EP3070425A1 - Lyophilisateur doté d'un hublot - Google Patents

Lyophilisateur doté d'un hublot Download PDF

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Publication number
EP3070425A1
EP3070425A1 EP15159161.7A EP15159161A EP3070425A1 EP 3070425 A1 EP3070425 A1 EP 3070425A1 EP 15159161 A EP15159161 A EP 15159161A EP 3070425 A1 EP3070425 A1 EP 3070425A1
Authority
EP
European Patent Office
Prior art keywords
freeze dryer
viewing window
coating
freeze
layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP15159161.7A
Other languages
German (de)
English (en)
Other versions
EP3070425B1 (fr
Inventor
Michael Umbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MARTIN CHRIST GEFRIERTROCKNUNGSANLAGEN GmbH
Original Assignee
MARTIN CHRIST GEFRIERTROCKNUNGSANLAGEN GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MARTIN CHRIST GEFRIERTROCKNUNGSANLAGEN GmbH filed Critical MARTIN CHRIST GEFRIERTROCKNUNGSANLAGEN GmbH
Priority to ES15159161.7T priority Critical patent/ES2690269T3/es
Priority to EP15159161.7A priority patent/EP3070425B1/fr
Priority to US15/071,307 priority patent/US20160273835A1/en
Priority to CN201610149650.1A priority patent/CN105987583B/zh
Publication of EP3070425A1 publication Critical patent/EP3070425A1/fr
Application granted granted Critical
Publication of EP3070425B1 publication Critical patent/EP3070425B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
    • F26B25/06—Chambers, containers, or receptacles
    • F26B25/08—Parts thereof
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
    • F26B25/001—Handling, e.g. loading or unloading arrangements
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing

