EP2614849A1 - Unité de dispersion - Google Patents

Unité de dispersion Download PDF

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Publication number
EP2614849A1
EP2614849A1 EP13158374.2A EP13158374A EP2614849A1 EP 2614849 A1 EP2614849 A1 EP 2614849A1 EP 13158374 A EP13158374 A EP 13158374A EP 2614849 A1 EP2614849 A1 EP 2614849A1
Authority
EP
European Patent Office
Prior art keywords
chamber
outlet
axial
dispersion unit
unit according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP13158374.2A
Other languages
German (de)
English (en)
Other versions
EP2614849B1 (fr
Inventor
Jürgen JAUERNIG
Thomas Weuthen
Stefan Mackeben
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of EP2614849A1 publication Critical patent/EP2614849A1/fr
Application granted granted Critical
Publication of EP2614849B1 publication Critical patent/EP2614849B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows

Definitions

  • the present invention relates to a dispersion unit for a powder inhaler.
  • Such dispersing units are basically known and serve to produce a dispersion of an aerosol, the aerosol consisting of a mixture of active ingredient and carrier, e.g. Lactose exists.
  • the carrier serves primarily to enhance the physical properties of the formulation, e.g. to control their flowability.
  • the fine active ingredient mainly adheres to the surface of the coarse carrier substance.
  • the adhesion forces between carrier and active substance particles or between active ingredient particle agglomerates must be overcome during inhalation in order to generate a high proportion of respirable active ingredient particles.
  • the energy required for this purpose can be introduced in a dispersion unit.
  • Impact forces or turbulence or a combination of both are used for dispersion in known dispersing units. It is also known to produce a dispersion with the help of baffles and additional supply air channels.
  • annular channel for supplying a particle flow.
  • the annular channel has an axial inlet and an axial outlet in order to supply the particle stream consisting of a mixture of active substance and carrier substance.
  • annular deflection chamber adjoins the axial outlet of the annular channel, in which the axially entering particle flow is deflected in a predominantly radial flow direction.
  • an acceleration of the particle flow can be achieved in this deflection chamber, so that the particle flow circulates in a circular manner in a direction adjacent to the deflection chamber in the axial direction of the rotary chamber having a circular peripheral wall and an axial outlet.
  • the deflection chamber and the rotation chamber are not used for separating coarse particles, but instead a distribution which differs in the average residence time exploited between coarse and fine particles. Until the end of the inhalation process so coarser particles can leave the rotation chamber, so that no significant powder residues remain, which could worsen the operability of the inhaler or the uniformity of the dose output when applying further doses.
  • the annular channel according to the invention has an axially oriented inlet and outlet.
  • the particle flow introduced into the annular channel can nevertheless also have tangential flow components.
  • guide vanes may be arranged in the deflection chamber, which are oriented obliquely to the axial direction.
  • the particle flow entering axially via an annular space can be deflected in a simple manner into a tangential flow, wherein at the same time an acceleration of the particle flow in the deflection chamber can be effected by the design of the deflection vanes.
  • the guide vanes are curved in order to achieve the desired deflection and acceleration effect. It may be advantageous if the curvature of the guide vanes decreases in the axial direction. In this way, the guide vane can be designed in the manner of a turbine blade in order to achieve the best possible deflection and acceleration. In this context, it may also be advantageous if the vanes have in section the profile of a wing with a curved skeleton line. Also it can be in this Connection be advantageous if the guide vanes in the region of the inlet of the deflection chamber have a rounded front edge and in the region of the outlet of the deflection chamber a less rounded back edge. Test tests have shown that such a profile design can achieve very good results.
  • the axial outlet of the rotary chamber is arranged centrically. As a result, light particles leave the rotation chamber through the outlet early, whereas heavier particles circulate along the peripheral wall of the rotation chamber.
  • a discharge channel adjoins the axial outlet of the rotation chamber, which widens.
  • the extension may be concave, thereby causing the aerosol particles exiting the outlet of the rotary chamber with relatively high velocity components across the inhalation direction to be slowed down in the region of the discharge channel, with the movement of the aerosol in the outlet channel being predominantly oriented longitudinally.
  • the cross-sectional elevation of the discharge channel achieves a slower aerosol exit so that the patient inhales a non-ballistic aerosol.
  • the discharge channel has a circular-cylindrical region in an output-side end section, since this can bring about axial bundling of the discharged particle flow.
  • a concave design of the discharge channel and a convex design is conceivable.
