EP2745829B1 - Antiperspirant compositions and method for reducing perspiration - Google Patents
Antiperspirant compositions and method for reducing perspiration Download PDFInfo
- Publication number
- EP2745829B1 EP2745829B1 EP14160729.1A EP14160729A EP2745829B1 EP 2745829 B1 EP2745829 B1 EP 2745829B1 EP 14160729 A EP14160729 A EP 14160729A EP 2745829 B1 EP2745829 B1 EP 2745829B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- weight
- less
- alum
- calcium chloride
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims description 130
- 230000001166 anti-perspirative effect Effects 0.000 title claims description 36
- 239000003213 antiperspirant Substances 0.000 title claims description 36
- 238000000034 method Methods 0.000 title claims description 22
- 229940037003 alum Drugs 0.000 claims description 66
- 150000003839 salts Chemical class 0.000 claims description 64
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical group [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 58
- 239000001110 calcium chloride Substances 0.000 claims description 51
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 51
- 239000007788 liquid Substances 0.000 claims description 51
- 239000003921 oil Substances 0.000 claims description 46
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 45
- 239000012876 carrier material Substances 0.000 claims description 27
- 239000000443 aerosol Substances 0.000 claims description 18
- 239000004411 aluminium Substances 0.000 claims description 14
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 14
- 229910052782 aluminium Inorganic materials 0.000 claims description 14
- 239000003380 propellant Substances 0.000 claims description 12
- 239000001164 aluminium sulphate Substances 0.000 claims description 9
- 235000011128 aluminium sulphate Nutrition 0.000 claims description 8
- 159000000007 calcium salts Chemical class 0.000 claims description 8
- BUACSMWVFUNQET-UHFFFAOYSA-H dialuminum;trisulfate;hydrate Chemical compound O.[Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O BUACSMWVFUNQET-UHFFFAOYSA-H 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 5
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 5
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 5
- 239000011591 potassium Substances 0.000 claims description 5
- 229910052700 potassium Inorganic materials 0.000 claims description 5
- 239000011734 sodium Substances 0.000 claims description 5
- 229910052708 sodium Inorganic materials 0.000 claims description 5
- 239000008247 solid mixture Substances 0.000 claims description 5
- 229910021653 sulphate ion Inorganic materials 0.000 claims description 5
- 229910052751 metal Inorganic materials 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 4
- 230000000699 topical effect Effects 0.000 claims description 3
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 229960002713 calcium chloride Drugs 0.000 description 37
- 235000011148 calcium chloride Nutrition 0.000 description 37
- 239000001993 wax Substances 0.000 description 21
- 239000002245 particle Substances 0.000 description 18
- 239000003349 gelling agent Substances 0.000 description 12
- -1 PPG-14 butyl ether Chemical class 0.000 description 10
- 239000004615 ingredient Substances 0.000 description 10
- 239000000843 powder Substances 0.000 description 10
- 235000011126 aluminium potassium sulphate Nutrition 0.000 description 9
- GNHOJBNSNUXZQA-UHFFFAOYSA-J potassium aluminium sulfate dodecahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.O.O.[Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GNHOJBNSNUXZQA-UHFFFAOYSA-J 0.000 description 9
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 8
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 8
- 239000002781 deodorant agent Substances 0.000 description 8
- DLAHAXOYRFRPFQ-UHFFFAOYSA-N dodecyl benzoate Chemical compound CCCCCCCCCCCCOC(=O)C1=CC=CC=C1 DLAHAXOYRFRPFQ-UHFFFAOYSA-N 0.000 description 8
- DCAYPVUWAIABOU-UHFFFAOYSA-N hexadecane Chemical compound CCCCCCCCCCCCCCCC DCAYPVUWAIABOU-UHFFFAOYSA-N 0.000 description 8
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 description 8
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 8
- 229940050271 potassium alum Drugs 0.000 description 8
- 239000007787 solid Substances 0.000 description 8
- 239000002537 cosmetic Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 229910052726 zirconium Chemical class 0.000 description 7
- DGSZGZSCHSQXFV-UHFFFAOYSA-N 2,3-bis(2-ethylhexanoyloxy)propyl 2-ethylhexanoate Chemical compound CCCCC(CC)C(=O)OCC(OC(=O)C(CC)CCCC)COC(=O)C(CC)CCCC DGSZGZSCHSQXFV-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical class [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 6
- 238000009826 distribution Methods 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 239000003205 fragrance Substances 0.000 description 6
- 230000036571 hydration Effects 0.000 description 6
- 238000006703 hydration reaction Methods 0.000 description 6
- 229930195733 hydrocarbon Natural products 0.000 description 6
- 150000002430 hydrocarbons Chemical class 0.000 description 6
- 238000003860 storage Methods 0.000 description 6
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 5
- 239000004698 Polyethylene Substances 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 5
- 229920000573 polyethylene Polymers 0.000 description 5
- 229920001223 polyethylene glycol Polymers 0.000 description 5
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000000375 suspending agent Substances 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 4
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical class [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 4
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 4
- 239000004359 castor oil Substances 0.000 description 4
- 235000019438 castor oil Nutrition 0.000 description 4
- 229940008099 dimethicone Drugs 0.000 description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 description 4
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 4
- 239000001282 iso-butane Substances 0.000 description 4
- 238000010902 jet-milling Methods 0.000 description 4
- 239000002480 mineral oil Substances 0.000 description 4
- 235000010446 mineral oil Nutrition 0.000 description 4
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 4
- 239000002304 perfume Substances 0.000 description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 4
- 239000001294 propane Substances 0.000 description 4
- 239000004215 Carbon black (E152) Substances 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 239000003570 air Substances 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 235000011124 aluminium ammonium sulphate Nutrition 0.000 description 3
- 210000001099 axilla Anatomy 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 239000001273 butane Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000004927 clay Substances 0.000 description 3
- 229940102552 disteardimonium hectorite Drugs 0.000 description 3
- 239000003974 emollient agent Substances 0.000 description 3
- 150000002191 fatty alcohols Chemical class 0.000 description 3