Definitions

  • the invention relates to a freeze dryer. Furthermore, the invention relates to a new use of a material.
  • Freeze dryers are used for gentle drying of a high-quality, thermally sensitive drying material, in particular a pharmaceutical or biochemical drying material.
  • the material to be dried contains liquid which is to be eliminated by freeze-drying and which is preferably high-purity water or a solvent.
  • a drying material is freeze-dried in containers. Any container, in particular a drying vessel, a vial, an ampoule, a bowl or a so-called vial, with the drying material arranged therein is also referred to below as a product.
  • a product chamber of a freeze dryer several shelves are arranged one above the other for many known embodiments.
  • a closable by a door opening products can be introduced into the product chamber and placed on the shelves.
  • the product is then first frozen in the product chamber of the freeze dryer.
  • a so-called primary drying is carried out by sublimated in the product chamber at low pressure or technical vacuum and low temperature, the solvent contained in the Trocknungsgut without intermediate occurrence of a liquid phase directly from the frozen state to the gaseous state.
  • an ice condenser chamber connected to or integrally formed with the product chamber, for example on a refrigerated cold trap of the ice condenser chamber, the previously sublimated solvent precipitates as ice.
  • a secondary drying in which by a pressure reduction and / or further heating more strongly bound solvent is removed.
  • Trocknungsgut which is also referred to as lyophilisate.
  • the pressure, temperature and other parameters are controlled or controlled according to a product-specific sublimation pressure curve to achieve good and reproducible drying results. Freeze dryers are often operated discontinuously.
  • freeze dryers Whilst freeze dryers are well known in which the housing incl.
  • the door is formed opaque, for example.
  • freeze dryer are also known in which a door is formed with a disc of inorganic glass or acrylic glass, so that the door a window forms through which the interior of the freeze dryer is visible even when the door is closed (see, for example, the embodiments "Epsilon" pilot freeze drying plants and the different production facilities of the applicant, as this on the website www.martinchrist.de [as of filing the present patent application] are described and shown).
  • the publication EP 1 412 686 B1 describes the need to produce in the product chamber of a freeze dryer a uniform water vapor partial pressure with uniform pressure distribution also in the area of the chamber walls and any door.
  • the document describes the observation that in the area of the chamber walls and the door the temperature of the products depends not only on the temperature of the cooled control panels. Rather, the temperature of the inner walls of the product chamber also influences the temperature of the products by means of heat radiation. If, for example, the steam leaving the product has a temperature of -40.degree. C., this temperature increases on the control panels to, for example, -20.degree. C., while under certain circumstances the steam in the vicinity of the walls may increase, for example. B. can reach 20 ° C.
  • the document suggests DE 10 2007 049 278 B4 to arrange a thermally insulating screen between the underside of a cold radiating footprint and a further footprint arranged thereunder with products arranged thereon.
  • a shield should be such that a cold transfer from the bottom of the upper footprint to the underlying further footprint with products arranged thereon is avoided, thus allowing a more accurate control of the temporal freezing profile of the products.
  • the viewing window is formed with a reduced radiation transmission.
  • a viewing window of inorganic glass or of organic glass, in particular an acrylic glass or transparent plastic glass of materials such as PMMA, PC, PET, SAN, PVC, etc.
  • measures are taken in the context of the invention that the radiation transmission of the viewing window used according to the invention is smaller (for example, in the entire frequency range or only in the relevant frequency range 10%, 20%, 30%, 50% or even 70% smaller) than the radiation transmissibility of a viewing window of the same dimensions of the same inorganic glass ( or from the same organic glass, in particular from a transparent plastic glass) without the additional measures according to the invention for reducing the radiation permeability.
  • At least one of the previously explained problems a) to c) can be at least reduced by the reduction of the radiation transmissibility according to the invention, ie a heating of products in the irradiation range of light in the region of the viewing window (see a)) or a reduction of the reflection of electromagnetic radiation in the region the viewing window (see b) and c)) are reduced or avoided altogether (the measures according to the invention being not limited to the purpose of eliminating these problems exemplified).
  • the viewing window is formed with a layer or coating with reduced radiation transmission.
  • the viewing window can be formed, for example, with other layers or a base body of a "conventional material" of the viewing window, for example.
  • Organic glass such as transparent plastic glass or inorganic glass.
  • the layer or the coating can then additionally be used to reduce the radiation permeability, it being possible to influence the extent of the reduction of the radiation permeability by dimensioning the layer or coating and selecting the material of the layer or coating.
