EP3411464B1 - Detergent compositions for cleaning in the cosmetic and pharmaceutical industry - Google Patents

Description

The present invention relates to the use of detergent compositions for cleaning manufacturing equipment, packaging or any other equipment used in the manufacture or packaging of hydrophobic cosmetic or pharmaceutical preparations. The invention also relates to such detergent compositions as such.

Manufacturing and packaging equipment as well as any other equipment used in the manufacture and packaging of cosmetic and pharmaceutical products are generally cleaned using a dynamic system with turbulence. These dynamic systems include in particular "cleaning in place" (CIP, in English "clean in place" or CIP), soaking with strong agitation, washing in a closed circuit via washing balls, cleaning in washer and cleaning in washing cabin.

These cleaning systems require specific non-foaming detergents to prevent the formation of foam due to the turbulence created in the system. These detergents are generally strongly alkaline and therefore contain significant amounts of alkali hydroxide as well as surfactants and sequestering and antiflocculation agents.

The European patent application EP 1,200,544 describes for example an alkaline detergent for the elimination of residues containing pigments appearing during the manufacture or packaging of pharmaceutical or cosmetic products. This detergent contains surfactants, in particular nonionic such as alkoxylated fatty alcohols, alkylpolyglucosides and / or alkoxylated fatty amines, and a combination of polyaspartic acid and gluconic acid or of their salts as complexing agents. However, this detergent does not allow the removal of highly hydrophobic residues from production and packaging facilities. which represents a major drawback today due to the fact that cosmetic products such as for example foundations, mascaras, lipsticks are more and more hydrophobic and rich in pigments, in particular in oxides such as for example in titanium oxide.

Of the document WO 99/53003 A1 , a detergent composition is known for removing stains of oxidized grease adhering to the surfaces of floors, walls and kitchen implements containing a nonionic surfactant based on an amine oxide. This document teaches that the amine oxide improves the detergent power and at the same time acts as a solubilizing agent for the water-insoluble organic solvent also contained in the detergent composition. However, this document also teaches that when the content of the amine oxide surfactant is less than 20% by weight, the detergency is insufficient to remove stains of oxidized fat or persistent stains of denatured fat.

There is therefore a need for new detergents making it possible to effectively clean very hydrophobic residues, containing or not containing pigments, encountered during the manufacture of cosmetic and pharmaceutical products.

The Applicant deserves credit for having developed, as a result of a great deal of research, a new detergent composition meeting these requirements.

It is to the Applicant's merit to have found that these drawbacks could be overcome by using a detergent composition which is based on the combination of a non-ionic surfactant, a co-surfactant and a specifically chosen organic alkaline agent. for its ability to effectively remove a wide range of hydrophobic residues typically encountered in the manufacture and packaging of cosmetic and pharmaceutical preparations. These residues can for example be finished products, such as foundations, sunscreens, lipsticks, mascaras, toothpastes, etc., semi-finished products such as bases for foundation, creams, etc. or raw materials such as for example gels and silicones, volatile or not, containing modified clays such as hectorite and its derivatives.

• un tensioactif non ionique choisi parmi les alcools gras alcoxylés,
• un co-tensioactif non aromatique choisi parmi les amine-oxydes, les alkylsulfates et les alkylsulfonates, et
• un agent alcalin organique choisi parmi les aminoalcools, à l'exclusion de la monoéthanolamine,

le tensioactif non-ionique étant un mélange d'alcools gras alcoxylés contenant des alcools gras éthoxylés, propoxylés et butoxylés, et la teneur en co-tensioactif non aromatique étant contenu dans la composition détergente dans une quantité de 1 à 15 % en poids par rapport au poids total de la composition.The invention therefore relates to the use of a detergent composition for the removal of hydrophobic residues, whether or not containing pigments, from the surfaces of manufacturing equipment, packaging or any other material used in the manufacture or packaging of cosmetic or pharmaceutical preparations, said detergent composition comprising:

• a nonionic surfactant chosen from alkoxylated fatty alcohols,
• a non-aromatic co-surfactant chosen from amine-oxides, alkylsulphates and alkylsulphonates, and
• an organic alkaline agent chosen from aminoalcohols, excluding monoethanolamine,

the nonionic surfactant being a mixture of alkoxylated fatty alcohols containing ethoxylated, propoxylated and butoxylated fatty alcohols, and the content of non-aromatic co-surfactant being contained in the detergent composition in an amount of 1 to 15% by weight relative to the total weight of the composition.