  • the deposition of light particles from the rotation chamber can be additionally improved by the fact that the discharge channel sharp-edged, and in particular connects with an acute-angled cross-section edge to the rotation chamber.
  • no air inlet openings for supplying external air are provided between the axial outlet of the annular channel and the outlet of the rotary chamber. This eliminates the need for applying an additional suction power to maintain the functionality of the dispersion unit, which benefits neither the mobilization of the powder from the dispersing device nor the actual dispersing performance.
  • the deflection of the particle stream and the directed outlet into the pharynx are realized according to the invention solely by geometric shapes.
  • Fig. 1 shows a dispersing unit for a (not shown) powder inhaler with a mouthpiece 10, on the underside of an annular channel 12 is provided for supplying a particle flow.
  • the particle flow is generally generated by suction on the mouthpiece, for example by providing in the inhaler a predetermined dose of active substance and carrier substance, which is then sucked into the annular channel 12 by suction at the mouthpiece.
  • the annular channel 12 is circumferentially formed circumferentially and has an axial inlet 14 and an axial outlet 16, wherein both inlet 14 and outlet 16 extend over the entire circumference of the annular channel 12.
  • a likewise annular deflection chamber 18 is provided, which has approximately the same radial extent as the annular channel 12 and in which the axially entering particle flow is deflected in a predominantly radial flow direction.
  • the essentially radially directed particle flow at the outlet of the deflection chamber 18 is conducted into a rotation chamber 20, which has a circular peripheral wall 22 and an axial outlet 24.
  • the outer diameter of the annular channel 12, the deflection chamber 18 and the rotation chamber 20 are substantially equal. Also, the inner diameter of the annular channel 12 and the inner diameter of the deflection chamber 18 correspond to each other. The inner diameter of the axial outlet 24 of the rotary chamber 20 is less than the inner diameter of the deflection chamber 18.
  • a plurality of guide vanes 26 are provided in the deflection chamber 18 distributed over the circumference, which are oriented obliquely to the axial direction.
  • Each of the vanes 26 extends over the entire cross section of the deflection chamber 18, wherein each vane is curved and the curvature decreases in the axial direction, i. at the inlet of the deflection chamber 18 is stronger than at the outlet.
  • the guide vanes 26 In section (longitudinal section), have the profile of a wing with a curved skeleton line.
  • the guide vanes have a rounded leading edge in the region of the inlet of the deflection chamber 18 and a less rounded trailing edge in the region of the outlet of the deflection chamber 18, so that the profile of the guide vanes 26 resembles an aircraft wing.
  • the peripheral wall 22 of the rotary chamber 20 is circular cylindrical and connects directly to the outlet of the deflection chamber 18, wherein the axial extent of the deflection chamber 18 and the rotation chamber 20 is approximately equal.
  • the rotation chamber 20 has an end wall 28, which forms a transition between the peripheral wall 22 and the centrally arranged axial outlet 24.
  • the transition from the circular peripheral wall 22 is curved to the end wall 28 in the region of the corner.
  • a discharge channel 30 connects, the peripheral wall 32 widens concave.
  • the transition between the end wall 28 of the rotary chamber 20 and the peripheral wall 32 of the discharge channel 30 is sharp-edged and formed at an acute angle in the illustrated embodiment.
  • the discharge channel 30 has in its output end portion a circular cylindrical portion 33 which extends to the end of the discharge channel 30 and causes an axial concentration of the discharged particle flow.
  • the patient sucks on the mouthpiece 10, whereby a stream of particles in the direction of the illustrated arrows (axial direction) is passed through the mouthpiece, which has been previously provided by a non-illustrated powder inhaler in a desired dose.
  • the sucked-in particle stream is first introduced through the inlet 14 into the annular channel 12 and passes through the annular, axial outlet 16 from the annular channel 12 in the annular deflection 18.
  • the rotation chamber 20 rotates the Particle flow, wherein heavy particles in the region of the circular peripheral wall 22 rotate longer and lighter particles follow the air flow and move faster in the direction of discharge channel 30.
  • the heavier particles circulating in the rotation chamber 20 initially release progressively smaller (active) particles during their circulation by contact with the peripheral wall 22 until these particles circulating in the rotation chamber 20 likewise follow the air flow and are then discharged.
  • the dispersing unit described is made according to an advantageous embodiment of plastic.
  • mouthpiece 12 annular channel 14 Inlet of the annular channel 16 Outlet of the ring channel 18 deflection 20 rotation chamber 22 circular peripheral wall 24 Outlet of the rotation chamber 26 vanes 27 commitment 28 bulkhead 30 discharge channel 32 peripheral wall 33 circular cylindrical area

