EP2616179A1 - Dispositif de raccordement pour la mise en contact fluidique de puces microfluidiques - Google Patents

Dispositif de raccordement pour la mise en contact fluidique de puces microfluidiques

Info

Publication number
EP2616179A1
EP2616179A1 EP11769806.8A EP11769806A EP2616179A1 EP 2616179 A1 EP2616179 A1 EP 2616179A1 EP 11769806 A EP11769806 A EP 11769806A EP 2616179 A1 EP2616179 A1 EP 2616179A1
Authority
EP
European Patent Office
Prior art keywords
sleeve
flange
connector
connecting device
microfluidic chip
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP11769806.8A
Other languages
German (de)
English (en)
Inventor
Frank K. Gehring
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Andreas Hettich GmbH and Co KG
Original Assignee
Andreas Hettich GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Andreas Hettich GmbH and Co KG filed Critical Andreas Hettich GmbH and Co KG
Publication of EP2616179A1 publication Critical patent/EP2616179A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
    • F16L11/00—Hoses, i.e. flexible pipes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56—Labware specially adapted for transferring fluids
    • B01L3/565—Seals

Definitions

  • the invention comprises a connection device for the fluidic contacting of microfluidic chips, according to the preamble of claim 1.
  • a macrofluidic conduit with an elastic sleeve is lengthened for contacting microfluidic platforms
  • the sleeve is inserted in a contact body which has a recess with the outside diameter of the sleeve, and the elastic sleeve is selected so that it projects beyond the contact body in its axial extent
  • the elastic sleeve is compressed in its receptacle in the contact body and seals the microfluidic chip and contact body against each other
  • the contact body has holes on its side facing away from the microfluidic chip for inserting macrophilic Uidischen lines that correspond to the inner diameter of the sleeve.
  • a macrofluidic line can thus be inserted into the elastic sleeve.
  • the elastic sleeve undergoes a change in cross-section of the inside diameter and thus seals the transition between the macrofluidic line and the sleeve.
  • This embodiment has the disadvantage that the support surface is very small, and the sealing surface is prone to contamination. In addition, inaccuracies in the position of the microfluidic chip can not be compensated.
  • connection device for contacting microfluidic chips, which provides a high degree of tightness available, can be quickly and easily connected to the microfluidic chip and released again.
  • the object is solved by the features of claim 1.
  • the connecting device has at least one connector, wherein a connector comprises a sleeve, at the end of which there is a flange ring.
  • the flange ring lies between the facing surfaces of the carrier plate and the microfluidic chip to be contacted.
  • This flanged ring attached to the sleeve improves the sealing behavior. Contrary to the prior art, in which only a small footprint, the annular surface between the inner and outer diameter is sealed, the sealing surface is significantly increased by the projections of a flange. In addition, the power line changes such that the received in the contact body sleeve structure undergoes no narrowing of the cross section or its inner diameter. This ensures a reproducibility of the flow properties with improved seal.
  • the molding of a flange seal on an elastic sleeve has the advantage that an equivalent seal can be achieved with less contact force.
  • a more or less attenuating layer results between the fluid connection plate and the microfluidic chip. This avoids tension of the fluid chip and guarantees its function.
  • the flange has a compensation function, which makes it possible to compensate for minor bumps or tolerances in the production of the fluid chip.
  • the sleeve and the flange are integrally formed. This has the advantage of an optimal introduction of force. In addition, it avoids a small gap in which dirt particles can penetrate.
  • the handling is significantly improved by one-piece fittings.
  • the flange rings are glued or sprayed directly onto the carrier surface. This improves both the handling when connecting the carrier plate with the microfluidic chip, as well as during cleaning.
  • a microfluidic chip can be contacted very quickly and nevertheless reliably releasably.
  • the centering can preferably be done via the connection plate.
  • this type of connection several connection points of a fluid chip can be contacted simultaneously. This saves a lot of time compared to conventional screwed connections, which all have to be individually screwed into the respective receptacles.
  • the sealing connections are made of PDMS or other resistant and elastic plastic compounds.
  • the recess in the flange has a slightly smaller diameter than the sleeve and a slightly larger diameter than the microfluid connection opening to be contacted.
