EP2514372A1 - Instrumentarium zum Einsetzen einer Gelenkprothese, insbesondere Knieprothese - Google Patents

Instrumentarium zum Einsetzen einer Gelenkprothese, insbesondere Knieprothese Download PDF

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Publication number
EP2514372A1
EP2514372A1 EP11163566A EP11163566A EP2514372A1 EP 2514372 A1 EP2514372 A1 EP 2514372A1 EP 11163566 A EP11163566 A EP 11163566A EP 11163566 A EP11163566 A EP 11163566A EP 2514372 A1 EP2514372 A1 EP 2514372A1
Authority
EP
European Patent Office
Prior art keywords
guide
receptacle
instrumentarium
instrumentarium according
insert
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP11163566A
Other languages
German (de)
English (en)
French (fr)
Inventor
Balzarini Amos
Marco Iredi
Klaus Dmuschewsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deru GmbH
Original Assignee
Deru GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deru GmbH filed Critical Deru GmbH
Priority to EP11163566A priority Critical patent/EP2514372A1/de
Priority to BR112013026871-9A priority patent/BR112013026871B1/pt
Priority to ES12715109.0T priority patent/ES2551391T3/es
Priority to RU2013150699A priority patent/RU2607957C2/ru
Priority to PCT/EP2012/057163 priority patent/WO2012143444A1/de
Priority to US14/113,092 priority patent/US9855061B2/en
Priority to KR1020137030764A priority patent/KR101965005B1/ko
Priority to HUE12715109A priority patent/HUE026159T2/en
Priority to MX2013012169A priority patent/MX343887B/es
Priority to PT127151090T priority patent/PT2699171E/pt
Priority to UAA201313466A priority patent/UA113624C2/uk
Priority to JP2014505627A priority patent/JP6047554B2/ja
Priority to PL12715109T priority patent/PL2699171T3/pl
Priority to AU2012244702A priority patent/AU2012244702B2/en
Priority to CA2833294A priority patent/CA2833294C/en
Priority to CN201280030655.2A priority patent/CN103781427B/zh
Priority to EP12715109.0A priority patent/EP2699171B1/de
Publication of EP2514372A1 publication Critical patent/EP2514372A1/de
Priority to IL228940A priority patent/IL228940A/en
Priority to CO13271971A priority patent/CO6852035A2/es
Priority to ZA2013/08715A priority patent/ZA201308715B/en
Priority to HK14108531.3A priority patent/HK1194951A1/zh
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/16—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans
    • A61B17/1662—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans for particular parts of the body
    • A61B17/1675—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans for particular parts of the body for the knee
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/16—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans
    • A61B17/17—Guides or aligning means for drills, mills, pins or wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/14—Surgical saws ; Accessories therefor
    • A61B17/15—Guides therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/14—Surgical saws ; Accessories therefor
    • A61B17/15—Guides therefor
    • A61B17/154—Guides therefor for preparing bone for knee prosthesis
    • A61B17/155—Cutting femur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/16—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans
    • A61B17/17—Guides or aligning means for drills, mills, pins or wires
    • A61B17/1739—Guides or aligning means for drills, mills, pins or wires specially adapted for particular parts of the body
    • A61B17/1764—Guides or aligning means for drills, mills, pins or wires specially adapted for particular parts of the body for the knee
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/14—Surgical saws ; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/14—Surgical saws ; Accessories therefor
    • A61B17/142—Surgical saws ; Accessories therefor with reciprocating saw blades, e.g. with cutting edges at the distal end of the saw blades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/14—Surgical saws ; Accessories therefor
    • A61B17/142—Surgical saws ; Accessories therefor with reciprocating saw blades, e.g. with cutting edges at the distal end of the saw blades
    • A61B17/144—Surgical saws ; Accessories therefor with reciprocating saw blades, e.g. with cutting edges at the distal end of the saw blades with cutting edges at the side of the saw blades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/14—Surgical saws ; Accessories therefor
    • A61B17/15—Guides therefor
    • A61B17/154—Guides therefor for preparing bone for knee prosthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/16—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans
    • A61B17/1613—Component parts
    • A61B17/1615—Drill bits, i.e. rotating tools extending from a handpiece to contact the worked material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/16—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans