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical class ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 235000011127 sodium aluminium sulphate Nutrition 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 210000004243 sweat Anatomy 0.000 description 3
- NKJOXAZJBOMXID-UHFFFAOYSA-N 1,1'-Oxybisoctane Chemical compound CCCCCCCCOCCCCCCCC NKJOXAZJBOMXID-UHFFFAOYSA-N 0.000 description 2
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 description 2
- ULQISTXYYBZJSJ-UHFFFAOYSA-N 12-hydroxyoctadecanoic acid Chemical compound CCCCCCC(O)CCCCCCCCCCC(O)=O ULQISTXYYBZJSJ-UHFFFAOYSA-N 0.000 description 2
- WZUKKIPWIPZMAS-UHFFFAOYSA-K Ammonium alum Chemical compound [NH4+].O.O.O.O.O.O.O.O.O.O.O.O.[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O WZUKKIPWIPZMAS-UHFFFAOYSA-K 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 208000008454 Hyperhidrosis Diseases 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 229910000329 aluminium sulfate Inorganic materials 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 125000003368 amide group Chemical group 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 238000000149 argon plasma sintering Methods 0.000 description 2
- LLSDKQJKOVVTOJ-UHFFFAOYSA-L calcium chloride dihydrate Chemical compound O.O.[Cl-].[Cl-].[Ca+2] LLSDKQJKOVVTOJ-UHFFFAOYSA-L 0.000 description 2
- 229940052299 calcium chloride dihydrate Drugs 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 150000002170 ethers Chemical class 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- CRDAMVZIKSXKFV-UHFFFAOYSA-N farnesol Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- QWTDNUCVQCZILF-UHFFFAOYSA-N isopentane Chemical compound CCC(C)C QWTDNUCVQCZILF-UHFFFAOYSA-N 0.000 description 2
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 2
- 230000000873 masking effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000003607 modifier Substances 0.000 description 2
- 229940057874 phenyl trimethicone Drugs 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- 229920005573 silicon-containing polymer Polymers 0.000 description 2
- 235000015424 sodium Nutrition 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- LINXHFKHZLOLEI-UHFFFAOYSA-N trimethyl-[phenyl-bis(trimethylsilyloxy)silyl]oxysilane Chemical compound C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)C1=CC=CC=C1 LINXHFKHZLOLEI-UHFFFAOYSA-N 0.000 description 2
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 description 1
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 description 1
- PKGIJUSIJXTQFL-QFIPXVFZSA-N (4s)-5-(dibutylamino)-4-(dodecanoylamino)-5-oxopentanoic acid Chemical compound CCCCCCCCCCCC(=O)N[C@@H](CCC(O)=O)C(=O)N(CCCC)CCCC PKGIJUSIJXTQFL-QFIPXVFZSA-N 0.000 description 1
- RDMFQRSUPLBCIQ-SFHVURJKSA-N (4s)-5-(dibutylamino)-4-[ethyl(hexanoyl)amino]-5-oxopentanoic acid Chemical compound CCCCCC(=O)N(CC)[C@@H](CCC(O)=O)C(=O)N(CCCC)CCCC RDMFQRSUPLBCIQ-SFHVURJKSA-N 0.000 description 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 description 1
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
- NPNPZTNLOVBDOC-UHFFFAOYSA-N 1,1-difluoroethane Chemical compound CC(F)F NPNPZTNLOVBDOC-UHFFFAOYSA-N 0.000 description 1
- ARIWANIATODDMH-AWEZNQCLSA-N 1-lauroyl-sn-glycerol Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)CO ARIWANIATODDMH-AWEZNQCLSA-N 0.000 description 1
- ALDZNWBBPCZXGH-UHFFFAOYSA-N 12-hydroxyoctadecanamide Chemical class CCCCCCC(O)CCCCCCCCCCC(N)=O ALDZNWBBPCZXGH-UHFFFAOYSA-N 0.000 description 1
- 229940114072 12-hydroxystearic acid Drugs 0.000 description 1
- RMFFCSRJWUBPBJ-UHFFFAOYSA-N 15-hydroxypentadecyl benzoate Chemical compound OCCCCCCCCCCCCCCCOC(=O)C1=CC=CC=C1 RMFFCSRJWUBPBJ-UHFFFAOYSA-N 0.000 description 1
- KDTZBYPBMTXCSO-UHFFFAOYSA-N 2-phenoxyphenol Chemical compound OC1=CC=CC=C1OC1=CC=CC=C1 KDTZBYPBMTXCSO-UHFFFAOYSA-N 0.000 description 1
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 description 1
- 229910002016 Aerosil® 200 Inorganic materials 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 239000004135 Bone phosphate Substances 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 241001340526 Chrysoclista linneella Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- ARIWANIATODDMH-UHFFFAOYSA-N Lauric acid monoglyceride Natural products CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 description 1
- 229920001090 Polyaminopropyl biguanide Polymers 0.000 description 1
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 1
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 241000282485 Vulpes vulpes Species 0.000 description 1
- OGELJRHPEZALCC-UHFFFAOYSA-N [3-(2,3-dihydroxypropoxy)-2-hydroxypropyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCC(O)COCC(O)CO OGELJRHPEZALCC-UHFFFAOYSA-N 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- 150000001398 aluminium Chemical class 0.000 description 1
- 229960001422 aluminium chlorohydrate Drugs 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- SNCZNSNPXMPCGN-UHFFFAOYSA-N butanediamide Chemical class NC(=O)CCC(N)=O SNCZNSNPXMPCGN-UHFFFAOYSA-N 0.000 description 1
- 239000001175 calcium sulphate Substances 0.000 description 1
- 235000011132 calcium sulphate Nutrition 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- RLGQACBPNDBWTB-UHFFFAOYSA-N cetyltrimethylammonium ion Chemical class CCCCCCCCCCCCCCCC[N+](C)(C)C RLGQACBPNDBWTB-UHFFFAOYSA-N 0.000 description 1
- 238000012993 chemical processing Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- BFGKITSFLPAWGI-UHFFFAOYSA-N chromium(3+) Chemical compound [Cr+3] BFGKITSFLPAWGI-UHFFFAOYSA-N 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- LVYZJEPLMYTTGH-UHFFFAOYSA-H dialuminum chloride pentahydroxide dihydrate Chemical compound [Cl-].[Al+3].[OH-].[OH-].[Al+3].[OH-].[OH-].[OH-].O.O LVYZJEPLMYTTGH-UHFFFAOYSA-H 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- 229940031578 diisopropyl adipate Drugs 0.000 description 1
- AFABGHUZZDYHJO-UHFFFAOYSA-N dimethyl butane Natural products CCCC(C)C AFABGHUZZDYHJO-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 229940043259 farnesol Drugs 0.000 description 1
- 229930002886 farnesol Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000037315 hyperhidrosis Effects 0.000 description 1
- FMXLGOWFNZLJQK-UHFFFAOYSA-N hypochlorous acid;zirconium Chemical compound [Zr].ClO FMXLGOWFNZLJQK-UHFFFAOYSA-N 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 description 1
- 238000000399 optical microscopy Methods 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229940093424 polyaminopropyl biguanide Drugs 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000010944 pre-mature reactiony Methods 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 238000013341 scale-up Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 239000013585 weight reducing agent Substances 0.000 description 1
- 150000003754 zirconium Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
- A61K8/0229—Sticks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/044—Suspensions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
- A61K2800/31—Anhydrous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/87—Application Devices; Containers; Packaging
- A61K2800/874—Roll-on
Definitions
- the present invention is in the field of cosmetic compositions, in particular antiperspirant compositions and their use in reducing perspiration.
