EP3554434B1 - Beleuchtete chirurgische sonde mit variabler beleuchtung der numerischen apertur - Google Patents

Beleuchtete chirurgische sonde mit variabler beleuchtung der numerischen apertur Download PDF

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Publication number
EP3554434B1
EP3554434B1 EP17811714.9A EP17811714A EP3554434B1 EP 3554434 B1 EP3554434 B1 EP 3554434B1 EP 17811714 A EP17811714 A EP 17811714A EP 3554434 B1 EP3554434 B1 EP 3554434B1
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European Patent Office
Prior art keywords
numerical aperture
probe
illumination light
optical fiber
light
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EP17811714.9A
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English (en)
French (fr)
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EP3554434A1 (de
Inventor
Alireza Mirsepassi
Michael J. Papac
Kambiz PARTO
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Alcon Inc
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Alcon Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F9/009—Auxiliary devices making contact with the eyeball and coupling in laser light, e.g. goniolenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/00736—Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/30—Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
    • A61B2090/306—Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure using optical fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/0008—Apparatus for testing the eyes; Instruments for examining the eyes provided with illuminating means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/13—Ophthalmic microscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00861—Methods or devices for eye surgery using laser adapted for treatment at a particular location
    • A61F2009/00874—Vitreous
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F9/00825—Methods or devices for eye surgery using laser for photodisruption
    • A61F9/0084—Laser features or special beam parameters therefor