    • A61B17/164—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans intramedullary
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/16—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans
    • A61B17/1642—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans for producing a curved bore
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/16—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans
    • A61B17/1659—Surgical rasps, files, planes, or scrapers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/16—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans
    • A61B17/17—Guides or aligning means for drills, mills, pins or wires
    • A61B17/1735—Guides or aligning means for drills, mills, pins or wires for rasps or chisels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/16—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans
    • A61B2017/1602—Mills
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/03—Automatic limiting or abutting means, e.g. for safety
    • A61B2090/033—Abutting means, stops, e.g. abutting on tissue or skin
    • A61B2090/034—Abutting means, stops, e.g. abutting on tissue or skin abutting on parts of the device itself

Definitions

  • the invention relates to an instrument for inserting a joint prosthesis, in particular a femoral component of a knee prosthesis, at the end of a bone, in particular of the femur.
  • the present invention has the object to provide an improved instrumentation, which allows a more precise implantation.
  • the invention provides a base frame, which has a guide plate and a side protruding therefrom primary teaching, a fastening device for positionally fixed arrangement the base frame on the bone, a Bogenfräslehre with a base body and a guide piece, wherein the guide along a curved guide track relative to the base body is movable and it has a receptacle for a Abtragtechnikmaschine, and an aligning device which the Bogenfräslehre when inserted into the base plate in a clearly defined relative position sets.
  • the invention is based on the idea, by means of a base frame, which is positioned in a conventional manner in a fastening device on the bone to provide a stable and highly accurate by means of the alignment device platform on which the Bogenfräslehre is easy to use, and thereby automatically and safely is precisely aligned.
  • the Bogenfräslehre has a curved guideway along which a corresponding rounded shape of the bone can be done by means of the Abtragwerkmaschines. This is particularly suitable for the preparation of a receiving seat for condylar components of the knee joint prosthesis.
  • a wall-like bone residue can be left standing on Patellaschild so in knee joint prosthesis, which not only provides a basis for the patellar lateral support of the joint prosthesis, but also serves as a frontal delimitation of the box-shaped cavity of the medullary cavity for receiving the main body of the prosthesis.
  • the invention enables a precisely defined removal of bone material on the basis of a clean basic positioning, whereby even complicated shapes, such as the varying curvature of the condyles in a knee joint, can be worked out in a simple and accurate position.
  • the geometry is preferably selected such that the respective center of curvature remains in a plane across the non-constant curvature along the guideway, whereby it shifts in the horizontal direction from anterior to posterior (preferably 10 mm, maximum 20 mm).
  • the guide piece in which the removal tool is received is expediently mounted pivotably on the base body via a follower with the guide track as well as via a rotary bearing.
  • a follower With this double bearing both the rotation of the guide piece along the guideway is controlled, as well as its orientation relative to the guideway.
  • both the radius of curvature and the position of the center of curvature can be accurately controlled. It has proven particularly useful if the rotary bearing is arranged at a distance from the follower and has a toggle lever pivotably mounted on both sides. This results in a space-saving kinematics, which also linked precise leadership with avoiding jamming.
  • the toggle lever is detachably mounted on the base body via a fuse.
  • This makes it possible to use the Bogenfräslehre with their base separately in the base plate, without being hindered by the movable over a large adjustment range guide. This is not just a simplification but allows for better handling. This is especially true in the case when, due to low tolerances, the insertion of the Bogenfräslehre is difficult, the force required for this can optionally be applied with a hammer. Thanks to the removability of the guide then there is no risk during the driving of the body to damage the decisive for accurate positioning guide with its guideway.