- compositions have been marketed for many years. They serve to reduce perspiration, particularly following application to the surface of the body. Such compositions are typically considered cosmetic products, although certain countries do classify the active ingredients most commonly used in such compositions as pharmaceutical agents. The compositions are most commonly applied to the underarm regions of the human body.
- the active ingredients most commonly used in antiperspirant compositions are astringent chlorohydroxide salts of aluminium and/or zirconium. These active ingredients are synthetic in origin, prepared in chemical plants and generally involving relatively advanced chemical processing steps. Such processing is not only expensive, but can also have significant environmental impact in terms of energy consumption.
- Alum salts have been disclosed as suitable for use in a range of deodorant compositions and, indeed, such products have been marketed.
- EP 1,974,716 A (Sara Lee, 2007 ) and WO 08/120976 (Sara Lee, 2008 ) disclose cosmetic compositions, for instance deodorant compositions, comprising at least partially dehydrated aluminium sulphate and a carrier liquid other than water.
- Crystal Spring Ltd. offer or have offered a range of natural deodorants based upon the deodorising effect of potassium alum.
- Green Bear UK Ltd. offer or have offered a crystal alum deodorant stick.
- US 133,430 discloses the manufacture of a deodorising powder by mixing/grinding together aluminium sulphate (sulphate of alumina or "alum”) and calcium chloride.
- WO 2011/076569 discloses anhydrous antiperspirant compositions comprising an alum salt.
- An objective of the present invention is to provide effective antiperspirant compositions the manufacture of which involves relatively low cost and relatively little environmental impact.
- the method and compositions of the invention may be seen as having good "natural" credentials, involving natural antiperspirant ingredients or at least naturally-derived antiperspirant ingredients.
- a further objective of the present invention is to provide high efficacy antiperspirant compositions.
- a further objective of the present invention is to provide a highly effective method of reducing perspiration and it is a particular objective that said method does not involve the use of synthetic aluminium and/or zirconium chlorohydroxide antiperspirant actives such as aluminium chlorohydrate.
- compositions containing astringent chlorohydroxide salts of aluminium and/or zirconium a wide range of liquids may be employed as carrier materials. These liquids are used to disperse and suspend the particulate antiperspirant chlorohydroxide salts of aluminium and/or zirconium within the composition. They may additionally be selected to provide emollient and deposit masking benefits.
- the carrier liquid needs to be selected with care in order to avoid issues during manufacture and subsequent storage of the formulation.
- liquids having a Hildebrand Solubility Parameter (HSP) of above 18.02 (MPa) 0.5 are employed their level of usage must be restricted. Failure to do so can result in formulations that are unstable with respect to their rheology and physical properties. Aerosol base compositions may set solid or become gritty during preparation or upon subsequent storage. Stick compositions can be formed that are undesirably soft. This is particularly the case where stearyl alcohol is used as the primary stick structurant, i.e., the structurant used in the highest weight percentage. Another problem is that stick formulations may become extremely hard upon storage, such as to make them unusable. It is hypothesised that the alum and calcium chloride react together, mediated by the relatively polar liquid.
- an anhydrous antiperspirant composition comprising a dehydrated alum salt, a water soluble calcium salt, and a liquid carrier material comprising 80% or more by weight of oils having a Hildebrand solubility parameter of 18.02 (MPa) 0.5 or less, wherein the water soluble calcium salt is calcium chloride and the molar ratio of calcium chloride to alum salt is greater than 1:1.
- a non-therapeutic method of reducing perspiration of the human body comprising the topical application of a composition according to the first aspect of the invention.
- anhydrous antiperspirant composition comprising the reduction in water content of an alum salt and the combination of the resulting dehydrated alum salt with calcium chloride and a liquid carrier material comprising 80% or more by weight of oils having a Hildebrand solubility parameter of 18.02 (MPa) 0.5 or less, wherein the dehydrated alum salt and calcium chloride are combined to give a molar ratio of calcium chloride to alum salt that is greater than 1:1.
- the method for reducing perspiration described herein is for reducing perspiration from the surface of the human body, in particular from the underarm areas and the feet and especially from the underarm areas, otherwise known as the axillae.
- the method may generally be considered a cosmetic method and compositions used in achieving the method, cosmetic compositions. That being said, the method can be extremely effective and compositions of the invention may be also used to treat the medical condition of extreme sweating known as hyperhidrosis.
- the method typically involves topical application of a composition according to the first aspect of the invention directly to the surface of the human body.
- the composition may be applied indirectly to the surface of the human body, for example by application of said composition onto a wipe which is in turn applied to the surface of the human body.
- the term "dried powder” should be understood to include both crystalline and amorphous states of matter. Such powders have a water content that is reduced from that of the most hydrated natural salt of the particular salt being used. More is said concerning preferred “dried powders” in the paragraphs described preferred alum salts and preferred calcium chloride salts.
- dehydrated when used with reference to a salt should be understood to refer to a salt that has a water content that is reduced from that of the most hydrated natural salt of the particular salt being used.
- anhydrous should be understood to mean having less than 2% by weight of free water; "free water” being water other than the water of hydration associated with any particular component.
- anhydrous compositions have less than 1% by weight free water and more preferably less than 0.5%.
- liquid should be understood to refer to a state of matter at ambient temperature and pressure, by which is meant 20°C and 1 atmosphere.
- oil should be understood to refer to a substance immiscible with water that is a liquid at ambient temperature and pressure.
- anhydrous compositions have a total water content (including water of hydration associated with components therein) of less than 10% by weight, and more preferably less than 5%.