Definitions

  • a surgeon may typically use a surgical apparatus comprising a vitreoretinal system with posterior segment and anterior segment procedure capabilities.
  • the surgical apparatus may also include various probes, an ophthalmic microscope, an illuminator, a console with processors and a touch panel screen, and an embedded laser that's controlled from a system screen on the touch panel.
  • Vitrectomy probes may be used during vitreoretinal surgery to remove ocular tissues, such as vitreous humor and membranes covering the retina. These probes have a port for drawing in and dissecting tissues.
  • a laser probe may have a continuous laser beam or a pulsed laser beam.
  • Some probe designs may include illumination that provides a narrow beam of light over the probe of sufficient intensity to facilitate vitreous visualization.
  • the light beam can be too narrow and/or intense for certain tasks other than vitreous visualization.
  • the narrow beam may be too intense for general illumination in the vitreous cavity or when the vitrectomy probe has to be operated very close to the retina for bi-manual surgery or other applications.
  • Document US 2014 121 469 discloses a surgical instrument comprising a set of optical fibers encased within a probe needle.
  • the aperture of the illumination beam emitted by the fibers is variable to adapt lighting conditions during vitreo-retinal procedures.
  • the exemplary embodiments provide methods and systems for a surgical probe system comprising a surgical probe having a probe needle, an optical fiber incorporated onto the probe needle, wherein a proximal end of the optical fiber is connected to a light source and a distal end of the optical fiber projects illumination light from the light source over tip of the probe needle; and an adjustment mechanism that varies the illumination light between a first beam having a first numerical aperture that facilitates vitreous visualization and a second beam having a second numerical aperture that facilitates background illumination, wherein the second numerical aperture is larger than the first numerical aperture.
  • an illuminated surgical probe having a variable illumination numerical aperture is provided.
  • FIGS. 1A and 1B are diagrams illustrating embodiments of a surgical apparatus comprising an illuminated surgical probe having a variable numerical aperture, where like components have like reference numerals.
  • FIG. 1A shows an embodiment where the surgical probe system 2a includes a hand-held surgical probe 10a coupled to console 4.
  • the surgical probe system 2a may represent a vitreoretinal system with posterior segment and anterior segment procedure capabilities.
  • the console 4 of the surgical probe system 2a may include a light source (e.g., an illuminator) 5, a processor (e.g., CPU (Central Processing Unit)) 7, and a touch panel 6 that may be used to control the console 4a and the surgical probe 10a.
  • a light source e.g., an illuminator
  • processor e.g., CPU (Central Processing Unit)
  • the surgical probe 10a may comprise a vitrectomy probe that includes a probe needle 12a connected to a handle 14a, which in turn, is connected to fluidics and drive cables 16a and a signal and power line 18a, both coupled to the console 4a.
  • FIG. 1B shows an embodiment of a surgical probe system 2b where the surgical probe 10b comprises a laser probe, and similarly includes a probe needle 12b connected to a handle 14b, and the handle 14b connected to a laser fiber 16b and a signal and power line 18b.
  • the surgical probe system 2a and 2b include an optical fiber 13a and 13b incorporated onto the probe needle 12a and 12b of the surgical probe 10a and 10b, respectively.
  • a proximal end of the optical fiber 13 is connected to the light source 5 and a distal end of the optical fiber 13 projects illumination light from the light source 5 over tip of the probe needle 12.
  • the surgical probe system 2 includes an adjustment mechanism 8 that varies the illumination light between a first beam having a first numerical aperture that facilitates vitreous visualization and a second beam having a second numerical aperture that facilitates background illumination, wherein the second numerical aperture is larger than the first numerical aperture.
  • FIGS. 2A and 2B are diagrams illustrating first and second beams projected from the optical fiber as controlled by the adjustment mechanism 8.
  • the surgical probe 12 may further include optional fiber protection 22 that covers the optical fiber 13 and surrounds the portion of the probe needle 12 on which the optical fiber 13 lies.
  • the fiber protection 22 may comprise any rigid material that supports and prevents crushing of the optical fiber 13.
  • Example types of materials include stainless steel, glass, and the like.
  • the adjustment mechanism 8 varies the illumination light between a narrow beam 20a and a wide beam 20b by changing a launch angle of the illumination light from the light source 5 into the proximal end of the optical fiber 13.
  • the adjustment mechanism 8 may adjust a launch angle of illumination light from the light source 5 into the proximal end of optical fiber 13 such that the narrow beam 20a of light with adequate intensity is delivered into the vitreous cavity for vitreous visualization.
  • the numerical aperture of the narrow beam has a low numerical value of approximately less than or equal to .3, or more specifically .1 to .3. In one specific application, the numerical aperture of the narrow beam may be .26.
  • the adjustment mechanism 8 may adjust a launch angle of illumination light from the light source 5 into the proximal end of optical fiber 13 such that a wide beam 20b is delivered into the vitreous cavity for general illumination (background illumination or task illumination, e.g., such as for membrane peeling).
  • the numerical aperture of the wide beam has a relatively high numerical value of approximately greater than .4, or more specifically .4 to .7. In one specific application, the numerical aperture of the wide beam may be .56.
  • the adjustment mechanism 8 provides background/situational awareness illumination by varying the numerical aperture of the light output.
  • the light launched into the fiber can be white light, a single wavelength (such as green light centered at 532 nm (nanometers)), RGB (Red Green Blue), or RGB plus additional wavelengths.
