EP3479857A1 - Dichtung zum verriegeln einer spritze - Google Patents

Dichtung zum verriegeln einer spritze Download PDF

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Publication number
EP3479857A1
EP3479857A1 EP17199879.2A EP17199879A EP3479857A1 EP 3479857 A1 EP3479857 A1 EP 3479857A1 EP 17199879 A EP17199879 A EP 17199879A EP 3479857 A1 EP3479857 A1 EP 3479857A1
Authority
EP
European Patent Office
Prior art keywords
seal
syringe
plunger
pin
receiving
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP17199879.2A
Other languages
English (en)
French (fr)
Inventor
Eli Carl Ferre DIJKERS
Paul Herman STOB
Reinier Floris Hendricus VEENENDAAL
Natasja SEGHER
Esther Helina JAGER
Louise Maria VERHOEVEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fagron BV
Original Assignee
Fagron BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fagron BV filed Critical Fagron BV
Priority to EP17199879.2A priority Critical patent/EP3479857A1/de
Priority to EP18793679.4A priority patent/EP3703793A1/de
Priority to PCT/EP2018/079978 priority patent/WO2019086590A1/en
Publication of EP3479857A1 publication Critical patent/EP3479857A1/de
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A61M2005/31508—Means for blocking or restricting the movement of the rod or piston provided on the piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production

Definitions

  • the current invention in most general terms relates to ready-to-use prefilled syringes. More in particular, the invention relates to a seal for locking the plunger of a syringe at any pre-selected position relative to the syringe barrel, by clamping the plunger shaft and the grip of the syringe barrel together.
  • the invention also relates to an assembly comprising the seal of the invention and a syringe.
  • the syringe is typically a pre-filled syringe provided with a capped needle in the assembly of the invention.
  • the seal of the invention is typically for use in sealing a syringe prefilled with a medicament.
  • the invention relates to a syringe provided with a seal of the invention.
  • the invention also relates to a mold for molding the seal of the invention.
  • the invention relates to a computer readable medium comprising computer executable instructions and 3D data representing the seal of the invention, which instructions and 3D data, when loaded on a computer system connected to a 3D printer, allows to 3D print the seal of the invention.
  • Fluids such as liquid medicaments can be relatively expensive.
  • the procedure of manufacturing a medicament can be costly, and/or the active pharmaceutical ingredient can be costly.
  • use of e.g. medicaments generally requires a high standard of care, in-depth knowledge and well-trained skills. That is to say, not only the act of administration of a medicament such as in particular an injectable medicament, requires extreme care and a high level of skills.
  • the administered amount and dose of a medicament is of extreme importance to the well-being and health of the subject to whom the medicament is administered and is of extreme importance in view of the (desired) effect of the medicament and perhaps also in view of the prevention or control of adverse side effects coming with the use of the medicament in a body, e.g. a human body.
  • a body e.g. a human body.
  • Both administering by injection a too small amount of a medicament to a subject, and to the opposite a too large amount, may induce serious consequences in the injected subject.
  • Great effort is therefore required in order to prevent errors with regard to the administered amount and dose of a medicament to a subject.
  • the quality and effectivity and volume in e.g. a prefilled syringe, of a medicament released by a manufacturer for use in a subject should be stable and stored for a sufficiently amount of time.
  • a prefilled syringe should be stabilized and made resistant with regard to any mechanical forces exposed to the syringe during e.g. transport and storage.
  • Quality, effectivity and volume of a medicament are all compromised in time by external influences such as temperature, drops and rises in temperature, exposure to ultraviolet light, etc., etc.
  • a prefilled syringe such as a prefilled syringe provided with a needle
  • the material of the syringe as well as of the needle may exert an influence on the medicament in the syringe. Leakage from the syringe may occur.
  • the medicament may become less efficacious during time due to for example chemical reactions and/or physical interactions between the medicament and syringe/needle material.
  • liquid medicament entering the needle after filling, during storage and as a result of movement of the plunger due to any mechanical forces acting upon the prefilled syringe during e.g. transport may result in one or more of a number of devastating outcomes with regard to the quality and effectivity of e.g. a liquid medicament such as an aqueous pharmaceutical composition.
  • an additional problem encountered with providing a ready-to-administer pharmaceutical composition in a syringe with a needle is keeping the syringe and thus the pharmaceutical composition free from contamination with any microbes during storage and transport up to the moment at which the pharmaceutical composition is to be administered to a subject.
  • providing a prefilled syringe filled with a pharmaceutical composition with a needle comes with the risk for spoiling and/or contaminating the pharmaceutical composition when connecting the needle to the syringe and during subsequent storage and transport of the ready-to-use syringe.
  • One approach to address one or several of the above outlined safety issues, etc. is to store a fluid in a syringe, e.g. a liquid medicament in a prefilled syringe, by locking the predetermined volume of the medicament in the syringe by application of a seal for fixation of the syringe plunger to the barrel of the syringe.
  • a fluid e.g. a liquid medicament in a prefilled syringe
  • a seal for fixation of the syringe plunger to the barrel of the syringe.
  • prefilling a syringe with a predetermined unit dose of a medicament and then locking the syringe by use of a seal greatly contributes to the avoidance of errors with regard to administering the correct dose to a subject.
  • conserving a fluid such as a liquid medicament in a syringe by use of a seal provides the possibility to check and control whether the syringe remained untampered during, e.g. production, transport, storage, up to the act of breaking the seal and administering the e.g. liquid medicament to a patient.
  • Dutch patent NL1038569 describes a seal for clamping the shaft of a plunger of a syringe at a predetermined fixed position.
  • the seal of NL1038569 is designed for use with syringes having a plunger shaft with a selected single shape and size and having a grip at the barrel of the syringe, which grip has a selected single shape and size, which selected shape and size of the plunger shaft and of the grip fit with notches and apertures of the seal.