  • a quick coupling between the guide piece and the base body is expediently provided.
  • An extension here means a region of the guideway that is not required for the actual shaping by means of the removal tool (but represents an unused additional area, so to speak).
  • the angle lock comes in such a position that it can be easily and without tools separated.
  • the assembly which can be done easily and without tools in the same way.
  • the guide only needs to be brought into the extreme position in the extension, to be separated or replaced.
  • the angle lock may consist of a rotary bearing sleeve and a non-circular pivot, which is designed so that the angle lock opens only in an angular position of the guide. This is achieved in such a way that the rotary bearing sleeve is open over a narrowing to one side.
  • the non-circular pivot pin is designed so that it has different widths depending on the positioning. This width in a particular positioning is called the width in a given meridian.
  • the non-circular pivot pin has such a shape that substantially corresponds to a rectangle with short arcuate sides
  • the width in the smallest width meridian equals the distance between the two long sides of the rectangle
  • the width corresponding to the meridian largest width equal to the length of the longer side of the rectangle plus the bulges through the arcuate short sides.
  • the toggle lever is preferably also detachably mounted on the base body. This makes it possible to remove all moving parts. This is not only beneficial for the cleaning of the instruments, but also, as already stated, for the assembly of the body in difficult cases, without causing damage to the sensitive guides.
  • the holder of the toggle lever via a fuse, so that it is protected against unintentional release from the intended position. As a backup in particular a screw has proven.
  • the guide piece which is movable along the guideway, defines an axis for the removing tool through its reception.
  • the axis may be oriented so that it lies in the pivoting plane of the guide piece, but preferably it is skewed. Further preferably, this axis is also skewed to the line between follower and rotary bearing.
  • the receptacle for the removal tool on the guide piece cooperates with a depth stop.
  • Depth stop is here understood to mean a device which limits the penetration depth of the removal tool into the workpiece, in this case the bone on which the instrumentation according to the invention is used.
  • the lateral opening ensures that the ablation tool can be inserted directly from the side into the receptacle, without the need for awkward threading.
  • the Abtragwerkmaschine can be implemented after a condyle is formed, so as to form the second condyle at the other position. Dismantling or converting the Bogenfräslehre is not required, so that the precise positioning is maintained.
  • the double recording is not absolutely necessary.
  • the guide piece with the rotary bearing and optionally with the knee lever from one side of the body to the other is remountable.
  • the condyle can first be prepared on one side, and after being mounted on the other side, the other condyle can be prepared with the same receptacle on the guide piece. Since in this case the positioning of the Bogenfräslehre need not be changed with their body itself, the precise positioning is maintained.
  • fastening holes are provided on the main body and / or the guideway. They allow to secure the positioning of the Bogenfräslehre, regardless of their inclusion in the base plate. Thus, the fastening security and thus ultimately the quality of the position accuracy are increased; In particular, it is possible to remove the base frame.
  • an alignment insert can be provided replaceably on the base frame, which is designed to receive an alignment body in a defined position.
  • the alignment body can in particular be a bone clearing tool, in particular an awl or a rasp for opening the medullary canal.
  • the guide described in the preceding paragraphs will usually be designed so that the receptacle for the removal tool is oriented with its axis so that the axis has a radial orientation. This means that it is essentially directed to the center of curvature. Alternatively, however, it can also be provided that the axis is oriented transversely to the plane defined by the curvature.
  • both condylar forms can thus be formed on a femur with a movement along the guideway.
  • the guide piece with the rotary bearing and, where appropriate, the toggle lever from one side of the body to the other is ummontierbar.
  • the removal tool is dimensioned such that only one condylar path, namely the respectively closest one, is formed.
  • mounting holes may conveniently be provided on the base body and / or the guideway. They serve primarily as a substitute for the attachment by means of the alignment device to the base frame anchored in the bone, so that the base frame can be removed if necessary.
