EP2823799B1 - Device and method for inserting films in tablet presses - Google Patents
Device and method for inserting films in tablet presses Download PDFInfo
- Publication number
- EP2823799B1 EP2823799B1 EP13176062.1A EP13176062A EP2823799B1 EP 2823799 B1 EP2823799 B1 EP 2823799B1 EP 13176062 A EP13176062 A EP 13176062A EP 2823799 B1 EP2823799 B1 EP 2823799B1
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- EP
- European Patent Office
- Prior art keywords
- module
- films
- carriers
- takeover
- tablet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 238000000034 method Methods 0.000 title claims description 35
- 239000000969 carrier Substances 0.000 claims description 88
- 238000012546 transfer Methods 0.000 claims description 46
- 230000032258 transport Effects 0.000 claims description 14
- 238000003780 insertion Methods 0.000 claims description 4
- 230000037431 insertion Effects 0.000 claims description 4
- 125000006850 spacer group Chemical group 0.000 claims description 2
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- 239000010408 film Substances 0.000 description 169
- 239000000843 powder Substances 0.000 description 28
- 239000011888 foil Substances 0.000 description 16
- 238000003825 pressing Methods 0.000 description 12
- 239000010410 layer Substances 0.000 description 11
- 238000004519 manufacturing process Methods 0.000 description 10
- 238000003860 storage Methods 0.000 description 8
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- 238000000465 moulding Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000013543 active substance Substances 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 239000013039 cover film Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
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Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
- B30B11/08—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
- B30B15/30—Feeding material to presses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
Definitions
- the invention relates to a transfer and positioning device and to a method for placing a film in the die of a tablet press.
- rotary tablet presses are described for example for the pharmaceutical industry, with which normal single-layer tablets, multi-layer tablets and / or Mantelkerntabletten can be produced.
- the production of Mantelkerntabletten is very expensive, since in a tablet, a second tablet - a so-called core - is.
- the tablet presses which are suitable for the production of coated tablets, have in the jacket core design on the pitch circle of the die plate of a tablet press not only one but in particular two filling devices for powder. These two powder filling devices contain the powder with which the core of a mantle core tablet is encased.
- a core module located between the two powder filling the tablet press a core module, via which the cores to be coated are introduced individually into the die of a rotary tablet press.
- the cores to be coated are fed to the core module in the usual way as bulk material.
- the actual pressing process for the production of coated tablets proceeds in such a way that initially powder is introduced via the first powder filling device in the die of the tablet press and then the core to be coated is introduced by means of core module into the die.
- the second Pulver Stahls By means of the second Pulveryogll réelles the inserted core is covered with powder, the powder is finally compacted by the pressing process, thereby creating a solid shell, the so-called coat around the core.
- each mantle core tablet is monitored. If no core or only parts of a core have been inserted, the pressing force drops below the lower control limit, the tablet is recognized as defective and automatically sorted out via a pneumatic switch. In this way it can be ensured that each wrapper core tablet actually has a core.
- the EP 2 110 232 A2 is considered as the closest prior art to the independent claims and discloses a method and apparatus for inserting inserts in dies of a rotary tablet press, in which a core feeder with a core singler and a core dispenser forms a feeder chain.
- EP 0 349 777 A1 describes a jacket core press, in which a device for receiving and transferring cores is provided on the underside of raised and lowered core punches, which include gripping means for transporting the cores.
- a disadvantage of the devices and methods in the prior art is that only cores can be sheathed, which can be supplied as bulk material to the core module. Shaped bodies that stick to one another, are very light, limp and / or can not be supplied as individual shaped bodies to the core module in the sense of a bulk material due to their shape or nature, can not be used as a core for a sheath core tablet.
- the object of the present invention is therefore to provide a device and a method which do not have the disadvantages and deficiencies of the prior art and offer a solution to coat particularly flexible moldings that were previously inaccessible as a core for a Mantelkerntablette.
- FIG. 5 an exemplary embodiment of the device is shown.
- the FIG. 5 also shows how the modules 1, 2 and 3 interact.
- the device is in particular computer-controlled and comprises suitable drives in order to ensure the functionality of the modules, so that the device and the method of the present invention are in particular automatically controllable.
- Module 1 comprises in particular a storage magazine for films, wherein the films are individually packaged. It has proved to be advantageous if module 1 is suitable for providing the films to be coated in such a way that the films can be taken over individually.
- Module 1 comprises a storage magazine in which the films are not provided as bulk material, as in the prior art, but individually packaged. This can be done, for example, over a long carrier tape comprising molded troughs in which the films are located.
- the troughs of the carrier tape are covered in particular for storage and transport purposes with a protective film.
- the carrier tape can be rolled up, for example.
- Module 1 preferably comprises a receptacle for a plurality of rolls with carrier tapes. Further, the carrier tape can be manually or automatically transported with module 1, unrolled and the films are unpacked, so that the films are removed from the wells individually. The removal takes place in particular with module 2. It is advantageous that this way of providing films by means of module 1 automatically and optionally discontinuously or continuously, thereby enabling reproducible delivery of films.
- module 2 comprises the following units which are selected from the group transfer units, receiving elements, conveyor belts, deflecting wheels, guide rails, spacers, stoppers, control sensors, inlet wheels, discharge wheels and / or switches.
- deflecting wheels comprises in particular inlet wheels and / or outlet wheels.
- An exemplary embodiment of module 2 is in FIG. 2 shown. These FIG. 2 also shows the interaction of the transfer units, conveyor belts, control sensors, inlet wheels, sprockets and switches.
- the module 2 essentially comprises the transfer unit, which as a receiving element comprises a "pick and place" unit, which is in particular equipped with vacuum heads to suck the films.
- the acquisition unit of module 2 as a receiving element comprises a transfer head with up to 50 vacuum heads, preferably with up to 30 vacuum heads, more preferably with up to 20 vacuum heads, and most preferably with up to 10 vacuum heads. Of course, for example, 5 vacuum heads or 1 vacuum head can be used.
- module 2 comprises two flexible conveyor belts with deflection wheels.
- the conveyor belts are flexible and can accommodate, for example, about 300 carriers. With the carriers, the films are transported on the conveyor belt to module 3 (takeover and pressfit module).
- the guide rails of module 2 are designed so that the carriers can be kept in the track during their transport. Automatic stoppers prevent uncontrolled damming of the carriers.
- four optical control sensors are involved in the control of module 2.
- the module 2 comprises a capacity for 5000 carriers, preferably for 2500 carriers, more preferably for 1000 carriers, and most preferably for 300 carriers.
- module 2 For example, only 50 carriers can be used. It is also preferred that the carriers include locating holes for centering the foils. It was surprising that by the interaction of the different units of module 2, a transport can be realized that runs reproducibly. By the particular automatic procedure, a controlled method can be provided to make sensitive moldings accessible to automatic further processing.
- the module 2 is particularly suitable due to the modular design and the flexible and variable in length conveyor belt to customize the required throughput. Just the variability and flexibility of the present invention and especially when transporting ein theder, sensitive films to realize a high number of pieces was completely surprising.
- module 3 comprises vacuum heads, movable arms, at least two control cams, compressed air connections and / or vacuum connections, the vacuum heads being lowerable and immersed in dies of the tablet press.
- the vacuum heads of module 3 are designed as transfer / transfer heads, which take over as part of module 3 films of module 2 and represent a removal device.
- the vacuum heads furthermore constitute, as part of module 3, an insertion unit which inserts or transfers the films taken over from module 2 into the dies of the tablet press.
- the rotational speed of module 3 is variable and adjustable synchronously with the rotor speed of the tablet machine.
- Module 3 adopts the films of module 2. Module 3 is able to suck the films from the carriers through the vacuum heads.
- FIG. 3 an exemplary embodiment of the module 3 is shown.
- the FIG. 2 shows how the modules 2 and 3 interact.
- the invention can be used in a variety of ways and can be tailored to the most diverse requirements individually, for example with regard to throughput and speed.
- the films are inserted substantially centrally in the matrices. It is preferred if the films are an information carrier, a release layer and / or a drug carrier, wherein the films are light, pliable, flexible, flexible, rigid and / or rechargeable. It is also preferred that the films have all conceivable shapes and are, for example, round, angular, oval or asymmetrical. In particular, the films have a diameter of from 1 mm to 20 mm, preferably from 1 mm to 15 mm, more preferably from 1 mm to 10 mm and most preferably from 1 mm to 5 mm.
- the films may have a thickness of from 0.1 mm to 10 mm, preferably from 0.1 mm to 5 mm, more preferably from 0.1 mm to 1 mm and most preferably from 0.1 mm to 0.5 mm. It was completely surprising that the present invention opens up a wide range of possibilities for making a wide variety of shaped bodies accessible to tabletting which hitherto could not be processed in or into a tablet.
- the films comprise in particular plastics as material, but also natural substances, composites, metals or else mixtures or alloys are for example included as material of the present invention.
- the films can represent a one- or multi-component system.
- the films are for example homogeneous in their nature, may have a smooth or rough surface and / or consist of particulate material. It is also preferred if the films consist of a soluble material which dissolves in association with liquids, for example in the stomach or intestinal tract.
- the films may also contain a pharmaceutically active agent which is released, for example, during dissolution or disintegration of the film.
- Both in insoluble films and in the soluble films smallest solid particles can be embedded. These solid particles may have a size of 0.5-50 mm 3 . It is further preferred if the particles have a diameter which is less than 20 mm, preferably less than 10 mm, more preferably less than 5 mm and most preferably less than 1 mm.
- the particles may be, for example, electronic chips, which are in particular biodegradable.
- films in particular comprise chips which monitor, regulate and / or control physiological effects.
- the films can also be used as in vivo or in vitro markers for control and verification purposes.
- the films which can be processed with the present invention are very light in comparison to the cores used in the production of normal mantle core tablets, very small in size, unstable, elastically deformable and / or electrostatically chargeable. It is advantageous that also films can be processed, the at Increase increased humidity together. This means that it is possible to encase foils that are freely movable in the room with minimal air circulation in the room and / or that adhere to any objects that touch them with the least amount of electrostatic charge. It was completely surprising that with the present invention such diverse shaped bodies can be introduced into the matrix of a tablet press. It is precisely this multiplicity of differently configured films in size, shape, texture, weight and appearance that represents a significant advantage over the prior art.
- films in which a delivery excretes as bulk material can be processed, for example, with the present invention. It was completely surprising that it was possible to dispense with vibrators or centrifugal conveyors when feeding the films to the tablet press and when introducing them into a die.
- Module 1 brings the foils into the transfer position, where the foils of Module 2 are taken over.
- the films are delivered in a molded plastic carrier tape on a carrier tape spool, comparable to a film spool.
- This carrier tape has shaped, for example deep-drawn, hollows, in each of which a film is located.