- alum salt as used in the present description means aluminium sulphate (sometimes called “alum") or any double sulphate of aluminium and a univalent metal ion selected from potassium, sodium, or ammonium. It does not include alum salts that are double sulphates of a univalent metal and a trivalent metal other than aluminium, such as chromium (III) or iron (III).
- Alum salts for use in the present invention are potassium alum, ammonium alum, sodium alum and aluminium sulphate. That is to say: M(i)Al(SO 4 ) 2 or Al 2 (SO 4 ) 3 wherein M(i) is K + , Na + , NH 4 + or mixture thereof.
- Preferred alum salts are ammonium and potassium alum, in particular potassium alum.
- Alum salts used in the present invention have a reduced content of water, that is to say, they are at least partially dehydrated. They may alternatively be described as dried powders ( vide supra ). It has been found that use of such salts improves ease of formulation and/or leads to improved storage stability for the composition.
- Potassium alum dodecahydrate has been found to be particularly difficult to formulate with calcium chloride; however, reducing its water content by 25% or greater can lead to acceptable compositions.
- Typical alum salts for use in present invention have a water content of less than 35% by weight.
- Preferred alum salts have a water content of less than 28% by weight and especially preferred alum salts have a water content of less than 20% by weight. When water is present, it is typically present as water of hydration.
- the alum salt used in the present invention is typically milled to give it a reduced particle size.
- the particle size distribution of the alum salt is such that its D50 is less than 75 microns, more preferably less than 50 microns, and most preferably less than 20 microns.
- the particle size distribution of the alum salt is preferably such that less than 5% and more preferably less than 1% by weight of the particles have a particle size of greater than 100 microns.
- the particle size distribution of the alum salt may advantageously be measured using a light scattering method on a Sympatec GmbH Helos machine with an Oasis dry powder disperser and using an air pressure of 0.5 bar (50,000 Pa) and analysing results using Frauhoffer theory.
- the water soluble calcium salt used in the present invention is calcium chloride.
- the calcium chloride is a dried powder ( vide supra ). It is highly preferred that the calcium chloride has a water content of 25% or less. Suitable calcium chloride salts for such compositions include calcium chloride dihydrate and anhydrous calcium chloride, with anhydrous calcium chloride being preferred. It should be noted, however, than anhydrous calcium chloride as obtained from some suppliers can include up to about 14% by weight of water of hydration.
- the calcium chloride used in the present invention is typically milled to give it a reduced particle size. In preferred embodiments, the particle size distribution of the calcium chloride is such that its D50 is less than 100 microns and preferably less than 75 microns. The particle size distribution of the calcium chloride is preferably such that less than 5% and more preferably less than 1% by weight of the particles have a particle size of greater than 100 microns.
- the particle size distribution of the alum salt may advantageously be measured using a light scattering method on a Sympatec GmbH Helos machine with an Oasis dry powder disperser and using an air pressure of 0.5 bar (50,000 Pa) and analysing results using Frauhoffer theory.
- the potassium ion (K + ) may be substituted by sodium (Na + ) or ammonium (NH 4 + ).
- the stoichiometry of the above equations requires one mole of alum to two moles of calcium chloride in the first and one mole of alum to three moles of calcium chloride in the second.
- These equations set the basis for the preferred ratios of these components in compositions according to the invention.
- the molar quantity of calcium chloride exceeds the molar quantity of alum salt.
- the quantity of calcium chloride at least matches that stoichiometrically required by the above equations, relative to the amount and type of alum present. This means that it is preferred that the molar ratio of calcium chloride to alum salt is at least 2:1.
- compositions comprising calcium chloride and sodium, potassium or ammonium alum as the major alum salt present, the molar ratio of calcium chloride to alum salt is preferably from 1:1 to 5:1, more preferably from 3:2 to 3:1, and most preferably about 2:1.
- the molar ratio of calcium chloride to alum salt is preferably from 2:1 to 6:1, more preferably from 5:2 to 4:1, and most preferably about 3:1.
- reaction indicated above only occurs to a minimal extent before the components are delivered to the surface of the human skin.
- Premature reaction results in a physical state of matter which tends not to deliver the desired benefits; indeed, it is commonly extremely difficult to even apply said matter to the desired location.
- the chemical reaction involved in the present invention may only occur when the ions making up the reactants have sufficient mobility. In certain preferred embodiments of the present invention, this mobility typically arises when the reactants dissolve in aqueous body fluids found on the surface of the human body.
- Magnesium chloride was found to be ineffective when used instead of calcium chloride because of the much greater water solubility of magnesium sulphate compared with calcium sulphate.
- a third essential component of the invention is a liquid carrier material comprising 80% or more by weight of oils having a HSP of 18.02 (MPa) 0.5 or less.
- the liquid carrier material comprises 85% or more of such oils and more preferably 90% or more.
- liquid carrier material may only comprise liquids having a HSP of greater than 18.02 (MPa) 0.5 in an amount of less than 20%, preferably less than 10%, and more preferably less than 5% by weight.
- a stick or soft solid composition comprising a dehydrated alum salt, a water soluble calcium salt, and a liquid carrier material comprising 85% or more by weight of oils having a HSP of 18.02 (MPa) 0.5 or less.
- the liquid carrier material preferably comprises 90% or more and more preferably 95% or more by weight of oils having a HSP of 18.02 (MPa) 0.5 or less.
- the liquid carrier material should be considered to include all the liquid components of the composition, including liquid fragrance components, when present.
- HSPs for many cosmetic liquids can be obtained from the literature, such as from C. D. Vaughan, J. Soc. Cosmet. Chem. (1985), 36, 319-333 or from Table 1 in US 2010/0047296 (Henkel ).
- literature values may be calculated using methods described in the above reference or the methods described by S. W. van Krevelen in Properties of Polymers, p200-225, Elsevier, (1990 ).
- Suitable oils having a HSP of 18.02 (MPa) 0.5 or less are triethylhexanoin, isopropyl myristate, isopropyl palmitate, diisopropyl adipate, hexadecane, C12-15 alkyl benzoate, dioctyl ether, white mineral oil, dimethicone fluid, phenyl trimethicone and cyclomethicones such as cyclopentasiloxane.
- the liquid carrier material comprises 80% or more by weight of oils selected from this list.
