EP3538273B1 - Pipette et procédé permettant d'ajuster un volume de pipetage d'une pipette - Google Patents

Pipette et procédé permettant d'ajuster un volume de pipetage d'une pipette Download PDF

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Publication number
EP3538273B1
EP3538273B1 EP17780305.3A EP17780305A EP3538273B1 EP 3538273 B1 EP3538273 B1 EP 3538273B1 EP 17780305 A EP17780305 A EP 17780305A EP 3538273 B1 EP3538273 B1 EP 3538273B1
Authority
EP
European Patent Office
Prior art keywords
pipette
activation element
volume
activation
pipetted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP17780305.3A
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German (de)
English (en)
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EP3538273A1 (fr
Inventor
Philip DÖBELE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IKA Werke GmbH and Co KG
Original Assignee
IKA Werke GmbH and Co KG
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Filing date
Publication date
Application filed by IKA Werke GmbH and Co KG filed Critical IKA Werke GmbH and Co KG
Priority to EP21157053.6A priority Critical patent/EP3858486A1/fr
Publication of EP3538273A1 publication Critical patent/EP3538273A1/fr
Application granted granted Critical
Publication of EP3538273B1 publication Critical patent/EP3538273B1/fr
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Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • B01L3/0279—Interchangeable or disposable dispensing tips co-operating with positive ejection means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/54—Supports specially adapted for pipettes and burettes
    • B01L9/543—Supports specially adapted for pipettes and burettes for disposable pipette tips, e.g. racks or cassettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/08—Ergonomic or safety aspects of handling devices
    • B01L2200/087—Ergonomic aspects
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids

Definitions

  • the invention relates to a pipette with a pipette button, with a pipette shaft on whose free shaft end a pipette tip can be slipped or attached, and with an ejection mechanism comprising an actuating element for ejecting a pipette tip attached to the free shaft end.
  • Pipettes of the type mentioned are, for example, from the publications WO 2009/118456 A1 , WO 2011/025399 A2 , US 2014/298925 A1 such as US 2016/051978 A1 previously known.
  • the invention further relates to a method for setting a volume to be pipetted of a pipette, in particular a pipette according to the invention.
  • the prior art also provides various concepts for setting a volume of a pipette to be pipetted, which is then also referred to as a volume-variable pipette can be previously known.
  • concepts are already known in which the volume of the pipette is adjusted by means of a volume adjustment element.
  • the volume setting element is arranged on the pipette in such a way that an unintentional adjustment of the preset volume is prevented between two pipetting processes or also during a pipetting process.
  • the volume setting element can be arranged so far away from the pipetting button that an unintentional volume adjustment during pipetting can be avoided if the pipette is operated properly.
  • this can restrict the accessibility of the volume setting element for a user.
  • the object of the invention is to provide a pipette and a method for setting a volume to be pipetted of a pipette of the type mentioned at the beginning, with which the handling of the pipette can be simplified.
  • this object is achieved by a pipette with the means and features of claim 1.
  • a pipette is proposed to achieve this object, in which the actuating element forms a passage for the pipetting button, so that an actuating surface of the actuating element at least partially encloses a longitudinal axis of the pipetting button.
  • a pipette is created which, due to the passage that forms the actuating element for the pipetting button, is designed to be particularly compact, at least in a head region of the pipette. This is because the pipetting button is integrated into the actuating element of the ejection mechanism.
  • the configuration of the pipette according to the invention offers the advantage that the actuating surface of the actuating element for ejecting an attached pipette tip compared to the pipettes known from the prior art is enlarged.
  • the actuation surface of the actuation element it is possible for the actuation surface of the actuation element to enclose the pipetting button in a certain angular range, that is to say for example in an angular range of 90 °, 180 °, 270 ° or even 360 °.
  • the user has an actuation surface arranged at least partially around the pipetting button for actuating the actuation element.
  • the ejection mechanism of the pipette according to the invention can thus be more accessible to a user, even in the case of possibly different postures in which the pipette is held by one user or by different users.
  • a pipette with the means and features of claim 2.
  • a pipette is also proposed to achieve the object defined at the beginning, in which the actuating element is set up to control the volume adjustment mechanism and thus to adjust the volume to be pipetted.
  • the actuating element in addition to the ejection function of an attached pipette tip, the actuating element can also be assigned the function of adjusting the volume to be pipetted.
  • a pipette of the type mentioned is also proposed, in which it is provided that the actuating element forms a passage for the pipetting button, so that an actuating surface of the actuating element at least partially encloses a longitudinal axis of the pipetting button, and that the actuating element for controlling the volume adjustment mechanism and thus for adjustment of the volume to be pipetted is set up.
  • a pipette is provided with an actuating element for actuating the ejection mechanism of the pipette, in which the actuating element is on the one hand enlarged in terms of its actuating surface compared to the pipettes known from the prior art, and in which the actuating element in addition to the function of actuating the
  • the ejection mechanism is also assigned the function of controlling the volume adjustment mechanism.
  • a separate volume adjustment element on the pipette which may interfere with the handling of the pipette, can thus be dispensed with.
  • a particularly convenient adjustment of the volume to be pipetted can be achieved if the actuating element is designed as a rotary knob.
  • the actuating element is designed as a rotary knob that can be rotated about the longitudinal axis of the pipetting button to adjust the volume to be pipetted.
  • the design of the actuating element as a rotary knob can be advantageous.
  • the actuation surface of the actuation element can be oriented transversely or at right angles to the longitudinal axis of the pipetting button. It is possible that the actuating surface of the pipetting button surrounds the longitudinal axis of the pipetting button in a ring shape, in particular in a circular ring shape.
  • the actuation element can thus be designed in such a way that it completely surrounds the longitudinal axis of the pipetting button at least with its actuation surface, so that the longitudinal axis of the pipetting button and also the pipetting button are laterally surrounded on all sides by the actuation surface of the actuation element. In this way, a pipette with an actuator provided for the ejection mechanism, which is accessible from different directions for actuation. In this way, the ejection mechanism can be operated reliably and particularly comfortably, even if the pipette is held in a wide variety of positions.
  • the pipetting button protrudes axially beyond the actuating surface of the actuating element, i.e. protrudes beyond the actuating element, in particular upwards.
  • the actuating element can be moved from an initial position into an actuating position against a restoring force of a restoring element.