- the carrier tape made of plastic, for example, provided with a self-adhesive masking tape, so that the slides can not fall out.
- One side of the carrier tape is perforated like a film strip for unwinding and positioning the rolled-up carrier tape.
- the module 1 comprises, for example, a device which can accommodate up to 1000 carrier tape reels, preferably up to 100 carrier tape reels and most preferably up to 10 carrier tape reels with carrier tapes.
- the carrier tape is threaded to provide the films, for example, in a so-called feeder, which automatically replaces the self-adhesive masking tape, wound and motor, for example, every 1.5 seconds brings a film in the takeover position.
- a so-called feeder which automatically replaces the self-adhesive masking tape, wound and motor, for example, every 1.5 seconds brings a film in the takeover position.
- ten feeders in particular discontinuously, for example clocked, ten films can be provided every 1 second for collection by module 2.
- the films are delivered by means of one or more film trays.
- the films are then punched out of the film tray, for example, either individually or in several pieces directly before being provided, brought into the transfer position after punching by means of module 1 and made available for collection by module 2.
- the process steps of providing the films by means of module 1 and / or taking over the films by means of module 2 are discontinuous.
- the films for example, after they have been provided by means of module 1, are taken over by module 2 clocked.
- a continuous provision of the films and a continuous acquisition of the films by module 2 is covered by the present invention.
- the module 2 comprises for taking over the films of module 1, a suitable receiving element. This receiving element is, for example, a "pick and place" unit, which takes over the films provided with module 1.
- the "Pick and Place” unit of module 2 comprises an extendable arm and a transfer head with, for example, 10 suction cups.
- the arm of the "pick and place” unit is brought into a position so that the transfer head of the "pick and place” unit with the 10 suction heads is located directly above the foils provided with module 1.
- the films are provided in particular by means of 10 feeders arranged in series, so that 10 films can be taken over at the same time. By vacuum, the films are sucked by the suction heads of the "Pick and Place” unit.
- the diameter of the suction heads at the contact surface to the film corresponds approximately to the diameter of the films.
- the transfer head of the "pick and place” unit of module 2 lifts the films out of the carrier tape and brings the films to, for example, ten waiting carriers, which are located on a conveyor belt 1.
- at least one conveyor belt with at least two webs is used and the receiving element of module 2 is alternately fed the carriers on web 1 and web 2 with films.
- the films are transferred from the suction heads of the "pick and place” unit (receiving element) of the module 2 to the carrier by the films are deposited in the receiving bores of the carrier.
- the films are centered on the carriers.
- the mounting holes of the carriers are slightly conical, so that a further centering of the films is ensured.
- 10 carriers are loaded simultaneously with films. After loading the carriers, which are located on track 1, the carriers loaded with films are preferably controlled by sensors. This monitors whether all carriers are actually loaded with a foil. As soon as the 10 carriers are loaded, a stopper opens the web 1 and the 10 carriers are moved in the direction of module 3 by the permanently running flexible conveyor belt 1.
- the carriers of both tracks are brought together on a web and in the absence of loading the carrier with a film, the carriers are pushed by a switch on a second conveyor belt, the empty carrier to reload the carrier with slides.
- the carriers are made of stainless steel, so that they are stable with the necessary weight on the conveyor belt.
- the inserts on the upper part of the carrier are made of white FDA-approved plastic.
- the slides in turn For example, they are colored dark, so that there is a clear contrast to the white inserts. This makes it easier for the sensors to reliably detect the inserted foils. If slides are missing in individual carriers, there is a message about this and you can check whether the fault is due to the feeders of module 1 or to individual suction heads of the "Pick and Place" unit of module 2.
- the conveyor belt 1 is arranged so that the carrier of the two webs 1 and 2 are dammed and mutually released on a web on the conveyor belt side opposite to the "pick and place” unit. As a result, the clocked transport of the carrier goes into a continuous transport.
- module 2 comprises an inlet wheel, which adjusts a distance between the carriers and continuously transfers the carrier with the films to module 3. It is advantageous that the module 3, in contrast to the feeders of module 1 and the "pick and place" unit of module 2 works continuously.
- Module 3 in particular represents a film press-in module which runs synchronously and continuously with the rotor of the tablet press.
- An advantage is that module 2 realizes a balance between the clocked operation of the film acquisition of module 1 and the continuous operation in the film transfer by module 3 to the tablet press.
- the films are taken clocked by the receiving element of the module 2 and inserted by module 3 in a continuous operation in the dies of the tablet press.
- the films are guided centrally from the takeover by the receiving element of module 2 until they are placed in the matrices of the tablet press by means of carriers or transported by centric positive engagement on the vacuum heads.
- a further conveyor belt 2 is present.
- the two conveyor belts for example, connected to each other via a switch.
- the switch to the conveyor belt 2 is another optical sensor which controls the presence of a film on the carrier. If there is no foil in the receiving bore of the carrier, the carrier is pushed by conveyor belt 1 on conveyor belt 2 and automatically transported back to the charging station via a second switch.
- the charging station is the station where the films are transferred to the carriers by means of a "pick and place" unit. Thus, only loaded carriers are continuously forwarded to module 3, the so-called takeover and press-in station.
- the module 2 comprises an inlet wheel and an outlet wheel. Through the recesses in the inlet wheel, the carriers are brought to the stitch spacing of the transfer / transfer heads of module 3. Between the inlet wheel and the outlet wheel, the transfer / transfer heads of module 3 take over the transport of the carriers. As with the "Pick and Place" unit of module 2, module 3 also includes suction cups. By means of a control cam drive the suction heads down and take the slides from the carriers by means of vacuum. It is preferred that the films are centered in the acquisition by module 3. It is further preferred that empty carriers are supplied to the module 2, after removal of the films by module 3 or by suction, by means of at least one outlet wheel and are provided for a new loading with films.
- sensors check the removal of the films from the carriers by module 3. It is also preferred that a film is sucked off, which was not removed by module 3 and is still in the carrier after passing through module 3. Also in module 3, the contact surface of the suction cups corresponds to the diameter of the films.
- the vacuum heads (suction heads) of module 3 After the vacuum heads (suction heads) of module 3 have removed the films from the carriers, the vacuum heads (suction heads) with the films are driven upwards again. The empty carriers are transferred to the discharge wheel and fed to the conveyor belt 1.
- an optical sensor that checks whether a film has remained in the carrier and possibly has not been taken over by the suction heads of module 3. If this is the case, the foil remaining in the carrier is automatically sucked off with a nozzle. This prevents a carrier with a film in the charging station and there could be equipped with an additional film.
- the vacuum heads of module 3 in the position opposite the takeover by module 2 on the pitch circle of the matrix of the tablet press move in synchronism with the die position.
- the movable arms move to the die plate of the tablet press (rotary press).
- the rotational speed of module 3 is controlled synchronously by the rotor speed of the tablet press.
- the heads are pressed down so that the vacuum heads dive with the films in the die holes and so the discs can be pressed in particular in the press material of a first layer of powder.
- the vacuum is switched off and a subsequent slight blast of compressed air ensures that the films do not stick to the suction head.
- the vacuum heads leave the die holes, are returned to the old pitch circle via the control cam, the vacuum lines are blown open with a powerful blast of compressed air, and then take over the next foils from the carriers. In this way, the films are individually placed in the dies of the tablet press.
- the tablet press comprises two powder filling devices and two pressing stations. It is an advantage if one pressing station is located to the left and right of module 3. With the pressing station 1, the powder (pressing material) of the first layer, which has been placed in the matrix, is pressed lightly in order to vent the material and to obtain a smooth surface. Subsequently, the film via the module 3 is automatically and continuously introduced into the die. It is preferred that the films are inserted centrally into the dies of the tablet press.
- the turntable of the module 3 operates synchronously with the operating speed of the rotor of the tablet press, so that the films are continuously inserted into the matrices.
- the films are deposited on the first compressed powder layer.
- the film With the second pressing station, the film is lightly pressed and pressed into the first powder layer.
- the first layer with the inserted foil is simultaneously pushed into the filling position for the second powder layer. This creates a filling space for the second powder layer (Top layer).
- the resulting cavity is then filled with the second filling shoe and, for example, the same pressing material as in the presentation of the first powder layer in the die.
- the press material is pressed by means of the upper and lower punches and with the help of the pre-press and the main press to a coated tablet.
- the coated tablet is ejected and passed with the tablet scraper over the chute from the tablet press.
- FIG. 1 shows a plan view of module 1 (11), in particular a feeder (15), in which, for example, 10 shaped carrier tapes for the films are arranged side by side so that at the same time 10 films of module 2 (12) can be adopted.
- the module 1 (11) comprises a storage space for receiving the carrier tapes. From this storage room, the carrier tapes can be brought with the films manually or automatically through an opening in the position where the films from module 2 (12). When unrolling the carrier tape, the cover film is pulled off in particular over the molded, for example deep-drawn, hollows in which the films to be coated are located. In this way, the films are accessible for acquisition by module 2 (12) and thus provided.
- module 1 (11) variable in the Height is and can be docked to the module 2 (12) and in this way a direct contact between the supply unit of module 1 (11) and the "pick and place” unit (16) of module 2 (12) can be produced.
- FIG. 2 shows a plan view of module 2 (12), which for example a "pick and place” unit (16), conveyor belt 1 (17) with two tracks (18a, 19), inlet wheel (22), outlet wheel (23), optical control sensors (20), conveyor belt 2 (21) and switches (24a, 24b).
- the module 2 (12) comprises a capacity for, for example, 300 carriers (28).
- the films of module 1 (11) are taken, placed on carriers (28) and transported on the carriers (28) by means of the conveyor belt 1 (17) to the module 3 (13).
- a takeover arm is extended for module takeover of module 2 (12) and preferably placed directly over the provided foils.
- the transfer arm preferably comprises, for example, 10 suction heads with which 10 films can be sucked in at the same time by means of a vacuum.
- the transfer arm is part of the "Pick and Place" unit (16).
- the transfer arm is extendable and rotatable by, for example, 360 °, preferably 180 ° horizontally.
- takeover arm can be extended vertically and variably adjusted.
- the carriers (28) were sensory checked before deployment (20), whether the carriers (28) are not already loaded with a film. Only empty carriers (28) are provided for loading with foils. After loading, we open a stopper and the loaded with slides Carrier (28) are on the permanent running Transport belt 1 (17) moves. In FIG. 2 the direction of travel of the conveyor belt 1 (17) and thus the carrier (28) is provided in particular in the counterclockwise direction.
- the module 2 (12) has, in particular, guide rails to ensure that the carriers (28) can not leave the conveyor belt 1 or 2 (17, 21) during transport.