  • an ensemble of inserts are provided for the base frame, which are changeable in the guide plate can be accommodated.
  • This is in particular an alignment insert, a frontal saw insert, a first milling insert, a second milling insert and a third milling insert with a slotted guide.
  • the alignment insert is adapted to be arranged to be changeable in a defined position on the guide plate, wherein it has a receptacle for the alignment body.
  • the base plate can be uniquely positioned with respect to the alignment body.
  • the alignment insert is side-dependent, that is, there is an alignment insert "L” for implantation of the left-sided prosthesis and an alignment insert "R” for implantation of a right-side prosthesis. It should be noted that, as supplements, it is additionally possible to provide a symmetrical auxiliary alignment insert that can be used in the same way on both sides.
  • the receptacle for the alignment body on the alignment insert is expediently open on one side. This is preferably accomplished by means of a constriction. This ensures that the alignment body (usually this is an inserted into the medullary cavity of the bone instrument, such as an awl or a milling cutter act) can be easily inserted from the side into the receptacle or removed from this ,
  • the ensemble of inserts includes a frontal saw insert.
  • This has two V-shaped aligned Sgellitze and a bipolar attachment.
  • bipolar attachment is meant a fixation defining two alternative attachment positions. These attachment positions are selected so that the saw slots are arranged once for implantation of a left-sided prosthesis and in the other case for implantation of a right-side prosthesis.
  • An expedient embodiment for such a bipolar attachment may be two individual attachment holes, or preferably a slot whose endpoints define the respective bipolar attachment positions.
  • the instrumentation further comprises spacers for different heights, which are designed for two-sided arrangement at the edge of the guide plate. With the spacers, a certain distance of the guide plate to the bone can be adjusted. This is particularly suitable for those cases where bone has already been removed as a result of previous surgery. In this way, the loss of material can be compensated.
  • spacers of different dimensions are included in the instrumentation.
  • the ensemble comprises a first milling insert, which is changeable in the guide plate attachable. It forms a defined receptacle for a broach, which preferably also forms a depth stop for the Räumfräser. This ensures accurate execution of the milling. In particular, this ensures that the Räumfräser does not migrate to the side and thus laterally or frontally or dorsally in an undesirable manner removes bone material. With The depth stop further ensures that bone material is removed only at the depth required for implantation.
  • the distance of the receptacle to the primary gauge is dimensioned such that when the broaching cutter is inserted a distance remains which corresponds to the thickness of a wall to be left on the frontal side of the patellar plate. This is possible thanks to the forced guidance of the broach cutter, even in a confusing operating environment, even a less experienced surgeon.
  • the instrumentation further comprises a feeler gauge, which can be attached at a plug-in receptacle to the base frame with angular accuracy.
  • a feeler gauge By means of this feeler gauge, the position of the pivot point of the prosthesis can be displayed, preferably in two planes of orientation.
  • the ensemble comprises a second milling insert, which is changeable attachable to the guide plate.
  • This has a double receptacle for the replaceable recording of a volume cutter.
  • the double receptacle is preferably designed such that it has different depth stops and also a lateral offset.
  • lateral displacement is understood to mean that the volume milling cutter is positioned differently in the one position of the double receptacle in the lateral-medial direction than in the other position of the double receptacle.
  • the double receptacle is preferably designed such that their areas overlap.
  • the second milling insert may also be an auxiliary milling insert which likewise has a double receptacle.
  • this double receptacle is simplified in the sense that it preferably has identical deep stops and / or has no lateral offset. This can be used to produce simpler structures for the cavity.
  • This auxiliary milling insert is particularly useful if only a relatively small cavity needs to be worked out.
  • the ensemble further includes a third milling insert attachable to the guide plate.
  • This forms a slotted guide for a depth cutter, which is preferably received in a slotted guide.
  • a fine shaping of the cavity can be achieved by means of the depth cutter.