  • Different syringes with different plunger shafts and/or different grips require different seals, according to NL1038569 .
  • the seal of NL1038569 is either provided as a seal which can be reversibly locked once clamped to a syringe, or is provided as a seal which is irreversibly locked once clamped to a syringe. Consequently, breaking the seal results in the seal falling apart in at least two parts, based on the drawings of NL1038569 .
  • European patent application EP04735043 relates to means for limiting the dose that may be dispensed by a syringe, and describes a seal for mounting on the plunger of a syringe, at a position at any location along the plunger shaft.
  • the seal consists of two hinging parts both comprising notched portions for receiving the arms of the cross of a plunger-shaft formed as a cruciform, when the seal is in locked position.
  • the notched portions are provided with clamping pins for embedding into the plunger to prevent sliding of the seal relative to the plunger.
  • the two hinging parts each comprise the complementary part of a lock.
  • the seal of EP04735043 once applied to a plunger of a syringe, permanently prevents retraction of the plunger head relative to the syringe barrel beyond a predetermined distance.
  • United Kingdom patent GB2377176 relates to a seal for use in controlling the administration of a drug by a syringe, wherein the seal is locatable upon the syringe.
  • the seal is not tamper proof, or tamper evident, and the seal is selectively movable between a locked position in which the syringe is prevented from moving the plunger of the syringe, and an unlocked position which allows the plunger of the syringe being moved.
  • the seal is releasably secured to the syringe such that the seal is in locked position, and the seal is configured to unlock from the plunger such that the plunger can be moved.
  • the seal comprises two pivotally connected parts, said parts comprising a releasable lock means.
  • the two hinging parts of the seal both comprise notched portions for receiving the arms of the cross of a plunger-shaft formed as a cruciform, when the seal is in locked position as well as when the seal is unlocked such that the plunger of the syringe is moveable.
  • International patent application WO 01/023017 relates to a seal for locking the plunger of a syringe at a predetermined position relative to the barrel of the syringe, thereby preventing movement of the syringe plunger relative to said barrel.
  • the seal both encapsulates the grip of the syringe plunger and receives the grip of the syringe barrel, when the seal is applied to the syringe plunger, thereby limiting the dynamic range of locked positions of the plunger relative to the barrel.
  • the seal of WO 01/023017 is not tamper evident, or tamper proof. According to WO 01/023017 , different seals are to be manufactured, the seals having different sizes to accommodate various syringe sizes and volumes of medicament to be contained by the syringes.
  • an improved seal that fills in the shortcomings of current seals is highly desired in the field of e.g. manufacturing of precious solutions such as costly liquid medicaments, such solutions subsequently brought in a barrel such as a syringe barrel.
  • the current invention relates to a seal that provides a solution to many, if not all, of the shortcomings of seals currently applied in the field of manufacturing syringes prefilled with any precious fluid such as a liquid medicament, for example an aqueous pharmaceutical composition.
  • the seal of the invention is a tampered proof seal. The seal is placed and positioned on the plunger shaft of a syringe and on the grip of the syringe barrel with great ease, without the requirement of substantial skills and force.
  • the use of the seal of the invention provides for a convenient method of placing a seal to a (prefilled) syringe.
  • Clamping such a seal of the invention to a syringe does not introduce a risk for developing injuries to for example muscles and tendons and nerves of the hand and arm of the persons providing syringes with the seal of the invention, even when seals are clamped to syringes for prolonged periods of time during a day, and for prolonged periods of time during weeks and months.
  • Clamping a seal of the invention to a syringe only requires the closure of a single lock, said lock for example comprising a bulged pin - slot configuration.
  • the seal of the invention is easily removable from the syringe, even with one hand, without applying a high amount of force.
  • the seal of the invention is applicable with a wide array of different syringes having plungers with shafts having varying shapes and sizes and a multitude of syringe barrel volumes and variously sized and shaped barrel grips. As a result, greater flexibility is afforded to the user of the seal of the invention by the use of the seal.
  • the current invention relates to a seal for locking a plunger of a syringe, the seal comprising
  • the seal according to the invention has a lock with a slot with an opening which opening is provided with a rim portion, preferably a resilient rim portion.
  • the seal according to the invention comprises a lock with a slot, wherein the rim portion of opening of the slot is provided with at least one notch, preferably two notches located at opposite sides of the rim, more preferably four notches positioned at a mutual angle of about 90° relative to one another.
  • the seal according to the invention comprises a lock with a slot, wherein the rim portion of opening of the slot is provided with at least one notch, preferably two notches located at opposite sides of the rim, more preferably four notches located at an angle of about 90° relative to one another.
  • the seal according to the invention comprises a lock comprising a pin, wherein the bulged end portion in the end portion of the pin is an enlarged head encompassing the end portion, or is a rim, or is a harpoon of a harpoon closure encompassing the end portion, or is the first half of a snap closure for engagement with the second half of a snap closure located in the slot, or is the first half of an interlocking closure for engagement with a second half of an interlocking closure located in the slot.
  • the seal according to the invention comprises a lock with a slot, wherein the pin of the slot is provided with a resilient bulged portion.
  • the seal according to the invention comprises a lock with a slot, wherein the pin of said slot is provided with a handle arranged to release the pin from the first part of the seal.
  • the seal according to the invention comprises at least one of a thermosetting polymer material selected from the group comprising polystyrene and polycarbonate, and/or one of a thermoplastic polymer material selected from acrylonitrile butadiene styrene and acrylonitrile styrene acrylate, preferably, the seal is manufactured from polystyrene.
  • a thermosetting polymer material selected from the group comprising polystyrene and polycarbonate
  • a thermoplastic polymer material selected from acrylonitrile butadiene styrene and acrylonitrile styrene acrylate
  • the seal is manufactured from polystyrene.
  • the seal of the invention may also comprise other polymers or a polymer blend, according to the invention.
