EP2765420B1 - Nachweis von Drogen in ausgeatmeter Luft - Google Patents
Nachweis von Drogen in ausgeatmeter Luft Download PDFInfo
- Publication number
- EP2765420B1 EP2765420B1 EP14164314.8A EP14164314A EP2765420B1 EP 2765420 B1 EP2765420 B1 EP 2765420B1 EP 14164314 A EP14164314 A EP 14164314A EP 2765420 B1 EP2765420 B1 EP 2765420B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- exhaled breath
- filter membrane
- sampling unit
- subject
- housing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229940079593 drug Drugs 0.000 title claims description 15
- 239000003814 drug Substances 0.000 title claims description 15
- 238000001514 detection method Methods 0.000 title description 3
- 238000005070 sampling Methods 0.000 claims description 92
- 239000012528 membrane Substances 0.000 claims description 56
- 229940088679 drug related substance Drugs 0.000 claims description 52
- 238000000034 method Methods 0.000 claims description 29
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 24
- 150000001875 compounds Chemical class 0.000 claims description 24
- 238000012360 testing method Methods 0.000 claims description 13
- 239000002245 particle Substances 0.000 claims description 12
- 239000008280 blood Substances 0.000 claims description 9
- 210000004369 blood Anatomy 0.000 claims description 9
- 238000004949 mass spectrometry Methods 0.000 claims description 9
- 210000003296 saliva Anatomy 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 claims description 8
- 229940025084 amphetamine Drugs 0.000 claims description 8
- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 claims description 6
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims description 6
- 239000000835 fiber Substances 0.000 claims description 6
- 210000004072 lung Anatomy 0.000 claims description 6
- 229960001797 methadone Drugs 0.000 claims description 6
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims description 6
- 210000002700 urine Anatomy 0.000 claims description 6
- 229940049706 benzodiazepine Drugs 0.000 claims description 4
- 150000001557 benzodiazepines Chemical class 0.000 claims description 4
- 229940127240 opiate Drugs 0.000 claims description 4
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 claims description 3
- SHXWCVYOXRDMCX-UHFFFAOYSA-N 3,4-methylenedioxymethamphetamine Chemical compound CNC(C)CC1=CC=C2OCOC2=C1 SHXWCVYOXRDMCX-UHFFFAOYSA-N 0.000 claims description 3
- 241000218236 Cannabis Species 0.000 claims description 3
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 claims description 3
- VAYOSLLFUXYJDT-RDTXWAMCSA-N Lysergic acid diethylamide Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N(CC)CC)C2)=C3C2=CNC3=C1 VAYOSLLFUXYJDT-RDTXWAMCSA-N 0.000 claims description 3
- NPPQSCRMBWNHMW-UHFFFAOYSA-N Meprobamate Chemical compound NC(=O)OCC(C)(CCC)COC(N)=O NPPQSCRMBWNHMW-UHFFFAOYSA-N 0.000 claims description 3
- -1 Tryptamines Substances 0.000 claims description 3
- 239000003263 anabolic agent Substances 0.000 claims description 3
- 229940070021 anabolic steroids Drugs 0.000 claims description 3
- KZOKOEQTKWBKOK-XHQKLZHNSA-N azidomorphine Chemical compound O([C@H]1[C@@H](CC[C@H]23)N=[N+]=[N-])C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O KZOKOEQTKWBKOK-XHQKLZHNSA-N 0.000 claims description 3
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 claims description 3
- 229960001736 buprenorphine Drugs 0.000 claims description 3
- 229930003827 cannabinoid Natural products 0.000 claims description 3
- 239000003557 cannabinoid Substances 0.000 claims description 3
- 229940065144 cannabinoids Drugs 0.000 claims description 3
- 229960003920 cocaine Drugs 0.000 claims description 3
- XLMALTXPSGQGBX-GCJKJVERSA-N dextropropoxyphene Chemical compound C([C@](OC(=O)CC)([C@H](C)CN(C)C)C=1C=CC=CC=1)C1=CC=CC=C1 XLMALTXPSGQGBX-GCJKJVERSA-N 0.000 claims description 3
- 229960004193 dextropropoxyphene Drugs 0.000 claims description 3
- 229960002069 diamorphine Drugs 0.000 claims description 3
- 229950002454 lysergide Drugs 0.000 claims description 3
- 229960004815 meprobamate Drugs 0.000 claims description 3
- 229960005181 morphine Drugs 0.000 claims description 3
- 229920002994 synthetic fiber Polymers 0.000 claims description 3
- 229960004380 tramadol Drugs 0.000 claims description 3
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 claims description 3
- 229960004242 dronabinol Drugs 0.000 claims 2
- 239000003039 volatile agent Substances 0.000 claims 1
- 239000000523 sample Substances 0.000 description 20
- 238000004458 analytical method Methods 0.000 description 13
- 239000000443 aerosol Substances 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 239000003365 glass fiber Substances 0.000 description 5
- 239000002117 illicit drug Substances 0.000 description 5
- 229960001252 methamphetamine Drugs 0.000 description 5
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 5
- 238000004891 communication Methods 0.000 description 4
- 230000029058 respiratory gaseous exchange Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000012530 fluid Substances 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000003444 anaesthetic effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000004611 spectroscopical analysis Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 239000012855 volatile organic compound Substances 0.000 description 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- 206010013654 Drug abuse Diseases 0.000 description 1
- 238000004566 IR spectroscopy Methods 0.000 description 1
- 238000001069 Raman spectroscopy Methods 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 238000011953 bioanalysis Methods 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 239000003989 dielectric material Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 238000001294 liquid chromatography-tandem mass spectrometry Methods 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 229960005015 local anesthetics Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000006996 mental state Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- KWTSXDURSIMDCE-OABOXVCPSA-N n,n,1,1,2-pentadeuterio-3-phenylpropan-2-amine Chemical compound [2H]C([2H])C([2H])(N([2H])[2H])CC1=CC=CC=C1 KWTSXDURSIMDCE-OABOXVCPSA-N 0.000 description 1
- 230000003533 narcotic effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 238000004416 surface enhanced Raman spectroscopy Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
- G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/097—Devices for facilitating collection of breath or for directing breath into or through measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
- A61B5/412—Detecting or monitoring sepsis
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F01—MACHINES OR ENGINES IN GENERAL; ENGINE PLANTS IN GENERAL; STEAM ENGINES
- F01D—NON-POSITIVE DISPLACEMENT MACHINES OR ENGINES, e.g. STEAM TURBINES
- F01D1/00—Non-positive-displacement machines or engines, e.g. steam turbines
- F01D1/02—Non-positive-displacement machines or engines, e.g. steam turbines with stationary working-fluid guiding means and bladed or like rotor, e.g. multi-bladed impulse steam turbines
- F01D1/06—Non-positive-displacement machines or engines, e.g. steam turbines with stationary working-fluid guiding means and bladed or like rotor, e.g. multi-bladed impulse steam turbines traversed by the working-fluid substantially radially
- F01D1/08—Non-positive-displacement machines or engines, e.g. steam turbines with stationary working-fluid guiding means and bladed or like rotor, e.g. multi-bladed impulse steam turbines traversed by the working-fluid substantially radially having inward flow
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F01—MACHINES OR ENGINES IN GENERAL; ENGINE PLANTS IN GENERAL; STEAM ENGINES
- F01D—NON-POSITIVE DISPLACEMENT MACHINES OR ENGINES, e.g. STEAM TURBINES
- F01D5/00—Blades; Blade-carrying members; Heating, heat-insulating, cooling or antivibration means on the blades or the members
- F01D5/02—Blade-carrying members, e.g. rotors
- F01D5/04—Blade-carrying members, e.g. rotors for radial-flow machines or engines
- F01D5/043—Blade-carrying members, e.g. rotors for radial-flow machines or engines of the axial inlet- radial outlet, or vice versa, type
- F01D5/048—Form or construction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F05—INDEXING SCHEMES RELATING TO ENGINES OR PUMPS IN VARIOUS SUBCLASSES OF CLASSES F01-F04
- F05D—INDEXING SCHEME FOR ASPECTS RELATING TO NON-POSITIVE-DISPLACEMENT MACHINES OR ENGINES, GAS-TURBINES OR JET-PROPULSION PLANTS
- F05D2220/00—Application
- F05D2220/60—Application making use of surplus or waste energy
- F05D2220/62—Application making use of surplus or waste energy with energy recovery turbines
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F05—INDEXING SCHEMES RELATING TO ENGINES OR PUMPS IN VARIOUS SUBCLASSES OF CLASSES F01-F04
- F05D—INDEXING SCHEME FOR ASPECTS RELATING TO NON-POSITIVE-DISPLACEMENT MACHINES OR ENGINES, GAS-TURBINES OR JET-PROPULSION PLANTS
- F05D2240/00—Components
- F05D2240/20—Rotors
- F05D2240/30—Characteristics of rotor blades, i.e. of any element transforming dynamic fluid energy to or from rotational energy and being attached to a rotor
- F05D2240/301—Cross-sectional characteristics
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F05—INDEXING SCHEMES RELATING TO ENGINES OR PUMPS IN VARIOUS SUBCLASSES OF CLASSES F01-F04
- F05D—INDEXING SCHEME FOR ASPECTS RELATING TO NON-POSITIVE-DISPLACEMENT MACHINES OR ENGINES, GAS-TURBINES OR JET-PROPULSION PLANTS
- F05D2240/00—Components
- F05D2240/40—Use of a multiplicity of similar components
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F05—INDEXING SCHEMES RELATING TO ENGINES OR PUMPS IN VARIOUS SUBCLASSES OF CLASSES F01-F04
- F05D—INDEXING SCHEME FOR ASPECTS RELATING TO NON-POSITIVE-DISPLACEMENT MACHINES OR ENGINES, GAS-TURBINES OR JET-PROPULSION PLANTS
- F05D2250/00—Geometry
- F05D2250/50—Inlet or outlet
- F05D2250/51—Inlet
Definitions
- This invention pertains in general to the field of systems and methods for collecting a sample from exhaled breath of a subject, and for detecting the presence or determining the quantitative amount of at least one drug substance in said exhaled breath. More particularly the invention relates to such portable systems.
