EP3154601A1 - Implant auto-courbant - Google Patents

Implant auto-courbant

Info

Publication number
EP3154601A1
EP3154601A1 EP15750624.7A EP15750624A EP3154601A1 EP 3154601 A1 EP3154601 A1 EP 3154601A1 EP 15750624 A EP15750624 A EP 15750624A EP 3154601 A1 EP3154601 A1 EP 3154601A1
Authority
EP
European Patent Office
Prior art keywords
implant
base body
water
permeable
implants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15750624.7A
Other languages
German (de)
English (en)
Inventor
Theodor Doll
Jan STIEGHORST
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Horsys GmbH
Original Assignee
Horsys GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Horsys GmbH filed Critical Horsys GmbH
Publication of EP3154601A1 publication Critical patent/EP3154601A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/14Materials or treatment for tissue regeneration for ear reconstruction or ear implants, e.g. implantable hearing aids

Definitions

  • the invention presented here generally addresses the field of medical technology, with an emphasis on individualized medical implant delivery.
  • implants In the development of implants, as well as in the clinical use of these, it is generally known that implants must be positioned as specifically as possible at the individual target site in the patient for optimum effect. If this is not the case, the implant can not only fulfill its intended function in the worst case, but also damage healthy structures and processes.
  • a pacemaker electrode, an electrode shaft of a cochlear implant, a deep brain stimulation probe, or a brain stem implant would be useless if their electrode contacts were not positioned in close proximity to the targeted cells.
  • Implants are fixed with screws, embedded in milled bone cavities, glued and sewn on. Modern approaches continue to rely on preformed or on memory metals equipped implants that cling to the targeted target structures for the duration of use of the implant and are also intended to hold (for example, nitinol stents or vpcgeoformte cochlear implants).
  • implants that cling to the targeted target structures for the duration of use of the implant and are also intended to hold (for example, nitinol stents or vpcgeoformte cochlear implants).
  • a known problem with these methods is that they only seem to adapt to the individual anatomy of the patient. Rather, they move back into their predetermined by the manufacturing mold after holding devices were removed, or the memory effect was triggered.
  • a new, as yet unmercialized, research approach relies on partially detaching hydrophilic polymers which can be attached to the apical and basal ends of a cylindrical implant and, when inserted into a tube, allow for backside impressions (US Pat. No. 8,145,326 B2). This allows the front of the implant to be removed from the back.
  • Application is to find this method in cochlear implants, so as to allow a nerve-near position of an electrode carrier, see Application Example 1.
  • Significant disadvantages of this method are the very limited achievable curvature, the simultaneous exposure of the swelling polymer to the extracellular matrix and the Surface pressure of the surrounding tissue.
  • Asymmetric distribution of individual implant components with different moduli of elasticity can create areas of higher and lower stiffness in the implant, resulting in an asymmetric distribution of flexural stiffness. If a mechanical (swelling) pressure is now introduced into the implant, an expansion takes place primarily in the direction of the lowest rigidity. Areas of higher stiffness are comparatively hardly stretched.
  • the influences of different degrees of crosslinking and cross-linking parameters of the swelling polymer can be evaluated.
  • the encapsulation of the implant body with a biocompatible and degradable hydrogel e.g., PVP
  • PVP degradable hydrogel
  • Embodiment 1 Use of the proposed invention in one
  • Electrode shaft of cochlear implant systems is a cochlear implant system
  • cochlear implants are used in modern medicine, which enable a partial recovery of the hearing.
  • the . failed function of degenerated or non-congenital hair cells replaced by electrical stimulation of the auditory nerve cells in the helical cochlea.
  • the key component here is the cylindrical silicone electrode carrier, which contains the platinum electrode contacts and platinum connecting wires required for the stimulation.
  • the electrode shaft is When implanted through an operative orifice as close as possible to the modiolus, place it in the scala tympani (below the basilar membrane) of the cochlea to reduce the distance between the electrode contacts and the nerve cells, see Figure 1.
  • the basis for the bend would be the asymmetric distribution of flexural stiffness due to the front electrode contacts and leads, which leads to reduced strain on the modiolar and increased strain on the dorsal side of the electrode shaft during swelling of the polymer.
  • the electrode contacts For the production of the electrode shaft, the electrode contacts must first be inserted and positioned in the casting mold. Subsequently, medical grade liquid silicone rubber (LSR) is mixed with a polyacrylamide powder of certain particle size distribution and quantity. The powder should have a balanced proportion of small and large grains, which on the one hand act as a chemical blending and on the other can form large swelling areas. The liquid produced should then be extruded into the mold and then vulcanized according to the manufacturer's instructions. In order to react or evaporate unreacted monomers, the electrode shaft should be finally tempered.
  • LSR liquid silicone rubber
  • the concept of the proposed invention allows individual and active adaptation and positioning of implant surfaces to dedicated target surfaces in the human body. Compared to the o.g. Known approaches (preformed or equipped with memory metals electrode carrier), the curvature effect is induced promptly after implantation in the body, wherein the active element remains encapsulated in the implant body and thus not the extracellular matrix is exposed.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Composite Materials (AREA)
  • Dispersion Chemistry (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne un implant auto-courbant. Les implants médicaux connus sont placés et fixés chez la personne afin de garantir leur fonctionnement sur le long terme et de manière optimale à l'endroit cible. L'idéal serait toutefois un implant qui non seulement conserve la position prédéterminée lors de la fabrication et de l'implantation mais qui s'adapterait également après l'implantation de manière active aux structures anatomiques de chaque patient. Les systèmes disponibles actuellement utilisent à cet effet des implants préformés qui peuvent se (re-)déplacer pour prendre uniquement une forme prédéfinie fixe. Une adaptation individuelle n'est ainsi pas réalisée. Le procédé de la présente invention permet comparativement une adaptation individuelle ajustable grâce à une courbure active de l'implant. Ce procédé consiste à insérer dans un corps de base d'implant hydrophobe un polymère hydrophile qui gonfle en absorbant l'eau et induit ainsi une courbure. Les conditions de son obtention sont une distribution asymétrique de la rigidité en flexion dans l'implant et/ou un placement excentré du polymère gonflant dans le corps de base de l'implant. Un exemple de possibilité d'utilisation de l'invention est constitué par des supports d'électrodes auto-courbants d'implants cochléaires, permettant d'obtenir un positionnement à proximité du nerf.
EP15750624.7A 2014-06-13 2015-06-12 Implant auto-courbant Withdrawn EP3154601A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102014008397 2014-06-13
PCT/DE2015/000281 WO2015188805A1 (fr) 2014-06-13 2015-06-12 Implant auto-courbant

