EP2736477A1 - Appareil portable de régulation thermique pour médicaments - Google Patents

Appareil portable de régulation thermique pour médicaments

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Publication number
EP2736477A1
EP2736477A1 EP12740141.2A EP12740141A EP2736477A1 EP 2736477 A1 EP2736477 A1 EP 2736477A1 EP 12740141 A EP12740141 A EP 12740141A EP 2736477 A1 EP2736477 A1 EP 2736477A1
Authority
EP
European Patent Office
Prior art keywords
temperature
accommodating chamber
regulating
medicament
medicament container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP12740141.2A
Other languages
German (de)
English (en)
Other versions
EP2736477B1 (fr
Inventor
Peter Lüpges
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP2736477A1 publication Critical patent/EP2736477A1/fr
Application granted granted Critical
Publication of EP2736477B1 publication Critical patent/EP2736477B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/16—Holders for containers
    • A61J1/165—Cooled holders, e.g. for medications, insulin, blood, plasma
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
    • F25B21/00—Machines, plants or systems, using electric or magnetic effects
    • F25B21/02—Machines, plants or systems, using electric or magnetic effects using Peltier effect; using Nernst-Ettinghausen effect
    • F25B21/04—Machines, plants or systems, using electric or magnetic effects using Peltier effect; using Nernst-Ettinghausen effect reversible

Definitions

  • the invention relates to a portable apparatus for regulating the temperature of medicaments in solid or liquid form.
  • US 2009/0100843 Al discloses a portable cooler for medicaments.
  • the cooler has receptacles for the medicaments to be cooled, a thermoelectric cooling system which releases the heat to the surroundings via cooling ribs in the interior of the housing, and a display for displaying user information.
  • a portable cooling device for cooling medicaments is known from document US 2008/0022696 Al .
  • a chamber of the cooling device can be adapted to the shape of a medicament container.
  • An aerogel insulator, for example, is provided as an insulator.
  • the cooling device furthermore comprises thermoelectric elements adjacent to the chamber walls.
  • Documents US 5, 7 1 3, 208, US 5, 865,032 discloses further examples of cooling devices for medicaments that comprise thermoelectric elements .
  • the hollow needle is attached to the medicament container for example by means of a screwing process with corresponding threads .
  • a desired dose can be injected using the medicament container, which has now been converted into a syringe.
  • Such a medicament container usually contains several times the a mount of a single dose. After a dose has been administered, the medicament container with the remaining content therefore has to be cooled again until the next dose is administered .
  • Such a medicament container which can be converted into a syringe at the same time can comprise a mechanism in order to be able to inject or administer a desired quantity of a medicament in a precise manner, even by a patient, i .e. a layman .
  • the used needle must be replaced with a sterile needle to administer a next dose, so as to avoid inflammation . Due to idleness, many patients do not replace the need le in this manner, which can promote inflammation, for example.
  • the invention is based on the object of providing an improved mobile temperature-regulating apparatus of the type mentioned in the introduction .
  • a temperature-regulating apparatus for medicaments which comprises a housing with at least one ac- commodating chamber for a medica ment container.
  • the accommodating chamber is intended a nd suitable to accommodate a medicament container. Subsequent to inserting the medicament container into the accommodating chamber, the accommodating chamber can be closed in order to minimize energy loss during a temperature-regulating process .
  • the accommodating chamber i .e. the inner space of the accommodating chamber, is preferably positively adapted to a medicament container located in the accommodating chamber in order to minimize the energy required for temperature regulation of the medicament located in the medic- ament container.
  • the temperature-regulating appa ratus comprises a temperature-regulating device, particularly a thermoelectric temperature-regulating device.
  • the temperature-regulating device comprises a power source, in par- ticular an electrical power source in the form of a battery or of a rechargeable battery.
  • this temperature-regulating apparatus serves for regulating the temperature of medicament containers that are simultaneously designed as ad ministering containers for administering a dose of a medicament, with the medicament container initially containing several times the amount of such a dose. Subsequent to the administration of a dose, such a medicament container must therefore be temperature- regulated again .
  • the temperature-regulating apparatus serves for regulating the temperature of medicament containers that can be converted into syringes . Therefore, the invention in one embodiment also relates to a temperature-regulating apparatus in which a medica ment container is disposed for temperature regulation, wherein the medicament container, at the sa me time, is an administering conta iner or can be configured as an administering container.
  • This temperature-regulating apparatus comprises at least one of the features mentioned below, or is configured in at least one of the ways mentioned below in order to achieve the object of the invention .
  • the temperature-regulating device is configured in such a way that it is capa ble of regulating the temperature of only a partial area of the accommodating chamber.
  • a medicament is located only in a partial area of a med icament container.
  • a portion of such a medicament container comprises a mechanism, e.g . a movable piston, in order to be a ble to press the medica ment through a hollow needle out from the medicament container using the piston .
  • a mechanism for being able to very precisely move the piston for example by means of rotary movements, at least in the direction of the area which in- eludes or can include the hollow needle, can be provided additionally.
  • This part of the medicament container which comprises, for example, a piston as well as, optionally, a mechanism for moving the piston, need not be temperature-regulated in order to suitably regulate the temperature of the medicament located in the container. Since such a mechanism, including the piston, is connected to the medicament container, this mechanism, including the piston, is also disposed in the temperature-regulating a pparatus when the medicament container has been inserted into the accommodating chamber. It is therefore sufficient to be able to regulate the temperature of only a pa rtial area of the accommodating chamber in order to keep the medicament at the desired temperature.
  • the temperature- regulating device is designed and configured in such a way that it is capable of regulating the temperature of only this partial area of the accommodating cha mber in order to thus minimize the energy demand for the desired temperature regulation and therefore enable long operating times of the temperature-regulating apparatus independent from an external power source.
  • temperature-regulating elements such as, for example, thermoelectric temperature-regulating elements are disposed adjacent to such areas in which the part or section of the medicament container comprising the medicament is disposed given proper insertion . Tempera- ture-regulating elements thus particularly do not adjoin such areas or sections of the accommodating chamber in which, given proper insertion, the section or area of a medicament container is disposed that does not contain any medicament, but, for example a mechanism and a piston .
  • the temperature-regulating a pparatus is configured so as to be capable of temperature regulation independently from a stationary power source, for example by means of a battery of the temperature-regulating apparatus, then the temperature can be regulated over a particularly long period of time independently from a stationary power source. Long operating times are therefore possible. The mobility of the temperature-regulating a pparatus is improved accordingly.
  • the accommodating chamber has a n elongate shape.