  • the scenery limits the movement of the depth cutter in the lateral-medial direction.
  • the gate slider has a handle which coaxially surrounds the depth cutter. This allows a more precise guidance of the depth cutter can be achieved.
  • the slotted guide may have additional windows for visual control of the milling.
  • the slotted guide has a depth stop.
  • a second depth milling cutter can be provided, so defined by two different cutting depths are. This allows a secure and more precise development of even complex cavities.
  • the slotted guide comprises two guide levers pivotally connected to one another.
  • the receptacle for the depth cutter can be arranged at one end, while at the other end of the articulated guide lever pivotally mounted on the insert is provided in the guide plate.
  • this embodiment can have an advantage that a risk of jamming is reduced.
  • the bearing on the insert is designed so that the articulated guide levers are only placed or separable when the Frästechnikinstrument is not used.
  • an insertion guide is provided on the guide plate, which is designed in particular as a dovetail guide.
  • the various inserts of the ensemble, as described above, can be easily inserted and precisely positioned with respect to the guide plate.
  • the instrumentation also includes advantageously a setting tongs for the Bogenfräslehre.
  • the instrumentation expediently comprises remote alignment rods for lateral arrangement on the base frame in such a way that they point away from one another.
  • Alignment holes are provided on lateral sides of the base frame for mounting these alignment bars.
  • the instrumentation includes a drill with a depth stop. He is trained to create positionally accurate and easy way on the bone recordings for Anankerunszapfen the endoprosthesis.
  • the instrument also includes various awls for clearing a cavity on the bone, especially a medullary cavity on the femur.
  • it expediently comprises a rasp broach whose shaft has a recess. This is designed to receive a stop plate, which acts in particular as a depth stop.
  • the rasp broach is expediently designed so that it has 2, 3 or 4 cutting edges.
  • the teeth are arranged on the cutting edges with a relative height offset from each other. This causes the teeth to remove bone material at different points during rotation, resulting in a smoothing of the bone surface.
  • the instrument expediently further comprises a straightening gauge, which is provided for positioning the base plate and engages the alignment device.
  • a straightening gauge which is provided for positioning the base plate and engages the alignment device.
  • it is designed to be in the medullary canal sticking rasp broach, and thus to position the base plate exactly in relation to this.
  • instrumentation for implantation of a knee joint endoprosthesis includes two awls 90, 91 (s. FIG. 14 ) and a rasp broach 92 (s. Fig. 2 ), a base frame 1, pins 99 as a fastening device on a femur bone, an alignment insert 3, a frontal saw insert 40, spacers 34, a feeler gauge 39, a first milling insert 4, a second milling insert 5, a third milling cutter Insert 6 as a slotted guide, and a Bogenfräslehre 7 with a Kondylenfräser 79th
  • the base frame 1 comprises a guide plate 12 and one of them orthogonal laterally projecting primary gauge 11.
  • a first saw blade guide 20 which serves to compensate for different condyle heights
  • a second saw blade guide 21 which is for processing the Condyle when using femoral segments is used.
  • holes 22 are formed for fastening pins in the area between the saw blade guides.
  • aligned mounting holes 26 are provided for spacers in the direction of extension of the guide plate.
  • the base frame 1 is provided in various sizes. Here, the distance between the reference plane 10 and the Saw blade guides 20, 21 and to the mounting holes 26 to the spacers identical for the different sizes.
  • the guide plate 12 is designed with its underside as a reference plane 10. This serves as a contact surface to condyles of the femur.
  • the tool level 14 acts. It is the reference plane for the various inserts that are received on the guide plate 12. In this case, the dimension between the reference plane 10 and the tool plane 14 is matched to the respective size of the implant to be used.
  • a linear guide 2 is arranged, which comprises two undercut edges between the tool plane 14 and the top of the guide plate 12. They act as a dovetail guide for the inserts 3, 4, 5 and 6.