  • the layer or coating should be selected such that the viewing window also remains transparent through the layer or coating, whereby a certain impairment of the transparency (such as a slight darkening and / or a specular effect at particular viewing angles through the viewing window) may be present can. It is also possible to retrofit an existing viewing window with such a layer or coating.
  • the viewing window can be formed with a base body, for example of inorganic glass or transparent plastic glass, on which the layer or coating is applied on the inside with respect to the freeze dryer or the outside.
  • a base body for example of inorganic glass or transparent plastic glass
  • the layer or coating is applied on the inside with respect to the freeze dryer or the outside.
  • a multi-layer structure of the body with different materials whereby a layer or coating with reduced radiation transmission in the interior of the viewing window, ie between adjacent layers of another material, may be arranged. It is also possible that several layers or coatings are used with reduced radiation transmission.
  • the radiation transmission is reduced to the same extent over the surface of the viewing window.
  • the viewing window may have areas of different reductions in radiation transmissibility, for example a central field with a reduced extent of reduction in radiation transmission, for example, to limit or limit viewing, and an edge area outside of the central area to increase the Extent of reduction of radiation transmission.
  • a film which may be adhered to a base body or an adjacent layer may be used as a coating with reduced radiation transmission, a film which may be adhered to a base body or an adjacent layer. It is possible that such a film is formed as a kind of film. There are many possibilities for the design of the film. For example, a film with an amorphous cobalt alloy can be used here. As another example, a layer with reduced radiation transmission may be formed with a lacquer. It is also possible that a layer vapor-deposited onto a main body or adjacent layers is used as the layer with reduced radiation permeability.
  • a layer or coating with reduced radiation transmission is formed with a fabric, mesh or mesh, wherein here as the fabric, mesh or mesh-forming material any materials, in particular polyester, metal, stainless steel, silver-polyamide fibers u. ⁇ . Can be used. It is also possible that the layer formed with the fabric, mesh or grid is interspersed with a material of an adjacent layer or a base body, with which the fabric, mesh or grid is "embedded" in the material of the adjacent layer or the base body.
  • a nonwoven for example a carbonized polyester nonwoven which may also be penetrated by a material of an adjacent layer or a base body.
  • the viewing window is formed with a conventional material for the formation of a viewing window, in particular inorganic glass, mineral glass, crystal glass, organic glass, acrylic glass or transparent plastic glass.
  • this material of the viewing window is accompanied by an additive with reduced radiation permeability, which, for example, can be dissolved in the abovementioned material or which may be, for example, particles added to the abovementioned material, which are then distributed locally in said material without dissolution in this.
  • the viewing window and in particular the layer or coating with reduced radiation transmission is formed without grounding
  • the viewing window here in particular the layer or Coating with reduced radiation transmission
  • the reduction in the radiation permeability in the low-frequency or high-frequency range may depend primarily on the type of grounding, in particular whether the grounding is punctual or flat.
  • any thicknesses of the viewing window are possible.
  • a reduction of the radiation transmissibility can take place in any relevant frequency range.
  • the viewing window has a reduced radiation transmission for light in a frequency range of 300 GHz and 400 THz, which corresponds to the infrared spectrum of solar radiation.
  • a reduction of the radiation permeability in the mentioned frequency range by 10%, 20%, 30%, 50% or even 70%. This embodiment is based on the finding that the explained undesired effect of the heating of the products in the irradiation area through the viewing window arises primarily from the infrared spectrum of the sunlight.
  • a sensor is arranged in the interior of the freeze dryer, which is excited with an excitation frequency of an external excitation to power the sensor and / or has a measuring signal frequency for the wireless transmission of a measuring signal to a receiver arranged away from inside the freeze-dryer.
  • the viewing window has a reduced radiation transmission in the region of the excitation frequency and / or the measurement signal frequency, that is, the choice of measures taken to reduce the radiation transmission of the viewing window is adapted to the excitation frequency and / or the measurement signal frequency.
  • a freeze-dryer may be in choosing a freeze-dryer, as this in the document DE 10 2006 019 641 B4 a reduction of the radiation transmission in a frequency range of 1.5 GHz to 3 GHz, preferably in a frequency range of 2.0 to 2.8 GHz or 2.2 to 2.6 GHz, carried out. It is also possible that a transmitting antenna of the sensor is multifunctional designed as a receiving antenna.
