EP2897520A1 - Dispositif et procédé permettant la caractérisation de tissus - Google Patents

Dispositif et procédé permettant la caractérisation de tissus

Info

Publication number
EP2897520A1
EP2897520A1 EP13771041.4A EP13771041A EP2897520A1 EP 2897520 A1 EP2897520 A1 EP 2897520A1 EP 13771041 A EP13771041 A EP 13771041A EP 2897520 A1 EP2897520 A1 EP 2897520A1
Authority
EP
European Patent Office
Prior art keywords
tissue
stimulation
infrared
inspection head
modulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP13771041.4A
Other languages
German (de)
English (en)
Inventor
Nils Reinke
Andreas FASTRICH
Mathias BONMARIN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dermolockin GmbH
Original Assignee
Dermolockin GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dermolockin GmbH filed Critical Dermolockin GmbH
Publication of EP2897520A1 publication Critical patent/EP2897520A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • A61B5/015—By temperature mapping of body part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0077—Devices for viewing the surface of the body, e.g. camera, magnifying lens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/444—Evaluating skin marks, e.g. mole, nevi, tumour, scar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7228—Signal modulation applied to the input signal sent to patient or subject; demodulation to recover the physiological signal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient ; user input means
    • A61B5/742—Details of notification to user or communication with user or patient ; user input means using visual displays
    • A61B5/7445—Display arrangements, e.g. multiple display units