  • each have a milled recess 15 is formed on the lateral sides. It is designed so deep that the width remaining between them corresponds to the width of the width of the implant associated with the respective base plate 1.
  • the milled recess 15 thus acts as a visual aid for selecting the implant sizes.
  • each have an alignment hole 23 is provided with an internal thread, which indicates the position by means of an alignment rod 38 to be screwed. Flanking the milled holes 15 holes 28 are provided for mounting pins 99.
  • a central opening of an approximately rectangular basic shape is formed, which at its two lateral side facing lateral surfaces as a lateral boundary 66 and with their remote from the primary gauge edge 65 as a rear boundary for a box milling works.
  • guide slots 17 are formed for a Einsetzinstrument 76 of the Bogenfräslehre 7.
  • drill guides 18 for a pinhole bore are provided on both sides in the guide plate 12.
  • a posterior saw blade guide 19 is designed for Kondylenbearbeitung.
  • a diagonal alternating guide 16, 16 'oriented parallel to this is formed in the end facing the primary gauge 11.
  • a central fastening 14 is centrally provided on the base plate 12. It serves to fasten the individual inserts. It is always in the same position for the different sizes on the base frame 1, so that the different inserts can be easily used with base frame 1 of different sizes. On both sides thereof free working 29 are formed, which create the necessary space for mounting pins on the Bogenfräslehre 7 to their attachment to the femur.
  • the rasp scraper indicated generally by reference numeral 92, includes a plurality of cutting edges 93 in its lower portion, each provided with a plurality of teeth 94. To those provided with the teeth 94 Cutting edges 93 adjoin upwardly a tooth-free region 95 of reduced diameter. Above this, a recess 96 is formed. This serves as a receptacle for a stop plate 97.
  • the cutting edges 93 are preferably designed in a triangular configuration, which means there are three cutting edges 93 which are arranged at an angular distance of 120 °. It should be noted that a different number of cutting edges, in particular two cutting edges or four cutting edges could also be provided (see illustrations in FIG Fig. 2b ). At the in Fig.
  • the arrangement of the teeth 94 is selected so that the teeth 94 of a cutting edge 93 are offset in height from the tip of the rasp broach 92 to teeth 94 'of the adjacent cutting edge 93'.
  • This has the advantage that with the rotation of the rasp broach 92 a more uniform design of the bone wall is achieved. It is specifically designed to preserve the bone in the near-edge area. For this she has a flattening, with which she is oriented to the bone. After insertion into the depth of the medullary cavity and rasping, it is then used as a reamer.
  • the rasp broach 92 functions with its upper shaft region above the groove 96 as an alignment aid and acts together with the alignment insert 3.
  • This has an opening 31 which is open via a constriction 31 'to the side.
  • the rasp broach 92 with its recess 96 can be introduced into the opening 31 by being inserted through the constriction 31 '.
  • the alignment rods 38 are in the alignment holes 23 screwed in and show the surgeon the position of the base frame and thus act as an alignment aid.
  • the opening 31 is not oriented orthogonal to the reference plane 10, but is at an angle to her.
  • the deviation from the orthogonal direction is referred to as the shank angle ⁇ and a characteristic measure of the prosthesis (6 degrees in the example).
  • an opening 30 is further formed on the alignment insert 3, which is formed on a projecting beyond the front boundary of the base plate 1 tongue through this opening 30 is a stylus 30 'inserted, which outside the Femur is to be machined and the surgeon thus indicates the shaft angle of the rasp in the medullary space of the femur to be machined rasp 92 (see Fig. 1e and f).
  • the alignment insert 3 is chamfered in a wedge-like manner on its lateral sides 33 (wedge angle ⁇ is 4 to 10 degrees, preferably 6 degrees), at least by the shank angle ⁇ . This results on the one hand a sufficiently accurate positioning in the linear guide 2, and on the other hand - unlike a real dovetail guide - the use are taken upwards, at the end of the alignment process (s. Fig. 14 ).
