Classifications

• • G—PHYSICS
  • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
  • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
  • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
  • G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
  • G21G1/10—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by bombardment with electrically charged particles
• • H—ELECTRICITY
  • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
  • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
  • H05H6/00—Targets for producing nuclear reactions
• • G—PHYSICS
  • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
  • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
  • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
  • G21G1/001—Recovery of specific isotopes from irradiated targets
  • G21G2001/0015—Fluorine
• • G—PHYSICS
  • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
  • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
  • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
  • G21G1/001—Recovery of specific isotopes from irradiated targets
  • G21G2001/0036—Molybdenum
• • G—PHYSICS
  • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
  • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
  • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
  • G21G1/001—Recovery of specific isotopes from irradiated targets
  • G21G2001/0042—Technetium

Definitions

• the invention relates to a method and a device for generating two different radioactive isotopes.
• Such radioactive isotopes are often used in the field of imaging Medizi ⁇ African imaging, for example, when PET imaging and SPECT.
• Radionuclides for PET imaging are often produced near hospitals, for example using cyclotron production devices.
• No. 6,433,495 describes the structure of a target to be irradiated, which is used in a cyclotron for the production of radionuclides for PET imaging.
• WO 2006/074960 describes a process for the production of radioactive isotopes, which are produced by irradiation with a particle beam.
• US 6,130,926 discloses a process for the production of radionuclides using a cyclotron and a target assembly with rotating films.
• JP 1254900 (A) describes a method in which a charged particle beam irradiates a target chamber with a gas contained therein to radioactive isotopes to produzie ⁇ ren.
• the radionuclides to be used are usually obtained in nuclear reactors, often using highly enriched uranium, for example to obtain 99 Mo / 99m Tc.
• highly enriched uranium for example to obtain 99 Mo / 99m Tc.
• international agreements will make it increasingly difficult to operate reactors with highly enriched uranium in the future Bottleneck in delivering radionuclides for SPECT imaging.
• the cross section for the induction of the first nuclear reaction by the interaction of the particle beam with the first starting material having a first peak at a first particle energy
• the cross section for the induction of the second nuclear reaction by the interaction of the particle beam with the second output ⁇ material has a second peak at a second particle energy, which is lower than the first Parti ⁇ kel energy
• the first starting material and the second starting ⁇ material are arranged one behind the other in the beam path of the particle beam, such that the accelerated particle steel initially irradiates the first starting material, whereby the first nuclear reaction is induced, the particle beam thereby loses energy and then the second Trustmate ⁇ rial irradiated, whereby the second nuclear reaction is induced.
• the particles, for example protons are accelerated by using an accelerator unit and ge to a beam formed ⁇ .
• the interaction of the accelerated particle beam with the first starting material produces the first radioactive isotopic ⁇ pe, which can be obtained from the first starting material with different ⁇ be known methods.
• the decelerated particle beam which interacts with the second starting material, generates the second radioactive isotope, which in turn can be obtained from the second starting material.
• the first starting material and the second starting material are arranged separately from one another in the beam path.
• the energy required for irradiation of the second starting material is at least partially achieved by slowing down the particle beam when irradiating the first material.
• the thickness of the first starting material can be constituted of the ⁇ art and be adapted to the following nuclear reaction of the particle beam with the second starting material that is at penetration decelerated by the particle beam, the particle beam to a particle energy, which is in a range in which a nuclear reaction is induced by interaction of the particle beam braked with the second Trustma ⁇ TERIAL which is suitable for the generation ⁇ supply and recovery of the second radioactive isotope.
• it is ensured that the thickness of the first raw material is low enough so that the particles emerging beam has a sufficiently high energy, after emerging from the first raw material to redesignzu- call the desired interaction in two ⁇ th starting material.
• the thickness can be large enough to decelerate the particle beam into the required interaction region, so that additional energy modulators are no longer necessary before the second source material.
• the particle beam can be accelerated to an energy of at least 15 MeV, in particular at least 25 MeV, and up to an energy of more than 50 MeV before irradiating the first starting material.
• the first nuclear reaction takes place in an energy range, which is for generating a usable for the SPECT imaging isotope, such as for the production of 99m Tc from a suitable starting material.
• the first starting material or the second starting material may be in the form of metal, be a chemical compound, be in solid form or be in liquid form.
• Examples game as a liquid solution can be used in which naturally occurring or-enriched isotopes ⁇ find be, which then generate by irradiating the desired radioactive isotope.
• the device according to the invention for producing a first radioactive isotope and a second radioactive isotope with the aid of an accelerated particle beam comprises:
• a first irradiation target comprising a first output ⁇ material and can be directed to which the accelerated particles ⁇ beam, from the first material through a first nuclear reaction obtained by an alternating The effect of the accelerated particle beam with the first starting material is inducible, the first radioactive isotope is generated, and wherein the particle beam is decelerated when irradiated by the first starting material,
• the second radioactive isotope produced is, wherein the cross section for the first nuclear reaction is at a higher particle energy than the cross section for the second nuclear reaction.
• the first radioactive isotope can be used for the SPECT
• Imaging be suitable radionuclide, in particular 99m Tc
• the second radioactive isotope can be used for the PET
• Imaging be suitable radionuclide, in particular X1 C,
• the accelerator unit can for accelerating the Par tikelstrahls before irradiation of the first raw material to an energy of at least 15 MeV, in particular Minim ⁇ least 25 MeV be formed.
• 1 is a schematic overview of the structure of the device for generating two different radioactive isotopes
• Fig. 3 is a diagram illustrating the process steps that can be performed in the implementation of the method.
• Fig. 1 shows an overview of the device for generating two different radionuclides, one for SPECT imaging, another for PET imaging.
• the proton beam 11 is provided by an accelerator unit 13 such as a cyclotron and has ⁇ nearest a first energy of 15 MeV to 50 MeV.
• an accelerator unit 13 such as a cyclotron and has ⁇ nearest a first energy of 15 MeV to 50 MeV.
• the proton beam on a first target unit 15 is directed, which comprises a stack of Trustmateri ⁇ as that to be used for the SPECT imaging generated by interaction with the particle beam in a nuclear reaction, the 99 Mo / 99m Tc.
• a decoupling device 17 the first radioactive isotope 19 generated in the stack is extracted and collected, so that it is ready for further use.
• target material for the generation of m Tc can be Mo, so that 99m Tc results from the nuclear reaction 100 Mo (p, n) 99 Tc.
• the proton beam 11 is directed to a second Tar ⁇ get unit 21, in which there is a stack of the second starting material, which generates by interaction with the proton beam 11 in a further nuclear reaction, the radionuclide for PET imaging.
• the second radioactive isotope may be, for example, 11 C, 13 N, 18 F or 15 O.
• the second radioactive isotope 25 is just ⁇ if using a further decoupling device 23 removed from the second target unit 21 and collected so that it is ready for further use.
• the following table provides an overview of target materials and nuclear reactions that can be used to generate PET radionuclides.
• a first cross-section curve 31 identifies the first nuclear reaction induced by the particle beam in the first starting material.
• a second cross section curve 33 characterizes the second nuclear reaction, which is induced by the particle beam in the second starting material.
• Fig. 3 shows a schematic representation of the method ⁇ steps in one embodiment of the method.
• the particle beam is generated. This can be done by means of a cyclotron which generates a particle beam with always the same final energy (step 41).
• the particle beam is directed to a target comprising the first starting material (step 43).
• a first nuclear reaction is induced in which the first radioactive isotope is generated.
• the ra ⁇ diozine isotope produced is ge ⁇ gained by known Extension method (step 45).
• the decelerated particle beam is directed to a second target comprising a second source material (step 47).
• the second core radioactive isotope which is then recovered by well ⁇ te extraction process (step 49).