Definitions

  • the invention relates to a device and a method for characterizing tissue, in particular skin lesions, according to the independent claims.
  • Methods for characterizing tissue are known in many fields of technology. For example, such methods are used in the characterization of skin to detect skin lesions. So far, in this area, the methods have been limited to a visual examination of the skin. This method is subjective and a diagnosis of skin lesions, such as after a visual characterization of the skin, ie after a subdivision of the skin into areas with different properties, such as e.g. Cancer cell areas, highly depends on the experience of the respective doctor.
  • Active thermography is based on heating or cooling of a sample to be examined Tissue area and on a subsequent spatially resolved recording of the surface temperature of the tissue.
  • the heating or cooling generates a non-stationary temperature gradient within the tissue to be examined, which in turn influences the distribution of the surface temperature.
  • thermo-physical properties compared to its environment, e.g. a different density, heat capacity, thermal conductivity, etc., this area influences the heat flow and consequently the time-dependent surface temperature.
  • this area influences the heat flow and consequently the time-dependent surface temperature.
  • By monitoring the time-dependent surface temperature it is therefore possible to detect areas with different thermo-physical properties below the surface.
  • active thermography the object under investigation is heated by conduction, convection or absorption or cooled by conduction or convection.
  • the energy transfer can be continuous or periodic.
  • the principles of active thermography can be found e.g. in the document "Infrared thermal imaging" by M. Vollmer and K. P. Möllmann, Wiley-VCH, 2010.
  • WO 2010065052 A1 discloses a medical diagnostic system in which the skin surface is cooled by supplying cold air for a maximum of one minute.
  • a high-sensitivity stationary InSb infrared camera records the thermal behavior of the skin after thermal stimulation. After a post-processing of the infrared images for compensation By moving the patient, the time-dependent temperature of the skin is calculated and the result compared with a computer model for heat transfer. It has been shown that the thermal signature of melanoma is very different from that of healthy tissue or benign melanocytic nevi. Furthermore, it has been found that the main thermo-physical parameter affecting thermal behavior is blood perfusion, the other parameters mentioned above playing a rather minor role.
  • the device for characterizing tissue, in particular skin lesions, characterized in that the device comprises a stimulation device for thermal stimulation of the tissue, a modulation device for modulating the temperature of the tissue, an infrared camera for detecting modulated infrared images, with the arithmetic unit connected to the infrared camera for demodulating the modulated infrared images and a display module for displaying the images demodulated by the arithmetic unit.
  • the modulation device and the infrared camera are synchronized in such a way that a modulated infrared radiation emitted by the tissue can be detected by means of the infrared camera during the thermal stimulation of the tissue.
  • a portable inspection head is placed on the fabric. Subsequently, the thermal stimulation is applied to the tissue by means of the stimulation device and the image capture of the infrared camera is activated. Thereafter, a frequency of image acquisition with the
  • Modulation frequency of the modulation device synchronized and detected modulated infrared images by means of the infrared camera.
  • the modulated infrared images are then demodulated by means of the arithmetic unit and the demodulated infrared images are displayed on the display module.
  • the modulated infrared images of tissue-emitted, modulated infrared radiation are detected during thermal stimulation.
  • the device according to the invention By means of the device according to the invention and the method according to the invention, it is possible to obtain considerably more precise results of the tissue behavior in the stimulation with heat, since the behavior of the tissue is recorded directly during the stimulation and the time-dependent temperature patterns obtained thereby can be much better correlated with the stimulation pattern , The present device is therefore more sensitive than previous solutions.
  • the infrared camera is disposed within a portable inspection head, which is placed on the fabric.
  • the inspection head comprises at least one channel for supplying the thermal stimulation to the tissue.
  • the stimulation device and / or the modulation device are designed for periodic stimulation or modulation of the temperature of the tissue. This considerably increases the sensitivity of the measurements or the evaluation of the measurement results.
  • Figure 2 shows a first embodiment
  • Figure 3 shows a second embodiment
  • Figure 4 shows a third embodiment
  • FIG. 1 shows an embodiment of the device 1 according to the invention. It comprises a stimulation device for thermal stimulation of a tissue 8.
  • the stimulation device comprises an air conditioner 3 for producing an air flow guided onto the tissue 8 as thermal stimulation.
  • the device 1 comprises a modulation device 4 for modulating the temperature of the air flow and thus of the tissue 8.
  • the air conditioner 3 is connected to the modulation device 4 for modulation of the air flow.
  • the modulation ⁇ device 4 is arranged at the air outlet of the air conditioner 3.
  • the modulation device 4 can be arranged in an inspection head 2 to be described in more detail, which can be placed on the fabric.
  • the air conditioner 3 is connected by means of at least one flexible, thermally insulated hose 7 with the at least one channel of the inspection head 2.
  • the inspection head 2 includes at least one channel for delivering thermal stimulation to the tissue 8.
  • An infrared camera 14 is disposed within the portable inspection head 2.
  • the infrared camera 14 is connected via a data cable 10c to a computing unit 5 for demodulation of the modulated infrared images.
  • the arithmetic unit 5 is the output side with a display module 6 for the representation of the arithmetic unit demodulated images IIa, IIb connected.
  • a control unit 9 serves to control the modulation device 4 to generate the desired periodic stimulation.
  • a cable 10b It is connected on the one hand via a cable 10b to the arithmetic unit 5 for receiving therefrom a user-defined type of modulation in the form of digital signals, and on the other hand to the modulating device 4 for supplying an electrical signal for the generation of periodic modulation in the modulating device 4 to transfer these.
  • Fig. 2 shows a first embodiment of the inspection head 2, which is in contact with a fabric 8. It comprises in a housing 2a a channel 13 for supplying the periodic, modulated, thermal stimulation 12a, via the tube 7 of FIG. 1 from the air conditioner 3 in conjunction with the
  • the channel 13 carries the thermal stimulation 12a on the tissue 8, wherein the thermal stimulation 12a escapes after contact with the tissue through an evacuation port 17, which is shown by the arrows 12c.
  • hot or cold gas can escape from the interior of the inspection head 2, so that it does not heat up unnecessarily.
  • Part of the heat is taken up by the fabric 8 and emitted from the fabric surface 8a towards the camera 14, which is indicated by the arrows 12b.
  • the infrared camera 14, which is in particular a microbolometer camera or a semiconductor-based infrared camera 14 or a QWIP camera, records the time-dependent thermal radiation 12b of the tissue 8 or the tissue surface 8a via the objective 15.