  • FIGS. 3A and 3B are diagrams illustrating implementation embodiments of the adjustment mechanism that controls the variable numerical aperture.
  • FIG. 3A shows that in one embodiment, the adjustment mechanism 8 may comprise one or more lenses 30 incorporated in the light source 5 that focus illumination light 32 onto the optical fiber 13.
  • the adjustment mechanism may adjust the variable numerical aperture by moving the lenses relative to each other to adjust the light angle or by switching a light path between two different sets of lenses (each set configured to output the light at a different numerical aperture). Other adjustments of the numerical aperture are also contemplated.
  • FIG. 3B shows that in another embodiment, the adjustment mechanism 8 may comprise one or more optical elements 34 (e.g., lenses) placed in a path of the illumination light 32, prior to reaching the fiber, to disperse the illumination light 32 and change angular content of the illumination light 32.
  • the adjustment mechanism may adjust the variable numerical aperture by moving the optical elements relative to each other to adjust the light angle or by switching a light path between two different sets of optical elements (each set configured to output the light at a different numerical aperture). Other adjustments of the numerical aperture are also contemplated.
  • the processor (CPU) 7 may be configured to control the adjustment mechanism 8 based on commands entered at the console 4 (e.g., through touch screen 6) to which the surgical probe 10 is connected.
  • the processor 7 may control the adjustment mechanism based on a command/signal received from a console to which the surgical probe is connected, a switch 19 on the surgical probe 10, and/or a footswitch.
  • the switch 19 may be located on the handle 14 of the surgical probe 10 and may comprise a two position switch, one position for the narrow beam and a second position for the wide beam.
  • control mechanisms are also contemplated (e.g., instead of a switch, a dial on the surgical probe 10 may be rotated to change the numerical aperture).
  • the numerical aperture may be changed in discrete increments (e.g., wide or narrow) or may be changed over a continuum.
  • the processor 7 may control the adjustment mechanism 8 based on retinal proximity detection signals received from a retinal proximity detection sensor 21 (e.g., see proximity detection sensors 21a and 21b) that detects proximity or distance between the probe needle and a retina during surgery. Retinal proximity detection may be performed by an optical or ultrasonic retinal proximity detection sensor.
  • the processor 7 may switch the numerical aperture to a wide angle when the probe is located relatively close to the retina and to a narrow angle when the probe is located relatively far to the retina (for vitreous illumination).
  • the surgeon may program the relative distances at which the switching occurs.
  • the numerical aperture may be continuously changed (e.g., progressively widened or progressively narrowed) based on the detected distances. For example, as the probe gets further from the retina, the numerical aperture may become progressively narrowed. Further, as the probe gets closer to the retina, the numerical aperture may become progressively wider.
  • Light intensity may also be controlled in a discrete or continuous matter by the processor and adjustment mechanism. For example, as the probe gets closer to the retina, the intensity of the light may be reduced. Further, as the probe gets further from the retina, the intensity of the light may be increased.
  • the type of light may also be adjusted by the processor and adjustment mechanism. For example, at further distances when a narrower numerical aperture is used, a white light may be used.
  • the adjustment mechanism may also filter out some of the frequencies of light introduced into the optical fiber.
  • Other patterns of wider/narrow numerical aperture, light intensity used at various distances, and types of light at used various distances may be programmed by the surgeon (or preprogrammed) as needed.
  • the retinal proximity detection sensor 21 may be located at any position of the surgical probe 10. Although in FIGS. 1A and 1B , the proximity sensor 21 is shown located within the handle 14 of the surgical probe 10, the proximity detection sensor 21 may be alternatively located along the probe needle 12 parallel to the optical fiber 13.
  • the processor 7 is located in the console 4.
  • a processor used to control the adjustment mechanism 8 may be located within the surgical probe 10.
  • a memory may be coupled to both the processor and the proximity sensor 21 or the switch 19 in the surgical probe 10.
  • the memory 22 may be used to store the software instructions, as well as the data collected by the proximity sensor 21 and the data computed by the processor.
  • FIG. 4 illustrates a method of providing an illuminated surgical probe having variable illumination numerical aperture.
  • the elements of FIG. 4 are meant to be illustrative. The elements may be performed in a different order and other elements may be added.
  • an optical fiber may be incorporated onto the probe needle, wherein a proximal end of the optical fiber is connected to a light source and a distal end of the optical fiber projects illumination light from the light source over a tip of the probe needle.
  • the illumination light may be varied, by an adjustment mechanism, between a first beam having a first numerical aperture that facilitates vitreous visualization and a second beam having a second numerical aperture that facilitates background illumination, wherein the second numerical aperture is larger than the first numerical aperture.
  • the processors 7 may be configured to execute the instructions stored in a memory to cause and control the process as described in this disclosure.
  • a processor may comprise one or more microprocessors, field-programmable gate arrays (FPGAs), controllers, or any other suitable computing devices or resources, and memory may take the form of volatile or non-volatile memory including, without limitation, magnetic media, optical media, random access memory (RAM), read-only memory (ROM), removable media, or any other suitable memory component.
  • Memory may store instructions for programs and algorithms that, when executed by a processor, implement the functionality described herein with respect to any such processor, memory, or component that includes processing functionality.

