EP2768544A1 - Systeme de gelification in situ absorbable, son procede de fabrication et son utilisation - Google Patents
Systeme de gelification in situ absorbable, son procede de fabrication et son utilisationInfo
- Publication number
- EP2768544A1 EP2768544A1 EP20110874179 EP11874179A EP2768544A1 EP 2768544 A1 EP2768544 A1 EP 2768544A1 EP 20110874179 EP20110874179 EP 20110874179 EP 11874179 A EP11874179 A EP 11874179A EP 2768544 A1 EP2768544 A1 EP 2768544A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- forming composition
- situ gel
- group
- composition
- lactide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0031—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0042—Materials resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
Definitions
- polyoxyalkylene glycol chain has an average molecular weight of 200-1200 dalton.
- the polyoxyalkylene glycol chain is PEG 200, PEG 300, PEG 400, PEG 500, PEG 600, PEG 700, PEG 800, PEG 900, PEG 1000, and derivatives thereof.
- the polyester or polyester-carbonate chain segments are derived from at least one cyclic monomer selected from the group represented by ⁇ -caprolactone, trimethylene carbonate, p-dioxanone, 1 ,5- dioxepan-2-one, 1-lactide, dl-lactide, glycolide, morpholinedione, and combinations thereof.
- the aliphatic urethane segments are derived from at least one diisocyanate selected from the group consisting of hexamethylene diisocyanate, lysine-derived diisocyanate, and
- the in situ gel-forming composition forms a hydrogel or semi-solid mass at a treatment site within 15 seconds, 30 seconds, 60 seconds or 90 seconds.
- the gelation time is determined visually by observing the period between injection and formation of the solid mass.
- the diluent/solvent portion of the solution precipitates leaving the hardened polymeric hydrogel or semi-solid mass that can be visually detected.
- the rate of gelation may be adjusted by adding one or more gelation accelerators to the in situ gel-forming composition.
- Compounds that may serve as gelation accelerators include, but are not limited to, collagen, thrombin, activated platelets, chitosan, fibrinogen and antifibrinolytics.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Materials Engineering (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Surgery (AREA)
- Dermatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2011/056537 WO2013058726A1 (fr) | 2011-10-17 | 2011-10-17 | Système de gélification in situ absorbable, son procédé de fabrication et son utilisation |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2768544A1 true EP2768544A1 (fr) | 2014-08-27 |
EP2768544A4 EP2768544A4 (fr) | 2015-06-24 |
Family
ID=48141188
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP11874179.2A Withdrawn EP2768544A4 (fr) | 2011-10-17 | 2011-10-17 | Systeme de gelification in situ absorbable, son procede de fabrication et son utilisation |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP2768544A4 (fr) |
JP (1) | JP5989126B2 (fr) |
CN (2) | CN107252498B (fr) |
CA (1) | CA2852386C (fr) |
WO (1) | WO2013058726A1 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20150305892A1 (en) * | 2014-04-25 | 2015-10-29 | Abbott Cardiovascular Systems Inc. | Methods and Devices for Treating a Bodily Lumen with In Situ Generated Structural Support |
CN104189951B (zh) * | 2014-09-19 | 2017-06-30 | 赣南师范学院 | 一种注射用快速形成原位小分子水凝胶的液态制剂及其制备方法和应用 |
CN104383276A (zh) * | 2014-10-27 | 2015-03-04 | 济南高达信息技术有限公司 | 一种治疗蜘蛛痣的中药口服液制剂及其制备方法 |
WO2017024027A1 (fr) * | 2015-08-03 | 2017-02-09 | Tolmar International Limited | Système de distribution de polymère liquide pour l'administration prolongée de médicaments |
JP6835841B2 (ja) * | 2015-11-16 | 2021-02-24 | エボニック オペレーションズ ゲーエムベーハー | 非核酸系逆転写酵素阻害剤とポリ(ラクチド−co−グリコリド)とを含む注射液 |
WO2017192753A1 (fr) * | 2016-05-03 | 2017-11-09 | Bvw Holding Ag | Gel multiphasique |
