EP3332807A3 - Verwendung von anti il-1-beta-antikörpern - Google Patents

Verwendung von anti il-1-beta-antikörpern Download PDF

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Publication number
EP3332807A3
EP3332807A3 EP17199544.2A EP17199544A EP3332807A3 EP 3332807 A3 EP3332807 A3 EP 3332807A3 EP 17199544 A EP17199544 A EP 17199544A EP 3332807 A3 EP3332807 A3 EP 3332807A3
Authority
EP
European Patent Office
Prior art keywords
compounds
receptor
rheumatoid arthritis
antibodies
ligand
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP17199544.2A
Other languages
English (en)
French (fr)
Other versions
EP3332807B1 (de
EP3332807A2 (de
Inventor
Phil Lowe
Hermann Gram
Thomas Jung
Timothy Wright
Trevor Mundel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37806690&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP3332807(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Priority to EP23155348.8A priority Critical patent/EP4218815A3/de
Publication of EP3332807A2 publication Critical patent/EP3332807A2/de
Publication of EP3332807A3 publication Critical patent/EP3332807A3/de
Application granted granted Critical
Publication of EP3332807B1 publication Critical patent/EP3332807B1/de
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/246—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
EP17199544.2A 2005-10-26 2006-10-24 Verwendung von anti il-1-beta-antikörpern Active EP3332807B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP23155348.8A EP4218815A3 (de) 2005-10-26 2006-10-24 Verwendung von anti il-1-beta-antikörpern

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US73043505P 2005-10-26 2005-10-26
US74212505P 2005-12-02 2005-12-02
EP10181100A EP2332577A1 (de) 2005-10-26 2006-10-24 Neuartige Verwendung von IL-1beta-Verbindungen
EP06826560A EP1940465B1 (de) 2005-10-26 2006-10-24 Neue verwendung von anti il-1-beta-antikörpern
EP14191582.7A EP2848258B1 (de) 2005-10-26 2006-10-24 Behandlung des familiären Mittelmeer-Fiebers mit anti-IL-1beta-Antikörpern
PCT/US2006/041479 WO2007050607A2 (en) 2005-10-26 2006-10-24 Novel use of il-1beta compounds

Related Parent Applications (5)

Application Number Title Priority Date Filing Date
EP14191582.7A Division EP2848258B1 (de) 2005-10-26 2006-10-24 Behandlung des familiären Mittelmeer-Fiebers mit anti-IL-1beta-Antikörpern
EP14191582.7A Previously-Filed-Application EP2848258B1 (de) 2005-10-26 2006-10-24 Behandlung des familiären Mittelmeer-Fiebers mit anti-IL-1beta-Antikörpern
EP14191582.7A Division-Into EP2848258B1 (de) 2005-10-26 2006-10-24 Behandlung des familiären Mittelmeer-Fiebers mit anti-IL-1beta-Antikörpern
EP06826560A Division EP1940465B1 (de) 2005-10-26 2006-10-24 Neue verwendung von anti il-1-beta-antikörpern
EP10181100A Division EP2332577A1 (de) 2005-10-26 2006-10-24 Neuartige Verwendung von IL-1beta-Verbindungen

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP23155348.8A Division EP4218815A3 (de) 2005-10-26 2006-10-24 Verwendung von anti il-1-beta-antikörpern
EP23155348.8A Previously-Filed-Application EP4218815A3 (de) 2005-10-26 2006-10-24 Verwendung von anti il-1-beta-antikörpern

Publications (3)

Publication Number Publication Date
EP3332807A2 EP3332807A2 (de) 2018-06-13
EP3332807A3 true EP3332807A3 (de) 2018-06-20
EP3332807B1 EP3332807B1 (de) 2023-02-22

Family

ID=37806690

Family Applications (5)

Application Number Title Priority Date Filing Date
EP17199544.2A Active EP3332807B1 (de) 2005-10-26 2006-10-24 Verwendung von anti il-1-beta-antikörpern
EP06826560A Active EP1940465B1 (de) 2005-10-26 2006-10-24 Neue verwendung von anti il-1-beta-antikörpern
EP10181100A Withdrawn EP2332577A1 (de) 2005-10-26 2006-10-24 Neuartige Verwendung von IL-1beta-Verbindungen
EP14191582.7A Active EP2848258B1 (de) 2005-10-26 2006-10-24 Behandlung des familiären Mittelmeer-Fiebers mit anti-IL-1beta-Antikörpern
EP23155348.8A Pending EP4218815A3 (de) 2005-10-26 2006-10-24 Verwendung von anti il-1-beta-antikörpern

Family Applications After (4)

Application Number Title Priority Date Filing Date
EP06826560A Active EP1940465B1 (de) 2005-10-26 2006-10-24 Neue verwendung von anti il-1-beta-antikörpern
EP10181100A Withdrawn EP2332577A1 (de) 2005-10-26 2006-10-24 Neuartige Verwendung von IL-1beta-Verbindungen
EP14191582.7A Active EP2848258B1 (de) 2005-10-26 2006-10-24 Behandlung des familiären Mittelmeer-Fiebers mit anti-IL-1beta-Antikörpern
EP23155348.8A Pending EP4218815A3 (de) 2005-10-26 2006-10-24 Verwendung von anti il-1-beta-antikörpern