  • the seal according to the invention is manufactured from a single type of thermosetting polymer material selected from polystyrene and polycarbonate, or is manufactured from a single type of thermoplastic polymer material selected from acrylonitrile butadiene styrene and acrylonitrile styrene acrylate, preferably, the seal is wholly manufactured from polystyrene.
  • the seal of the invention is manufactured from a single polymer blend known in the art.
  • the seal according to the invention comprises a first part and a second part, each part provided with a notched portion for receiving the plunger of a syringe, wherein the notched portion of said first and second part is configured for step less receiving a plunger shaft of the plunger.
  • the seal according to the invention comprises a first part and a second part, wherein said first and second part each is provided with at least two apertures for receiving the grip of the syringe, which grip is part of the barrel of the syringe.
  • An aspect of the invention is a seal for locking a plunger of a syringe, the seal comprising
  • the seal according to the invention further comprises
  • the seal according to the invention further comprises
  • the seal according to the invention comprises a first and second part, wherein said first and second part each is provided with at least two apertures for receiving the grip of a syringe and wherein the apertures are arranged for receiving grips with different dimensions and/or with a different shape.
  • the seal according to invention comprises a first part and a second part, each part provided with a notched portion for receiving the plunger of a syringe, wherein the notched portions of the first and second parts form a circular opening when the seal is in the locked position, wherein the notched portions are arranged conform a circular shape for receiving the plunger-shaft of the plunger of the syringe.
  • the seal according to the invention comprises a first part and a second part, each part provided with a notched portion for receiving the plunger of a syringe, wherein the notched portions of the first and second parts form a circular opening when the seal is in the locked position, wherein the notched portions are arranged conform a circular shape for receiving the plunger-shaft of the plunger of the syringe, and wherein each notched portion further comprises at least two clamping pins positioned at a mutual angle of 90° such that the at least four clamping pins are respectively positioned at a mutual angle of 90° in the circular opening formed by notched portions when the seal is in the locked position.
  • Such clamping pins are provided for embedding into the shaft of the syringe plunger to aid in prevention of sliding of the seal relative to the plunger shaft, once the seal is clamped to a syringe.
  • the seal according to the invention comprises a first part and a second part, each part provided with a notched portion for receiving the plunger of a syringe, wherein the notched portions of the first and second part are each provided with a notch and a first and second recess portion in the first part and a first and second recess portion in the second part, such that each of the notches and opposite recess portions of the notched portions are arranged conform a cruciform for receiving a plunger-shaft, when the seal is in locked position.
  • the seal according to the invention comprises a first part and a second part, each part provided with a notched portion for receiving the plunger of a syringe, wherein the notched portions of the first and second parts form a circular opening when seal is in the locked position, wherein the notched portions are arranged to receive conform a circular shape for receiving the plunger-shaft of the plunger, and wherein the notched portions of the first and second part are each provided with a notch and a first and second recess portion in the first part and a first and second recess portion in the second part, such that each of the notches and opposite recess portions of the notched portions are arranged conform a cruciform for receiving a plunger-shaft, when the seal is in locked position.
  • a third aspect of the current invention is an assembly comprising the seal according to the invention and a syringe.
  • the syringe is further provided with a needle connected to a nozzle of the syringe, said needle preferably provided with a releasable cap.
  • a fourth aspect of the current invention is a syringe provided with a seal according to the invention.
  • a fifth aspect of the current invention is a mold for molding the two parts of the seal of the invention.
  • the seal is made of a single material such as a polymer or a polymer blend, preferably the seal is made of polystyrene.
  • a sixth aspect of the current invention is a computer readable medium comprising computer executable instructions and 3D data representing the seal of the invention, which, when loaded on a computer system connected to a 3D printer, allows to 3D print the two parts of the seal.
  • a further aspect of the current invention is a computer system comprising a processor, a memory and a 3D printer, which processor is arranged to execute instructions stored in said memory, for 3D printing of the two parts of the seal of the invention by said 3D printer.
  • stamper proof also referred to as "tamper resistance”
  • tamper resistance has its normal scientific meaning throughout the application and here refers to the resistance to tampering (intentional malfunction or sabotage) by a user of e.g. a product which is meant to remain untampered, e.g. up till the intended specific use of said product.
  • a product is made tamper proof by applying a seal to the product. Then, a broken or torn seal is a measure or indication for the initially sealed product not being untampered anymore.
  • seal 1, 50, 60 is for locking a plunger 14 of a syringe 15, 15' by clamping the shaft of the plunger 17, 25, 26 to the grip 16 of the syringe said grip located at the syringe barrel 18.
  • the seal 1, 50, 60 comprising
  • the lock 7 is arranged such that movement of the first and second parts 2, 3, 47, 46 from the locked position to an open position of the seal is prevented once the seal is locked. That is to say, in the locked position of the seal movement of the two first and second parts 2, 3, 47, 46 from the locked position to the open position of the seal is prevented when an opening 9 of the slot 7' is engaged by the bulged portion 8' of the pin 8.
  • the seal 1, 50, 60 of the invention is provided such that the first part and the second part 2, 3, 47, 46 and the hinge 6, 6a, 6b are integrated into a single piece according to the invention.
  • the seal 1, 50, 60 is provided with a removable seal 12, which is for example a breakable seal or a tearable seal, such that the seal 1, 50, 60 is intentionally removable from a syringe to which the seal is clamped, by breaking or tearing the removable seal 12.
  • the removable seal 12 is tearable or breakable without leaving sharp edges and/or sharp parts after tearing or breaking the seal. It is an important aspect of the current invention that tearing or breaking the removable seal 12 results in the seal 1, 50, 60 being removable from a syringe, while said seal remains a single part, without the seal falling apart in more than one pieces or elements.
  • the seal of the invention provides for various benefits when compared to seals currently applied to e.g. syringes. That is to say, removal of the seal of the invention from a syringe comes with a reduced risk for (uncontrolled) scattering of (tiny, sharp, harmful) pieces of seal, to the benefit for e.g. a user of the sealed syringe or a patient in an operation room or a hospital setting.