  • the viewing window has a reduced radiation transmission in a frequency range of 500 MHz, 1800 MHz and / or 1900 MHz (it should also be understood that deviations from these frequencies by ⁇ 5%, ⁇ 10% or ⁇ 20%). are available).
  • a reduction of the radiation transmission in this frequency range has been found to be particularly effective in order to increase the electromagnetic compatibility, in particular in connection with arranged in the surrounding area of the freeze dryer cell phones or wireless technology transmitters.
  • the transmittance of electromagnetic radiation is specifically defined in the standards ASTM D4935-10, IEEE Std 299-2006, IEEEE Std 1128-1998 and ASTM A698 / A698M-07.
  • the radiation transmission can be defined with a so-called screen attenuation, with respect to which reference is made to the aforementioned standards.
  • the viewing window in at least one of the frequency ranges mentioned here or in the entire frequency range, has a screen attenuation according to standard IEEE 299-2006 of 20 dB, preferably at least 25 dB or in the range of 25 dB to 32 dB.
  • the frame it is also possible for the frame to serve further tasks, for example to fasten the viewing window to other housing parts of the freeze dryer or to hold a hinge.
  • a window can form a portion of the housing of the freeze-dryer.
  • the viewing window is formed by a door or flap of the freeze dryer, which, for example, can be closed and opened for loading and unloading the freeze dryer.
  • This embodiment makes use in particular of the fact that usually a door or flap for loading or unloading the freeze drier is arranged at a central region of the housing of the freeze dryer at a small distance to the shelves of the freeze drier, so that when the viewing window in the area the door or flap is also ensured at the same time that a good Insight into the interior of the freeze dryer and on the products through the viewing window is guaranteed.
  • a control unit of the freeze dryer is equipped with control logic.
  • the control logic introduces in the freeze dryer a temperature which is a differential temperature below the freezing temperature of the products freeze-dried in the freeze dryer.
  • the differential temperature is adapted to a screen attenuation of the viewing window.
  • a freezing temperature is about 0 ° C.
  • the temperature of the products should be at least -4 ° C. before initiation of the primary drying, and if the radiation transparency of the viewing window is not reduced according to the invention, the temperature gradient of the samples in the freeze dryer 6K is as a result of an irradiation of light
  • a control unit of the freeze dryer ensure a temperature of the samples, which is at -10 ° C for non-irradiated by the radiation of light samples.
  • the control logic of the control unit of the freeze dryer only a temperature of - 5 C (or - 4.7 ° C or - 4.5 ° C) ausberichtn, which is nevertheless ensured by the inventive measures that all samples a maximum temperature of -4 ° C.
  • a temperature of - 5 C or - 4.7 ° C or - 4.5 ° C
  • an adaptation of the differential temperature is thus possible, which reduces the energy input and allows rapid, gradual sublimation, under certain circumstances also with a reduced temperature gradient.
  • one end face of the viewing window is provided with a layer or coating with reduced radiation permeability.
  • This embodiment of the invention is based on the knowledge that under certain circumstances in the edge region of the viewing window, a radiation exchange between the interior and the exterior of the Freeze-dryer (in one direction or in both directions), which can be reduced by the layer or coating with reduced radiation transmission in the region of the front side of the viewing window.
  • the invention comprises both embodiments in which only a portion of the end face of the viewing window is equipped with the layer or coating with reduced radiation transmission as well as embodiments in which the end face of the viewing window is continuously and circumferentially equipped with such a layer or coating.
  • a housing wall of a product chamber of the freeze dryer forms the viewing window.
  • the product chamber formed by the housing wall is formed separately from an outer housing of the freeze dryer and removable from the outer housing. It is possible that the outer housing forms another window.
  • the arranged in the product chamber products are thus visible in the product chamber in the removed state from the outer housing and visible even through the second-mentioned window when the product chamber is inserted into the outer housing.
  • drying chambers transparent product chambers for the embodiments ALPHA to DELTA website www.martinchrist.de be removed, which are here as a hollow cylindrical, closed with a lid transparent containers, for example. Made of transparent plastic glass and which inside the products can absorb.
  • a basic module of a freeze dryer which forms an ice condenser chamber can be used in different variants.
  • the base module is separated by a valve-equipped intermediate plate of a hood-like housing, which then forms the product chamber.
  • the footprint for the products may be formed inside the ice condenser chamber formed by the base module, and the closure of the base module may be through a lid.
  • the lid or the housing limiting the product chamber is formed with the viewing window, wherein preferably the entire lid or the entire housing can be made of any glass and the previously described measures can be taken to reduce the radiation transmission.