- exhaled breath is commonly used in alcohol testing and today's technology makes it possible to perform on-site breath testing with legally defensible results using infrared spectroscopy.
- Chromatography B, 878 (2010), pages 2255-2259 describe a breath test that provides a non-invasive, not-specimen based apparatus, system and/or method for detecting the presence or determining the quantitative amount of at least one drug substance in a subject.
- an improved apparatus, system and/or method for on-site sampling of a subject for drug substances is desired.
- Such an apparatus, system and/or method for sampling the subject for illicit drugs of abuse and/or medical drugs would be desired.
- the apparatus, system and/or method should be efficient, non-bulky, user friendly both for operators and the subject. It should further be not intruding and not invasive.
- embodiments of the present invention seek to mitigate, alleviate or eliminate one or more deficiencies, disadvantages or issues in the art, such as the above-identified, singly or in any combination by providing a system and a method, according to the appended patent claims.
- a portable system configured to collect a sample from exhaled breath of a subject, and for detecting the presence or determining the quantitative amount of at least one drug substance in said exhaled breath.
- the system is adapted to collect the sample for further analysis using mass-spectroscopy.
- the system comprises a sampling unit and a housing arranged to hold the sampling unit.
- the sampling unit is adapted to collect non-volatile organic compounds of the at least one drug substance from the exhaled breath from the subject.
- the housing comprises at least one inlet for the subject to exhale into the housing to the sampling unit and at least one outlet for the exhaled breath to exit through.
- the exhaled breath volume is not stored in a volume for analysis of the chemical contents of the entire breath volume. Rather, traces of the drug substance are attached to a collecting element and then further analyzed from this element. Analysis is not made online of the breath volume, but of the traces in the collecting element.
- the collecting element may be removable from a housing and sent further for the analysis. Collection of the traces is made quick, a single exhalation may be sufficient. Less than 10 subsequent exhalations are more than sufficient to obtain reliable results and improve robustness of the system. This is far more convenient and quicker than any previous breath sample collection methods.
- Non-volatile compounds are transferred from the lungs, possibly carried by an aerosol.
- the non-volatile compounds are drug substances and could be either medical drugs or legal or illegal narcotic substances.
- the drug substances are collected on-site using a portable system comprising a sampling unit.
- the collected samples could be sent to a laboratory for further analysis.
- compact on-site analysis may be performed.
- the analysis is performed using a suitable analyzing method like spectroscopy or preferably mass-spectroscopy.
- the sampling unit could either be a suitable element for collecting the non-volatile compounds or be a sampling unit comprising an element that is suitable to collect both non-volatile compounds.
- the system Since the system is small and designed to be easy to handle it can be used by any personnel on-site. Thus the system is adapted to be used instead of more intrusive tests like tests based on the much common urine or blood samples.
- the housing could be made of any material like, plastic, metal or glass as long as it is possibly to clean or make the housing aseptic.
- the housing could alternatively or in addition be made of a disposable material. In this way the housing may, after being used for sampling, and for some embodiments also as part of the analyze step, be discarded.
- the portable sampling system of the invention comprises a detachable mouthpiece element connectable to the inlet and being in communication with said housing element.
- the detachable mouthpiece could be either a mouthpiece similar to the mouthpieces used by alcoholic test or a mask or any other type of mouthpieces suitable for exhaling through.
- the mouthpiece could be fitted with valves or flow sensors.
- the valve could be used to separate inspired fro expired air and also serve as a saliva trap.
- the mouthpiece could be used either for making the inhalation into the portable system easier or for sanitation when the system is not a disposable system and therefore needs to be cleaned between use.
- the portable system could comprise a pump arranged downstream the sampling unit.
- the pump could be placed after the housing element and before or after at least one outlet.
- the pump is arranged for helping the subject to pass the exhaled breath through the portable system.
- This breathing assistance could benefit and help test subjects that have a low or reduced breathing capacity.
- the portable system has a pressure drop through the system not higher than 2 cm water.
- the pressure drop through the system has to be as low as possible. 2 cm water is what a person diagnosed with Chronic obstructive pulmonary disease (COPD) can breath through.
- COPD Chronic obstructive pulmonary disease
- the sampling unit comprises at least one filter membrane comprising two layers wherein the first layer is a gas permeable layer and the second layer is adapted to collect non-volatile compounds from the exhaled breath of the subject.
- Such layers are known in the field of respiratory filters, see e.g. US5195527 and US6209541 .
- the filter membrane has preferably a mesh size to collect particles from the exhaled breath with a size of 0,2 - 0,7 ⁇ m. And even more preferably is the filter membrane chosen such that a pressure drop of less than 2 cm water occurs between said inlet and outlet at an exhalation flow rate of over 0 and up to 9 liters per second.
- the flow rate of a subject's exhalation depends on some parameters for example the subject's age, mental state (MR, Alzheimer's), medical condition (sepsis, Parkinson's) or other medications like benzodiazepines, opiates, neuroleptics, local anesthetics or intoxicants etc.
- the filter membrane could, after the subject has exhaled through the system, easily be removed and sent to a laboratory to be analyzed. The portable system could then be cleaned and a new filter could be put in place.
- the collected particles from the filter are analyzable by mass-spectroscopy.
- the mass-spectroscopy is the preferred method, also for other embodiments than those comprising a filter in the sampling unit, since the technology has a very high selectivity and sensibility of bioanalysis especially with regards to trace analytes in biological samples.
- the preferable interface is liquid chromatography.
- the filter membrane an electrostatic filter membrane.
- An electrostatic filter is here defined as a filter that has an electrostatic charge that has a polarity opposite the particles that should be collected from the exhaled breath.
- the filter could be made highly selective to certain drug substances.
- the filters emptied from collected particles and analyzed by dissolving the collected particles from the exhaled breath in a solvent and placing the solution on a Surface Enhanced Raman Spectroscopy (SERS)- substrate to be analyzed using Raman spectroscopy.
- SERS Surface Enhanced Raman Spectroscopy
- the analysis could also be performed using a SERS-senor such as a SERS-probe.
- the at least one filter membrane at least two filter membranes to discriminate at least two different drug substances. This is provided by having filter membranes with different filter selectivity.
- This may be provided by stacking or arranging at least two filters adjacent each other. Each filter may have different mesh types or electrostatic charges.
- the sampling unit could thus discriminate between at least two different drug substances. This could improve the analysis.
- the portable system comprises a compartment for collecting saliva and/or condensate.
- the compartment could be arranged between the at least one inlet and the sampling unit and/or after the sampling unit and the at least one outlet. This may prevent clogging of the sampling unit, e.g. when having hydrophobic filters that may become saturated by condensed humidity or saliva from the exhaled breaths.
- two spaces could be formed: one space between the at least one inlet and the sampling unit and one space between the sampling unit and the at least one outlet.
- a similar compartment capable to collect condensate could be arrange communicating with the space after the sampling unit and the at least on outlet.
- compositions of the exhaled particles are believed to reflect the airway liquid fluid, which probably reflects the blood content of the drug.
- the drug substances are believed by the inventors to most likely to come from the central part of the airway system.
- the non-volatile drug substances are carried as liquid droplets (aerosol) that are formed during normal breathing by the turbulent airflow causing the airway-lining fluid to nebulize.
- the aerosols are possible to collect as exhaled breath condensates.
- the theory comes from Anesthetic studies that have showed that Anesthetic potency correlates with lipid solubility. Holds true across species and implies when a specific hydrophobic region is occupied the more soluble the anesthetic agent is in blood the faster the drug goes into the body.
- the detectable drug substance including in the noncomprehensive list comprising Amphetamines, ecstasy, Cannabis (THC and cannabinoids), Opiates heroin/morphine, 6-AM), Cocaine, Benzodiazepines, Propoxyphene, Methadone, Buprenorphine, Tramadol, LSD, Designer/Internet drugs, Kathinon, GHB, Meprobamat, Z-drugs, Tryptamines, Anabolic steroids, Alcohol/markers but are not limited to these since other illicit drugs not included in the list could should also be detectable due to similar interchanges with the human body as the above mentioned illicit drug substances.
- a method for portably collecting a sample from exhaled breath of a subject, and for detecting the presence or determining the quantitative amount of at least one drug substance in the exhaled breath.
- the method comprises collecting the sample using a system, according to the aforementioned aspect of the invention, from the subject; and analyzing the collected non-volatile compounds of the at least one drug substance using mass-spectroscopy.
- the collecting comprises collecting non-volatile compounds of the at least one drug substance from the exhaled breath from the subject in a sampling unit held in a housing of the system.
- the collecting comprising the subject exhaling into at least one inlet of the housing to the sampling unit and further to at least one outlet to exit from the housing.
- the method comprises discriminating between at least two different drug substances by means of at least two sampling elements.
- the sampling element is defined as an element for suitably collecting the drug substances. This could either be the sampling unit itself or a collecting element, such as a filter or fiber probe tip, arranged in the sampling unit.
- the method comprises collecting the at least one drug substance using at least one filter membrane arranged in the sampling unit.
- a portable sampling system 10 is shown.
- the system comprises a housing 12 for holding the sampling unit 14.
- the housing 12 could either be one sole element or be constructed out of two or more parts.
