EP2965897B1 - Machine à presser des comprimés et procédé de production et de pesage de comprimés - Google Patents

Machine à presser des comprimés et procédé de production et de pesage de comprimés Download PDF

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Publication number
EP2965897B1
EP2965897B1 EP15176126.9A EP15176126A EP2965897B1 EP 2965897 B1 EP2965897 B1 EP 2965897B1 EP 15176126 A EP15176126 A EP 15176126A EP 2965897 B1 EP2965897 B1 EP 2965897B1
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EP
European Patent Office
Prior art keywords
tablet
transferring
weighing
transferring element
tablets
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EP15176126.9A
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German (de)
English (en)
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EP2965897A1 (fr
Inventor
Fabrizio Salvatore CONSOLI
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IMA Industria Macchine Automatiche SpA
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IMA Industria Macchine Automatiche SpA
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
    • B30B11/08—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
    • B30B15/32—Discharging presses

Definitions

  • the present invention relates to tablet press machines for producing tablets, lozenges, pills, for example for pharmaceutical, food or chemical use, and in particular relates to a rotary tablet press machine provided with a weighing system of the produced tablets.
  • the invention also relates to a method for producing and weighing tablets, lozenges, pills.
  • the known rotary tablet press machines comprise a die plate rotating around a vertical axis and provided with a plurality of dies or cavities that are arranged angularly equidistant along a circumferential edge.
  • An upper punch and a lower punch which are vertically moved by eccentrics that are constituted by respective pressure rollers, are associated to each die.
  • the punches compress the powder or granular product that is inserted in the dies in a dosing station so as to form tablets.
  • the thus obtained tablets are extracted from the dies of the plate and conveyed to an exit chute.
  • the various phases for carrying out a tablet are performed during one rotation turn of the dies plate that rotates with continuous motion.
  • the powder product is a pharmaceutical or food product.
  • the tablets have to meet defined production requirements, such as size, hardness, porosity and weight.
  • weight checking of the tablets is necessary both for rejecting from the production the tablets that are out-of-spec because containing an exceeding or insufficient quantity of product with respect to a set quantity, and for adjusting possible excesses or defects in the dosing and compressing phases of the tablet press machine.
  • Indirect weight checking systems are known that measure the compression force that is exerted by the punches. Since the stroke of the latter ones inside the dies is predetermined, the compressing force is correlated to the amount of powder product in the dies. In particular, the compressing force proportionally increases with the amount of product that is contained in the dies. By measuring in real-time the compression forces and comparing the detected values with a reference value, it is thus possible to feedback control the product dosage so as to produce tablets having the desired weight.
  • the document US 7,471,992 discloses a similar weighing method.
  • the indirect checking systems enable to check the weight of all the tablets that are produced by the tablet press machine, but have the drawback of not ensuring the same measurement reliability and certainty of the direct checking systems.
  • the direct checking systems provide to use electronic scales comprising weighing or loading cells that are capable to directly weigh the tablets exiting from the compression table.
  • the scales enable to weigh with high precision and accuracy the tablets, but require for a reliable measurement a suitable weighing time, during which the tablets have to rest and be motionless on a measurement plane, or support, of the scale. In particular, a minimum time interval is required between dropping the tablet on the support and measuring the tablet weight, that is necessary for making stable the scale, i.e. for damping vibrations generated by placing the tablet on said scale.
  • the average weighing time substantially corresponds to the time required for the turret to rotate from half turn to a full turn.
  • the weighing systems with weighing scales have the drawback that they can be used only to execute a weight checking of statistical or partial type, which enables to weigh only a small part of the tablets produced by the machine.
  • a weight checking of statistical or partial type which enables to weigh only a small part of the tablets produced by the machine.
  • the known tablet press machines usually comprise control devices that are suitable to control the operating parameters of the compression process and/or the physical characteristics of the produced tablets in order to identify out-of-spec tablets, not compliant with the production requirement.
  • the control devices include indirect weighing devices or optical control devices.
  • Rejecting means is provided for rejecting the out-of-spec tablets according to signals that are received by the control devices.
  • the rejecting means typically includes blowing nozzles that are positioned on the die plate downstream of the compressing stations and arranged to push into a storage container the out-of-spec tablets once extracted from their respective dies.
  • blowing nozzles because of product powder inside the machine, are in fact subject to dirt and clogging and at high operating velocities cannot ensure a precise and reliable operation, with the risk to reject compliant products or not to reject out-of-spec products.
  • WO 2012/153283 discloses a rotary tablet press machine according to the preamble of claim 1 comprising a rotor, which is driveable about a vertical axis of rotation and has a die plate with die bores for producing tablets inside the die bores by means of punch pairs, at least one filling station, having at least one pressing station, and at least one tablet outlet for removing the produced tablets out of the rotary tablet press.
  • a discharging device is associated to the tablet outlet by way of which tablets, in dependence on a control signal, can be supplied as single tablets to a first channel or as a tablet stream to a second channel in the tablet outlet.
  • a weighing device with a weighing cell is incorporated into the tablet outlet, tablets from the first channel being suppliable to said weighing device by means of a supply channel.