  • the infrared camera 14 is isolated in its radiation detection range by means of a window 16 from the environment, the window 16 is transparent to the radiated from the fabric 8, modulated infrared radiation 12b.
  • the window 16 is between the lens 15 and the fabric 8 arranged and serves on the one hand as a filter for the radiation 12b and on the other hand as protection of the infrared camera 14 against dust and against the thermal stimulation 12a.
  • the window 16 may be made of an infrared transparent material.
  • the infrared camera 14 converts the thermal emission or radiation 12b of the tissue 8 or the tissue surface 8a into infrared images at a defined image rate.
  • the modulated infrared images are transmitted via the cable 10c from FIG. 1 to the arithmetic unit 5 and digitally demodulated there. Alternatively, a wireless transmission of images via Bluetooth or WLAN is possible.
  • the infrared images are demodulated according to the lock-in principle.
  • the lock-in thermography is known and is therefore not explained here. This results in a phase image IIa and an amplitude image IIb for each infrared image (see FIG.
  • images IIa, IIb characterize the tissue 8 or its thermal behavior as a result of the periodic stimulation 12a and are displayed on the display device 6 as grayscale or pseudocolor images.
  • images IIa, IIb zones with abnormal phase or amplitude values can then be identified as possible lesions.
  • the amplitude image IIb represents the temperature variations on the tissue surface 8a and the phase IIa shows a representation of the phase shift between the modulation signal and the time-dependent
  • phase and amplitude images IIa, IIb can be correlated with the localized thermo-physical properties of the tissue. Due to the averaging properties of the lock-in
  • Thermography can be achieved a significantly better sensitivity in image processing. For example, temperature differences of less than 1 mK can be detected. In comparison, at conventional static temperature measurements only sensitivities of about 17 mK can be achieved.
  • Another advantage is the intrinsic insensitivity of parameters such as a variation in the emissivity of the tissue, nonhomogeneous heating / cooling of the tissue, unwanted reflections from other infrared sources, etc.
  • the modulation frequency is chosen high enough, eg in the range of ImHz-lkHz, Lock-in thermography can suppress lateral heat diffusion from the demodulated images IIa, IIb, so that a more precise localization of the lesion and detection of the lesion margin becomes possible.
  • Modulation frequency includes the inspection head 2 means not shown in the figures for changing the modulation and / or the intensity of the thermal stimulation by the user. These can be, for example, means for inputting parameters and means for transmitting adjusted parameters to the arithmetic unit, which then sends the modulation of the temperature of the air flow (stimulation) 12a via the line 10b to the control unit 9 by means of suitable software. This digital signal is converted by the control unit 9 into a periodically modulated voltage, with the aid of which a heating element explained below is heated.
  • the temperature-modulated air flow 12a is generated by the air conditioner 3 and the modulation device 4.
  • the air conditioner generates air at constant speed and temperature, which are freely adjustable.
  • the air conditioner 3 comprises at least one electromagnetic source for thermal stimulation of the tissue, in particular an infrared source.
  • the infrared source generates infrared radiation, in particular with a wavelength in the range of 0.1 to 15 ⁇ m.
  • the electromagnetic source in this case preferably an infrared lamp, arranged in the channel 13 of the inspection head 2, whereby the air conditioner 3 is omitted.
  • the modulation device 4 is located in the channel 13 of the inspection head 2, between the electromagnetic source and the tissue 8.
  • the modulation device 4 heats the air coming from the air conditioner 3 periodically.
  • the modulation device 4 comprises an electrical circuit comprising arranged in the emission direction of the air conditioner 3, above-mentioned heating element which may be an electrical resistance, which is not shown.
  • a voltage applied to the resistor can be varied by means of the control unit 9 in such a way that the temperature of the tissue that can be changed by the thermal stimulation can be modulated.
  • the resistor is disposed in a tube, not shown, wherein the tube is positioned in the airflow 12a such that this airflow passes the resistor. When a voltage is applied to the resistor, resulting in the heating of the resistor, the air passing by is also heated.
  • a periodically modulated temperature of the air flow is achieved.
  • the modulation amplitude is chosen to set the minimum and maximum airflow temperatures. The greater the modulation amplitude, the greater the temperature gradient in the tissue 8 and the greater the time-dependent thermal signal (radiation).
  • the maximum temperature is chosen so that the tissue temperature does not exceed 42 ° C during the measurement. It is further advantageous to keep the minimum temperature above the dew point of water, so that no undesirable condensation effects occur.
  • the thus modulated air flow is sent via the flexible hose 7 to the inspection head 2 and enters the channel 13 of the inspection head 2 a.
  • the inspection head 2 is designed such that the thermal stimulation takes place without touching the tissue by the stimulation and the modulation device.
  • only one bearing surface of an outer housing of the inspection head 2 touches the tissue surface 8a.
  • the support surface is formed by exchangeable support modules, which are not shown here, with contour adaptable to curvatures of the tissue surface.
  • silicone can be used for these bearing surfaces, which is known to have a flexible structure.
  • FIG. 3 shows a second embodiment of the inspection head 2.
  • This embodiment corresponds to that of FIG. 2 with the difference that the evacuation opening 17 is not arranged laterally of the camera in the vicinity of the support surface, but behind the camera and parallel to the channel 13.
  • the stimulation device 3 is arranged in the channel 13. It can be an infrared lamp in this case.
  • the modulation device 4 is arranged in the emission direction of the infrared lamp, ie in the current of the thermal stimulation 12a between the stimulation device 3 and the tissue 8.
  • This arrangement also in the embodiment of FIG. 2 and for the still to be explained embodiment of FIG Use come. Such an arrangement has the advantage that the flexibility of the device is increased because no stationary air conditioner is needed.
  • 4 shows a third embodiment of the inspection head 2, which in this case has two channels 13a and two lateral evacuation openings 17a arranged in the region of the support surface.
  • the modulated thermal stimulation is introduced simultaneously through both channels into the inspection head 2.
  • a suitable embodiment of the inspection head 2 can be selected. This can e.g. depending on the nature of the tissue area or tissue surface to be examined. For example, if the tissue has one or more bends, the third embodiment of the inspection head 2 may be advantageous because the thermal stimulation comes from two directions and more uniformly stimulates the tissue at the bend. In the first embodiment, the air flow comes from one direction only, so that on one side of the curve there would be a "slipstream side" stimulated less than the airflow-facing side, which would result in greater inaccuracy of measurement To generate as laminar a flow as possible in order to stimulate a uniform stimulation of the whole
  • a suitable inspection head 2 as a function of

