EP3162727A2 - Dispositif de fermeture pour coupler des récipients - Google Patents

Dispositif de fermeture pour coupler des récipients Download PDF

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Publication number
EP3162727A2
EP3162727A2 EP16196524.9A EP16196524A EP3162727A2 EP 3162727 A2 EP3162727 A2 EP 3162727A2 EP 16196524 A EP16196524 A EP 16196524A EP 3162727 A2 EP3162727 A2 EP 3162727A2
Authority
EP
European Patent Office
Prior art keywords
closure
container
holes
female element
male element
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP16196524.9A
Other languages
German (de)
English (en)
Other versions
EP3162727A3 (fr
EP3162727B1 (fr
Inventor
Gabriele CIPRESSI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bio-Optica Milano SpA
Original Assignee
Bio-Optica Milano SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio-Optica Milano SpA filed Critical Bio-Optica Milano SpA
Publication of EP3162727A2 publication Critical patent/EP3162727A2/fr
Publication of EP3162727A3 publication Critical patent/EP3162727A3/fr
Application granted granted Critical
Publication of EP3162727B1 publication Critical patent/EP3162727B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/20—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge
    • B65D47/26—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge with slide valves, i.e. valves that open and close a passageway by sliding over a port, e.g. formed with slidable spouts
    • B65D47/261—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge with slide valves, i.e. valves that open and close a passageway by sliding over a port, e.g. formed with slidable spouts having a rotational or helicoidal movement
    • B65D47/265—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge with slide valves, i.e. valves that open and close a passageway by sliding over a port, e.g. formed with slidable spouts having a rotational or helicoidal movement between planar parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D41/00—Caps, e.g. crown caps or crown seals, i.e. members having parts arranged for engagement with the external periphery of a neck or wall defining a pouring opening or discharge aperture; Protective cap-like covers for closure members, e.g. decorative covers of metal foil or paper
    • B65D41/02—Caps or cap-like covers without lines of weakness, tearing strips, tags, or like opening or removal devices
    • B65D41/04—Threaded or like caps or cap-like covers secured by rotation
    • B65D41/0407—Threaded or like caps or cap-like covers secured by rotation with integral sealing means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3205—Separate rigid or semi-rigid containers joined to each other at their external surfaces
    • B65D81/3211—Separate rigid or semi-rigid containers joined to each other at their external surfaces coaxially and provided with means facilitating admixture
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2217/00—Details of mixing containers or closures
    • B65D2217/04—Whereby the separation between the different product compartments can be restored, e.g. for reuse
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2251/00—Details relating to container closures
    • B65D2251/06—Special configurations; Closures simulating or provided with another item, e.g. puppet, animal, vehicle, building
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2251/00—Details relating to container closures
    • B65D2251/09—Reversible caps or lids, e.g. with threads on one side and a plug on the other