- the housing could be made of any material or combinations thereof such as, metal, plastic, glass or ceramics.
- the housing 12 comprises at least one inlet 15 that is designed to allow a subject to exhale in.
- the inlet is in one embodiment dimensioned to fit an optional mouth piece 11 preferably of the same size or type as a conventional mouth piece used for alcohol-test.
- the mouth piece 11 prevents contamination between subjects to sample.
- the exhaled breath will then enter a first chamber of the housing that is designed to spread or focus the exhaled breath over or onto the sampling unit 14.
- the exhaled gas is thus conveyed in the housing 12 to the sampling unit 14 and brought into contact with the sampling unit 14.
- the sampling unit comprises an arrangement that holds an element 13 for collecting at least one drug substance being non-volatile compounds from the volume of exhaled breath conveyed in the flow in the housing 12. It should be noted that the sampling unit 14 is not to be confused with an electronic sampling unit.
- the collecting element 13 is a physical entity on which the drug substance is collected. Collection may in different embodiments be based on various principles, singly or in combination, comprising depositing, catching, fastening, condensing of non-volatile constituents on the collecting element 13.
- the element for collecting 13 the at least one drug substance is a filter membrane.
- the at least one drug substance may comprise one or more drug compounds.
- the outlet 16 is, in one embodiment of the invention, the whole back of the housing 12, which is the opening of the outlet 16.
- the filter is in this embodiment for instance attached to the housing 12 with retaining elements, such as clips.
- the filter may also be attached to the housing 12 by means of a second housing element, which may be a ring formed element that is either screwed or slid onto the first housing element retaining the filter.
- the filter itself will then form the back outlet opening 16 of the housing 12 while it is removable kept in the housing 12 by the retainer means.
- the second housing element that is either screwed or slid onto the first housing element, comprises one central outlet 16.
- many outlets 16 are arranged over the surface of the second outlet 16 in such a manner that the pressure drop is as low as possible when exhaling breath through the system 10.
- the sampling unit 14 comprising the element suitably for collecting the drug substances 13 is hold in place by or made of spacer pieces attached to the walls of the housing 12 and either the sampling unit 14 or direct onto the element suitably for collecting the drug substances 13.
- the sampling unit 14 is arranged such that there is an air passage around it so that the air can still flow through the sampling unit 14 even if the comprised filter (collecting element 13) became saturated causing an undesired high pressure drop.
- This kind of sampling unit 14 arrangement thus further improves the exhaled breath spreading inside the housing 12, whereby the surface of the sampling unit 12 is used more optimal.
- the system 10 comprises a pump 17, arranged downstream the sampling unit 14, after the housing 12 and before or after at least one outlet 16 of the housing 12.
- the pump 17 is adapted to assists the subject to pass the exhaled breath through said system 10.
- the pump 17 generates a negative pressure over the sampling unit 14. For example if the subject has reduced lung capacity due to drug abuse or illness, this is advantageous.
- the sampling is assisted by the flow through the sampling unit 14 generated by the pump 17.
- a flow sensor is arranged downstream the inlet 15 or at the mouthpiece, for measuring an exhaled volume or flow of exhaled breath.
- the sensor may be a differential pressure sensor for measuring the differential pressure across the sampling unit 14.
- the output from the differential pressure sensor is in non-turbulent flow linear to the flow through the sampling unit 14 which is used to calculate the volume of exhaled breath having passed the sampling unit 14. This could then be used for calculation of the concentration of drug substances in the exhaled breath.
- the volume data are used for determining if sufficient volume has reached the sampling unit 14 for reliably determining the presence or the quantitative amount of a drug substance in the exhaled breath.
- Some embodiments of the system 10 comprises at least one compartment for collecting saliva and/or condensate.
- the compartment could be arranged either between said at least one inlet 15 and said sampling unit 14 and/or after said sampling unit 14 and said at least one outlet 16. This would allow for saliva comprised in the exhaled breath or condensate formed, from the moist in the exhaled breath, on the sampling unit 14 to be collected and not affect the sampling unit 14 and the comprised collecting element 13 in any negative way. Negative ways could here be a wet or clogged sampling element 13 that collects the drug substances i.e. the filter membrane.
- Fig. 2a is an embodiment showing a housing 12 with a outlet 16 and an mouthpiece 11 in flow communication with an inlet.
- the outlet 16 covers the main portion of the back of the housing 12.
- the sampling unit 14 comprising a collecting element 13, being a filter membrane, be seen through the outlet 16.
- Fig 2c shows the main parts of this embodiment of the portable system 10; a first housing part 12a; a second housing part 12b; a sampling unit 14 comprising a filter membrane.
- the housing 12 is made of two parts the first part 12a comprises an inlet 15 that can be in flow communication with a mouthpiece 11 and a second part 12b with one large outlet 16.
- Fig. 2d is an alternative or additional embodiment showing a housing 12 comprising a sampling unit being a filter membrane.
- This embodiment comprises two parts that when attached forms a housing 12 that holds a filter membrane.
- the housing comprises an inlet 15 suitable for a mouthpiece 11 and an outlet 16.
- This embodiment is very small, light weighted and easy to carry.
- the collecting element 13 is in form of a filter
- the filter comprises a filtering membrane for the exhaled breath to diffuse through.
- the filter membrane is made of a suitable absorbing, yet gas permeable, material.
- the filter membrane will have a structure that catches and collects the drug substances being, exhaled particles, non-volatile compounds while letting gas pass through.
- the filter membrane is operable to sample or remove chemical compounds (drug substances) from the air with a high volumetric capacity while maintaining a low pressure drop across the filter substrate.
- the filter membrane could also be an electrostatic filter in some embodiments.
- the filter membrane may be of a nonwoven polymeric fibrous web that is transformed into an electret.
- the electret is a dielectric material exhibiting a quasi permanent electric charge.
- Electret filters usually loose their charge upon long-term use. However, in the present application, the filter will not be used extensive times. A single exhalation may be sufficient to collect sufficient traces for a reliable analysis. Therefore, loss of electric charge will not be a concern in implementations of electret filter embodiments.
- the filter membrane is a layered filter membrane. How the collecting of the analytes work is not entirely investigated. However, applicants believe that the first layer collects droplets by absorption or particles from exhaled breath. In addition, or alternatively, it could also be from exhaled breath absorbing or condensates and the small amount of water then evaporates, thus leaving thousands of analytes from the exhaled breath on the first surface. In addition, or alternatively, the analytes may be part of an aerosol conveyed by the exhaled breath, which aerosol particles stick to the first layer. Evaporation may also take place of aerosol, which then leaves the traces of the analytes on the first layer for analysis.
- the first layer is gas permeable thus the analytes not collected on the first layer will pass through entering the second layer being a fiber like filter made of a synthetic, natural or half synthetic material.
- the second layer has a fiber density creating a surface volume. The gat will pass through the second layer that will collect the analytes by similar mechanism as described above but it could also be due to charges of the fibers that will make the analytes stick to the surface of the fibers.
- the filter material comprises glass fibers.
- the glass fibers may be bearing a permanent electrostatic charge to improve the efficiency of the filter in the current application.
- the glass fibers may be randomly oriented.
- the glass fibers may be held in place by suitable outer layers of a different material.
- the glass fibers may also be partly melt together to provide a solid filter cartridge. A highly efficient filter for collecting traces of chemical compounds from exhaled breath may thus be provided while maintaining a low pressure drop at high exhalation rates, as desired.
- Fig. 4 is a graph 40 that shows the pressure drop in mm water Y as a function of the gas-flow X in the unit liter per minute and wherein the diameter of the filter is a parameter.
- the diameters of the filters tested are 10 mm (curve 41), 13 mm (curve 42), 16 mm (curve 43), 19 mm (curve 44) and 22 mm (curve 45).
- a small filter volume to extract from is preferred. This could be done, for this particular filter membrane, by making the diameter smaller. But at the same time the volume exhaled though the filter membrane should not generate a high drop of pressure.
- the filter membrane should collect drug substances from a, as large volume of one deeply exhaled breath, as possible and at the same time not generate a high pressure drop.
- a healthy person should be able to handle a pressure drop of about 20 mm of water.
- a filter size, for this particular filter membrane, of about 16 mm should be possible to use and still have an acceptable pressure drop.
- the sensitivity of the used LC/MS method and this particular filter membrane makes it possible to detect drug substances from one exhaled breath.
- the results indicates that short collecting times are possible and even shorter collecting times should be performable using this particular filter membrane since the sensitivity of the LC-MS method allows for detections of lower amounts than the measured.
- the measured amount of drug substance could also be obtained by a small filter volume to extract from. This according to what previously have been described.
- Fig. 5 is a schematic illustration illustrating an embodiment of a portable system 50 configured to collect a sample from exhaled breath of a subject 51.
- the subject will exhale through the mouthpiece 52 being in flow communication with a housing 54 via at least one inlet 53.
- the housing comprises a sampling unit 55 that is either a collecting element or comprises a collecting element for collecting the drug substances from the exhaled breath.
- the exhaled breath exits the housing through at least one outlet 56.
- the sampling unit 55 and/or collecting element is sent to a laboratory 57 to be analyzed.
- the housing 54 could be the sampling unit 55.
- the sampling unit 55 could comprise more than one collecting element, and/or the housing 54 could comprise more than one sampling unit, in any combination, suitably for collecting drug substances This will make it possible to discriminate between different drug substances, thus making the analysis easier to perform.
- the sampling unit 55 comprises at least one filter membrane, but it could include a stack of filter membranes with different physical and/or chemical properties. But multiple filter could also be used by using sampling unit 55 comprising areas fitted with different filter membranes.