  • US 2005/118260 discloses a method and apparatus for making a tablet product.
  • the method comprises closing off a perforation in a perforated plate, directing powder into said closed-off perforation by the sweeping action of a first director blade spaced from said perforated plate, compacting the powder to form a tablet and transferring the so-formed tablet from the closed-off perforation to a pocket blister of a blister strip.
  • the method provides a relative rotary motion of the perforated plate and the first director blade.
  • An object of present invention is to improve the known tablet press machines, in particular the tablet press machines provided with direct weight checking systems of the produced tablets.
  • Another object is to achieve a tablet press machine provided with a weighing system that enables to execute a total weight checking, i.e. to weigh all the produced tablets with high accuracy and precision.
  • a further object is to achieve a tablet press machine provided with a weighing system that enables to execute a weight checking in real-time and adjust in real-time the amount of product that is supplied to the dies.
  • a further object is to achieve a tablet press machine provided with a weighing system that enables to execute a statistical weight checking with high accuracy and precision on large number of tablets samples.
  • Still another object is to achieve a tablet press machine provided with a weighing system that is precise and reliable.
  • Another further object is to achieve a tablet press machine provided with simple and efficient rejecting means that enables to reject and eliminate in a precise and reliable manner the out-of-spec tablets.
  • a still further object is to provide a method for producing and weighing tablets that enables to execute with high accuracy and precision a total weight checking, i.e. to weigh all the produced tablets, or a statistical weight checking.
  • a tablet press machine is provided according to claim 1.
  • the rotary tablet press machine comprises a compression turret that rotates around a first axis with a constant angular velocity and is provided with a die plate having a plurality of dies and respective upper and lower compression punches for producing tablets and with weighing devices for weighing the tablets.
  • the machine also comprises transferring organs for transferring the tablets from the turret to the weighing devices and a control unit for driving and controlling said transferring organs.
  • the transferring organs comprise at least one transferring element, which is provided with at least one seat for a tablet and driven in rotation around an axis, controlled by said control unit, in a respective cycle time with a variable angular velocity so as to be, in succession, rotated in a first phase with an almost constant first angular velocity for drawing from the turret one tablet, rotated in a second phase with a variable second angular velocity for transferring the tablet towards the weighing devices, maintained stopped in a third phase for releasing the tablet to the weighing devices for weighing the latter and rotated in a fourth phase with a third angular velocity that is variable and increasing up to the first angular velocity, for bringing the transferring element back at the turret and drawing a successive tablet.
  • the transferring organs comprise a first transferring element and a second transferring element, each of which adapted to transfer at least one tablet from the turret to the weighing devices and independently driven in such a manner that, in an operating interval of the tablet press machine, the transferring elements concurrently draw at least one tablet from the compression turret and release a further tablet to the weighing devices.
  • the weighing devices comprise at least one, preferably at least two weighing cells for each seat of the transferring element.
  • the machine comprises deviating elements that are interposed between the transferring element and the weighing cells for directing a tablet coming from the seat at each turn of the transferring element alternately on one of the two weighing cells so as to have a weighing time, during which a weighing cell detects the weight of said tablet, that is substantially equal to said cycle time.
  • the transferring elements that are controlled by the control unit are capable to successively draw from the compressing turret all the tablets that are produced for a total weight checking. Furthermore, since the tablets are alternately released by the transferring elements to one of two weighing cells that are provided for each seat of the transferring elements, the weighing time available to the weighing cells enables the weighing cells to stabilize, i.e. to have an optimal damping of the vibrations generated by placing the tablet on the measurement plane of the said cells.
  • the tablet press machine of the invention to weigh in real-time with high precision and accuracy all the tablets that are produced.
  • Possible weight non-compliances of the tablets are communicated by the weighing devices to a further control and driving unit of the machine that can feedback control a filling device of the dies for varying the amount of product inside the dies, i.e. for varying the weight of the tablets.
  • the tablet press machine 1 further comprises control devices and rejecting devices that respectively enable to detect tablets that are out-of-spec, or non-compliant with the production requirements, and to reject said tablets.
  • the rejecting devices include deflectors that are arranged along supplying ducts of the weighing cells for deviating the out-of-spec tablets towards a rejection magazine, or to a rejection chute, that is arranged to receive out-of-spec tablets that are kept on the transferring elements and not released to the weighing cells.
  • Such rejecting devices operates with extreme precision and reliability and, compared to the traditional rejecting systems, ensure rejection of all the out-of-spec tablets even at high production velocity (rotation of the compression turret) of the tablet press machine.
  • the rotary tablet press machine 1 that is arranged to produce tablets, lozenges, pills comprises a compression turret 2, which is rotating around a first rotation axis X1 with constant angular velocity and includes a die plate 2a, which is provided with a plurality of dies 3 and respective compression means, such as a plurality of upper compression punches and a plurality of corresponding lower compression punches for producing tablets 100 by compressing a powder or granular product.
  • the first axis X1 is substantially vertical.
