceutically-acceptable excipients include the following types of excipients: diluents, fillers, binders, disintegrants, lubricants, glidants, granulating agents, coating agents, wetting agents, solvents, co-solvents, suspending agents, emulsifiers, sweeteners, flavoring agents, flavor masking agents, coloring agents, anticaking agents, hemectants, chelating agents, plasticizers, viscosity increasing agents, antioxidants, preservatives, stabilizers, surfactants, and buffering agents.
  • excipients include the following types of excipients: diluents, fillers, binders, disintegrants, lubricants, glidants, granulating agents, coating agents, wetting agents, solvents, co-solvents, suspending agents, emulsifiers, sweeteners, flavoring agents, flavor masking agents, coloring agents, anticaking agents, hemectants, chel
  • Skilled artisans possess the knowledge and skill in the art to enable them to select suitable pharmaceutically-acceptable excipients in appropriate amounts for use in the invention.
  • resources that are available to the skilled artisan which describe pharmaceutically-acceptable excipients and may be useful in selecting suitable pharmaceutically-acceptable excipients. Examples include Remington's Pharmaceutical Sciences (Mack Publishing Company ), The Handbook of Pharmaceutical Additives (Gower Publishing Limited ), and The Handbook of Pharmaceutical Excipients (the American Pharmaceutical Association and the Pharmaceutical Press ).
  • compositions of the invention are prepared using techniques and methods known to those skilled in the art. Some of the methods commonly used in the art are described in Remington's Pharmaceutical Sciences (Mack Publishing Company ).
  • the invention is directed to a solid oral dosage form such as a tablet or capsule comprising a safe and effective amount of a compound of the invention and a diluent or filler.
  • Suitable diluents and fillers include lactose, sucrose, dextrose, mannitol, sorbitol, starch (e.g. corn starch, potato starch, and pre-gelatinized starch), cellulose and its derivatives (e.g. microcrystalline cellulose), calcium sulfate, and dibasic calcium phosphate.
  • the oral solid dosage form may further comprise a binder. Suitable binders include starch (e.g.
  • the oral solid dosage form may further comprise a disintegrant. Suitable disintegrants include crospovidone, sodium starch glycolate, croscarmelose, alginic acid, and sodium carboxymethyl cellulose.
  • the oral solid dosage form may further comprise a lubricant. Suitable lubricants include stearic acid, magnesium stearate, calcium stearate, and talc.
  • the invention is directed to a dosage form adapted for administration to a patient parenterally including subcutaneous, intramuscular, intravenous or intradermal.
  • Pharmaceutical formulations adapted for parenteral administration include aqueous and non-aqueous sterile injection solutions which may contain anti-oxidants, buffers, bacteriostats, and solutes that render the formulation isotonic with the blood of the intended recipient; and aqueous and non-aqueous sterile suspensions which may include suspending agents and thickening agents.
  • the formulations may be presented in unit-dose or multi-dose containers, for example sealed ampules and vials, and may be stored in a freeze-dried (lyophilized) condition requiring only the addition of the sterile liquid carrier, for example water for injections, immediately prior to use.
  • sterile liquid carrier for example water for injections, immediately prior to use.
  • Extemporaneous injection solutions and suspensions may be prepared from sterile powders, granules, and tablets.
  • the invention is directed to a dosage form adapted for administration to a patient by inhalation.
  • the compound of the invention may be inhaled into the lungs as a dry powder, an aerosol, a suspension, or a solution.
  • Dry powder compositions for delivery to the lung by inhalation typically comprise a compound of the invention as a finely divided powder together with one or more pharmaceutically acceptable excipients as finely divided powders.
  • Pharmaceutically acceptable excipients particularly suited for use in dry powders are known to those skilled in the art and include lactose, starch, mannitol, and mono-, di-, and polysaccharides.
  • the dry powder compositions for use in accordance with the present invention are administered via inhalation devices.
  • such devices can encompass capsules and cartridges of for example gelatin, or blisters of, for example, laminated aluminum foil.
  • each capsule, cartridge or blister may contain doses of composition according to the teachings presented herein.
  • inhalation devices can include those intended for unit dose or multi-dose delivery of composition, including all of the devices set forth herein.
  • the formulation can be pre-metered (e.g., as in Diskus ® , see GB2242134 , U.S. Patent Nos.
  • the Diskus ® inhalation device comprises an elongate strip formed from a base sheet having a plurality of recesses spaced along its length and a lid sheet peelably sealed thereto to define a plurality of containers, each container having therein an inhalable formulation containing the compound optionally with other excipients and additive taught herein.
  • the peelable seal is an engineered seal, and in one embodiment the engineered seal is a hermetic seal.
  • the strip is sufficiently flexible to be wound into a roll.
  • the lid sheet and base sheet will preferably have leading end portions which are not sealed to one another and at least one of the leading end portions is constructed to be attached to a winding means.
  • the engineered seal between the base and lid sheets extends over their whole width.
  • the lid sheet may preferably be peeled from the base sheet in a longitudinal direction from a first end of the base sheet.
  • a dry powder composition may also be presented in an inhalation device which permits separate containment of two different components of the composition.
  • these components are administrable simultaneously but are stored separately, e.g., in separate pharmaceutical compositions, for example as described in WO 03/061743 A1 WO 2007/012871 A1 and/or WO2007/068896 , as well as U.S. Patent Nos. 8,113,199 , 8,161,968 , 8,511,304 , 8,534,281 , 8,746,242 and 9,333,310 .
  • an inhalation device permitting separate containment of components is an inhaler device having two peelable blister strips, each strip containing pre-metered doses in blister pockets arranged along its length, e.g., multiple containers within each blister strip, e.g., as found in ELLIPTA®.
  • Said device has an internal indexing mechanism which, each time the device is actuated, peels opens a pocket of each strip and positions the blisters so that each newly exposed dose of each strip is adjacent to the manifold which communicates with the mouthpiece of the device. When the patient inhales at the mouthpiece, each dose is simultaneously drawn out of its associated pocket into the manifold and entrained via the mouthpiece into the patient's respiratory tract.
  • a further device that permits separate containment of different components is DUOHALERTM of Innovata.
  • various structures of inhalation devices provide for the sequential or separate delivery of the pharmaceutical composition(s) from the device, in addition to simultaneous delivery.
  • Aerosols may be formed by suspending or dissolving a compound of the invention in a liquefied propellant.
  • Suitable propellants include halocarbons, hydrocarbons, and other liquefied gases.
  • Representative propellants include: trichlorofluoromethane (propellant 11), dichlorofluoromethane (propellant 12), dichlorotetrafluoroethane (propellant 114), tetrafluoroethane (HFA-134a), 1,1-difluoroethane (HFA-152a), difluoromethane (HFA-32), pentafluoroethane (HFA-12), heptafluoropropane (HFA- 227a), perfluoropropane, perfluorobutane, perfluoropentane, butane, isobutane, and pentane. Aerosols comprising a compound of the invention will typically be administered to a patient via a me
  • the aerosol may contain additional pharmaceutically acceptable excipients typically used with multiple dose inhalers such as surfactants, lubricants, cosolvents and other excipients to improve the physical stability of the formulation, to improve valve performance, to improve solubility, or to improve taste.