This specific combination of a nonionic surfactant, a co-surfactant and an organic alkaline agent makes it possible to effectively remove even extremely hydrophobic residues, containing or not containing pigments, from manufacturing and packaging facilities. as well as any other material used in the manufacture or packaging of cosmetic or pharmaceutical preparations. These other materials include in particular stainless steel buckets, spatulas, transfer and suction pipes, transfer and suction pumps, dosing nozzles, filling nozzles for packaging lines.

Unlike the detergents used in the state of the art, the use according to the invention of a detergent based on this combination specific removes a wide range of different residues such as foundation, lipsticks, waterproof mascaras, toothpastes, extremely hydrophobic raw materials containing pigments such as for example modified clays such as hectorite and its derivatives, in particular bentones.

The alkoxylated nonionic surfactant chosen from alkoxylated fatty alcohols is a mixture of several alkoxylated fatty alcohols. Such a mixture contains ethoxylated, propoxylated, butoxylated and optionally pentoxylated fatty alcohols. Preferably, the alkoxylated fatty alcohol (s) are alkoxylated branched C5 to C11 fatty alcohols. Thus, a preferred nonionic surfactant of the invention contains a mixture of ethoxylated, propoxylated, butoxylated and optionally pentoxylated branched C5 to C11 fatty alcohols. In this type of surfactant, the short branched chain confers a high critical micellar concentration (CMC), thus limiting the formation of micelles at low doses (availability of surfactants for detergency), the hydrophilic part, composed of d oxide units. ethylene, propyelene oxide and in particular butylene oxide, and optionally pentylene oxide, gives the surfactant a very pronounced antifoaming effect. In addition, the steric hindrance resulting from the presence of butylene oxide contributes to stabilizing this surfactant in an acaline medium. These surfactants combine a high wetting power with a very low foaming effect and are also biodegradable. Examples of nonionic surfactants which are particularly suitable for the present invention are the alkoxylated fatty alcohols sold by the company BASF (Ludwigshafen, Germany) under the name Plurafac® LF, in particular Plurafac® LF 305, Plurafac® LF 120 and Plurafac® LF 711.

The alkoxylated nonionic surfactant is advantageously contained in the detergent composition in an amount of 3 to 20%, preferably 5 to 15%, more preferably 5 to 10% and more preferably still about 10% by weight relative to the total weight of the composition.

The non-aromatic co-surfactant is chosen from amine-oxides, alkylsulphates and alkylsulphonates. The amine oxides include in particular C10 to C16 alkyl dimethyl amine oxides. A preferred amine oxide is N, N-dimethyl decyl amine oxide, sold for example under the name Ammonyx® DO40 by the company Stepan (Stepan Europe, Voreppe, France). For the alkylsulphates and alkylsulphonates, they may in particular be sodium, potassium or ammonium, preferably sodium, sulphates and sulphonates. Alkyl sulphates include in particular C 6 to C 10 alkyl sulphates. A preferred alkylsulfate is 2-ethylhexylsulfate, sold under the name EMPICOL® 0585 / U (Huntsman). Alkylsulfonates include in particular C6 to C8 alkylsulfonates. An example of such a commercial alkylsulfonate is BIO-TERGE® PAS-7S marketed by the company Stepan (Stepan Europe, Voreppe, France).

The non-aromatic co-surfactant is contained in the detergent composition in an amount of 1 to 15%, preferably 3 to 10%, more preferably 3 to 6% and more preferably still about 6% by weight relative to the total weight of the composition.