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nozzles (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Structures Of Non-Positive Displacement Pumps (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Colloid Chemistry (AREA)
EP13158374.2A 2006-02-17 2007-01-09 Unité de dispersion Not-in-force EP2614849B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006007495A DE102006007495A1 (de) 2006-02-17 2006-02-17 Dispergiereinheit
EP07702637.5A EP1962934B1 (fr) 2006-02-17 2007-01-09 Unite de dispersion

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
EP07702637.5 Division 2007-01-09
EP07702637.5A Division-Into EP1962934B1 (fr) 2006-02-17 2007-01-09 Unite de dispersion
EP07702637.5A Division EP1962934B1 (fr) 2006-02-17 2007-01-09 Unite de dispersion

Publications (2)

Publication Number Publication Date
EP2614849A1 true EP2614849A1 (fr) 2013-07-17
EP2614849B1 EP2614849B1 (fr) 2017-06-21

Family

ID=38255391

Family Applications (2)

Application Number Title Priority Date Filing Date
EP13158374.2A Not-in-force EP2614849B1 (fr) 2006-02-17 2007-01-09 Unité de dispersion
EP07702637.5A Active EP1962934B1 (fr) 2006-02-17 2007-01-09 Unite de dispersion

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP07702637.5A Active EP1962934B1 (fr) 2006-02-17 2007-01-09 Unite de dispersion

Country Status (21)

Country Link
US (1) US8807132B2 (fr)
EP (2) EP2614849B1 (fr)
JP (2) JP5360471B2 (fr)
KR (1) KR101359573B1 (fr)
CN (2) CN103157162B (fr)
AR (1) AR059332A1 (fr)
AU (1) AU2007218385B2 (fr)
BR (1) BRPI0708072A2 (fr)
CA (2) CA2872281C (fr)
CL (1) CL2007000429A1 (fr)
DE (1) DE102006007495A1 (fr)
DK (1) DK1962934T3 (fr)
EA (1) EA014837B1 (fr)
HK (2) HK1097999A2 (fr)
MX (2) MX341005B (fr)
MY (1) MY148154A (fr)
NO (1) NO337268B1 (fr)
NZ (1) NZ570204A (fr)
UA (1) UA95279C2 (fr)
WO (1) WO2007096023A1 (fr)
ZA (1) ZA200806544B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11446451B2 (en) 2017-07-03 2022-09-20 Inhaler Limited Inhaler

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2534958A1 (fr) 2007-12-14 2012-12-19 AeroDesigns, Inc Administration de produits alimentaires sous forme d'aérosols
GR1009186B (el) 2016-09-28 2018-01-09 Κωνσταντινος Παυλου Ζαρογουλιδης Συσκευη χορηγησης εισπνεομενων φαρμακων σε μορφη ξηρας σκονης με αποσπωμενες κεφαλες για τη ρυθμιση της αντιστασης
CN107715264B (zh) * 2017-10-12 2021-01-29 上海新黄河制药有限公司 一种粉雾剂装置制剂粉末团聚物的分散/解聚装置
CN107737393B (zh) * 2017-10-12 2020-08-28 上海新黄河制药有限公司 一种用于粉雾剂吸入装置的制剂雾化流道
WO2020209798A1 (fr) * 2019-04-12 2020-10-15 National University Of Singapore Système de distribution d'aérosol médical inhalable