  • additional pharmaceutically acceptable excipients typically used with multiple dose inhalers such as surfactants, lubricants, cosolvents and other excipients to improve the physical stability of the formulation, to improve valve performance, to improve solubility, or to improve taste.
  • Suspensions and solutions comprising a compound of the invention may also be administered to a patient via a nebulizer.
  • the solvent or suspension agent utilized for nebulization may be any pharmaceutically acceptable liquid such as water, aqueous saline, alcohols or glycols, e.g., ethanol, isopropyl alcohol, glycerol, propylene glycol, polyethylene glycol, etc. or mixtures thereof.
  • Saline solutions utilize salts which display little or no pharmacological activity after administration.
  • organic salts such as alkali metal or ammonium halogen salts, e.g., sodium chloride, potassium chloride or organic salts, such as potassium, sodium and ammonium salts or organic acids, e.g., ascorbic acid, citric acid, acetic acid, tartaric acid, etc. may be used for this purpose.
  • alkali metal or ammonium halogen salts e.g., sodium chloride, potassium chloride or organic salts, such as potassium, sodium and ammonium salts or organic acids, e.g., ascorbic acid, citric acid, acetic acid, tartaric acid, etc.
  • organic acids e.g., ascorbic acid, citric acid, acetic acid, tartaric acid, etc.
  • compositions may be added to the suspension or solution.
  • the compound of the invention may be stabilized by the addition of an inorganic acid, e.g., hydrochloric acid, nitric acid, sulfuric acid and/or phosphoric acid; an organic acid, e.g., ascorbic acid, citric acid, acetic acid, and tartaric acid, etc., a complexing agent such as EDTA or citric acid and salts thereof; or an antioxidant such as antioxidant such as vitamin E or ascorbic acid.
  • Preservatives may be added such as benzalkonium chloride or benzoic acid and salts thereof.
  • Surfactant may be added particularly to improve the physical stability of suspensions. These include lecithin, disodium dioctylsulphosuccinate, oleic acid and sorbitan esters.
  • the compounds of Formula (I) and pharmaceutically acceptable salts thereof may be used in combination with one or more other agents which may be useful in the prevention or treatment of allergic disease, inflammatory disease, autoimmune disease, for example; antigen immunotherapy, anti-histamines, corticosteroids, (eg fluticasone propionate, fluticasone furoate, beclomethasone dipropionate, budesonide, ciclesonide, mometasone furoate, triamcinolone, flunisolide), NSAIDs, leukotriene modulators (e.g.
  • iNOS inhibitors e.g., montelukast, zafirlukast, pranlukast
  • iNOS inhibitors tryptase inhibitors, IKK2 inhibitors, p38 inhibitors, Syk inhibitors
  • protease inhibitors such as elastase inhibitors, integrin antagonists (e.g., beta-2 integrin antagonists), adenosine A2a agonists, mediator release inhibitors such as sodium chromoglycate, 5-lipoxygenase inhibitors (zyflo), DP1 antagonists, DP2 antagonists, PI3K delta inhibitors, ITK inhibitors, LP (lysophosphatidic) inhibitors or FLAP (5-lipoxygenase activating protein) inhibitors (e.g.
  • bronchodilators e.g., muscarinic antagonists, beta-2 agonists
  • methotrexate and similar agents
  • monoclonal antibody therapy such as anti-IgE, anti-TNF, anti-IL-5, anti-IL-6, anti-IL-12, anti-IL-1 and similar agents
  • cytokine receptor therapies e.g. etanercept and similar agents
  • antigen non-specific immunotherapies e.g. interferon or other cytokines/chemokines, chemokine receptor modulators such as CCR3, CCR4 or CXCR2 antagonists, other cytokine/chemokine agonists or antagonists, TLR agonists and similar agents).
  • the compounds may also be used in combination with agents for aiding transplantation including Cyclosporines, Tacrolimus, Mycophenolate mofetil, Prednisone, Azathioprine , Sirolimus, Daclizumab, Basiliximab, or OKT3.
  • agents for aiding transplantation including Cyclosporines, Tacrolimus, Mycophenolate mofetil, Prednisone, Azathioprine , Sirolimus, Daclizumab, Basiliximab, or OKT3.
  • diabetes may also be used in combination with agents for Diabetes: metformin (biguanides), meglitinides, sulfonylureas, DPP-4 inhibitors, Thiazolidinediones, Alpha-glucosidase inhibitors, Amylin mimetics, Incretin mimetics, and insulin.
  • metformin biguanides
  • meglitinides meglitinides
  • sulfonylureas DPP-4 inhibitors
  • Thiazolidinediones Thiazolidinediones
  • Alpha-glucosidase inhibitors Amylin mimetics
  • Incretin mimetics and insulin.
  • the compounds may be used in combination with antihypertensives such as diuretics, ACE inhibitors, ARBS, calcium channel blockers, and beta blockers.
  • antihypertensives such as diuretics, ACE inhibitors, ARBS, calcium channel blockers, and beta blockers.
  • One embodiment of the invention encompasses combinations comprising one or two other therapeutic agents.
  • the other therapeutic ingredient(s) may be used in the form of salts, for example as alkali metal or amine salts or as acid addition salts, or prodrugs, or as esters, for example lower alkyl esters, or as solvates, for example hydrates to optimize the activity and/or stability and/or physical characteristics, such as solubility, of the therapeutic ingredient.
  • the therapeutic ingredients may be used in optically pure form.
  • compositions comprising a combination as defined above together with a pharmaceutically acceptable diluent or carrier represent a further aspect of the invention.
  • the individual compounds of such combinations may be administered either sequentially or simultaneously in separate or combined pharmaceutical formulations.
  • the individual compounds will be administered simultaneously in a combined pharmaceutical formulation.
  • Appropriate doses of known therapeutic agents will readily be appreciated by those skilled in the art.
  • the invention thus provides, in a further aspect, a pharmaceutical composition comprising a combination of a compound of the invention together with another therapeutically active agent.
  • Preparative HPLC was performed using a Gilson or Waters Preparative System with variable wavelength UV detection or an Agilent Mass Directed AutoPrep (MDAP) system or Shimadzu PREP LC 20AP with both mass and variable wavelength UV detection.
  • MDAP Agilent Mass Directed AutoPrep
  • a variety of reverse phase columns e.g., Luna C18(2), SunFire C18, XBridge C18, Atlantics T3, Kromasil C18, Xbridge Phenyl-Hexyl columns were used in the purification with the choice of column support dependent upon the conditions used in the purification.
  • the compounds are eluted using a gradient of CH 3 CN or methanol and water.
  • Neutral conditions used an CH 3 CN and water gradient with no additional modifier
  • acidic conditions used an acid modifier, usually 0.1% TFA or 0.1% formic acid
  • basic conditions used a basic modifier, usually 0.1% NH 4 OH (added to the water) or 10 mM ammonium bicarbonate (added to the water), or 0.05 % NH 4 HCO 3 (added to water).