The use of an organic alkaline agent chosen from amino alcohols, excluding monoethanolamine, has the advantage of providing a reserve of alkalinity without damaging materials sensitive to corrosion or exhibiting a strong tendency to carbonation. . Preferably, chosen from triethanolamine and 2-amino-2-methyl-1-propanol, more preferably the aminoalcohol is triethanolamine.

The organic alkaline agent chosen from amino alcohols is advantageously contained in the detergent composition in an amount of 5 to 50%, preferably 10 to 40% and more preferably still from 15 to 30% by weight relative to the total weight of the product. composition.

The detergent composition used in accordance with the invention may further comprise an aromatic hydrotrope. This hydrotropic agent aromatic can for example be chosen from xylenesulphonates, toluenesulphonates and cumenesulphonates. They can in particular be sodium, potassium or ammonium sulphonates, preferably sodium. Xylenesulphonates being preferred since they make it possible to monitor the concentration of the detergent, in particular in the rinsing water, by HPLC. Those skilled in the art will know how to adapt the amount of aromatic hydrotrope as a function in particular of the amounts of organic alkaline agent and of alkoxylated nonionic surfactants employed.

The detergent composition used in accordance with the invention may further comprise an alkali hydroxide. Preferably, the detergent composition comprises less than 5%, more preferably less than 3% and more preferably still less than 2% by weight of alkali hydroxide relative to the total weight of the detergent composition. The alkaline hydroxide can in particular be chosen from sodium hydroxide and potassium hydroxide.

The detergent composition used in accordance with the invention may further comprise other adjuvants such as, for example, third solvents, such as propylene glycol or ethylene glycol, and / or antiflocculant agents. The antiflocculant agents can for example be phosphonic acids and their alkali metal salts (phosphonates), such as, for example, 1-hydroxy-ethane-1,1-diphosphonic acid, aminotrismethylene-phosphonic acid, ethylenediaminotetramethylene-phosphonic acid, phosphonobutanetricarboxylic acid, diethylenetriamine penta (methylene phosphonic acid; or homo-, co- or terpolymers based on acrylic acid or alkali metal salts thereof (polyacrylates).

The ready-to-use detergent composition generally has a pH of 7 to 13, preferably 8 to 12.

In a particular embodiment, the detergent composition contains neither polyaspartic acid nor gluconic acid or one of their salts.

In the use according to the invention, the detergent composition is advantageously used at a temperature of 40 to 85 ° C, preferably from 55 to 70 ° C, more preferably from 60 to 70 ° C and more preferably around 65 ° C.

According to a preferred embodiment of the use according to the invention, the detergent composition is used in a dynamic cleaning system with turbulence. Advantageously, the dynamic cleaning system with turbulence is chosen from cleaning in place, soaking with agitation, washing in a closed circuit via washing balls, cleaning in a washer and cleaning in the washing cabin.

The present invention also relates to the detergent composition used in the use according to the invention as described above. This composition may be in the form of a concentrate to be diluted with water, preferably softened, demineralized or osmosed, before use or in the form of a ready-to-use solution.

The invention will now be described with the aid of non-limiting examples of embodiment of the invention.

FIGURES

• Figure 1 : Photos of tinted moisturizer residue - dry skin before and after the performance test with KOPHANIOS CIP MAXI PP (Laboratoires Anios) and composition C7 according to the invention.
• Figure 2 : Photos of lipstick residues before and after the performance test with KOPHANIOS CIP MAXI PP (Laboratoires Anios) and composition C7 according to the invention.
• Figure 3 : Photos of black waterproof mascara residue before and after the performance test with the KOPHANIOS CIP MAXI PP (Laboratoires Anios) and the composition C7 according to the invention.

Figure 4 : Photos of whitening toothpaste residues before and after the performance test with KOPHANIOS CIP MAXI PP (Laboratoires Anios) and composition C7 according to the invention.

EXAMPLES

Several detergent compositions have been evaluated for their ability to remove various residues typically encountered in the manufacture of cosmetic products.

A. Detergent compositions tested A.1. Compositions with amine oxide

Nine detergent compositions, six of which according to the invention (C4 to C9) were prepared and tested. Two compositions of the state of the art were also tested.