Country Status (29)

Country Link
US (8) US8105587B2 (de)
EP (5) EP3332807B1 (de)
JP (4) JP2009513645A (de)
KR (3) KR101749388B1 (de)
CN (2) CN101291693B (de)
AU (1) AU2006306280B2 (de)
BR (1) BRPI0617830B8 (de)
CA (3) CA2898369C (de)
CY (4) CY1113378T1 (de)
DK (2) DK2848258T3 (de)
ES (3) ES2662420T3 (de)
HK (3) HK1121041A1 (de)
HU (2) HUE036973T2 (de)
IL (4) IL190545A (de)
JO (2) JO2826B1 (de)
LT (3) LT2848258T (de)
LU (2) LU92326I2 (de)
MA (1) MA29919B1 (de)
NO (2) NO345888B1 (de)
NZ (1) NZ567222A (de)
PH (2) PH12013501287B1 (de)
PL (2) PL2848258T3 (de)
PT (2) PT1940465E (de)
RU (2) RU2468817C2 (de)
SI (2) SI2848258T1 (de)
TN (1) TNSN08189A1 (de)
TR (1) TR201802449T4 (de)
TW (3) TWI537003B (de)
WO (1) WO2007050607A2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8105587B2 (en) 2005-10-26 2012-01-31 Novartis Ag Methods of treating arthritis using IL-1β binding molecules
AU2012203931B2 (en) * 2007-05-29 2014-04-24 Novartis Ag New indications for anti-IL-I-beta therapy
JP2010528086A (ja) * 2007-05-29 2010-08-19 ノバルティス アーゲー 抗ｉｌ−１治療に関する新しい適応症
AU2009256072B2 (en) * 2008-06-06 2015-05-28 Xoma (Us) Llc Methods for the treatment of rheumatoid arthritis
EP2196476A1 (de) 2008-12-10 2010-06-16 Novartis Ag Antikörperformulierung
EP2477647B1 (de) 2009-09-14 2016-01-13 The Regents of the University of Colorado Modulation von immuntherapeutischen produkten auf hefebasis und reaktionen
RU2012119788A (ru) * 2009-10-15 2013-11-20 Эбботт Лэборетриз Связывающие il-1 белки
AR081246A1 (es) * 2010-05-14 2012-07-18 Abbott Lab Proteinas de union a il-1
BR112013015944A2 (pt) * 2010-12-21 2018-06-19 Abbvie Inc imunoglobulinas de domínio duplo variável il-1 alpha e beta biespecífico e seus usos.
CA2839792A1 (en) 2011-05-10 2012-11-15 Nestec S.A. Methods of disease activity profiling for personalized therapy management
US11377656B2 (en) 2016-03-10 2022-07-05 Novartis Ag Chemically modified messenger RNA's
CA3064529C (en) 2017-05-31 2021-12-14 Prometheus Biosciences, Inc. Methods for assessing mucosal healing in crohn's disease patients
UY37758A (es) 2017-06-12 2019-01-31 Novartis Ag Método de fabricación de anticuerpos biespecíficos, anticuerpos biespecíficos y uso terapéutico de dichos anticuerpos
WO2018235056A1 (en) 2017-06-22 2018-12-27 Novartis Ag IL-1BETA BINDING ANTIBODIES FOR USE IN THE TREATMENT OF CANCER
WO2019215484A1 (en) 2018-05-09 2019-11-14 Novartis Ag Use of canakinumab
EP3897613A1 (de) 2018-12-21 2021-10-27 Novartis AG Verwendung von il-1beta-bindenden antikörpern
CA3119584A1 (en) 2018-12-21 2020-06-25 Novartis Ag Use of il-1 beta antibodies in the treatment or prevention of myelodysplastic syndrome
WO2020128620A1 (en) 2018-12-21 2020-06-25 Novartis Ag Use of il-1beta binding antibodies
WO2020128637A1 (en) 2018-12-21 2020-06-25 Novartis Ag Use of il-1 binding antibodies in the treatment of a msi-h cancer
TWI793503B (zh) * 2020-01-20 2023-02-21 美商美國禮來大藥廠 抗IL-1β抗體
WO2023132698A1 (ko) * 2022-01-10 2023-07-13 (주)지아이이노베이션 글루카곤-유사 펩타이드-1 및 인터루킨-1 수용체 길항제를 포함하는 퇴행성 뇌질환 예방 또는 치료용 약학 조성물

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PT1210320E (pt) * 1999-07-16 2005-01-31 Leo Pharma As Aminobenzofenonas como inibidores de il-1beta e tnf-alfa
AU783158B2 (en) 1999-08-24 2005-09-29 Ariad Pharmaceuticals, Inc. 28-epirapalogs
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