  • the machine 1 also comprises weighing devices 4 for weighing the tablets 100, transferring organs 10 for transferring the tablets 100 from the compression turret 2 to the weighing devices 4 and a control unit 50 for driving and controlling at least said transferring organs 10.
  • the transferring organs 10 comprise at least one transferring element 5, 6 that is provided with at least one seat 15 for a respective tablet 100 and driven in rotation around a second axis X2, controlled by the control unit 50, in a respective time cycle Tc with variable angular velocity so as to be, in succession, rotated in a first phase A1 with a first angular velocity ⁇ 1, which is almost constant, for drawing from the compression turret 2 at least one tablet 100, rotated in a second phase A2 with a second angular velocity, which is variable, for moving the tablet 100 towards the weighing devices 4, maintained stopped in a third phase A3 for releasing the tablet 100 to the weighing devices 4 in order to measure the weight and then rotated in a fourth phase A4 with a third angular velocity that is variable and increasing up to the first angular velocity ⁇ 1 to be brought back towards the turret 2 and to draw at least one successive tablet 100.
  • the second axis X2 is vertical and parallel to the first axis X1.
  • the cycle time Tc is the time that is required for the transferring element 5, 6 to execute an operating cycle, i.e. a complete turn around the second axis X2, and comprises the four successive operating phases A1, A2, A3, A4, which are better illustrated in the following description.
  • the transferring organs 10 comprise two transferring elements 5, 6, in particular a first transferring element 5 and a second transferring element 6, both rotating around the second axis X2 and controlled by the control unit 50, each transferring element being capable to transfer at least one tablet 100.
  • the two transferring elements 5, 6 are independently operated by respective actuating means, for example by respective brushless electric motors, or cam devices, that is controlled by the control unit 50 so that, in an operating interval Tf of the machine 1, said transferring elements 5, 6 are capable at the same time as to draw at least one tablet 100 from the compression turret 2 and release a further tablet 100 to the weighing devices 4.
  • respective actuating means for example by respective brushless electric motors, or cam devices
  • Each transferring element 5, 6 has a circular sector shape and is provided, on a peripheral edge, with at least one seat 15, 16 that is adapted to receive a tablet 100.
  • each transferring element 5, 6 is provided, on the respective peripheral edge, with a plurality of seats 15, 16, twelve in the illustrated embodiment, which are angularly spaced apart. In other words, in the operating interval Tf of the machine 1, a transferring element 5, 6 draws twelve tablets from the turret 2.
  • the weighing devices 4 comprise at least two weighing cells 11 for each seat 15, 16 of the transferring elements 5, 6, i.e. a number of weighing cells 11 that is equal to twice the number of seats 15, 16 of each transferring element 5, 6.
  • the tablet press machine 1 comprises deviating elements 17 that are interposed between the transferring elements 5, 6 and the weighing cells 11 and adapted to direct a tablet 100 coming from a seat 15, 16 at each turn of said gripping element 5, 6 alternately to one of the two respective weighing cells 11 so as to have a weighing time, during which a weighing cell 11 detects the weight of the tablet 100, that is substantially equal to the cycle time Tc, as better explained in the following description.
  • the transferring organs 10 comprise also a stationary abutment guide 12 that has a substantially annular shape, is coaxial with the second axis X2 and cooperates with the transferring elements 5, 6, more in particular with the seats 15, 16, for guiding the tablets 100 that are drawn from the compression turret 2 towards the weighing devices 4.
  • the tablet 100 resting on a respective lower compression punch, is deviated, with respect to a circular path around the first axis X1 by the guide abutment 12 along a further circular path around the second axis X2.
  • the tablet 100 is moved from the seat 15, 16 and guided by the guide abutment 12.
  • a fixed supporting plane 13 is provided underneath the transfer elements 5, 6 to support the tablets 100 in the transfer to the weighing devices 4 .
  • suction means can be provide for sucking dust and debris coming from the compression turret 2.
  • the supporting plane 13 has a plurality of releasing openings 13a in number that is equal to the number of the seats 15, 16 of each transferring element 5, 6, or in number that is equal to twice the number of seats 15, 16 of each transferring element 5, 6.
  • the releasing openings 13a are formed at openings of supplying ducts 14a, 14b of the weighing devices 4 that convey the tablets 100 to the below weighing cells 11.
  • a selecting device 20 of known type, for example a couple of levers that are adapted to transfer one tablet 100 at a time, is provided for each supplying duct 14a, 14b for transferring the tablets 100 on the respective weighing cells 11, and then, after the weighing time, pushing said tablets towards a below exit duct 21.
  • Further deviating elements 22 are provided inside the respective exit ducts 21 for directing in a rejection duct 23 the tablets 100, which are out-of-spec in weight and then to be rejected.
  • the supporting plane 13 has releasing openings 13a in a number that is equal to twice the number of seats 15, 16 of each transferring element 5, 6, which give access to first supplying ducts 14a and second supplying ducts 14b. In the shown embodiment, therefore, there are twenty-four releasing openings 13a, which give access to twelve first supplying ducts 14a and twelve second supplying ducts 14b.