- guide rails on the flexible conveyor belt (17, 21) it is also possible, for example, that the carriers (28) can follow directional changes of the conveyor belt 1 or 2 (17, 21) during transport.
- the conveyor belt 1 (17) is arranged so that on the way to the module 3 (13) two horizontal changes of direction are performed by 90 °.
- FIG. 2 shows, in the position of the switch 24b the transition from conveyor belt 1 (17) to conveyor belt 2 (21). This represents the position where unloaded carriers (28) detected by sensory control (20) are sorted out and fed via conveyor belt 2 (21) to a loading position of the pick and place unit (16).
- the two webs 18a, 19 of conveyor belt 1 (17) are brought together prior to the carrier transfer to module 3 (13) to web 18b.
- the carriers (28) are dammed before transfer to the module 3 (13) and then via the inlet wheel (22) a defined distance between the loaded carriers (28) is set. It is thereby achieved that the carriers (28) have exactly the distance which is necessary for the transfer / transfer heads (25) of module 3 (13) to be able to take over the films from the carriers (28).
- FIG. 3 shows a view of module 3 (13).
- Module 3 (13) is the so-called take-over and press-in unit. The slides are taken from the carriers (28).
- acquisition / transfer heads (25) include vacuum suction heads, which suck the films from the carriers (28).
- the takeover and press-in unit (module 3) (13) is in particular rotatable about an axis parallel to the axis of the die table (26) of the tablet press (14).
- Module 3 (13) comprises in particular a rotor which is provided with radial arms and in the head parts radially movable transfer / transfer heads (25) are mounted, which can be brought to the transfer of the films with the matrices in coverage.
- the module 3 (13) is rotatable and capable of performing the same rotational speed as the tablet press (14).
- the films are in the die openings the tablet press (14) inserted.
- the transfer / transfer heads (25) of module 3 (13) for example vacuum heads, can be positioned directly above or in the die openings of a tablet press (14) in order to load the films.
- the transfer / transfer heads (25) are vertically adjustable, in particular by means of control cams.
- the transfer / transfer heads (25) can be retracted horizontally to bring them into coincidence with the die opening. In this way, a precise and centric positioning of the films in the mold of a tablet press (14) is possible.
- FIG. 4 shows the top view of a tablet press (14) with upper punch heads (27), which dive in particular in the die openings in order to compress the powder and thus to coat the inserted film.
- the tablet press (14) used to make coated tablets comprises a rotary driven die table (26) with dies arranged on a pitch circle.
- the tablet press (14), which is suitable for the production of coated tablets with inserted films comprises not only one but in particular two filling devices for powders in the jacket core design on the pitch circle of the die table (26). These two powder filling devices contain the powder with which the film is encased in the coated tablet. With a powder filling device powder is placed in the die, then inserted the film and finally covered with the second powder filling the film.
- the powder filling devices contain different types of powder, if necessary. After filling the matrix with powder, the film by means of module 3 (13) and again powder is followed by the actual pressing process, with which the tablet is produced comprising a sheathed film.
- FIG. 5 shows, for example, how the modules 1 (11) to 3 (13) and tablet press (14) can be interconnected or arranged to remove the films from the storage container or storage magazine and finally insert into the tablet press (14).
- the individual modules are height adjustable or matched in height to each other.
- the device in FIG. 5 can be individually in its capacity by, for example, additional length of the conveyor belts (17, 21), higher number of carriers (28), multiple carrier tapes in the feeder (15) of the module 1 (11), the number of picking heads in the "Pick and Place” Unit (16) and, for example, the number of lanes individually to the required Throughput when inserting the films in the tablet press (14) can be adjusted.
- FIG. 6 shows, for example, a carrier (28) with a receiving bore (29) for the film.
- the carriers (28) are preferably made of stainless steel. This has the advantage that the carriers (28) have a weight that allows stable transport on the conveyor belt (17, 21). It is further preferred that the carriers (28) also comprise plastic.
- the plastic part of the carrier (28) in particular represents the contact surface between the film and the carrier (28).
- the carrier (28) has a receiving bore (29) for the film at the contact surface, whereby the film is centered and penetrated through the depression (29 ) can not fall from the carrier (28) during transport, but is guided centered.
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Description
Die Erfindung betrifft eine Übernahme- und Positioniereinrichtung sowie ein Verfahren, um eine Folie in der Matrize einer Tablettenpresse platzieren zu können.The invention relates to a transfer and positioning device and to a method for placing a film in the die of a tablet press.
Im Stand der Technik sind Rundlauftablettenpressen beispielsweise für die pharmazeutische Industrie beschrieben, mit welchen normale Einschichttabletten, Mehrschichttabletten und/oder Mantelkerntabletten hergestellt werden können. Insbesondere die Herstellung von Mantelkerntabletten ist sehr aufwendig, da sich in einer Tablette eine zweite Tablette - ein sogenannter Kern - befindet.In the prior art, rotary tablet presses are described for example for the pharmaceutical industry, with which normal single-layer tablets, multi-layer tablets and / or Mantelkerntabletten can be produced. In particular, the production of Mantelkerntabletten is very expensive, since in a tablet, a second tablet - a so-called core - is.
Die Tablettenpressen, die sich zur Herstellung von Manteltabletten eignen, weisen in der Mantelkernausführung auf dem Teilkreis der Matrizenplatte einer Tablettenpresse nicht nur einen sondern insbesondere zwei Füllgeräte für Pulver auf. Diese beiden Pulverfüllgeräte beinhalten jenes Pulver, mit welchem der Kern einer Mantelkerntablette ummantelt wird.The tablet presses, which are suitable for the production of coated tablets, have in the jacket core design on the pitch circle of the die plate of a tablet press not only one but in particular two filling devices for powder. These two powder filling devices contain the powder with which the core of a mantle core tablet is encased.
Um eine derartige Ummantelung zu erreichen, befindet sich zwischen den beiden Pulverfüllgeräten der Tablettenpresse ein Kernmodul, über das die zu ummantelnden Kerne einzeln in die Matrize einer Rundlauftablettenpresse eingebracht werden. Die zu ummantelnden Kerne werden dem Kernmodul üblicher Weise als Schüttgut zugeführt.In order to achieve such a jacket, located between the two powder filling the tablet press a core module, via which the cores to be coated are introduced individually into the die of a rotary tablet press. The cores to be coated are fed to the core module in the usual way as bulk material.
Der eigentliche Pressvorgang zur Herstellung von Manteltabletten läuft in der Weise ab, dass zunächst Pulver über das erste Pulverfüllgerät in der Matrize der Tablettenpresse vorgelegt wird und dann der zu ummantelnde Kern mittels Kernmodul in die Matrize eingebracht wird. Mittels des zweiten Pulverfüllgeräts wird der eingelegte Kern mit Pulver bedeckt, das Pulver wird schließlich durch den Pressvorgang verdichtet und dadurch eine feste Hülle, der sogenannte Mantel, um den Kern erzeugt.The actual pressing process for the production of coated tablets proceeds in such a way that initially powder is introduced via the first powder filling device in the die of the tablet press and then the core to be coated is introduced by means of core module into the die. By means of the second Pulverfüllgeräts the inserted core is covered with powder, the powder is finally compacted by the pressing process, thereby creating a solid shell, the so-called coat around the core.
Während der Herstellung der Mantelkerntablette wird die Presskraft jeder einzelnen Mantelkerntablette überwacht. Sollte kein Kern oder nur Teile eines Kernes eingelegt worden sein, sinkt die Presskraft unter die untere Kontrollgrenze, die Tablette wird als fehlerhaft erkannt und automatisch über eine pneumatische Weiche aussortiert. Auf diese Weise kann sichergestellt werden, dass jede Mantelkerntablette auch tatsächlich einen Kern aufweist. Die
In der
Nachteilig an den Vorrichtungen und Verfahren im Stand der Technik ist, dass nur Kerne ummantelt werden können, die als Schüttgut dem Kernmodul zugeführt werden können. Formkörper, die aneinander kleben, sehr leicht, biegeschlaff sind und/oder sich aufgrund ihrer Form oder Beschaffenheit nicht als einzelne Formkörper dem Kernmodul im Sinne eines Schüttguts zuführen lassen, können nicht als Kern für eine Mantelkerntablette verwendet werden.A disadvantage of the devices and methods in the prior art is that only cores can be sheathed, which can be supplied as bulk material to the core module. Shaped bodies that stick to one another, are very light, limp and / or can not be supplied as individual shaped bodies to the core module in the sense of a bulk material due to their shape or nature, can not be used as a core for a sheath core tablet.
Aufgabe der vorliegenden Erfindung ist es daher, eine Vorrichtung und ein Verfahren bereitzustellen, welche nicht die Nachteile und Mängel des Standes der Technik aufweisen und eine Lösung anzubieten, um insbesondere flexible Formkörper zu ummanteln, die bisher als Kern für eine Mantelkerntablette nicht zugänglich waren.The object of the present invention is therefore to provide a device and a method which do not have the disadvantages and deficiencies of the prior art and offer a solution to coat particularly flexible moldings that were previously inaccessible as a core for a Mantelkerntablette.
Gelöst wird die Aufgabe durch ein Verfahren mit den Merkmalen des Anspruchs 1 und einer Vorrichtung mit den Merkmalen des Anspruchs 2. Vorteilhafte Ausführungsformen ergeben sich aus den Unteransprüchen.The object is achieved by a method having the features of claim 1 and a device having the features of claim 2. Advantageous embodiments emerge from the subclaims.
Die Erfindung betrifft in einer ersten bevorzugten Ausführungsform eine Vorrichtung zur Übergabe, zum Einlegen und zum Positionieren von Folien, die als Kern für eine Mantelkerntablette verwendet werden, in Matrizen von Tablettenpressen, wobei die Vorrichtung mindestens drei Module umfasst,
- a. Modul 1, umfassend mindestens eine Vorratseinheit, die die Folien beinhaltet und/oder mindestens eine Bereitstelleinheit, die die Folien zur Übernahme durch ein zweites Modul bereitstellt,
- b. Modul 2, umfassend mindestens eine Übernahmeeinheit, mindestens ein Transportband und mindestens ein Einlaufrad, wobei das Modul 2
- i. die Folien von Modul 1 mittels Aufnahmeelement übernimmt,
- ii. die Folien auf Carriern platziert,
- iii. die Carrier transportiert,
- iv. mittels Einlaufrad einen Abstand zwischen den Carriern einstellt,
- c. Modul 3, umfassend mindestens einen Vakuumkopf, welcher eine Entnahmevorrichtung umfasst, die die Folien von den Carriern des Moduls 2 entnimmt und in die Matrizen der Tablettenpresse einlegt.