  • Analytical HPLC was run using an Agilent system or Waters Alliance HPLC with 2996 PDA detector, Waters Acquity UPLC-MS or Agilent Infinity 1290 with PDA or conducted on a Sunfire C18 column, alternative on XSELECT CSH C18 column using reverse phase chromatography with a CH 3 CN and water gradient with 0.1% formic acid modifier (added to each solvent) and basic conditions used a basic modifier, usually 5mM ammonium bicarbonate or 10 mM ammonium bicarbonate in water adjusted pH to 10 with ammonia solution.
  • a basic modifier usually 5mM ammonium bicarbonate or 10 mM ammonium bicarbonate in water adjusted pH to 10 with ammonia solution.
  • the compound was analyzed by LCMS using a Shimadzu LC system with UV 214 nm wavelength detection and H 2 O- CH 3 CN gradient elution (4-95% over 1.9min.) acidified to 0.02% TFA.
  • the reversed-phase column was a 2.1x20 mm Thermo Hypersil Gold C18 (1.9u particles) at 50°C.
  • the single quadrupole MS detector was either a Sciex 150EX or a Waters ZQ operated in positive-ion.
  • LC-MS was determined using either a PE Sciex Single Quadrupole 150EX LC-MS, or Waters ZQ Single Quadrupole, Waters 3100 Single Quadrupole, Agilent 6130 SQD or Agilent 6120 Single Quadrupole LC-MS instruments.
  • the compound is analyzed using a reverse phase column, e.g., Thermo Hypersil Gold C18 and/or Luna C18 eluted using a gradient of CH 3 CN and water with a low percentage of an acid modifier such as 0.02% or 0.1%TFA.
  • Preparative Chiral SFC was performed using a Thar/Waters Preparative SFC System with single wavelength UV detection system.
  • a variety of chiral SFC columns e.g. Chiralpak IA, IC, AY, AD, IF, OJ were used in the purification.
  • the compounds are eluted using supercritical fluid CO 2 and co-solvents, such as MeOH, EtOH, IPA, and combination of these solvent in different ratio based on the compound.
  • Modifiers (0.1% to 0.4% of TFA, NH 4 OH, DEA, TEA) can be used as needed.
  • Analytical Chiral SFC was run using a Thar/Waters SFC system with variable wavelength UV detection.
  • a variety of chiral SFC columns e.g. Chiralpak IA, IB, IC, ID, IF, AY, AD, OD, C2, AS, OJ, CCL4 were used in the purification.
  • the compounds are eluted using supercritical fluid CO 2 and co-solvents, such as MeOH, EtOH, IPA, and combination of these solvent in different ratio based on the compound selectivity. Modifiers (0.1% to 0.4% of TFA, NH 4 OH,DEA, TEA) would be used as needed.
  • Celite ® is a filter aid composed of acid-washed diatomaceous silica, and is a registered trademark of Manville Corp., Denver, Colorado.
  • Isolute ® is a functionalized silica gel based sorbent, and is a registered trademark of Biotage AB Corp., Sweden.
  • Heating of reaction mixtures with microwave irradiation was carried out on a Biotage Initiator ® microwave reactor, typically employing the high absorbance setting.
  • Cartridges or columns containing polymer based functional groups can be used as part of compound workup.
  • the "amine” columns or cartridges are used to neutralize or basify acidic reaction mixtures or products. These include NH 2 Aminopropyl SPE-ed SPE Cartridges available from Applied Separations and diethylamino SPE cartridges available from United Chemical Technologies, Inc.
  • the UV detection was at a selected wavelength generally 230nm, 210 nm or 280 nm.
  • Mass spectra were recorded on a mass spectrometer using an alternate-scan positive and negative mode electrospray ionization.
  • Method B (rt - 0.65 min to 0.9 min) Time (min) Flow Rate (ml/min) %A %B 0 20 85 15 1 20 85 15 10 20 45 55 10.5 20 1 99 13 20 85 15 15 20 85 15 Collection was triggered by uv, ms or a combination of the two.
  • the UV detection was at a selected wavelength generally 230nm, 210 nm or 280 nm.
  • Mass spectra were recorded on a mass spectrometer using an alternate-scan positive and negative mode electrospray ionization.
  • Method C (rt - 0.9 min to 1.16 min) Time (min) Flow Rate (ml/min) %A %B 0 20 70 30 1 20 70 30 10 20 15 85 10.5 20 1 99 13 20 70 30 15 20 70 30 Collection was triggered by uv, ms or a combination of the two.
  • the UV detection was at a selected wavelength generally 230nm, 210 nm or 280 nm.
  • Mass spectra were recorded on a mass spectrometer using an alternate-scan positive and negative mode electrospray ionization.
  • Method D (rt - 1.16 min to 1.4 min) Time (min) Flow Rate (ml/min) %A %B 0 20 50 50 1 20 50 50 10 20 1 99 10.5 20 1 99 13 20 50 50 15 20 50 50 Collection was triggered by uv, ms or a combination of the two.
  • the UV detection was at a selected wavelength generally 230nm, 210 nm or 280 nm.
  • Mass spectra were recorded on a mass spectrometer using an alternate-scan positive and negative mode electrospray ionization.
  • Method E (rt - 1.4 to 2.0 min) Time (min) Flow Rate (ml/min) %A %B 0 20 20 80 1 20 20 80 10 20 1 99 10.5 20 1 99 13 20 20 80 15 20 20 80 Collection was triggered by uv, ms or a combination of the two.
  • the UV detection was at a selected wavelength generally 230nm, 210 nm or 280 nm.
  • Mass spectra were recorded on a mass spectrometer using an alternate-scan positive and negative mode electrospray ionization.
  • Step A Thionyl chloride (159 mL, 2178 mmol) was added drop wise over 60 min to water (450 mL) at 0°C. The solution was allowed to stirred at ambient temperature for 17 h then copper(l) chloride (0.554 g, 5.60 mmol) was added to the mixture at -3 °C and the resulting yellow green solution was stirred for 1 hour at -3 °C.
  • Step B 37% HCI (503 mL, 6129 mmol) was added with vigorous stirring to 2-chloropyridin-3-amine (40 g, 311 mmol) at -5 °C and a solution of sodium nitrite (37.8 g, 548 mmol) in water (82 mL) was added drop wise over 45 min, the temperature of the reaction mixture was maintained at -5 °C and stirred for 10 min.
  • Step C The mixture obtained from step B was added to the solution obtained from step A over 30 min at -3 °C. The reaction mixture was maintained at 0°C for 75 min with vigorous stirring. The solid was filtered and dried to give the title compound (20 g, 92 mmol, 29.5% yield) as brown color solid.
  • the sample in reaction solvent was purified by MDAP (method C) using a high pH ammonium carbonate buffer (pH 10) to give the title compound (3S)-N-(1-amino-1-oxopropan-2-yl)-3-(3-(((R)-4-ethyl-1,1-dioxido-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazepin-2-yl)methyl)-4-methylphenyl)-3-(1-ethyl-4-methyl-1H-benzo[d][1,2,3]triazol-5-yl)propanamide (4.6 mg, 6.53% yield).
  • reaction mixture was diluted with ethyl acetate (500 mL) and the organic phase washed with water (4 X 200 mL), brine, dried over sodium sulfate, filtered and the solvent evaporated under reduced pressure.