  • the user of the sealed syringe is exposed to less risk for torn gloves such as surgeon gloves when tearing the seal, and exposed to less risk for cutting the skin of e.g. the fingers and the hand.
  • the seal of the invention introduces less risk for contacting the patient's body with parts of the seal and thus lowers the risk for contaminating the patient's body with any microbe that may be adhered to parts of the seal, when compared to current seals that fall apart uncontrollable when opened.
  • the removable seal 12 is tearable leaving edges after tearing the seal which edges have a surface that introduces a smaller risk for tearing e.g. surgeon gloves when contacting or moving such gloves along the surface of said edges, when compared to the edges that are exposed when tearing seals currently available.
  • the pin 8 remains engaged in the slot 7' upon tearing/breaking the removable seal 12 thereby disconnecting the pin 8 from the first portion 2, 47 of the seal 1, 50, 60.
  • the pin 8 remains engaged in the slot 7' when the removable seal 12 is removed such that the pin 8 is disconnected from the first portion 2, 47 of the seal 1, 50, 60.
  • rim portion 10 of the opening 9 of the slot 7' is provided with at least one notch 11, preferably two notches 11 located at opposite sides of the rim, more preferably four notches 11 located at a mutual angle of about 90° relative to one another.
  • the bulged end portion 8' may have one or more of many possible shapes and sizes, that all are fit to the purpose of being able to engage the opening 9 while being not able to be relieved from the slot 7'once the bulged end portion 8' passed the opening 9.
  • the seal 1, 50, 60 of the invention comprises a pin 8 releasably connected to the first part 2, 47 of the seal, wherein the bulged end portion 8' in the end portion 13 of the pin 8 is either an enlarged head encompassing the end portion 13, or is a rim (not shown), or is a harpoon of a harpoon closure (not shown) encompassing the end portion 13, or is the first half of a snap closure for engagement with the second half of a snap closure located in the slot 7' (not shown), or is the first half of an interlocking closure for engagement with a second half of an interlocking closure located in the slot 7' (not shown), to name a few possible means for irreversibly locking pin 8 in slot 7'.
  • the applicable means and method for closing and locking the seal 1, 50, 60 of the invention are thus numerous, as long as the seal is tamper proof with regard to said closing and locking means.
  • the closing and locking means of the seal of the invention are resistant to tampering; the seal of the invention is removed from a syringe by breaking/tearing the removable seal 12, according to the invention.
  • Preferred is a seal 1, 50, 60 of the invention comprising closing and locking means consisting of a pin 8 releasably connected to the first part 2, 47 of the seal, wherein the pin 8 comprises a bulged end portion 8' configured for engagement with the opening 9 of slot 7' (See for example Figure 1 , 3 , 4 and 7 ).
  • the seal 1, 50, 60 can be provided with a pin 8 which pin is provided with a handle 21 arranged to release the pin 8 from the first part 2 of the seal 1, 50, 60 by facilitating the breaking/tearing of the removable seal 12.
  • a handle 21 arranged to release the pin 8 from the first part 2 of the seal 1, 50, 60 by facilitating the breaking/tearing of the removable seal 12.
  • the user of the seal 1, 50, 60 is able to tear/break the removable seal 12 upon applying a reduced amount of force, due to the leverage, when compared to the force required to remove current seals applied to syringes or when compared to the force required to break or tear the removable seal 12 when the pin 8 is not provided with such a handle 21 or the like.
  • the pin 8 is provided with a handle 21, wherein the pin 8 is released from the first part 2 of the seal by rotating the pin 8 along its longitudinal axis over for example between about 45° to 180°, preferably less, or preferably over for example between 90° and 120° such as about 100°, such that the removable seal 12 is torn or broken from the first part 2 and such that the pin 8 is disconnected from the first part 2 while remaining engaged in the slot 7'.
  • the part 2 of the seal 1, 50, 60 is provided with a pin 8 comprising a resilient bulged portion 8'.
  • a resilient bulged portion 8' is for example made of a rubber or a polymer such as a polymer blend or a single polymer such as polystyrene. Applying a resilient bulged portion 8' provides the benefit of a more easy engagement of the pin 8 by the slot 7', requiring less force by the user of the seal.
  • the seal 1, 50, 60, and in particular its casing, i.e. the parts 2 and 3 of the seal, can be manufactured from many different materials.
  • manufacturing the seal of the invention from a polymer or polymer blend is preferred.
  • the seal 1, 50, 60 of the invention comprises for example at least one of a thermosetting polymer material selected from the group comprising polystyrene and polycarbonate, and/or comprises for example one of a thermoplastic polymer material selected from acrylonitrile butadiene styrene and acrylonitrile styrene acrylate.
  • a seal produced from combinations of said thermosetting polymers and/or thermoplastic polymers is part of the invention.
  • the seal 1, 50, 60 is manufactured from a single type of polymer or polymer blend, most preferably at least part of the seal, including the removable seal 12 is made of polystyrene.
  • the seal 1, 50, 60 of the invention is manufactured from a single type of thermosetting polymer material selected from polystyrene and polycarbonate, or is manufactured from a single type of thermoplastic polymer material selected from acrylonitrile butadiene styrene and acrylonitrile styrene acrylate.
  • the seal 1, 50, 60 is wholly manufactured from polystyrene. The inventors noticed that the first and second part of the seal of the invention are conveniently produced from polystyrene, and that tearing or breaking the removable seal 12 is then relatively easy, requiring minimum force.
  • the first and second parts 2, 3, 47, 46 of the seal 1, 50, 60 of the invention are provided with a notched portion 5, 5', which notched portions are configured such that the shaft 17, 25, 26 of a syringe plunger is steplessly receiveable by the seal.