  • the return element can be, for example, a return spring.
  • a spiral spring designed as a compression spring can expediently be used as the restoring element.
  • the actuation element can be moved from its initial position into its actuation position by an axial displacement in the direction of the free shaft end of the pipette. The reset then takes place axially in the opposite direction.
  • the ejection mechanism can comprise an ejection element movable relative to the pipette shaft.
  • This ejection element can be displaced into its ejection position relative to the pipette shaft in the direction of the free end of the pipette shaft by actuating the actuating element for ejecting a pipette tip placed on the free shaft end.
  • the ejection element can be displaced in the axial direction in relation to a longitudinal axis of the pipette shaft.
  • the ejection element can be designed as an ejection sleeve or as an ejection sleeve segment which at least partially surrounds the pipette shaft.
  • the pipette can furthermore have a force transmission element which connects the actuating element to the aforementioned ejection element and via which an actuating force generated by actuating the actuation element can be transmitted from the actuation element to the ejection element.
  • a force transmission element can be particularly advantageous when the actuation element is arranged on a head end of the pipette opposite the free shaft end, that is, when a certain distance has to be bridged between the actuation element and the ejection element.
  • the force transmission element can for example comprise a force transmission sleeve and / or at least one force transmission arm.
  • the force transmission element can, however, also have a force transmission ring, which is preferably releasably connectable or connected to the ejection element, on which at least one such force transmission arm or such a force transmission sleeve engages, which is connectable or connected to the actuating element.
  • the ejection element is connected to the actuating element, for example via one or the aforementioned force transmission element, that the ejection element can also be moved from an initial position into a ejection position or ejection position against the restoring force of the restoring element mentioned above. Due to the restoring force of the restoring element, the actuating element, the ejection element and also the force transmission element can be automatically moved back into their starting position.
  • the pipette according to the invention can have a particularly compact shape if a diameter of the actuating element is less than or equal to a diameter of a housing of the pipette.
  • the actuating element can thus be designed in such a way that it does not protrude laterally beyond a housing of the pipette in the position of use. An undesired triggering of the ejection mechanism by unintentional actuation of the actuating element can thus be avoided.
  • the pipette can have a symmetrical structure if the pipetting button is arranged centrally on an upper side or on a head part of, for example, the housing of the pipette already mentioned above.
  • the actuating element can be axially displaceable and non-rotatable relative to a housing of the pipette, for example the already mentioned starting position, for example the already mentioned housing. If the actuating element is rotationally fixed in the starting position relative to the housing of the pipette, an unintentional adjustment of the volume of the volume to be pipetted can be reliably avoided. This is particularly the case when a rotary movement of the actuating element is provided in order to change the volume to be pipetted.
  • the actuating element from one, for example the already mentioned, starting position in a volume adjustment position can be moved. This makes sense in particular when the actuating element is arranged in its initial position on the housing in a rotationally fixed manner, so that in the initial position of the actuating element a volume setting or volume change of the volume to be pipetted is prevented.
  • the actuating element can be axially displaced from the starting position into its volume adjustment position in relation to the longitudinal axis of the pipetting button and also in relation to the longitudinal axis of the actuating element relative to the housing of the pipette.
  • a locking device in particular a toothing, can be provided. This can be effective between the actuating element and a further element of the pipette, at least when the actuating element is in its starting position and / or in its actuating position.
  • the locking of the actuating element to secure the actuating element against rotation in its starting position can be released by moving it into its volume adjustment position, so that it can then be rotated in its volume adjustment position on the housing to adjust the volume to be pipetted. This is particularly the case when the actuating element is also designed as a rotary knob.
  • the volume setting of the volume to be pipetted with the aid of the actuating element can take place particularly safely and precisely if a radial surface, in particular a circumferential surface of the actuating element, has a non-slip structure, in particular knurling, and / or a non-slip coating.
  • the aforementioned object is also achieved by a method of the type mentioned at the beginning for setting a volume to be pipetted of a pipette, in particular a pipette according to the invention, with the means and features of the independent claim directed to such a method.
  • a method for setting a volume of a pipette to be pipetted is proposed, the volume to be pipetted being set by means of an actuating element, coupled to a volume adjustment mechanism of the pipette, of an ejection mechanism of the pipette for ejecting a pipette tip attached to a free shaft end of the pipette.