Abstract

L'invention concerne un dispositif et un procédé permettant la caractérisation de tissus, en particulier de lésions cutanées. Le dispositif comprend un dispositif de stimulation servant à la stimulation thermique des tissus, un dispositif de modulation servant à moduler la température des tissus, une caméra infrarouge servant à enregistrer des images infrarouges modulées, une unité de calcul connectée à la caméra infrarouge et servant à démoduler les images infrarouges modulées, et un module d'affichage servant à représenter les images démodulées par l'unité de calcul. Le dispositif de modulation et la caméra infrarouge sont synchronisés de telle manière qu'un rayonnement infrarouge modulé émis par les tissus peut être enregistré pendant la stimulation thermique des tissus au moyen de la caméra infrarouge.
EP13771041.4A 2012-09-18 2013-09-17 Dispositif et procédé permettant la caractérisation de tissus Withdrawn EP2897520A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH01684/12A CH706988A1 (de) 2012-09-18 2012-09-18 Vorrichtung und Verfahren zur Charakterisierung von Gewebe.
PCT/CH2013/000165 WO2014043822A1 (fr) 2012-09-18 2013-09-17 Dispositif et procédé permettant la caractérisation de tissus

Publications (1)

Publication Number Publication Date
EP2897520A1 true EP2897520A1 (fr) 2015-07-29

Family

ID=49293401

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13771041.4A Withdrawn EP2897520A1 (fr) 2012-09-18 2013-09-17 Dispositif et procédé permettant la caractérisation de tissus

Country Status (3)

Country Link
EP (1) EP2897520A1 (fr)
CH (1) CH706988A1 (fr)
WO (1) WO2014043822A1 (fr)

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US11122243B2 (en) 2018-11-19 2021-09-14 Flightsafety International Inc. Method and apparatus for remapping pixel locations

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US20040243021A1 (en) * 2001-11-06 2004-12-02 Murphy John C. Device for thermal stimulation of small neural fibers
US7985072B2 (en) * 2004-09-29 2011-07-26 Rejuvedent Llc Method and apparatus for tooth rejuvenation and hard tissue modification
JP2009501579A (ja) * 2005-07-18 2009-01-22 マンデリス，アンドレアス 赤外光熱放射測定（ｐｔｒ）および被変調レーザルミネセンス（ｌｕｍ）を使用して歯の欠陥を診断する方法および装置
WO2008103918A1 (fr) * 2007-02-22 2008-08-28 Wisconsin Alumni Research Foundation Spectromètre à imagerie pour la détection précoce du cancer de la peau
US8463006B2 (en) * 2007-04-17 2013-06-11 Francine J. Prokoski System and method for using three dimensional infrared imaging to provide detailed anatomical structure maps
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11122243B2 (en) 2018-11-19 2021-09-14 Flightsafety International Inc. Method and apparatus for remapping pixel locations

Also Published As

Publication number Publication date
CH706988A1 (de) 2014-03-31
WO2014043822A1 (fr) 2014-03-27

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