Table 1 gives the composition of nine of these compositions, the other two compositions were respectively KOPHANIOS CIP MAXI PP (Laboratoires Anios, Hellemmes, France) and the detergent of Example 3 of the patent application EP 1,200,544 . Composition (% by weight / total weight) C1 C2 C3 C4 C5 C6 C7 C8 C9 Demineralized Water qsp Plurafac LF 305 (alkoxylated fatty alcohol) 0 10 10 5 10 10 10 10 10 Ammonyx® DO 40 (co-surfactant) 6 0 6 6 3 6 6 1 15 Triethanolamine 30 30 0 30 30 15 30 30 30 NaOH 1.5 Sodium xylenesulfonate 6 Diproplyleneglycolbutoxyether 10 Dequest 2066 (DTPMP) 0.125

A.2. Compositions with alkylsulfate or alkylsulfonate

Nine detergent compositions (C10 to C18) including six according to the invention (C14 to C18) in which the co-surfactant is an alkylsulfate or an alkylsulfonate were prepared. Table 2 gives the composition of each of these compositions. <b> Table 2 </b> Composition (% by weight / total weight) C10 C11 C12 C13 C14 C15 C16 C17 C18 Demineralized Water Qsp Plurafac LF 305 (alkoxylated fatty alcohol) 0 0 10 10 5 10 10 10 10 2-ethylhexylsulfate 6 6 3 6 Sodium Alkane Sulfonate 6 6 6 3 6 Triethanolamine 30 30 0 0 30 30 30 30 30 NaOH 1.5 Sodium xylenesulfonate 6 Diproplylene glycol butoxyether 10 Dequest 2066 (DTPMP) 0.125

B. Performance tests 1) Test protocol

These performance tests were carried out according to the following test protocol with compositions C1 to C19, Kophanios CIP MAXI PP (KCMPP) and the detergent of Example 3 of the patent application EP 1,200,544 , diluted to 5% v / v in softened water.

1. 1) Dépôt d'une couche uniforme du produit à éliminer sur les parois interne du bécher.
2. 2) Séchage à air ambiant pendant 10 minutes.
3. 3) Remplissage au trois quart du bécher avec la solution détergente à tester.
4. 4) Mise sous agitation de la solution à l'aide d'un barreau aimanté sur agitateur magnétique à une température de 65 ± 5°C pendant 30 min.

Support: 316 L grade stainless steel beakers with a volume of 200 mL.

1. 1) Deposit of a uniform layer of the product to be eliminated on the internal walls of the beaker.
2. 2) Dry in ambient air for 10 minutes.
3. 3) Three quarters full of the beaker with the detergent solution to be tested.
4. 4) Stirring of the solution using a bar magnet on a magnetic stirrer at a temperature of 65 ± 5 ° C for 30 min.

The detergency is quantified by visual assessment (remaining product, traces, shine, etc.).

2) Test results

The performance tests have clearly demonstrated that only detergent compositions containing the specific combination of a nonionic surfactant, a co-surfactant and an organic alkaline agent make it possible to remove all the residues tested in a satisfactory manner. Tables 3 and 4 below summarize the results. <b> Table 3 </b> Cosmetic product C1 C2 C3 C4 C5 C6 C7 C8 C9 KOPHANIOS CIP MAXI PP EP1200544 - Ex. 3 Tinted moisturizer - dry skin - - + + + ++ ++ + ++ - + Lipstick - - + + + ++ ++ + ++ - - Face powder - - + + + ++ ++ + ++ - born Black waterproof mascara - - + + ++ ++ ++ + ++ - born Whitening toothpaste - - + + + ++ ++ ++ ++ + born Bentone Gel VS-5V - + - + ++ + ++ ++ ++ - - Cosmetic product C10 C11 C12 C13 C14 C15 C16 C17 C18 Tinted moisturizer - dry skin - - + + + - - ++ ++ Lipstick - - + + + + + + ++ Face powder - - + + + + + ++ ++ Black waterproof mascara - - - - + + + + + Whitening toothpaste - - + + + + + ++ ++ Bentone Gel VS-5V - - - - + ++ + ++ + -: lack of efficacy, practically all the residue remains
-: slight detergency, no significant effect
+: correct detergency but presence of some traces or a slight dull veil on the stainless steel surface,
++: good detergent effect, no dull haze and shiny stainless steel surface
ne: not evaluated

The photos reproduced in figures 1 to 4 show the superior cleaning performance of composition C7 compared to KOPHANIOS CIP MAXI PP. Composition C7 is clearly more efficient than the reference product KOPHANIOS CIP MAXI PP on all the residues tested and composition C9 shows performances of the same level as those of composition C7.