  • the opening cross section in the flange corresponds to the inner diameter of the hose. This results in an exceptionally small dead volume.
  • the plastic connectors are preferably already integrated into the carrier plate or can be used in an alternative embodiment later in the carrier plate.
  • the cross section of the recess in the carrier plate for receiving the sleeve is chosen to be slightly smaller than the outer diameter of the plastic sleeve. This leads to a compression of the sleeve in the radial direction, which significantly improves the tightness relative to the hose.
  • the flange ring can be designed so that the inner diameter of the flange ring corresponds to that of the line. In particular, then lies the annular surface of the line on the flange.
  • FIG. 1 shows an exploded view of a microfluidic system comprising the connecting device according to the invention
  • Fig. 2 is a sectional view of the composite microfluidic system
  • Fig. 3 is a detail sectional view of the connecting device.
  • FIG. 1 shows an exploded view of a microfluidic system, comprising a base plate, a microfluidic chip, a connection plate with connectors inserted, and a holding device 18 for receiving a quick-release fastener 20.
  • the holder 18 is mounted on the base plate 10. Between the holder 18 of the microfluidic chip 12 is inserted.
  • the support plate 14 has on the microchip zugewanden side recesses into which the connectors 16 are inserted. Recesses are provided on the side remote from the microchip into which a macrofluidic line or a hose can be inserted.
  • the macrofluidic tube is inserted into the sleeve 22 of a connector.
  • centering pins 24 are provided, which extend through the bottom plate, the microfluidic chip and the carrier plate, in order to ensure that the connection openings of the microfluidic chip and that of the connectors 16 are aligned with one another.
  • microfluidic chips can be contacted in a simple manner. This is especially true when all microfluidic chips have the openings for access to the microfluidic system within the chip at the same position. In this way, different chips can be quickly and easily inserted and removed in an appropriate device.
  • the connections have a high flexibility with high seal and low dead volume.
  • Fig. 2 shows a sectional view in which also the tube inserted into a connector is shown.
  • This illustration shows the bottom plate 10, the microfluidic chip 12, the carrier plate 14, an adjusting pin 22 and a connector 16 installed in the carrier unit.
  • the carrier is braced against the bottom plate. This results in a compression of the integrally formed on the sleeve 22 flange 26 in the area in which this is between the support plate 14 and the microfluidic chip 12.
  • In the opening of the microfluidic chip 12 is aligned or coaxially aligned with the associated connector 16.
  • FIG. 3 shows a detailed sectional view of a connector 16 in a carrier plate 14, wherein the connector 16 is placed on a microfluidic chip 12.
  • the connector 16 comprises a sleeve 22 and a flange ring 26 integrally formed on it.
  • the end of a macrofluidic hose 28 is inserted into the sleeve.
  • the inner diameter of the recess in Make the flange so that it corresponds to the inner diameter of the hose. This ensures that no dead volume between tube 30 and sleeve 22 is formed, provided that the tube 30 is pushed up to the flange 26.
  • the inner diameter of the flange ring 26 is dimensioned such that it is slightly larger than the opening of the fluid chip. As a result, tolerances in the connection can be compensated and a contact can be ensured despite inaccuracies.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mechanical Engineering (AREA)
  • Quick-Acting Or Multi-Walled Pipe Joints (AREA)
  • Micromachines (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

L'invention concerne un dispositif de raccordement pour la mise en contact fluidique d'une puce microfluidique (12), des ouvertures étant pratiquées dans la surface de la puce microfluidique (12) et le dispositif de raccordement comportant une plaque de support (14) et au moins un connecteur (16). L'invention est caractérisée en ce que le connecteur (16) présente une douille (22) et une bride (26) disposée coaxialement à la douille (22), le diamètre intérieur de la douille (22) est dimensionné de telle manière qu'il accueille un tuyau macrofluidique (30), et le diamètre extérieur est dimensionné de telle manière que la douille (22) puisse être accueillie dans un évidement pratiqué dans la plaque de support (14).
EP11769806.8A 2010-09-14 2011-09-14 Dispositif de raccordement pour la mise en contact fluidique de puces microfluidiques Withdrawn EP2616179A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010037532A DE102010037532A1 (de) 2010-09-14 2010-09-14 Anschlussvorrichtung zur fluidischen Kontaktierung von Mikrofluidikchips
PCT/EP2011/065946 WO2012041705A1 (fr) 2010-09-14 2011-09-14 Dispositif de raccordement pour la mise en contact fluidique de puces microfluidiques