- a. Module 1 comprising at least one storage unit containing the films and / or at least one provisioning unit providing the films for adoption by a second module,
- b. Module 2, comprising at least one transfer unit, at least one conveyor belt and at least one inlet wheel, wherein the module 2
- i. takes over the films of module 1 by means of a receiving element,
- ii. the slides placed on carriers,
- iii. the carriers are transported,
- iv. set a distance between the carriers by means of the infeed wheel,
- c. Module 3, comprising at least one vacuum head, which comprises a removal device, which removes the films from the carriers of the module 2 and inserts into the matrices of the tablet press.
In
Bevorzugt ist, dass Modul 2 folgende Einheiten umfasst, welche ausgewählt sind aus der Gruppe Übernahmeeinheiten, Aufnahmeelemente, Transportbänder, Umlenkräder, Führungsschienen, Abstandhalter, Stopper, Kontrollsensoren, Einlaufräder, Auslaufräder und/oder Weichen. Die Bezeichnung Umlenkräder umfasst insbesondere Einlaufräder und/oder Auslaufräder. Eine beispielhafte Ausgestaltung von Modul 2 ist in
Vorteilhaft ist weiter, wenn Modul 2 zwei flexible Transportbänder mit Umlenkrädern umfasst. Die Transportbänder sind flexibel und können beispielweise etwa 300 Carrier aufnehmen. Mit den Carriern werden die Folien auf dem Transportband zum Modul 3 (Übernahme- und Einpressmodul) transportiert. Die Führungsschienen von Modul 2 sind so ausgelegt, dass die Carrier bei ihrem Transport in der Spur gehalten werden können. Automatische Stopper verhindern ein unkontrolliertes Aufstauen der Carrier. An der Steuerung von Modul 2 sind beispielsweise vier optische Kontrollsensoren beteiligt. Mittels beispielsweise zweier Weichen werden insbesondere die zwei Transportbänder miteinander verbunden und die Richtung der sich auf dem Transportband befindlichen Carrier gesteuert. Vorzugsweise umfasst das Modul 2 eine Kapazität für 5000 Carrier, bevorzugt für 2500 Carrier, mehr bevorzugt für 1000 Carrier und am meisten bevorzugt für 300 Carrier. Selbstverständlich können beispielsweise auch nur 50 Carrier verwendet werden. Es ist auch bevorzugt, dass die Carrier Aufnahmebohrungen zum Zentrieren der Folien umfassen. Es war überraschend, dass durch das Zusammenwirken der verschiedenen Einheiten von Modul 2 ein Transport realisiert werden kann, der reproduzierbar abläuft. Durch den insbesondere automatischen Ablauf kann ein kontrolliertes Verfahren zur Verfügung gestellt werden, um empfindliche Formkörpern einer automatischen Weiterverarbeitung zugänglich zu machen. Das Modul 2 eignet sich insbesondere durch die modulare Bauweise sowie das flexible und in seiner Länge variable Transportband dazu, den benötigten Durchsatz individuell anzupassen. Gerade die Variabilität und Flexibilität der vorliegenden Erfindung und insbesondere beim Transport einzeln einzulegender, empfindlicher Folien eine hohe Stückzahl zu realisieren war vollkommen überraschend.It is also advantageous if module 2 comprises two flexible conveyor belts with deflection wheels. The conveyor belts are flexible and can accommodate, for example, about 300 carriers. With the carriers, the films are transported on the conveyor belt to module 3 (takeover and pressfit module). The guide rails of module 2 are designed so that the carriers can be kept in the track during their transport. Automatic stoppers prevent uncontrolled damming of the carriers. For example, four optical control sensors are involved in the control of module 2. By means of, for example, two switches, in particular the two conveyor belts are connected to one another and the direction of the carriers located on the conveyor belt is controlled. Preferably, the module 2 comprises a capacity for 5000 carriers, preferably for 2500 carriers, more preferably for 1000 carriers, and most preferably for 300 carriers. Of course, for example, only 50 carriers can be used. It is also preferred that the carriers include locating holes for centering the foils. It was surprising that by the interaction of the different units of module 2, a transport can be realized that runs reproducibly. By the particular automatic procedure, a controlled method can be provided to make sensitive moldings accessible to automatic further processing. The module 2 is particularly suitable due to the modular design and the flexible and variable in length conveyor belt to customize the required throughput. Just the variability and flexibility of the present invention and especially when transporting einzulegender, sensitive films to realize a high number of pieces was completely surprising.
Weiter bevorzugt ist, dass Modul 3 Vakuumköpfe, bewegliche Arme, mindestens zwei Steuerkurven, Druckluftanschlüsse und/oder Vakuumanschlüsse umfasst, wobei die Vakuumköpfe absenkbar sind und in Matrizen der Tablettenpresse eintauchen. Vorzugsweise sind die Vakuumköpfe von Modul 3 als Übernahme-/Übergabeköpfe ausgelegt, welche als Bestandteil von Modul 3 Folien von Modul 2 übernehmen und eine Entnahmevorrichtung darstellen. Die Vakuumköpfe stellen des Weiteren als Bestandteil von Modul 3 eine Einlegeeinheit dar, welche die von Modul 2 übernommenen Folien in die Matrizen der Tablettenpresse einlegt bzw. übergibt. Bevorzugt ist außerdem, dass die Drehgeschwindigkeit von Modul 3 variabel und synchron mit der Rotorgeschwindigkeit der Tablettenmaschine einstellbar ist. Modul 3 übernimmt die Folien von Modul 2. Modul 3 ist durch die Vakuumköpfe in der Lage, die Folien von den Carriern anzusaugen. Aufgrund der identischen Drehgeschwindigkeit von Modul 3 und dem Rotor der Tablettenmaschine kann eine kontrollierbare Übergabe der Folien in die Matrizenöffnungen der Tablettenmaschine erfolgen. In
Die Erfindung betrifft in einer weiteren bevorzugten Ausführungsform insbesondere ein Verfahren zur Übergabe, zum Einlegen und zum Positionieren von Folien, die als Kern für eine Mantelkerntablette verwendet werden, in Matrizen von Tablettenpressen, wobei das Verfahren die folgenden Verfahrensschritte umfasst,
- a. Bereitstellen der Folien mittels Modul 1, welches die Folien in die Übernahmeposition bringt,
- b. Übernahme der Folien durch Modul 2, wobei das Modul 2 die Folien mittels eines Aufnahmeelementes aufnimmt,
- c. Platzieren der Folien auf Carriern durch Modul 2, wobei die Folien auf den Carriern zentriert werden,
- d. Transport der Carrier zum Modul 3, wobei die Beladung der Carrier sensorisch überprüft wird,
- e. Übernahme der Folien durch Modul 3 mittels Vakuumköpfen,
- f. Positionieren der Folien in den Matrizen der Tablettenpresse, wobei die Folien eingelegt werden und
- a. Providing the films by means of module 1, which brings the films in the transfer position,
- b. Takeover of the films by module 2, wherein the module 2 receives the films by means of a receiving element,
- c. Placing the slides on carriers through module 2, with the slides centered on the carriers,
- d. Transport of the carrier to module 3, wherein the loading of the carrier is sensory checked,
- e. Takeover of the films by module 3 by means of vacuum heads,
- f. Positioning the films in the dies of the tablet press, the films are inserted and
Vorzugsweise werden die Folien im Wesentlichen zentrisch in die Matrizen eingelegt. Es ist bevorzugt, wenn die Folien ein Informationsträger, eine Trennschicht und/oder ein Wirkstoffträger sind, wobei die Folien leicht, biegeschlaff, nachgiebig, flexibel, starr und/oder aufladbar sind. Außerdem bevorzugt ist, dass die Folien alle denkbaren Formen aufweisen und beispielsweise rund, eckig, oval oder asymmetrisch sind. Die Folien weisen insbesondere einen Durchmesser auf von 1 mm bis 20 mm, bevorzugt von 1 mm bis 15 mm, mehr bevorzugt von 1 mm bis 10 mm und am meisten bevorzugt von 1 mm bis 5 mm. Die Folien können eine Dicke haben von 0,1 mm bis 10 mm, bevorzugt 0,1 mm bis 5 mm, mehr bevorzugt 0,1 mm bis 1 mm und am meisten bevorzugt von 0,1 mm bis 0,5 mm. Es war vollkommen überraschend, dass mit der vorliegenden Erfindung vielfältige Möglichkeiten eröffnet werden, unterschiedlichste Formkörper einer Tablettierung zugänglich zu machen, die bisher nicht in oder zu einer Tablette verarbeitet werden konnten.Preferably, the films are inserted substantially centrally in the matrices. It is preferred if the films are an information carrier, a release layer and / or a drug carrier, wherein the films are light, pliable, flexible, flexible, rigid and / or rechargeable. It is also preferred that the films have all conceivable shapes and are, for example, round, angular, oval or asymmetrical. In particular, the films have a diameter of from 1 mm to 20 mm, preferably from 1 mm to 15 mm, more preferably from 1 mm to 10 mm and most preferably from 1 mm to 5 mm. The films may have a thickness of from 0.1 mm to 10 mm, preferably from 0.1 mm to 5 mm, more preferably from 0.1 mm to 1 mm and most preferably from 0.1 mm to 0.5 mm. It was completely surprising that the present invention opens up a wide range of possibilities for making a wide variety of shaped bodies accessible to tabletting which hitherto could not be processed in or into a tablet.
Die Folien umfassen als Material insbesondere Kunststoffe, aber auch Naturstoffe, Verbundstoffe, Metalle oder auch Mischungen oder Legierungen werden beispielsweise als Material von der vorliegenden Erfindung umfasst. Die Folien können ein Ein- oder Mehrkomponentensystem darstellen. Die Folien sind beispielweise homogen in ihrer Beschaffenheit, können eine glatte oder raue Oberfläche aufweisen und/oder aus partikulärem Material bestehen. Bevorzugt ist auch, wenn die Folien aus einem löslichen Material bestehen, welches sich in Verbindung mit Flüssigkeiten zum Beispiel im Magen oder Darmtrakt auflöst. Die Folien können auch einen pharmazeutischen Wirkstoff enthalten, der beispielsweise während der Auflösung oder dem Zerfall der Folie freigesetzt wird.The films comprise in particular plastics as material, but also natural substances, composites, metals or else mixtures or alloys are for example included as material of the present invention. The films can represent a one- or multi-component system. The films are for example homogeneous in their nature, may have a smooth or rough surface and / or consist of particulate material. It is also preferred if the films consist of a soluble material which dissolves in association with liquids, for example in the stomach or intestinal tract. The films may also contain a pharmaceutically active agent which is released, for example, during dissolution or disintegration of the film.
