EP2688650A1

EP2688650A1 - Film-forming composition containing a sun filter, and use thereof for the treatment of scars

Info

Publication number: EP2688650A1
Application number: EP12717361.5A
Authority: EP
Inventors: Nathalie DERAIN
Original assignee: Laboratoires Urgo SAS
Current assignee: Urgo Recherche Innovation et Developpement
Priority date: 2011-03-25
Filing date: 2012-03-23
Publication date: 2014-01-29
Also published as: SG193570A1; BR112013024025A8; CN103517738A; ZA201307335B; BR112013024025A2; FR2972923B1; RU2586293C2; CN103517738B; KR20140007922A; FR2972923A1; JP2014508797A; US20140127148A1; WO2012131237A1; AU2012236013A1; RU2013147620A; MX2013011055A; CA2830459A1

Abstract

The invention relates to a fluid composition containing at least a polymer, a plasticiser, a volatile solvent, and a very small amount of an organic sun filter in the order of between 0.5 and 2.2 wt.-% in relation to the total weight of the composition. The composition, which is intended to be applied to the skin, can be used to treat scars. In addition, the composition advantageously contains a derivative of dibenzoylmethane and a cinnamate derivative.

Description

Film-forming composition containing a sunscreen, its use for the treatment of scars

The present invention relates to a liquid dressing containing at least one polymer, a plasticizer, a volatile solvent, and an organic solar filter in a very small amount. This composition, intended to be applied to the skin to cover it with a waterproof film, can be advantageously used for the treatment of scars.

Scars are particularly fragile and sensitive not only to external pathogens, but also to ultraviolet (UV) radiation from the sun.

Several products have already been commercially available for the protection of scars, especially with regard to UV radiation. Some of them are in the form of emulsion creams and contain a large amount of water. These water-based products include very high levels of sunscreens to ensure sufficient efficacy against UV radiation (of the order of 10 to 35% by weight).

A cream for reducing scars containing from 2 to 7.5% by weight of Octinoxate and from 0.5 to 7.5% by weight of zinc oxide has been described in US Pat. No. 7,241,451. however, has the disadvantage of having poor water resistance, so that the sun protection of the scar disappears as soon as the skin is brought into contact with water. In addition, this type of cream has the disadvantage of not withstanding friction.

Moreover, a certain proportion of the sunscreens that these formulations contain tend to penetrate the skin, so that to ensure effective protection of the skin against UV radiation, the composition must contain a high proportion of organic filter (s). (s).

Liquid dressings formulated in a volatile solvent are generally in the form of a fluid that is applied to the skin via a suitable applicator, such as a spray, a brush, a spatula or a pallet. The volatile solvent evaporates on contact with the skin to leave a solid film that protects the skin.

The liquid dressings forming a film on the skin have the advantage of limiting the penetration of the constituents into the skin since the film formed is solid and remains on the surface. In addition, these films being water resistant and rubbing, it is possible to keep them several days after their application.

It has been proposed in document FR 2 929 522, a liquid dressing in the solvent phase containing organic sunscreens and inorganic sunscreens in large amounts. However, the Applicant has found that the inorganic filters decant with time, so that the composition is not stable during storage.

In addition, contrary to the teaching of this document, the Applicant has shown that it is not necessary to incorporate an inorganic sunscreen to obtain effective protection against UV. The Applicant has thus optimized the nature and the amount of sunscreen to be incorporated in a liquid dressing in the solvent phase.

The Applicant has also discovered, against all odds, that the organic filter ButylMethoxydibenzoylmethane (Avobenzone) retains, in this type of formulation, a high solar protection power even after irradiation, so that it is not necessary to add a light stabilizer, such as Octocrylene conventionally used in combination therewith.

The present invention thus provides liquid dressings with satisfactory absorption in the UV using a limited amount of solar filter (s), preferably organic (s).

The present invention therefore relates to a fluid composition intended to be applied to the skin containing a polymer, a plasticizer, a solvent of said polymer, excluding water which is volatile, and at least one organic sunscreen, characterized in that the total content of solar filter (s) is between 0.5 and 2.2% by weight of the total weight of the composition, the volatile solvent represents from 60 to 90% by weight relative to the total weight of the composition, and the polymer represents from 5 to 20% by dry weight of the total weight of the composition.