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999039761A1 (fr) * 1998-02-06 1999-08-12 Unisia Jecs Corporation Dispositif d'inhalation de medicaments
US5954047A (en) * 1997-10-17 1999-09-21 Systemic Pulmonary Development, Ltd. Methods and apparatus for delivering aerosolized medication
EP1068874A1 (fr) * 1999-01-27 2001-01-17 Unisia Jecs Corporation Distributeur de medicament du type inhalateur
US20040107963A1 (en) * 2002-12-02 2004-06-10 The Governors Of The University Of Alberta Device and method for deagglomeration of powder for inhalation

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1295081A (en) 1969-01-08 1972-11-01 Fisons Pharmaceuticals Ltd A method and device for dispensing particulate medicament material from a container
US3838686A (en) * 1971-10-14 1974-10-01 G Szekely Aerosol apparatus for inhalation therapy
US3795244A (en) * 1973-02-02 1974-03-05 Syntex Corp Inhalation device
US3938686A (en) * 1974-11-18 1976-02-17 Milligan Robert T Paint container
SE453566B (sv) 1986-03-07 1988-02-15 Draco Ab Anordning vid pulverinhalatorer
DE407028T1 (de) * 1989-05-31 1994-03-17 Fisons Plc Medikament und Inhalationsvorrichtung dafür.
JP3230056B2 (ja) * 1991-07-02 2001-11-19 インヘイル・インコーポレーテッド 薬剤のエーロゾル化服用量を形成する装置
DE4208880A1 (de) * 1992-03-19 1993-09-23 Boehringer Ingelheim Kg Separator fuer pulverinhalatoren
JPH08103499A (ja) 1994-10-04 1996-04-23 Unisia Jecs Corp 吸入式投薬器
SE9404439D0 (sv) * 1994-12-21 1994-12-21 Astra Ab Inhalation device
US5474059A (en) * 1995-04-08 1995-12-12 Cooper; Guy F. Aerosol dispensing apparatus for dispensing a medicated vapor into the lungs of a patient
DE19522415C2 (de) 1995-06-21 2003-12-04 Sofotec Gmbh & Co Kg Arzneimittelpulverpatrone mit integrierter Dosiereinrichtung und Pulverinhalator mit Mitteln zum Betätigen der Dosiereinrichtung der Arzneimittelpulverpatrone
DE19522416C2 (de) * 1995-06-21 2003-11-20 Sofotec Gmbh & Co Kg Vorrichtung zum Dispergieren von Pulver in einem Luftstrom zur Verwendung mit Pulver-Inhalatoren
GB9513218D0 (en) * 1995-06-29 1995-09-06 Fisons Plc Inhalation device and method
JP3317823B2 (ja) * 1995-08-11 2002-08-26 株式会社ユニシアジェックス 投薬器
SE9503344D0 (sv) * 1995-09-27 1995-09-27 Astra Ab Inhalation device
US5875774A (en) * 1996-01-05 1999-03-02 Sunrise Medical Hhg Inc. Nebulizer
GB9626263D0 (en) * 1996-12-18 1997-02-05 Innovata Biomed Ltd Powder inhaler
SE9700937D0 (sv) * 1997-03-14 1997-03-14 Astra Ab Powder inhaler I
GB9720283D0 (en) 1997-09-25 1997-11-26 Norton Healthcare Ltd Inhaler spacer
WO1999037461A1 (fr) 1998-01-21 1999-07-29 Protool Ag Manchon mobile distributeur de la matiere plastique fondue permettant de compenser la dilatation thermique entre le canal de carotte chauffe et l'entree du moule
DE19825434C2 (de) * 1998-01-30 2002-03-28 Ig Spruehtechnik Gmbh Inhalationsgerät für pulverförmige Medikamente
JP3739955B2 (ja) * 1999-01-11 2006-01-25 株式会社日立製作所 吸入式投薬器
US6363932B1 (en) 2000-07-06 2002-04-02 Clinical Technologies, Inc. Aerosol enhancement device
FI20002363A0 (fi) 2000-10-27 2000-10-27 Orion Yhtymae Oyj Jauheinhalaattori
US6482245B2 (en) * 2001-03-30 2002-11-19 Armstrong International Centrifugal particulate matter gas separator
US6681768B2 (en) * 2001-06-22 2004-01-27 Sofotec Gmbh & Co. Kg Powder formulation disintegrating system and method for dry powder inhalers
DE10129703A1 (de) * 2001-06-22 2003-01-02 Sofotec Gmbh & Co Kg Zerstäubungssystem für eine Pulvermischung und Verfahren für Trockenpulverinhalatoren
GB0209494D0 (en) * 2002-04-25 2002-06-05 Optinose As Nasal devices
AU2003276447A1 (en) 2002-11-04 2004-06-07 Cambridge Consultants Limited Inhalers
US7107987B2 (en) * 2004-02-10 2006-09-19 Cfd Research Corporation Spacer for delivery of medications from an inhaler to children and breathing impaired patients
WO2006031775A2 (fr) * 2004-09-13 2006-03-23 Oriel Therapeutics, Inc. Inhalateurs a poudre seche d'inhibition d'agregat, dispositifs et procedes associes
CN101252964A (zh) * 2005-05-12 2008-08-27 科斯生命科学公司 用于定剂量的吸入器的剂量计数器
DE102009030185A1 (de) * 2009-06-24 2010-12-30 Joachim Kern Turboinhalator