  • a particularly precise setting of the volume to be pipetted can take place if the volume to be pipetted is set by turning the actuating element, in particular designed as a rotary knob.
  • the actuating element in particular designed as a rotary knob, can be rotated around a longitudinal axis of the pipette, around a longitudinal axis of a pipetting button and / or around a longitudinal axis of the actuating element.
  • a lock for securing the actuating element against rotation in an initial position on the housing of the pipette can be released by a, preferably axial, movement of the actuating element into a volume adjustment position on the housing, so that the actuating element can be rotated to set a volume to be pipetted .
  • the actuating element can be axially displaced, in particular raised, on the housing with respect to a longitudinal axis of the pipetting button, the actuating element and / or the pipette.
  • the Figures 1 to 5 show a pipette, designated as a whole by 1, which has a pipetting button 3 on a head end 2.
  • the pipette 1 also has a pipette shaft 4 facing away from the head end 2, on the free shaft end 5 of which a pipette tip can be attached and is attached when the pipette 1 is in the position of use.
  • the pipette 1 is equipped with an ejection mechanism 6 which comprises an actuation element 7 which is also provided in the area of the head end 2 on a housing 8 of the pipette 1.
  • the ejection mechanism 6 is triggered and a pipette tip attached to the free shaft end 5 is ejected from the pipette shaft 4.
  • the actuating element 7 forms a passage 9 for the pipetting button 3, so that an actuating surface 10 of the actuating element 7 at least partially encloses or surrounds a longitudinal axis L of the pipetting button 3.
  • a handle 8a which can be detached from the housing 8 of the pipette 1 and which is designed as a hook at its upper end.
  • the pipette 1 shown also has a volume adjustment mechanism 11 which is set up to adjust a volume to be pipetted with the pipette 1.
  • the pipette 1 is thus a volume-variable pipette which can also be operated mechanically and manually.
  • the pipette tip attached to the shaft end 5 is also used to control the volume adjustment mechanism 11 and thus to adjust the volume to be pipetted.
  • the actuating element 7 is designed as a rotary knob that can be rotated about the longitudinal axis L of the pipetting button 3. More precisely, the actuating element 7 is designed as a push-and-turn button, pressing the actuating element 7 activates and triggers the ejection mechanism 6 and rotating the actuating element 7 triggers a volume adjustment of the volume to be pipetted.
  • the actuation surface 10 of the actuation element 7 is aligned transversely and in sections even at right angles to the longitudinal axis L of the pipetting button 3.
  • the actuating surface 10 surrounds the longitudinal axis L of the pipetting button 3 in a ring shape, in the embodiment shown in the figures even in a ring shape.
  • the passage 9, which forms the actuating element 7 for the pipetting button 3, is thus delimited by the annular actuating surface 10. In the use position of both the pipetting button 3 and the actuating element 7, the pipetting button 3 is positioned in the passage 9 of the actuating element 7.
  • the pipetting button 3 is arranged on the housing 8 of the pipette 1 in the area of the head end 2 of the pipette 1 in such a way that it axially protrudes beyond the actuation surface 10 of the actuation element 7 in relation to its longitudinal axis L.
  • the actuating element 7 is against a restoring force of a restoring element 12, which is designed here as a restoring spring, from its starting position (cf. Fig. 1 and 2 as well as 4 and 5) can be moved into its actuating position. In this actuation position, the actuation element 7 can be moved axially in the direction of the free shaft end 5 of the pipette shaft 4 of the pipette 1 be moved when a certain actuation pressure is exerted on the actuation surface 10 and the resistance of the restoring element 12 is overcome.
  • a restoring element 12 which is designed here as a restoring spring
  • the ejection mechanism 6 comprises an ejection element 13 which is movable relative to the pipette shaft 4.
  • the figures show that this ejection element 13 is designed as an ejection sleeve and accommodates the pipette shaft 4.
  • the sleeve-shaped ejection element 13 is moved into its ejection position axially to the longitudinal axis L of the pipette button 3 and also to the longitudinal center axis of the pipette shaft 4 by actuating the actuating element 7 to eject a pipette tip placed on the free shaft end 5 relative to the pipette shaft 4 in the direction of the free end 5 of the pipette shaft 4 postponed.
  • an end face 14 of the sleeve-shaped ejection element 13 strikes a pipette tip placed on the free shaft end 5 and can then slide it off and detach it from the free shaft end 5.
  • the pipette 1 also has a force transmission element 15 which can be easily seen in the sectional views.
  • this force transmission element 15 can comprise a force transmission sleeve or, as provided in the embodiment of the pipette 1 shown in the figures, a certain number of individual force transmission arms 17 connected to one another via a force transmission ring 16.
  • the force transmission element 15 connects the actuation element 7 with the ejection element 13 and enables a control force generated by actuation of the actuation element 7 to be transmitted from the actuation element 7 to the ejection element 13 and from this finally to a pipette tip attached to the free shaft end 5 of the pipette shaft 4.
  • the actuator 7, the force transmission element 15 and the ejection element 13 are connected to one another in such a way that they can be moved together against the restoring force of the restoring element 12 from their initial position into a ejection position or ejection position.
  • the restoring force of the restoring element 12 then also has the effect that all three previously mentioned elements of the ejection mechanism 6 are automatically moved from their ejection position or ejection position back to their starting position as soon as the actuation element 7 is released again.