  • the crude residue was purified by silica gel chromatography (0-50% ethyl acetate/hexanes) to afford an orange oil ( R )-tert-butyl 2-ethyl-2,3-dihydropyrido[2,3- f ][1,4]oxazepine-4(5 H )-carboxylate (4.84 g, 17.39 mmol, 66.3 % yield).
  • N ,3-dimethyl-2-nitroaniline (47.9 g, 288 mmol) was dissolved in N,N -dimethylformamide (250 mL). The mixture was cooled to 5 °C. N -Bromosuccinimide (51.3 g, 288 mmol) dissolved in 150 mL N,N -dimethylformamide was added dropwise via an addition funnel and was stirred at ambient temperature for 24 hr. The reaction mixture was poured into water (1.5 L) and filtered to afford an orange solid 4-bromo- N ,3-dimethyl-2-nitroaniline (73.5 g, 300 mmol, 104 % yield).
  • the reaction mixture was stirred at 40 °C for 2 hr.
  • the reaction mixture was concentrated, diluted with water (100mL) and then it was washed with diethyl ether (150 mL).
  • the aqueous layer was acidified to pH ⁇ 3 with 1N HCl (20mL) and extracted with ethyl acetate (2x50 mL), and the combined organic layers were concentrated under reduced pressure.
  • the residue was purified by flash chromatography eluting with 0-55% EtOAc/Hexane to afford the title compound. (2.5g, 4.54mmol, 65.7 % yield), LC-MS m / z 551 (M+H) + , 2.37 min (ret. time).
  • Methyl 3-(1-ethyl-4-methyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((4-methoxybenzyl)oxy)methyl)-4-methylphenyl)-2,2-dimethylpropanoate was resolved by Chiral SFC (Column: Chiralpak IG, 5u; Co-solvent: 30%EtOH; Flowrate: 80 g/min; Back pressure: 100 Bar) to give Methyl (S)-3-(1-ethyl-4-methyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((4-methoxybenzyl)oxy)methyl)-4-methylphenyl)-2,2-dimethylpropanoate (chiral SFC ret.
  • the intermediate methyl ester was dissolved in methanol (15.00 mL), and treated with LiOH (22.12 mL, 44.2 mmol). The reaction mixture was heated via microwave at 120 °C for 3 h. The solvent was evaporated. The residue was partitioned between ethyl acetate and 1N HCl. The aqueous layer was extracted with ethyl acetate (3X). The combined organic phases were dried over MgSO 4 and concentrated.
  • N-ethyl-3-fluoro-2-nitroaniline 8.0 g, 43.4 mmol
  • DMF 100mL
  • N-bromosuccinimide 6.19 g, 34.8 mmol
  • the mixture was stirred at 0 °C for 6 h.
  • the mixture was quenched with water (500 mL) and extracted with ethyl acetate (3 ⁇ 400 mL).
  • the combined organic layer was washed with water (2 ⁇ 100 mL), brine (2 ⁇ 100 mL), dried (Na 2 SO 4 ) and concentrated.
  • N1-methylethane-1,2-diamine (0.023 mL, 0.268 mmol) was added.
  • the reaction mixture was stirred at ambient temperature for 1 hr.
  • the reaction mixture was partitioned between ethyl acetate and water.
  • the water layer was extracted with ethyl acetate 2x.
  • the combined organic phase was dried over MgSO 4 and concentrated.

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Claims (8)

  1. Composé qui est:
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(pyridin-3-yl)propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(isothiazol-4-yl)propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(oxazol-2-ylméthyl)propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(oxétan-3-yl)propanamide;
    le (3S)-N-(1,1-dioxydotétrahydrothiophén-3-yl)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)propanamide;
    la (S)-1-(3-amino-1H-pyrazol-1-yl)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)propan-1-one;
    la (S)-1-(5-amino-1H-pyrazol-1-yl)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)propan-1-one;
    le (S)-N-((1H-imidazol-2-yl)méthyl)-3-(3-((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(1-méthyl-1H-pyrazol-5-yl)propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(4-méthylpyridin-3-yl)propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(4-méthoxypyridin-3-yl)propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(5-(trifluorométhyl)pyridin-3-yl)propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(5-méthoxypyridin- 3-yl)propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(6-(trifluorométhyl)pyridin-3-yl)propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(6-méthylpyridin-3-yl)propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-((1-méthyl-1H-imidazol-2-yl)méthyl)propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(1-méthyl-1H-imidazol-2-yl)propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(isoquinoléin-4-yl)propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(pyridin-4-yl)propanamide;
    la (R)-4-benzyl-3-(2R,3S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2-méthylpropanoyl)oxazolidin-2-one;
    le (S)-N-(3-(diméthylamino)-3-oxopropyl)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)propanamide;
    le (3S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(tétrahydrofuran-3-yl)propanamide;
    le (S)-N-(1-amino-2-méthyl-1-oxopropan-2-yl)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(1-méthylazétidin-3-yl)propanamide;
    le (3S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(tétrahydro-2H-pyran-3-yl)propanamide;
    le (3S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-((tétrahydrofuran-3-yl)méthyl)propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(2-hydroxy-2-méthylpropyl)propanamide;
    le (3S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(1-(méthylamino)-1-oxopropan-2-yl)propanamide;
    le (3S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(2-oxopipéridin-3-yl)propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(2-sulfamoyléthyl)propanamide;
    le (S)-N-cyclopropyl-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(2-hydroxyéthyl)propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(3-hydroxypropyl)propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(3-méthoxypropyl)propanamide;
    le (S)-N-(2-amino-2-oxoéthyl)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(2-(méthylamino)éthyl)propanamide;
    le (3S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-((tétrahydrofuran-2-yl)méthyl)propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(2-fluoroéthyl)propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(2-(méthylamino)-2-oxoéthyl)propanamide;
    le (S)-N-(2-éthoxyéthyl)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido-[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)propanamide;
    le (S)-3-(3-((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(2-méthoxyéthyl)propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(2-(isopropylamino)-2-oxoéthyl)propanamide;
    le (3S)-N-(1-amino-1-oxopropan-2-yl)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)propanamide,
    le (S)-N-(3-cyanopropyl)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido-[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)propanamide;
