EP2528562B1 - Anzeige für eine augenchirurgiekonsole mit benutzerwählbaren sektoren - Google Patents
Anzeige für eine augenchirurgiekonsole mit benutzerwählbaren sektoren Download PDFInfo
- Publication number
- EP2528562B1 EP2528562B1 EP11769563.5A EP11769563A EP2528562B1 EP 2528562 B1 EP2528562 B1 EP 2528562B1 EP 11769563 A EP11769563 A EP 11769563A EP 2528562 B1 EP2528562 B1 EP 2528562B1
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- EP
- European Patent Office
- Prior art keywords
- display
- user
- surgical
- selectable
- phacoemulsification
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Classifications
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
- G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
- G16H40/63—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F9/00802—Methods or devices for eye surgery using laser for photoablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/13—Ophthalmic microscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/25—User interfaces for surgical systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/37—Surgical systems with images on a monitor during operation
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/40—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
- A61B2034/107—Visualisation of planned trajectories or target regions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/25—User interfaces for surgical systems
- A61B2034/258—User interfaces for surgical systems providing specific settings for specific users
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/37—Surgical systems with images on a monitor during operation
- A61B2090/371—Surgical systems with images on a monitor during operation with simultaneous use of two cameras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/20—Surgical microscopes characterised by non-optical aspects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
Definitions
- This application relates to ophthalmic surgical devices and, more particularly, to a display for an ophthalmic surgical console with user-selectable sectors.
- Various displays have been provided for ophthalmic surgical consoles. Such displays may frequently be overlaid on the surgical microscope used to view the eye. Unfortunately, these displays frequently suffer from several drawbacks. First, the displays can often be inconveniently placed, obscuring the surgeon's view of the eye and creating a tradeoff between the additional information provided in the display and clear vision of the surgical field. Second, including additional information in the display can make the display crowded and less usable. Third, the displays frequently use ring-shaped patterns, often including measurement scales. Such patterns can be distracting to the surgeon without being sufficiently visible for the surgeon to easily use them. Accordingly, there is a need in the art for an improved display for ophthalmic surgical consoles.
- an ophthalmic surgical system includes a display device and a user interface.
- the display device generates a display on an image of a patient's eye comprising a plurality of non-overlapping display sectors. Each display sector displays one of a plurality of user-selectable surgical parameters.
- a user interface receives a user selection of one or more of the user-selectable surgical parameters to be displayed.
- a method of displaying surgical parameters on an ophthalmic surgical system includes receiving a selection of at least two user-selectable surgical parameters. The method further includes generating a display on an image of a patient's eye comprising a plurality of non-overlapping display sectors. Each display sector displays one of the plurality of user-selectable surgical parameters
- FIG. 1 illustrates an ophthalmic surgical system 100 according to a particular embodiment of the present invention.
- the system 100 includes surgical instrumentation 102, a user interface 104, and a surgical microscope 106.
- Surgical instrumentation 102 may include any type of component or machine used in ophthalmic surgery, including but not limited to handpieces, pneumatic systems, laser sources, illumination sources. Such components may be used in ophthalmic surgical techniques such as phacoemulsification, vitreoretinal surgery, laser refractive surgery, or any of the other various ophthalmic surgical methods known to one skilled in the art.
- the user interface 104 may include any kind of keyboard, switch, knob, pedal, button, pointing device, or other suitable component for receiving selections of surgical parameters from the user.
- the surgical microscope 106 may include any manner of optical or electronic device or collection of components providing a view of a patient's eye to the surgeon.
- Surgical instrumentation 102 operates under the control of a processor 108; it also has memory 110 storing surgical parameter information.
- the processor 108 may be any microprocessor, microcontroller, programmable element, or other device or collection of devices for processing instructions for the control of surgical instrumentation 102.
- the processor 108 receives parameter selections from the user interface 104 and controls the operation of surgical parameters accordingly.
- the processor 108 also monitors surgical parameters during surgery.
- the memory 110 may be any suitable form of volatile or non-volatile information storage accessible by processor, including but not limited to optical, electronic, or magnetic media.
- Various embodiments of surgical systems according to the present invention further include a display device 200.
- the display device 200 includes any suitable optical or electronic components or collection thereof capable of generating a visually-perceptible display of surgical parameters on an image of the patient's eye.
- the display device 200 can project light onto a surface of the patient's eye to generate an image that is captured by the surgical microscope 106 along with the image of the eye.