  • Receiving the plunger shaft steplessly provides the benefit of freedom of providing a prefilled syringe with seemingly endless variation of the volume of e.g. the liquid medicament such as a pharmaceutical composition, e.g. for use in the treatment of a cancer, diabetes, myocardial infarction, sepsis, etc.
  • the seal of the invention for a prefilled syringe is for example particularly suitable for providing a pharmaceutical composition for use in the treatment of degenerative eye disease such as a pharmaceutical composition for use in the eye of a patient suffering from macular degeneration. That is to say, first a syringe can be filled with any predetermined desired volume of a fluid, e.g. a liquid medicament, and then the seal 1, 50, 60 can be clamped to the plunger shaft and to the grip of the syringe, without restrictions with regard to the position of the plunger shaft relative to the syringe barrel.
  • a fluid e.g. a liquid medicament
  • a seal 1, 50, 60 is provided for universal application with regard to the volume of liquid medicament present in the syringe barrel, since the seal is configured for receiving a plunger shaft pulled out of the syringe barrel to any possible extent.
  • the syringe is first filled with a volume of a liquid medicament of between about 25 microliter and 2 ml or higher, such as 25 microliter, 40, 50, 60, 70, 80, 90, 100, 150, 200, 500 microliter, 1, 1,5 ml, or with any volume of a liquid medicament in between these indicated volumes.
  • syringes of applicable volume such that a seal of the invention is subsequently attached to the syringe plunger and grip of the syringe.
  • a syringe suitable for containing at maximum 2 ml is prefilled with 1 ml of a liquid medicament, and subsequently the seal 1, 50, 60 of the invention is clamped to the plunger shaft of the syringe and concomitantly to the grip of the syringe.
  • the seal 1, 50, 60 is applied to syringes having a capacity for containing at maximum for example 500 microliter, 1 ml, 5 ml, 10 ml, 20 ml, 25 ml, 50 ml or even 100 ml of a fluid such as an aqueous pharmaceutical composition.
  • the seal of the invention is clamped to a prefilled syringe, said prefilled syringe being provided with a needle.
  • a syringe barrel comprising a grip at the barrel-end configured for receiving the syringe plunger.
  • a grip of a syringe comprises a transverse flange portion.
  • the at least one aperture 4, 4', 20 in the first and second parts 2, 3, 47, 46 of the seal for receiving a grip 16 of a syringe is an aperture configured for receiving a transverse flange portion of a grip of the barrel 18 of a syringe.
  • the aperture(s) can have different sizes and shapes when configured for receiving grips of syringes having variant sizes and/or shapes.
  • the first and second part 2, 3, 47, 46 of seal 1, 50, 60 each is provided with at least two apertures 4, 4', 20 for receiving the grip 16 of the syringe 15, 15'.
  • the first and second part 2, 3, 47, 46 of seal 1, 50, 60 each is provided with two apertures 4, 4', 20, wherein each aperture is configured to receive a grip with a certain size and/or shape, and in combination the apertures are configured to receive various grips with varying sizes and/or shapes.
  • Such a seal 1, 50, 60 of the invention comprising at least two differently sized and/or shaped apertures for receiving a variety of differently sized and/or shaped grips of syringes, provides for a highly flexible application of the seal, with virtually no restriction as to the type and size and shape of syringe to which the seal is clamped.
  • the seal 1, 50, 60 of the invention is applicable with many if not all syringes currently applied in healthcare, etc., for administering for example liquid medicament to a subject, e.g. a human subject.
  • the seal 1, 50, 60 comprises a first and a second part 2, 3, 47, 46 each provided with at least two apertures 4, 4', 20 for receiving a grip 16 of a syringe 15, 15' and wherein the separate apertures in each part are arranged for receiving grips with different dimensions and/or with a different shape.
  • a seal 1, 50, 60 is provided for locking a plunger 14 of a syringe 15, 15', the seal 1, 50, 60 comprising
  • the notched portion 5, 5' is configured to receive the plunger shaft 17, 25, 26 of a plunger 14 of a syringe such that the seal 1, 50, 60 is clamped to said plunger shaft when the seal is in locked position.
  • the seal 1, 50, 60 of the invention comprises
  • the seal 1, 50, 60 of the invention comprises
  • the current invention provides for a tamper proof seal 1, 50, 60 for locking the shaft 17 of a plunger 14 at any pre-selected position, such as for example a predetermined position 17' of the plunger shaft in the barrel 18 of a syringe 15, 15'.
  • a liquid medicament contained in a prefilled syringe sealed with a seal 1, 50, 60 of the invention is stored and liquid cannot enter the needle that is optionally provided at the supply end of the syringe barrel.
  • the volume of a liquid in the prefilled syringe locked with a seal 1, 50, 60 of the invention is stable and the quality of the liquid such as a liquid medicament is not influenced by for example exposure to needle material.
  • a syringe 15' provided with a shaft 25 having a substantially cylindrical shape, preferably a cylindrical shape.
  • the seal 50 of the invention comprises a first part 2 and a second part 3, provided with notched portions 5, 5' forming a substantially circular opening, preferably a circular opening 35 when seal 50 is in the locked position, wherein the notched portions 5, 5' are arranged conform a circular shape for receiving the plunger-shaft 25 of the plunger 14 of the syringe 15'.
  • a seal 50 is provided suitable for receiving a cylindrically shaped plunger-shaft having a certain fixed radius, i.e.
  • a plunger shaft with an essentially circular cross-section or that seal 50 is provided suitable for receiving various different cylindrically shaped plunger-shafts having a varying radius, i.e. various plunger shafts each with an essentially circular cross-section wherein the diameter of these cross-sections may vary between different shafts, wherein the seal fits with shafts having relatively smaller radius as well as with shafts having a larger radius, according to the invention.
  • various plunger shafts each with an essentially circular cross-section wherein the diameter of these cross-sections may vary between different shafts, wherein the seal fits with shafts having relatively smaller radius as well as with shafts having a larger radius, according to the invention.