  • the deviating elements 17 comprise a mobile plate that is slidable parallel to the supporting plane 13 so as to open the releasing openings 13a and, at each turn of the transferring elements 5, 6, directing alternately the tablets 100 into the first supplying ducts 14a or into the second supplying ducts 14b.
  • the releasing openings 13a are arranged circumferentially on the supporting plane 13.
  • the releasing openings 13a are also arranged in such a manner that the first supplying ducts 14a are alternated to the second supplying ducts 14b.
  • the transferring elements 5, 6 are adapted to transfer the tablets 100 at the releasing openings 13a, alternately of the first supplying ducts 14a and of the second supplying ducts 14b, such that, when the mobile plate is driven, the tablets 100 fall into the first supplying ducts 14a or into the second supplying ducts 14b.
  • Pushing pistons can be provided for pushing the tablets 100 downward into the supplying ducts 14a, 14b.
  • the deviating elements 17 and the releasing openings 13a are also shaped so as to rotate the tablets so that the latter ones enter into, and slide along, the supplying ducts 14a, 14b with "edgeways" orientation, i.e. with a respective central symmetry axis that is horizontally arranged. In this way, the transversal dimensions of the supplying ducts 14a, 14b are smaller and the weighing cells 11 can be arranged aligned and side by side at a smaller distance.
  • the weighing devices 4 comprise a weighing unit 7 that is provided with weighing cells 11 (in a number that is equal to twice the number of seats 15, 16 of each transferring element 5.6) that are arranged side by side and aligned.
  • Each weighing cell 11 is in communication with a respective releasing opening 13a through a respective (first or second) supplying duct 14a, 14b.
  • the operation of the tablet press machine 1 provides that the tablets 100, which are produced by the compression turret 2, are extracted from the dies 3 of the turret 2 by means of lifting means of known type and not illustrated in the figures, for example by means of the lower compression punches, are gripped at a drawing zone from the seats 15, 16 of the transferring elements 5, 6 and, by means of the abutment guide 12, are transferred to the releasing openings 13a.
  • each transferring element 5, 6 is moved by the control unit 50 with different angular velocities according to the four successive operating phases A1, A2, A3, A4 as illustrated in the diagram of figure 4 , which shows as the abscissae (time) the starting instants t1, t2, t3, t4 of the operating phases A1, A2, A3, A4 and as the ordinate (velocity) the angular velocities of each transferring element 5, 6.
  • Each transferring element 5, 6 in the respective cycle time Tc is, in succession, rotated in the first phase A1, having a first duration (t1-0), with the first angular velocity ⁇ 1 almost constant so as to draw the tablets 100 from the turret 2, rotated in the second phase A2, having a second duration (t2-t1), with a variable second angular velocity for transferring the tablets 100 from the turret 2 to the weighing devices 4, maintained stopped in the third phase A3, having a third duration (t3-t4), for releasing the tablets 100 to the weighing devices 4 and finally rotated in the fourth phase A4, having a fourth duration (t4-t3), with a third angular velocity that is variable and increasing up to the first angular velocity ⁇ 1.
  • each transferring element 5, 6 moves along a circular transferring path C1 (first pitch circle C1) at the same linear velocity with which the tablets 100 moves that are in the turret 2 and move along a circular compression path C2 (second pitch circle C2) that is tangent at a drawing point C3 to the circular transferring path C1.
  • each transferring element 5, 6 is capable to draw from the turret 2 a number of tablets 100 which is equal to the number of seats 15, 16 in the operating interval Tf of the machine 1 and go back, after another operating interval Tf of the machine 1, in drawing condition of further tablets 100 from the turret 2.
  • each transferring element 5, 6 is moved with variable angular velocity: in a first portion with increasing value (accelerated motion) and a second portion with a decreasing value (decelerated motion).
  • the rotational velocity in the second phase A2 is such as to reduce the second duration (t2-t1) to a minimum value that is necessary to the transferring element 5, 6 for moving the tablets 100 from the turret 2 to the weighing devices 4.
  • the deviating elements 17 are activated so as to direct the tablets 100 alternately into the first supplying ducts 14a or into the second supplying ducts 14b.
  • the transferring element 5, 6 is moved again, gradually accelerated during the fourth operating phase A4.
  • the two transferring elements 5, 6 rotate in an independent manner according to the same velocity profile that is divided into the four operating phases A1, A2, A3, A4, in particular temporally phase-shifted by a value that is equal to the first duration (t1-0) or equal to half of the cycle time Tc, as highlighted in the diagram of Figure 4 .
  • a transferring element for example the first transferring element 5
  • the other transferring element the second transferring element 6
  • the turret 2 In an operating interval Tf of the tablet press machine 1 with a duration that is equal to half of the cycle time Tc, the turret 2 produces a number of tablets 100 that is equal to the number of seats 15, 16 of the transferring elements 5, 6. In other words, in each operating interval Tf all the tablets 100 that are produced by the turret 2 are drawn alternately by the first transferring element 5 or by the second transferring element 6.
  • both transferring elements 5, 6 are capable to successively draw from the compression turret 2 the respective tablets 100, i.e. all the produced tablets 100 so as to allow a total or 100% weight checking.
