EP2831237A4 - Polymères d'héparosane de poids moléculaire élevé et procédés de production et d'utilisation de ceux-ci - Google Patents

Polymères d'héparosane de poids moléculaire élevé et procédés de production et d'utilisation de ceux-ci

Info

Publication number
EP2831237A4
EP2831237A4 EP13767739.9A EP13767739A EP2831237A4 EP 2831237 A4 EP2831237 A4 EP 2831237A4 EP 13767739 A EP13767739 A EP 13767739A EP 2831237 A4 EP2831237 A4 EP 2831237A4
Authority
EP
European Patent Office
Prior art keywords
production
methods
molecular weight
high molecular
heparosan polymers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP13767739.9A
Other languages
German (de)
English (en)
Other versions
EP2831237B1 (fr
EP2831237A1 (fr
Inventor
Paul L Deangelis
Philip Pummill
Regina C Vissier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Oklahoma
Original Assignee
University of Oklahoma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Oklahoma filed Critical University of Oklahoma
Priority to PL13767739T priority Critical patent/PL2831237T3/pl
Publication of EP2831237A1 publication Critical patent/EP2831237A1/fr
Publication of EP2831237A4 publication Critical patent/EP2831237A4/fr
Application granted granted Critical
Publication of EP2831237B1 publication Critical patent/EP2831237B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Birds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polymers & Plastics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
EP13767739.9A 2012-03-30 2013-03-29 Polymères d'héparosane de poids moléculaire élevé et procédés de production et d'utilisation de ceux-ci Active EP2831237B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL13767739T PL2831237T3 (pl) 2012-03-30 2013-03-29 Polimery heparosanu o wysokiej masie cząsteczkowej i sposoby ich wytwarzania i zastosowania

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261617952P 2012-03-30 2012-03-30
PCT/US2013/034631 WO2013149161A1 (fr) 2012-03-30 2013-03-29 Polymères d'héparosane de poids moléculaire élevé et procédés de production et d'utilisation de ceux-ci

Publications (3)

Publication Number Publication Date
EP2831237A1 EP2831237A1 (fr) 2015-02-04
EP2831237A4 true EP2831237A4 (fr) 2016-04-13
EP2831237B1 EP2831237B1 (fr) 2017-11-29

Family

ID=49235840

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13767739.9A Active EP2831237B1 (fr) 2012-03-30 2013-03-29 Polymères d'héparosane de poids moléculaire élevé et procédés de production et d'utilisation de ceux-ci

Country Status (10)

Country Link
US (5) US8980608B2 (fr)
EP (1) EP2831237B1 (fr)
AU (1) AU2013237894B2 (fr)
BR (1) BR112014024291B1 (fr)
CA (1) CA2869128C (fr)
DK (1) DK2831237T3 (fr)
ES (1) ES2661575T3 (fr)
PL (1) PL2831237T3 (fr)
TR (1) TR201802761T4 (fr)
WO (1) WO2013149161A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8580290B2 (en) * 2001-05-08 2013-11-12 The Board Of Regents Of The University Of Oklahoma Heparosan-based biomaterials and coatings and methods of production and use thereof
US9925209B2 (en) 2008-03-19 2018-03-27 The Board Of Regents Of The University Of Oklahoma Heparosan-polypeptide and heparosan-polynucleotide drug conjugates and methods of making and using same
US9687559B2 (en) 2008-03-19 2017-06-27 The Board Of Regents Of The University Of Oklahoma Heparosan polymers and methods of making and using same for the enhancement of therapeutics
BR112014024291B1 (pt) 2012-03-30 2022-07-05 The Board Of Regents Of The University Of Oklahoma Método para a produção de forma recombinante de um polímero de heparosan com alto peso molecular, uso do referido polímero para aumento de tecido, polinucleotídeo isolado e composição de material biológico compreendendo o referido polímero
AR099900A1 (es) * 2014-04-01 2016-08-24 Merz Pharma Gmbh & Co Kgaa Rellenos para tejidos blandos con polisacáridos con persistencia mejorada, kit, procedimiento, uso
US20160114050A1 (en) * 2014-10-23 2016-04-28 The Board Of Regents Of The University Of Oklahoma Heparosan/Therapeutic Prodrug Complexes and Methods of Making and Using Same
CN105602980B (zh) * 2016-01-25 2019-02-01 浙江工业大学 一种waaR基因缺陷型细菌合成低分子量肝素前体的方法
KR102427948B1 (ko) 2016-03-04 2022-08-02 모르포시스 아게 다발성 골수종에서 m-단백질 반응의 임상 평가
JP2022523638A (ja) 2019-01-15 2022-04-26 オプティムヴィア、エルエルシー 改変型硫酸アリール依存性酵素
EP3997238A1 (fr) 2019-07-09 2022-05-18 Optimvia, LLC Procédés de synthèse de polysaccharides anticoagulants