  • providing a seal arranged for receiving shafts of plungers with a certain range of shaft radius is preferred since such a seal of the invention is more universally applicable.
  • the seal 1, 50 of the invention comprises a first part 2 and a second part 3, each part provided with a notched portion 5, 5' for receiving the plunger 14 of a syringe 15, wherein the notched portions 5 5' of the first and second parts 2, 3 form a circular opening 35 when the seal 1, 50 is in the locked position, wherein the notched portions 5, 5'are arranged conform a circular shape for receiving the plunger-shaft 25 of the plunger 14 of the syringe 15, and wherein each notched portion 5, 5' further comprises at least two clamping pins 36, 36', 37, 37' positioned at a mutual angle of 90° such that the at least four clamping pins are respectively positioned at a mutual angle of 90° in the circular opening 35 formed by notched portions 5, 5' when the seal 1, 50 is in the locked position
  • the clamping pins aid in fixation and immobilization of the plunger at a (pre-selected) position relative to the syringe barrel, by improving the grip of the seal on the substantially cylindrical plunger shaft of the syringe.
  • the notched portions 5, 5' are provided with at least one, such as two, three, four, five, six, etc., clamping pins, with the aim of further strengthen the grip of the seal in locked position on the plunger.
  • the clamping pins are an integral part of the part 2 and part 3 of the seal 1, 50, and preferably, said clamping pins, such as ridges, bulbs, or the like, are made of the same material as the whole of part 2 and part 3 of the seal.
  • a seal of the invention is completely made of polystyrene, but also other polymers and polymer blends are suitable materials for manufacturing a seal of the invention comprising notched portions with clamping pins.
  • the seal 60 of the invention comprises a first part 47 and a second part 46, provided with notched portions 5, 5' forming a recess arranged for receiving a cruciform shaped body, wherein the notched portions 5, 5' of the first and second part 47, 46 are each provided with a notch 44, 44' and a first and second recess portion 45 in the first part 47 and a first and second recess portion 45' in the second part 46, such that each of the notches 44, 44' and opposite recess portions 45, 45' of the notched portions are arranged conform a cruciform for receiving a plunger-shaft 17, 26, when the seal 60 is in locked position.
  • the seal 60 of this embodiment is applicable for a wide array of currently used syringes. It is appreciated that the dimensions of the notched portions 5, 5' are adaptable to the individual size and/or shape of such syringes having a plunger shaft having the cross-sectional shape of a cruciform.
  • a single seal 1, 60 of the invention is adapted for receiving various plunger shafts having the cross-sectional shape of a cruciform, wherein the shape and dimensions of such cruciform varies within certain ranges.
  • the seal 1, 60 of the current embodiment is applicable for receiving the plunger shaft of a wide range of different syringes with a variety of cross-sectional shaped plungers having different sizes and shapes.
  • the seal 1 of the invention comprises a first part 2 and a second part 3 provided with notched portions 5, 5' forming a recess arranged for receiving a cruciform shaped body as well as arranged for receiving a cylindrically shaped body, when the seal is in locked and closed position.
  • the seal 1 of the invention comprises a first part 2 and a second part 3, each part comprising a notched portion 5, 5', wherein the notched portions 5, 5' of the first and second parts 2, 3 form a circular opening 35 when seal 1 is in the locked position, wherein the notched portions 5, 5' are arranged conform a circular shape for receiving the plunger-shaft 25 of the plunger 14 of a syringe, and wherein the notched portions 5, 5' of the first and second part 2, 3 are each provided with a notch 30, 30' and a first and second recess portion 31, 32 in the first part 2 and a first and second recess portion 33, 34 in the second part 3, such that each of the notches 30, 30' and two opposite recess portions 31, 33 and two opposite recess portions 32, 34 of the notched portions are arranged conform a cruciform for receiving a plunger-shaft, when the seal 1 is in locked position.
  • the seal 1 is arranged for receiving virtually all plunger shafts nowadays in use for e.g. healthcare applications, said plunger shafts having a substantially cylindrical cross section or having a cross section as a cruciform, or having a plunger shaft with a cross section which is a combination of a cylindrical cross section and a cross section as a cruciform. It is one of the many advantages of the seal of the current invention, that the seal is applicable with virtually all syringes in use in the field of medicine, healthcare, etc., etc.
  • the seal 1 of the invention arranged for receiving a plunger shaft having a cylindrical cross section, and arranged conform a cruciform for receiving a plunger shaft having a cross section as a cruciform, and arranged for receiving a plunger shaft with a cross section which is a combination of a cylindrical cross section and a cross section as a cruciform, further comprises a first and second part 2, 3 of seal 1, each part provided with at least two apertures 4, 4', 20 for receiving a grip 16 of a syringe 15, 15'.
  • the first and second part 2, 3 of seal 1 each is provided with two apertures 4, 4', 20, wherein each aperture is configured to receive a grip with a certain size and/or shape, and in combination the apertures are configured to receive various grips with varying sizes and/or shapes.
  • One aspect of the invention relates to a seal 1, 50, 60 for locking a plunger 14 of a syringe 15, 15', the seal comprising
  • the seal 1, 50, 60 comprises the first and second parts, wherein the first and second part 2, 3, 47, 46 each is provided with at least two apertures 4, 4', 20 for receiving the grip 16 of a syringe 15, 15', wherein the apertures are arranged for receiving grips with different dimensions and/or with a different shape.
  • the seal 1, 50, 60 according to the invention comprises the first and second parts, wherein the notched portion 5, 5' of the first and second part 2, 3, 47, 46 is configured for stepless receiving a plunger shaft 17, 25, 26 of the plunger 14.
  • the seal 1, 50, 60 according to the invention comprises the first and second parts 2, 3, 47, 46, wherein the first and second part each is provided with at least two apertures 4, 4', 20 for receiving the grip 16 of the syringe 15, 15'.