  • the temperature-regulating device is basically configured in such a way that it is temperature-regulated only over a partial distance along the extended form, generally starting at one end of the elongate form u p to a middle area located between the two end areas of the elongate form .
  • One or more cooling and/or heating elements preferably Peltier elements, i .e. thermoelectric elements, are in that case disposed along a section adja- cent to the accommodating chamber, and not along the entire elongate form .
  • the temperature-regulating device is configured in such a way that not the entire length of the accommodating chamber is or can be temperature-regulated, but only a section thereof .
  • the one or more cooling and/or heating elements which can preferably be operated electrically, can be disposed distributed around the circumference of the accommodating chamber, or only at one long side of the accommodating chamber.
  • the a rea or section of the accommodating chamber that is to be temperature-regulated and to which the one or more cooling a nd/or heating elements is adjacent consists of metal or a material with a compa- rably good thermal conductivity. Copper or aluminum is preferably provided as a metal .
  • the accommodating chamber is formed by a material of relatively poor thermal conductivity, particularly by plastic, in order to keep the weight of the temperature-regulating apparatus low and thus increase mobility.
  • the temperature-regulating apparatus comprises an alignment device which permits an insertion of the medica ment container in only one direction or exactly one manner. It is thus ensured that the area or section of a n inserted medicament container in which the medicament is located can be or is temperature-regulated .
  • the med icament container can therefore not be brought into the accommodating chamber in such a way that an area of the medicament container is subsequently temperature- regulated in which no medicament is located .
  • the alignment device comprises a fastening means, in particular a thread, a bayonet connecting means or a latching means for detachably fastening the med icament container.
  • Fastening the medicament container in the accommodating chamber limits the mobility within the accommodating chamber. It is thus ensured in a further improved manner that the area of the inserted medicament container comprising the medica ment is temperature-regulated .
  • the medicament container comprises a section to which a hollow needle can be detachably fastened .
  • This section comprises, for example, a n external thread onto which the internal thread of a hollow needle can be screwed .
  • the fastening means of the medicament container is configured in such a way that this section of the medicament container at the same time serves for fastening in the accommodating chamber.
  • the fastening means of the temperature-regulating appa ratus comprises a thread corresponding therewith, in particular an internal thread, in order to be able to connect the thread of the medicament container to the thread of the fastening means by screwing .
  • the fastening means comprises a latching means corresponding therewith .
  • the fastening means comprises a latching means corresponding therewith .
  • the fastening mea ns on the one hand serves for aligning the medica ment container, since only one attachment direction or manner of fastening is possible.
  • the needle has to be removed from the medicament container in order to be able to fasten the medicament container in the accommodating chamber and, subsequent thereto, to store and temperature-regulate it.
  • the needle is not removed due to idleness or due to inattentiveness and replaced with a new, unused needle prior to a subsequent ad ministration of a medicament dose.
  • this temperature-regulating appa- ratus is not necessarily configured in such a way that only a partia l area of the accommodating chamber is temperature-regulated for the medicament.
  • this temperature-regulating apparatus can also be configured in such a way that the accommodating chamber is temperature-regulated over its entire area, i .e.
  • This temperature-regulating apparatus which relates to an independent invention independent from the configuration including the partial temperature regulation of the accommodating chamber, comprises a housing with at least one accommodating chamber for a medicament container, wherein the accommodating chamber, i .e. the inner space of the accommodating chamber, is preferably positively ada pted to a medicament container located in the accommodating chamber, as well as a temperature-regulating device with which the accommodating chamber and thus, also a medica- men ⁇ container in the accommodating chamber, can be temperature- regulated .
  • the temperature-regulating a pparatus comprises a storage chamber for storing one or more needles .
  • the reliable availability to the patient of unused needles is thus promoted, which promotes the use of a new needle as soon as a next medicament dose is to be administered .
  • the fastening means preferably comprises a detector that is capable of detecting the fastening of a medicament container.
  • the detector can be, for example, a micro switch which is actuated once the medicament container is fastened .
  • a capacitive or inductive detector can be used as a detector. Temperature regulation can be carried out only subsequent to such a n ac- tuation of the detector, as well as preferably only for the d uration of the actuation .
  • the accommodating chamber comprises a replaceable insert which preferably consists entirely or partially of metal .
  • This embodiment makes it possible to select and use an insert depending on the geometry of the medicament container. If the geometry of the medicament container to be temperature-regulated changes, it is suffi- cient if the insert in the accommodating chamber is replaced in order to be able to temperature-regulate a medicament container with a modified geometry. Every single insert is preferably adapted to the geometry of every single medicament container, i .e. shaped inside so as to be complementary to the medicament container in order thus to minimize the volume to be temperature-regulated .
  • Every single insert thus surrounds the medicament container in a preferably positive manner and has a geometry that is complementa ry thereto.
  • This configuration is not to be combined mandatorily with the above-mentioned embodiments, but represents an independent invention . It solves the problem that a temperature-regulating a pparatus can be modified with minimal effort in such a way that, depending on the geometry of a medicament container, the geometry in the accommodating chamber can be suitably adapted in order to minimize the energy dema nd for temperature regulation .
  • This temperature-regulating apparatus which relates to an independent invention, furthermore comprises a housing with at least one accommodating chamber for a medicament container, wherein the accommodating chamber is preferably positively adapted to a medicament container located in the accommodating chamber, as well as a temperature-regulating device with which the accommodating chamber can be temperature-regulated .
  • the insert can simultaneously comprise the aforementioned fastening means to which a medicament container can be fastened . I n that case, a fastening means can be replaced together with the insert.
  • the insert can advantageously be equipped with one or more cooling and/or heating elements, which can therefore be replaced together with the insert.
  • the aforementioned insert which is at least a part of the accommodating chamber, in particular consists of a metal which is coated on the inside with gold in order to be protected well against corrosion and have good thermal conductivity at the same time. Copper is preferred as the metal . If the insert consists only partially of metal, then that area and section of the insert consists of metal into which a section of the medicament holder comes which comprises the medicament. I n this embodiment, the insert furthermore preferably consists of a material that has poor thermal conductivity in com pari- son to the meta l, particularly of plastic, for weight-related reasons, in order thus to keep the weight low.
  • the temperature-regulating apparatus comprises a moisture sensor capable of detecting the moisture in the accommodating chamber. Furthermore, there is a control apparatus which controls the temperature regulation depending on the detected moisture.
  • the accommodating chamber is, in particular, heated and thus dried if an excessively high degree of moisture above a predetermined threshold value is detected or measured and if it is additionally detected by the temperature-regulating apparatus that no medicament container to be temperature-regulated is located in the accommodating chamber.