- sampling system and elements for collecting drug substances should be kept clean and preferable be aseptic but do not need to be sterile.
- Fig. 6 is a flow-chart illustrating a method 60 for using a portable system configured to collecting a sample 62 of exhaled breath and for detecting the presence or determining the quantitative amount 63 of at least one drug substance in the collected sample.
- the method comprises the steps of: A subject exhaling 61 into the invented portable system; a sampling unit will collect a sample 62 comprises drug substances; the collected sample will be analyzed using mass-spectroscopy 63.
- Chromatograms 70 are shown from the identification of amphetamine (A) and methamphetamine (B) in exhaled breath from one subject after intake of "amphetamine".
- Y are here representing response (CPS) and X time (min).
- the conventionally analyzed urine and plasma data of the same subject taken for comparison reasons suggest possible intake of methamphetamine with amphetamine.
- Identification using a sampling unit and LC-MS-MS analysis was based on the presence of compounds with correct retention time and with correct relative abundance of two product ions.
- the identification of detected analytes was based on a correct relative (to amphetamine-d 5 ) retention time.
- a subject will exhale 61 in and out either for a certain time or for a fixed number of times such as 1 to 10 times into a portable system.
- each exhale could be set to last for a fixed time.
- the exhalation could also be performed until a certain volume of exhaled breath has been obtained.
- a deep breath is preferred to reach exhaled breath from deep lying lung portions such as the central or the peripheral lung regions.
- the exhaled breath will then be collected 62 by the sampling unit comprising at least one element suitably for collecting drug substances before it exits the system.
- the sampling unit will then be removed so that the at least one element suitably for collecting drug substances can be analyzed 63 using an appropriate mass-spectroscopy method.
- the whole housing could be sent to be analyzed.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Medical Informatics (AREA)
- Public Health (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physiology (AREA)
- Pulmonology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Claims (15)
- Tragbares Probeentnahmesystem, das zum Entnehmen einer zu analysierenden Probe aus der Ausatemluft einer Testperson eingerichtet ist, wobei das System umfasst:eine Probeentnahme-Einheit (14) und Gehäuse (12), das so angeordnet ist, dass es die Probeentnahme-Einheit (14) hält,wobei die Probeentnahme-Einheit (14) mindestens eine Filtermembran (13) umfasst, welche zwei Schichten aufweist, wobei es sich bei einer ersten Schicht um eine gasdurchlässige Schicht und es sich bei einer zweiten Schicht um eine faserartige Schicht handelt, die so angepasst ist, dass sie nichtflüchtige Drogenverbindungen aus der Ausatemluft der Testperson erfasst; unddas Gehäuse (12) mindestens einen Einlass (15) umfasst, der so angepasst ist, dass die Testperson in das Gehäuse hinein ausatmen kann, und mindestens einen Auslass (16) umfasst, damit die Ausatemluft aus dem Gehäuse entweichen kann;ein abnehmbares Mundstückelement, das sich mit dem Einlass verbinden lässt; undgekennzeichnet durch einen Durchflusssensor, der so eingerichtet ist, dass er bestimmen kann, wann ein ausreichendes Volumen von Ausatemluft die Filtermembran passiert hat, wobei der Durchflusssensor an dem Mundstück oder stromabwärts des Einlasses angeordnet ist.
- System gemäß Anspruch 1, wobei ein Druckabfall durch das System weniger als 2 cm Wasser beträgt.
- System gemäß einem beliebigen der Ansprüche 1 bis 2, eine Pumpe umfassend, wobei die Pumpe stromab der Filtermembran angeordnet ist.
- System gemäß einem beliebigen der Ansprüche 1 bis 3, wobei die Filtermembran eine Maschengröße zum Erfassen von Partikeln aus der Ausatemluft mit einer Größe von 0,2 bis 0,7 µm aufweist; und/oder wobei die Filtermembran aus einem synthetischen oder natürlichen oder halbsynthetischen Material hergestellt ist; und/oder wobei es sich bei der Filtermembran um einen polymeren Vliesfaserflor handelt; und/oder wobei die zweite Schicht elektrostatisch ist.
- System gemäß einem beliebigen der Ansprüche 1 bis 4, wobei die Filtermembran so ausgewählt ist, dass es bei einer Ausatmungs-Durchflussrate von ungefähr 0 bis 9 l/min zwischen dem Einlass und dem Auslass zu einem Druckabfall von weniger als 2 cm Wasser kommt.
- System gemäß einem beliebigen der Ansprüche 1 bis 5, wobei die im Filter erfassten Partikel mittels Massenspektroskopie analysiert werden können.
- System gemäß einem beliebigen der Ansprüche 1 bis 6, wobei die Probeentnahme-Einheit mindestens zwei Filtermembranen [aufweist], die so eingerichtet sind, dass sie mindestens zwei verschiedene nichtflüchtige Verbindungen unterscheiden können.
- System gemäß einem beliebigen der Ansprüche 1 bis 7, wobei eine Kammer zur Entnahme von Speichel und/oder Kondensat zwischen dem mindestens einen Einlass und der Probeentnahme-Einheit und/oder nach der Probeentnahme-Einheit und dem mindestens einen Auslass angeordnet ist.
- System gemäß einem beliebigen der Ansprüche 1 bis 8, wobei es sich bei den nichtflüchtigen Verbindungen um mindestens eine Drogensubstanz in der Ausatemluft handelt, wobei dies Verbindungen sind, die über die Lungenmembran aus dem Blut der Testperson übertragen werden können; und/oder wobei es sich bei der nichtflüchtigen Verbindung um mindestens eine Drogensubstanz in der Ausatemluft handelt, die in der Liste enthalten ist, welche Amphetamine, Ecstasy, Cannabis, THC und Cannabinoide, Opiate, Heroin, Morphin, 6-AM, Kokain, Benzodiazepine, Propoxyphen, Methadon, Buprenorphin, Tramadol, LSD, Designer/Internet-Drogen, Cathinon, GHB, Meprobamat, Z-Drogen, Tryptamine oder anabole Steroide umfasst.
- Verfahren zur tragbaren Entnahme einer Probe aus der Ausatemluft einer Testperson und zum Feststellen des Vorhandenseins oder zur Bestimmung der quantitativen Menge mindestens einer Drogensubstanz, wobei das Verfahren die folgenden Schritte umfasst:Entnahme (62) einer Probe aus der Ausatmung (61) der Testperson mittels eines tragbaren Systems gemäß einem beliebigen der vorhergehenden Ansprüche; undAnalyse der entnommenen nichtflüchtigen Verbindungen der mindestens einen Drogensubstanz unter Verwendung von Massenspektroskopie.
- Verfahren gemäß Anspruch 10, wobei die Entnahme das Ausatmen der Testperson in mindestens einen Einlass des Gehäuses zu der Filtermembran und weiter zu mindestens einem Auslass hin umfasst, so dass ein Entweichen aus dem Gehäuse erfolgt; und/oder das Verfahren die Erzeugung eines Sogs mittels einer Pumpe umfasst, die stromab der Filtermembran angeordnet ist; und/oder wobei der Sog die Testperson dabei unterstützt, die Ausatemluft durch die Filtermembran hindurch zu schicken.
- Verfahren gemäß einem beliebigen der Ansprüche 10 bis 11, wobei ein Fluss der Ausatemluft einen Druckabfall von nicht mehr als 2 cm Wasser über die Probeentnahme-Einheit hinweg erzeugt; und/oder wobei die Filtermembran eine Maschengröße zum Erfassen von Partikeln aus der Ausatemluft mit einer Größe von 0,2 bis 0,7 µm aufweist; und/oder wobei die Filtermembran aus einem synthetischen oder natürlichen oder halbsynthetischem Material hergestellt ist; und/oder wobei es sich bei der Filtermembran um einen polymeren Vliesfaserflor handelt; und/oder wobei die zweite Schicht der zweischichtigen Filtermembran elektrostatisch ist.
- Verfahren gemäß einem beliebigen der Ansprüche 10 bis 12, die Entnahme von Speichel und/oder Kondensat aus der Ausatemluft unter Verwendung einer Kammer umfassend, die zwischen dem mindestens einen Einlass und der Filtermembran angeordnet ist; und/oder die Unterscheidung zwischen mindestens zwei verschiedenen nichtflüchtigen Verbindungen mittels mindestens zweier Filtermembranen umfassend.
- Verfahren gemäß einem beliebigen der Ansprüche 10 bis 13, wobei es sich bei den nichtflüchtigen Verbindungen um mindestens eine Drogensubstanz in der Ausatemluft handelt, wobei dies Verbindungen sind, die über die Lungenmembran aus dem Blut der Testperson übertragen werden können; und/oder wobei es sich bei den nichtflüchtigen Verbindungen um mindestens eine Drogensubstanz in der Ausatemluft handelt, wobei diese in der Liste enthalten ist, welche Amphetamine, Ecstasy, Cannabis, THC und Cannabinoide, Opiate, Heroin, Morphin, 6-AM, Kokain, Benzodiazepine, Propoxyphen, Methadon, Buprenorphin, Tramadol, LSD, Designer/Internet-Drogen, Cathinon, GHB, Meprobamat, Z-Drogen, Tryptamine, oder anabole Steroide umfasst.