  • a pre-processing a cavity in the medullary cavity of Femur can be made (s. Fig. 16 ).
  • the broaching cutter 36 is tilted by the same shank angle ⁇ as the rasp broaching tool 92. This makes it possible to mill a deep area for the stem of the prosthesis.
  • the maximum depth of cut is limited by a depth stop 37 "designed as a shank collar, so that the necessary excavation can be made deep in the bone, at the correct angle, without the need for special skills on the part of the surgeon.
  • spacers 35 may be provided on the underside 10 of the base plate 1 be arranged (s. Fig. 3 ). These are designed in pairs and are mounted on mounting pins 36, which are inserted into the mounting holes 26, on the primary gauge 11 of the base plate 1 (s. Fig. 15a ). They are in different thicknesses (s. Fig. 15b ), so that fine adjustment can be made hereby.
  • Alternatives for the spacer are in Fig. 17 shown.
  • the position of the base frame 1 is defined by means of the alignment insert 3, this is by introducing the fixing pins 99 fixed in the openings 28 relative to the femur.
  • the alignment insert 3 and the rasp broach 92 can now be removed.
  • bone saw By means of a known per se and not described in detail bone saw can now be made using the posterior saw blade guide 19, a processing of the condyles at the dorsal end (s. Fig. 18c ).
  • the frontal saw insert 40 is inserted into the corresponding diagonal alternating guide 16, 16 ', depending on whether it is an implantation on the left side or the right side.
  • the orientation given by the double-arc-shaped recess 16, 16 ' is defined by the bipolar fixing by means of the oblong hole 42, in the end positions 43, 43' of which a fastening screw 13 is screwed into the central fastening 14. It is now along the V-shaped saw blade guides 41, 41 ', the frontal Kondylenseite processed by means of the known bone saw (s. Fig. 18a, b ).
  • the feeler gauge 39 which is inserted into the slot 27 on the base frame 1, the plane of rotation in one direction and by insertion into the kerf 40, 40 ', the plane of rotation in another direction oriented transversely thereto can be determined.
  • the point of rotation is determined by the intersection of the planes of rotation.
  • An alternative instrument is in Fig. 19 shown. It comprises a bridge girder as straightening gauge 39 'with tabs 39 "arranged on both sides.
  • the bridge girder 39' is inserted into receiving slots 17 on the base frame 1, and by the form-locking connection thus produced Connection, the orientation of the base frame 1 can be adjusted.
  • the length of the indexing tongues 39 "is dimensioned such that they indicate with their end the respectively resulting position of the pivot point Z (see FIG. Fig. 19b and c ). This allows a fast and easy to control alignment.
  • the first milling insert 4 is inserted into the base frame 1 and fixed by means of the central attachment 14, which is accessible through an opening 44, and the fastening screw 13.
  • the insert 4 has a large central opening 45 with an upwardly projecting guide sleeve 45 ', which form a receptacle for a broaching cutter 49.
  • This has in its upper region a collar 49 ', which cooperates with the upper edge of the guide sleeve 45' such that a depth stop for the Räumfräser 49 is formed.
  • a portion of the cavity required for implantation is created in the medullary cavity, and on the other hand, the wall left by the reamer is reduced in height in the front region (see FIG. Fig. 19 ).
  • the reduction of the height of the wall in the front area can alternatively be done by a bit 46, as in Fig. 20 shown.
  • the chisel 46 has a circular arc segment-like basic body with a also acting as a depth stop percussion head 46 'at the rear end.
  • a guide slot 47 complementary to the cross-sectional shape of the bit 46 is provided on the primary gauge 11.
  • the first milling insert 4 is exchanged for a second milling insert 5.
  • This has a double receptacle 51, which is CCTVförmig in cross section and two receiving positions 52, 53 forms for a volume cutter 59.