    le (S)-N-(2-acétamidoéthyl)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)propanamide;
    le (R)-3-(1,4-diméthyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-éthyl-2,3-dihydropyrido[2,3-f][1,4]oxazépin-4(5H)-yl)méthyl)-4-méthylphényl)-N-(pyridin-3-yl)propanamide;
    le (S)-3-(1,4-diméthyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-éthyl-2,3-dihydropyrido[2,3-f][1,4]oxazépin-4(5H)-yl)méthyl)-4-méthylphényl)-N-(pyridin-3-yl)propanamide;
    le (R)-3-((1-éthyl-1H-1,2,3-triazol-4-yl)méthoxy)-2,2-diméthyl-3-(4-méthyl-3-(((S)-4-méthyl-1,1-dioxydo-4,5-dihydropyrido[4,3-f][1,2]thiazépin-2(3H)-yl)-méthyl)phényl)-N-(pyridin-3-yl)propanamide;
    le (R)-3-((1-éthyl-1H-1,2,3-triazol-4-yl)méthoxy)-2,2-diméthyl-3-(4-méthyl-3-(((S)-4-méthyl-1,1-dioxydo-4,5-dihydrobenzo[f][1,2]thiazépin-2(3H)-yl)-méthyl)phényl)-N-(pyridin-3-yl)propanamide;
    le (R)-2,2-diméthyl-3-(4-méthyl-3-(((S)-4-méthyl-1,1-dioxydo-4,5-dihydropyrido-[2,3-f][1,2]thiazépin-2(3H)-yl)méthyl)phényl)-3-((1-propyl-1H-1,2,3-triazol-4-yl)méthoxy)-N-(pyridin-3-yl)propanamide ;
    le (R)-2,2-diméthyl-3-(4-méthyl-3-(((S)-4-méthyl-1,1-dioxydo-4,5-dihydrobenzo-[f][1,2]thiazépin-2(3H)-yl)méthyl)phényl)-3-((1-propyl-1H-1,2,3-triazol-4-yl)-méthoxy)-N-(pyridin-3-yl)propanamide;
    le (R)-2,2-diméthyl-3-(4-méthyl-3-(S)-4-méthyl-1,1-dioxydo-8-(trifluorométhyl)-4,5-dihydrobenzo[f][1,2]thiazépin-2(3H)-yl)méthyl)phényl)-3-((1-propyl-1H-1,2,3-triazol-4-yl)méthoxy)-N-(pyridin-3-yl)propénamide;
    le (R)-3-(3-((4,4-diméthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-2,2-diméthyl-3-((1-propyl-1H-1,2,3-triazol-4-yl)méthoxy)-N-(pyridin-3-yl)propénamide;
    le (R)-2,2-diméthyl-3-(4-méthyl-3-(((S)-4-méthyl-1,1-dioxydo-4,5-dihydropyrido-[4,3-f][1,2]thiazépin-2(3H)-yl)méthyl)phényl)-3-((1-propyl-1H-1,2,3-triazol-4-yl)méthoxy)-N-(pyridin-3-yl)propénamide;
    le (R)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-2,2-diméthyl-3-((1-propyl-1H-1,2,3-triazol-4-yl)méthoxy)-N-(pyridin-3-yl)propénamide;
    le (R)-3-(3-(((S)-8-fluoro-4-méthyl-1,1-dioxydo-4,5-dihydrobenzo[f][1,2]-thiazépin-2(3H)-yl)méthyl)-4-méthylphényl)-2,2-diméthyl-3-((1-propyl-1H-1,2,3-triazol-4-yl)méthoxy)-N-(pyridin-3-yl)propénamide;
    le (S)-3-(3-(S)-4-éthyl-1,1-dioxydo-4,5-dihydrobenzo[f][1,2]thiazépin-2(3H)-yl)méthyl)-4-méthylphényl)-3-((1-éthyl-1H-1,2,3-triazol-4-yl)méthoxy)-2,2-diméthyl-N-(pyridin-3-yl)propénamide;
    le (S)-3-((1-éthyl-1H-1,2,3-triazol-4-yl)méthoxy)-2,2-diméthyl-3-(4-méthyl-3-(((S)-4-méthyl-1,1-dioxydo-4,5-dihydropyrido[2,3-f][1,2]thiazépin-2(3H)-yl)-méthyl)phényl)-N-(pyridin-3-yl)propénamide;
    le (S)-3-(1-éthyl-7-méthoxy-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthyl-3-(4-méthyl-3-(((R)-4-méthyl-1,1-dioxydo-4,5-dihydrobenzo[f][1,2]-thiazépin-2(3H)-yl)méthyl)phényl)-N-(pyridin-3-yl)propénamide;
    le (R)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-7-méthoxy-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthyl-N-(pyridin-3-yl)propénamide;
    le 3-(7-méthoxy-1-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(4-méthyl-3-(((S)-4-méthyl-1,1-dioxydo-8-(trifluorométhyl)-4,5-dihydrobenzo[f][1,2]thiazépin-2(3H)-yl)méthyl)phényl)-N-(pyridin-3-yl)propénamide;
    le (S)-3-(7-méthoxy-1-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(4-méthyl-3-(((R)-4-méthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazépin-2-yl)-méthyl)phényl)-N-(pyridin-3-yl)propénamide;
    le (S)-3-(1-éthyl-7-méthoxy-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthyl-3-(4-méthyl-3-(((S)-4-méthyl-1,1-dioxydo-8-(trifluorométhyl)-4,5-dihydrobenzo[f][1,2]thiazépin-2(3H)-yl)méthyl)phényl)-N-(pyridin-3-yl)propénamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-7-méthoxy-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthyl-N-(pyridin-3-yl)propénamide;
    le S)-3-(3-((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-7-méthoxy-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-N-(pyridin-3-yl)propénamide;
    le (S)-3-(1-éthyl-7-méthoxy-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthyl-3-(4-méthyl-3-((S)-4-méthyl-1,1-dioxydo-7-(trifluorométhyl)-4,5-dihydrobenzo[f][1,2]thiazépin-2(3H)-yl)méthyl)phényl)-N-(pyridin-3-yl)propénamide;
    le (S)-3-(3-((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(2H-tétrazol-5-yl)propénamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthylpropanamide;
    le 3-(4-cyano-2-méthylphényl)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-N-(pyridin-3-yl)propénamide;
    le 3-(4-cyano-2-méthylphényl)-3-(4-méthyl-3-((4-méthyl-1,1-dioxydo-8-(trifluorométhyl)-4,5-dihydrobenzo[f][1,2]thiazépin-2(3H)-yl)méthyl)phényl)-N-(pyridin-3-yl)propénamide;
    le (S)-3-(3-(((S)-4-éthyl-1,1-dioxydo-4,5-dihydrobenzo[f][1,2]thiazépin-2(3H)-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthyl-N-(1,2,4-thiadiazol-5-yl)propénamide,
    le (S)-3-(3-(((S)-4-éthyl-1,1-dioxydo-4,5-dihydrobenzo[f][1,2]thiazépin-2(3H)-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthyl-N-(1-phényl-1H-tétrazol-5-yl)propénamide;
    le (S)-3-(3-(((S)-4-éthyl-1,1-dioxydo-4,5-dihydrobenzo[f][1,2]thiazépin-2(3H)-yl)-méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthyl-N-(1-(2-oxopropyl)-1H-tétrazol-5-yl)propénamide;
    le (S)-3-(3-(((S)-4-éthyl-1,1-dioxydo-4,5-dihydrobenzo[f][1,2]thiazépin-2(3H)-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthyl-N-(1-(pyridin-2-yl)-1H-tétrazol-5-yl)propénamide;
    le (S)-3-(3-(((S)-4-éthyl-1,1-dioxydo-4,5-dihydrobenzo[f][1,2]thiazépin-2(3H)-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthyl-N-(1-(thiazol-2-ylméthyl)-1H-tétrazol-5-yl)propénamide;
    l'acide 2-(5-((S)-3-(3-((((S)-4-éthyl-1,1-dioxydo-4,5-dihydrobenzo[f][1,2]-thiazépin-2(3H))-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d]-[1,2,3]triazol-5-yl)-2,2-diméthylpropanamido)-1H-tétrazol-1-yl)acétique;
    le sel de N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]-oxathiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d]-[1,2,3]triazol-5-yl)-2-méthylpropan-2-yl)-1H-tétrazole-5-carboxamide et d'acide trifluoroacétique;
    le N-((S)-1-(3-(((S)-4-éthyl-1,1-dioxydo-8-(trifluorométhyl)-4,5-dihydrobenzo[f]-[1,2]thiazépin-2(3H)-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo-[d][1,2,3]triazol-5-yl)-2-méthylpropan-2-yl)-2-(1H-tétrazol-5-yl)acétamide;
    le (S)-3-(1,4-diméthyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-éthyl-2,3-dihydropyrido[3,4-f][1,4]oxazépin-4(5H)-yl)méthyl)-4-méthylphényl)-2,2-diméthyl-N-(2-(méthylamino)éthyl)propénamide;
    le (S)-3-(3-(((S)-4-éthyl-1,1-dioxydo-4,5-dihydrobenzo[f][1,2]thiazépin-2(3H)-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-fluoro-1H-benzo[d][1,2,3]triazol-5-yl)-N-(pyridin-3-yl)propénamide;