Publications (1)

Publication Number Publication Date
EP2616179A1 true EP2616179A1 (fr) 2013-07-24

Family

ID=44799996

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11769806.8A Withdrawn EP2616179A1 (fr) 2010-09-14 2011-09-14 Dispositif de raccordement pour la mise en contact fluidique de puces microfluidiques

Country Status (6)

Country Link
US (1) US20130206268A1 (fr)
EP (1) EP2616179A1 (fr)
JP (1) JP2013543427A (fr)
CN (1) CN103260761A (fr)
DE (1) DE102010037532A1 (fr)
WO (1) WO2012041705A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103878038B (zh) * 2012-12-19 2015-09-09 中国科学院大连化学物理研究所 一种通用型微流控芯片夹具
CN103406164B (zh) * 2013-07-15 2015-04-01 广东凯普生物科技股份有限公司 可移动带磁力载膜平台
CN105536904B (zh) * 2015-12-15 2018-04-10 苏州汶颢芯片科技有限公司 可逆微流控芯片夹具
CN105772125B (zh) * 2016-04-23 2018-09-21 北京化工大学 基于3d打印的微流控芯片夹具实验平台

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US2812959A (en) * 1953-08-21 1957-11-12 Westinghouse Air Brake Co Flange union fitting with gland expandible into an opening
US5061635A (en) * 1987-07-13 1991-10-29 City Of Hope Protein or peptide sequencing method
EP0617278A1 (fr) * 1993-03-12 1994-09-28 Orion Research, Incorporated Connexions de tubes capillaires pour la chromatographie et l'électrophorèse
DE9413553U1 (de) * 1994-08-23 1994-10-13 Hewlett-Packard GmbH, 71034 Böblingen Verbindungskapillare
US6319476B1 (en) * 1999-03-02 2001-11-20 Perseptive Biosystems, Inc. Microfluidic connector
DE10213272A1 (de) * 2002-03-25 2003-10-23 Evotec Ag Vorrichtung und Verfahren zur Leitungsankopplung an fluidische Mikrosysteme
US7311882B1 (en) * 2003-01-24 2007-12-25 Sandia National Laboratories Capillary interconnect device
US7553455B1 (en) * 2003-04-02 2009-06-30 Sandia Corporation Micromanifold assembly
DE602006021151D1 (de) * 2006-05-11 2011-05-19 Corning Inc Modulares Halte- und Verbindungssystem für microfluidische Vorrichtungen
WO2009002152A1 (fr) * 2007-06-26 2008-12-31 Micronit Microfluidics B.V. Dispositif et procédé permettant le couplage fluidique de conduits fluidiques à une puce microfluidique et leur découplage
KR101563689B1 (ko) * 2009-03-13 2015-11-09 삼성전자주식회사 튜브 연결용 부속품 및 이를 구비한 미세유동 시스템
US8337783B2 (en) * 2009-06-23 2012-12-25 The United States of America as represented by the Secretary of Commerce, the National Institute of Standards and Technology Magnetic connectors for microfluidic applications
DE102009053285B4 (de) * 2009-11-13 2012-10-04 Karlsruher Institut für Technologie Verfahren zum reversiblen, parallelen Schließen einer Vielzahl von fluidischen Zuleitungen mit einem mikrofluidischen System
US8569070B2 (en) * 2010-07-16 2013-10-29 Idex Health & Science Llc Connection assembly for ultra high pressure liquid chromatography
JP5906935B2 (ja) * 2012-05-15 2016-04-20 株式会社島津製作所 ニードルとニードルポートの接続構造

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Title
See references of WO2012041705A1 *

Also Published As

Publication number Publication date
CN103260761A (zh) 2013-08-21
JP2013543427A (ja) 2013-12-05
DE102010037532A1 (de) 2012-03-15
WO2012041705A1 (fr) 2012-04-05
US20130206268A1 (en) 2013-08-15

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