Publications (1)

Publication Number Publication Date
EP3154601A1 true EP3154601A1 (fr) 2017-04-19

Family

ID=53871789

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15750624.7A Withdrawn EP3154601A1 (fr) 2014-06-13 2015-06-12 Implant auto-courbant

Country Status (2)

Country Link
EP (1) EP3154601A1 (fr)
WO (1) WO2015188805A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102016110137A1 (de) 2016-06-01 2017-12-07 Medizinische Hochschule Hannover Formadaptives medizinisches Implantat sowie Verwendung einer elektrischen Signalquelle

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS251890B1 (en) * 1985-05-20 1987-08-13 Jiri Sulc Hydrophilic silicon composition and method of its production
SK278745B6 (sk) * 1989-05-24 1998-02-04 �Stav Makromolekul�Rn� Chemie Av �R Vodou a vodnými roztokmi napúčateľné gumy a spôsob
DE4216271A1 (de) 1992-05-16 1993-11-18 Siegel Rolf Verfahren zur naßchemischen Oberflächenmodifizierung von Formkörpern aus Organopolysiloxanen sowie Verwendung der Verfahrenserzeugnisse
WO2002043623A1 (fr) 2000-11-29 2002-06-06 Cochlear Limited Ensemble d'electrodes d'implant cochleaire prealablement recourbees
ES2222116T1 (es) 2001-09-13 2005-02-01 Med-El Elektromedizinische Gerate Ges.M.B.H. Electrodo intracoclear con segmento hidrofilo parcialmente desprendible para autodeposicion aplazada.
AU2009282576B2 (en) * 2008-08-20 2015-04-02 Allergan, Inc. Self-sealing shell for inflatable prostheses
US8473075B2 (en) 2010-06-25 2013-06-25 Advanced Bionics Cochlear implant system with removable stylet

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
None *
See also references of WO2015188805A1 *

Also Published As

Publication number Publication date
WO2015188805A1 (fr) 2015-12-17

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