EP3456336B8 - A celery seed and sophora flower bud extract and medical use thereof - Google Patents

A celery seed and sophora flower bud extract and medical use thereof Download PDF

Info

Publication number
EP3456336B8
EP3456336B8 EP17795603.4A EP17795603A EP3456336B8 EP 3456336 B8 EP3456336 B8 EP 3456336B8 EP 17795603 A EP17795603 A EP 17795603A EP 3456336 B8 EP3456336 B8 EP 3456336B8
Authority
EP
European Patent Office
Prior art keywords
medical use
flower bud
sophora flower
celery seed
bud extract
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP17795603.4A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP3456336A4 (en
EP3456336B1 (en
EP3456336A1 (en
Inventor
Yongliang GAO
Guimin ZHANG
Qingwei Jiang
Qiang Zhang
Hua Qin
Yuan DI
Weifeng Yi
Baochuan LIU
Changhong Chen
Hongqian JIA
Tiejun Zhang
Wenbin Yang
Jiangtao CUI
Bo Li
Huangyan WU
Haisheng Chen
Jianning Sun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Tianheng Junwei Pharmaceutical Tech Co Ltd
Original Assignee
Beijing Tianheng Junwei Pharmaceutical Tech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Tianheng Junwei Pharmaceutical Tech Co Ltd filed Critical Beijing Tianheng Junwei Pharmaceutical Tech Co Ltd
Publication of EP3456336A1 publication Critical patent/EP3456336A1/en
Publication of EP3456336A4 publication Critical patent/EP3456336A4/en
Application granted granted Critical
Publication of EP3456336B1 publication Critical patent/EP3456336B1/en
Publication of EP3456336B8 publication Critical patent/EP3456336B8/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Botany (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP17795603.4A 2016-05-12 2017-05-12 A celery seed and sophora flower bud extract and medical use thereof Active EP3456336B8 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610313303.8A CN107362194B (zh) 2016-05-12 2016-05-12 复方芹菜籽槐米提取物及其医药用途
PCT/CN2017/084073 WO2017193985A1 (zh) 2016-05-12 2017-05-12 复方芹菜籽槐米提取物及其医药用途

Publications (4)

Publication Number Publication Date
EP3456336A1 EP3456336A1 (en) 2019-03-20
EP3456336A4 EP3456336A4 (en) 2019-11-06
EP3456336B1 EP3456336B1 (en) 2021-07-21
EP3456336B8 true EP3456336B8 (en) 2021-10-06

Family

ID=60266289

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17795603.4A Active EP3456336B8 (en) 2016-05-12 2017-05-12 A celery seed and sophora flower bud extract and medical use thereof

Country Status (5)

Country Link
EP (1) EP3456336B8 (ja)
JP (1) JP6818972B2 (ja)
KR (2) KR20190003736A (ja)
CN (1) CN107362194B (ja)
WO (1) WO2017193985A1 (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111529597A (zh) * 2020-05-29 2020-08-14 广东众益康生物科技有限公司 一种用于痛风和/或高尿酸血症的中药组合物
CN115120631B (zh) * 2021-03-26 2024-04-23 北京天衡军威医药技术开发有限公司 一种治疗痛风及高尿酸血症的药物组合物及其制备方法
CN113384607B (zh) * 2021-06-30 2022-06-24 北京劲得健康科技有限公司 芹菜籽提取物及其在抗高尿酸血症和抗痛风产品中的应用
CN115607588B (zh) * 2021-07-13 2023-11-17 北京天衡军威医药技术开发有限公司 一种标本兼治抗痛风的芹槐提取物与非布司他药物组合物及其用途
KR102507494B1 (ko) 2021-09-10 2023-03-13 경북대학교 산학협력단 샐러리씨 추출물을 유효성분으로 포함하는 근력 약화 관련 질환 예방, 개선 또는 치료용 조성물
WO2023038287A1 (ko) * 2021-09-10 2023-03-16 경북대학교 산학협력단 샐러리씨 추출물을 유효성분으로 포함하는 근력 약화 관련 질환 예방, 개선 또는 치료용 조성물
FR3134820A1 (fr) * 2022-04-20 2023-10-27 L'oreal Concrete et absolue de parfum obtenues par extraction de solvant (poly)ol organique a partir de matieres naturelles solides
CN115299602A (zh) * 2022-06-29 2022-11-08 北京彩晔健康管理有限公司 一种降尿酸组合物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100569241C (zh) 2007-01-17 2009-12-16 北京天川军威医药技术开发有限公司 芹菜籽乙酸乙酯萃取物及其用途
CN101181345B (zh) * 2007-11-15 2011-01-12 南京大学 槐米黄酮提取物在制备尿酸转运子urat1抑制药物中的应用
CN102008525B (zh) * 2010-12-09 2012-11-28 北京人福军威医药技术开发有限公司 芹菜籽提取物的微丸及其制备方法
CN102048775B (zh) * 2010-12-09 2012-11-07 北京人福军威医药技术开发有限公司 芹菜籽提取物的组合物及其制备方法
CN103947948B (zh) * 2014-03-19 2015-12-30 桂玉平 一种槐花保健米糕及其加工方法
CN105535048A (zh) * 2016-01-04 2016-05-04 中国科学院昆明植物研究所 芹菜籽提取物在制备抗高尿酸血症和抗痛风的药物或保健食品中的应用