- the liquid carrier material comprising 80% or more by weight of oils having a HSP of 18.02 (MPa) 0.5 or less preferably comprises oils having a HSP of 16.36 (MPa) 0.5 or less. In preferred embodiments, the liquid carrier material comprises 80% or more by weight of oils having a HSP of 16.36 (MPa) 0.5 or less.
- Suitable oils having a HSP of 16.36 (MPa) 0.5 or less are hexadecane, C12-15 alkyl benzoate, isopropyl palmitate, dioctyl ether, white mineral oil, dimethicone fluid, phenyl trimethicone and cyclomethicones such as cyclopentasiloxane.
- the liquid carrier material comprises 85% or more by weight of oils selected from this list.
- Oils with a HSP of greater than 18.02 (MPa) 0.5 that can be included include ethers, such as PPG-14 butyl ether, and fatty alcohols, such as octyl dodecanol and isocetyl alcohol.
- Preferred components of the liquid carrier material also perform an addition function; particularly preferred functions being to act as emollients and/or masking liquids.
- liquid carrier material preferred components of the liquid carrier material are anhydrous, as described hereinabove. Preferably, they contain less than 2%, more preferably less than 1% and most preferably less than 0.5% by weight free water.
- the liquid carrier material is preferably included in the composition at a level of 1-90%, more preferably at from 10 to 80% and most preferably at from 20 to 70% by weight of the composition, excluding any propellant that might also be present.
- Oils having a HSP of 18.02 (MPa) 0.5 or less are preferably included in the composition at a level of 1-90%, more preferably at from 10 to 80% and most preferably at from 20 to 70% by weight of the composition, excluding any propellant that might also be present.
- compositions used in accordance with the invention may also be included in compositions used in accordance with the invention.
- Additional antiperspirant actives may also be included.
- the total amount of antiperspirant actives, including dehydrated alum salt and calcium chloride, incorporated in a composition is preferably from 0.5-50%, particularly from 1 to 30% and especially from 2% to 26% of the weight of the composition.
- Antiperspirant actives used in addition to the alum salt and calcium chloride combination are often selected from astringent active salts, including in particular aluminium, zirconium and mixed aluminium/zirconium salts.
- Preferred additional antiperspirant actives are aluminium, zirconium and aluminium/zirconium halides and halohydrate salts, such as chlorohydrates.
- aluminium halohydrate salts are known as activated aluminium chlorohydrates and are made by methods known in the art.
- Suitable zirconium actives are represented by the empirical general formula: ZrO(OH) 2n-nz B z .wH 2 0 in which z is a variable in the range of from 0.9 to 2.0 so that the value 2n-nz is zero or positive, n is the valency of B, and B is selected from the group consisting of chloride, other halide, sulphamate, sulphate and mixtures thereof.
- Antiperspirant complexes based on the above-mentioned astringent aluminium and/or zirconium salts can be employed.
- the complex often employs a compound with an amino acid, such as glycine.
- the proportion of solid antiperspirant salt in a suspension composition normally includes the weight of any water of hydration and any complexing agent that may also be present in the solid active.
- deodorant actives may also be included.
- the level of incorporation is preferably from 0.01% to 3% and more preferably from 0.03% to 0.5% by weight.
- Preferred deodorant actives are those that are more efficacious than simple alcohols such as ethanol. Examples include quaternary ammonium compounds, like cetyltrimethylammonium salts; chlorhexidine and salts thereof; and diglycerol monocaprate, diglycerol monolaurate, glycerol monolaurate, and similar materials, as described in " Deodorant Ingredients", S.A.Makin and M.R.Lowry, in “Antiperspirants and Deodorants”, Ed. K. Laden (1999, Marcel Dekker, New York ).
- polyhexamethylene biguanide salts also known as polyaminopropyl biguanide salts
- an example being Cosmocil CQ available from Arch Chemicals
- 2',4,4'-trichloro,2-hydroxy-diphenyl ether triclosan
- 3,7,11-trimethyldodeca-2,6,10-trienol farnesol
- composition in which the invention may also be included.
- Types of composition in which the invention may be used include, non-exclusively, sticks, soft solids, aerosols, and roll-ons.
- Stick or soft solid compositions typically comprise one or more structurants or gellants, which serves to thicken the composition.
- Such thickeners referred to as structurant systems, may be selected from those known in the art for such purpose.
- the present inventors have found the choice of structurants to be of particular importance when the alum salt and calcium chloride are included in the same composition.
- particularly suitable structurant systems comprise:
- structurant and gellants suitable for use in compositions according to the present invention may be classed as waxes or non-polymeric fibre-forming gellants.
- “Waxes” may be defined as water-insoluble materials that are solid at 30°C and preferably also at 40°C. They may be selected from hydrocarbons, linear fatty alcohols, silicone polymers, esters waxes or mixtures thereof.
- hydrocarbon waxes examples include paraffin wax, ozakerite, microcrystalline wax and polyethylene wax, the last named desirably having an average molecular weight of from 300 to 600 and advantageously from 350 to 525.
- Linear fatty alcohols commonly contain from 14 to 40 carbon atoms and often from 16 to 24. In practice, most contain an even number of carbon atoms and many comprise a mixture of compounds, even those that are nominally a single one such as stearyl alcohol.
- Silicone polymer waxes typically satisfy the empirical formula:- 1. R-(SiMe 2 -O-) x -SiMe 2 R in which x is at least 10, preferably 10 to 50 and R represents an alkyl group containing at least 20 carbons, preferably 25 to 40 carbons, and particularly having an average linear chain length of at least 30 carbons; or 2.
- Y-(SiMe 2 -O-) y (Si[OR']Me-O-) z -Y' in which Y represents SiMe 2 -O, Y'SiMe 2 , R' an alkyl of at least 15 carbons preferably 18 to 22 such as stearyl, y and z are both integers, totalling preferably from 10 to 50.
- ester waxes include esters of C 16 -C 22 fatty acids with glycerol or ethylene glycol, which can be isolated from natural products or more conveniently synthesised from the respective aliphatic alcohol and carboxylic acid.
- Non-polymeric fibre-forming gellants are capable of being dissolved in a water-immiscible blend of oils at elevated temperature and on cooling precipitating out to form a network of very thin strands that are typically no more than a few molecules wide.
- One particularly effective category of such thickeners comprises N-acyl aminoacid amides and in particular linear and branched N-acyl glutamic acid dialkylamides, such as in particular N-lauroyl glutamic acid di n-butylamide and N-ethylhexanoyl glutamic acid di n-butylamide and especially mixtures thereof.