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5954047A (en) * 1997-10-17 1999-09-21 Systemic Pulmonary Development, Ltd. Methods and apparatus for delivering aerosolized medication
WO1999039761A1 (fr) * 1998-02-06 1999-08-12 Unisia Jecs Corporation Dispositif d'inhalation de medicaments
EP1068874A1 (fr) * 1999-01-27 2001-01-17 Unisia Jecs Corporation Distributeur de medicament du type inhalateur
US20040107963A1 (en) * 2002-12-02 2004-06-10 The Governors Of The University Of Alberta Device and method for deagglomeration of powder for inhalation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11446451B2 (en) 2017-07-03 2022-09-20 Inhaler Limited Inhaler
US11980711B2 (en) 2017-07-03 2024-05-14 Inhaler Limited Inhaler

Also Published As

Publication number Publication date
KR101359573B1 (ko) 2014-02-11
CN103157162A (zh) 2013-06-19
WO2007096023A1 (fr) 2007-08-30
EA014837B1 (ru) 2011-02-28
MX341005B (es) 2016-08-03
NO337268B1 (no) 2016-02-29
AU2007218385B2 (en) 2013-02-07
CA2641557A1 (fr) 2007-08-30
EP1962934B1 (fr) 2016-01-06
AR059332A1 (es) 2008-03-26
NO20083381L (no) 2008-08-04
CA2872281C (fr) 2017-01-24
US20100000530A1 (en) 2010-01-07
HK1097999A2 (en) 2007-07-06
UA95279C2 (en) 2011-07-25
DE102006007495A1 (de) 2007-08-23
BRPI0708072A2 (pt) 2011-05-17
NZ570204A (en) 2011-03-31
CL2007000429A1 (es) 2008-01-18
CN101384290B (zh) 2013-03-27
AU2007218385A1 (en) 2007-08-30
JP5360471B2 (ja) 2013-12-04
JP2012232183A (ja) 2012-11-29
US8807132B2 (en) 2014-08-19
CA2872281A1 (fr) 2007-08-30
JP2009526580A (ja) 2009-07-23
CN101384290A (zh) 2009-03-11
EP1962934A1 (fr) 2008-09-03
MY148154A (en) 2013-03-15
CA2641557C (fr) 2015-06-30
HK1121417A1 (en) 2009-04-24
DK1962934T3 (en) 2016-04-11
EP2614849B1 (fr) 2017-06-21
MX2008010443A (es) 2009-01-07
CN103157162B (zh) 2015-06-10
EA200870271A1 (ru) 2009-02-27
ZA200806544B (en) 2009-07-29
KR20080103995A (ko) 2008-11-28

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