    le (S)-3-(3-(((S)-4-éthyl-1,1-dioxydo-4,5-dihydrobenzo[f][1,2]thiazépin-2(3H)-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-fluoro-1H-benzo[d][1,2,3]triazol-5-yl)-N-(2-(méthylamino)éthyl)propénamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-2,2-diméthyl-5-(1-propyl-1H-1,2,3-triazol-4-yl)-N-(pyridin-3-yl)pentanamide;
    le (R)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-2,2-diméthyl-5-(1-propyl-1H-1,2,3-triazol-4-yl)-N-(pyridin-3-yl)pentanamide;
    le (S)-3-(4-chloro-3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]-oxathiazépin-2-yl)méthyl)phényl)-3-(1,4-diméthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthyl-N-(pyridin-3-yl)propénamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-2,2-diméthyl-3-(4-méthyl-1-propyl-1H-benzo[d][1,2,3]triazol-5-yl)-N-(pyridin-3-yl)propénamide,
    le (S)-N-(2-chloropyrimidin-5-yl)-3-(3-((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthylpropanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthylpropanamide;
    le (S)-3-(3-(((S)-4-éthyl-1,1-dioxydo-8-(trifluorométhyl)-4,5-dihydrobenzo[f]-[1,2]thiazépin-2(3H)-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthylpropanamide,
    le (S)-3-(4-chloro-3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]-oxathiazépin-2-yl)méthyl)phényl)-3-(1,4-diméthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthylpropanamide;
    le (R)-3-(3-(((S)-4-éthyl-1,1-dioxydo-8-(trifluorométhyl)-4,5-dihydrobenzo[f]-[1,2]thiazépin-2(3H)-yl)méthyl)-4-méthylphényl)-3-((1-éthyl-1H-1,2,3-triazol-4-yl)méthoxy)-2,2-diméthylpropanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthyl-N-(pyrimidin-5-yl)propénamide;
    le (S)-3-(3-(((S)-4-éthyl-1,1-dioxydo-8-(trifluorométhyl)-4,5-dihydrobenzo[f]-[1,2]thiazépin-2(3H)-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthyl-N-(pyrimidin-5-yl)propénamide,
    le (S)-3-(3-(((S)-4-éthyl-1,1-dioxydo-4,5-dihydrobenzo[f][1,2]thiazépin-2(3H)-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthyl-N-(pyrimidin-5-yl)propénamide;
    le (S)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthyl-3-(4-méthyl-3-(((S)-4-méthyl-1,1-dioxydo-7-(trifluorométhyl)-4,5-dihydrobenzo[f]-[1,2]thiazépin-2(3H)-yl)méthyl)phényl)-N-(pyrimidin-5-yl)propénamide,
    le (S)-3-(3-(((S)-4-éthyl-1,1-dioxydo-4,5-dihydropyrido[2,3-f][1,2]thiazépin-2(3H)-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthyl-N-(pyrimidin-5-yl)propénamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[4,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthyl-N-(pyrimidin-5-yl)propénamide;
    le (S)-3-(3-(((R)-7-bromo-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]-oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d]-[1,2,3]triazol-5-yl)-2,2-diméthyl-N-(pyrimidin-5-yl)propénamide;
    le (S)-3-(3-(((R)-8-bromo-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]-oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d]-[1,2,3]triazol-5-yl)-2,2-diméthyl-N-(pyrimidin-5-yl)propénamide;
    la 1-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d]-[1,2,3]triazol-5-yl)-2-méthylpropan-2-yl)urée,
    le (3S)-3-(1,4-diméthyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-éthyl-2,3-dihydropyrido[3,4-f][1,4]oxazépin-4(5H)-yl)méthyl)-4-méthylphényl)-2,2-diméthyl-N-(tétrahydrofuran-3-yl)propénamide;
    le (3S)-3-(1,4-diméthyl-1H-benzo[d][1,2,3]triazol-5-yl)-N-(1,1-dioxydotétrahydrothiophén-3-yl)-3-(3-(((R)-2-éthyl-2,3-dihydropyrido[3,4-f][1,4]oxazépin-4(5H)-yl)méthyl)-4-méthylphényl)-2,2-diméthylpropanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthyl-N-(2-(méthylamino)éthyl)propénamide;
    le (S)-3-(3-(((S)-4-éthyl-1,1-dioxydo-4,5-dihydropyrido[2,3-f][1,2]thiazépin-2(3H)-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(pyridin-3-yl)propénamide;
    le (S)-N-((1H-imidazol-2-yl)méthyl)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthylpropanamide;
    le (S)-3-(3-(((S)-4-éthyl-1,1-dioxydo-4,5-dihydropyrido[2,3-f][1,2]thiazépin-2(3H)-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(pyrimidin-5-yl)propénamide;
    le (3S)-N-(1,1-dioxydotétrahydrothiophén-3-yl)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthylpropanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d]-[1,2,3]triazol-5-yl)-N-(pyridazin-4-yl)propénamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(pyrimidin-4-yl)propénamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(pyrimidin-5-yl)propénamide;
    le (S)-3-(4-chloro-3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b]-[1,4,5]oxathiazépin-2-yl)méthyl)phényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(pyridin-3-yl)propénamide;
    le (S)-3-(1,4-diméthyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-éthyl-2,3-dihydropyrido[3,4-f][1,4]oxazépin-4(5H)-yl)méthyl)-4-méthylphényl)-2,2-diméthyl-N-(pyridin-3-yl)propénamide;
    le (S)-3-(1,4-diméthyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-éthyl-2,3-dihydropyrido[3,4-f][1,4]oxazépin-4(5H)-yl)méthyl)-4-méthylphényl)-2,2-diméthyl-N-(pyridin-4-yl)propénamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d]-[1,2,3]triazol-5-yl)-2,2-diméthyl-N-((S)-tétrahydrofuran-3-yl)propénamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthyl-N-(R)-tétrahydrofuran-3-yl)propénamide;
    le (S)-3-(3-((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthyl-N-(2-(méthylthio)pyrimidin-5-yl)propénamide;
    le (R)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxa-thiazepin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthyl-N-(pyridin-3-yl)propénamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthyl-N-(pyrimidin-5-yl)propénamide;
    le (S)-3-(3-((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(pyrazin-2-yl)propénamide;
    le (S)-3-(3-(((S)-4-éthyl-1,1-dioxydo-4,5-dihydropyrido[2,3-f][1,2]thiazépin-2(3H)-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthyl-N-(pyridin-3-yl)propénamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthyl-N-(pyridin-3-yl)propénamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(pyrimidin-2-yl)propénamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(pyridazin-3- yl)propénamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(2-méthoxypyrimidin- 5-yl)propénamide;
    le (S)-N-(2-(2-éthoxyéthoxy)pyrimidin-5-yl)-3-(3-((((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthylpropanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(2-(pipéridin-1-yl)pyrimidin-5-yl)propénamide;
    le S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(2-(méthylamino)pyrimidin-5-yl)propénamide;
    le (S)-N-(2-((1,3-dihydroxypropan-2-yl)amino)pyrimidin-5-yl)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)propénamide;
    le (S)-N-(2-((1,3-dihydroxypropan-2-yl)amino)pyrimidin-5-yl)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H -pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthyl-propanamide;
    le (3S)-N-(2-(2-amino-3-hydroxypropoxy)pyrimidin-5-yl)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthyl-phényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthyl-propanamide;