- Verwendung eines Systems gemäß einem beliebigen der Ansprüche 1 bis 9 oder eines Verfahrens gemäß Ansprüchen 10 bis 14 zur nicht-intrusiven Atemkontrolle auf Drogensubstanzen bei einer Testperson; oder als ein Ersatz für das Testen der Testperson auf die Drogensubstanz anstelle des Testens von Blut oder Urin.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17201359.1A EP3336543A1 (de) | 2009-09-09 | 2010-09-09 | Drogendetektion in ausgeatmeter luft |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24075209P | 2009-09-09 | 2009-09-09 | |
EP10751947.2A EP2361387B1 (de) | 2009-09-09 | 2010-09-09 | Nachweis von drogen in ausgeatmeter luft |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10751947.2A Division EP2361387B1 (de) | 2009-09-09 | 2010-09-09 | Nachweis von drogen in ausgeatmeter luft |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP17201359.1A Division EP3336543A1 (de) | 2009-09-09 | 2010-09-09 | Drogendetektion in ausgeatmeter luft |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2765420A1 EP2765420A1 (de) | 2014-08-13 |
EP2765420B1 true EP2765420B1 (de) | 2017-11-15 |
Family
ID=43037755
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP14164315.5A Withdrawn EP2765421A1 (de) | 2009-09-09 | 2010-09-09 | Nachweis von Drogen in ausgeatmeter Luft |
EP14164314.8A Active EP2765420B1 (de) | 2009-09-09 | 2010-09-09 | Nachweis von Drogen in ausgeatmeter Luft |
EP10751947.2A Active EP2361387B1 (de) | 2009-09-09 | 2010-09-09 | Nachweis von drogen in ausgeatmeter luft |
EP10754461.1A Not-in-force EP2475977B1 (de) | 2009-09-09 | 2010-09-09 | Oberflächenverstärkte raman-streuung zur drogendetektion in ausgeatmeter luft |
EP17201359.1A Withdrawn EP3336543A1 (de) | 2009-09-09 | 2010-09-09 | Drogendetektion in ausgeatmeter luft |
EP15170749.4A Withdrawn EP2982980A1 (de) | 2009-09-09 | 2010-09-09 | Oberflächenverstärkte raman-streuung zur drogendetektion in ausgeatmeter luft |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP14164315.5A Withdrawn EP2765421A1 (de) | 2009-09-09 | 2010-09-09 | Nachweis von Drogen in ausgeatmeter Luft |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10751947.2A Active EP2361387B1 (de) | 2009-09-09 | 2010-09-09 | Nachweis von drogen in ausgeatmeter luft |
EP10754461.1A Not-in-force EP2475977B1 (de) | 2009-09-09 | 2010-09-09 | Oberflächenverstärkte raman-streuung zur drogendetektion in ausgeatmeter luft |
EP17201359.1A Withdrawn EP3336543A1 (de) | 2009-09-09 | 2010-09-09 | Drogendetektion in ausgeatmeter luft |
EP15170749.4A Withdrawn EP2982980A1 (de) | 2009-09-09 | 2010-09-09 | Oberflächenverstärkte raman-streuung zur drogendetektion in ausgeatmeter luft |
Country Status (16)
Country | Link |
---|---|
US (6) | US8368883B2 (de) |
EP (6) | EP2765421A1 (de) |
JP (2) | JP5992328B2 (de) |
CN (1) | CN102498398B (de) |
AU (1) | AU2010294183B2 (de) |
BR (1) | BR112012005198A8 (de) |
CA (2) | CA3029712A1 (de) |
DK (1) | DK2765420T3 (de) |
EA (1) | EA023922B1 (de) |
ES (2) | ES2659738T3 (de) |
HU (1) | HUE038136T2 (de) |
MX (1) | MX2012002976A (de) |
NO (1) | NO2765420T3 (de) |
TR (1) | TR201802101T4 (de) |
WO (2) | WO2011029889A1 (de) |
ZA (1) | ZA201201304B (de) |
Families Citing this family (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110178420A1 (en) * | 2010-01-18 | 2011-07-21 | Trent Ridder | Methods and apparatuses for improving breath alcohol testing |
CA3029712A1 (en) | 2009-09-09 | 2011-03-17 | Sensa Bues Ab | Drug detection in exhaled breath |
US9417232B2 (en) * | 2009-10-02 | 2016-08-16 | Bi Mobile Breath, Inc. | Sobriety monitoring system |
US9228997B2 (en) | 2009-10-02 | 2016-01-05 | Soberlink, Inc. | Sobriety monitoring system |
US8707758B2 (en) | 2009-10-02 | 2014-04-29 | Soberlink, Inc. | Sobriety monitoring system |
WO2012006250A1 (en) | 2010-07-06 | 2012-01-12 | Deton Corp. | System for airborne bacterial sample collection and analysis |
US8814804B2 (en) * | 2010-12-13 | 2014-08-26 | Iph, Llc | Interactive blood-alcohol content tester |
EP2518499B1 (de) * | 2011-03-09 | 2015-06-10 | Sensa Bues AB | Tragbare Probenahmevorrichtung und Verfahren für den Nachweis von Drogen in der Ausatemluft |
EP2498091A1 (de) * | 2011-03-09 | 2012-09-12 | Sensa Bues AB | Fahrzeugverriegelungssystem und Verfahren basierend auf dem Nachweis von Analyten in der Ausatemluft |
US20120327407A1 (en) * | 2011-06-21 | 2012-12-27 | University Of Georgia Research Foundation, Inc. | Independent Component Analysis of Surface-Enhanced Raman Scattering (SERS) Signals |
BR112013033418A2 (pt) * | 2011-07-01 | 2017-01-24 | 3M Innovative Properties Co | método e aparelho para testar infratores no uso de drogas |
US9255842B2 (en) | 2011-07-13 | 2016-02-09 | Thermo Scientific Portable Analytical Instruments Inc. | Heroin detection by raman spectroscopy from impure compositions comprising an interfering fluorescent contaminant |
US9689864B2 (en) | 2012-02-01 | 2017-06-27 | Invoy Technologies, Llc | Method and apparatus for rapid quantification of an analyte in breath |
US20140276100A1 (en) * | 2012-02-01 | 2014-09-18 | Invoy Technologies | System for measuring breath analytes |
US9636044B2 (en) | 2012-02-01 | 2017-05-02 | Invoy Technologies, Llc | Breath analyzer with expandable range of measurement |
EP2823300B1 (de) | 2012-03-08 | 2019-10-09 | Sensa Bues AB | Verfahren zum nachweis von biomarkern in atemluft |
WO2013174387A1 (en) | 2012-05-23 | 2013-11-28 | Danmarks Tekniske Universitet | A system for obtaining an optical spectrum |
US9617582B2 (en) | 2012-09-04 | 2017-04-11 | University Of Maryland College Park | Human exhaled aerosol droplet biomarker system and method |
EP2706355A1 (de) * | 2012-09-11 | 2014-03-12 | Sensa Bues AB | System und Verfahren zur Eluierung und Prüfung einer Substanz aus einer ausgeatmeten Aerosolprobe |
US10080857B2 (en) | 2013-03-12 | 2018-09-25 | Deton Corp. | System for breath sample collection and analysis |
CN103163268A (zh) * | 2013-03-21 | 2013-06-19 | 北京华新安科科技有限公司 | 一种医用呼气检测装置及其检测方法 |
WO2014184604A1 (en) * | 2013-05-16 | 2014-11-20 | L'oreal | Installation and method for determining the diffusion profile of at least one molecule through skin |
US9665689B2 (en) | 2013-05-17 | 2017-05-30 | Viavi Solutions Inc. | Medication assurance system and method |
CN103487481B (zh) * | 2013-10-16 | 2016-01-13 | 无锡市尚沃医疗电子股份有限公司 | 一种呼气氨气分析仪 |
US9970950B1 (en) | 2014-03-09 | 2018-05-15 | Hound Labs, Inc. | Method and apparatus for detecting acute use of target substance(s) |
JP6311387B2 (ja) * | 2014-03-26 | 2018-04-18 | 株式会社島津製作所 | 化合物分析方法、化合物分析装置、及び化合物分析用プログラム |
CA2850998A1 (en) | 2014-04-18 | 2015-10-18 | Thc Breathalyzer, Inc. | Cannabis drug detection device |
HUE044429T2 (hu) | 2014-06-27 | 2019-10-28 | Pulse Health Llc | Analizáló patron és eljárás annak használatára |
CN106796217A (zh) * | 2014-07-21 | 2017-05-31 | 泰克年研究发展基金会公司 | 用于直接呼吸采样的组合物 |
EP3164693A4 (de) * | 2014-08-27 | 2018-07-25 | Lifeloc Technologies, Inc. | Arzneimittelerkennung durch spektrale signatur |
KR101711425B1 (ko) * | 2014-12-19 | 2017-03-02 | 대전대학교 산학협력단 | 미세입자 포집장치 및 이를 이용하여 미세입자를 분석하는 방법 |
US9726684B1 (en) | 2015-01-18 | 2017-08-08 | Hound Labs, Inc. | Compositions for target substance detection and measurement |
CN104655829A (zh) * | 2015-03-06 | 2015-05-27 | 张波 | 一种口腔护理指示系统 |
US9733225B2 (en) * | 2015-03-07 | 2017-08-15 | Matthew David Armstrong | Spectroscopic breath detector |
WO2016166623A1 (en) * | 2015-04-17 | 2016-10-20 | Cannabix Technologies Inc. | Cannabis drug detection device |
CN104914089B (zh) * | 2015-06-18 | 2017-10-27 | 清华大学 | 用表面增强拉曼光谱对痕量混合物进行半定量分析的方法 |
US11726102B2 (en) * | 2015-07-24 | 2023-08-15 | Washington State University | Particle-based drug detection method and device embodiments |
US9922508B2 (en) | 2015-10-09 | 2018-03-20 | Soberlink Healthcare, Llc | Bioresistive-fingerprint based sobriety monitoring system |
CN105510415B (zh) * | 2016-01-04 | 2017-12-29 | 广西民族大学 | 一种高灵敏度的官能化金纳米粒子掺杂的甲丙氨酯分子印迹电化学传感器的制备方法 |
US10557844B2 (en) | 2016-04-08 | 2020-02-11 | Soberlink Healthcare, Llc | Bioresistive-fingerprint based sobriety monitoring system |
US10502665B2 (en) | 2016-04-18 | 2019-12-10 | University Of Maryland, College Park | Aerosol collection system and method |
CN109310368A (zh) * | 2016-04-25 | 2019-02-05 | 奥斯通医疗有限公司 | 用于捕获呼吸样本的系统和设备 |
AU2017263715B2 (en) * | 2016-05-13 | 2022-01-13 | Alcolizer Pty Ltd | A mind-altering substance testing system |
US9933445B1 (en) | 2016-05-16 | 2018-04-03 | Hound Labs, Inc. | System and method for target substance identification |