  • the seal 50 comprises the first and second parts, wherein the notched portions 5, 5' of said first and second parts 2, 3, 47, 46 form a circular opening 35 when the seal 50 is in the locked position, wherein the notched portions 5, 5' are arranged conform a circular shape for receiving the plunger-shaft 25 of the plunger 14 of the syringe 15'.
  • the seal 50 comprises the first and second parts, wherein each notched portion 5, 5' comprises at least two clamping pins 36, 36', 37, 37' positioned at a mutual angle of 90° such that the at least four clamping pins are respectively positioned at a mutual angle of 90° in the circular opening 35 formed by notched portions 5, 5' when the seal 50 is in the locked position.
  • the seal 60 comprises the first and second parts, wherein, wherein the notched portions 5, 5' of the first and second part 47, 46 are each provided with a notch 44, 44' and a first and second recess portion 45 in the first part 47 and a first and second recess portion 45' in the second part 46, such that each of the notches 44, 44' and opposite recess portions 45, 45' of the notched portions are arranged conform a cruciform for receiving a plunger-shaft 17, 26, when the seal 60 is in locked position.
  • the seal 1, 50, 60 comprises the first and second parts, wherein the notched portions 5, 5' of said first and second parts 2, 3, 47, 46 form a circular opening 35 when the seal 1, 50, 60 is in the locked position, wherein the notched portions 5, 5' are arranged conform a circular shape for receiving the plunger-shaft 25 of the plunger 14, and wherein the notched portions 5, 5' of the first and second part 2, 3, 47, 46 are each provided with a notch 30, 30' and a first and second recess portion 31, 32 in the first part 2, 47 and a first and second recess portion 33, 34 in the second part 3, 46, such that each of the notches 30, 30' and two opposite recess portions 31, 33 and two opposite recess portions 32, 34 of the notched portions are arranged conform a cruciform for receiving the plunger shaft, when the seal 1, 50, 60 is in locked position.
  • said seal 1, 50, 60 according to the invention comprises said lock 7 provided with said slot 7', wherein an opening 9 of the slot 7' is provided with a rim portion 10, preferably a resilient rim portion 10.
  • said rim portion 10 of the opening 9 is provided with at least one notch 11, preferably two notches 11 located at opposite sides of the rim, more preferably four notches 11 located at a mutual angle of about 90°.
  • said seal 1, 50, 60 comprises the pin 8 provided with the bulged end portion 8' in the end portion 13, wherein the bulged end portion 8' in the end portion 13 of the pin 8 is an enlarged head encompassing the end portion 13, or is a rim, or is a harpoon of a harpoon closure encompassing the end portion 13, or is the first half of a snap closure for engagement with the second half of a snap closure located in the slot 7', or is the first half of an interlocking closure for engagement with a second half of an interlocking closure located in the slot 7'.
  • said seal 1, 50, 60 according to the invention comprises the pin 8 provided with the bulged end portion 8' in the end portion 13, wherein the pin 8 is provided with a resilient bulged portion 8'.
  • said seal 1, 50, 60 comprises the pin 8, wherein the pin 8 is provided with a handle 21 arranged to release the pin 8 from the first part 2, 47 of the seal 1, 50, 60.
  • the seal 1, 50, 60 comprises at least one of a thermosetting polymer material selected from the group comprising polystyrene and polycarbonate, and/or one of a thermoplastic polymer material selected from acrylonitrile butadiene styrene and acrylonitrile styrene acrylate, preferably, the seal 1, 50, 60 is manufactured from polystyrene.
  • the seal 1, 50, 60 is manufactured from a single type of thermosetting polymer material selected from polystyrene and polycarbonate, or is manufactured from a single type of thermoplastic polymer material selected from acrylonitrile butadiene styrene and acrylonitrile styrene acrylate, preferably, the seal 1, 50, 60 is wholly manufactured from polystyrene.
  • An assembly of the invention comprises a seal 1, 50, 60 according to any of the aforementioned embodiments, in particular the indicated preferred embodiments, and a syringe 15, 15'.
  • the syringe may have a plunger shaft 17, 25, 26 having a cross sectional shape of a cylinder, or a cruciform, or a combination thereof.
  • the seal 1, 50, 60 may have one aperture 4, 4', 20 located in the two parts 2, 3 of the seal, or preferably has at least two apertures, more preferably, two apertures for receiving the syringe grip 16, 27 of syringes, said grips having sizes and shapes within certain limits, all receivable by said apertures.
  • the seal of the assembly of the invention comprises a lock comprising a pin 8 provided with a handle 21 arranged to release the pin 8 from the first part 2 of the seal 1, 50, 60 by tearing or breaking a removable seal 12, e.g. by turning the handle 21 along the longitudinal axis of the pin 8.
  • the syringe 15, 15' is preferably provided with a needle, which needle is preferably a luer-lock type of needle with regard to the attachment means for attaching the needle to the nozzle of the syringe, i.e. the syringe barrel.
  • the needle is provided with a cap, which is a releasable cap.
  • Such cap has various functions. First, the cap closes the end portion of the needle exposed to the surrounding, thereby preventing the entrance of any substances or microbes from the surrounding into the needle and thus into the syringe barrel, and thereby preventing the liquid contained in the syringe from being released. Second, the cap prevents against possible injuries imposed by the needle.
  • a prefilled syringe can be supplied with a largely reduced risk for contamination of the liquid medicament contained by the syringe, and with a largely reduced risk for reduction of volume and quality of the liquid medicament, while at the same time the assembly of the invention provides for a ready to use prefilled syringe which is provided with a tamper proof seal further improving the safe and efficacious application of the medicament contained in the prefilled syringe.
  • a syringe 15, 15' is provided with a seal 1, 50, 60 of the invention.
  • the syringe is a prefilled syringe.