Claims (15)

1. Use of a detergent composition for eliminating hydrophobic residues, optionally containing pigments, from manufacturing equipment, packaging or any other material used for manufacturing or packaging cosmetic or pharmaceutical preparations, said detergent composition comprising
   alcohols

   - a non-aromatic cosurfactant chosen from amine oxides, alkyl sulfates and alkyl sulfonates, and

   - an organic alkaline agent chosen from amino alcohols, excluding monoethanolamine,

   the nonionic surfactant being a mixture of alkoxylated fatty alcohols containing ethoxylated, propoxylated and butoxylated fatty alcohols, and the non-aromatic cosurfactant content being contained in the detergent composition in a quantity of from 1% to 15% by weight with respect to the total weight of the composition.
2. Use according to claim 1, characterised in that the nonionic surfactant is a mixture of alkoxylated fatty alcohols containing ethoxylated, propoxylated, butoxylated and pentoxylated fatty alcohols.
3. Use according to claim 1 or 2, characterised in that the non-aromatic cosurfactant is an amine oxide, preferably a C10 to C16 N,N-dimethylalkylamine oxide, more preferentially N,N-dimethyldecylamine oxide.
4. Use according to any one of claims 1 to 3, characterised in that the organic alkaline agent chosen from amino alcohols is triethanolamine.
5. Use according to any one of claims 1 to 4, characterised in that the detergent composition further comprises an aromatic hydrotrope.
6. Use according to any one of claims 1 to 5, characterised in that the detergent composition comprises less than 5% by weight alkaline hydroxide with respect to the total weight of the detergent composition.
7. Use according to any one of claims 1 to 6, characterised in that the detergent composition is used at a temperature of 40° to 85°C.
8. Use according to any one of claims 1 to 7, wherein the detergent composition is used in a dynamic cleaning system with turbulence.
9. Use according to claim 8, wherein the dynamic cleaning system with turbulence is chosen from cleaning in place, soaking with stirring, washing in closed circuit via washing balls, cleaning in a washer and cleaning in a washing booth.
10. Detergent composition comprising:

    - a nonionic surfactant chosen from alkoxylated fatty alcohols,

    - a non-aromatic cosurfactant chosen from amine oxides, alkyl sulfates and alkyl sulfonates, and

    - an organic alkaline agent chosen from amino alcohols, excluding monoethanolamine,

    the nonionic surfactant being a mixture of alkoxylated fatty alcohols containing ethoxylated, propoxylated and butoxylated fatty alcohols, and the non-aromatic cosurfactant content being contained in the detergent composition in a quantity of from 1% to 15% by weight with respect to the total weight of the composition.
11. Detergent composition according to claim 10, characterised in that the nonionic surfactant is a mixture of alkoxylated fatty alcohols containing ethoxylated, propoxylated, butoxylated and pentoxylated fatty alcohols.
12. Composition according to claim 10, characterised in that the non-aromatic cosurfactant is an amino oxide, preferably a C10 to C16 N,N-dimethylalkylamine oxide, more preferentially N,N-dimethyldecylamine oxide.
13. Composition according to any one of claims 10 to 12, characterised in that the organic alkaline agent chosen from amino alcohols is triethanolamine.
14. Composition according to any one of claims 10 to 13, characterised in that the detergent composition further comprises an aromatic hydrotrope.
15. Composition according to any one of claims 10 to 14, characterised in that the detergent composition comprises less than 5% by weight alkaline hydroxide with respect to the total weight of the detergent composition.

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