EP2563481A2 - Préparations eau/huile microbiologiquement stables - Google Patents

Préparations eau/huile microbiologiquement stables

Info

Publication number
EP2563481A2
EP2563481A2 EP10759574A EP10759574A EP2563481A2 EP 2563481 A2 EP2563481 A2 EP 2563481A2 EP 10759574 A EP10759574 A EP 10759574A EP 10759574 A EP10759574 A EP 10759574A EP 2563481 A2 EP2563481 A2 EP 2563481A2
Authority
EP
European Patent Office
Prior art keywords
preparations
methylisothiazolinone
benzethonium chloride
cosmetic
viscosity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP10759574A
Other languages
German (de)
English (en)
Inventor
Manuela Köhler
Jens Schulz
Alexander Filbry
Rainer Kröpke
Jens Nielsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Publication of EP2563481A2 publication Critical patent/EP2563481A2/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/064—Water-in-oil emulsions, e.g. Water-in-silicone emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A61K8/416—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients

Definitions

  • the invention includes cosmetic or dermatological preparations in the form of water in oil emulsions with benzethonium chloride, ethylisothiazolinone, Piroctone
  • Water in oil Emulsions have various advantages for cosmetics: For example, the water resistance of sunscreen formulation is much better than that of oil in water emulsions. Another advantage is that with water in oil it is possible to delay the release of a dissolved in the inner phase of the two-phase system hydrophilic drug, which may be galenic and in the mechanism of action of an active ingredient of advantage.
  • water-in-oil emulsions are very susceptible to various raw materials customary in cosmetics. These include, in particular, salts, alcohols, perfume oils, active ingredients and preservatives.
  • salts include, in particular, salts, alcohols, perfume oils, active ingredients and preservatives.
  • the addition of these substances often leads to an undesirable change in the theological profile.
  • the viscosity can rise, fall or remain the same when the yield point is shifted. This change can happen immediately after intake of these substances or over time, up to several weeks later.
  • a possible change in the theological profile is that the viscosity decreases and thereby falls within a range that no longer allows a user-friendly application. That The product literally runs through your fingers. Such a low viscosity can then no longer be easily corrected by other additives.
  • parabens especially 4-hydroxybenzoic acid and its esters, methylparaben, ethylparaben,, propylparaben, isopropylparaben, butylparaben, isobutylparaben, phenylparaben.
  • Phenoxetol ® known for the preservation of cosmetic products.
  • auxiliaries for microbial stabilization are benzethonium chloride, lauroylethylarginate, octopirox and methylisothiazolinone.
  • Grapefruit seed extracts can be used in cleaning agents but also in medicines (spermicides, lozenges against angina). Grapefruit seed extracts can be used in cleaning agents but also in medicines (spermicides, lozenges against angina). Grapefruit seed extracts can be used in cleaning agents but also in medicines (spermicides, lozenges against angina). Grapefruit seed extracts can be used in cleaning agents but also in medicines (spermicides, lozenges against angina). Grapefruit seed extracts can
  • benzethonium chloride is known, as described, for example, in WO 2007015243 A1, WO 2004034964 A1, EP 1310234 A1, WO 2002008377 A1.
  • Aminate-G (INCI: Glycerol and ethyl lauroyl arginate HCl) shows a large antimicrobial spectrum and is tested as an additive in foods FDA (see eg WO
  • Piroctone Olamine 1-hydroxy-4-methyl-6- (2,4,4-trimethylpentyl) -2 (1H) -pyridone, also referred to as octopirox, is an antimicrobial used as a preservative and has e.g. B. is used in shampoos as anti-dandruff. Octopirox is good
  • Methylisothiazolinone (2-methyl-2 / - / - isothiazol-3-one (MIT)) is a class of compounds with high microbicidal activity, which is mainly used for the preservation of technical products and only a few cosmetic products.
  • methylisothiazolinone is described, for example, in US Pat. No. 6,511,673 or EP 1,488,699 A1 in combination with parabens or phenoxyethanol.
  • the invention includes benzethonium chloride, methylisothiazolinone, piroctone olamine and / or lauroylethylarginate in cosmetic or dermatological W / O preparations.
  • the preparations do not comprise any further preservatives,
  • the proportion of benzethonium chloride, methylisothiazolinone, piroctone olamine and / or lauroylethylarginate is preferably in the range of 0.01 to 5 wt.%, In particular in the range of 0.1 to 2 wt.%, Based on the total mass of the preparation to choose.
  • Benzethonium chloride, methylisothiazolinone, Piroctone olamine and / or Lauroylethylarginat be included.
  • An emulsion is a system of two immiscible ones
  • Liquids wherein one liquid is finely dispersed in the other.
  • the system must be stirred or shaken.
  • An emulsifier prevents the
  • the oil phase is continuous, the water phase is distributed in small droplets therein (example: butter). If the oil phase consists essentially of silicone oil, it is called a water in silicone emulsion (W / Si).
  • the W / O preparations according to the invention also comprise water in silicone emulsions.
  • the consistency of the cream preparations comprising variants A and B was measured at different time intervals using a consistency determination device according to Fligge (according to DE 29 09 087).
  • Preparation B according to the invention leads to viscosity-stable preparations with a constant course of viscosity, which deviates at most by 18% from the initial value at 25 ° C.
  • benzethonium chloride, methylisothiazolinone, piroctone olamine and / or lauroylethylarginate in paraben- and / or phenoxyethanol-free cosmetic or dermatological W / O preparations used to improve the stability of the viscosity of the preparation.
  • viscosity-stabilizing means that the viscosity of the preparations changes by a maximum of 18% at 25 ° C. within 4 weeks.
  • the viscosity of the invention is determined using a Viscotester VT-02, the company Haake at 25 ° C with the aid of the rotating body 1 or 2 and reading the scale 1 and 2 respectively
  • the improved stability is accompanied by an improved shelf life of the preparations.
  • the preparations according to the invention are preferably paraben and / or
  • Phenoxyethanolza still have sufficient microbial stability.
  • Microplate scale examined. The measurement results of the active substances investigated are related to the positive control (PK1). Neither Ethylparaben nor Methylparaben showed efficacy. In comparison, benzethonium chloride,
  • Methylisothiazolinone Piroctone Olamine and Lauroylethylarginat a very good biofilm-inhibiting activity.
  • benzethonium chloride for benzethonium chloride
  • Preservatives are usually among the bactericidal agents.
  • the anti-biofilm agents do not directly interfere with the bacterial metabolism, but merely prevent or dissolve the formation of the bacteria-protecting biofilm.
  • Staphylococcus epidermidis (syn., Staphylococcus albus, Micrococcus epidermidis, Staphylococcus saprophyticus) is a gram-positive, plasma-coagulase-negative, saprophagic bacterium that colonizes human skin and mucous membranes. Furthermore, it is found on food and also settles on polymeric surfaces (e.g., packaging)
  • S. epidermidis has a wide spectrum of antibiotic resistance. This is especially true against penicillin and methicillin. The proportion of resistant strains is now 70%.
  • preparations according to the invention are preferably paraben and / or
  • Phenoxyethanolza still have sufficient microbial stability.
  • Paraben-free or phenoxyethanol-free means that the proportion of parabens and / or phenoxyethanol is less than 1% by weight, based on the total mass of the preparation.
  • the proportion of parabens and phenoxyethanol is 0% by weight.
  • the cosmetic preparations according to the invention may further cosmetic
  • Excipients and other active ingredients such as are commonly used in such preparations, for.
  • substances for preventing the foaming, dyes and color pigments, thickeners, moisturizing and / or moisturizing substances fats, oils, waxes or other conventional constituents of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic solvents or silicone derivatives if the additive does not impair the required properties with regard to the type of emulsion as well as microbiological stability and skin tolerance.
  • the numbers are parts by weight based on the total mass of the preparation.
  • PEG-30 dipolyhydroxystearate - 0.5 0.25 - 3.0
  • cyclic silicone oil 12.5 15 22.0 20.0 15.5 linear silicone oil (dimethicone) 5.0 13.0 5.0 12.0 15.0 hydrogenated polyisobutene 0.5 0.75 1.0 2 , 0 0.25

