EP2776399A1 - Substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with an n-containing group as vanilloid receptor ligands - Google Patents
Substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with an n-containing group as vanilloid receptor ligandsInfo
- Publication number
- EP2776399A1 EP2776399A1 EP12781341.8A EP12781341A EP2776399A1 EP 2776399 A1 EP2776399 A1 EP 2776399A1 EP 12781341 A EP12781341 A EP 12781341A EP 2776399 A1 EP2776399 A1 EP 2776399A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- methyl
- phenyl
- pyrazol
- fluoro
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Virology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12781341.8A EP2776399A1 (en) | 2011-11-09 | 2012-11-08 | Substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with an n-containing group as vanilloid receptor ligands |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11008913 | 2011-11-09 | ||
EP12781341.8A EP2776399A1 (en) | 2011-11-09 | 2012-11-08 | Substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with an n-containing group as vanilloid receptor ligands |
PCT/EP2012/072141 WO2013068462A1 (en) | 2011-11-09 | 2012-11-08 | Substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with an n-containing group as vanilloid receptor ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
EP2776399A1 true EP2776399A1 (en) | 2014-09-17 |
Family
ID=47143123
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP12781341.8A Withdrawn EP2776399A1 (en) | 2011-11-09 | 2012-11-08 | Substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with an n-containing group as vanilloid receptor ligands |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP2776399A1 (ja) |
JP (1) | JP2014532742A (ja) |
KR (1) | KR20140096351A (ja) |
CN (1) | CN103906736A (ja) |
AR (1) | AR088701A1 (ja) |
AU (1) | AU2012334066A1 (ja) |
BR (1) | BR112014010957A2 (ja) |
CA (1) | CA2854935A1 (ja) |
HK (1) | HK1202116A1 (ja) |
IN (1) | IN2014KN00847A (ja) |
MX (1) | MX2014005611A (ja) |
TW (1) | TW201326134A (ja) |
WO (1) | WO2013068462A1 (ja) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101909092B1 (ko) | 2014-11-24 | 2018-10-17 | (주) 메디프론디비티 | 바닐로이드 수용체 리간드 ii로서의 치환된 옥사졸계 및 싸이아졸계 카복스아미드 및 우레아 유도체 |
CN114920697A (zh) * | 2022-05-16 | 2022-08-19 | 河南应用技术职业学院 | 杂环基取代的茚满丙酰胺类化合物及其应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1020447A4 (en) * | 1997-09-11 | 2000-11-15 | Nissan Chemical Ind Ltd | PYRAZOLE-BASED COMPOUNDS AND PLANT DISEASE CONTROL AGENT |
AU2006303437B2 (en) * | 2005-10-19 | 2012-06-28 | Grunenthal Gmbh | Novel vanilloid receptor ligands and their use for producing medicaments |
CN101679297B (zh) * | 2006-12-08 | 2012-01-11 | 埃克塞利希斯股份有限公司 | Lxr和fxr调节剂 |
BRPI0810035A2 (pt) * | 2007-04-16 | 2016-07-26 | Gruenenthal Gmbh | ligantes de receptor de vaniloide e seu uso para produção de medicamento |
DE102007018151A1 (de) * | 2007-04-16 | 2008-10-23 | Günenthal GmbH | Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
SI2427436T1 (sl) * | 2009-05-07 | 2013-04-30 | Grunenthal Gmbh | Substituirani aromatski karboksamidni in sečninski derivati kot ligandi vaniloidnega receptorja |
AR076752A1 (es) | 2009-05-07 | 2011-07-06 | Gruenenthal Chemie | Fenilureas y fenilamidas sustituidas como ligandos del receptor de vanilloides. |
WO2013068463A1 (en) * | 2011-11-09 | 2013-05-16 | Grünenthal GmbH | Substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with an n-cyclic group as vanilloid receptor ligands |
-
2012
- 2012-11-08 AR ARP120104203A patent/AR088701A1/es unknown
- 2012-11-08 BR BR112014010957A patent/BR112014010957A2/pt not_active IP Right Cessation
- 2012-11-08 IN IN847KON2014 patent/IN2014KN00847A/en unknown
- 2012-11-08 TW TW101141482A patent/TW201326134A/zh unknown
- 2012-11-08 WO PCT/EP2012/072141 patent/WO2013068462A1/en active Application Filing
- 2012-11-08 CN CN201280055195.9A patent/CN103906736A/zh active Pending
- 2012-11-08 JP JP2014540454A patent/JP2014532742A/ja active Pending
- 2012-11-08 MX MX2014005611A patent/MX2014005611A/es not_active Application Discontinuation
- 2012-11-08 KR KR1020147015425A patent/KR20140096351A/ko not_active Application Discontinuation
- 2012-11-08 EP EP12781341.8A patent/EP2776399A1/en not_active Withdrawn
- 2012-11-08 AU AU2012334066A patent/AU2012334066A1/en not_active Abandoned
- 2012-11-08 CA CA2854935A patent/CA2854935A1/en not_active Abandoned
-
2015
- 2015-03-13 HK HK15102577.0A patent/HK1202116A1/xx unknown
Non-Patent Citations (1)
Title |
---|
See references of WO2013068462A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU2012334066A1 (en) | 2014-05-22 |
TW201326134A (zh) | 2013-07-01 |
AR088701A1 (es) | 2014-06-25 |
CN103906736A (zh) | 2014-07-02 |
KR20140096351A (ko) | 2014-08-05 |
IN2014KN00847A (ja) | 2015-10-02 |
WO2013068462A1 (en) | 2013-05-16 |
HK1202116A1 (en) | 2015-09-18 |
JP2014532742A (ja) | 2014-12-08 |
MX2014005611A (es) | 2014-07-30 |
BR112014010957A2 (pt) | 2017-06-06 |
CA2854935A1 (en) | 2013-05-16 |
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