Definitions

  • the present invention relates to a closure for a device for processing biological samples.
  • protocols provide that a sample collected from a patient or a biopsy is treated as soon as possible with appropriate substances, called fixatives, before being sent to the laboratory responsible for testing to be subjected to the further processing steps.
  • formaldehyde is a fixative liquid which is very widely and commonly used in everyday laboratory practice, for which the toxic effects are known.
  • some of them provide that the sample is placed within a container closed with a cap; the fixative liquid instead is contained and preserved in a specific housing in the cap of the container, and such a housing is closed by a separation membrane.
  • the breakage of the membrane obtained by actuation of a perforation system, thus allows the flow of fixative liquid towards the sample.
  • such a container consists of two elements, container and cap, which must necessarily be used in association, because they are designed to cooperate functionally with each other.
  • the breakage mechanism of the membrane is cumbersome in itself and reduces the volume available for the fixative liquid.
  • the technical problem underlying the present invention is thus to make a device available to anatomic pathology laboratory operators for processing, in particular for the fixation of, a biological sample which is simple and intuitive to use, practical, not very cumbersome and low-cost.
  • the described device does not comprise partitions (septum) or separation membranes, does not comprise breakage mechanisms of partitions or separation membranes.
  • a device according to the present invention is indicated as a whole by reference numeral 100.
  • the device 100 comprises a first container 101 and a second container 102 upside down over the top 101.
  • Each of the two containers 101,102 is closed by a cap element 103,104; the two cap elements 103,104 jointly form the closure 105 of the present invention.
  • the closure 105 comprises a male (cap) element 103 and a female (cap) element 104, connected to each other so as to allow the reciprocal rotation of one with respect to the other about the longitudinal axis X, as shown by the arrows in figure 1 and as detailed in the description below.
  • the male element 103 is substantially shaped as a bottle cap and comprises a portion for closing the first container 101, means for the passage of a fluid from the container 101 to the other container 102, and vice versa, and a coupling portion with the female element 104.
  • the container 105 may be closed by means of an appropriate threading system 106, but other equivalent systems are also possible.
  • the male element 103 comprises a truncated-cone-shaped portion 107 open towards the bottom, a side wall 108 and an upper base 109.
  • the side wall 108 protrudes beyond the upper base 109 and originates an inwardly jutting edge 110, which defines a ring seat 111.
  • said edge 111 comprises a rounded inner profile 112.
  • the female element 104 is also substantially shaped as a bottle cap and comprises a portion for closing the second container 102, means for the passage of a fluid to the other container 101 and vice versa, and a coupling portion with the male element 103.
  • the second container 102 may be closed by means of an appropriate threading system 114 or with equivalent systems.
  • the female element 104 comprises a truncated-cone-shaped central portion 115 open at the bottom, a side wall 116 and an upper base 117, which mutually originate a circumferential edge 118.
  • the side wall 116 is not continuous and near the upper base 117 has a "C"-shaped recess 119, which forms a ring seat 120 having a step 121, a side wall 122 and an upper wall 123.
  • Through holes 124 are obtained in the upper base 117.
  • the number of through holes present in the two elements 103, 104 is the same.
  • the two elements 103,104 are coupled by fitting to obtain the closure 105 of the invention.
  • the male element 103 is upside down and rests on the other element 104 so that the two truncated-cone-shaped elements 107,115 match, and then pressed so as to fit the jutting edge 110 inside the housing 120.
  • the fitting is promoted by the rounded profile 112.
  • the fitting allows the rotation of one element 103 with respect to the other 104 about the axis X.
  • Identifying the configuration of the device 100 of the present invention may be advantageously facilitated by affixing appropriate indicator means 125 clearly visible on the closure 105, as shown in figure 1 , for example.
  • the passage from one configuration to the other may be obtained by rotating one container 101 with respect to the other 102 about the axis X.
  • the coupling between the two elements 103,104 of the closure 105 may be obtained either alternatively or additionally to the fitting system described above, also by means of an appropriate connection pin 126 with a sealing O-ring (not shown in figure).
  • a pin central to the two bases 109,117 may be provided with a sealing O-ring.
  • the described closure 105 further comprises elements 220 to seal the holes 113 of the male element 103.
  • such elements 220 are comprised in the female element 104.
  • the base of the female element 117 comprises seats 221 for housing said elements 220.
  • said elements 220 are made of elastic and deformable material.
  • said elements 220 are represented by elastic and deformable material balls.
  • Such deformable material is, for example, represented by an elastic polymer.
  • such balls are made of silicon material.
  • the number of the elements 220 for sealing the holes 113 corresponds to the number of holes.
  • two balls of silicon material may be provided, each of which intended to close one of the two holes 113.
  • fixative liquid e.g. formaldehyde
  • the container 101 with the closure 105 is turned over by the operator onto the container 102, in which the sample to be processed 127 is placed.
  • the second container 102 is thus closed.
  • the operator rotates the elements 103,104 of the closure 105 in opposite direction about the axis X until the holes 113,124 match in the open configuration towards the opening configuration.
  • the fixing liquid can flow towards the sample by inclining the device.
  • the closure 105 is placed in the closed configuration to prevent the fixative liquid and the sample (if small in size) from coming accidentally again in the container 101.
  • the device 100 may be turned upside down so that after having reopened the closing system 105, the fixative liquid is collected completely in the first container 101; finally, the closure 105 is placed in closed configuration again.
  • the sample 127 may thus be extracted and subjected to the further processing steps.
  • such elements 220 are in the position which matches the position of said holes 113 in the "CLOSED" configuration.
  • biological samples may be processed in different manners.
  • loose fresh samples inserted in the container can be processed, or samples can be processed in appropriate "cassettes" for inclusion or biopsies or samples attached to appropriate supports can be processed.
  • the biological samples may be biopsies taken by means of appropriate instruments and samples attached to appropriate support elements such as, for example, the Endokit device (a patent of Bio-Optica Milano S.p.A.).
  • Figure 7 shows details of a preferred constructive example of the closure of the invention comprising two balls 220 made of silicon material which close and seal the holes of the male element 113.
  • the balls 220 are housed in seats 221 which are part of the base 117 of the female element and which are arranged in position corresponding to the holes of the male element 113.
  • closure and the described device are simple and intuitive to use, practical and easy to handle.
  • the described closure can be adapted to different types of containers, provided they are compatible.
  • a person skilled in the art may particularly appreciate how the device eliminates the problem of exposing the operator to toxic or potentially toxic substances and simplifies the processing operations, and more in general, the preparation operations of the samples to be analyzed.
  • the device according to the invention further assures that the fixative liquid may be easily and completely retrieved at the end of the operations for safe disposal (special waste).
  • closure of the invention may be adapted to any container with no particular limits.
  • the present invention may also be made in the form in which the housing seats of the elements for sealing the holes are comprised in the male element and, consequently, close and seal and the holes of the female element.
  • plastic materials which are approved and authorized for the specific use may be used. Colors and shapes may vary according to particular needs or preferences without departing from the main function described above.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Closures For Containers (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
EP16196524.9A 2015-10-30 2016-10-31 Dispositif de fermeture pour coupler des récipients Active EP3162727B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITUB2015A004921A ITUB20154921A1 (it) 2015-10-30 2015-10-30 Chiusura per dispositivo per la processazione di campioni biologici