The polymer is preferably capable of forming a continuous film on the skin, after application of the composition according to the invention. The polymer is preferably insoluble in water and forms a water insoluble film once the volatile solvent of the evaporated composition. For example, hydroxypropylcellulose and hydroxyethylcellulose do not form water insoluble dry films. The polymer is preferably soluble in a volatile solvent other than water. The polymer may be chosen from polymers of natural origin, guar gums, gum arabic, alginates, xanthan gum, gelatin, chitosan, silicates, hydrous silicas, polyurethanes, polyesters, polyesters amides, polyamides, polyureas, vinyl polymers, acrylic polymers, polyvinylbutyrals, alkyd resins, resins derived from aldehyde condensation products such as arylsulfonamide formaldehyde resins, epoxy aryl-sulfonamide resins, resins ethyltosylamide, acetophenone / formaldehyde resins, and mixtures thereof.

The vinyl polymers may result from the homopolymerization or copolymerization of monomers selected from vinyl esters such as vinyl acetate, vinyl neodecanoate, vinyl pivalate, vinyl benzoate and vinyl t-butyl benzoate and styrenic monomers such as styrene and alpha-methyl styrene.

The acrylic polymers may be homopolymers of acrylic acid, copolymers of acrylic acid, homopolymers of methacrylic acid or copolymers of methacrylic acid.

According to one embodiment, the polymer is chosen from cellulose polymers, especially hydroxypropylmethylcellulose, cellulose ethers, cellulose esters, nitrocellulose, water-insoluble cellulose derivatives, and mixtures thereof.

According to one embodiment, the polymer is a nitrocellulose, preferably chosen from nitrocelluloses of high viscosity. It will be possible to use nitrocellulose of quality between RS 1/2 second and RS 20 seconds according to the American standard, corresponding to a quality between 8E and 21E according to the European standard. For example, nitrocellulose grade 10E or 11E (RS 15 seconds according to the American standard) is preferred.

The nitrocellulose may be chosen in particular from nitrocellulose RS 5 sec. and RS 15 sec. sold by the company HERCULES, the products DHL ^® 120/170, DHL ^® 25/45 or DHX ^® 40/70 marketed by Nobel Enterprises, the nitrocellulose E 840 ^® and E 620 ^® produced by Wolff Cellulosics, and the products marketed under the E80 ^® , E70 ^® , E60 ^® and E40 ^{® references} by SNPE - Bergerac. The nitrocellulose may be provided in dry form or in solution in a solvent such as isopropanol or ethanol. The polymer is preferably present in a content ranging from 5 to 20% by dry weight of the total weight of the composition, for example from 6 to 15% or even from 6 to 9% by dry weight, relative to the total weight of the composition.

The plasticizer makes it possible to soften the film; it is advantageously chosen from oils of vegetable origin and their oxyethylenated derivatives. Vegetable oil can be:

The vegetable oil is advantageously chosen from sesame oil, castor oil, almond oil, canola oil, hazelnut oil, pistachio oil and linseed oil. , borage oil, hemp seed oil, jojoba oil, sunflower oil, wheat germ oil, corn oil and / or corn germ, peanut, avocado oil, safflower oil, rapeseed oil, olive oil, argan oil, sunflower oil, grape seed oil, soybean oil, walnut oil, pumpkin seed oil, palm oil, coconut oil, and mixtures thereof.

The oil can also be a derivative of one of the vegetable oils mentioned above. It may be hydrogenated oil or not, peroxidized or not.

It is also possible to choose the plasticizer from:

monocarboxylic acid esters such as isononyl isononanoate, oleyl erucate or octyl-2-dodecyl neopentanoate;

fatty alcohols such as octyldodecanol, 2-butyloctanol, 2-hexyl decanol, 2-undecylpentadecanol, oleyl alcohol;

fatty acids such as oleic acid, linoleic acid, linolenic acid;

glycols and their derivatives, such as diethylene glycol ethyl ether, diethylene glycol methyl ether, polyethylene glycols, polypropylene glycols;

dicarboxylic acid esters, such as citrates (acetyl tributyl citrate), phthalates (dibutyl phthalate), adipates, sebacates (dibutyl sebacate);

triacetin or glyceryl triacetate;

glycerine;

- their mixtures.