US9921234B1 (en) * | 2016-06-17 | 2018-03-20 | Hound Labs, Inc. | Compositions and methods for detection of target constituent in exhaled breath |
CN106770811A (zh) * | 2016-11-10 | 2017-05-31 | 中国科学院声学研究所 | 一种检测呼气中毒品含量的方法和装置 |
GB201704367D0 (en) * | 2017-03-20 | 2017-05-03 | Exhalation Tech Ltd | A breath condensate analyser |
US11712200B2 (en) * | 2017-04-28 | 2023-08-01 | University of Pittsburgh—of the Commonwealth System of Higher Education | Nanostructure-based cannabinoid sensor |
US11026596B1 (en) | 2017-05-19 | 2021-06-08 | Hound Labs, Inc. | Detection and measurement of target substance in exhaled breath |
US11624703B2 (en) | 2017-08-02 | 2023-04-11 | Vox Biomedical Llc | Virus sensing in exhaled breath by infrared spectroscopy |
US10969333B2 (en) | 2017-08-02 | 2021-04-06 | Vox Biomedical Llc | Sensing cannabis and opioids in exhaled breath by infrared spectroscopy |
US11187711B1 (en) | 2017-09-11 | 2021-11-30 | Hound Labs, Inc. | Analyte detection from breath samples |
TWI663400B (zh) | 2017-09-28 | 2019-06-21 | 國立臺灣大學 | 檢測試紙及檢測毒品的方法 |
AU201815511S (en) | 2018-05-07 | 2018-12-17 | Sensa Bues Ab | Breath sampling device |
US11662340B1 (en) | 2018-07-31 | 2023-05-30 | InspectIR Systems, Inc. | Techniques for rapid detection and quantitation of volatile organic compounds (VOCS) using breath samples |
US11841372B1 (en) | 2018-07-31 | 2023-12-12 | Inspectir Systems, Llc | Techniques for rapid detection and quantitation of volatile organic compounds (VOCs) using breath samples |
US11874270B1 (en) | 2018-07-31 | 2024-01-16 | Inspectir Systems, Llc | Techniques for rapid detection and quantitation of volatile organic compounds (VOCs) using breath samples |
US11721533B1 (en) | 2018-07-31 | 2023-08-08 | Inspectir Systems, Llc | Techniques for rapid detection and quantitation of volatile organic compounds (VOCS) using breath samples |
US11879890B1 (en) | 2018-07-31 | 2024-01-23 | Inspectir Systems, Llc | Techniques for rapid detection and quantitation of volatile organic compounds (VOCS) using breath samples |
CN112533532A (zh) * | 2018-07-31 | 2021-03-19 | 北德克萨斯大学 | 使用呼吸样本快速检测和定量挥发性有机化合物(voc)的技术 |
US11841359B1 (en) | 2018-07-31 | 2023-12-12 | Inspectir Systems, Llc | Techniques for portable rapid detection and quantitation of volatile organic compounds (VOCS) using breath samples |
US11454628B2 (en) * | 2018-08-06 | 2022-09-27 | Northeastern University | On-surface mass tagging |
US11426097B1 (en) | 2018-10-17 | 2022-08-30 | Hound Labs, Inc. | Rotary valve assemblies and methods of use for breath sample cartridge systems |
DE202018106075U1 (de) * | 2018-10-24 | 2020-01-27 | Securetec Detektions-Systeme Ag | Probenanalyseeinrichtung sowie Entnahmeelement für eine Probenanalyseeinrichtung |
US20200245898A1 (en) | 2019-01-31 | 2020-08-06 | Hound Labs, Inc. | Single-use Microfluidic Cartridge for Detection of Target Chemical Presence in Human Breath |
US11977086B2 (en) * | 2019-03-21 | 2024-05-07 | Hound Labs, Inc. | Biomarker detection from breath samples |
IT201900005362A1 (it) * | 2019-04-08 | 2020-10-08 | Centro Regionale Information Communication Tech Cerict Scarl | Ago o catetere provvisto di una pluralita' di fibre ottiche |
WO2021011470A1 (en) | 2019-07-12 | 2021-01-21 | Massachusetts Institute Of Technology | Systems and methods for stochastically modulated raman spectroscopy |
EP4021294A4 (de) | 2019-08-26 | 2023-07-12 | Zeteo Tech, Inc. | Diagnose von tuberkulose und anderen krankheiten mit ausgeatmetem atemzug |
US11839463B2 (en) | 2020-04-03 | 2023-12-12 | Zeteo Tech, Inc. | Diagnosis of respiratory diseases using analysis of exhaled breath and aerosols |
WO2021219749A1 (en) | 2020-04-30 | 2021-11-04 | Vitalograph (Ireland) Ltd. | A sampling device |
US11933731B1 (en) | 2020-05-13 | 2024-03-19 | Hound Labs, Inc. | Systems and methods using Surface-Enhanced Raman Spectroscopy for detecting tetrahydrocannabinol |
EP4171694A4 (de) * | 2020-06-30 | 2024-05-01 | Air-Clenz Systems LLC | Verbesserter sammler für ausgeatmete luft und luftreinigungseinheit und -system |
US20220034761A1 (en) * | 2020-07-29 | 2022-02-03 | Shazi S. Iqbal | Microbial sample collection, transport and processing apparatus and method |
WO2022093876A1 (en) * | 2020-10-26 | 2022-05-05 | Innovaprep Llc | Multi-function face masks |
US11806711B1 (en) | 2021-01-12 | 2023-11-07 | Hound Labs, Inc. | Systems, devices, and methods for fluidic processing of biological or chemical samples using flexible fluidic circuits |
JP2024518022A (ja) * | 2021-03-31 | 2024-04-24 | ゼテオ テック、 インク. | 充填ベッドシステムおよび方法を使用したエアロゾル化生体材料粒子の捕捉による呼吸器疾患の診断 |
WO2022221198A1 (en) * | 2021-04-12 | 2022-10-20 | Proveris Scientific Corporation | Aerosol sample collection device |
RU2768760C1 (ru) * | 2021-07-02 | 2022-03-24 | Василий Алексеевич Елиферов | Способ изготовления картриджей для прямого масс-спектрометрического анализа |
KR102653164B1 (ko) * | 2021-11-16 | 2024-04-01 | 경희대학교 산학협력단 | 암페타민류 마약의 선택적 검출을 위한 조성물, 색변환 센서, 및 이들의 용도 |
SE2250675A1 (en) * | 2022-06-03 | 2023-12-04 | Munkplast Ab | Method and system for preparing a breath sample for analysis |
WO2024081931A1 (en) * | 2022-10-14 | 2024-04-18 | Oreagan Iii Francis J | Breathalyzer test container assembly for storing and releasing gases |
Family Cites Families (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2626642B1 (de) | 1976-06-14 | 1977-12-15 | Werner Prof Dr-Ing Adrian | Vorrichtung zum messen der konzentration von gasen |
US4156143A (en) | 1978-01-10 | 1979-05-22 | Werner Adrian | Device for measuring the concentration of a gas |
US4292978A (en) | 1979-12-26 | 1981-10-06 | Guth Richard U | Breath test mouthpiece |
US4809810A (en) * | 1986-05-01 | 1989-03-07 | Autosense Corporation | Breath alcohol analyzer |
GB8911627D0 (en) * | 1989-05-19 | 1989-07-05 | Intersurgical Guernsey Ltd | Improvements in filters |
US5042501A (en) | 1990-05-01 | 1991-08-27 | Battelle Memorial Institute | Apparatus and method for analysis of expired breath |
US5467776A (en) | 1993-07-28 | 1995-11-21 | The Brewer Company | Air sampling device and method for sampling exhaled air |
US5518002A (en) * | 1993-10-22 | 1996-05-21 | Medtrac Technologies, Inc. | Portable electronic spirometric device |
US5465728A (en) * | 1994-01-11 | 1995-11-14 | Phillips; Michael | Breath collection |
US5478377A (en) * | 1994-07-22 | 1995-12-26 | The United States Of America As Represented By The Secretary Of The Army | Filter for a respiratory device |
EP0997733A3 (de) * | 1995-06-19 | 2004-07-14 | Btg International Limited | Ausatmungsüberwachung für Tiere |
US5814516A (en) * | 1995-10-13 | 1998-09-29 | Lockheed Martin Energy Systems, Inc. | Surface enhanced Raman gene probe and methods thereof |
JPH09243639A (ja) * | 1996-03-06 | 1997-09-19 | Matsushita Electric Ind Co Ltd | 流体吸入式有機物検出装置 |
US5787786A (en) | 1996-05-09 | 1998-08-04 | Sauer-Sundstrand - Control Concepts | Dual hydraulic oscillator for the reciprocating cutter of an agricultural machine |
US5859362A (en) | 1996-10-22 | 1999-01-12 | Revenue Canada | Trace vapor detection |
US5834626A (en) | 1996-11-29 | 1998-11-10 | De Castro; Emory S. | Colorimetric indicators for breath, air, gas and vapor analyses and method of manufacture |
DE19718924A1 (de) * | 1997-04-28 | 1998-10-29 | Medium Sensor Gmbh | Vorrichtung zur Gewinnung von Inhaltsstoffen der Ausatemluft sowie Verfahren zur Isolierung der Inhaltsstoffe und deren Verwendung |
US6097480A (en) | 1998-01-27 | 2000-08-01 | Kaplan; Milton | Vehicle interlock system |
US6209541B1 (en) * | 1998-02-25 | 2001-04-03 | Sims Portex Inc. | Hydrophobic electrostatic breathing filters, and methods of manufacturing the same |
US6432175B1 (en) * | 1998-07-02 | 2002-08-13 | 3M Innovative Properties Company | Fluorinated electret |
US8394330B1 (en) * | 1998-10-02 | 2013-03-12 | The California Institute Of Technology | Conductive organic sensors, arrays and methods of use |
US7057168B2 (en) * | 1999-07-21 | 2006-06-06 | Sionex Corporation | Systems for differential ion mobility analysis |
US6468222B1 (en) * | 1999-08-02 | 2002-10-22 | Healthetech, Inc. | Metabolic calorimeter employing respiratory gas analysis |
US6623977B1 (en) | 1999-11-05 | 2003-09-23 | Real-Time Analyzers, Inc. | Material for surface-enhanced Raman spectroscopy, and SER sensors and method for preparing same |
US20050233459A1 (en) * | 2003-11-26 | 2005-10-20 | Melker Richard J | Marker detection method and apparatus to monitor drug compliance |
EP1409985A4 (de) | 2000-05-01 | 2009-01-07 | Respiratory Res Inc | Verfahren und einrichtung zum abnehmen und analysieren von ausgeatmetem atem |