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  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Laser Surgery Devices (AREA)

Claims (11)

  1. Chirurgisches Sondensystem (2, 2a, 2b), umfassend:
    eine chirurgische Sonde (10, 10a, 10b) mit einer Sondennadel (12, 12a, 12b);
    eine Lichtleiterfaser (13, 13a, 13b), die auf der Sondennadel (12, 12a, 12b) eingearbeitet ist, wobei ein proximales Ende der Lichtleiterfaser mit einer Lichtquelle (5) verbunden ist und ein distales Ende der Lichtleiterfaser bei Gebrauch Beleuchtungslicht (32) von der Lichtquelle über eine Spitze der Sondennadel projiziert; und
    einen Anpassungsmechanismus (8), der eingerichtet ist, um das Beleuchtungslicht (32) zwischen einem ersten Strahl (20a) mit einer ersten numerischen Apertur zur Glaskörpervisualisierung und einem zweiten Strahl (20b) mit einer zweiten numerischen Apertur zur Hintergrundbeleuchtung zu variieren, wobei die zweite numerische Apertur größer als die erste numerische Apertur ist;
    dadurch gekennzeichnet, dass:
    der Anpassungsmechanismus (8) die numerische Apertur durch Bewegen von Linsen (30), die in die Lichtquelle (5) eingearbeitet sind, und Fokussieren des Beleuchtungslichts (32) auf die Lichtleiterfaser relativ zueinander, um einen Lichtwinkel des Beleuchtungslichts (32) anzupassen oder Schalten eines Lichtpfads des Beleuchtungslichts zwischen zwei unterschiedlichen Sätzen von Linsen anpasst, und dass die chirurgische Sonde (10, 10a, 10b) des Weiteren umfasst:
    einen Retinanähedetektierungssensor (21a, 21b), der eingerichtet ist, um Nähe oder Distanz zwischen der Sondennnadel und der Retina während der Operation zu detektieren, und
    einen Prozessor (7), der ausgestaltet ist, um den Anpassungsmechanismus (8) basierend auf Retinanähedetektierungssignalen zu steuern, die von dem Retinanähedetektierungssensor (21, 21a, 21b) empfangen wurden, so dass der Prozessor (7) auf die erste numerische Apertur schaltet, wenn die Sondennadel (12, 12a, 12b) sich weiter als eine erste vorprogrammierte ferne Distanz von der Retina befindet, und auf die zweite numerische Apertur schaltet, wenn sich die Sondennadel (12, 12a, 12b) weniger als eine vorprogrammierte nahe Distanz von der Retina befindet.
  2. Chirurgisches Sondensystem nach Anspruch 1, wobei der Anpassungsmechanismus (8) das Beleuchtungslicht (32) zwischen den ersten und zweiten Strahlen variiert, indem ein Einkopplungswinkel des Beleuchtungslichts von der Lichtquelle (5) in das proximale Ende der Lichtleiterfaser (13, 13a, 13b) hinein verändert wird.
  3. Chirurgisches Sondensystem nach Anspruch 2, wobei die erste numerische Apertur einen numerischen Wert von ungefähr kleiner als oder gleich 0.3 hat.
  4. Chirurgisches Sondensystem nach Anspruch 2, wobei die zweite numerische Apertur einen numerischen Wert von ungefähr größer als 0.4 hat.
  5. Chirurgisches Sondensystem nach Anspruch 2, wobei der Anpassungsmechanismus (8) ein oder mehrere optische Elemente (34) umfasst, die in einem Pfad des Beleuchtungslichts (32) platziert sind, bevor die Lichtleiterfaser (13, 13a, 13b) erreicht wird, um das Beleuchtungslicht zu dispergieren und den Winkelgehalt des Beleuchtungslichts zu ändern.
  6. Chirurgisches Sondensystem nach Anspruch 2, wobei der Prozessor (7) des Weiteren ausgestaltet ist, um den Anpassungsmechanismus (8) basierend auf Befehlen zu steuern, die an einer oder allen von einer Konsole (4, 4a), mit der die chirurgische Sonde (10, 10a, 10b) verbunden ist, einem Schalter (19) auf der chirurgischen Sonde und einem Fußschalter eingegeben werden.