  • a fabric, a layer, a coating, a fleece, a paint, a film, a grid and / or a network which or which reduces a radiation transmission, for different applications, especially for windows of buildings, for clothing, Curtains, curtains, canopies, protective suits, medical equipment, desiccators, microbiological incubators, data center shields and the like.
  • a fabric, a layer, a coating, a fleece, a lacquer, a foil, a grid and / or mesh with reduced radiation permeability or addition for a viewing window of a freeze dryer is proposed for the first time.
  • the coating (s) or the layer (s) as a specially adapted filter, which transmits visible radiation but at the same time reflects or absorbs electromagnetic radiation in a predetermined wavelength range.
  • a noxious wavelength or a wavelength range may be selectively filtered out, e.g. for markers in medicine that are sensitive to specific wavelengths.
  • the products may be fluorescent cancer cell markers activated by electromagnetic waves of a specific frequency.
  • the product must be protected against electromagnetic radiation of that frequency to ensure the later functioning of the product.
  • Manufacturers of such products are, for example, ROTOP PHARMAKA GmbH, Bautzner Landstr. 400 01328 Dresden and Naradowe Centrum Badan Jadrowych, Osrodek Radioizotopow POLATOM ul. Andrzeja Soltana 7 05-400 Otwock-Swierk Polska.
  • Fig. 1 shows a highly schematic of a freeze dryer 1.
  • the freeze dryer 1 has a housing 2.
  • a product chamber 3 (which may also be referred to as a drying chamber) and an ice condenser chamber 4 are formed.
  • the product chamber 3 and the ice condenser chamber 4 are connected to each other via an opening 5, wherein the opening 5 is closed by a valve 6.
  • the product chamber 3 and the ice condenser chamber 4 are separated by a partition 7, which forms the opening 5.
  • the product chamber 3 and the ice condenser chamber 4 are permanently fluidly connected to each other or even formed as a common chamber.
  • a cooling device 12 in particular a cold-end, on which moisture removed from the products during freeze-drying can be deposited as ice.
  • a pump 8 (here with the interposition of a valve 9) is connected to the ice condenser chamber 4, by means of which the pressure conditions in the product chamber 3 and the ice condenser chamber 4 can be predetermined, in particular with the bringing about a technical Vacuum.
  • the product chamber 3 are a plurality of shelves 10a, 10b, ..., which are arranged parallel and one above the other. On the shelves 10, a plurality of products 11, in particular vials, are arranged (which is shown for simplicity of illustration only for a footprint 10d).
  • the shelves 10 may be fixed in the freeze dryer 1 or be adjustable in height, which may be the case in particular for automated loading and unloading.
  • freeze dryer 1 With regard to the structural design details, constructive design variants, the formation of the pressure control devices, heating and cooling devices and the process control of the freeze dryer 1 is based on the known to those skilled embodiments, the relevant, by patent applications and industrial property rights documented prior art freeze-dryers and in particular the embodiments of freeze-dryers , as these are the website www.martinchrist.de refer referenced.
  • a "freeze dryer” also includes a freeze-drying plant, in which (in contrast to the embodiments shown here), an automated loading and unloading takes place.
  • the housing 2 is basically opaque and electromagnetically shielded.
  • the housing 2 is basically made of stainless steel or at least equipped with a sheath and / or lining made of stainless steel.
  • the housing 2 has an opening 13, which is arranged here in the region of the product chamber 3 and over which the shelves 10 are accessible from the outside, so that via the opening 13 a (automated or manual) loading and unloading of the freeze dryer 1 is possible.
  • the opening 13 is (manually or automatically) closed by a door or flap 14.
  • the door or flap 14 forms a viewing window 15 through which the interior of the freeze dryer 1, here the interior of the product chamber 3, is visible and the footprint 10 with the products 11 are visible.
  • Fig. 1 an example of a door 14 is shown, which is pivotable about a vertical axis for opening and pressure-tight closing of the opening 13.
  • the door 14 has this an at least partially transparent viewing window 15, via which the interior of the product chamber 3 with the shelves 10 and the products 11 is visible from the outside.
  • a base body 16 of the door 14 is shown as a white surface, while a layer or coating 17 is shown as a black surface.
  • the base body 16 is formed with a transparent material (in particular inorganic glass or crystal glass or organic glass, in particular transparent plastic glass made of materials such as PMMA, PC, PET, SAN, PVC and the like, customary for such doors 14.
  • a transparent material in particular inorganic glass or crystal glass or organic glass, in particular transparent plastic glass made of materials such as PMMA, PC, PET, SAN, PVC and the like, customary for such doors 14.
  • the layer 17 may be molded onto the base body 16 (or vice versa), the layer 17 and the base 16 may be glued together or a coating 17 is glued to the base body 16 ,
  • the layer or coating 17 can also be formed with a woven, nonwoven, lacquer, a film or a film, a grid and / or a net.
  • the layer or coating 17 is applied to the inside of the door 14 on the base body 16 or connected on this side with the base body 16.