  • the accommodating chamber is thus protected against corrosion in an improved manner.
  • the temperature-regulating a pparatus comprises a filling level sensor, particularly an optical filling level sensor, with which the filling level in a medicament container located in the accommodating chamber can be determined .
  • a filling level sensor particularly an optical filling level sensor
  • the temperature- regulating apparatus comprises a loudspeaker and/or a display through which an alarm signal can be outputted, if necessary. F urthermore, this embodiment makes it possible to suitably reduce that area within the accommodating cha mber that is to be temperature-regulated .
  • Such a medicament container preferably comprises a piston which, owing to a correspondingly configured mecha nism, can only be moved in one direction by a patient. I n such medicament containers the volume in which the medicament is situated can only be reduced, but not increased .
  • the temperature-regulating apparatus is configured in such a way, or comprises such a detector that is capable of detecting the position of a piston of a medicament container.
  • the area adjacent to the volume with the medicament located therein can be temperature-regulated depending on the position of the piston .
  • the detection of the position of a piston can be used to indicate by means of an alarm signal a necessary replacement in the near future of the medicament container.
  • the medicament container comprises a detector which is ca pable of detecting and counting a n insertion and/or remova l of a medicament container from the accommodating chamber.
  • the temperature-regulating apparatus is thus capable of determining and storing how often a medicament container was removed and reinserted into the accommodating chamber.
  • This embodiment can be used to ind icate maintenance intervals and/or to ind icate by means of an a larm signal the necessity of replacing the med icament container.
  • the temperature-regulating apparatus is configured accordingly and comprises the devices and means necessary for this purpose.
  • the temperature-regulating apparatus comprises a disinfecting device with which the accommodating chamber can be disinfected .
  • the temperature-regulating a pparatus comprises an, in particular outer, insulating layer that comprises a gel or other substance which is brought into a different state of aggregation at or above room temperature when latent heat is supplied, generally from solid to liq uid .
  • the temperature for a phase tra nsition is, in particular, between 21 °C and 30°C . I n the case of an excessively warm environment above room temperature, the temperature-regulating apparatus is thus reliably protected against an excessively high heat supply into the accommodating chamber, without a considerable increase of, for example, electrica l power for operating electrical heating and/or cooling elements being connected therewith . Basically no phase transition occurs at room temperature.
  • the temperature-regulating apparatus comprises an, in particular inner, insulating layer that comprises a gel or other substance which is brought into a different state of aggregation at temperatures significantly below room temperature when latent heat is supplied, in particular from solid to liquid.
  • a phase transition occurs at a temperature below 12°C, preferably below 8°C.
  • this phase transition occurs at temperatures above 0°C, particularly preferably at temperatures above 2°C, particularly preferably at temperature above 4°C.
  • This embodiment contributes to being able to keep a medicament sufficiently cool over a longer period of time, independently from an external power supply, even if an electrical or other temperature regulation fails.
  • the layer in which the phase transition occurs at relatively low temperatures is enveloped by the layer in which the phase transition occurs at relatively high temperatures.
  • the two layers surround the accommodating chamber wholly or partially, preferably at least the area into which the medicament can get.
  • the temperature-regulating apparatus in one embodiment comprises an accommodating chamber which is wholly or partially enveloped by at least one layer comprising a gel or other substance that is brought into a different state of aggregation at temperatures between 0°C and 30°C when latent heat is supplied, in order thus to be able to ensure long operating times.
  • the inner walls of the accommodating chamber consist entirely or partially of metal, in particular copper.
  • the inner face of the accommodating chamber is coated with gold in order to avoid adverse effects due to corrosion.
  • a suitable temperature regulation is thus possible in a reliable manner.
  • a good protection against corrosion is provided due to the gold coating.
  • only a part of the accommodating chamber comprises metallic walls, i .e. the area in which a medicament container arrives with a section in which the medicament is located .
  • the accommodating chamber is preferably manufactured from a material with relatively poor thermal conductivity, such as plastic .
  • This area which consists of a material with relatively poor thermal conductivity, is preferably configured as a cap into which a medicament container located in the accommodating chamber generally extends partially.
  • This embodiment makes it possible to keep the technical effort small for producing an accommodating cha mber consisting in part of metal and in part of a nother material, because as a rule, a cap in any case has to be manufactured independently of a container that is a part of the accommodating chamber.
  • the cap is dimensioned in such a way that the cap extends, or is capable of extending, into the area of the medicament container that is not filled with the medicament.
  • the one or more heating and/or cooling elements with which temperature regulation can be carried out in a controlled manner are then preferably attached to the container.
  • thermoelectric elements such as Peltier elements
  • the thermoelectric elements are in that case fastened to the outside of the accommodating chamber, for example welded thereto.
  • the one or more thermoelectric elements such as, for instance, Peltier elements, serve for the temperature regulation of the medicament in the medicament container that has been inserted into the accommodating chamber.
  • the d istribution of the thermoelectric elements on the outside is limited, as a matter of principle, to the limited area of the accommodating chamber that is to be temperature-regulated .
  • the temperature-regulating a pparatus comprises a paraffin storage system as a cold storage system .
  • the accommodating chamber comprises a cap with which the accommodating chamber can be closed . If the cap is removed so that the accommodating chamber is no longer closed subsequent thereto, then an inserted medicament container protrudes in such a way that it can be grasped easily. Without the cap, the inner space of the accommodating chamber is therefore shorter than the length of a medicament container provided for this accommodating chamber.
  • a detector for example a micro switch, a capacitive, inductive or optica l sensor, which is capable of detecting whether the accommodating chamber has been closed with the cap.
  • F urthermore a control apparatus is provided which prevents a temperature regulation if the accommodating chamber has not been closed with the cap . The reliable minimization of the energy consumption is thus accomplished .
  • the outer shape of the accommodating chamber is cylindrical, and one end of the cylindrical shape is configured as a cap, preferably as a screw-on cap. If the cap is removed and if a medica ment container is disposed in the accommodating chamber, then the former in particular protrudes from the remaining part of the accommodating chamber. The medica ment container can then be grasped and removed easily.
  • the protruding part of the med icament container comprises the section which is not filled with a medicament. Therefore, the area of the cap is, in particular, an area of the medicament container which is not temperature- regulated .
  • a flat area with a preferably rectangular or square surface which comprises further components of the temperature-regulating apparatus, such as, for example, a display, electrical system a nd/or an electronic system, is attached to the side of the cylindrical shape of the accommodating chamber, i .e. between the two ends of the cylinder. If the cap is removed and if a medicament container is disposed in the accommodating chamber, then the medicament container not only protrudes from the remaining part of the accommodating chamber, but also laterally relative to the flat area which is attached to the side of the cylindrical accommodating chamber.