  7. Chirurgisches Sondensystem nach Anspruch 1, wobei die chirurgische Sonde (10, 10a, 10b) eine Vitrektomiesonde oder eine Lasersonde umfasst.
  8. Computerimplementiertes Verfahren zum Bereitstellen einer beleuchteten chirurgischen Sonde (10, 10a, 10b) mit variabler numerischer Apertur der Beleuchtung, wobei die chirurgische Sonde eine Sondennadel (12, 12a, 12b) umfasst, wobei das Verfahren umfasst:
    Einarbeiten einer Lichtleiterfaser (13, 13a, 13b) auf die Sondennadel (12, 12a, 12b), wobei ein proximales Ende der Lichtleiterfaser mit einer Lichtquelle (5) verbunden ist und ein distales Ende der Lichtleiterfaser Beleuchtungslicht (32) von der Lichtquelle über eine Spitze der Sondennadel projiziert;
    Detektieren von Nähe der Sondennadel (12, 12a, 12b) an der Retina unter Verwendung eines Retinanähedetektierungssensors;
    Variieren des Beleuchtungslichts (32) zwischen einem ersten Strahl mit einer ersten numerischen Apertur zur Glaskörpervisualisierung und einem zweiten Strahl mit einer zweiten numerischen Apertur zur Hintergrundbeleuchtung mittels eines Anpassungsmechanismus (8), wobei die zweite numerische Apertur größer als die erste numerische Apertur ist;
    wobei der Anpassungsmechanismus (8) die numerische Apertur durch Bewegen von Linsen (30), die in die Lichtquelle (5) eingearbeitet sind, und Fokussieren des Beleuchtungslichts (32) auf die Lichtleiterfaser relativ zueinander, um einen Lichtwinkel des Beleuchtungslichts (32) anzupassen, oder Schalten eines Lichtpfads des Beleuchtungslichts zwischen zwei unterschiedlichen Sätzen von Linsen anpasst;
    wobei Variieren des Beleuchtungslichts Schalten auf die erste numerische Apertur, wenn basierend auf Retinanähedetektierungssignalen von dem Retinanähesensor die Sondennadel (12, 12a, 12b) sich weiter als eine erste vorprogrammierte ferne Distanz von der Retina befindet, und Schalten auf die zweite numerische Apertur umfasst, wenn sich die Sondennadel (12, 12a, 12b) weniger als eine vorprogrammierte nahe Distanz von der Retina befindet.
  9. Verfahren nach Anspruch 8, wobei der Anpassungsmechanismus (8) das Beleuchtungslicht (32) zwischen den ersten und zweiten Strahlen variiert, indem ein Einkopplungswinkel des Beleuchtungslichts von der Lichtquelle (5) in das proximale Ende der Lichtleiterfaser (13, 13a, 13b) hinein verändert wird.
  10. Verfahren nach Anspruch 9, wobei die erste numerische Apertur einen numerischen Wert von ungefähr kleiner als oder gleich 0.3 hat.
  11. Verfahren nach Anspruch 9, wobei die zweite numerische Apertur einen numerischen Wert von ungefähr größer als 0.4 hat.
EP17811714.9A 2016-12-15 2017-11-15 Beleuchtete chirurgische sonde mit variabler beleuchtung der numerischen apertur Active EP3554434B1 (de)

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US201662434516P 2016-12-15 2016-12-15
PCT/IB2017/057140 WO2018109580A1 (en) 2016-12-15 2017-11-15 Illuminated surgical probe having a variable illumination numerical aperture

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EP3554434B1 true EP3554434B1 (de) 2021-08-11

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EP (1) EP3554434B1 (de)
JP (1) JP6928089B2 (de)
CN (1) CN110072496A (de)
AU (1) AU2017376763A1 (de)
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CN110072496A (zh) 2019-07-30
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JP2020500624A (ja) 2020-01-16
JP6928089B2 (ja) 2021-09-01
US20180168861A1 (en) 2018-06-21
US10758419B2 (en) 2020-09-01
EP3554434A1 (de) 2019-10-23

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