  • the prefilled syringe is prefilled with a liquid medicament, such as a medicament which is relatively expensive, and/or which is difficult to manufacture, and/or which is scarce, and/or which should be administered to a subject such as a human patient at a dose and volume within relatively narrow limits, and/or which is susceptible for decay, chemical modification, etc., upon exposure to air, needle material, etc.
  • the liquid medicament is an aqueous pharmaceutical composition, comprising at least one active pharmaceutical ingredient.
  • the syringe provided with a seal 1, 50, 60 of the invention, and the syringe comprised by the assembly 22, 23, 24 of the invention is typically a syringe meant for single use, such as a disposable syringe, although the single use syringe also can be a reusable syringe, according to the invention.
  • the seal 1, 50, 60 of the invention immobilizes the plunger 14 of a syringe 15, 15'relative to the syringe barrel 18, when in locked position, the syringe is conveniently provided with a (capped) needle.
  • a cap Currently, prefilled syringes are commonly provided with a cap, without a needle, which is a requirement since the plunger is not conveniently fixated at a predetermined position in the syringe barrel upon application of currently available seals.
  • an assembly 22, 23, 24 is provided comprising the seal 1, 50, 60 according to the invention and a syringe 15, 15' comprising a plunger 14 locked by said seal at a selected position such as for example a predetermined position 17' in the barrel 18 of said syringe, wherein the plunger shaft 25, 26 is essentially cylindrically shaped or the plunger shaft 17 is formed as a cruciform, or a combination thereof.
  • the syringe is a prefilled syringe filled with a liquid such as a liquid medicament, wherein the volume of the liquid preferably equals a single unit dose, and wherein preferably the prefilled syringe is provided with a luer-locked needle.
  • a mold is provided for molding the two parts 2, 3 of the seal 1, 50, 60 of the invention, which two parts are hinged by a hinge 6, wherein the mold is for manufacturing said two hinged parts 2, 3.
  • the two parts 2, 3 are molded separately in two separate molds.
  • the parts 2, 3 are molded by applying injection molding.
  • the two parts 2, 3 are molded upon application of a single polymer, preferably polystyrene.
  • the parts 2, 3 of the seal 1, 50, 60 of the invention are molded, e.g. in two separate molds, wherein the parts are wholly made of polystyrene.
  • a computer readable medium of the invention comprising computer executable instructions and 3D data representing the seal 1, 50, 60 of the invention, which computer executable instructions and 3D data representing the seal 1, 50, 60, when loaded on a computer system connected to a 3D printer, allows to 3D print the two parts 2, 3, 47, 46 of the seal 1, 50, 60.
  • a computer system comprising a processor, a memory and a 3D printer, which processor is arranged to execute instructions, stored in said memory, for 3D printing of the two parts 2, 3 of the seal 1, 50, 60 of the invention by said 3D printer.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
EP17199879.2A 2017-11-03 2017-11-03 Dichtung zum verriegeln einer spritze Withdrawn EP3479857A1 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP17199879.2A EP3479857A1 (de) 2017-11-03 2017-11-03 Dichtung zum verriegeln einer spritze
EP18793679.4A EP3703793A1 (de) 2017-11-03 2018-11-02 Dichtung zum verriegeln einer spritze
PCT/EP2018/079978 WO2019086590A1 (en) 2017-11-03 2018-11-02 Seal for locking a syringe

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17199879.2A EP3479857A1 (de) 2017-11-03 2017-11-03 Dichtung zum verriegeln einer spritze

Publications (1)

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EP3479857A1 true EP3479857A1 (de) 2019-05-08

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EP17199879.2A Withdrawn EP3479857A1 (de) 2017-11-03 2017-11-03 Dichtung zum verriegeln einer spritze
EP18793679.4A Withdrawn EP3703793A1 (de) 2017-11-03 2018-11-02 Dichtung zum verriegeln einer spritze

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001023017A2 (en) 1999-09-28 2001-04-05 Virginia Dutton Syringe plunger immobilizing device
GB2377176A (en) 2001-06-30 2003-01-08 John Leyshon Maddocks A device for controlling the administration of material, such as medicine
WO2005089840A1 (fr) * 2004-02-24 2005-09-29 Biocorp Recherche Et Developpement Dispositif d'inviolabilite pour seringue et seringue equipee d'un tel dispositif
NL1038569C2 (nl) 2011-02-08 2012-08-09 Jan Willem Popma Uit een of meerdere delen bestaande en op diverse plaatsen ingesneden klem welke uit kunststof, metaal of ander materiaal vervaardigd is en die aan de rand op de achterzijde van de veelal voor medische doeleinden toegepaste spuit bevestigd wordt en welke door de bevestiging te sluiten de plunjer fixeert in de gekozen stand.
WO2015045180A1 (ja) * 2013-09-30 2015-04-02 テルモ・クリニカルサプライ株式会社 医療用吸引具

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001023017A2 (en) 1999-09-28 2001-04-05 Virginia Dutton Syringe plunger immobilizing device
GB2377176A (en) 2001-06-30 2003-01-08 John Leyshon Maddocks A device for controlling the administration of material, such as medicine
WO2005089840A1 (fr) * 2004-02-24 2005-09-29 Biocorp Recherche Et Developpement Dispositif d'inviolabilite pour seringue et seringue equipee d'un tel dispositif
NL1038569C2 (nl) 2011-02-08 2012-08-09 Jan Willem Popma Uit een of meerdere delen bestaande en op diverse plaatsen ingesneden klem welke uit kunststof, metaal of ander materiaal vervaardigd is en die aan de rand op de achterzijde van de veelal voor medische doeleinden toegepaste spuit bevestigd wordt en welke door de bevestiging te sluiten de plunjer fixeert in de gekozen stand.
WO2015045180A1 (ja) * 2013-09-30 2015-04-02 テルモ・クリニカルサプライ株式会社 医療用吸引具

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Publication number Publication date
WO2019086590A1 (en) 2019-05-09
EP3703793A1 (de) 2020-09-09

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