Sowohl in unlöslichen Folien als auch in den löslichen Folien können kleinste feste Partikel eingebettet sein. Diese festen Partikel können eine Größe von 0,5 - 50 mm3 haben. Weiter bevorzugt ist, wenn die Partikel einen Durchmesser aufweisen, der kleiner 20 mm, bevorzugt kleiner 10 mm, mehr bevorzugt kleiner 5 mm und am meisten bevorzugt kleiner 1 mm ist. Die Partikel können beispielsweise elektronische Chips sein, die insbesondere biologisch abbaubar sind. Folien im Sinne der vorliegenden Erfindung umfassen insbesondere Chips, welche physiologische Effekte überwachen, regeln und/oder steuern. Die Folien können auch als in vivo oder in vitro Marker für Kontroll- und Verifizierungszwecke eingesetzt werden.Both in insoluble films and in the soluble films smallest solid particles can be embedded. These solid particles may have a size of 0.5-50 mm 3 . It is further preferred if the particles have a diameter which is less than 20 mm, preferably less than 10 mm, more preferably less than 5 mm and most preferably less than 1 mm. The particles may be, for example, electronic chips, which are in particular biodegradable. In the context of the present invention, films in particular comprise chips which monitor, regulate and / or control physiological effects. The films can also be used as in vivo or in vitro markers for control and verification purposes.
Es war überraschend, dass für die Herstellung von Manteltabletten, welche eine Folie umfassen, ein automatisiertes Verfahren möglich ist. Überraschender Weise konnten mit der vorliegenden Erfindung die Probleme des Standes der Technik überwunden werden. Bisher war die Herstellung von Manteltabletten mit Folien nur im Handbetrieb möglich. Mit der vorliegenden Erfindung werden Folien für die maschinelle Verarbeitung in Manteltabletten zugänglich gemacht. Es war vollkommen überraschend, dass mit handelsüblichen Rundlauftablettenpressen Manteltabletten herstellbar sind, die als Kern keine Tablette enthalten, sondern insbesondere eine Folie im Sinne der vorliegenden Erfindung. Es hat sich als vorteilhaft erwiesen, dass Stückzahlen realisiert werden können, die eine wirtschaftlich rentable Herstellung von Manteltabletten mit insbesondere Folien oder elektronischen Chips ermöglichen. Bisher war es nicht möglich Folien oder elektronische Chips automatisch gesteuert und überwacht in eine Tablette in einem kontinuierlichen Verfahren einzubringen.It was surprising that an automated process is possible for the production of coated tablets comprising a film. Surprisingly, the problems of the prior art could be overcome with the present invention. So far, the production of coated tablets with films was only possible in manual mode. With the present invention, films for machine processing in coated tablets are made available. It was completely surprising that coated tablet tablets can be produced with commercially available rotary tablet presses which do not contain a tablet as the core, but in particular a film in the sense of the present invention. It has proved to be advantageous that quantities can be realized which enable economically viable production of coated tablets, in particular films or electronic chips. So far, it has not been possible to automatically insert films or electronic chips controlled and monitored into a tablet in a continuous process.
Die mit der vorliegenden Erfindung verarbeitbaren Folien sind im Vergleich zu den Kernen bei der Herstellung normaler Mantelkerntabletten insbesondere sehr leicht, sehr klein in den Abmessungen, instabil, elastisch verformbar und/oder elektrostatisch aufladbar. Vorteilhaft ist, dass auch Folien verarbeitet werden können, die bei erhöhter Luftfeuchtigkeit aneinander kleben. D.h. es können Folien ummantelt werden, die bei geringsten Luftzirkulationen im Raum frei beweglich sind und/oder die bei der geringsten elektrostatischen Aufladung an allen Gegenständen, die sie berühren, kleben bleiben. Es war völlig überraschend, dass mit der vorliegenden Erfindung derartig vielfältige Formkörper in die Matrize einer Tablettenpresse eingebracht werden können. Gerade diese Vielzahl an unterschiedlich ausgestalteten Folien in Größe, Form, Beschaffenheit, Gewicht und Aussehen stellt einen wesentlichen Vorteil gegenüber dem Stand der Technik dar. Mit den Vorrichtungen und Verfahren des Standes der Technik waren diese verschiedenartigen Folien einem Einlegen in eine Tablettenpresse bisher nicht zugänglich. Insbesondere Folien, bei denen eine Anlieferung als Schüttgut ausscheidet können beispielsweise mit der vorliegenden Erfindung verarbeitet werden. Völlig überraschend war, dass bei der Zuführung der Folien zu der Tablettenpresse und beim Einbringen in eine Matrize auf Vibratoren oder Zentrifugalförderer verzichtet werden konnte.In particular, the films which can be processed with the present invention are very light in comparison to the cores used in the production of normal mantle core tablets, very small in size, unstable, elastically deformable and / or electrostatically chargeable. It is advantageous that also films can be processed, the at Increase increased humidity together. This means that it is possible to encase foils that are freely movable in the room with minimal air circulation in the room and / or that adhere to any objects that touch them with the least amount of electrostatic charge. It was completely surprising that with the present invention such diverse shaped bodies can be introduced into the matrix of a tablet press. It is precisely this multiplicity of differently configured films in size, shape, texture, weight and appearance that represents a significant advantage over the prior art. With the devices and methods of the prior art, these various films have hitherto not been accessible to insertion in a tablet press. In particular, films in which a delivery excretes as bulk material can be processed, for example, with the present invention. It was completely surprising that it was possible to dispense with vibrators or centrifugal conveyors when feeding the films to the tablet press and when introducing them into a die.
Es hat sich als vorteilhaft erwiesen, dass beim Verfahren zur Übergabe, zum Einlegen und zum Positionieren von Folien in Matrizen von Tablettenpressen die Folien zunächst mittels Modul 1 bereitgestellt werden. Dazu bringt das Modul 1 die Folien in die Übernahmeposition, wo die Folien von Modul 2 übernommen werden.It has proven to be advantageous that in the method for transferring, inserting and positioning films in dies of tablet presses, the films are first provided by means of module 1. Module 1 brings the foils into the transfer position, where the foils of Module 2 are taken over.
Für das Bereitstellen der Folien hat es sich als vorteilhaft erwiesen, wenn die Folien in einem geformten Trägerband aus Kunststoff auf einer Trägerbandspule, vergleichbar mit einer Filmspule, angeliefert werden. Dieses Trägerband hat geformte, beispielsweise tiefgezogene, Mulden, in denen sich jeweils eine Folie befindet. Das Trägerband aus Kunststoff ist beispielsweise mit einem selbstklebenden Abdeckband versehen, so dass die Folien nicht herausfallen können. Die eine Seite des Trägerbandes ist für das Abspulen und Positionieren des aufgerollten Trägerbandes wie ein Filmstreifen perforiert. Das Modul 1 umfasst beispielsweise eine Vorrichtung, welche bis zu 1000 Trägerbandspulen, bevorzugt bis zu 100 Trägerbandspulen und am meisten bevorzugt bis zu 10 Trägerbandspulen mit Trägerbändern aufnehmen kann.For the provision of the films, it has proven to be advantageous if the films are delivered in a molded plastic carrier tape on a carrier tape spool, comparable to a film spool. This carrier tape has shaped, for example deep-drawn, hollows, in each of which a film is located. The carrier tape made of plastic, for example, provided with a self-adhesive masking tape, so that the slides can not fall out. One side of the carrier tape is perforated like a film strip for unwinding and positioning the rolled-up carrier tape. The module 1 comprises, for example, a device which can accommodate up to 1000 carrier tape reels, preferably up to 100 carrier tape reels and most preferably up to 10 carrier tape reels with carrier tapes.
Das Trägerband wir zum Bereitstellen der Folien beispielsweise in einen sogenannte Feeder eingefädelt, welcher automatisch das selbstklebende Abdeckband ablöst, aufwickelt und motorisch beispielweise alle 1,5 Sekunden eine Folien in die Übernahmeposition bringt. Um die Fördermenge pro Zeiteinheit zu erhöhen, kann man mehrere Feeder nebeneinander in einer Reihe anordnen. Bei zum Beispiel zehn Feedern können insbesondere diskontinuierlich, beispielsweise getaktet, alle 1 Sekunde zehn Folien zur Abholung durch Modul 2 bereitgestellt werden.The carrier tape is threaded to provide the films, for example, in a so-called feeder, which automatically replaces the self-adhesive masking tape, wound and motor, for example, every 1.5 seconds brings a film in the takeover position. To increase the flow rate per unit of time, you can arrange several feeders side by side in a row. In the case of, for example, ten feeders, in particular discontinuously, for example clocked, ten films can be provided every 1 second for collection by module 2.
Es ist weiter bevorzugt, dass anstelle des Trägerbandes die Folien mittels eines oder mehrerer Folien-Trays angeliefert werden. Die Folien werden dann beispielsweise entweder einzeln oder zu mehreren Stück direkt vor dem Bereitstellen aus dem Folien-Tray gestanzt, nach dem Ausstanzen mittels Modul 1 in die Übernahmeposition gebracht und zur Abholung durch Modul 2 bereitgestellt.It is further preferred that, instead of the carrier tape, the films are delivered by means of one or more film trays. The films are then punched out of the film tray, for example, either individually or in several pieces directly before being provided, brought into the transfer position after punching by means of module 1 and made available for collection by module 2.
Bevorzugt ist, wenn die Verfahrensschritte Bereitstellen der Folien mittels Modul 1 und/oder Übernahme der Folien durch Modul 2 diskontinuierlich sind. So hat es sich als vorteilhaft erwiesen, wenn die Folien beispielsweise nachdem sie mittels Modul 1 bereitgestellt wurden, von Modul 2 getaktet übernommen werden. Aber beispielsweise auch ein kontinuierliches Bereitstellen der Folien und eine kontinuierliche Übernahme der Folien durch Modul 2 wird von der vorliegenden Erfindung erfasst. Das Modul 2 umfasst zur Übernahme der Folien von Modul 1 ein geeignetes Aufnahmeelement. Bei diesem Aufnahmeelement handelt es sich beispielsweise um eine "Pick and Place"-Einheit, welche die mit Modul 1 bereitgestellten Folien übernimmt.It is preferred if the process steps of providing the films by means of module 1 and / or taking over the films by means of module 2 are discontinuous. Thus, it has proved to be advantageous if the films, for example, after they have been provided by means of module 1, are taken over by module 2 clocked. But also, for example, a continuous provision of the films and a continuous acquisition of the films by module 2 is covered by the present invention. The module 2 comprises for taking over the films of module 1, a suitable receiving element. This receiving element is, for example, a "pick and place" unit, which takes over the films provided with module 1.