- Such amido gellants can be employed in anhydrous compositions according to the present invention, if desired, with 12-hydroxystearic acid.
- non-polymeric fibre-forming gellants include 12-hydroxystearic acid amides, and amide derivatives of di- and tri-basic carboxylic acids as set forth in WO 98/27954 , including notably alkyl N,N'dialkyl succinamides.
- the structurant or gellant is often employed in the stick or soft solid composition at a concentration of from 1.5 to 30%.
- concentration is typically in the range of from 1.5 to 7.5% by weight for amido gellants or mixtures of them and for 5 to 15% for ester or sterol gellants.
- concentration is usually selected in the range of from 10 to 30% by weight, and particularly from 12 to 24% by weight.
- Aerosol compositions are comprised of a propellant and a base.
- An aerosol "base” composition is considered to be all the components of the aerosol composition minus the propellant.
- propellants even when liquefied, are not liquids according to the present invention, as they have boiling points below 20°C at atmospheric pressure.
- the aerosol propellant is a liquefied hydrocarbon or halogenated hydrocarbon gases (particularly fluorinated hydrocarbons such as 1,1-difluoroethane and/or 1-trifluoro-2-fluoroethane) that have a boiling point of below 10°C and especially those with a boiling point below 0°C. It is especially preferred to employ liquefied hydrocarbon gases, and especially C 3 to C 6 hydrocarbons, including propane, butane, isobutane, pentane and isopentane and mixtures of two or more thereof.
- Preferred propellants are isobutane, isobutane/propane, butane/propane and mixtures of propane, isobutane and butane.
- propellants that can be contemplated include alkyl ethers, such as dimethyl ether or compressed non-reactive gasses such air, nitrogen or carbon dioxide.
- the propellant is typically the major component of aerosol compositions, often comprising from 30 to 99% weight and preferably comprising from 50 to 95% by weight.
- aerosol compositions may also comprise a suspending agent, for example, a hydrophobically modified clay, such as disteardimonium hectorite (Bentone 38V), ex Elementis, typically at from 0.1 to 1.5% by weight.
- a suspending agent for example, a hydrophobically modified clay, such as disteardimonium hectorite (Bentone 38V), ex Elementis, typically at from 0.1 to 1.5% by weight.
- Propylene carbonate may also be advantageously employed in aerosol compositions used in accordance with the present invention, typically at from 0.001 to 0.1% by weight.
- Roll-on compositions suitable for use in accordance with the invention are typically suspension products, in particular suspensions in one or more anhydrous liquid carrier materials ( vide supra ), hydrophobic liquid carrier materials being preferred.
- Roll-on compositions preferably comprise a suspending agent, for example, a hydrophobically modified clay, such as disteardimonium hectorite (Bentone 38V), ex Elementis, typically at from 0.5 to 3% by weight.
- a suspending agent for example, a hydrophobically modified clay, such as disteardimonium hectorite (Bentone 38V), ex Elementis, typically at from 0.5 to 3% by weight.
- Roll-on compositions preferably comprise a particulate sensory modifier, for example finely divided clay such as Aerosil 200, ex Evonik Degussa, typically at from 0.01 to 0.5% by weight.
- a particulate sensory modifier for example finely divided clay such as Aerosil 200, ex Evonik Degussa, typically at from 0.01 to 0.5% by weight.
- Other particulate sensory modifiers include particulate polyethylene (e.g. Acumist B18), talc and titanium dioxide.
- emulsifiers that are perfume solubilisers and/or wash-off agents are preferred additional components.
- the former include PEG-hydrogenated castor oil, available from BASF in the Cremaphor RH and CO ranges, preferably present at up to 1.5% by weight, more preferably 0.3 to 0.7% by weight.
- the latter include poly(oxyethylene) ethers.
- fragrance is a desirable additional component.
- suitable materials include conventional perfumes, such as perfume oils and also include so-called deo-perfumes, as described in EP 545,556 , for example.
- Levels of incorporation are preferably up to 5% by weight, particularly from 0.1% to 3.5% by weight, and especially from 0.5% to 2.5% by weight.
- the fragrance may also be added in an encapsulated form, release being triggered post-application by hydrolysis or shear on the surface of the human body.
- colourants and preservatives at a conventional level for example C 1 -C 3 alkyl parabens.
- compositions water miscible emollients such as polyethylenglycols (eg PEG 400) can be included, typically at levels up to 2% of the total composition.
- the method of manufacture of compositions according to the invention comprises an alum salt being reduced in water content prior to mixing with the calcium chloride and a liquid carrier material comprising 85% or more by weight of oils having a Hildebrand solubility parameter of 18.02 (MPa) 0.5 or less.
- the alum salt is preferably reduced in water content to less than 35%, more preferably less than 28% and most preferably less than 20% by weight.
- compositions according to the general formula indicated in Table 1 were prepared using the liquids listed in Table 2.
- Table 2 also gives details of the re-dispersibility characteristics of the compositions after storage at 45°C for 4 weeks.
- Table 1 Liquid Composition Component Amount (%) Dehydrated alum (14) 20 Calcium chloride (16) 14 Liquid carrier (see Table 2) 66
- Table 2 Liquid Compositions
- Example Liquid carrier HSP - (MPa) 0.5 Re-dispersibility 1 Dimethicone fluid (50cs) (4) 12.07 Easy 2 White mineral oil (5) 14.50 Difficult 3 C12-15 alkyl benzoate (2) 15.60 Difficult 4 Hexadecane (6) 16.36 Difficult 5 Isopropyl myristate (7) 16.40 Difficult 6 Triethylhexanoin (8) 18.02 Difficult A Octyl dodecanol (9) 18.25 Impossible B PPG-14-butyl ether (3) 18.61
- compositions according to the general formula indicated in Table 1 were prepared using mixtures of oils (making up 66% of the composition in total), as indicated in Table 3.
- Table 3 also gives details of the re-dispersibility characteristics of the compositions after storage at 45°C for 4 weeks.