The plasticizer is preferably soluble in the polymer solvent.

Advantageously, the plasticizer and the polymer are present in the composition according to the invention in a weight ratio ranging from 0.5 to 1.5, and better still ranging from 0.7 to 1.2, more particularly close to 1.

In the context of the present invention, the term organic sunscreen means any organic compound absorbing UV radiation in the wavelength range generally from 280 nm to 400 nm. The solar filter S

organic compound used according to the invention can be a compound filtering UV-A radiation with wavelengths between 320 and 400 nm, a compound filtering UV-B radiation with wavelengths between 280 and 320 nm, a compound filtering UV-A and UV-B radiation or a mixture thereof.

The composition preferably comprises less than 0.5%, more preferably less than 0.2% by weight of inorganic solar filter (s) relative to the total weight of the composition.

The composition of the invention is preferably free of inorganic sunscreen.

The total amount of solar filter (s) in the composition is low, preferably between 0.5 and 2.2%, more preferably between 1.2 and 1.8%, preferably 1.5% by weight relative to the total weight of the composition.

The organic filter may be chosen from active organic screening agents in UV-A, organic active filters in UV-B, active organic screening agents in UV-A and UV-B, and mixtures thereof.

An active organic screening agent in the UV-A is advantageously chosen from: dibenzoylmethane derivatives, such as butyl methoxydibenzoylmethane (INCI name) or Azobenzone (USAN name) sold especially under the trade name PARSOL ^® 1789, or risopropylDibenzoylmethane,

- the menthylanthranilate sold especially under the reference Neo Heliopan ^® MA by Symrise,

- their mixtures.

The composition of the invention advantageously contains a derivative of dibenzoylmethane without adding a light stabilizing agent, such as Octocrylene. According to one embodiment, the dibenzoylmethane derivative is added a liposoluble organic filter which absorbs UV-B.

The active organic filter content in the UV-A, in particular of the dibenzoylmethane derivative, is advantageously less than 1% by weight, for example between 0.2 and 0.8% by weight, preferably between 0.3. and 0.7% by weight more preferably of the order of 0.5% by weight relative to the weight of the composition.

The composition may contain an active filter in UV-B, preferably liposoluble, which may be chosen from absorbing sunscreens only. wavelengths located in the UV-B, solar filters absorbing both UV-A and UV-B, and mixtures thereof.

The active filter only in the UV-B can be chosen from:

- salicylic derivatives: Homosalate sold especially under the name Neo Heliopan ^® HMS Ethylhexyl salicylate sold in particular under the name NEO

HELIOPAN ^® OS by SYMRISE; Octyl Salicylate sold in particular under the name NEO HELIOPAN ^® type 05;

- cinnamates: EthylhexylMethoxycinnamate sold especially under the trade name Parsol MCX by DSM NutritionalProducts ^®, Inc .; Isopropyl ethoxycinnamate; IsoamylMéthoxycinnamate sold especially under the trade name Neo Heliopan ^® E 1000 by Symrise; DiisopropylMéthylcinnamate; Cinnoxate; GlycérylEthylhexanoate-

dimethoxycinnamate;

- the benzylidenecamphor derivatives: 3-benzylidene camphor manufactured under the name Mexoryl ^® SD by Chimex; Methylbenzylidene camphor sold in particular under the name NEO HELIOPAN ^® MBC;

- triazine derivatives: ethylhexyltriazone sold especially under the trade name Uvinul ^® T150 by BASF, DiethylhexylButamidoTriazone sold under the trade name UVASORB ^® HEB, Bis EthylhexyloxyphenolMethoxyphenyl- triazine;

para-aminobenzoates, such as Ethyl PABA; Ethyl dihydroxypropyl PABA; EthylhexylDiméthyl PABA (ESCALOL ^® 507 from ISP);

imidazoline derivatives: EthylhexylDimethoxybenzylideneDioxoimidazoline-Propionate;

- derivatives Benzalmalonate: polyorganosiloxanes Benzalmalonate function as Polysilicone-15, sold especially under the trade name Parsol ^® SLX by DSM Nutritional Products Inc .; Di-neopentyl-4'-methoxybenzalmalonate;

- and their mixtures.