  • a diameter of the actuating element 7 is smaller than a diameter of the housing 8 of the pipette 1, i.e. does not protrude laterally or radially with respect to the longitudinal axis L of the pipetting button 3 beyond an outer housing wall of the housing 8.
  • the pipette button 3 of the pipette 1 is arranged centrally on an upper side of the head end 2 of the housing 8 of the pipette 1, so that a longitudinal axis of the pipette 1 is congruent with the longitudinal axis L of the pipette button 3. It should be noted that the longitudinal axis of the actuating element 7, the longitudinal center axis of the pipette shaft 4 and the longitudinal axis L of the pipetting button 3 are also congruent.
  • the actuating element 7 is in its in the Figures 1 and 2 and the starting position shown in FIGS. 4 and 5 relative to the housing 8 of the pipette 1, displaceable axially downwards as well as upwards, but arranged in a rotationally fixed manner relative to the housing 8.
  • the actuating element 7 is relative to the housing with respect to the longitudinal axis L of the pipetting button 1 8 and moved or raised axially upwards relative to the pipetting button 3 of the pipette 1. This takes place against the force of an annular spring 17 a which surrounds a sleeve-shaped extension 18 of the actuating element 7.
  • the actuating element 7 In the volume adjustment position, the actuating element 7 can be rotated about the longitudinal axis L of the pipetting button 3 relative to the housing 8 in order to adjust the volume to be pipetted. In its volume adjustment position, the actuating element 7 can thus be rotated relative to the housing 8 of the pipette 1.
  • the actuating element 7 is not rotatable relative to the housing 8 in its starting position and also in its actuated position for dispensing a liquid, but rather is non-rotatable. In this way, an unintentional volume adjustment can be prevented.
  • the actuating element 7 is in the starting position and in its actuated position non-rotatably relative to the housing 8 due to a locking device 30.
  • This locking device 30 is designed as a toothing 30 and acts between the sleeve-shaped extension 18 of the actuating element 7 and a toothed pressure ring 31.
  • the toothed pressure ring 31 is non-rotatably connected to the force transmission element 15, but axially displaceable relative to this.
  • the actuating element 7 has on the sleeve-shaped extension 18 a toothed ring 32 which engages in teeth of the toothed pressure ring 31 in the initial position and in the actuating position of the actuating element 7. As a result, the actuating element 7 is fixed in its rotational position.
  • the return spring 12 presses the toothed pressure ring 31 against an annular stop 33 which is formed on the inside of the housing 8.
  • actuation of the actuating element 7 ie when the actuating element 7 is pressed down and displaced in the axial direction, it presses with the toothed ring 32 on the toothed pressure ring 31 and moves it axially downwards against the restoring force of the restoring spring 12.
  • the non-rotatable locking of the actuating element 7 is retained even in the actuated position.
  • the toothing 30 is released and the actuating element 7 can be rotated about the longitudinal axis L to adjust the volume of the pipette 1. This is possible because the toothed pressure ring 31 is held back by the ring stop 33 so that it cannot follow the actuating element 7 displaced into its volume adjustment position any further, as a result of which the toothing 30 is released.
  • the volume adjustment of the pipette 1 takes place as described below:
  • the sleeve-shaped extension 18 connected to the actuating element 7 in a rotationally fixed manner has internal teeth 19. Radially outwardly directed external teeth 20 of a spindle sleeve 21 engage in these internal teeth 19.
  • This spindle sleeve 21 is part of the pipetting button 3.
  • the spindle sleeve 21 for its part has an internal thread 22 in which a spindle 23 with an external thread 24 is positioned.
  • the spindle 23 When the spindle sleeve 21 is rotated relative to the spindle 23, the spindle 23 is screwed into or unscrewed from the spindle sleeve 21 according to the direction of rotation.
  • the spindle 23 is connected at a distal end 25 to a piston 26 of the pipette 1.
  • the piston 26 is differently far into a cylinder 27 of the pipette 1 inserted. The deeper the piston 26 is pushed into the cylinder 27, the smaller the volume to be pipetted with the pipette 1.
  • Figure 1 shows particularly well that a radial surface 28 of the actuating element 7 has a non-slip structure in the form of knurling 29.
  • the actuating element 7 of the ejection mechanism 6 of the pipette 1 which can be coupled to the volume adjustment mechanism 11 and is coupled in the position of use, is set up to eject a pipette tip attached to the free shaft end 5 of the pipette 1. This is done in that the actuating element 7 is axially displaced from its starting position into a volume adjustment position relative to the housing 8 of the pipette 1 in relation to the longitudinal axis L of the pipetting button 3. As a result, the toothing 30, as described above, is released. The actuating element 7 can thus be rotated to adjust the volume.
  • the actuating element 7 is rotated in its volume adjustment position on the housing 8 of the pipette 1 around its longitudinal axis, around a longitudinal axis of the pipette 1 and around the longitudinal axis L of the pipetting button 3, the volume to be pipetted is increased or decreased, depending on the direction of rotation.
  • the pipette 1 To improve the handling of a pipette, the pipette 1 according to the invention and a method for setting a volume of a pipette to be pipetted are proposed.
  • the actuating element 7 for actuating the ejection mechanism 6 for ejecting a pipette tip forms a passage 9 for the pipetting button 3.