  • the weighing time during which a weighing cell 11 detects the weight of the tablet 100, is substantially equal to the cycle time Tc, i.e. equal to twice the operating interval Tf of the machine 1.
  • the weighing devices 4 have at their disposal a weighing time that enables the weighing cells 11 to stabilize, i.e. such as to have an optimal damping of the vibrations that are generated by placing the tablet on the supporting plane of said cell.
  • the tablet press machine 1 of the invention to weigh with high precision and accuracy all the produced tablets 100.
  • the first transferring element 5 gives the tablets 100 to the weighing cells 11 that are supplied by the first supplying ducts 14a
  • the second transferring element 6 gives the tablets 100 to the weighing cells 11 that are supplied by second supplying ducts 14b.
  • the tablet press machine 1 therefore allows performing a total or 100% weight checking of the tablets, i.e. to weigh all the produced tablets, with high accuracy and precision, since the weighing time has a duration that is high and substantially equal to twice the operation interval Tf.
  • the arrangement of the tablets 100 with "edgeways" orientation in the supplying ducts 14a, 14b and on the weighing cells 11 also enables to reduce the overall dimensions of the weighing devices 4.
  • Figure 3 illustrates a variant of the tablet press machine 1 of the invention that differs from the above described embodiment that is illustrated in Figures 1 - 2A for the deviating elements 27 that rotate instead of translate as the deviating elements 17 of Figures 1-2A and for the weighing devices 4 that include two distinct weighing units 8, which are arranged side by side and opposite, each of which provided with a number of weighing cells 11 that is equal to the number of seats 15, 16 of each transferring element 5, 6.
  • the weighing cells 11 of a weighing unit 8 are supplied by the tablets 100 through first supplying conduits 24a, while the weighing cells 11 of the remaining weighing unit 8 are supplied by the tablets 100 through second supplying conduits 24b.
  • the first supplying conduits 24a form with the second supplying conduits 24b, in the shown embodiment, couples of supplying conduits that originate from a common releasing opening 13a.
  • the deviating elements 27 comprise, in the illustrated embodiment, a plurality of deflectors rotating around respective axes and capable to direct the tablets 100 released by the transferring elements 5, 6, and passing through the openings 13a of the supporting plane 13 alternately to the first supplying conduits 24a and to the second supplying conduits 24b.
  • first supplying conduits 24a and second supplying conduits 24b can originate from respective and distinct releasing openings 13a that are arranged circumferentially on an arc of the supporting plane 13.
  • the tablet press machine 1 also comprises a further control and driving unit, which is adapted to receive signals that are representative of the weight of the tablets 100 from the weighing devices 4 and to control, on the basis of these signals, a device for filling the dies 3 for changing the product amount inside the dies 3, i.e. for changing the weight of the tablets 100.
  • the further control and driving unit can be included and/or integrated in the control unit 50 that drives and controls the transferring organs 10.
  • the latter comprises control devices, of known type and not illustrated in the figures, that are arranged for controlling one or more operating parameters of the machine (compressing force of the product powders, height of a product dose) and/or characteristics of the produced tablets 100 (weight, humidity, presence of foreign bodies, etc.) in order to locate out-of-spec tablets 100', i.e. not-compliant with the production requirements.
  • the control devices are in fact capable to detect variations of the operating parameters and/or characteristics of the tablet and to emit corresponding signals for rejecting the out-of-spec tablets 100'.
  • control devices can be arranged on the compression turret 2 and comprise, for example, further weighing devices of indirect type.
  • the control devices can be positioned at the transferring organs and comprise, for example, optical control devices.
  • the tablet press machine 1 also comprises rejecting devices or means 30 that are arranged to reject the out-of-spec tablets 100' on the basis of rejection signals that are received by the control devices.
  • the rejecting devices 30 can be positioned upstream of the weighing devices 4.
  • said rejecting devices 30 can comprise respective deflecting elements 31 that are interposed between the transferring elements 5, 6 and the weighing cells 11, in particular along the supplying ducts 14a, 14b and arranged for directing the out-of-spec tablets 100' toward a rejection magazine 32.
  • the rejecting devices can comprise deviating pistons that are associated with the transferring elements 5, 6, or with the supporting plane 13, for rejecting the out-of-spec tablets do 100' before being supplied to the supplying ducts 14a, 14b.
  • the rejecting devices 30 can comprise a rejection chute 33 that is positioned downstream the releasing openings 13a for receiving the out-of-spec tablets 100' that are maintained on the transferring elements 5, 6 and not released by the deviating elements 17 to the weighing cells 11.
  • the deviating elements 17 are driven or not on the basis of the signals that are emitted by the control devices.
  • the out-of-spec tablets 100' are not supplied to the weighing cells 11 by means of the deviating elements 17 which do not open the supplying ducts 14a, so that such out-of-spec products 100' are transferred by the transferring elements 5, 6 to the rejection chute 33.
  • the above-described rejecting devices operates with extreme precision and reliability.
  • the above described rejecting devices guarantees the rejection of all the out-of-spec tablets even at high production velocity (rotation of the compression turret) of the tablet press machine 1.