- Table 3 Further Liquid Compositions Example Liquid carrier; Relative amount Re-dispersibility Oil: (1) (2) (8) (3) 7 50 50 0 0 Easy 8 38 38 24 0 Difficult 9 25 25 50 0 Difficult 10 47 47 0 6 Difficult D 38 38 0 24 Sticky E 25 25 0 50 Impossible
- Antiperspirant aerosol base compositions as indicated in Table 4 were prepared as follows. The oil or oils [components (1) (2) (3) and (8)] were blended at ambient temperature with the suspending agent [component (18)], followed by the propylene carbonate and fragrance, each being added with shear. Salts selected from components (14) to (17) as indicated were then added (calcium chloride first) and well dispersed into the mixture. The resulting base compositions were then assessed for consistency and stability.
- the aerosol base composition Example 13 was subsequently used to form a full aerosol composition.
- the base was placed into an aerosol cans which were closed with a standard valve and valve cup and the liquefied propellant (component (19)] then added.
- the weight ratio of base to propellant was 13:87.
- the antiperspirancy efficacy of the aerosol composition made from Example 13 was compared with that of a non-antiperspirant body spray control.
- Test operators applied the test composition (a two second spray - equivalent to approximately 2g application) to one axilla and a similar amount of the body spray control to the other axilla of each panellist. This was done once each day for three days. After the third application, panellists were requested not to wash under their arms for the following 24 hours.
- the panellists were induced to sweat in a hot-room at 40°C ( ⁇ 2°C) and 40% ( ⁇ 5%) relative humidity, for 40 minutes. After this period, the panellists left the hot-room and their axillae were carefully wiped dry. Pre-weighed cotton pads were then applied to each axilla of each panellist and the panellists re-entered the hot-room for a further 20 minutes. Following this period, the pads were removed and re-weighed, enabling the weight of sweat generated to be calculated.
- the sweat weight reduction (SWR) for each panellist was calculated as a percentage (% SWR) and the mean % SWR was calculated according to the method described by Murphy and Levine in “Analysis of Antiperspirant Efficacy Results", J. Soc. Cosmetic Chemists, 1991(May), 42, 167-197 .
- Example 3 was found to give a 23% greater SWR than the control.
- compositions were a stable, pourable base which remained pourable for at least three days at ambient temperature, despite each one containing low levels of liquid carrier materials having a HSP of greater than 18.02 (MPa) 0.5 .
- Example 19 is notable, octyl dodecanol (9) (an oil having a HSP of 18.25 (MPa) 0.5 ) comprising 11.7% of the liquid carrier material of this composition.
- Example 21 is also notable, PEG 8 (10) (a liquid having a HSP of 23.2 (MPa) 0.5 ) comprising 5.8% of the liquid carrier material of this composition.
- Compositions comprising water miscible humectants, of which PEG 8 is one, are particularly desirable because of their humectancy properties.
- the stick compositions indicated in Table 6 were prepared as follows.
- the oils [components (1) (2) (3) and (8)] were blended together at 90°C and the waxes [components (11) to (13)] were melted in with stirring.
- the mixtures were cooled to 75-85°C and salts selected from components (14) to (17) as indicated were added (calcium chloride first) and well dispersed into the mixture.
- the mixtures cooled to about 62°C and poured into stick barrels.
- Example 22 was used in an antiperspirancy efficacy test similar to the one used to test the full aerosol composition prepared from Example 13. A significant SWR was obtained using Example 22 (dosed at 0.3 g per application).
- Examples 22 and 23 were inferior to Examples 24 to 27, being less robust to processing conditions. Examples 22 and 23 became unacceptably soft when made at large (3 kg) scale, being intolerant of being processed at 80°C or higher for prolonged periods.
- Evidence of the superiority of Examples 24 to 27 over versions of Examples 22 and 23 processed at 85°C for two hours is given in Table 7 as penetrometer values. It will be seen that Examples 22A and 23A were very soft, having penetrometer values of greater than 15 mm. By contrast, Examples 24 to 27 (also processed at 85°C for two hours), each had acceptable penetrometer values of 7.3 mm to 9.6 mm. Table 7 Example: 22A 23A 24 25 26 27 Appearance Mushy Mushy Hard Hard Hard Hardness (mm) > 15 >15 7.3 8.9 9.6 7.5
- the penetrometer used to make the measurements indicated in Table 7 was a lab plant PNT penetrometer equipped with a Seta wax needle (weight 2.5 g) having a cone angle at the point of the needle of 9°10' +/- 15'.
- Each composition tested had a flat upper surface onto which the needle was lowered and penetration hardness was measured by allowing the needle with its holder to drop under the combined weight of needle and holder (50 g) for a period of five seconds. The test was carried out at six points on each sample and the results then averaged.
- the Examples indicated in Table 8 were prepared as follows. The oils were blended together at 95°C and the waxes were melted in with stirring at 90-95°C. When the waxes were fully melted, the mixtures were cooled to 85°C and salts selected as indicated were added (calcium chloride first) and well dispersed into the mixture. The mixtures were cooled to about 75°C and poured into stick barrels.
- Example 28 was found to give a significant SWR when tested using methodology similar to that used to test Examples 13 and 22.
