EP2586430A4 - Pharmazeutische zusammensetzung mit verbesserter löslichkeit eines teilweise löslichen trizyklischen derivats - Google Patents

Pharmazeutische zusammensetzung mit verbesserter löslichkeit eines teilweise löslichen trizyklischen derivats

Info

Publication number
EP2586430A4
EP2586430A4 EP11798395.7A EP11798395A EP2586430A4 EP 2586430 A4 EP2586430 A4 EP 2586430A4 EP 11798395 A EP11798395 A EP 11798395A EP 2586430 A4 EP2586430 A4 EP 2586430A4
Authority
EP
European Patent Office
Prior art keywords
solubility
improved
pharmaceutical composition
partially soluble
tricyclic derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP11798395.7A
Other languages
English (en)
French (fr)
Other versions
EP2586430A2 (de
EP2586430B1 (de
Inventor
Myung-Hwa Kim
Kwang-Woo Chun
In-Hae Ye
Jong-Hee Choi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jeil Pharmaceutical Co Ltd
Original Assignee
Jeil Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jeil Pharmaceutical Co Ltd filed Critical Jeil Pharmaceutical Co Ltd
Publication of EP2586430A2 publication Critical patent/EP2586430A2/de
Publication of EP2586430A4 publication Critical patent/EP2586430A4/de
Application granted granted Critical
Publication of EP2586430B1 publication Critical patent/EP2586430B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/606—Salicylic acid; Derivatives thereof having amino groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP11798395.7A 2010-06-25 2011-06-23 Pharmazeutische zusammensetzung mit verbesserter löslichkeit eines teilweise löslichen trizyklischen derivats Active EP2586430B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20100060720 2010-06-25
KR1020110060003A KR101130754B1 (ko) 2010-06-25 2011-06-21 난용성 트리사이클릭 유도체 화합물의 용해도가 향상된 약학적 조성물
PCT/KR2011/004600 WO2011162560A2 (ko) 2010-06-25 2011-06-23 난용성 트리사이클릭 유도체 화합물의 용해도가 향상된 약학적 조성물

Publications (3)

Publication Number Publication Date
EP2586430A2 EP2586430A2 (de) 2013-05-01
EP2586430A4 true EP2586430A4 (de) 2014-01-15
EP2586430B1 EP2586430B1 (de) 2016-11-02

Family

ID=45608364

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11798395.7A Active EP2586430B1 (de) 2010-06-25 2011-06-23 Pharmazeutische zusammensetzung mit verbesserter löslichkeit eines teilweise löslichen trizyklischen derivats

Country Status (7)

Country Link
US (1) US8906395B2 (de)
EP (1) EP2586430B1 (de)
JP (1) JP5705978B2 (de)
KR (1) KR101130754B1 (de)
CN (1) CN103025323B (de)
ES (1) ES2623758T3 (de)
WO (1) WO2011162560A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108289846B (zh) * 2015-12-08 2020-12-04 正大天晴药业集团股份有限公司 脂质体的制备方法
KR102169710B1 (ko) * 2020-01-08 2020-10-26 제주대학교 산학협력단 커큐민 나노스피어, 그 제조방법 및 이의 용도

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004043363A2 (en) * 2002-11-06 2004-05-27 Azaya Therapeutics, Inc. Protein-stabilized liposomal formulations of pharmaceutical agents
WO2004113281A1 (en) * 2003-06-25 2004-12-29 Je Il Pharmaceutical Co., Ltd. Tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO178843C (no) 1988-07-11 1996-06-19 Sspl Sa Safe Sex Prod Licens Fremgangsmåte for fremstilling av et farmasöytisk preparat for å forhindre seksuelt overförbare sykdommer
US5439686A (en) 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
IT1276996B1 (it) * 1995-06-27 1997-11-04 Indena Spa Derivati della colchicina, loro uso e formulazioni che li contengono
IT1283110B1 (it) * 1996-06-07 1998-04-07 Indena Spa Composti a scheletro colchicinico,loro uso come farmaci e composizioni che li contengono
BR9812316A (pt) 1997-09-16 2001-03-20 Nexstar Pharmaceuticals Inc Formulações de camptotecina lipossÈmica
KR20010101837A (ko) * 1999-02-08 2001-11-14 스톤 스티븐 에프. 리포좀 크기 조절 방법
IT1309184B1 (it) * 1999-02-23 2002-01-16 Vignoni Srl Procedimento ed apparecchiatura per distendere e raccogliere untessuto a maglia prodotto da macchine tessili circolari.
KR100489701B1 (ko) * 2002-10-09 2005-05-16 주식회사 태평양 고농도의 트리터페노이드를 함유하는 미소화 리포좀 및 그제조방법
FR2857875A1 (fr) * 2003-07-25 2005-01-28 Univ Reims Champagne Ardenne Vaccin therapeutique cible contre la p-glycoproteine 170 pour inhiber la resistance multidrogues dans le traitement des cancers
WO2005084710A2 (en) * 2004-03-02 2005-09-15 Massachusetts Institute Of Technology Nanocell drug delivery system
CN101485629B (zh) * 2008-01-16 2013-01-23 沈阳药科大学 一种给药系统及其制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004043363A2 (en) * 2002-11-06 2004-05-27 Azaya Therapeutics, Inc. Protein-stabilized liposomal formulations of pharmaceutical agents
WO2004113281A1 (en) * 2003-06-25 2004-12-29 Je Il Pharmaceutical Co., Ltd. Tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
KR20120000510A (ko) 2012-01-02
CN103025323B (zh) 2014-10-15
EP2586430A2 (de) 2013-05-01
EP2586430B1 (de) 2016-11-02
WO2011162560A3 (ko) 2012-05-03
CN103025323A (zh) 2013-04-03
ES2623758T3 (es) 2017-07-12
JP5705978B2 (ja) 2015-04-22
KR101130754B1 (ko) 2012-03-28
WO2011162560A2 (ko) 2011-12-29
JP2013534523A (ja) 2013-09-05
US20130101647A1 (en) 2013-04-25
US8906395B2 (en) 2014-12-09

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