    le (S)-N-(2-(diméthylamino)pyrimidin-5-yl)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthylpropanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthyl-N-(2-(méthylsulfonyl)pyrimidin-5-yl)propénamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)acétamide;
    le 4-acétamido-N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b]-[1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2-méthylpropan-2-yl)butanamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)tétrahydrofurane-3-carboxamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)tétrahydro-2H-pyrane-3-carboxamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)furane-2-carboxamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)furane-3-carboxamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl) isothiazole-5-carboxamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)-1-méthyl-6-oxo-1,6-dihydropyridine-3-carboxamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)-1-méthyl-2-oxo-1,2-dihydropyridine-3-carboxamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d] [1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)-1-méthyl-2-oxo-1,2-dihydropyridine-4-carboxamide;
    l'acide 3-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)amino)-3-oxopropanoïque;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)-2-(méthylsulfonyl)acétamide;
    le 2-cyano-N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b]-[1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2-méthylpropan-2-yl)acétamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)-2-méthoxypyrimidine-5-carboxamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)pyrimidine-5-carboxamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)-2-(méthylthio)pyrimidine-5-carboxamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)-1H-imidazole-4-carboxamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)thiazole-4-carboxamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)-1H-pyrazole-3-carboxamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)oxazole-4-carboxamide GSK3901456A N62324-100-A1;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)isoxazole-5-carboxamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d]-[1,2,3]triazol-5-yl)-2-méthylpropan-2-yl) isoxazole-3-carboxamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)-5-fluoronicotinamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)-5-(trifluorométhyl)nicotinamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)-6-oxo-1,6-dihydropyridine-3-carboxamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)-2-(méthylsulfonyl)pyrimidine-5-carboxamide;
    le 2-(azétidin-1-yl)-N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2-méthylpropan-2-yl)pyrimidine-5-carboxamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)-2-(pyrrolidin-1-yl)pyrimidine-5-carboxamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)-2-(3-méthoxypropoxy)pyrimidine-5-carboxamide;
    le N-((S)-1-(3-((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)-2-(2-hydroxyéthoxy)pyrimidine-5-carboxamide;
    le 2-(diméthylamino)-N-(S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2-méthylpropan-2-yl)pyrimidine-5-carboxamide;
    le 2-(2-éthoxyéthoxy)-N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2-méthylpropan-2-yl)pyrimidine-5-carboxamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)-2-morpholinopyrimidine-5-carboxamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)-2-(4-méthylpipérazin-1-yl)pyrimidine-5-carboxamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)nicotinamide;
    le N-((S)-1-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-1-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2-méthylpropan-2-yl)-N-méthylpyrimidine-5-carboxamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(pyridin-2-yl)propénamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-méthyl-N-(pyridin-3-yl)propénamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-phénylpropanamide;
    le (S)-N-cyclopentyl-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(6-méthoxypyridin-3-yl)propanamide;
    le (S)-3-(3-((2-(cycloheptylméthyl)-1H-imidazol-1-yl)méthyl)-4-méthylphényl)-3-(1,4-diméthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthyl-N-(pyridin-3-yl)-propanamide;
    le (S)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(4-méthyl-3-(((S)-4-méthyl-1,1-dioxydo-8-(trifluorométhyl)-4,5-dihydrobenzo[f][1,2]thiazépin-2(3H)-yl)méthyl)phényl)-N-(pyridin-3-yl)propanamide;
    le (S)-3-(4-chloro-3-((2-((4-éthylpipéridin-1-yl)méthyl)-1H-imidazol-1-yl)-méthyl)phényl)-3-(1,4-diméthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthyl-N-(pyridin-3-yl)propanamide;
    le ((2R,3S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]-oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d]-[1,2,3]triazol-5-yl)-2-méthyl-N-(pyridin-3-yl)propanamide;
    le (2R,3S)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2-méthyl-3 -(4-méthyl-3-(((S)-4-méthyl-1,1-dioxydo-7 -(trifluorométhyl)-4,5-dihydrobenzo[f]-[1,2]thiazépin-2(3H)-yl)méthyl)phényl)-N-(pyridin-3-yl)propanamide;
    le (S)-3-(1-éthyl-4-méthyl-1H-benzo[d[1,2,3]triazol-5-yl)-3-(3-(((S)-8-fluoro-4-méthyl-1,1-dioxydo-4,5-dihydrobenzo[f][1,2]thiazépin-2(3H)-yl)méthyl)-4-méthylphényl)-N-(pyridin-3-yl)propanamide ;
    le (2R,3S)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2-méthyl-3 -(4-méthyl-3-(((S)-4-méthyl-1,1-dioxydo-8-(trifluorométhyl)-4,5-dihydrobenzo[f]-[1,2]thiazépin-2(3H)-yl)méthyl)phényl)-N-(pyridin-3-yl)propanamide;
    le (2R,3S)-3-(3-(((S)-4-éthyl-1,1-dioxydo-8-(trifluorométhyl)-4,5-dihydrobenzo-[f][1,2]thiazépin-2(3H)-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2-méthyl-N-(pyridin-3-yl)propanamide;
    le (S)-3-(1-éthyl-7-méthoxy-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(4-méthyl-3-(((S)-4-méthyl-1,1-dioxydo-8-(trifluorométhyl)-4,5-dihydrobenzo[f]-[1,2]thiazépin-2(3H)-yl)méthyl)phényl)-N-(pyridin-3-yl)propanamide;
    le (2R,3S)-3-(3-(((R)-2-éthyl-2,3-dihydropyrido[2,3-f][1,4]oxazépin-4(5H)-yl)-méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2-méthylpropanamide;
    le (S)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((S)-4-éthyl-9-(trifluorométhyl)-4,5-dihydro-1H-benzo[c]azépin-2(3H)-yl)méthyl)-4-méthyl-phényl)-2,2-diméthylpropanamide;
    le (S)-3-(3-(((R)-2-éthyl-2,3-dihydropyrido[2,3-f][1,4]oxazépin-4(5H)-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthylpropanamide;
    le (R)-3-(4-chloro-3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]-oxathiazépin-2-yl)méthyl)phényl)-5-(1-cyclobutyl-1H-1,2,3-triazol-4-yl)-2,2-diméthylpentanamide;
    le (S)-N-(2-(((tert-butyldiméthylsilyl)oxy)méthyl)pyrimidin-5-yl)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthylpropanamide;