  • These geometry facilitates the operation of the temperature-regulating apparatus, particularly the removal of a medicament container, or the accommodation of a medicament container in the temperature-regulating apparatus inclusive of an optionally provided fastening in the accommodating chamber.
  • the medicament container on a surface, for example on the surface of a desk, in such a way that, on the one hand, it rests on the cylindrical area, and, on the other hand, on the laterally attached flat area, for example with a distal end of this area.
  • a surface of the laterally attached area is visible, which is in particular configured as a display, or a display.
  • a patient who is, for example, working at a desk is thus able at any time to have a look at the display, for example to inform himself of the operating states. Therefore, this shape also facilitates mobile handling.
  • the temperature-regulating apparatus in one embodiment of the invention, is configured in such a way that other information, such as the time, can also be displayed via the display.
  • the temperature-regulating apparatus can simultaneously be used, for example, as a desk clock.
  • the temperature-regulating apparatus can be configured in such a way that, alternatively or additionally, e-mails and other information, for example, can be called up and displayed via the display.
  • the temperature-regulating apparatus is configured in such a way that it can be connected to an external power source at any time. If, for example, the temperature-regulating apparatus is placed on a desk in an office, it can be electrically connected to an electric socket.
  • the temperature-regulating a pparatus comprises different menus that can be selected by the patient and which are preferably intended for different ages .
  • an age-appropriate menu is provided .
  • a menu in one embodiment therefore comprises particularly large depictions of letters a nd numbers and/or explanatory graphical representations . If a menu for a younger age is selected by input, then letters, numbers as well as graphical representations are shown smaller, so that a greater va- riety of information can be shown on the display at the same time.
  • a temperature-regulating apparatus comprising a housing with at least one accommodating chamber, as well as at least one temperature-regulating device for regulating the temperature of the accommodating chamber, in particular a thermoelectric temperature-regulating device, with at least one inputting means capable of registering an insertion of a med icament container into the accommodating chamber or an immediately imminent insertion, and of controlling the temperature regulation of the accommodating chamber depending thereon .
  • other cha mbers of the temperature-regulating apparatus to be temperature-regulated comprise one or more features of the above-mentioned accommodating chamber.
  • All of the above independent temperature-regulating devices can comprise, individually or in combination, one or more of the embodiments mentioned below, in particula r an inputting means which is capable of detecting an insertion of a medicament container to be temperature-regulated into a chamber to be temperature-regulated, and, depending thereon, to control the required temperature regulation .
  • a temperature-regulating device denotes a means for cooling and/or heating the accommodating chamber(s) .
  • the temperature-regulating device preferably comprises a thermoelectric element that is suitable both for cooling as well as for heating .
  • Thermoelectric elements, in particular micro- Peltier elements are advantageous in that a quick and precise temperature regulation is possible primarily using small components .
  • An inputting means substantia lly includes all means with which an insertion of a medicament container or an immediately imminent insertion can be registered .
  • the inputting means comprises a micro switch, a capacitive, an inductive and/or a n optica l sensor. This can be effected, for example, by means of tactile/haptic, acoustical and optical inputting means .
  • Sensors which, disposed in the accommodating chamber, detect an insertion of a medicament container are possible tactile inputting means .
  • optical or acoustical sensors that automatically detect an insertion are a lso suitable.
  • a user actively registers the insertion of a medicament container by means of the inputting means, thus activating the temperature regulation of an accommodating chamber.
  • tactile sensors in the form of keys or optical sensors such as scanners or detectors are conceivable which are able to register the intention of the user of inserting a medicament container, and thus of temperature regulation .
  • a user may hold a medicament container in front of an, in particular, optical detector. The detector registers the med icament container and/or a printed label on the medicament container and as a consequence of this detection activates the temperature regulation of an accommodating chamber suitable for this pur- pose.
  • the detector registers information on the temperature that is to be provided for the med icament in the medicament container.
  • the user then inserts the medicament conta iner into the accommodating chamber.
  • the temperature-regulating apparatus makes it possible that the temperature-regulating device can be specifically activated at the required or at least at a particularly suitable point in time, depending on whether a medica ment container was inserted into the accommodating chamber and/or whether such an intention was registered by the user, i .e. basically that such an insertion is immediately imminent.
  • the energy consumption of the temperature-regulating apparatus can thus be reduced a nd accordingly, a battery or a rechargeable battery can thus be given smaller dimensions .
  • the temperature regulation of a n accommodating cha mber is deactivated accordingly in one embodiment of the invention when a medicament container is removed, with the inputting means being configured such that it is capa ble of registering a removal and/or the intention of a removal by the user. Unnecessary temperature regulation following a removal and an associated energy consumption of one or more unused accommodating chambers is thereby avoided .
  • a battery or rechargeable battery can be given appropriately small d imensions, whereby the temperature- regulating apparatus can be configured to be even smaller and/or an even longer service life and longer operating times can be achieved .
  • the accommodating chamber that is, the inner walls surrounding the cavity of the accommodating cha mber, is positively adapted to the medicament container.
  • the distance that results between the cavity and the accommodated medicament container is no greater than 4.9 millimeters, particularly preferably no greater than 1 . 1 mm, particularly prefera bly no greater than 0.9 mm . This ensures that the accommodating chamber accommodates the medicament container in a space-saving manner. The volume to be temperature-regulated in the accommodating chamber is thus reduced because the medicament container almost completely fills the cavity in the accommodating chamber.
  • the temperature-regulating device requires less energy for the temperature regulation of the accommodating chamber, which a lso leads TO a temperature-regulating a pparatus with smaller dimensions and/or to a longer service life and operating time. At the same time, a quick temperature regulation to the desired temperature can thus be achieved .
  • the additional feature of this embodiment constitutes an independent invention, in particular independent from the inputting means .
  • the length and/or the width and/or the depth and/or the d iameter of the accommodating chamber corresponds to the length and/or the width and/or the depth and/or the diameter of the medicament container.
  • this a lso ensures that the accommodating chamber accommodates the medicament container in a space-saving manner.
  • the volume to be temperature-regulated in the accommodating chamber is thus reduced because the med icament container almost com- pletely fills the cavity in the accommodating chamber.
  • the temperature-regulating device requires less energy for the temperature regulation of the accommodating chamber, which also leads to a temperature-regulating apparatus with smaller dimensions and/or to a longer service life and operating time. At the same time, a quick temperature regulation to the desired temperature can thus be achieved .