An active filter in both UV-A and UV-B can be selected from:

- the benzophenone derivatives: Benzophenone-1 sold under the trade name Uvinul ^® 400; Benzophenone-2 sold under the trade name Uvinul D50; Benzophenone-3 or oxybenzone sold under the trade name Uvinul ^® M40; Benzophenone-4 sold under the trade name Uvinul MS40 ^®; Benzophenone-6 sold under the trade name HELISORB 11; Benzophenone-8 sold under the trade name SPECTRASORB ^® UV-24; - derivatives phenylbenzotriazole: DrométrizoleTrisiloxane sold especially under the name Silatrizole ^® by Rhodia Chimie; Methylene bis benzotriazolyltetramethylbutylphenol sold in solid form especially under the trade name MIXXIM ^® BB / 100 by Fairmount Chemical;

bis-resorcinyltriazine derivatives: Bis-

EthylhexyloxyphenolMethoxyphenylTriazine sold in particular under the trade name ΉΝθεθ ^ Β ^® S by CIBA GEIGY;

benzoxazole derivatives: 2,4-bis [5- (1-dimethylpropyl) benzoxazol-2-yl- (4-phenyl) imino] -6- (2-ethylhexyl) imino-1,3,5- triazine sold in particular under the name Uvasorb ^® K2A by Sigma 3V;

- and their mixtures.

According to one embodiment of the invention, the organic solar filter is a mixture of an absorbing solar filter in the UV-A and a filtering solar filter in the UV-B.

For example, a liposoluble UV-B filter selected from cinnamates, especially ethylhexyl methoxycinnamate (INCI name) or Octinoxate (USAN name) sold under the trade name PARSOL, may be added to an organic filter active in the UV-A region. ^® MCX.

The organic sunscreen may be a mixture of butylmethoxydibenzoylmethane (USAN Avobenzone) and ethylhexylmethoxycinnamate (USAN Octinoxate).

The liposoluble organic filter content UV-B, in particular ethylhexyl-methoxycinnamate, in the composition of the invention is advantageously less than 1.2%, for example between 0.5 and 1.2% by weight, preferably between 0 and , 8 and 1.2% by weight, more preferably of the order of 1% by weight relative to the weight of the composition.

According to one mode of implementation, the mass ratio between the dibenzoylmethane derivative and the cinnamate derivative is between 0.3 and 0.7, preferably of the order of 0.5.

The organic sunscreen comprising a derivative of dibenzoylmethane and a cinnamate derivative is advantageously present in an amount of between 0.5 and 2.2% by weight, preferably between 1.2 and 1.8% by weight, more preferably between the order of 1.5% by weight relative to the total weight of the composition.

The compositions of the invention also contain a volatile solvent, which preferably solubilizes the polymer and the plasticizer. This allows Solubilize and homogenize the ingredients and its volatile nature helps to form a solid and continuous film on the skin as a result of the application.

In the context of the present invention, the term "volatile solvent" means a solvent capable of evaporating rapidly on contact with the skin. Water is excluded from this definition. Volatile solvents or volatile solvent mixtures having a boiling point above 50 ° C (at atmospheric pressure) are preferred.

As a usable solvent, mention may be made of:

ketones such as methyl ethyl ketone, methyl isobutyl ketone, diisobutyl ketone, isophorone, cyclohexanone, acetone;

alcohols such as ethanol, isopropanol, n-propanol, n-butanol, diacetone alcohol, 2-butoxyethanol, cyclohexanol;

glycols such as ethylene glycol, propylene glycol, pentylene glycol, glycerol;

propylene glycol ethers such as propylene glycol monomethyl ether, propylene glycol monomethyl ether acetate, dipropylene glycol mono-butyl ether;

esters such as ethyl acetate, methyl acetate, propyl acetate, n-butyl acetate and isopentyl acetate;

methylal;

ethers such as diethyl ether, dimethyl ether or dichlorodiethyl ether;

silicone solvents, in particular hexamethylsiloxane and polydimethylsiloxanes;

- their mixtures.