- the display device 200 can project the display into an optical path of the surgical microscope 106 to produce the display over an image of the eye.
- Such embodiments may allow the display to be focused or magnified along with the image of the eye as well; alternatively, they may allow the display and the eye image to be focused or sized independently.
- the display device 200 can be incorporated into an eyepiece of the surgical microscope 106.
- the display device 200 may be configured to communicate with and/or share the processor 108 and/or the memory 110 in order to allow the surgical parameter display to be adjusted based on user selection of surgical parameters and variation of those parameters in real time during surgery.
- FIG. 2 illustrates an example display 202 according to particular embodiments of the present invention.
- the display 202 includes a number of display sectors 204A, 204B, ... 204n, which will be generally referred to herein as display sectors 204.
- the term "display sectors" refers to the fact that these portions of the display fall within a sector of a circle centered at the center of display with the sector having a central angle less than 180 degrees.
- the display sectors are non-overlapping, which is to say that any quantitative portion of the display for any one surgical parameter does not extend circumferentially into another display sector 204 displaying a different surgical parameter.
- purely visual elements unrelated to the surgical parameters or measurements such as the arcs showing the inner edge of the display, may extend circumferentially without being considered “overlapping,” so long as the quantitative display of the surgical parameters does not extend into another display sector 204.
- the display 202 may be customized according to user-selectable surgical parameters.
- particular elements of the surgical parameter display may be further customized based on user preference.
- the user may select from a variety of phacoemulsification and/or vitrectomy surgical parameters, including but not limited to power level, vacuum pressure for phacoemulsification, bottle height for irrigation solution, aspiration, footswitch position, phacoemulsification step and occlusion indicator.
- the user may also select minimum or maximum display values for ranged surgical parameters and displays with analog or digital values. Separating the display 202 into non-overlapping sectors 204 that can be individually selected and adjusted prevents the display 202 from becoming undesirably crowded, while still maintaining all of the information that the surgeon desires in an easily viewed format.
- the surgical parameters can include any relevant operating parameter for the surgical instrumentation that is selected by the user and that is monitored or selected during surgery.
- the quantitative display of the parameter can be a number, a range, and on-off or other binary indicator, or any suitable visible element or combination of elements conveying relevant parameter information.
- real-time values can be shown on a variable gauge.
- Such gauges may include moving needles, bars with length that varies based on the value (e.g., vertical, horizontal, circumferential, radial), or bubble gauges, such as the ones illustrated in Figure 2 .
- Multiple display formats may also be user-selectable.
- Colored elements may also be used in the display 202 to improve visibility, contrast, and the like.
- a lighted green display taking the form illustrated in Figure 2 would be easily visible when superimposed on the eye image.
- Gauges could also change color, such as changing to red when a parameter moves to an unacceptable range, when a laser source is active, or when some other notification to the surgeon might be required.
- the display 202 may also include one or more axes to indicate directions on the display.
- the display 202 may include the target axis for astigmatic correction when a toric lens is being implanted.
- the axis could indicate a desired incision line for lens implantation. Because the numerical and/or measurement scale displays of such lines do not extend circumferentially across sectors, they are also considered "non-overlapping" for purposes of this specification. Consequently, the incorporation of such visual elements should not be considered for purposes of determining the non-overlapping display sectors 204.
- Figure 3 shows an example selection screen 300 that can be used in conjunction with an ophthalmic surgical system 100.
- the selection screen 300 confirms the procedure to be performed with the surgical instrumentation 102, the surgeon, and the patient on whom the procedure will be performed.
- the selection screen 300 also displays values for surgical parameters.
- the screen can allow selection of value ranges for the parameters, different parameters, etc., so that the user can appropriately configure the display 202 in advance of the surgical procedure.
- Figure 4 is a flow chart showing an example method for displaying surgical parameters according to the present invention.
- a selection screen is provided permitting selection of surgical parameters to be displayed.
- a selection of surgical parameters to be displayed is received.
- the selection of surgical parameters may include, for example, which parameters will be displayed, what the display format will be, what range of various surgical parameters will be displayed, and the like.
- the surgical parameters are displayed on non-overlapping display sectors.
- the surgical parameters are monitored during the surgical procedure.
- the display is updated based on a change in the surgical parameters. Steps 408 and 410 may be continuously performed until the surgical procedure is complete, as shown by decision step 412, at which time the method is at an end.