  • the additional feature of this embodiment is capable also of independently achieving the object, in particular independent from the inputting means .
  • the accommodating chamber inside, has a length of 99 mm to 1 1 1 mm, prefera bly to 1 06 mm, particularly preferably to 1 03 mm, a width of 79 to 91 mm, preferably to 96 mm, particularly preferably to 93 and/or a depth or height of 1 9 mm to 31 mm, preferably 26 mm, particularly preferably to 23 mm .
  • An accommodating chamber thus dimensioned is adapted to the typical dimensions of a set of insulin-containing refill car- fridges. Such a set typically is 1 00 mm long, 20 mm high or deep, and 80 mm wide.
  • an accommodating chamber serving as an administering chamber which is 1 69 mm to 1 81 mm, preferably ⁇ o 1 75.5 mm, particularly preferably to 1 72.5 mm in length, which is 1 9 mm to 31 mm, preferably to 26 mm, particularly preferably to 23 mm in width and/or depth, or which has a diameter of 1 9 mm to 31 mm, preferably to 26 mm, particularly preferably to 23 mm .
  • Such an administering chamber is provided for a pen which is 1 70 mm in length and 20 m m in diameter, with which a medicament can be injected .
  • an accommodating chamber serving as an administering chamber which is 1 59 mm to 1 71 mm, pref- erably to 1 66 mm, particularly prefera bly to 1 63 mm in length, which is 1 9 mm to 3 1 mm, preferably to 26 mm, particularly preferably to 23 mm in width and/or depth, or which has a diameter of 1 9 mm to 31 mm, preferably to 26 mm, particularly preferably to 23 mm .
  • Such an administering chamber is provided for a pen which is 1 60 mm in length and 20 mm in di- ameter, with which a medicament can be injected .
  • the medicament containers can have different shapes, such as, for exa mple, pen sticks, ampoules or vials .
  • the temperature-regulating apparatus includes different accommodating chambers for different shapes of medicament containers .
  • d ifferent medicaments can be stored and transported in the temperature-regulating apparatus .
  • the differently dimensioned accommodating chambers can be disposed in such a way that a n energy-efficient temperature regulation by the temperature-regulating device is possible.
  • the temperature-regulating device is configured such that individual accommodating chambers can be temperature-regulated differently. For example, this enables a temperature regulation of individual accommodating chambers to different temperatures, which are usually storage temperatures of between 2-8°C .
  • the medica ments can thus be temperature-regulated individually to the respective optimum temperature. This is advantageous in particular with regard to the efficacy and/or storage life of the respective medicaments .
  • an accommodating chamber is furthermore provided which temperature-regulates the accommodated medicament to an administering temperature.
  • the administering temperature of medicaments as a rule is in the range of 1 5-25°C .
  • this ac- commodating chamber which is provided as an administering chamber, is provided additionally and/or so as to be thermally insulated .
  • the user places the medicament into it prior to its application, so that the medicament can be temperature- regulated to the correct administering temperature.
  • An inputting means in the form of a sensor for example in the form of a micro switch, an optical sensor, a capacitive sensor or an inductive sensor, can register an insertion, for example, and temperature-regulate the administering chamber to the appropriate temperature.
  • a sensor for example in the form of a micro switch, an optical sensor, a capacitive sensor or an inductive sensor, can register an insertion, for example, and temperature-regulate the administering chamber to the appropriate temperature.
  • no additional administering chamber is provided and that the accommodating chamber is temperature-regulated to an administering temperature after the user has registered via an inputting means the intention of an administration .
  • What is advantageous about an additional and/or thermally insulated administering chamber is that a quick temperature regulation to an administering temperature is possible due to a difference which as a rule exists between the stor- age temperature and the administering temperature of a medicament.
  • Providing a second accommodating chamber serving as an administering chamber is advantageous in particular if the first accommodating chamber is configured and dimensioned such that it serves for accommodating a plurality of medicament containers designed as refill cartridges. If required, a first refill cartridge is taken from the first accommodating chamber and inserted into a stick pen. The stick pen is then transferred into the second accommodating chamber.
  • the first accommodating chamber is temperature-regulated in accordance with the prescribed storage temperature of the medicament.
  • the second storage chamber is temperature-regulated in accordance with the prescribed administering temperature while the stick pen or medicament container is inserted.
  • the temperature- regulating apparatus comprises a control device, in particular a micropro- cessor control unit, which is configured such that the temperature-regulating device regulates the temperature efficiently and/or that the selection of the accommodating chamber enables an efficient temperature regulation.
  • a control device in particular a micropro- cessor control unit, which is configured such that the temperature-regulating device regulates the temperature efficiently and/or that the selection of the accommodating chamber enables an efficient temperature regulation.
  • the control device allocates the appropriate and energetically efficient accommodating chamber after the storage temperature has been detected, for example by a scanner. In particular, this makes an improved service life and operating time of the temperature-regulating apparatus possible.
  • the temperature-regulating apparatus comprises at least one outputting means for information for intuitive user guidance.
  • the outputting means can usually be realized in an optical or acoustical manner.
  • a touch panel which in addition to an optical outputting means also comprises a tactile/haptic inputting means, can be provided, on which user information can be displayed.
  • User information may include, for example, information read in about medicaments such as storage temperature, administering temperature and storage life.
  • displays for visual signaling in particular regarding the condition of the accommodating chambers, and/or loudspeakers for acoustical signa ling can be provided .
  • Small displays on the accommodating chamber can, for example, d isplay the temperature and/or the occupancy of the accommodating chamber.
  • the outputting means enable an improved user guida nce and moreover prevent or reduce possible operating errors by the user.
  • the user can be guided with regard to an energy- efficient and safe use of the temperature-regulating apparatus .
  • At least one input device for acquiring information is provided .
  • An input device substa ntially comprises sensors or data acquisition devices . It is possible to provide tactile/haptic, acoustical and optical input devices on the temperature-regulating appa- ratus . User inputs and/or information on the medicament can be acquired by means of the input device. Using the a bove-mentioned touch panel, for example, the user is a ble to input information directly.
  • information which is usually located as a machine- readable code on the medicament container can be read automatically by means of an optical input device, such as a scanner.
  • the information read in may include, among other things, the storage temperature, ad ministering temperature, type of medicament, constructional shape of the medicament container and/or other important information for the user.
  • the control device can then process the information received via the input device, and in pa rticular regulate the temperature of the respective accommodating chamber accordingly. This makes an intuitive interaction possible between the user and the temperature-regulating apparatus .