US6390987B1 (en) * | 2000-08-03 | 2002-05-21 | Ge Marquette Medical Systems, Inc. | Method and apparatus for separating water and gas in a gas analyzer system |
US6553241B2 (en) | 2000-08-31 | 2003-04-22 | Mallinckrodt Inc. | Oximeter sensor with digital memory encoding sensor expiration data |
WO2005098429A2 (en) | 2000-11-08 | 2005-10-20 | University Of Florida Research Foundation, Inc. | System and method for real-time diagnosis, treatment, and therapeutic drug monitoring |
US20050054942A1 (en) * | 2002-01-22 | 2005-03-10 | Melker Richard J. | System and method for therapeutic drug monitoring |
US20070258894A1 (en) * | 2000-11-08 | 2007-11-08 | Melker Richard J | System and Method for Real-Time Diagnosis, Treatment, and Therapeutic Drug Monitoring |
US6623997B2 (en) | 2000-12-15 | 2003-09-23 | Agilent Technologies, Inc. | Method for burn-in processing of optical transmitter arrays using a submount substrate |
AU2002310031A1 (en) * | 2001-05-23 | 2002-12-03 | University Of Florida | Method and apparatus for detecting illicit substances |
EP1392262A1 (de) * | 2001-05-24 | 2004-03-03 | Alexza Molecular Delivery Corporation | Verabreichung von arzneimittel-estern durch inhalation |
WO2002095398A1 (en) * | 2001-05-24 | 2002-11-28 | University Of Florida | Method and apparatus for detecting environmental smoke exposure |
US6547450B2 (en) * | 2001-06-27 | 2003-04-15 | Fitel Usa Corp. | Quick-release dust cap for an optical plug |
US20030023182A1 (en) | 2001-07-26 | 2003-01-30 | Mault James R. | Respiratory connector for respiratory gas analysis |
EP1523551A4 (de) * | 2001-11-09 | 2007-10-31 | Rosestreet Labs Llc | System auf enzymbasis und sensor zur messung von aceton |
WO2003057521A1 (en) | 2001-12-21 | 2003-07-17 | Crespo Pierre M | Substance testing devices with photo identification |
AU2003207552A1 (en) * | 2002-01-29 | 2003-09-02 | James D. Talton | Methods of collecting and analyzing human breath |
US20060160134A1 (en) * | 2002-10-21 | 2006-07-20 | Melker Richard J | Novel application of biosensors for diagnosis and treatment of disease |
US20130190639A1 (en) * | 2002-12-20 | 2013-07-25 | The Charlotte-Mecklenburg Hospital Authority | Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia |
EP1571987A2 (de) * | 2002-12-20 | 2005-09-14 | Amidex, Inc. | Atem-aerosol-entnahmesystem und -verfahren |
JP4555820B2 (ja) * | 2003-02-10 | 2010-10-06 | ウオーターズ・テクノロジーズ・コーポレイシヨン | シリコン上の脱離/イオン化質量分析(dios−ms)を使用した周囲空気の成分の吸着、検出、および同定 |
US20050013749A1 (en) * | 2003-03-27 | 2005-01-20 | Mcallister Clinton J. | One piece catalytic converter housing with integral end cone |
JP3800422B2 (ja) | 2003-03-31 | 2006-07-26 | 株式会社日立製作所 | 特定薬物の探知方法及び探知装置 |
JP2004361160A (ja) | 2003-06-03 | 2004-12-24 | Terametsukusu Kk | 呼気凝縮液採取装置 |
CA2433975C (en) * | 2003-06-27 | 2012-01-17 | Dana Canada Corporation | Ribbed mounting bracket for heat exchangers |
US20050048660A1 (en) * | 2003-09-02 | 2005-03-03 | Case Western Reserve University | Biomarker of maternal alcohol use during pregnancy |
US9022027B2 (en) * | 2004-02-20 | 2015-05-05 | Pneumoflex Systems, Llc | Nebulizer with intra-oral vibrating mesh |
US7857767B2 (en) * | 2004-04-19 | 2010-12-28 | Invention Science Fund I, Llc | Lumen-traveling device |
US7713849B2 (en) * | 2004-08-20 | 2010-05-11 | Illuminex Corporation | Metallic nanowire arrays and methods for making and using same |
US7450227B2 (en) | 2004-09-22 | 2008-11-11 | The Penn State Research Foundation | Surface enhanced Raman spectroscopy (SERS) substrates exhibiting uniform high enhancement and stability |
DE102004049064B3 (de) * | 2004-10-08 | 2006-05-18 | Dräger Safety AG & Co. KGaA | Verfahren zur Unterscheidung von Nass- und Trockengas mit einem Atemalkoholmessgerät |
US7393692B2 (en) | 2004-10-18 | 2008-07-01 | Real-Time Analyzers, Inc. | SERS method for rapid pharmacokinetic analysis of drugs in saliva |
GB2419940B (en) | 2004-11-04 | 2007-03-07 | Mesophotonics Ltd | Metal nano-void photonic crystal for enhanced raman spectroscopy |
US8627821B2 (en) * | 2005-01-10 | 2014-01-14 | Pulmatrix, Inc. | Method and device for decreasing contamination |
US7279132B2 (en) | 2005-01-12 | 2007-10-09 | Delphi Technologies, Inc. | Chemical vapor sensor having an active and a passive measurement mode |
JP4564406B2 (ja) | 2005-05-25 | 2010-10-20 | 株式会社日立製作所 | 呼気捕集フィルタ、呼気収集装置、呼気分析システムおよび呼気分析方法 |
WO2007020640A2 (en) * | 2005-08-16 | 2007-02-22 | Oridion Medical 1987, Ltd. | Breath sampling device and method for using same |
UA82962C2 (en) * | 2005-12-02 | 2008-05-26 | Sms Demag Ag | Method and smelting unit for obtaining steel with high manganese and low carbon content |
US8002712B2 (en) * | 2006-01-26 | 2011-08-23 | Meka Vikas V | Breath and breath condensate analysis system and associated methods |
US8348853B2 (en) * | 2006-02-06 | 2013-01-08 | Deka Products Limited Partnership | System, method and device for aiding in the diagnosis of respiratory dysfunction |
WO2007103474A2 (en) | 2006-03-07 | 2007-09-13 | University Of Florida Research Foundation, Inc. | Drug adherence monitoring system |
US7414239B2 (en) * | 2006-04-27 | 2008-08-19 | Ricoh Company, Ltd. | Optical-scanning apparatus and image forming apparatus |
CN101490059A (zh) * | 2006-05-15 | 2009-07-22 | 南丹麦大学 | 可用作爆炸物探测标记物的卟啉原衍生物 |
JP4856514B2 (ja) | 2006-10-20 | 2012-01-18 | 株式会社日立製作所 | 呼気成分捕集器、呼気成分捕集装置、呼気成分捕集器の製造方法、呼気成分分析装置および呼気成分分析方法 |
WO2008088780A1 (en) * | 2007-01-12 | 2008-07-24 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Detection of nitric oxide by nanostructured sensor |
US8078334B2 (en) | 2007-01-23 | 2011-12-13 | Alan Goodrich | Unobtrusive system and method for monitoring the physiological condition of a target user of a vehicle |
WO2008092198A1 (en) * | 2007-01-31 | 2008-08-07 | Euan Roger Tovey | A collection device for sampling exhaled airstreams |
JP5011026B2 (ja) | 2007-08-21 | 2012-08-29 | シャープ株式会社 | 多孔質構造体を用いた特定ガス成分濃縮装置、及び特定ガス成分検出装置 |
GB0717433D0 (en) | 2007-09-07 | 2007-10-17 | Bedfont Scient Ltd | Apparatus and method |
WO2009039152A1 (en) * | 2007-09-17 | 2009-03-26 | The Research Foundation Of State University Of New York | Detection of h. pylori utilizing unlabeled urea |
US9976944B2 (en) | 2007-10-02 | 2018-05-22 | Pexa Ab | Collection and measurement of exhaled particles |
CN101354394B (zh) * | 2008-09-08 | 2012-10-10 | 尚沃医疗电子无锡有限公司 | 呼气一氧化氮检测装置 |
US20100121210A1 (en) * | 2008-10-15 | 2010-05-13 | University Of Memphis Research Foundation | Method and device for detection ofanalyte in vapor or gaseous sample |
US20110009764A1 (en) * | 2009-04-14 | 2011-01-13 | Deka Product Limited Partnership | Devices, systems, and methods for aiding in the detection of a physiological abnormality |
WO2011017616A1 (en) * | 2009-08-06 | 2011-02-10 | Peter Theophilos Banos | Methods of and devices for monitoring the effects of cellular stress and damage resulting from radiation exposure |
US20110053173A1 (en) * | 2009-08-28 | 2011-03-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Game with detection capability |
CA3029712A1 (en) | 2009-09-09 | 2011-03-17 | Sensa Bues Ab | Drug detection in exhaled breath |
EP2498091A1 (de) | 2011-03-09 | 2012-09-12 | Sensa Bues AB | Fahrzeugverriegelungssystem und Verfahren basierend auf dem Nachweis von Analyten in der Ausatemluft |
EP2518499B1 (de) | 2011-03-09 | 2015-06-10 | Sensa Bues AB | Tragbare Probenahmevorrichtung und Verfahren für den Nachweis von Drogen in der Ausatemluft |
EP2823300B1 (de) | 2012-03-08 | 2019-10-09 | Sensa Bues AB | Verfahren zum nachweis von biomarkern in atemluft |
US9617582B2 (en) * | 2012-09-04 | 2017-04-11 | University Of Maryland College Park | Human exhaled aerosol droplet biomarker system and method |
EP3155758A4 (de) * | 2014-06-10 | 2018-04-11 | Sightline Innovation Inc. | System und verfahren zur netzwerkbasierten anwendungsentwicklung und -implementierung |
-
2010
- 2010-09-09 CA CA3029712A patent/CA3029712A1/en active Pending
- 2010-09-09 BR BR112012005198A patent/BR112012005198A8/pt not_active Application Discontinuation
- 2010-09-09 TR TR2018/02101T patent/TR201802101T4/tr unknown
- 2010-09-09 JP JP2012528364A patent/JP5992328B2/ja not_active Expired - Fee Related
- 2010-09-09 EP EP14164315.5A patent/EP2765421A1/de not_active Withdrawn
- 2010-09-09 EP EP14164314.8A patent/EP2765420B1/de active Active
- 2010-09-09 WO PCT/EP2010/063266 patent/WO2011029889A1/en active Application Filing
- 2010-09-09 CN CN201080040304.0A patent/CN102498398B/zh active Active
- 2010-09-09 HU HUE14164314A patent/HUE038136T2/hu unknown
- 2010-09-09 US US13/394,979 patent/US8368883B2/en not_active Expired - Fee Related