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
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EP14160729.1A EP2745829B1 (en) | 2011-09-28 | 2011-12-19 | Antiperspirant compositions and method for reducing perspiration |
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EP11183152 | 2011-09-28 | ||
EP11194272.8A EP2574327B2 (en) | 2011-09-28 | 2011-12-19 | Antiperspirant compositions and method for reducing perspiration |
EP14160729.1A EP2745829B1 (en) | 2011-09-28 | 2011-12-19 | Antiperspirant compositions and method for reducing perspiration |
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EP11194272.8A Division EP2574327B2 (en) | 2011-09-28 | 2011-12-19 | Antiperspirant compositions and method for reducing perspiration |
EP11194272.8A Division-Into EP2574327B2 (en) | 2011-09-28 | 2011-12-19 | Antiperspirant compositions and method for reducing perspiration |
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EP2745829B1 true EP2745829B1 (en) | 2019-02-06 |
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EP14160729.1A Active EP2745829B1 (en) | 2011-09-28 | 2011-12-19 | Antiperspirant compositions and method for reducing perspiration |
EP11194272.8A Active EP2574327B2 (en) | 2011-09-28 | 2011-12-19 | Antiperspirant compositions and method for reducing perspiration |
EP12756509.1A Active EP2760414B1 (en) | 2011-09-28 | 2012-09-12 | Antiperspirant compositions and method for reducing perspiration |
EP12761579.7A Withdrawn EP2760415A2 (en) | 2011-09-28 | 2012-09-12 | Antiperspirant compositions and method for reducing perspiration |
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EP11194272.8A Active EP2574327B2 (en) | 2011-09-28 | 2011-12-19 | Antiperspirant compositions and method for reducing perspiration |
EP12756509.1A Active EP2760414B1 (en) | 2011-09-28 | 2012-09-12 | Antiperspirant compositions and method for reducing perspiration |
EP12761579.7A Withdrawn EP2760415A2 (en) | 2011-09-28 | 2012-09-12 | Antiperspirant compositions and method for reducing perspiration |
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US (2) | US20140227215A1 (pt) |
EP (4) | EP2745829B1 (pt) |
JP (2) | JP6063467B2 (pt) |
CN (2) | CN103826599A (pt) |
AR (2) | AR088068A1 (pt) |
AU (1) | AU2012314736B2 (pt) |
BR (2) | BR112014006289B1 (pt) |
EA (2) | EA032223B9 (pt) |
MX (2) | MX349854B (pt) |
WO (2) | WO2013045269A2 (pt) |
ZA (2) | ZA201401474B (pt) |
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EP2745829B1 (en) * | 2011-09-28 | 2019-02-06 | Unilever PLC | Antiperspirant compositions and method for reducing perspiration |
BR112015024792B1 (pt) * | 2013-04-03 | 2020-06-30 | Unilever N.V. | métodos para fabricar uma composição cosmética anidra |
US20150023886A1 (en) * | 2013-07-16 | 2015-01-22 | The Procter & Gamble Company | Antiperspirant Spray Devices and Compositions |
EP3079648A1 (en) | 2013-12-11 | 2016-10-19 | Colgate-Palmolive Company | Antiperspirant/deodorant composition |
US20150359819A1 (en) * | 2014-05-27 | 2015-12-17 | SS Health, Inc. | Topical formulation |
EA032891B9 (ru) * | 2014-12-15 | 2020-03-19 | Юнилевер Н.В. | Антиперспирантные композиции, содержащие квасцы |
DE102017006533A1 (de) * | 2017-07-11 | 2019-01-17 | Beiersdorf Ag | Wasserfreie Zusammensetzungen in Aerosolform, die ein oder mehrere suspendierte Elektrolyte enthalten |
JP7405540B2 (ja) | 2019-09-13 | 2023-12-26 | 株式会社シービック | 粒子状の制汗成分を含有する非含水化粧料 |
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US133430A (en) | 1872-11-26 | Improvement in disinfecting compounds | ||
US1872A (en) | 1840-12-01 | Improvement in the manner of forming oblique catches, protuberances | ||
US5232689A (en) * | 1990-12-21 | 1993-08-03 | Dow Corning Corporation | Translucent antiperspirant compositions |
JP3560989B2 (ja) | 1991-11-08 | 2004-09-02 | クウエスト・インターナシヨナル・ベー・ベー | 香料組成物 |
US5534246A (en) | 1994-08-29 | 1996-07-09 | Helene Curtis, Inc. | Topically-effective compositions |
US5840287A (en) | 1996-12-20 | 1998-11-24 | Procter & Gamble Company | Antiperspirant compositions containing gellants in the form of alkyl amides of di- and tri-carboxylic acids |
FR2781149B1 (fr) | 1998-07-17 | 2001-09-07 | Oreal | Composition deodorante contenant un sel d'alun |
US5955065A (en) * | 1998-08-19 | 1999-09-21 | The Gillette Company | Antiperspirant compositions containing calcium salts |
GB9908202D0 (en) | 1999-04-12 | 1999-06-02 | Unilever Plc | Cosmetic compositions |
EP1074246A1 (en) | 1999-07-23 | 2001-02-07 | Unilever Plc | Cosmetic composition containing a structurant |
GB0019231D0 (en) | 2000-08-04 | 2000-09-27 | Unilever Plc | Antiperspirant compositions |
US6321841B1 (en) | 2001-02-21 | 2001-11-27 | Halliburton Energy Services, Inc. | Methods of sealing pipe strings in disposal wells |
US6403071B1 (en) | 2001-03-05 | 2002-06-11 | The Procter & Gamble Company | Anhydrous antiperspirant and deodorant compositions containing solid d-pantothenate salts |
US6375938B1 (en) * | 2001-04-26 | 2002-04-23 | The Gillette Company | Antiperspirant and deodorant compositions containing a low molecular weight polyethylene gellant |
EP1465586B1 (en) | 2002-01-18 | 2007-04-11 | Unilever Plc | Cosmetic compositions comprising a cyclodipeptide compound |
WO2004037220A1 (ja) | 2002-10-25 | 2004-05-06 | Shiseido Company, Ltd. | 皮膚外用剤 |
JP4219794B2 (ja) * | 2003-12-01 | 2009-02-04 | 株式会社ノエビア | 制汗・防臭剤組成物 |
JP2007145771A (ja) * | 2005-11-29 | 2007-06-14 | Mandom Corp | 殺菌剤組成物及びデオドラント剤 |
DE102006053886A1 (de) | 2006-11-14 | 2008-05-15 | Henkel Kgaa | Rückstandsarmer kosmetischer oder dermatologischer Stift auf Basis einer Öl-in-Wasser-Dispersion/Emulsion III |
PL1974716T3 (pl) | 2007-03-30 | 2012-09-28 | Colgate Palmolive Europe Sarl | Kompozycja kosmetyczna zawierająca sól glinu |
JP2008303123A (ja) * | 2007-06-11 | 2008-12-18 | Ako Kasei Co Ltd | 塩化ナトリウムの結晶形状維持方法 |
US20110038823A1 (en) | 2009-08-13 | 2011-02-17 | The Dial Corporation | Antiperspirant emulsion products with improved efficacy and processes for making the same |
JP5587061B2 (ja) * | 2009-09-30 | 2014-09-10 | 三洋電機株式会社 | 抵抗溶接用通電ブロック、この通電ブロックを用いた密閉電池の製造方法及び密閉電池 |
DE102009055255A1 (de) * | 2009-12-23 | 2011-06-30 | Henkel AG & Co. KGaA, 40589 | Wasserfreie Antitranspirant-Sprays mit verbesserter Leistung |
WO2013013902A2 (en) * | 2011-07-22 | 2013-01-31 | L'oreal | Method for the treatment of human perspiration using a polyvalent cation salt and an anion salt |
EP2745829B1 (en) * | 2011-09-28 | 2019-02-06 | Unilever PLC | Antiperspirant compositions and method for reducing perspiration |
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