Es ist von Vorteil, wenn die "Pick and Place"-Einheit von Modul 2 einen ausfahrbaren Arm und einen Übernahmekopf mit zum Beispiel 10 Saugköpfen umfasst. Zur Übernahme der Folien wird der Arm der "Pick and Place"-Einheit in eine Position gebracht, sodass der Übernahmekopf der "Pick and Place"-Einheit mit den 10 Saugköpfen sich direkt über den mit Modul 1 bereitgestellten Folien befindet. Die Folien werden insbesondere mittels 10 in Reihe angeordneten Feedern bereitgestellt, so dass gleichzeitig 10 Folien übernommen werden können. Mittels Vakuum werden die Folien von den Saugköpfen der "Pick and Place"-Einheit angesaugt. Der Durchmesser der Saugköpfe an der Kontaktfläche zur Folie entspricht in etwa dem Durchmesser der Folien. Durch das Vakuum liegen die Folien ganzflächig an der Stirnseite des Saufkopfes und werden nicht deformiert. Die Kontaktfläche kann eine flache Eindrehung aufweisen, um die Folien zusätzlich zu zentrieren. Der Übernahmekopf der "Pick and Place"-Einheit von Modul 2 hebt die Folien aus dem Trägerband heraus und bringt die Folien zu beispielsweise zehn bereitstehenden Carriern, welche sich auf einem Transportband 1 befinden. Gemäss der Erfindung wird mindestens ein Transportband mit mindestens zwei Bahnen verwendet und wird das Aufnahmeelement von Modul 2 abwechselnd die Carrier auf Bahn 1 und Bahn 2 mit Folien beschickt. Die Folien werden von den Saugköpfen der "Pick and Place"-Einheit (Aufnahmeelement) des Moduls 2 an die Carrier übergeben, indem die Folien in den Aufnahmebohrungen der Carrier abgesetzt werden. Dabei werden die Folien auf den Carriern zentriert. Die Aufnahmebohrungen der Carrier sind leicht konisch, so dass eine weitere Zentrierung der Folien gewährleistet ist. Es werden vorzugsweise 10 Carrier gleichzeitig mit Folien beladen. Nach der Beladung der Carrier, welche sich auf Bahn 1 befinden, werden die mit Folien beladenen Carrier vorzugsweise sensorisch kontrolliert. Damit wird überwacht, ob alle Carrier auch tatsächlich mit einer Folie beladen sind. Sowie die 10 Carrier bestückt sind, öffnet ein Stopper die Bahn 1 und die 10 Carrier werden durch das permanent laufende flexible Transportband 1 in Richtung Modul 3 bewegt.It is advantageous if the "Pick and Place" unit of module 2 comprises an extendable arm and a transfer head with, for example, 10 suction cups. To take over the foils, the arm of the "pick and place" unit is brought into a position so that the transfer head of the "pick and place" unit with the 10 suction heads is located directly above the foils provided with module 1. The films are provided in particular by means of 10 feeders arranged in series, so that 10 films can be taken over at the same time. By vacuum, the films are sucked by the suction heads of the "Pick and Place" unit. The diameter of the suction heads at the contact surface to the film corresponds approximately to the diameter of the films. Due to the vacuum, the films lie over the entire surface on the front side of the Saufkopfes and are not deformed. The contact surface may have a shallow recess to additionally center the films. The transfer head of the "pick and place" unit of module 2 lifts the films out of the carrier tape and brings the films to, for example, ten waiting carriers, which are located on a conveyor belt 1. According to the invention, at least one conveyor belt with at least two webs is used and the receiving element of module 2 is alternately fed the carriers on web 1 and web 2 with films. The films are transferred from the suction heads of the "pick and place" unit (receiving element) of the module 2 to the carrier by the films are deposited in the receiving bores of the carrier. The films are centered on the carriers. The mounting holes of the carriers are slightly conical, so that a further centering of the films is ensured. Preferably 10 carriers are loaded simultaneously with films. After loading the carriers, which are located on track 1, the carriers loaded with films are preferably controlled by sensors. This monitors whether all carriers are actually loaded with a foil. As soon as the 10 carriers are loaded, a stopper opens the web 1 and the 10 carriers are moved in the direction of module 3 by the permanently running flexible conveyor belt 1.
Von Vorteil ist, dass nach der Beladung der auf Bahn 1 des Transportbandes 1 befindlichen Carrier, weitere Carrier auf Bahn 2 des Transportbandes 1 in die Übernahmeposition des Moduls 2 gebracht werden können. Die Carrier auf Bahn 2 stehen damit zur Beladung mit Folien bereit. Dazu übernimmt die "Pick and Place"-Einheit des Moduls 2 die nächsten 10 Folien von Modul 1 und übergibt die Folien an die Carrier, welche sich auf Bahn 2 des Transportbandes 1 in der Übernahmeposition befinden. Nachdem diese Carrier auf Bahn 2 beladen wurden, werden diese beladenen Carrier ebenfalls durch das permanent laufende flexible Transportband 1 in Richtung Modul 3 bewegt. So werden im Sekundentakt nacheinander jeweils 10 Carrier auf Bahn 1 und Bahn 2 mit Folien bestückt. Nach der Ladestation prüfen zwei optische Sensoren, ob alle Carrier in Bahn 1 und Bahn 2 mit Folien bestückt sind.It is advantageous that, after loading the carrier located on web 1 of the conveyor belt 1, further carriers can be brought to web 2 of the conveyor belt 1 in the transfer position of the module 2. The carriers on lane 2 are thus ready for loading with films. For this purpose, the "Pick and Place" unit of module 2 takes over the next 10 films of module 1 and transfers the films to the carriers, which are on web 2 of the conveyor belt 1 in the transfer position. After these carriers were loaded on lane 2, these loaded carriers are also moved by the permanently running flexible conveyor belt 1 in the direction of module 3. Thus, in each case 10 carriers are successively loaded on web 1 and web 2 with films every second. After the charging station, two optical sensors check whether all carriers in lane 1 and lane 2 are equipped with foils.
Es ist bevorzugt, dass bei Verwendung eines zweispurigen Transportbandes die Carrier von beiden Bahnen auf eine Bahn zusammengeführt werden und bei fehlender Beladung der Carrier mit einer Folie, die Carrier mittels Weiche auf ein zweites Transportband geschoben werden, welches die leeren Carrier zum erneuten Beladen der Carrier mit Folien bereitstellt.It is preferred that when using a two-lane conveyor belt, the carriers of both tracks are brought together on a web and in the absence of loading the carrier with a film, the carriers are pushed by a switch on a second conveyor belt, the empty carrier to reload the carrier with slides.
Bevorzugt ist, wenn die Carrier aus Edelstahl bestehen, damit sie mit dem nötigen Gewicht stabil auf dem Transportband stehen. Die Einsätze am Oberteil der Carrier sind insbesondere aus weißem FDA-zugelassenem Kunststoff. Die Folien wiederum sind beispielsweise dunkel eingefärbt, so dass ein deutlicher Kontrast zu den weißen Einsätzen besteht. Das erleichtert den Sensoren die eingelegten Folien sicher zu erkennen. Sollten in einzelnen Carriern Folien fehlen, gibt es eine Meldung darüber und man kann prüfen, ob die Störung an den Feedern von Modul 1 liegt oder an einzelnen Saugköpfen der "Pick and Place"-Einheit von Modul 2.It is preferred if the carriers are made of stainless steel, so that they are stable with the necessary weight on the conveyor belt. The inserts on the upper part of the carrier are made of white FDA-approved plastic. The slides in turn For example, they are colored dark, so that there is a clear contrast to the white inserts. This makes it easier for the sensors to reliably detect the inserted foils. If slides are missing in individual carriers, there is a message about this and you can check whether the fault is due to the feeders of module 1 or to individual suction heads of the "Pick and Place" unit of module 2.
Es hat sich als vorteilhaft erwiesen, dass die beladenen Carrier mit dem Transportband 1 in Richtung Modul 3 transportiert werden. Von Vorteil ist, dass das Transportband 1 so angeordnet ist, dass auf der zur "Pick and Place"-Einheit gegenüberliegenden Transportbandseite die Carrier der beiden Bahnen 1 und 2 aufgestaut und wechselseitig auf eine Bahn freigegeben bzw. zusammengeführt werden. Dadurch geht der getaktete Transport der Carrier in einen kontinuierlichen Transport über.It has proved to be advantageous for the loaded carriers to be transported with the conveyor belt 1 in the direction of module 3. It is advantageous that the conveyor belt 1 is arranged so that the carrier of the two webs 1 and 2 are dammed and mutually released on a web on the conveyor belt side opposite to the "pick and place" unit. As a result, the clocked transport of the carrier goes into a continuous transport.
Bevorzugt ist, wenn Modul 2 ein Einlaufrad umfasst, welches einen Abstand zwischen den Carriern einstellt und die Carrier mit den Folien kontinuierlich an Modul 3 übergibt. Vorteilhaft ist, dass das Modul 3 im Gegensatz zu den Feedern von Modul 1 und der "Pick and Place"-Einheit von Modul 2 kontinuierlich arbeitet. Modul 3 stellt insbesondere ein Folien-Einpressmodul dar, welches synchron und kontinuierlich mit dem Rotor der Tablettenpresse läuft. Von Vorteil ist, dass Modul 2 einen Ausgleich zwischen der getakteten Arbeitsweise der Folien-Übernahme von Modul 1 und der kontinuierlichen Arbeitsweise bei der Folien-Übergabe durch Modul 3 an die Tablettenpresse realisiert. Vorzugsweise werden die Folien getaktet von dem Aufnahmeelement des Moduls 2 übernommen und von Modul 3 in kontinuierlicher Arbeitsweise in die Matrizen der Tablettenpresse eingelegt.It is preferred if module 2 comprises an inlet wheel, which adjusts a distance between the carriers and continuously transfers the carrier with the films to module 3. It is advantageous that the module 3, in contrast to the feeders of module 1 and the "pick and place" unit of module 2 works continuously. Module 3 in particular represents a film press-in module which runs synchronously and continuously with the rotor of the tablet press. An advantage is that module 2 realizes a balance between the clocked operation of the film acquisition of module 1 and the continuous operation in the film transfer by module 3 to the tablet press. Preferably, the films are taken clocked by the receiving element of the module 2 and inserted by module 3 in a continuous operation in the dies of the tablet press.
Weiter bevorzugt ist, dass die Folien von der Übernahme durch das Aufnahmeelement von Modul 2 bis zum Einlegen in die Matrizen der Tablettenpresse mittels Carrier zentrisch geführt oder durch zentrischen Formschluss an den Vakuumköpfen transportiert werden.It is further preferred that the films are guided centrally from the takeover by the receiving element of module 2 until they are placed in the matrices of the tablet press by means of carriers or transported by centric positive engagement on the vacuum heads.