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- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Ophthalmology & Optometry (AREA)
- Oral & Maxillofacial Surgery (AREA)
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- Gynecology & Obstetrics (AREA)
- Radiology & Medical Imaging (AREA)
- Human Computer Interaction (AREA)
- Biophysics (AREA)
- Primary Health Care (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Business, Economics & Management (AREA)
- General Business, Economics & Management (AREA)
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- Microscoopes, Condenser (AREA)
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Claims (13)
- Ophthalmisches Chirurgiesystem (100), aufweisend:eine Anzeigevorrichtung (200) betreibbar zum Erzeugen einer ÜberlagerungsAnzeige (202) auf einem Bild eines Auges eines Patienten, wobei die Anzeigevorrichtung (200) dazu adaptiert ist, die Anzeige in den optischen Gang eines chirurgischen Mikroskops (106) zu projizieren,eine Anwenderschnittstelle (104) betreibbar zum Empfangen einer Anwender-Auswahl von einem oder mehreren anwenderwählbaren chirurgischen Parametern, die es anzuzeigen gilt,dadurch gekennzeichnet, dass die Anzeigevorrichtung betreibbar ist, um auf einem Bild eines Patienten-Auges eine Mehrzahl an sich nicht überlappenden Anzeigesektoren (204) anzuzeigen (202), die innerhalb eines Sektors eines Kreises fallen, der im Zentrum der Anzeige zentriert ist, wobei jeder Sektor einen Parameter aus einer Mehrzahl der anwenderwählbaren Phakoemulsifikations-und/oder vitrektomie-chirurgischen Parametern anzeigt.
- System nach Anspruch 1, wobei die Anzeige (202) ferner entweder eine Zielachse zum Ausrichten einer torischen Linse oder Einschnitt-Führung aufweist.
- System nach Anspruch 1, wobei die anwenderwählbaren Phakoemulsifikations- und/oder vitrektomie-chirurgischen Parameter einen Unterdruck oder ein Leistungslevel aufweisen oder eine Aktivität einer Laserquelle aufzeigen.
- System nach Anspruch 1, wobei zumindest ein Parameter der anwenderwählbaren Phakoemulsifikations- und/oder vitrektomie-chirurgischen Parameter als variables Maß, optional als Druckmaß angezeigt wird.
- System nach Anspruch 1, wobei die Anzeigevorrichtung (200) dazu adaptiert ist, eine beleuchtete Anzeige anzuzeigen.
- System nach Anspruch 1, wobei die Anzeigevorrichtung (200) dazu adaptiert ist, die Anzeige (202) auf das Auge des Patienten zu projizieren.
- Computerimplementiertes Verfahren zum Anzeigen von chirurgischen Parametern auf einem ophthalmischen chirurgischen System gemäß Anspruch 1, umfassend:Empfangen (404) einer Auswahl von mindestens zwei anwenderwählbaren Phakoemulsifikations- und/oder vitrektomie-chirurgischen Parametern von einer Anwenderschnittstelle; unddie Anzeigevorrichtung generiert (406) eine Überlagerungsanzeige (202) auf einem Bild eines Patienten-Auges umfassend eine Mehrzahl an sich nicht überlappenden Anzeigesektoren (204), die innerhalb eines Kreises fallen, der im Zentrum der Anzeige zentriert ist, wobei jeder Anzeigesektor einen aus der Mehrzahl der anwenderwählbaren Phakoemulsifikations- und/oder vitrektomie-chirurgischen Parametern anzeigt.
- Verfahren nach Anspruch 7, ferner umfassend ein Anzeigen einer Selektionsmaske (300) an den Anwender.
- Verfahren nach Anspruch 7, wobei die Anzeige (202) ferner eine Zielachse zum Ausrichten einer torischen Linse oder Einschneid-Führung aufweist.
- Verfahren nach Anspruch 7, wobei die anwenderwählbaren Phakoemulsifikations- und/oder vitrektomie-chirurgischen Parameter einen Unterdruck oder ein Leistungslevel aufweisen oder eine Aktivität einer Laserquelle aufzeigen.
- Verfahren nach Anspruch 7, wobei mindestens ein Parameter der anwenderwählbaren Phakoemulsifikations- und/oder vitrektomie-chirurgischen Parameter als ein variable Maß, optional als ein Druckmaß angezeigt wird.
- Verfahren nach Anspruch 7, wobei die Anzeigevorrichtung (200) dazu adaptiert ist, eine beleuchtete Anzeige wiederzugeben.