Publications (3)

Publication Number Publication Date
EP3162727A2 true EP3162727A2 (fr) 2017-05-03
EP3162727A3 EP3162727A3 (fr) 2017-07-12
EP3162727B1 EP3162727B1 (fr) 2020-05-27

Family

ID=55359595

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16196524.9A Active EP3162727B1 (fr) 2015-10-30 2016-10-31 Dispositif de fermeture pour coupler des récipients

Country Status (4)

Country Link
EP (1) EP3162727B1 (fr)
ES (1) ES2812759T3 (fr)
IT (1) ITUB20154921A1 (fr)
PT (1) PT3162727T (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107128609A (zh) * 2017-05-15 2017-09-05 李香帅 多项液料调配任意组合瓶
IT201700051294A1 (it) * 2017-05-11 2018-11-11 Diapath S P A Dispositivo e metodo per la raccolta, la conservazione e/o il trasporto di campioni biologici
WO2020189973A1 (fr) * 2019-03-18 2020-09-24 전영복 Bouchon de contenant de boisson à remplissage d'additif auxiliaire
EP3766579A1 (fr) * 2019-07-19 2021-01-20 Illinois Tool Works Inc. Récipient pour échantillons biologiques
IT201900023115A1 (it) 2019-12-05 2021-06-05 Bio Optica Milano S P A Soluzione e metodo per il controllo della processazione di un campione istologico

Family Cites Families (9)

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US4105142A (en) * 1976-10-07 1978-08-08 Morris Jr Harold K Dispensing device for fluid substances
DE9206097U1 (de) * 1992-04-28 1992-08-20 Combitool AG, Bäretswil Tubenverschluss
US5947171A (en) * 1997-01-30 1999-09-07 American Cyanamid Company Valve assembly for use with containers in a closed application system
US20070221513A1 (en) * 2006-03-23 2007-09-27 Keith Taylor-Sharp Dual containers having mechanism for mixing and separating contents of containers
US20080142032A1 (en) * 2006-12-13 2008-06-19 Marc Anthony Venture Corporation Hair dye touch-up dispenser and method of using the same
TW201106942A (en) * 2009-04-23 2011-03-01 Senju Pharma Co Container for mixing before use
JP4543122B1 (ja) * 2009-06-11 2010-09-15 正治 篠部 飲料用容器
JP6151261B2 (ja) * 2011-10-27 2017-06-21 エルブイエムエイチ レシェルシェ 製品容器、特に化粧品容器用の閉鎖キャップ
US20140291277A1 (en) * 2013-03-27 2014-10-02 Diane Perez Bottle transfer device

Non-Patent Citations (1)

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Title
None

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201700051294A1 (it) * 2017-05-11 2018-11-11 Diapath S P A Dispositivo e metodo per la raccolta, la conservazione e/o il trasporto di campioni biologici
WO2018207010A1 (fr) * 2017-05-11 2018-11-15 Diapath S.P.A. Dispositif et procédé de collecte, de conservation et/ou de transport d'échantillons biologiques
CN107128609A (zh) * 2017-05-15 2017-09-05 李香帅 多项液料调配任意组合瓶
WO2020189973A1 (fr) * 2019-03-18 2020-09-24 전영복 Bouchon de contenant de boisson à remplissage d'additif auxiliaire
KR20200110913A (ko) * 2019-03-18 2020-09-28 전영복 보조 첨가물 충진용 음료용기캡
EP3766579A1 (fr) * 2019-07-19 2021-01-20 Illinois Tool Works Inc. Récipient pour échantillons biologiques
CN114126406A (zh) * 2019-07-19 2022-03-01 伊利诺斯工具制品有限公司 用于生物样本的容器
CN114126406B (zh) * 2019-07-19 2024-04-05 伊利诺斯工具制品有限公司 用于生物样本的容器
IT201900023115A1 (it) 2019-12-05 2021-06-05 Bio Optica Milano S P A Soluzione e metodo per il controllo della processazione di un campione istologico
EP3832286A1 (fr) 2019-12-05 2021-06-09 Bio-Optica Milano S.p.A. Solution et procede de controle du traitement d'un echantillon histologique

Also Published As

Publication number Publication date
ITUB20154921A1 (it) 2017-04-30
ES2812759T3 (es) 2021-03-18
EP3162727A3 (fr) 2017-07-12
EP3162727B1 (fr) 2020-05-27
PT3162727T (pt) 2020-08-31

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