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• Physics & Mathematics (AREA)
• High Energy & Nuclear Physics (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Engineering & Computer Science (AREA)
• Chemical & Material Sciences (AREA)
• General Chemical & Material Sciences (AREA)
• General Engineering & Computer Science (AREA)
• Optics & Photonics (AREA)
• Plasma & Fusion (AREA)
• Spectroscopy & Molecular Physics (AREA)
• Nuclear Medicine (AREA)
• Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
• Radiation-Therapy Devices (AREA)
• Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

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• 2010
  • 2010-02-01 DE DE102010006433A patent/DE102010006433B4/de not_active Expired - Fee Related
• 2011
  • 2011-01-26 WO PCT/EP2011/051019 patent/WO2011092175A1/de active Application Filing
  • 2011-01-26 US US13/576,446 patent/US9287015B2/en not_active Expired - Fee Related
  • 2011-01-26 CN CN201180007969.6A patent/CN102741940B/zh not_active Expired - Fee Related
  • 2011-01-26 CA CA2788617A patent/CA2788617C/en not_active Expired - Fee Related
  • 2011-01-26 EP EP11701810A patent/EP2532008A1/de not_active Withdrawn
  • 2011-01-26 RU RU2012137198/07A patent/RU2549881C2/ru not_active IP Right Cessation
  • 2011-01-26 BR BR112012019102A patent/BR112012019102B1/pt not_active IP Right Cessation
  • 2011-01-26 JP JP2012550421A patent/JP2013518267A/ja active Pending

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