Es ist des Weiteren bevorzugt, wenn neben dem Transportband 1 ein weiteres Transportband 2 vorhanden ist. Die beiden Transportbänder sich beispielsweise über eine Weiche miteinander verbunden. Vor der Weiche zum Transportband 2 befindet sich ein weiterer optischer Sensor der das Vorhandensein einer Folien auf dem Carrier kontrolliert. Ist keine Folie in der Aufnahmebohrung des Carriers vorhanden, wird der Carrier von Transportband 1 auf Transportband 2 geschoben und automatisch über eine zweite Weiche zur Ladestation zurück transportiert. Die Ladestation ist die Station, wo die Folien mittels "Pick and Place"-Einheit an die Carrier übergeben werden. Es werden somit nur beladene Carrier kontinuierlich zum Modul 3, der sogenannten Übernahme- und Einpressstation weitergeleitet.It is further preferred if, in addition to the conveyor belt 1, a further conveyor belt 2 is present. The two conveyor belts, for example, connected to each other via a switch. Before the switch to the conveyor belt 2 is another optical sensor which controls the presence of a film on the carrier. If there is no foil in the receiving bore of the carrier, the carrier is pushed by conveyor belt 1 on conveyor belt 2 and automatically transported back to the charging station via a second switch. The charging station is the station where the films are transferred to the carriers by means of a "pick and place" unit. Thus, only loaded carriers are continuously forwarded to module 3, the so-called takeover and press-in station.
Es hat sich als Vorteil erwiesen, wenn das Modul 2 ein Einlaufrad und ein Auslaufrad umfasst. Durch die Mulden im Einlaufrad werden die Carrier auf den Stichabstand der Übernahme-/Übergabeköpfe von Modul 3 gebracht. Zwischen dem Einlaufrad und dem Auslaufrad übernehmen die Übernahme-/Übergabeköpfe von Modul 3 den Transport der Carrier. Wie bei der "Pick and Place"-Einheit von Modul 2, umfasst auch Modul 3 Saugköpfe. Mittels einer Steuerkurve fahren die Saugköpfe nach unten und übernehmen die Folien von den Carriern mittels Vakuum. Bevorzugt ist, dass die Folien bei der Übernahme durch Modul 3 zentriert werden. Bevorzugt ist weiter, dass leere Carrier dem Modul 2, nach Entnahme der Folien durch Modul 3 oder durch Absaugung, mittels mindestens eines Auslaufrades zugeführt werden und für eine erneute Beladung mit Folien bereitgestellt werden.It has proved to be advantageous if the module 2 comprises an inlet wheel and an outlet wheel. Through the recesses in the inlet wheel, the carriers are brought to the stitch spacing of the transfer / transfer heads of module 3. Between the inlet wheel and the outlet wheel, the transfer / transfer heads of module 3 take over the transport of the carriers. As with the "Pick and Place" unit of module 2, module 3 also includes suction cups. By means of a control cam drive the suction heads down and take the slides from the carriers by means of vacuum. It is preferred that the films are centered in the acquisition by module 3. It is further preferred that empty carriers are supplied to the module 2, after removal of the films by module 3 or by suction, by means of at least one outlet wheel and are provided for a new loading with films.
Bevorzugt ist, dass Sensoren die Entnahme der Folien von den Carriern durch Modul 3 überprüfen. Bevorzugt ist auch, dass eine Folie abgesaugt wird, die durch Modul 3 nicht entnommen wurde und sich nach passieren von Modul 3 noch im Carrier befindet. Auch bei Modul 3 entspricht die Kontaktfläche der Saugköpfe dem Durchmesser der Folien. Nachdem die Vakuumköpfe (Saugköpfe) von Modul 3 die Folien von den Carriern entnommen haben, werden die Vakuumköpfe (Saugköpfe) mit den Folien wieder nach oben gefahren. Die leeren Carrier werden an das Auslaufrad übergeben und dem Transportband 1 zugeführt. Hier befindet sich ein optischer Sensor, der prüft, ob im Carrier eine Folie verblieben ist und eventuell nicht durch die Saugköpfe von Modul 3 übernommen wurde. Sollte das der Fall sein, wird die im Carrier verbliebene Folie automatisch mit einer Düse abgesaugt. Dadurch wird verhindert, dass ein Carrier mit einer Folien in die Ladestation gelangt und dort mit einer zusätzlichen Folien bestückt werden könnte.It is preferred that sensors check the removal of the films from the carriers by module 3. It is also preferred that a film is sucked off, which was not removed by module 3 and is still in the carrier after passing through module 3. Also in module 3, the contact surface of the suction cups corresponds to the diameter of the films. After the vacuum heads (suction heads) of module 3 have removed the films from the carriers, the vacuum heads (suction heads) with the films are driven upwards again. The empty carriers are transferred to the discharge wheel and fed to the conveyor belt 1. Here is an optical sensor that checks whether a film has remained in the carrier and possibly has not been taken over by the suction heads of module 3. If this is the case, the foil remaining in the carrier is automatically sucked off with a nozzle. This prevents a carrier with a film in the charging station and there could be equipped with an additional film.
Bevorzugt ist, wenn die Vakuumköpfe von Modul 3 in der der Übernahme durch Modul 2 gegenüberliegenden Position auf dem Teilkreis der Matrize der Tablettenpresse synchron mit der Matrizenposition mitfahren. Nachdem die Vakuumköpfe des Moduls 3 (Übernahme-/Übergabe Modul zum Einlegen der Folien in die Matrizen einer Tablettenpresse) die Folien vom Carrier übernommen haben, bewegen sich die beweglichen Arme zur Matrizenplatte der Tablettenpresse (Rundlaufpresse). Die Drehgeschwindigkeit von Modul 3 wird synchron durch die Rotorgeschwindigkeit der Tablettenpresse gesteuert. Wenn die Arme von Modul 3 den Teilkreis der Tablettenpresse (Rundlaufpresse) überschneidend erreichen, werden sie über eine Steuerkurve zurückgezogen, so dass sich die Vakuumköpfe mit den Folien über einen gewissen Bereich auf dem Teilkreis der Rundlaufpresse oberhalb der Matrizenbohrungen befinden. Mittels einer Steuerkurve werden die Köpfe nach unten gedrückt, so dass die Vakuumköpfe mit den Folien in die Matrizenbohrungen eintauchen und so die Scheiben insbesondere in das Pressmaterial einer ersten Pulverschicht gedrückt werden können. Das Vakuum wird abgeschaltet und ein nachfolgender leichter Druckluftstoß gewährleistet, dass die Folien nicht am Saugkopf haften bleiben. Anschließend verlassen die Vakuumköpfe die Matrizenbohrungen, werden über die Steuerkurve auf den alten Teilkreis zurückgefahren, die Vakuumleitungen werden mit einem kräftigen Druckluftstoß freigeblasen, und sie übernehmen anschließend die nächsten Folien von den Carriern. Auf diese Weise werden die Folien einzeln in die Matrizen der Tablettenpresse eingelegt.It is preferred if the vacuum heads of module 3 in the position opposite the takeover by module 2 on the pitch circle of the matrix of the tablet press move in synchronism with the die position. After the vacuum heads of the module 3 (transfer / transfer module for inserting the slides into the matrices a tablet press) have taken over the films from the carrier, the movable arms move to the die plate of the tablet press (rotary press). The rotational speed of module 3 is controlled synchronously by the rotor speed of the tablet press. When the arms of module 3 reach the pitch of the tablet press (rotary press) overlapping, they are retracted via a control cam, so that the vacuum heads with the films over a certain area on the pitch circle of the rotary press are located above the die holes. By means of a control cam, the heads are pressed down so that the vacuum heads dive with the films in the die holes and so the discs can be pressed in particular in the press material of a first layer of powder. The vacuum is switched off and a subsequent slight blast of compressed air ensures that the films do not stick to the suction head. Subsequently, the vacuum heads leave the die holes, are returned to the old pitch circle via the control cam, the vacuum lines are blown open with a powerful blast of compressed air, and then take over the next foils from the carriers. In this way, the films are individually placed in the dies of the tablet press.
Für die Herstellung von Manteltabletten, bei denen eine Folie mit komprimiertem Pulver ummantelt wird, ist es bevorzugt, wenn die Tablettenpresse, zwei Pulverfüllgeräte und zwei Andrückstationen umfasst. Es ist ein Vorteil, wenn sich links und rechts von Modul 3 je eine Andrückstation befindet. Mit der Andrückstation 1 wird das in der Matrize vorgelegte Pulver (Pressmaterial) der ersten Schicht leicht angepresst, um das Material zu entlüften und um eine glatte Oberfläche zu erhalten. Anschließend wird die Folie über das Modul 3 automatisch und kontinuierlich in die Matrize eingebracht. Bevorzugt ist, dass die Folien zentrisch in die Matrizen der Tablettenpresse eingelegt werden.For the production of coated tablets, in which a film is coated with compressed powder, it is preferred if the tablet press comprises two powder filling devices and two pressing stations. It is an advantage if one pressing station is located to the left and right of module 3. With the pressing station 1, the powder (pressing material) of the first layer, which has been placed in the matrix, is pressed lightly in order to vent the material and to obtain a smooth surface. Subsequently, the film via the module 3 is automatically and continuously introduced into the die. It is preferred that the films are inserted centrally into the dies of the tablet press.
Vorzugsweise arbeitet der Drehteller des Moduls 3 synchron mit der Arbeitsgeschwindigkeit des Rotors der Tablettenpresse, so dass die Folien kontinuierlich in die Matrizen eingelegt werden. Die Folien werden auf der ersten komprimierten Pulverschicht abgelegt. Mit der 2. Andrückstation wird die Folie leicht angedrückt und in die erste Pulverschicht eingepresst. Dabei wird mit der zweiten Andrückstation gleichzeitig die erste Schicht mit der eingelegten Folie in die Füllposition für die zweite Pulverschicht geschoben. Es entsteht damit ein Füllraum für die zweite Pulverschicht (Deckschicht). Der entstandene Hohlraum wird dann mit dem zweiten Füllschuh und beispielsweise dem gleichen Pressmaterial aufgefüllt wie beim Vorlegen der ersten Pulverschicht in der Matrize. Anschließend wird das Pressmaterial mittels der Ober- und Unterstempel und mit Hilfe des Vor- und Hauptpressdruckes zu einer Manteltablette gepresst. Die Manteltablette wird ausgestoßen und mit dem Tablettenabstreifer über die Ablaufrutsche aus der Tablettenpresse geleitet. Vorteilhaft ist, dass das Einlegen empfindlicher Folien in die Matrizen einer Tablettenpresse, um die Folien so in einer Manteltablette einzubetten, nicht mehr wie im Stand der Technik von Hand erfolgen muss, sondern mit der Durchführung des erfindungsgemäßen Verfahrens automatisiert ablaufen kann. Dies führt vorteilhafter Weise zu wirtschaftlichen Prozessen, bei denen die Qualität reproduzierbar ist und eine Effizienzsteigerung erzielt wird.Preferably, the turntable of the module 3 operates synchronously with the operating speed of the rotor of the tablet press, so that the films are continuously inserted into the matrices. The films are deposited on the first compressed powder layer. With the second pressing station, the film is lightly pressed and pressed into the first powder layer. At the same time, with the second pressing station, the first layer with the inserted foil is simultaneously pushed into the filling position for the second powder layer. This creates a filling space for the second powder layer (Top layer). The resulting cavity is then filled with the second filling shoe and, for example, the same pressing material as in the presentation of the first powder layer in the die. Subsequently, the press material is pressed by means of the upper and lower punches and with the help of the pre-press and the main press to a coated tablet. The coated tablet is ejected and passed with the tablet scraper over the chute from the tablet press. It is advantageous that the insertion of sensitive films in the matrices of a tablet press in order to embed the films in a coated tablet, no longer needs to be done by hand as in the prior art, but can run automatically with the implementation of the method according to the invention. This leads advantageously to economic processes in which the quality is reproducible and an increase in efficiency is achieved.