- Verfahren nach Anspruch 7, wobei die Anzeigevorrichtung dazu adaptiert ist, die Anzeige auf das Auge des Patienten zu projektieren.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32409610P | 2010-04-14 | 2010-04-14 | |
| PCT/US2011/032432 WO2011130477A1 (en) | 2010-04-14 | 2011-04-14 | Display for ophthalmic surgical console with user-selectable sectors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP2528562A1 EP2528562A1 (de) | 2012-12-05 |
| EP2528562A4 EP2528562A4 (de) | 2013-07-31 |
| EP2528562B1 true EP2528562B1 (de) | 2015-12-30 |
Family
ID=44788760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP11769563.5A Active EP2528562B1 (de) | 2010-04-14 | 2011-04-14 | Anzeige für eine augenchirurgiekonsole mit benutzerwählbaren sektoren |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9149340B2 (de) |
| EP (1) | EP2528562B1 (de) |
| JP (2) | JP2013523409A (de) |
| CN (1) | CN102834079B (de) |
| AR (1) | AR084679A1 (de) |
| AU (1) | AU2011239657B2 (de) |
| BR (1) | BR112012026133A2 (de) |
| CA (1) | CA2791096C (de) |
| ES (1) | ES2559039T3 (de) |
| RU (1) | RU2584389C2 (de) |
| TW (1) | TWI522085B (de) |
| WO (1) | WO2011130477A1 (de) |
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| JP6236882B2 (ja) * | 2013-06-03 | 2017-11-29 | 株式会社ニデック | レーザ治療装置 |
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| EP3374899A1 (de) * | 2015-11-11 | 2018-09-19 | Johnson & Johnson Surgical Vision, Inc. | Systeme und verfahren zur bereitstellung eines virtuellen zugriffs auf eine chirurgische konsole |
| US10426339B2 (en) * | 2016-01-13 | 2019-10-01 | Novartis Ag | Apparatuses and methods for parameter adjustment in surgical procedures |
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| US11722644B2 (en) | 2018-09-18 | 2023-08-08 | Johnson & Johnson Surgical Vision, Inc. | Live cataract surgery video in phacoemulsification surgical system |
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-
2011
- 2011-04-13 TW TW100112793A patent/TWI522085B/zh not_active IP Right Cessation
- 2011-04-14 US US13/086,509 patent/US9149340B2/en active Active
- 2011-04-14 ES ES11769563.5T patent/ES2559039T3/es active Active
- 2011-04-14 EP EP11769563.5A patent/EP2528562B1/de active Active
- 2011-04-14 AU AU2011239657A patent/AU2011239657B2/en active Active
- 2011-04-14 AR ARP110101290A patent/AR084679A1/es unknown
- 2011-04-14 RU RU2012148266/14A patent/RU2584389C2/ru not_active IP Right Cessation
- 2011-04-14 WO PCT/US2011/032432 patent/WO2011130477A1/en not_active Ceased
- 2011-04-14 CA CA2791096A patent/CA2791096C/en active Active
- 2011-04-14 JP JP2013505128A patent/JP2013523409A/ja not_active Withdrawn
- 2011-04-14 CN CN201180018626.XA patent/CN102834079B/zh active Active
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|---|---|
| RU2012148266A (ru) | 2014-05-20 |
| CA2791096A1 (en) | 2011-10-20 |
| CN102834079B (zh) | 2016-05-25 |
| TWI522085B (zh) | 2016-02-21 |
| AR084679A1 (es) | 2013-06-05 |
| CN102834079A (zh) | 2012-12-19 |
| ES2559039T3 (es) | 2016-02-10 |
| US20150359673A1 (en) | 2015-12-17 |
| US20110257638A1 (en) | 2011-10-20 |
| EP2528562A1 (de) | 2012-12-05 |
| BR112012026133A2 (pt) | 2016-06-28 |
| US10238538B2 (en) | 2019-03-26 |
| CA2791096C (en) | 2019-05-21 |
| US9149340B2 (en) | 2015-10-06 |
| JP2016127962A (ja) | 2016-07-14 |
| WO2011130477A1 (en) | 2011-10-20 |
| AU2011239657A1 (en) | 2012-09-13 |
| JP6077687B2 (ja) | 2017-02-08 |
| RU2584389C2 (ru) | 2016-05-20 |
| AU2011239657B2 (en) | 2015-06-04 |
| EP2528562A4 (de) | 2013-07-31 |
| JP2013523409A (ja) | 2013-06-17 |
| TW201138716A (en) | 2011-11-16 |
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