  • information about the medicament can be quickly read in by means of optical input devices, such as scanners, which enables a comfortable and safe use of the temperature- regulating apparatus .
  • the input device enables an energy-efficient temperature regulation of the accommodating chambers .
  • a medicament is first read in by means of an input device, such as, for example, a ba r-code scanner.
  • the control device selects a suitable accommodating chamber a nd displays it to the user via an outputting means, such as an LED display.
  • this accommodating chamber can then also be temperature-regulated .
  • the medica ment is inserted, which is registered by a n inputting means such as a detector, the temperature reg ulation to the read-in storage temperature and/or administering temperature begins at the latest.
  • a weight sensor is provided on an accommodating chamber which is capa ble of detecting the weight of the accommodated medicament. This can be used additionally for checking the accommodated medicament in order to avoid mix-ups or to visually or acoustically signal, by means of an appropriate outputting means, such as an LED display or a loudspeaker, mix-ups that have occurred . This check is possible by comparing the determined weight with a prescribed weight which was read in, for example, via the input device.
  • the weight sensor is additiona lly used for determining when there is no me- dicament in the accommodating chamber anymore.
  • the further temperature regulation of the accommodating cha mber is stopped in order thus to minimize energy consumption .
  • the further temperature regulation is stopped with a delay in time, for example not until it is determined by means of the weight sensor or another sensor that no medicament was located in the accommodating chamber for a period of, for example, at least 30 seconds or at least one minute.
  • This embodiment is pa rticularly suitable if a plurality of medicament containers that are packaged, for example, in a blister pack, is to be stored in the stor- ing chamber.
  • the blister pack is first taken out in its entirety from the accommodating chamber, a medicament container is removed from the blister pack, and the blister pack with the remaining medicament containers is then reinserted into the accommodating cha mber, which must then be temperature-regulated further. It is not imperative that a weight sensor is provided in this embodiment.
  • a different detector which is able to detect the presence of a medicament in the accommodating chamber is sufficient, such as, for example, an appropriate optical detector which is capable of this .
  • a temperature sensor by means of which the temperature in the accommodating chamber can be determined, is mounted on or in the accommodating chamber. By determining the actua l temperature in the accommodating chamber, the intended temperature can be set exactly by means of the control device, which makes a precise temperature regulation possible.
  • another embodiment provides to secure one or more accommodating chambers with a locking means .
  • the locking means is capa ble of preventing accommodating chambers from opening inadvertently.
  • erroneous application of medicaments and/or incorrect storage can be prevented by an electrically controlled locking and unlocking of individual accommodating chambers .
  • the control device is configured such that after a medica- ment has been read in by means of an optical input device, an appropriate accommodating chamber is indicated to the user preferably by means of a display, and this accommodating chamber is promptly unlocked for insertion . After a correct insertion, the accommodating cha mber concerned is relocked . Unlocking for removing the medicament accordingly takes place not until a release is effected by the control device, which can preferably be triggered by the user.
  • the chamber walls are prefera bly fabricated from a metal, in particular from aluminum, in order to keep the weight low. Cooling ribs ca n be provided in order to dissipate heat thereby.
  • the heat that is withdrawn during a cooling process is used for melting a substance, such as a salt, in order to be able to quickly dissipate large quantities of heat without having to provide a la rge volume for this purpose.
  • a fan can be dispensed with in this case. Heat is withdrawn from an accommodating chamber in particula r by means of a thermoelectric element and is supplied to the substance to be melted .
  • the temperature- regulating apparatus comprises at least one communication means for data .
  • a communication means is capable of establishing a connection between communication devices . Communication can be established by means of a mechanical connection, such as cables, or preferably wireless- ly. In addition to data excha nge, a cable-bound connection, such as, for example, a USB interface usually also makes it possible to charge a rechargeable battery. I n addition to wi-fi, the Bluetooth system is also suitable where wireless connections are concerned .
  • the communication means for data exchange enables a simple transfer of user data between the commu- nication devices .
  • a communication means for an identification of communication devices is provided .
  • a wireless identification such as in the case of the F ID system, is adva ntageous .
  • the comm unication means on the temperature-regulating apparatus then recognizes wirelessly the associated communication device, which is located, in partic- ular, in the vicinity of the temperature-regulating apparatus .
  • the communication device such as an RF ID transponder, can be identified for a certain user, and the control device can release the medicament to the identified user.
  • the control device then manages the data of the in- dividual users and their medicaments in the temperature-regulating apparatus .
  • This embodiment is suitable, in particular, for use in hospitals .
  • a patient is identified by means of the communication system, and the administration of the medicament intended for this patient is controlled and/or signaled by the temperature-regulating a pparatus .
  • the communication means is configured such that it is capable of transmitting user messages such as warnings, alarms or information .
  • a warning or alarm can thus be transmitted, for example via mobile telephone service, such as, for instance, by means of SMS.
  • the user can then be notified by means of a voice message or a text message that a medicament is ready for administration .
  • the temperature-regulating apparatus is thus capa ble of ensuring regular application of the medicaments and warn or remind the user if necessary.
  • the temperature- regulating apparatus has a modular configuration .
  • the modula rity makes it possible that the temperature-regulating appa ratus is assembled from standardized components . Therefore, the temperature-regulating a pparatus is capable of being extended in a flexible manner.
  • the standardized components are not only limited to components that provide separate functions, such as, for example, a communication module for Bluetooth, but include modules that enable a flexible extension with at least one accommodating chamber.
  • the extension of the accommodating chamber can be realized mechanically, by means of a connecting means such as a clamping, rota ry and/or press-on closure, whereby a quick connection of several modules is made possible.
  • a master module is provided which primarily comprises the control device.
  • This master module can be flexibly combined by means of other modules with one or more accommodating chambers and different sizes . It is thus possible to manage several modules using a single master module.
  • the temperature-regulating apparatus is capable of managing several users and their accommodated medicaments by means of a single master module. I n particular, it is possible in this embodiment to replace accommodating chambers in order to be able to change the chamber volume if required .
  • the temperature-regulating apparatus can also serve for the temperature regulation of, for example, organs in the case of an organ transport.
  • a suitably dimensioned accommodating chamber can be added or provided easily in particular in the case of a modular structure.
  • the temperature-regulating apparatus in a preferred embodiment of the invention, is produced by laser-sintering plastic .
  • Thermal threads that is, hollow threads, are preferably incorporated into the housing of the temperature-regulating apparatus for improved thermal insulation . At particularly important areas of the housing, they can provide for the passage of thermal energy being reduced .
  • the temperature-regulating device comprises a locating device, which comprises a GPS system, for instance.
  • a locating device which comprises a GPS system, for instance.