Weitere vorteilhafte Maßnahmen sind in den übrigen Unteransprüchen enthalten. Die Erfindung wird nunmehr anhand der Figuren beispielhaft beschrieben. Bei den Beispielen und Figuren handelt es sich um bevorzugte Ausführungsvarianten welche die Erfindung nicht beschränken.
- Figur 1
- Modul 1
- Figur 2
- Modul 2
- Figur 3
- Modul 3
- Figur 4
- Tablettenpresse
- Figur 5
- Vorrichtung umfassend Modul 1, Modul 2, Modul 3 und Tablettenpresse
- Figur 6
- Carrier mit Aufnahme Bohrung
- FIG. 1
- Module 1
- FIG. 2
- Module 2
- FIG. 3
- Module 3
- FIG. 4
- tablet press
- FIG. 5
- Device comprising module 1, module 2, module 3 and tablet press
- FIG. 6
- Carrier with pickup hole
Die Carrier (28) wurden vor der Bereitstellung sensorisch (20) überprüft, ob die Carrier (28) auch nicht bereits mit einer Folie beladen sind. Nur leere Carrier (28) werden zur Beladung mit Folien bereitgestellt. Nach der Beladung wir ein Stopper geöffnet und die mit Folien beladenen Carrier (28) werden auf dem permanent laufenden Transportband 1 (17) bewegt. In
Claims (14)
- A method for transferring, inserting and positioning films, which are used as core for a coat-core tablet, in dies of tablet presses,
wherein the method comprises the following method steps,a. provision of the films by means of module 1 (11), which brings the films into the takeover position,b. takeover of the films by module 2 (12), wherein the module 2 (12) receives the films by means of a receiving element (16),c. placing of the films on carriers (28) by module 2 (12), wherein the films are centered on the carriers (28),d. transporting of the carriers (28) to the module 3 (13), wherein the loading of the carriers (28) is monitored by sensor,e. takeover of the films by module 3 (13) by means of vacuum heads (25),f. positioning of the films in the dies of the tablet press (14), wherein the films are inserted, andat least one conveyor belt (17) with at least two lanes (18a, 19) is used, and the receiving element (16) of module 2 (12) alternately provides the carrier (28) on lane 1 (18a) and lane 2 (19) with films. - A device for transferring, inserting and positioning films, which are used as core for a coat-core tablet, in dies of tablet presses,
wherein the device comprises at least three modules,a. module 1 (11), comprising at least one supply unit, which contains the films, and/or at least one provision unit which provides the films for takeover by a second module,b. module 2 (12) comprising at least one takeover unit, at least one conveyor belt (17) and at least one inlet wheel (22), wherein the module 2 (12)i. takes over the films from module 1 (11) by means of receiving element (16)ii. places the films on carriers (28),iii. transports the carriers (28),iv. by means of inlet wheel (22), sets a distance between the carriers (28),c. module 3 (13), comprising at least one vacuum head (25) which comprises a removal device which removes the films from the carriers (28) of the module 2 (12) and inserts them into the dies of the tablet press (14). - The method according to Claim 1,
characterized in that
the films are an information carrier, a separation layer and/or an active ingredient carrier, wherein the films are light, limp, compliant, flexible, rigid and/or loadable. - The method according to Claim 1 or 3,
characterized in that
the method steps of provision of the films by means of module 1 (11) and/or takeover of the films by module 2 (12) are discontinuous. - The method according to Claim 1 or 4,
characterized in that
module 2 (12) comprises an inlet wheel (22), which sets a distance between the carriers (28) and which transfers the carriers (28) with the films continuously to module 3 (13). - The method according to Claim 1 or 5,
characterized in that
the films are taken over in synchronized manner by the receiving element (16) of the module 2 (12) and are inserted by module 3 (13) in a continuous operating mode into the dies of the tablet press (14). - The method according to one or more of the preceding claims,
characterized in that,
if a two-lane conveyor belt (17) is used, the carriers (28) of the two lanes (18a, 19) are led together to one lane (18b), and in the case of absence of loading of the carriers (28) with a film, the carriers (28) are shifted by means of a shunt(24a) to a second conveyor belt (21), which provides the empty carriers (28) with films for renewed loading of the carriers (28). - The method according to one or more of the preceding claims,
characterized in that,
the films are led centrally by means of carrier (28) or transported by central positive locking connection on the vacuum heads (25) from the takeover by the takeover unit of module 2 (12) to the insertion into the dies of the tablet press (14). - The method according to Claim 1 or 8,
characterized in that
the vacuum heads (25) of module 3 (13), in the position facing the takeover by module 2 (12), move along on the pitch circle of the die of the tablet press (14) synchronously with the die position. - The method according to Claim 1 or 9,
characterized in that,
after the removal of the films by module 3 (13) or by suction, empty carriers (28) are supplied to the module 2 (12) by means of at least one outlet wheel (23) and are provided with films for renewed loading. - The device according to Claim 2,
characterized in that
module 2 (12) comprises the following units which are selected from the group consisting of takeover units, receiving elements (16), conveyor belts (17, 21), deflection wheels, guide rails, spacers, stop bars, control sensors, inlet wheels (22), outlet wheels (23) and/or shunts (24a, 24b). - The device according to Claim 2 or 11,
characterized in that,
as receiving unit element (16), the takeover unit of module 2 (12) comprises a takeover head with up to 50 vacuum heads, preferably with up to 30 vacuum heads, more preferably with up to 20 vacuum heads and most preferably with up to 10 vacuum heads. - The device according to Claim 2 or 12,
characterized in that
module 3 (13) comprises vacuum heads (25), movable arms, at least two control cams, pressurized air connections and/or vacuum connections, wherein the vacuum heads (25) can be lowered and are immersed in dies of the tablet press (14). - The device according to Claim 2 or 13,
characterized in that
the speed of rotation of module 3 (13) can be set variably and synchronously with the rotor speed of the tablet press (14).
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES13176062.1T ES2637382T3 (en) | 2013-07-11 | 2013-07-11 | Device and procedure for inserting films into tablet presses |
EP13176062.1A EP2823799B1 (en) | 2013-07-11 | 2013-07-11 | Device and method for inserting films in tablet presses |
PCT/EP2014/060130 WO2014184364A1 (en) | 2013-05-16 | 2014-05-16 | Device and method for depositing films in tablet presses |
IN9338DEN2014 IN2014DN09338A (en) | 2013-05-16 | 2014-05-16 | |
CN201811064402.2A CN109228493B (en) | 2013-05-16 | 2014-05-16 | Method for transferring, inserting and positioning a film in the die of a tablet press |
JP2015516651A JP5866483B2 (en) | 2013-05-16 | 2014-05-16 | Apparatus and method for inserting film into tablet press |
CN201480001715.7A CN104411283B (en) | 2013-05-16 | 2014-05-16 | Device and method for being placed on film in tablet press machine |
KR1020147033367A KR101648660B1 (en) | 2013-05-16 | 2014-05-16 | Device and method for depositing films in tablet presses |
US14/403,582 US9248621B2 (en) | 2013-05-16 | 2014-05-16 | Apparatus and method for the insertion of films in tablet presses |
JP2016000069A JP6156955B2 (en) | 2013-05-16 | 2016-01-04 | Apparatus and method for inserting film into tablet press |
US14/990,977 US9452583B2 (en) | 2013-05-16 | 2016-01-08 | Apparatus and method for the insertion of films in tablet presses |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13176062.1A EP2823799B1 (en) | 2013-07-11 | 2013-07-11 | Device and method for inserting films in tablet presses |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2823799A1 EP2823799A1 (en) | 2015-01-14 |
EP2823799B1 true EP2823799B1 (en) | 2017-05-17 |
Family
ID=48783006
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP13176062.1A Active EP2823799B1 (en) | 2013-05-16 | 2013-07-11 | Device and method for inserting films in tablet presses |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP2823799B1 (en) |
ES (1) | ES2637382T3 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017211520A1 (en) * | 2016-06-08 | 2017-12-14 | Schunk Kohlenstofftechnik Gmbh | Device and method for producing a compression moulded body |
DE102016211290B4 (en) * | 2016-06-08 | 2018-07-19 | Schunk Kohlenstofftechnik Gmbh | Apparatus and method for producing a molded article |
EP3599087A1 (en) * | 2018-07-25 | 2020-01-29 | Korsch AG | Device for providing inserts to a tableting machine and a method for producing a pressed article having an insert |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3836299A (en) * | 1973-08-13 | 1974-09-17 | Fmc Corp | Press for forming one-piece tablet containing seeds or the like |
US5088915A (en) * | 1988-06-08 | 1992-02-18 | Korsch Ohg Maschinenfabrik | Coated-core press |
JPH09271996A (en) * | 1996-04-05 | 1997-10-21 | Sankyo Co Ltd | Device for automatically forming tablet |
EP1944008A3 (en) * | 2004-09-24 | 2008-07-23 | BioProgress Technology Limited | Additional improvements in powder compaction and enrobing |
DE102007039043A1 (en) * | 2007-08-17 | 2009-02-19 | Grünenthal GmbH | star Hub |
EP2110232B1 (en) * | 2008-04-18 | 2016-09-14 | Korsch AG | Device for inserting inlays into the matrices of a rotary tablet press |
-
2013
- 2013-07-11 ES ES13176062.1T patent/ES2637382T3/en active Active
- 2013-07-11 EP EP13176062.1A patent/EP2823799B1/en active Active
Also Published As
Publication number | Publication date |
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EP2823799A1 (en) | 2015-01-14 |
ES2637382T3 (en) | 2017-10-13 |
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