Citations (1)

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Publication number Priority date Publication date Assignee Title
EP0544592A2 (fr) * 1991-11-28 1993-06-02 Sanofi Héparosanes-N,O-sulfates de haute masse moléculaire, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent

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US4636524A (en) 1984-12-06 1987-01-13 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US4713448A (en) 1985-03-12 1987-12-15 Biomatrix, Inc. Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues
JPH01265970A (ja) 1988-04-19 1989-10-24 Shiseido Co Ltd ヒアルロン酸を含有させたコラーゲン水溶液又は水分散液
US5550187A (en) 1988-11-21 1996-08-27 Collagen Corporation Method of preparing crosslinked biomaterial compositions for use in tissue augmentation
US5510418A (en) 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
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IT1271057B (it) 1994-11-04 1997-05-26 Inalco Spa Polisaccaridi aventi un elevato contenuto di acido iduronico
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IT1282994B1 (it) 1996-05-10 1998-04-03 Inalco Spa Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante
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WO2000027437A2 (fr) 1998-11-11 2000-05-18 The Board Of Regents Of The University Of Oklahoma Greffage de polymères par polysaccharide synthases
FR2780730B1 (fr) 1998-07-01 2000-10-13 Corneal Ind Compositions biphasiques injectables, notamment utiles en chirurgies reparatrice et esthetique
US20040197868A1 (en) 2001-05-08 2004-10-07 Deangelis Paul L. Heparin/heparosan synthase from P. multocida, soluble and single action catalysts thereof and methods of making and using same
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US6436424B1 (en) 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
DE60139993D1 (de) 2000-04-25 2009-11-05 Univ Oklahoma Chondroitin synthasegen und verfahren zur dessen herstellung und anwendung
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US6833488B2 (en) 2001-03-30 2004-12-21 Exotech Bio Solution Ltd. Biocompatible, biodegradable, water-absorbent material and methods for its preparation
US8580290B2 (en) 2001-05-08 2013-11-12 The Board Of Regents Of The University Of Oklahoma Heparosan-based biomaterials and coatings and methods of production and use thereof
EP1392843B1 (fr) 2001-05-08 2017-12-13 The Board of Regents of the University of Oklahoma Heparine/heparosan synthases et procedes de fabrication correspondant
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Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0544592A2 (fr) * 1991-11-28 1993-06-02 Sanofi Héparosanes-N,O-sulfates de haute masse moléculaire, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
A E SUSMEZ/RAGATZ ET AL.: "Chemoenzymatic synthesis with distinct Pasteurella heparosan synthases", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, no. 39, 28 September 2007 (2007-09-28), American Society for Biochemistry and Molecular Biology, pages 28321 - 28327, XP055116675, ISSN: 0021-9258 *
N J OTTO ET AL.: "Structure-function analysis of Pasteurella multocida heparosan synthase (incl supplemental data)", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 287, no. 10, 10 January 2012 (2012-01-10), American Society for Biochemistry and Molecular Biology, pages 7203 - 7212+7PP, XP002754818, ISSN: 0021-9258 *
See also references of WO2013149161A1 *

Also Published As

Publication number Publication date
US20180251803A1 (en) 2018-09-06
CA2869128A1 (fr) 2013-10-03
CA2869128C (fr) 2022-07-26
WO2013149161A1 (fr) 2013-10-03
US8980608B2 (en) 2015-03-17
TR201802761T4 (tr) 2018-03-21
US20130261079A1 (en) 2013-10-03
US20150150900A1 (en) 2015-06-04
AU2013237894B2 (en) 2018-06-21
US20170198325A1 (en) 2017-07-13
US9885072B2 (en) 2018-02-06
ES2661575T3 (es) 2018-04-02
BR112014024291A2 (fr) 2017-06-20
EP2831237B1 (fr) 2017-11-29
US20140107066A1 (en) 2014-04-17
PL2831237T3 (pl) 2018-06-29
BR112014024291B1 (pt) 2022-07-05
US10392642B2 (en) 2019-08-27
EP2831237A1 (fr) 2015-02-04
DK2831237T3 (en) 2018-03-05
AU2013237894A1 (en) 2014-10-30

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