  • a further variant of the tablet press machine 1 of the invention is provided that comprises only one transferring element 5 that, in the respective cycle time Tc, is controlled by the control unit 50 so as to be moved with different angular velocities according to the four operating phases A1, A2, A3, A4 illustrated in the diagram of Figure 5 , which illustrates as the abscissae (time) the starting instants t1, t2, t3, t4 of said operating phases A1, A2, A3, A4 and as the ordinate (velocity) the angular velocities of the transferring element 5.
  • the transferring element 5 is rotated in a first phase A1, having a first duration (t1-0), with a first angular velocity ⁇ 1 that is almost constant so as to draw the tablets 100 from turret 2, rotated in a second phase A2, having a second duration (t2-t1), with a variable second angular velocity for transferring the tablets 100 from the turret 2 to the weighing devices 4, maintained stopped in a third phase A3, having a third duration (t3-t2), for releasing the tablets 100 to the weighing devices 4, and then rotated in a fourth phase A4, having a fourth duration (t4-t3), with a third angular velocity that is variable and increasing up to the first velocity angular ⁇ 1.
  • This variant of the machine allows weighing only a part of the tablets 100 that are produced by the machine 1 and drawn in regular or random succession by the transferring element 5, i.e. to perform a so-called statistical weight checking.
  • the tablets 100 are released by the transferring element 5 alternately to one of two weighing cells 11 that are provided for each of the seats 15, i.e. alternately to the first supplying duct 14a or the second supplying duct 14b of the weighing devices. Since the weighing time is substantially equal to the cycle time Tc, also in this variant of the machine 1 the weighing devices 4 have at their disposal a weighing time that enables the weighing cells 11 to optimally stabilize for weighing the tablets 100 with high precision and accuracy. In particular, in this embodiment the time that is available for the weighing devices can be equal to twice the cycle time Tc by virtue of the presence of two weighing cells 11 for each seat 15 of the transferring element 5.
  • the two weighing cells 11 for each seat 15 enable the transferring element 5 to have a cycle time Tc that is not strictly linked to the weighing time, and then such as to enable to draw the tablets 100 from the compression turret 2 with a greater frequency.
  • the tablet press machine 1 enables to perform a statistical weight checking with high precision and accuracy and with a large number of samples of tablets 100. In the embodiment with only one transferring element 5, it is then possible to perform a statistical weight checking of up to 50% of the tablets 100.
  • the weighing devices 4 can provide a weighing unit that is provided with a number of weighing cells 11 that is equal to the number of the seats 15 of the transferring element 5.
  • the method according to the invention for producing and weighing tablets 100 for pharmaceutical, food or chemical use comprises the following steps:
  • the method also provides to transfer the tablets 100 from the compression turret 2 to the weighing devices 4 through a first transferring element 5 and a second transferring element 6 of the transferring organs 10, each of the transferring elements 5, 6 being adapted to transfer at least one tablet 100 from the compression turret 2 to the weighing devices 4.
  • the first transferring element 5 and the second transferring element 6 are independently operated in such a manner that in an operating interval Tf of the machine 1 the first transferring element 5 draws at least one tablet 100 from the compression turret 2 and at the same time as the second transferring element 6 releases at least one further tablet 100 to the weighing devices 4.

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Claims (15)

  1. Machine à presse rotative pour comprimés, incluant :
    - une tourelle de compression (2) rotative autour d'un premier axe (X1) avec une vitesse angulaire constante, incluant une plaque de matrices (2a) pourvue d'une pluralité de matrices (3) et d'une pluralité de poinçons de compression supérieurs et d'une pluralité correspondante de poinçons de compression inférieurs ;
    - des dispositifs de pesage (4) pour peser lesdits comprimés (100) ; et
    - des organes de transfert (10) pour transférer des comprimés (100) de ladite tourelle de compression (2) auxdits dispositifs de pesage (4) ;
    - une unité de commande (50) pour entraîner et commander lesdits organes de transfert (10) ;
    caractérisé en ce que lesdits organes de transfert (10) incluent au moins un élément de transfert (5, 6) pourvu d'au moins un logement (15, 16) pour un comprimé respectif (100) et entraîné de façon rotative autour d'un second axe (X2), commandé par ladite une unité de commande (50), dans un temps de cycle respectif (Tc) avec une variable de vitesse angulaire de manière telle à être, en succession, mis en rotation, dans une première phase (A1), avec une première vitesse angulaire (ω1) presque constante pour tirer, à partir de ladite tourelle de compression (2), au moins un comprimé (100), mis en rotation, dans une deuxième phase (A2), avec une deuxième vitesse angulaire variable pour transférer ledit comprimé (100) de ladite tourelle de compression (2) auxdits dispositifs de pesage (4), arrêté, dans une troisième phase (A3), pour libérer ledit comprimé (100) destiné à être pesé vers lesdits dispositifs de pesage (4), et mis en rotation, dans une quatrième phase (A4), avec une troisième vitesse angulaire qui est variable et augmente jusqu'à la première vitesse angulaire (ω1), pour être remis dans ladite tourelle de compression (2) et tirer un comprimé successif (100).