    le (S)-N-(2-(2-((tert-butyldiméthylsilyl)oxy)propan-2-yl)pyrimidin-5-yl)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthylpropanamide;
    le (5-((S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthylpropanamido)pyrimidin-2-yl)méthyl)carbamate de tert-butyle;
    le 5-((S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthylpropanamido)-N,N-diméthylpyrimidine-2-carboxamide;
    le 2-(5-((S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthylpropanamido)pyrimidin-2-yl)oxy)acétate de méthyle;
    le (2-((5-((S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthylpropanamido)pyrimidin-2-yl)oxy)éthyl)carbamate de tert-butyle;
    le (S)-N-(2-(2-(tert-butoxy)éthoxy)pyrimidin-5-yl)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthyl-phényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthyl-propanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(2-(2-méthoxyéthoxy)pyrimidin-5-yl)-2,2-diméthylpropanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(2-(hydroxyméthyl)pyrimidin-5-yl)-2,2-diméthylpropanamide;
    l'acide 5-((S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthylpropanamido)pyrimidine-2-carboxylique;
    le (S)-N-(2-(aminométhyl)pyrimidin-5-yl)-3-(3-((((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthylpropanamide;
    l'acide 2-((5-((S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]-oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d]-[1,2,3]triazol-5-yl)-2,2-diméthylpropanamido)pyrimidin-2-yl)oxy)acétique;
    le (S)-N-(2-(2-aminoéthoxy)pyrimidin-5-yl)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthylpropanamide;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-N-(2-(2-hydroxyéthoxy)pyrimidin-5-yl)-2,2-diméthylpropanamide;
    le 2-((S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthylpropanamido)acétate;
    l'acide 3-((S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthylpropanamido)propanoïque;
    l'acide 2-((S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthylpropanamido)succinique;
    l'acide 3-((S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthylpropanamido)pentanedioïque;
    l'acide 3-((S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthylpropanamido)-3-(pyridin-4-yl)propanoïque;
    l'acide 2-((S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthylpropanamido)propanoïque ;
    le (S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthyl-N-(3,3,3-trifluoropropyl)propénamide;
    l'acide 2-((S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxa-thiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]-triazol-5-yl)-2,2-diméthylpropanamido)-2-méthylpropanoïque;
    le (S)-N-(2-amino-2-oxoéthyl)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthylpropanamide,
    l'acide (S)-2-((S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]-oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d]-[1,2,3]triazol-5-yl)-2,2-diméthylpropanamido)pentanedioïque;
    l'acide (R)-2-((S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b]-[1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo-[d][1,2,3]triazol-5-yl)-2,2-diméthylpropanamido)pentanedioïque;
    l'acide (S)-4-amino-2-((S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo-[b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthylpropanamido)-4-oxobutanoïque;
    l'acide (R)-4-amino-2-(S)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo-[b][1,4,5]|oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthylpropanamido)-4-oxobutanoïque; et
    l'acide 3-((S)-N-(carboxyméthyl)-3-(3-(((R)-4-éthyl-1,1-dioxydo-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazépin-2-yl)méthyl)-4-méthylphényl)-3-(1-éthyl-4-méthyl-1H-benzo[d][1,2,3]triazol-5-yl)-2,2-diméthylpropanamido)propanoïque;
    ou sel pharmaceutiquement acceptable de celui-ci.
  2. Composition pharmaceutique comprenant un composé selon la revendication 1, ou un sel pharmaceutiquement acceptable de celui-ci, et un excipient pharmaceutiquement acceptable.
  3. Composé selon la revendication 1, ou sel pharmaceutiquement acceptable de celui-ci, destiné à être utilisé dans le traitement d'un trouble respiratoire ou non respiratoire, incluant la BPCO, l'asthme, ALI, SDRA, la fibrose, l'asthme chronique, l'asthme aigu, une maladie pulmonaire secondaire à des expositions environnementales, l'infection pulmonaire aiguë, l'infection pulmonaire chronique, la maladie antitrypsine al, la fibrose kystique, les maladies auto-immunes, la néphropathie diabétique, une maladie rénale chronique, une lésion rénale aiguë induite par une septicémie, une lésion rénale aiguë (LRA), une maladie rénale ou un dysfonctionnement rénal observé lors d'une transplantation rénale, l'hypertension artérielle pulmonaire, l'athérosclérose, l'hypertension, l'insuffisance cardiaque, le syndrome coronarien aigu, l'infarctus du myocarde, la réparation du myocarde, le remodelage cardiaque, les arythmies cardiaques, l'insuffisance cardiaque avec fraction d'éjection préservée, l'insuffisance cardiaque avec fraction d'éjection réduite, la cardiomyopathie diabétique, la maladie de Parkinson (MP), la maladie d'Alzheimer (MA), l'ataxie de Friedreich (AF), la sclérose latérale amyotrophique (SLA), la sclérose en plaques (SEP), la maladie inflammatoire de l'intestin, le cancer du côlon, la DMLA néovasculaire (sèche) et la DMLA néovasculaire (humide), une lésion oculaire, la dystrophie endothéliale cornéenne de Fuchs (DECF), l'uvéite ou d'autres affections oculaires inflammatoires, la stéatohépatite non-alcoolique (SHNA), une maladie hépatique induite par une toxine (par exemple une maladie hépatique induite par l'acétaminophène), l'hépatite virale, la cirrhose, le psoriasis, la dermatite/effets topique des rayonnements, l'immunosuppression due à une exposition à des rayonnements, la pré-éclampsie et la maladie de haute altitude.
  4. Composé selon la revendication 1, ou sel pharmaceutiquement acceptable de celui-ci, destiné à être utilisé dans le traitement de la BPCO.
  5. Composé selon la revendication 1, ou sel pharmaceutiquement acceptable de celui-ci, destiné à être utilisé dans le traitement de l'insuffisance cardiaque.
  6. Composé ou sel pharmaceutiquement acceptable de celui-ci, destiné à être utilisé selon les revendications 3 à 5, où le composé est administré par voie orale.
  7. Composé ou sel pharmaceutiquement acceptable de celui-ci, destiné à être utilisé selon les revendications 3 à 5, où le composé est administré par voie intraveineuse.
  8. Composé ou sel pharmaceutiquement acceptable de celui-ci, destiné à être utilisé selon les revendications 3 à 5, où le composé est administré par inhalation.
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US11078216B2 (en) 2021-08-03
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