  • the main body 16 of the door 14 is provided both on the inside and on the outside with a layer or coating 17a, 17b.
  • the door on the outside and on the inside with a layer or a base body 16a, 16b formed, in which case the layer or coating 17 between the main bodies or layers 16a, 16b is arranged and preferably cohesively or via an adhesive with two basic bodies 16a, 16b is connected.
  • the material of the base body 16 of the door 14 is provided with an additive 18, in which it may be in the material of the base body 16 is not resolved, but may be stochastically distributed particles 19 act.
  • a concrete embodiment of a door 14 is shown.
  • the door 14 here has a viewing window 15, which is square with rounded corners.
  • the door 14 has a cover or a frame 20 (hereinafter also referred to as "cover 20"), which is preferably non-transparent.
  • cover 20 a cover or a frame 20
  • a closure mechanism 21 formed here with a lever can be seen, via which a gas-tight closed position of the door 14 can be brought about and secured.
  • the door 14 has in the lateral edge region via hinge elements 22, 23, via which the door 14 can be hinged to the housing 2 of the freeze dryer 1 to allow the pivoting of the door 14 about a vertical axis from the open position to the closed position and vice versa.
  • the main body 16 of the door 14 is formed with a glass pane 24, in particular made of transparent plastic glass and / or with a thickness in the range of 4 to 6 cm. At least in the region of the viewing window 15, the layer or coating 17 is applied on the outside to the glass pane 24.
  • the cover 20 is L-shaped. A leg 25 of the L is on the side on which the layer or coating 17 is disposed on the glass pane 24 at. The other leg 26 of the L is located on an outer end face 27 of the base body 16 (here the glass pane 24).
  • the leg 25 of the cover 20 forms on the outside of the door 14 surrounding the viewing window 15 and this outwardly bounding frame, while the leg 26 forms a kind of enclosure of the base body 16.
  • the cover 20 is formed in one piece, without this necessarily being the case.
  • the cover 20 is screwed by screws 28, 29 with the base body 16, wherein the screws 29 from the front of the door 14 vertical to the plane according to Fig. 6 are screwed into the base body 16 and the screws 28 are screwed vertically to the end faces 27 of the base body 16.
  • the leg 25 of the cover 20 overlaps the layer or coating 17, wherein a possible coating 17 may also be clamped between the leg 25 of the cover 20 and the base body 16 and / or the leg 25 of the cover 20, the edge region of the layering or coating 17 protects.
  • a possible coating 17 may also be clamped between the leg 25 of the cover 20 and the base body 16 and / or the leg 25 of the cover 20, the edge region of the layering or coating 17 protects.
  • Possible (deviating from the detail VIII according to Fig. 8 ) but also that the leg 25 of the cover 20 directly adjoins the layer or coating 17 without overlapping.
  • the shutter mechanism 21 and the hinge members 22, 23 are supported by the frame-shaped cover 20.
  • the base body 16 is held with layer or coating 17 via the screws 28, 29.
  • the frame or cover 20 is not integrally formed. Rather, here to form the cover or the frame 20 a plurality of segments 30a, 30b, 30c, 30d use.
  • the segments 30 are formed as U-profiles.
  • the base legs 31 of the segments 30 are each bolted to the associated end face 27 of the base body 16. Between the side legs 32, 33, the outer edge regions of the base body 16 are added.
  • the edge areas of the base body 16 received between the side legs 32, 33 are machined with the production of cutouts 34, 35 to the clear dimension between the side legs 32, 33, in particular with a clearance fit, press fit or transition fit.
  • the base body 16 is produced with a thickness having a relatively large tolerance, for example as a result of a casting process with tolerances of up to several millimeters.
  • the segments 30a, 30b and 30b, 30c form a miter.
  • the shutter mechanism 21 is supported by the segment 30b, while the hinge members 22, 23 may be supported by the segment 30d.
  • the base body 16 made of a transparent plastic glass with an addition 18. It is alternatively or cumulatively possible that the base body 16 is provided with a coating or layer 17.
  • the cover or frame 20 or segments 30 are preferably made of stainless steel.
  • any materials can be used, provided that they are at least partially transparent. PMMA, PET or PC or glass can be used here in particular.
  • a viewing window 15 may not be formed in a door or flap 14. Rather, for example, can also drying chamber containers, as can be seen from the Internet page www.martinchrist.de form the viewing window 15 and thus be equipped with a layer or coating 17 and / or an additive 18 to reduce the radiation transmission.
  • Fig. 12 shows a highly schematic of a further embodiment of a freeze dryer 1, in which the ice condenser chamber 4 is formed with a base module 36 which has a trough or cup-like housing 37 with arranged therein cooling device 12. On the housing, the necessary connections for pressurization and venting and generation of the vacuum are provided.
  • the housing 37 is open at the top.
  • On the housing 37 is under sealing by means of a sealing element 38, an intermediate plate 39th supported, which in particular in the region of a central through bore, the valve 6 has.
  • On the intermediate plate 39 is supported (in a manner not shown here), a frame with shelves 10a, 10b ... from.