- 2010-09-09 NO NO14164314A patent/NO2765420T3/no unknown
- 2010-09-09 CA CA2771830A patent/CA2771830C/en active Active
- 2010-09-09 EA EA201270386A patent/EA023922B1/ru not_active IP Right Cessation
- 2010-09-09 WO PCT/EP2010/063265 patent/WO2011029888A1/en active Application Filing
- 2010-09-09 EP EP10751947.2A patent/EP2361387B1/de active Active
- 2010-09-09 ES ES14164314.8T patent/ES2659738T3/es active Active
- 2010-09-09 EP EP10754461.1A patent/EP2475977B1/de not_active Not-in-force
- 2010-09-09 US US13/394,609 patent/US10520439B2/en not_active Expired - Fee Related
- 2010-09-09 DK DK14164314.8T patent/DK2765420T3/en active
- 2010-09-09 MX MX2012002976A patent/MX2012002976A/es active IP Right Grant
- 2010-09-09 EP EP17201359.1A patent/EP3336543A1/de not_active Withdrawn
- 2010-09-09 EP EP15170749.4A patent/EP2982980A1/de not_active Withdrawn
- 2010-09-09 ES ES10751947.2T patent/ES2484515T3/es active Active
- 2010-09-09 AU AU2010294183A patent/AU2010294183B2/en not_active Ceased
-
2012
- 2012-02-22 ZA ZA2012/01304A patent/ZA201201304B/en unknown
-
2013
- 2013-01-11 US US13/739,607 patent/US8705029B2/en active Active
-
2014
- 2014-03-24 US US14/222,696 patent/US20140204374A1/en not_active Abandoned
- 2014-11-06 JP JP2014226506A patent/JP2015057607A/ja active Pending
-
2019
- 2019-11-08 US US16/678,761 patent/US11567011B2/en active Active
-
2022
- 2022-12-23 US US18/088,439 patent/US20230125894A1/en active Pending
Non-Patent Citations (1)
Title |
---|
None * |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2765420B1 (de) | Nachweis von Drogen in ausgeatmeter Luft | |
JP6332597B2 (ja) | 呼気から薬物物質をサンプリングするための携帯用サンプリングデバイス及び方法 | |
US10359417B2 (en) | Portable sampling device and method for detection of biomarkers in exhaled breath | |
JP2013504074A5 (de) | ||
CN104939831B (zh) | 从受试者的呼出气中收集样本的系统和方法及其用途 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20140411 |
|
AC | Divisional application: reference to earlier application |
Ref document number: 2361387 Country of ref document: EP Kind code of ref document: P |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR |
|
R17P | Request for examination filed (corrected) |
Effective date: 20150213 |
|
RBV | Designated contracting states (corrected) |
Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR |
|
17Q | First examination report despatched |
Effective date: 20150316 |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
INTG | Intention to grant announced |
Effective date: 20170425 |
|
GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
AC | Divisional application: reference to earlier application |
Ref document number: 2361387 Country of ref document: EP Kind code of ref document: P |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: EP Ref country code: GB Ref legal event code: FG4D Ref country code: AT Ref legal event code: REF Ref document number: 946780 Country of ref document: AT Kind code of ref document: T Effective date: 20171115 |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: FG4D |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R096 Ref document number: 602010046813 Country of ref document: DE |
|
REG | Reference to a national code |
Ref country code: DK Ref legal event code: T3 Effective date: 20180221 |
|
REG | Reference to a national code |
Ref country code: NL Ref legal event code: FP |
|
REG | Reference to a national code |
Ref country code: SE Ref legal event code: TRGR |
|
REG | Reference to a national code |
Ref country code: ES Ref legal event code: FG2A Ref document number: 2659738 Country of ref document: ES Kind code of ref document: T3 Effective date: 20180319 |
|
REG | Reference to a national code |
Ref country code: LT Ref legal event code: MG4D |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20171115 |
|
REG | Reference to a national code |
Ref country code: NO Ref legal event code: T2 Effective date: 20171115 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: HR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20171115 Ref country code: LV Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20171115 Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20180216 Ref country code: BG Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20180215 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20171115 Ref country code: EE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20171115 Ref country code: CY Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20171115 Ref country code: CZ Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20171115 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R097 Ref document number: 602010046813 Country of ref document: DE |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: RO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20171115 Ref country code: SM Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20171115 Ref country code: PL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20171115 |
|
PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 9 |
|
REG | Reference to a national code |
Ref country code: HU Ref legal event code: AG4A Ref document number: E038136 Country of ref document: HU |
|
26N | No opposition filed |
Effective date: 20180817 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20171115 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MC Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20171115 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20180909 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20180909 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: PT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20171115 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MK Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20171115 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: AL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20171115 Ref country code: IS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20180315 |
|
REG | Reference to a national code |
Ref country code: AT Ref legal event code: UEP Ref document number: 946780 Country of ref document: AT Kind code of ref document: T Effective date: 20171115 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: FR Payment date: 20220307 Year of fee payment: 13 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: NO Payment date: 20230323 Year of fee payment: 13 Ref country code: IE Payment date: 20230201 Year of fee payment: 13 Ref country code: FI Payment date: 20230322 Year of fee payment: 13 Ref country code: DK Payment date: 20230323 Year of fee payment: 13 Ref country code: CH Payment date: 20230323 Year of fee payment: 13 Ref country code: AT Payment date: 20230322 Year of fee payment: 13 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: TR Payment date: 20230130 Year of fee payment: 13 Ref country code: SE Payment date: 20230209 Year of fee payment: 13 Ref country code: IT Payment date: 20230322 Year of fee payment: 13 Ref country code: HU Payment date: 20230210 Year of fee payment: 13 Ref country code: GB Payment date: 20230130 Year of fee payment: 13 Ref country code: DE Payment date: 20230322 Year of fee payment: 13 Ref country code: BE Payment date: 20230322 Year of fee payment: 13 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: NL Payment date: 20230322 Year of fee payment: 13 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: ES Payment date: 20230629 Year of fee payment: 13 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R119 Ref document number: 602010046813 Country of ref document: DE |
|
REG | Reference to a national code |
Ref country code: DK Ref legal event code: EBP Effective date: 20230930 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: FI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20230909 |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PL Ref country code: SE Ref legal event code: EUG |
|
REG | Reference to a national code |
Ref country code: NL Ref legal event code: MM Effective date: 20231001 |
|
REG | Reference to a national code |
Ref country code: AT Ref legal event code: MM01 Ref document number: 946780 Country of ref document: AT Kind code of ref document: T Effective date: 20230909 |
|
REG | Reference to a national code |
Ref country code: BE Ref legal event code: MM Effective date: 20230930 |
|
GBPC | Gb: european patent ceased through non-payment of renewal fee |
Effective date: 20230909 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: NL Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20231001 |