The volatile solvent will advantageously be chosen from ethanol, ethyl acetate and their mixtures. In particular, one will choose a mixture of ethyl acetate and ethanol in proportions of between 1/1 and 3/1, preferably 2/1. The amount of volatile solvent is preferably 60 to 90% by weight relative to the total weight of the composition, preferably 70 to 90% by weight relative to the total weight of the composition.

The composition is essentially free of water. It preferably contains less than 2% by weight.

The compositions according to the invention may also contain additives normally used in the preparation of dressings, such as perfumes, preservatives, depigmenting agents, antibacterial agents, antifungal agents, healing agents, painkillers, anti-inflammatory agents, anti- inflammatory, moisturizing agents, keratolytic agents, vitamins, glycerin, citric acid.

In general, the assets are chosen from:

anti-bacterials such as polymyxin B, penicillins (amoxycillin), clavulanic acid, tetracyclines, minocycline, chlorotetracycline, aminoglycosides, amikacin, gentamicin, neomycin, silver and its salts (Sulfadiazine argentic), probiotics;

antiseptics such as sodium mercurothiolate, eosin, chlorhexidine, phenylmercury borate, hydrogen peroxide, Dakin liquor, triclosan, biguanide, hexamidine, thymol, Lugol, Povidone iodine, Merbromine, Benzalkonium and Benzethonium Chloride, ethanol, isopropanol;

anti-virals such as Acyclovir, Famciclovir, Ritonavir;

anti fungal agents such as polyenes, Nystatin, Amphotericin B, Natamycin, imidazoles (Miconazole, Ketoconazole, Clotrimazole, Ecconazole,

Bifonazole, Butoconazole, Fenticonazole, Isoconazole, Oxiconazole, Sertaconazole, Sulconazole, Thiabendazole, Tioconazole), triazoles (Fluconazole, Itraconazole, Ravuconazole, Posaconazole, Voriconazole), allylamines, Terbinafine, Amorolfine, Naftifine, Butenafine;

Flucytosine (antimetabolite), Griseofulvin, Caspofungin, Micafungin;

anti-pain agents such as paracetamol, codeine, dextropropoxyphene, tramadol, morphine and its derivatives, corticosteroids and derivatives;

anti-inflammatories such as glucocorticoids, nonsteroidal anti-inflammatory drugs, aspirin, ibuprofen, ketoprofen, flurbiprofen,

Diclofenac, Aceclofenac, Ketorolac, Meloxicam, Piroxicam, Tenoxicam, Naproxen, Indomethacin, Naproxcinod, Nimesulide, Celecoxib, Etoricoxib, Parecoxib, Rofecoxib, Valdecoxib, Phenylbutazone, niflumic acid, mefenamic acid;

the active agents promoting healing such as retinol, vitamin A, vitamin E, N-acetyl-hydroxyproline, extracts of Centella Asiatica, papain, silicones, essential oils of thyme, niaouli, rosemary and of sage, hyaluronic acid, synthetic polysulfated oligosaccharides having 1 to 4 units such as the potassium salt of octasulfated sucrose, the silver salt of octasulfated sucrose or sucralfate, Allantoin; depigmenting agents such as kojic acid (Kojic Acid SL ^® - Quimasso (Sino Lion)), Arbutin (Olevatin ^® - Quimasso (Sino Lion)), the mixture of palmitoylpropyl of sodium and white water lily extract (Sepicalm ^® - Seppic), undecylenoyl phenylalanine (Sepiwhite ^® - Seppic), licorice extract obtained by fermentation with Aspergillus and ethoxydiglycol (Gatuline Whitening ^® - Gattefossé), octadecenedioic acid (ODA White ^® - Sederma) , alpha-arbutin (alpha-arbutin ^®, SACI-CFPA (Pentapharm)), the aqueous extract of leaves Arctophylos Uva Ursi (elfade-J ^® - SACI-CFPA (Pentapharm)), the complex mixture of plant Gigawhite ^® (SACI-CFPA (Alpaflor)), diacetyl boldine (Lumiskin ^® - Sederma), mandarin extract from Japan (Melaslow ^® - Sederma), lemon extract mixture enriched with citric acid and cucumber extract (Uninontan ^® U-34 - Unipex), the mixture of Rumex occidentalis extract and vitamin C (Tyrostat ^® 11 - Unipex), oligopeptides (Melanostatin 5 ^® - Unipex), kojic dipalmitate (KAD-15 ^® - Quimasso (Sino Lion)), LCW Vegewhite ^® natural origin complex, wheat germ extracts (Clariskin ^® II - Silab) ethyldiamine triacetate (EDTA);