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Pest Control & Pesticides (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne des préparations cosmétiques ou dermatologiques se présentant sous la forme d'émulsions eau-dans-huile contenant du chlorure de benzéthonium, de la méthylisothiazolinone, de la piroctone olamine et/ou de l'éthyl lauroyl arginate.
EP10759574A 2010-03-29 2010-09-02 Préparations eau/huile microbiologiquement stables Ceased EP2563481A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010013275A DE102010013275A1 (de) 2010-03-29 2010-03-29 Mikrobiologisch stabile anwendungsfreundliche W/O-Zubereitungen
PCT/EP2010/005376 WO2011124242A2 (fr) 2010-03-29 2010-09-02 Préparations eau/huile microbiologiquement stables

Publications (1)

Publication Number Publication Date
EP2563481A2 true EP2563481A2 (fr) 2013-03-06

Family

ID=44586109

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10759574A Ceased EP2563481A2 (fr) 2010-03-29 2010-09-02 Préparations eau/huile microbiologiquement stables

Country Status (3)

Country Link
EP (1) EP2563481A2 (fr)
DE (1) DE102010013275A1 (fr)
WO (1) WO2011124242A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010055768A1 (de) * 2010-12-23 2012-06-28 Beiersdorf Ag Wirkstoffkombinationen aus Glucosylglyceriden und einem oder mehreren Konservierungsmitteln
DE102012219641A1 (de) * 2012-10-26 2014-04-30 Beiersdorf Ag Zweiphasen Produkt
FR3032615B1 (fr) * 2015-02-12 2018-05-25 Laboratoire De Dermo-Cosmetique Animale Composition antimicrobienne pour animaux
DE102015223829A1 (de) * 2015-12-01 2017-06-01 Henkel Ag & Co. Kgaa Leistungsstarke Haarbehandlungsmittel mit Anti-Auswasch-Effekt

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DE2909087C2 (de) 1979-03-08 1982-04-29 Beiersdorf Ag, 2000 Hamburg Vorrichtung zum Ermitteln der Fließeigenschaften zähfließender oder pastöser Stoffe und Anwendung der Vorrichtung zum Ermitteln der Zügigkeit
IE60024B1 (en) * 1987-02-03 1994-05-18 Stiefel Laboratories Ltd Microemulsions
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FR2685638A1 (fr) * 1991-12-31 1993-07-02 Biorga Sa Laboratoires Compositions pour l'usage cosmetique et/ou dermatologique, comprenant une association de pyrithione zinc, de piroctone olamine, et d'un derive de collagene et d'acide gras.
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Also Published As

Publication number Publication date
WO2011124242A3 (fr) 2013-01-31
WO2011124242A2 (fr) 2011-10-13
DE102010013275A1 (de) 2011-09-29

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