Also Published As

Publication number Publication date
JP2019515050A (ja) 2019-06-06
EP3456336A4 (en) 2019-11-06
EP3456336B1 (en) 2021-07-21
JP6818972B2 (ja) 2021-01-27
CN107362194B (zh) 2020-08-25
KR20200142107A (ko) 2020-12-21
WO2017193985A1 (zh) 2017-11-16
CN107362194A (zh) 2017-11-21
KR102331984B1 (ko) 2021-12-02
KR20190003736A (ko) 2019-01-09
EP3456336A1 (en) 2019-03-20

Similar Documents

Publication Publication Date Title
EP3456336B8 (en) A celery seed and sophora flower bud extract and medical use thereof
EP3606400A4 (en) ORIENTATION OF A PATIENT INSERTION DEVICE
EP3463072A4 (en) SURGICAL MAGNETOMETER.
EP3256049A4 (en) Devices for integrated indirect sweat stimulation and sensing
EP3217778A4 (en) Seed planting apparatus, systems and methods
EP3271784A4 (en) Localization and mapping using physical features
EP3285851A4 (en) A microneedle and a chip
EP3286297A4 (en) Devices for simulating a function of a tissue and methods of use and manufacturing thereof
EP3395162A4 (en) TRANSPLANTATION DEVICE AND TRANSPLANTATION METHOD
EP3646883A4 (en) NEW TUMOR VACCINE AND ITS USE
EP3231364A4 (en) Bioelectrode and garment
EP3733663A4 (en) QUINAZOLINE DERIVATIVE AND ITS USE
EP3162341A4 (en) Absorbent article and wearable article including absorbent article
EP3192553A4 (en) Brain retraction device and surgical retraction device
EP3095317A4 (en) Planting unit and planter
EP3145416A4 (en) A non-reusable intra-osseous access device and method thereof
EP3182905A4 (en) Implant positioning devices and methods
EP3162343A4 (en) Absorbent article and wearable article including absorbent article
EP3261701A4 (en) Pressure-sensing catheters and related methods
EP3153529A4 (en) Water-absorbing resin and absorbent article
EP3137147A4 (en) Catheter instrument and catheter hub therefore
EP3558143A4 (en) TISSUE EXTRACTION DEVICES AND RELATED PROCESSES
EP3168241A4 (en) Water-absorbing resin and absorbent article
EP3445431A4 (en) PATIENT INTERFACE AND ASPECTS THEREOF
EP3212283A4 (en) Adjustable headpiece with anatomical markers and methods of use thereof

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20181127

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20191008

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 36/489 20060101AFI20191001BHEP

Ipc: A61K 36/23 20060101ALI20191001BHEP

Ipc: A61P 19/06 20060101ALI20191001BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20201126

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20210316

RIN1 Information on inventor provided before grant (corrected)

Inventor name: SUN, YUNXIA

Inventor name: ZHAO, JING

Inventor name: WANG, HUIXIA

Inventor name: WANG, XUEZHI

Inventor name: ZUO, CONGLIN

Inventor name: LIU, WEIXIN

Inventor name: LIN, ZHIJIAN

Inventor name: LU, YANWEI

Inventor name: SUN, JIANNING

Inventor name: CHEN, HAISHENG

Inventor name: ZHANG, BING

Inventor name: GAO, YONGLIANG

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

RAP3 Party data changed (applicant data changed or rights of an application transferred)

Owner name: BEIJING TIANHENG JUNWEI PHARMACEUTICAL TECH CO., LTD

RIN1 Information on inventor provided before grant (corrected)

Inventor name: SUN, JIANNING

Inventor name: CHEN, HAISHENG

Inventor name: WU, HUANGYAN

Inventor name: LI, BO

Inventor name: CUI, JIANGTAO

Inventor name: YANG, WENBIN

Inventor name: ZHANG, TIEJUN

Inventor name: JIA, HONGQIAN

Inventor name: CHEN, CHANGHONG

Inventor name: LIU, BAOCHUAN

Inventor name: YI, WEIFENG

Inventor name: DI, YUAN

Inventor name: QIN, HUA

Inventor name: ZHANG, QIANG

Inventor name: JIANG, QINGWEI

Inventor name: ZHANG, GUIMIN

Inventor name: GAO, YONGLIANG

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602017042574

Country of ref document: DE

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 1411970

Country of ref document: AT

Kind code of ref document: T

Effective date: 20210815

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: PK

Free format text: BERICHTIGUNG B8

Ref country code: CH

Ref legal event code: PK

Free format text: TITEL

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG9D

REG Reference to a national code

Ref country code: NL

Ref legal event code: MP

Effective date: 20210721

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 1411970

Country of ref document: AT

Kind code of ref document: T

Effective date: 20210721

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210721

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210721

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211021

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210721

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210721

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211122

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211021

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210721

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210721

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210721

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210721

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210721

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210721

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211022

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602017042574

Country of ref document: DE

REG Reference to a national code

Ref country code: DE

Ref legal event code: R082

Ref document number: 602017042574

Country of ref document: DE

Representative=s name: PATENTANWAELTE ISENBRUCK BOESL HOERSCHLER PART, DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210721

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210721

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210721

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210721

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210721

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210721

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210721

26N No opposition filed

Effective date: 20220422

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20220531

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210721

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220512

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220531

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220531

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220512

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220531

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20170512

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210721

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210721

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210721

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20240516

Year of fee payment: 8

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20240527

Year of fee payment: 8

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20240522

Year of fee payment: 8

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210721

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20240529

Year of fee payment: 8