  • the shelves 10 are received in a housing 40 open in the direction of the base module 36 and the intermediate plate 39.
  • the housing 40 is sealed by a sealing element 41 with respect to the intermediate plate 39.
  • the freeze dryer 1 is designed as a two-chamber freeze dryer, wherein the base module 36 forms the ice condenser chamber 4, while the housing 40 limits the product chamber 3 and a separation of the ice condenser chamber 4 and the product chamber 3 through the intermediate plate 39 and the valve 6 takes place.
  • the housing 37 is cuboidal or cylindrical, so that the in Fig. 12 illustrated cross section corresponding to an upside-down U results.
  • the housing 40 is in this case partially or preferably completely formed of inorganic glass or organic glass with the above-mentioned materials. In this case, the housing is formed with reduced radiation transmission, which by means of in Fig.
  • Fig. 13 shows a different embodiment of a freeze dryer 1, but in which the same basic module 36 is used as in Fig. 12 , In this case, no intermediate plate 39 and no U-shaped housing 40 is used. Rather, a lid 42 is supported by a sealing element 38 on the housing 37 of the basic module 36.
  • the lid 42 is made of any glass with the implementation of the previously described measures to reduce the radiation transmission.
  • the lid 42 is equipped on its outside with a coating 17.
  • the footprint 10 is located directly in the ice condenser chamber 4 and the product chamber 3 and the ice condenser chamber 4 are formed as an integral chamber, so that here is a single-chamber principle application.
  • Fig. 13 While according to Fig. 13 the footprint 10 in a manner not shown, for example via a frame, is supported directly on the housing 37, disclosed Fig. 14 an embodiment, in which likewise a single-chamber principle is used and the same basic module 36 is used as in the Fig. 12 and 13 , Again, a lid 42 is supported on the housing 37 via a sealing element 38 and suitable measures for reducing the radiation permeability of the lid 42 are taken. In this case, however, the footprint 10 is fixed to the cover 42, which can be done via struts 43, which, distributed over the circumference, extend from the edge of the footprint 10 in the vertical direction up to the cover 40.
  • the struts also include lines 44, which the supply and removal of measurement signals and / or for supplying electrical voltage for heating and / or cooling and / or the supply and / or discharge of a fluid for cooling and / or Heating the footprint 10 can serve.
  • This supply and / or supply and discharge can also take place via the cover 42, via the intermediate plate 39 or the housing 37.
  • the fixation of the housing 40, the intermediate plate 39 and the lid 42 to the housing 37 for the embodiment according to Fig. 12 to 14 on the pressure conditions so that automatically with the venting of the ice-condenser chamber 4 and / or the product chamber 3, the contact force between said components is increased and removal of the technical vacuum easy assembly and disassembly is possible. It is understood that any complementary connection and fastening measures can be taken. According to the embodiments according to Fig. 12 to 14 the housing 40 or the cover 42 forms the viewing window 15.
  • the arrangement of a layer or coating on an inner side of the viewing window is particularly advantageous if it is to be avoided that the electromagnetic radiation should pass from the interior of the housing of the freeze dryer to the outside. If, on the other hand, the coating or layer is arranged on the outside, the electromagnetic radiation propagates from the interior of the freeze dryer through the transparent plastic glass. In this case, it may be disadvantageous that the electromagnetic radiation is also transmitted to the edge region of the transparent plastic glass and there "bypasses" the coating or layer. In particular, in this case is advantageous if the front side of the transparent plastic glass is also equipped with a layer or coating.
  • no electromagnetic wave or microwave based heater is used in the freeze dryer.
  • an at least partially transparent or transparent layer or coating is also used in order to be able to observe changes in the product during the process progress.
  • the measures according to the invention influence reflection, absorption, emission and / or transmission, which on the one hand can apply to radiation from the inside to the outside and on the other hand to radiation from outside to inside.
  • the global radiation of the sun for example for the midday sun in the Mediterranean in the summer, has relative radiation intensities above 20% in the wavelength range UVA (315-380 nm), in the range of visible light (380-780 nm) and in the range infrared A (ER -A; 780-1400 nm).
  • the material used also reduces the radiation transmission for radiation in the wavelength range infrared B (IR-B, 1400-300 nm).
  • IR-B infrared B
  • a reduced radiation permeability can be brought about in one, several or all of the areas mentioned.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Drying Of Solid Materials (AREA)
EP15159161.7A 2015-03-16 2015-03-16 Lyophilisateur doté d'un hublot Active EP3070425B1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES15159161.7T ES2690269T3 (es) 2015-03-16 2015-03-16 Liofilizador con una ventanilla de visión
EP15159161.7A EP3070425B1 (fr) 2015-03-16 2015-03-16 Lyophilisateur doté d'un hublot
US15/071,307 US20160273835A1 (en) 2015-03-16 2016-03-16 Freeze Dryer with an Inspection Window
CN201610149650.1A CN105987583B (zh) 2015-03-16 2016-03-16 具有视窗的冻干机