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  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Devices For Use In Laboratory Experiments (AREA)

Claims (14)

  1. Pipette (1) avec un bouton de pipetage (3), avec une tige de pipette (4) à l'extrémité de tige libre (5) sur laquelle une pointe de pipette peut être fixée ou est fixée et avec un mécanisme de largage (6) comprenant un élément d'actionnement (7) permettant de larguer une pointe de pipette fixée sur l'extrémité de tige libre (5), caractérisée en ce que l'élément d'actionnement (7) forme un passage (9) pour le bouton de pipetage (3), de sorte qu'une surface d'actionnement (10) de l'élément d'actionnement (7) entoure un axe longitudinal (L) du bouton de pipetage (3) sur une plage angulaire d'au moins 180°.
  2. Pipette (1) selon la revendication 1, avec un bouton de pipetage (3), avec une tige de pipette (4) à l'extrémité de tige libre (5) de laquelle une pointe de pipette peut être fixée ou est fixée, avec un mécanisme de largage (6) comprenant un élément d'actionnement (7) permettant de larguer une pointe de pipette fixée sur l'extrémité de tige libre (5) et avec un mécanisme d'ajustage de volume (11) permettant d'ajuster un volume de pipetage d'une pipette (1), caractérisée en ce que l'élément d'actionnement (7) est conçu pour permettre le contrôle du mécanisme d'ajustage de volume (11) et donc l'ajustage du volume de pipetage.
  3. Pipette (1) selon la revendication 1 ou 2, caractérisée en ce que l'élément d'actionnement (7) est conçu comme un bouton rotatif pouvant tourner pour ajuster le volume de pipetage, en particulier autour de l'axe longitudinal (2) du bouton de pipetage (3).
  4. Pipette (1) selon une des revendications 1 à 3, caractérisée en ce que la surface d'actionnement (10) est orientée transversalement ou perpendiculairement à l'axe longitudinal (L) du bouton de pipetage (3) et/ou que la surface d'actionnement (10) entoure l'axe longitudinal (L) du bouton de pipetage (3) de façon annulaire, en particulier de façon circulaire et/ou que le bouton de pipetage (3) dépasse axialement la surface d'actionnement (10) de l'élément d'actionnement (7).
  5. Pipette (1) selon une des revendications précédentes, caractérisée en ce que l'élément d'actionnement (7) peut se mouvoir contre une force de rappel d'un élément de rappel (12), en particulier d'un ressort de rappel (12), d'une position de départ jusqu'à une position d'actionnement, en particulier peut coulisser axialement en direction de l'extrémité de tige libre (5).
  6. Pipette (1) selon une des revendications précédentes, caractérisée en ce que le mécanisme de largage (6) comprend un élément de largage (13) pouvant se mouvoir par rapport à la tige de pipette (4) qui peut coulisser, de préférence axialement, par le biais de l'actionnement de l'élément d'actionnement (7), pour permettre le largage d'une pointe de pipette fixée sur l'extrémité de tige libre (5), par rapport à la tige de pipette (4) en direction de l'extrémité libre (5) de la tige de pipette (4) dans sa position de largage.
  7. Pipette (1) selon une des revendications précédentes, caractérisée en ce que cette pipette (1) présente un élément de transmission de force (15), en particulier un manchon de transmission de force et/ou au moins un bras de transmission de force (17), dans laquelle l'élément de transmission de force (15) relie l'élément d'actionnement (7) avec l'élément de largage (13) et, de ce fait, une force de réglage générée par l'actionnement de l'élément d'actionnement (7) peut être transmise de l'élément d'actionnement (7) à l'élément de largage (13).
  8. Pipette (1) selon une des revendications précédentes, caractérisée en ce qu'un diamètre de l'élément d'actionnement (7) est inférieur ou égal à un diamètre d'un boîtier (8) de la pipette (1).
  9. Pipette (1) selon une des revendications précédentes, caractérisée en ce que le bouton de pipetage (3) est disposé au centre d'une face supérieure d'un ou du boîtier (8) de la pipette (1), de sorte qu'un axe longitudinal de la pipette (1) coïncide avec l'axe longitudinal (L) du bouton de pipetage (3).
  10. Pipette (1) selon une des revendications précédentes, caractérisée en ce que l'élément d'actionnement (7) peut coulisser axialement et est solidaire en rotation dans une ou la position de départ par rapport à un ou au boîtier (8) de la pipette (1) et/ou que l'élément d'actionnement (7) peut être mû d'une ou de la position de départ jusqu'à une position d'ajustage de volume, en particulier peut coulisser axialement par rapport à l'axe longitudinal (L) du bouton de pipetage (3) relativement à un ou au boîtier (8) de la pipete (1), dans laquelle un dispositif de blocage (30) de l'élément d'actionnement (7) permettant de bloquer en rotation l'élément d'actionnement dans sa position de départ peut être desserré par le déplacement vers sa position d'ajustage de volume, de sorte qu'il peut pivoter pour permettre l'ajustage du volume de pipetage dans sa position d'ajustage de volume par rapport au boîtier (8).
  11. Pipette (1) selon une des revendications précédentes, caractérisée en ce qu'une face radiale (28) de l'élément d'actionnement (7) présente une structure antidérapante, en particulier un moletage (29) et/ou un revêtement antidérapant.
  12. Procédé pour permettre l'ajustage d'un volume de pipetage d'une pipette (1) selon une des revendications 1 à 11, caractérisé en ce que le volume de pipetage est ajusté au moyen d'un élément d'actionnement (7) d'un mécanisme de largage (6) de la pipette (1) pouvant être couplé et/ou étant couplé avec un mécanisme d'ajustage de volume (11) de la pipette (1) pour larguer une pointe de pipette fixée sur une extrémité de tige libre (5) de la pipette (1).
  13. Procédé selon la revendication 12, caractérisé en ce que le volume de pipetage est ajusté par la rotation de l'élément d'actionnement (7), en particulier autour d'un axe longitudinal de la pipette (1).
  14. Procédé selon la revendication 12 ou 13, caractérisé en ce qu'un dispositif de blocage permettant de bloquer en rotation l'élément d'actionnement (7) dans une position de départ au niveau d'un boîtier (8) de la pipette (1) est desserré par un déplacement de l'élément d'actionnement (7) de sa position de départ jusqu'à une position d'ajustage de volume au niveau du boîtier (8) de la pipette (1), de sorte que l'élément d'actionnement (7) peut pivoter pour permettre l'ajustage d'un volume de pipetage.
EP17780305.3A 2016-11-14 2017-09-25 Pipette et procédé permettant d'ajuster un volume de pipetage d'une pipette Active EP3538273B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP21157053.6A EP3858486A1 (fr) 2016-11-14 2017-09-25 Pipette et procédé de réglage d'un volume à pipetter d'une pipette