  • the location of the temperature-regulating device during transport ca n by determined by means of the locating device, in order thus to be able, for example, to find a user quickly.
  • the temperature-regulating device comprises a wireless communication module, such as wi-fi or a mobile telephone connection such as UMTS for external control of the temperature-regulating apparatus .
  • a wireless communication module such as wi-fi or a mobile telephone connection such as UMTS for external control of the temperature-regulating apparatus .
  • parameters of the temperature-regulating apparatus can be changed wirelessly, or preferably, a software program can be updated a utomatically.
  • a temperature-regulating device can comprise a lid which is pivotably connected to the accommodat- ing chamber, in order to be able to close the accommodating chamber.
  • a fastening means in the accommodating chamber which can be connected to the medicament container, can also be configured to be pivotable in order to be able to pivot the fastening means into a suitable position for fastening the medicament container. Subsequent to fastening the medicament container, the medicament conta iner and the fastening means can be pivoted in such a way that the medicament conta iner arrives in the accommodating chamber and that the latter can be closed by a lid or a cap .
  • Figure 1 shows a temperature-regulating a pparatus
  • Figure 2 shows another embodiment of the temperature-regulating apparatus
  • Figure 3 shows another embodiment of the temperature-regulating appa- ratus
  • a temperature-regulating apparatus 1 is outlined in F igure 1 .
  • the temperature-regulating apparatus 1 comprises a housing 2 with several accommodating cha mbers 3.
  • the accommodating chambers 3 are configured so as to be lockable.
  • the accommodating chamber can be opened via an unlocking means 7 in the lid of the accommodating chamber 3, provided it was unlocked appropriately in order to enable the removal of the medicament.
  • the status of an accommodating chamber is indicated by several LED status displays 5.
  • the LED displays 5 are capable of showing the status of the accommodating chamber by means of different colors or a flashing cycle.
  • the user is able to see, without opening the accommodating chambers 3, which accommodating cha mbers are currently being temperature-regulated .
  • temperature displays 4 are also provided on accommodating chambers 3 so that the user is able to directly read off the temperature.
  • Accommodating chambers 3 of different sizes are provided for accommodating different medicament containers .
  • accommodating chambers for several ampoules or other medicament containers are also disposed on the tempera- ⁇ ure-regula ⁇ ing apparatus 1 in a space-saving manner.
  • the accommodating chambers 3 are labeled in Braille 6.
  • FIG. 2 Another embodiment with an accommodating chamber 3 is shown in Figure 2.
  • This embodiment comprises a touch screen 8 for displaying relevant user information and for inputs.
  • Information for example on the operative condition or concerning operation, can be outputted acoustically by means of a loudspeaker 9.
  • a micro-bar-code scanner 10 serves as an inputting means in order to be able to read in machine-readable information on a medicament package and starting a temperature regulation of the accommodating chamber 3 dependent thereon.
  • a rechargeable battery of the temperature-regulating apparatus can be charged and/or data can be exchanged with a computer via a port, such as, for example, a USB port 15.
  • An indicator light 11 serves as a temperature indicator, for example in order to signal by means of a green light that a predetermined temperature in the accommodating chamber 3 has been reached.
  • Another indicator light 12 signals the operative condition of the rechargeable battery. If, for example, this light is lighted green, the rechargeable battery is sufficiently charged. Yellow, for example, signals a necessity for charging. Red signals that the rechargeable battery is almost completely discharged.
  • An indicator light 13 signals the correct connection of a power supply unit.
  • a light sensor 14 regulates the brightness of the respective visual displays in order thus to minimize power consumption.
  • a plurality of other ports 15, such as, for example, USB ports, can be provided, for example in order to connect other modules to the module shown in Figure 2.
  • An indicator light 16 shows the operative condition of a Bluetooth communication device 17.
  • An indicator light 18 shows the operative condition of a wi-fi communication device 19.
  • the temperature-regulating apparatus 1 shown in Figure 2 comprises an RFID transmitter and/or receiver 20.
  • a desired temperature in the accommodating chamber 3 can be set manually using keys 21 and 22.
  • a temperature-regulating apparatus can, for example, comprise a module which in addition to one or more rechargeable batteries comprises, for exa mple, a computer unit that is connected, for example, with the embodiment shown in Figure 1 or F igure 2.
  • Another mod ule can be an ac- commodating chamber, which can be provided with its own display devices and the like.
  • the temperature-regulating appa ratus, or a module of the temperature-regulating apparatus can comprise an emergency key in order to be able to initiate an emergency call via mobile phone service. At the same time, an emergency call initiated in this manner expediently compris- es information regarding the location of the temperature-regulating apparatus .
  • the temperature-regulating apparatus expediently comprises an on/off switch .
  • FIG 3 shows another embodiment of a temperature-regulating apparatus which comprises a cylindrical accommodating chamber consisting of a container 30 and a ca p 31 .
  • the cap 31 can be firmly connected to the container 30, for example through a screwed connection or a latching connection .
  • the cap 31 preferably consists of plastic and, moreover, is equipped with thermally insulating layers and/or materials, such as, for example, foamed materials .
  • thermoelectric elements 32 are disposed in the area that is shown in dashed lines .
  • the area 32 is dimensioned in such a way that it is adjacent to the area of the medicament container containing the medicament.
  • a control apparatus can be provided which controls the temperature regulation by the thermoelectric elements depend ing on the position of a piston of the medicament container, in such a way that only that area is heated which comprises the medicament.
  • a medicament container 33 which extends into the cap 31 is located within the accommodating chamber. If the cap 31 is removed, then the medicament container protrudes from the rest of the area 30 of the accommodating chamber. The medicament container 33 can then be grasped easily and pulled out from the rest of the area 30 of the accommodating chamber.
  • a flat area with a rectangular surface, which comprises a display 35, is attached to the side of the accommodating chamber 30, 31.
  • the temperature-regulating apparatus shown in Figure 3 is placed on a desk in such a way that the display 35 is visible, then this display is situated on the surface of the desk in a slightly inclined position, and is thus easily readable.
  • the rectangular area 34 can accommodate further components of the temperature-regulating device.
  • the medicament container 33 is connected to a fastening de- vice 36 by, for example, a thread, i.e. by screwing.
  • the cap 31 is preferably capable of closing the container 30 only when the medicament container 33 is fully connected to the fastening device 36.
  • the fastening device 36 comprises a sensor 37, for example a micro switch or other sensor, with which it is possible to determine whether a medicament container 33 was properly connected to the fastening means 36. However, this sensor may also be omitted if the container 30 can only be closed with the cap 31 if the medicament container 33 has been properly fastened to the fastening means 36. In that case, a sensor or detector is sufficient which is capable of determining whether a medicament container 33 is located in the container 30.