  2. Machine selon la revendication 1, dans laquelle lesdits dispositifs de pesage (4) incluent au moins deux cellules de pesage (11) pour chaque logement (15, 16) dudit au moins un élément de transfert (5, 6), ladite machine (1) incluant des éléments de déviation (17, 27) interposés entre ledit au moins un élément de transfert (5, 6) et lesdites au moins deux cellules de pesage (11) pour libérer un comprimé (100), provenant dudit au moins un logement (15, 16), à chaque tour dudit au moins un élément de transfert (5, 6), de façon alternée vers l'une desdites au moins deux cellules de pesage (11) afin d'avoir un temps de pesage, durant lequel ladite une desdites au moins deux cellules de pesage (11) détecte le poids dudit comprimé (100), qui est sensiblement égal audit temps de cycle (Tc) dudit au moins un élément de transfert (5, 6).
  3. Machine selon une quelconque revendication précédente, incluant en outre :
    - des dispositifs de contrôle pour contrôler des paramètres de fonctionnement de ladite machine (1) et/ou des caractéristiques desdits comprimés (100) et pour identifier un éventuel comprimé non conforme (100'), lesdits dispositifs de contrôle étant adaptés pour émettre un signal de rejet pour rejeter ledit comprimé non conforme (100') ; et
    - des moyens de rejet (30) adaptés pour recevoir ledit signal de rejet à partir desdits dispositifs de contrôle et pour rejeter ledit comprimé non conforme (100').
  4. Machine selon la revendication 3, dans laquelle lesdits moyens de rejet (30) incluent une goulotte de rejet (33) adaptée pour recevoir, à partir dudit au moins un élément de transfert (5, 6), un comprimé non conforme (100') qui est maintenu dans un logement respectif (15, 16) et non libéré vers les dispositifs de pesage (4).
  5. Machine selon la revendication 3, dans laquelle lesdits moyens de rejet (30) incluent des éléments de déflexion (31) agencés entre ledit au moins un élément de transfert (5, 6) et lesdites au moins deux cellules de pesage (11) pour envoyer un comprimé non conforme (100') provenant d'un logement respectif (15, 16) vers un magasin de rejet (32).
  6. Machine selon la revendication 3, dans laquelle lesdits moyens de rejet (30) incluent des pistons de déviation adaptés pour rejeter un comprimé non conforme (100') et associés audit au moins un élément de transfert (5, 6) et/ou à un plan de support (13) agencé en dessous dudit au moins un élément de transfert (5, 6) pour supporter lesdits comprimés (100) durant le transfert auxdits dispositifs de pesage (4).
  7. Machine selon une quelconque revendication précédente, dans laquelle ledit au moins un élément de transfert (5, 6) présente une forme d'un secteur circulaire et est pourvu, sur un bord périphérique, d'au moins un logement (15, 16) adapté pour recevoir un comprimé (100).
  8. Machine selon une quelconque revendication précédente, dans laquelle ledit au moins un élément de transfert (5, 6) est pourvu, sur un bord périphérique, d'une pluralité de logements (15, 16) espacés mutuellement les uns des autres de façon angulaire et lesdits dispositifs de pesage (4) incluent un nombre de cellules de pesage (11), le double du nombre desdits logements (15, 16).
  9. Machine selon une quelconque revendication précédente, dans laquelle lesdits organes de transfert (10) incluent un premier élément de transfert (5) et un second élément de transfert (6), dont chacun est adapté pour transférer au moins un comprimé (100) de ladite tourelle de compression (2) auxdits dispositifs de pesage (4), ledit premier élément de transfert (5) et ledit second élément de transfert (6) étant indépendamment entraînés et commandés par ladite unité de commande (50) pour que, dans un intervalle de fonctionnement (Tf) de ladite machine (1), ledit premier élément de transfert (5) tire au moins un comprimé (100) à partir de ladite tourelle de compression (2) et simultanément ledit second élément de transfert (6) libère un comprimé supplémentaire (100) vers lesdits dispositifs de pesage (4).
  10. Machine selon la revendication 9, dans laquelle ledit intervalle de fonctionnement (Tf) présente une durée sensiblement égale à une moitié de la durée dudit temps de cycle (Tc).
  11. Machine selon une quelconque revendication précédente, dans laquelle lesdits dispositifs de pesage (4) incluent une unité de pesage (7) pourvue d'au moins deux cellules de pesage (11), agencées côte à côte et alignées, pour chaque logement (15, 16) dudit au moins un élément de transfert (5, 6).
  12. Machine selon une quelconque revendication précédente, dans laquelle lesdits dispositifs de pesage (4) incluent deux unités de pesage (8), chacune étant pourvue d'une cellule de pesage (11) pour chaque logement (15, 16) dudit au moins un élément de transfert (5, 6).
  13. Machine selon une quelconque revendication précédente, dans laquelle ledit premier axe (X1) est parallèle audit second axe (X2).