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102016121813.8A DE102016121813A1 (de) 2016-11-14 2016-11-14 Pipette und Verfahren zum Einstellen eines zu pipettierenden Volumens einer Pipette
PCT/EP2017/001141 WO2018086720A1 (fr) 2016-11-14 2017-09-25 Pipette et procédé permettant d'ajuster un volume de pipetage d'une pipette

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP21157053.6A Division EP3858486A1 (fr) 2016-11-14 2017-09-25 Pipette et procédé de réglage d'un volume à pipetter d'une pipette

Publications (2)

Publication Number Publication Date
EP3538273A1 EP3538273A1 (fr) 2019-09-18
EP3538273B1 true EP3538273B1 (fr) 2021-02-17

Family

ID=60022041

Family Applications (2)

Application Number Title Priority Date Filing Date
EP17780305.3A Active EP3538273B1 (fr) 2016-11-14 2017-09-25 Pipette et procédé permettant d'ajuster un volume de pipetage d'une pipette
EP21157053.6A Pending EP3858486A1 (fr) 2016-11-14 2017-09-25 Pipette et procédé de réglage d'un volume à pipetter d'une pipette

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP21157053.6A Pending EP3858486A1 (fr) 2016-11-14 2017-09-25 Pipette et procédé de réglage d'un volume à pipetter d'une pipette

Country Status (5)

Country Link
US (1) US11648550B2 (fr)
EP (2) EP3538273B1 (fr)
CN (1) CN110139715B (fr)
DE (1) DE102016121813A1 (fr)
WO (1) WO2018086720A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3040896B1 (fr) * 2015-09-15 2017-10-13 Gilson Sas Pipette de prelevement comprenant un organe de commande a double fonction d'ejection de cone et de deverrouillage du systeme de reglage de volume
USD876664S1 (en) * 2018-06-13 2020-02-25 Gilson Sas Pipette
CN112044480A (zh) * 2019-06-05 2020-12-08 上海唯问生物技术有限公司 一种新型微量移液器
DE202021101129U1 (de) * 2021-03-05 2022-06-08 Brand Gmbh + Co Kg Pipettiervorrichtung
USD982854S1 (en) * 2022-02-23 2023-04-04 Jinhua Jiu Miao Enterprise Management Co., Ltd. Medicine syringe for a pet
USD982855S1 (en) * 2022-08-19 2023-04-04 Jinhua Jiu Miao Enterprise Management Co., Ltd. Medicine syringe for a pet