  • a sensor 38 for example a micro switch
  • a sensor 38 it is possible to determine by a sensor 38, for example a micro switch, whether the container 30 was properly closed with the cap 31.
  • a micro switch as a sensor is advantageous in that it does not consume energy, in contrast to other sensors, such as, for example, optical sensors, which can prolong operating life.
  • an insert can be disposed, which is not shown and which consists, in particular, of metal or at least partially of metal, and which preferably protrudes from the container 30 and in that case can be easily removed and replaced with a different insert.
  • the medicament container 33 is located wholly or partially within the insert.
  • the accommodating chamber 30, 31 can be enveloped at least partially by layers that comprise substances that are brought from a liquid state into a solid state by a supply of heat.
  • layers that comprise substances that are brought from a liquid state into a solid state by a supply of heat.
  • the substance in an inner layer is brought into the solid state at a lower temperature, in pa rticular at temperatures between 2°C and 8°C, compared to the substance in the, relative thereto, outer layer.
  • the substance of the outer layer is preferably brought into the solid state at a temperature of between 20°C and 30°C .
  • the insulation in the form of one or more such layers can be combined with every one of the embodiments or independent inventions disclosed in this document.
  • the container 30 is configured in such a way that it is capable of accommodating, in addition to a medicament container, one or more refill cartridges for the medicament container, or one or more further medicament containers .
  • the different chambers can be interconnected via supply ducts in order to allow for a thermal equalization between the chambers .
  • Figure 4 shows a section of a possible design of the cha mber 30.
  • a plurality of chambers 39 are grouped around a main climate cha mber 40.
  • ducts 41 optionally lead to the cha mbers 39 in a star-shaped manner.
  • An exchange of air is possible between the various chambers 39, 40 via the ducts 41 .
  • At least one refill cartridge ca n be pushed into each chamber 39.
  • all the chambers 39 and 40 can be closed by a single cap, as shown in Figure 3.
  • the two caps can be provided at opposite ends of a, for example, cylindrical container 30.
  • the remova l of the cap for the main climate chamber 41 prevents the opening process for removing an already used medicament container from causing warm air to be able to flow directly a lso into the chambers 39, which would increase energy consumption .
  • thermoelectric elements are arranged in such a way that primarily the main climate chamber 40 is tern- perature-regulated by them.
  • the temperature regulation of the further chambers 39 is then effected by an exchange of air through the ducts 41.
  • there are exactly five chambers 39 for refill cartridges because this number was found to be particularly suitable in order to be able to be disposed around a main climate chamber 40 while taking into account the various requirements.
  • at least one spring is provided in each of the one or more chambers 39, which springs are biased when refill cartridges are located in these chambers 39.
  • the refill cartridges are then immovably located in these chambers 39.
  • a fastening mecha- nism can in that case be provided in each chamber 39, with which refill cartridges can or must be fastened in each chamber 39 in order to be able to close each chamber 39.
  • several chambers 39 are shut with a rotatable plate with a passage. If the plate is rotated in a suitable manner, access to one of the chambers 39 is provided via the passage. It is thus avoided that, in case of need, all the chambers 39 have to be opened at the same time which would increase energy consumption accordingly.
  • the plate can be pressed against the openings of the chambers 39 by a biased spring. Springs located in the chambers 39 can be used so that an end of a refill cartridge is pushed out if the corresponding chamber is opened.
  • the invention is particularly suitable for the temperature regulation of insulin. List of Reference Symbols
  • thermoelectric elements 32 Area for thermoelectric elements

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  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Thermal Sciences (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)

Abstract

L'invention concerne un appareil portable de régulation thermique de médicaments sous forme solide ou liquide. Un appareil de régulation thermique selon l'invention comprend un boîtier comportant au moins une chambre de réception, au moins un dispositif de régulation thermique pour réguler la température de la chambre de réception, en particulier un dispositif de régulation thermique thermoélectrique, au moins un moyen d'entrée apte à enregistrer une introduction d'un contenant de médicament dans la chambre de réception ou une introduction immédiatement imminente, et de commander la régulation thermique de la chambre de réception en fonction de celui-ci.
EP12740141.2A 2011-07-27 2012-07-26 Dispositif portable de temperature réglable pour médicaments Active EP2736477B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102011079908A DE102011079908A1 (de) 2011-07-27 2011-07-27 Tragbare Temperiervorrichtung für Medikamente
PCT/EP2012/064647 WO2013014219A1 (fr) 2011-07-27 2012-07-26 Appareil portable de régulation thermique pour médicaments

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EP2736477A1 true EP2736477A1 (fr) 2014-06-04
EP2736477B1 EP2736477B1 (fr) 2016-04-13

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EP (1) EP2736477B1 (fr)
JP (1) JP6215824B2 (fr)
CN (1) CN103889389B (fr)
AU (1) AU2012288857B2 (fr)
BR (1) BR112014001811A2 (fr)
CA (1) CA2843117A1 (fr)
DE (1) DE102011079908A1 (fr)
DK (1) DK2736477T3 (fr)
ES (1) ES2574258T3 (fr)
HK (1) HK1193560A1 (fr)
HU (1) HUE027983T2 (fr)
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Also Published As

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WO2013014219A1 (fr) 2013-01-31
AU2012288857A1 (en) 2014-02-20
MX2014001055A (es) 2014-09-25
CN103889389A (zh) 2014-06-25
JP6215824B2 (ja) 2017-10-18
US20140230454A1 (en) 2014-08-21
MY163340A (en) 2017-09-15
EP2736477B1 (fr) 2016-04-13
RU2610763C2 (ru) 2017-02-15
PL2736477T3 (pl) 2016-10-31
ES2574258T3 (es) 2016-06-16
MX343162B (es) 2016-10-26
TW201312067A (zh) 2013-03-16
JP2014521424A (ja) 2014-08-28
DK2736477T3 (da) 2016-06-06
HUE027983T2 (en) 2016-11-28
BR112014001811A2 (pt) 2017-02-21
PT2736477E (pt) 2016-06-03
HK1193560A1 (zh) 2014-09-26
CA2843117A1 (fr) 2013-01-31
AU2012288857B2 (en) 2016-03-17
RU2014104768A (ru) 2015-09-10
US10071019B2 (en) 2018-09-11
CN103889389B (zh) 2016-06-08
DE102011079908A1 (de) 2013-01-31
TWI550243B (zh) 2016-09-21

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