  14. Procédé pour produire et peser des comprimés (100), comprenant les étapes suivantes :
    - la production d'une pluralité de comprimés (100) dans une machine à presse rotative pour comprimés (1) ;
    - le déplacement de ladite pluralité de comprimés (100) le long d'un chemin de compression circulaire (C2) de ladite machine à presse pour comprimés (1) ;
    - l'agencement d'au moins un élément de transfert (5, 6) d'organes de transfert (10) de ladite machine à presse pour comprimés (1), qui est pourvu d'au moins un logement (15, 16) pour un comprimé respectif (100), le long dudit chemin de compression circulaire (C2) ;
    - l'entraînement en rotation dudit élément de transfert (5, 6) qui est pourvu du logement (15, 16) pour que ce dernier soit déplacé le long d'un chemin de transfert circulaire (C1) dans un temps de cycle respectif (Tc) comprenant quatre phases (A1, A2, A3, A4) ;
    - le tirage, dans une première phase (A1), dans un point de tirage (C3), de tangence dudit chemin de compression circulaire (C2) et dudit chemin de transfert circulaire (C1), d'au moins un comprimé (100) au moyen dudit élément de transfert (5, 6) qui est pourvu de l'au moins un logement (15, 16), durant ledit tirage, dans ladite première phase (A1), ledit élément de transfert (5, 6) étant mis en rotation avec une première vitesse angulaire (ω1) presque constante ;
    - le transfert, dans une deuxième phase (A2), le long dudit chemin de transfert circulaire (C1), dudit au moins un comprimé (100), du point de tirage (C3) à des dispositifs de pesage (4), durant ledit transfert, dans ladite deuxième phase (A2), ledit élément de transfert (5, 6) étant mis en rotation avec une deuxième vitesse angulaire variable ;
    - l'arrêt dudit élément de transfert (5, 6), dans une troisième phase (A3), et la libération dudit comprimé auxdits dispositifs de pesage (4) ;
    - le pesage dudit au moins un comprimé (100) dans lesdits dispositifs de pesage (4) ;
    - l'entraînement en rotation, dans une quatrième phase (A4), dudit élément de transfert (5, 6) le long dudit chemin de transfert circulaire (C1), desdits dispositifs de pesage (4) audit point de tirage (C3), avec une troisième vitesse angulaire qui est variable, en particulier augmente jusqu'à ladite première vitesse angulaire (ω1).
  15. Procédé selon la revendication 14, dans lequel il est prévu, pour transférer lesdits comprimés (100) de ladite tourelle de compression (2) auxdits dispositifs de pesage (4), un premier élément de transfert (5) et un second élément de transfert (6) desdits organes de transfert (10), chacun desdits éléments de transfert (5, 6) étant adapté pour transférer au moins un comprimé (100) de ladite tourelle de compression (2) auxdits dispositifs de pesage (4), ledit premier élément de transfert (5) et ledit second élément de transfert (6) étant entraînés indépendamment pour que, dans un intervalle de fonctionnement (Tf) de ladite machine (1), ledit premier élément de transfert (5) tire au moins un comprimé (100) à partir de ladite tourelle de compression (2) et simultanément ledit second élément de transfert (6) libère au moins un comprimé supplémentaire (100) vers lesdits dispositifs de pesage (4).
EP15176126.9A 2014-07-10 2015-07-09 Machine à presser des comprimés et procédé de production et de pesage de comprimés Active EP2965897B1 (fr)

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EP3466664B1 (fr) * 2017-10-06 2022-12-14 Kikusui Seisakusho Ltd. Dispositif de déchargement de produits moulés
IT202100010685A1 (it) * 2021-04-28 2022-10-28 Ima Spa Macchina comprimitrice rotativa per la produzione di prodotti pressati.

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SU861105A1 (ru) * 1979-10-30 1981-09-07 Ждановский Филиал Специального Проектного Конструкторского Бюро Медицинской Промышленности Роторна таблеточна машина
IT1238959B (it) * 1990-05-21 1993-09-17 Ima Spa Dispositivo per il prelevamento ed il convogliamento di compresse in uscita da una macchina comprimitrice.
JP2000271794A (ja) * 1999-03-26 2000-10-03 Sumitomo Heavy Ind Ltd 回転式粉末圧縮成形機の製品排出装置
GB0207767D0 (en) * 2002-04-04 2002-05-15 Glaxo Group Ltd Method and apparatus for making a tablet product
DE102006017196B4 (de) 2006-04-12 2008-09-11 Fette Gmbh Verfahren zur Regelung der Wirkstoffmenge von Tabletten während der Produktion in einer Rundläufertablettenpresse
JP5085668B2 (ja) * 2010-02-02 2012-11-28 株式会社畑鉄工所 粉末圧縮成型品取出し装置及びこの装置を備えた回転式粉末圧縮成型装置
IT1401415B1 (it) * 2010-08-20 2013-07-26 Ima Spa Sistema e metodo per pesare articoli
DE102011050290B4 (de) * 2011-05-11 2013-11-07 Ima Kilian Gmbh & Co.Kg Rundläufer-Tablettenpresse mit Tablettenablauf, Tablettenablauf hierfür, Wiegeeinrichtung hierfür und Verfahren zum Herstellen von Tabletten auf einer Tablettenpresse

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