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766785A (en) * 1971-05-17 1973-10-23 Analytical Prod Automatic pipette
US3853012A (en) * 1971-10-04 1974-12-10 Medical Laboratory Automation Pipettes
FR2287941A1 (fr) * 1974-10-15 1976-05-14 Marteau D Autry Eric Dispositif d'ejection de l'embout amovible d'une pipette
DE2541642C3 (de) * 1975-09-18 1979-07-26 Labora Mannheim Gmbh Fuer Labortechnik, 6800 Mannheim Pipertier-Handpipette
US4023716A (en) * 1976-04-20 1977-05-17 Justin Joel Shapiro Micro-dispensing liquid pipet
FI57540C (fi) * 1977-02-17 1980-09-10 Suovaniemi Finnpipette Anordning foer att loesgoera och avlaegsna en engaongsspets pao en pipett
DE2711124C2 (de) * 1977-03-15 1979-05-10 Labora Mannheim Gmbh Fuer Labortechnik, 6800 Mannheim Handpipette
FR2474340A1 (fr) * 1980-01-11 1981-07-31 Marteau D Autry Eric Pipette a deplacement positif perfectionnee
US4418580A (en) * 1981-10-13 1983-12-06 Sherwood Medical Company Pipettor mechanism and disposable tip and piston assembly
US4988481A (en) * 1989-01-30 1991-01-29 Labsystems Oy Electrical pipette
US5104625A (en) * 1989-10-04 1992-04-14 Drummond Scientific Company Pipetter device
FI921765A0 (fi) * 1992-04-21 1992-04-21 Labsystems Oy Med en spetsavlaegsnare foersedd pipett.
US6329139B1 (en) * 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
DE19708151C2 (de) * 1997-02-28 1999-05-27 Eppendorf Geraetebau Netheler Pipettiervorrichtung
US6295880B1 (en) * 1999-12-08 2001-10-02 Warren E. Gilson Adjustable pipette
US6352673B1 (en) * 2000-03-09 2002-03-05 Rainin Instrument Ergonomic return springless manual air displacement pipette
FI20002241A0 (fi) * 2000-10-11 2000-10-11 Labsystems Oy Säädettävä pipetti
FI20031683A0 (fi) * 2003-11-19 2003-11-19 Thermo Electron Oy Pipetti jossa on kärjenpoistomekanismi
FR2862888B1 (fr) * 2003-11-27 2006-07-07 Gilson Sas Procede d'affichage d'une valeur d'un volume d'un echantillon liquide a prelever avec une pipette, a precision amelioree
DE102007010299B4 (de) * 2007-03-02 2009-01-29 Eppendorf Ag Handpipettiervorrichtung
FI120672B (fi) * 2008-03-28 2010-01-29 Thermo Fisher Scientific Oy Nupillinen pipetti
DE102008048252A1 (de) * 2008-09-12 2010-04-15 Eppendorf Ag Pipettiervorrichtung
PL220934B1 (pl) * 2009-08-28 2016-01-29 PZ HTL Spółka Akcyjna Pipeta mechaniczna z nastawianą wartością objętości pobieranej cieczy
JP2011115759A (ja) * 2009-12-07 2011-06-16 Fukae Kasei Kk ピペット装置
CN202113872U (zh) * 2011-05-13 2012-01-18 梅方敏 一种可调微量移液器
FR2980123B1 (fr) * 2011-09-19 2013-10-11 Gilson Sas Pipette a deplacement positif presentant une fonction d'ejection amelioree
DE102012002169B4 (de) * 2012-02-07 2017-02-09 Eppendorf Ag Pipette
PL2656915T3 (pl) * 2012-04-23 2019-04-30 Eppendorf Ag Pipeta do uruchamiania strzykawki
FR3003643B1 (fr) * 2013-03-25 2015-04-17 Gilson Sas Systeme de pipetage a deplacement positif presentant une fonction d'ejection amelioree
FR3012883B1 (fr) * 2013-11-07 2015-12-25 Gilson Sas Systeme de pipetage a deplacement positif, presentant une conception facilitant la prehension du piston de l'ensemble capillaire-piston
AU2016248939B2 (en) * 2015-04-16 2018-03-29 Integra Biosciences Ag Volume adjustment for manual pipettor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
None *

Also Published As

Publication number Publication date
CN110139715B (zh) 2021-10-12
EP3858486A1 (fr) 2021-08-04
EP3538273A1 (fr) 2019-09-18
WO2018086720A1 (fr) 2018-05-17
US20190366323A1 (en) 2019-12-05
US11648550B2 (en) 2023-05-16
DE102016121813A1 (de) 2018-05-17
CN110139715A (zh) 2019-08-16

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