keratolytic agents such as salicylic acid, zinc salicylate, ascorbic acid, alpha hydroxylated acids (glycolic acid, lactic acid, malic acid, citric acid, tartaric acid), extracts of silver maple, Griottier, tamarind urea, topical retinoid Keratoline ^® (Sederma), proteases obtained by fermentation of Bacillus Subtilis, the Linked-Papain ^{® product} (SACI-CFPA), papain (proteolytic enzyme derived from papaya fruit);

- Restructuring assets (for example, resuscitators of dander) such as silica derivatives, vitamin E, chamomile, calcium, horsetail extract, Li pester silk;

anesthetics such as benzocaine, lidocaine, dibucaine, pramoxine hydrochloride, bupivacaine, mepivacaine, prilocaine and etidocaine.

As indicated above, the composition according to the present invention is in the form of a fluid liquid intended to be applied using a suitable device. It is advantageously formulated so that it can be used in various possible forms, in particular in the form of a bottle with an appropriate applicator, such as a brush or a palette, a roll-on, or in the form of a spray, of a labial tube. , or mosses.

The subject of the invention is also the composition described above for its use in the protection of scars. According to one embodiment, the compositions according to the present invention are intended to be applied to scars, whether they are related to an accident, a disease or following a surgical procedure.

These compositions can also be used for any skin condition for which UV exposure is undesirable.

Examples include acne, chickenpox, shingles, rosacea, first-degree burns, eczema, hyperpigmentation, lucite, vitiligo, xerosis, prophylaxis, stretch marks, psoriasis, insect bites.

The invention also relates to the use of a composition as defined above for the preparation of a dressing intended to protect risk areas such as scars.

The following examples illustrate the invention without limiting its scope.

Example 1

The following composition was prepared.

Operating mode:

Ingredients 2-6 were mixed with stirring at 700 rpm for 10 minutes with a propeller stirrer. The nitrocellulose was then dispersed in the stirred mixture, and the mixture was stirred successively for 20 minutes at 1100 rpm and for 30 minutes at 2000 rpm.

Measurement of the filtering power:

The composition according to the invention was spread homogeneously and calibrated on an inert support, and then allowed to dry so that the volatile solvent evaporated. A film 10 microns thick was obtained which was separated from the support.

The Sun Protection Factor (SPF) of the composition was measured in vitro on the previously irradiated composition film so as to approach the conditions encountered in vivo. The film was irradiated for 30 minutes with a standard solar light dose of between 2 and 4 DEM. The value of the DEM retained was 25 mJ / cm2 erythemal efficiency, this value corresponding to a 15-minute exposure to the sun at its zenith (standard sun) with an erythemal power of 4 DEM / h, the UVB spectroradiometric flux being 0.365 mW / cm 2 between 290 and 320 nm, the spectroradiometric UVA flux being 6.0 mW / cm 2 between 320 and 400 nm (UVA / UVB ratio: 16.5 / 1).

The method used to measure SPF followed the principles described by B. L. Diffey and J. Robson in J.S.C.C., 40, 127-133, May-June 1989.

The equipment used included:

- A spectrophotometer "KONTRON 930" equipped with a UV source and a doublemonochromateur capable of delivering a flow of energy between 250 and 800 nm;

- A light source for irradiation: CPS + SUNTEST (ATLAS) with standard filter and Schott WG 320 filter. A PMMA plate containing UV filters is used as a reference.

The average value of the SPF obtained from 3 to 5 measurements on the 10 μm film was 243 (± 74).