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15159161.7A EP3070425B1 (fr) 2015-03-16 2015-03-16 Lyophilisateur doté d'un hublot

Publications (2)

Publication Number Publication Date
EP3070425A1 true EP3070425A1 (fr) 2016-09-21
EP3070425B1 EP3070425B1 (fr) 2018-08-15

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EP15159161.7A Active EP3070425B1 (fr) 2015-03-16 2015-03-16 Lyophilisateur doté d'un hublot

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US (1) US20160273835A1 (fr)
EP (1) EP3070425B1 (fr)
CN (1) CN105987583B (fr)
ES (1) ES2690269T3 (fr)

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CN107014188A (zh) * 2017-06-07 2017-08-04 成都璐城科技有限公司 一种农用节能干燥机
CN107024095A (zh) * 2017-06-07 2017-08-08 成都璐城科技有限公司 一种新型农用节能干燥机
EP3502604A1 (fr) 2017-12-21 2019-06-26 Martin Christ Gefriertrocknungsanlagen GmbH Capteur de produit de lyophilisation, ensemble de capteurs de produit de lyophilisation, récipient de séchage et procédé de fonctionnement d'un capteur de produit de lyophilisation

Families Citing this family (1)

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CN107036415A (zh) * 2017-06-07 2017-08-11 成都璐城科技有限公司 一种便携式农用节能干燥机

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EP1412686B1 (fr) 2001-07-27 2007-03-21 Steris GmbH Chambre pour dispositif de lyophilisation
DE102006019641B4 (de) 2005-04-28 2013-08-01 Martin Christ Gefriertrocknungsanlagen Gmbh Gefriertrocknungsanlage
DE102007049278B4 (de) 2007-10-12 2010-08-05 Gea Lyophil Gmbh Vorrichtungen zum Gefriertrocknen
CN201476471U (zh) * 2009-09-23 2010-05-19 上海共和真空技术有限公司 一种用于冻干机的有机溶媒回收装置
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CN203231613U (zh) * 2013-04-26 2013-10-09 黄昕亚 卧桶式水晶台面冻干机

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Publication number Priority date Publication date Assignee Title
CN107014188A (zh) * 2017-06-07 2017-08-04 成都璐城科技有限公司 一种农用节能干燥机
CN107024095A (zh) * 2017-06-07 2017-08-08 成都璐城科技有限公司 一种新型农用节能干燥机
EP3502604A1 (fr) 2017-12-21 2019-06-26 Martin Christ Gefriertrocknungsanlagen GmbH Capteur de produit de lyophilisation, ensemble de capteurs de produit de lyophilisation, récipient de séchage et procédé de fonctionnement d'un capteur de produit de lyophilisation

Also Published As

Publication number Publication date
US20160273835A1 (en) 2016-09-22
CN105987583A (zh) 2016-10-05
EP3070425B1 (fr) 2018-08-15
CN105987583B (zh) 2020-03-13
ES2690269T3 (es) 2018-11-20

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