US20220202703A1 (en) * | 2019-03-15 | 2022-06-30 | Poly-Med, Inc. | In situ gel-forming delivery systems, methods and compositions |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6413539B1 (en) * | 1996-10-31 | 2002-07-02 | Poly-Med, Inc. | Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof |
DE69636626T2 (de) * | 1995-07-28 | 2007-08-30 | Genzyme Corp., Cambridge | Biologische abbaubare multiblokhydrogene und ihre verwendung wie trägerstoffe fur kontrollierte freisetzung pharmakologisch activen werstoffe und gewebekontaktmaterialen |
EP0923399B1 (fr) * | 1996-07-29 | 2004-06-16 | Micro Therapeutics, Inc. | Ensemble de pieces pour des nouveaux procedes d'embolisation de sites vasculaires a l'aide d'une composition d'embolisation comprenant du dymethylsulfoxyde |
US5854382A (en) * | 1997-08-18 | 1998-12-29 | Meadox Medicals, Inc. | Bioresorbable compositions for implantable prostheses |
AU754003B2 (en) * | 1998-06-30 | 2002-10-31 | Amgen, Inc. | Thermosensitive biodegradable hydrogels for sustained delivery of biologically active agents |
US6245740B1 (en) * | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
EP1987847A1 (fr) * | 1999-05-21 | 2008-11-05 | Micro Therapeutics, Inc. | Nouvelles compositions d'embolisation haute viscosité |
US7649023B2 (en) * | 2002-06-11 | 2010-01-19 | Novartis Ag | Biodegradable block copolymeric compositions for drug delivery |
AU2003272011A1 (en) * | 2002-10-31 | 2004-05-25 | Pfizer Products Inc. | Solid and semi-solid polymeric ionic conjugates |
CN1950114A (zh) * | 2004-05-12 | 2007-04-18 | 苏尔莫迪克斯公司 | 用于医疗物品的天然生物可降解的多糖涂层 |
US20050255091A1 (en) * | 2004-05-14 | 2005-11-17 | Loomis Gary L | Hydrogels for biomedical applications |
CN1899264A (zh) * | 2006-07-20 | 2007-01-24 | 上海交通大学 | 温度敏感型水凝胶释药体系及其制备方法 |
CN100562358C (zh) * | 2007-05-17 | 2009-11-25 | 浙江大学 | 以水凝胶微球为模板制备中空微球的方法 |
US20090233887A1 (en) * | 2008-03-12 | 2009-09-17 | Shalaby Shalaby W | Hydroswellable, Segmented, Aliphatic Polyurethanes and Polyurethane Ureas |
CN101721349B (zh) * | 2008-10-16 | 2011-07-20 | 常州百瑞吉生物医药有限公司 | 可注射原位交联水凝胶及其制备方法和用途 |
CN102146200B (zh) * | 2011-04-19 | 2012-08-22 | 复旦大学 | 一种基于化学交联凝胶颗粒的温敏性水凝胶及其制备方法 |
-
2011
- 2011-10-17 CA CA2852386A patent/CA2852386C/fr active Active
- 2011-10-17 CN CN201710269176.0A patent/CN107252498B/zh active Active
- 2011-10-17 EP EP11874179.2A patent/EP2768544A4/fr not_active Withdrawn
- 2011-10-17 CN CN201180075605.1A patent/CN103998069A/zh active Pending
- 2011-10-17 JP JP2014537033A patent/JP5989126B2/ja active Active
- 2011-10-17 WO PCT/US2011/056537 patent/WO2013058726A1/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
CA2852386C (fr) | 2019-05-21 |
CN103998069A (zh) | 2014-08-20 |
CN107252498B (zh) | 2021-02-19 |
JP2014532082A (ja) | 2014-12-04 |
JP5989126B2 (ja) | 2016-09-07 |
CA2852386A1 (fr) | 2013-04-25 |
WO2013058726A1 (fr) | 2013-04-25 |
CN107252498A (zh) | 2017-10-17 |
EP2768544A4 (fr) | 2015-06-24 |
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Legal Events
Date | Code | Title | Description |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
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17P | Request for examination filed |
Effective date: 20140506 |
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AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
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DAX | Request for extension of the european patent (deleted) | ||
RA4 | Supplementary search report drawn up and despatched (corrected) |
Effective date: 20150527 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61M 31/00 20060101ALI20150520BHEP Ipc: A61L 24/00 20060101ALI20150520BHEP Ipc: A61L 27/14 20060101AFI20150520BHEP Ipc: A61L 27/58 20060101ALI20150520BHEP Ipc: A61L 27/54 20060101ALI20150520BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |
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17Q | First examination report despatched |
Effective date: 20180320 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20210413 |