The film of the invention has protective properties vis-à-vis

UVA and UVB, with a good spectral distribution between UVA and UVB. The critical wavelength is 370 nm.

Example 2

The following composition was prepared following the procedure of Example 1.

The average value of the SPF was calculated according to the method of the example

1. The mean value of SPF obtained after pre-irradiation on 5 measurements was 17.10 (± 0.32). The product therefore had effective sun protection. Comparative Example 3

The following composition was prepared:

Operating mode:

The nitrocellulose content (percent by dry weight) of Example 4 was 20%. The composition according to Example 4 was very viscous and stringy. As a result, it was impossible to spread it with a brush. The film obtained was very irregular and not homogeneous.

Comparative Example 4:

The following composition was prepared:

Operating mode:

Ingredients 2-6 were mixed with stirring at 700 rpm for 10 minutes with a propeller stirrer. The nitrocellulose was then dispersed in the stirred mixture, and the mixture was stirred successively for 20 minutes at 1100 rpm and for 30 minutes at 2000 rpm. The nitrocellulose content (percentage by dry weight) of Example 5 was 4.8%. The composition according to Example 5 was very liquid and did not allow to obtain a thick enough film on the skin to have the required sunscreen. The formed film was extremely thin, which makes it more sensitive to rubbing and washing.

Comparative Example 5:

The following composition was prepared:

Operating mode:

Measurement of the filtering power:

The composition according to Example 6 was spread homogeneously and calibrated on an inert carrier, and then allowed to dry so that the volatile solvent evaporated. A film 10 microns thick was obtained which was separated from the support. The Sun Protection Factor (SPF) of the composition was measured as in Example 1.

The spectrophotometer showed saturation above 1.2% by weight Parsol MCX. Similarly, for Parsol 1789 saturation was shown at 1% by weight.

Claims

A fluid composition for application to the skin containing a polymer, a plasticizer, a solvent of said polymer, excluding volatile water, and at least one organic sunscreen, characterized in that the total solar filter (s) is between 0.5 and 2.2% by weight of the total weight of the composition, the volatile solvent represents from 60 to 90% by weight relative to the total weight of the composition, and the polymer represents from 5 to 20% by dry weight of the total weight of the composition.

2. Composition according to claim 1, characterized in that the total content of solar filter (s) is between 1.2 and 1.8% by weight of the total weight of the composition, preferably of the order 1.5% by weight.

3. Composition according to one of claims 1 to 2, characterized in that the organic sunscreen is a mixture of a dibenzoylmethane derivative and a liposoluble organic absorbent filter in the UV-B.

4. Composition according to claim 3, characterized in that the dibenzoylmethane derivative represents between 0.3 and 0.7% by weight of the total weight of the composition.

5. Composition according to claims 3 or 4, characterized in that the liposoluble organic absorbent filter in the UV-B represents from 0.8 to

1.2% by weight of the total weight of the composition.

6. Composition according to one of claims 3 to 5, characterized in that the organic sunscreen is a mixture of butyl-methoxydibenzoylmethane (USAN Avobenzone) and ethylhexyl-methoxycinnamate (USAN Octinoxate).

7. Composition according to one of the preceding claims, characterized in that it contains less than 0.5%, preferably less than 0.2% by weight of inorganic solar filter (s) by relative to the total weight of the composition.

8. Composition according to one of the preceding claims, characterized in that the polymer is a nitrocellulose.

9. Composition according to one of the preceding claims, characterized in that the plasticizer is selected from castor oil, wheat germ oil, dibutyl phthalate, glycerin, dibutyl sebacate, acetyl tributyl citrate, triacetin, and their mixtures.

10. Composition according to one of the preceding claims, characterized in that the solvent of said polymer is selected from ethanol, ethyl acetate and mixtures thereof.

11. Composition according to one of the preceding claims, characterized in that it further comprises a healing promoting agent, an anti-bacterial agent, an antifungal agent, a depigmenting agent, an anti-pain agent, an anti-inflammatory agent, inflammatory agent, a moisturizing agent, a keratolytic agent, vitamins, or a mixture of these compounds.

12. Composition according to one of the preceding claims for use as a dressing for the protection of scars.