  • the two shots 52, 53 are not centered, but both with different offset to the side (Lateralversatz) arranged.
  • Each of the two receiving positions 52, 53 is associated with an upwardly projecting sleeve 52 ', 53'.
  • the volume milling cutter 59 likewise has a projecting collar 59 'in its upper region, which cooperates with the upper edge of the sleeve 52', 53 'associated with the respective receptacle 52, 53 and thus forms a depth stop for the volume milling cutter 59 (see FIG.
  • the second milling insert 5 just like the first milling insert 4, is uniquely positioned on the base frame 1 by means of an opening 54 aligned with the central fastening.
  • the second milling insert 5 is contained in two versions in the instrument. One version is designed for left-sided implantation and a second version, which is mirror-symmetrical, for right-sided implantation (see the second milling inserts 5, marked "L” and "R” in FIG Fig. 4 ).
  • the second milling insert 5 is replaced by a third milling insert 6, which is designed as a gate insert (s. Fig. 5 and 23a-c ).
  • This has two T-shaped oriented backdrop windows 60, 61 and two observation windows 62, 63.
  • the backdrop window 60 is formed as a slot and acts as a receptacle for the fastening screw 13, by means of which the slide insert is guided on the base frame 1.
  • the backdrop insert 6 can be moved back and forth to frontal and dorsal.
  • a slotted guide 65 is slidably inserted, which has a handle 64 with a receptacle 67 for a milling tool 68, 69.
  • the milling tools 68, 69 are a front and an end mill, by means of at different distances to Tip arranged stop collar 68 ', 69' are designed for different cutting depths (s. Fig. 5 and Fig. 23c ). They can be pushed through a central opening 67 in the handle 64 in the slotted guide 63.
  • a rectangular cavity cross-section can be milled with high precision. Thanks to the precise slotted guide, the cavity can be produced with a high degree of dimensional accuracy, thus preparing the box-like receiving space for the knee prosthesis in the femoral cavity.
  • FIG. 24 An alternative embodiment for the gate insert 6 is in Fig. 24 shown. It is a hinge insert 6 '. It has two articulated guide levers 60 ', 61'. With one end, they are rotatably supported by a pivot pin 62 'on a base plate of the insert 6', and at the other end a receptacle 67 'for the milling tools 68, 69 is formed. On the base plate of the gate insert 6 'is a U-shaped slide track 63' is formed, in which in the receptacle 67 'inserted milling tool 68, 69' is positively guided by the guide lever 60 ', 61'.
  • the pivot pin 62 ' is provided with a flattening 64', so that the guide lever 60 ', 61' can be placed on it or removed from it only in a predetermined mounting position.
  • the flattening 64 ' is aligned so that in the mounting position the receptacle 67' is off the slide track 63 '. This ensures that the assembly or disassembly can only be made when the milling tool 68, 69 is removed.
  • FIG. 25 An additional securing of the inserts 3, 4 and 5 in the base frame 1 is in Fig. 25 shown.
  • the securing opening 14 on the base frame is made in duplicate, namely a left-side 14 'and a right-side 14 ".
  • the mounting openings 34, 44 and 54 on the inserts 3, 4 and 5 are designed as grooves 32', 34" running to the edge and laterally offset from each other, depending on whether the respective use for left- or right-sided implantation is provided.
  • a safety lever 66 ' includes a knob 66 "at the end of a stub shaft Fig.
  • a securing bolt 14''' is preferably provided, which is inserted from the side into the base frame 1 and flush with a flattening 66 '''of the stub shaft such that the stub shaft and prevent the locking lever 66 'from rotating.
  • the safety lever 66 ' can only be adjusted again when the safety catch 14''' is removed.
  • the corresponding inserts are on their underside with an undercut bore 50 'in the case of an against lifting to be secured insert 5' (s. Fig. 26a ) and / or with the groove 34 ', 34 "and a widened end in the case of an insert 3' to be secured against displacement (see FIG. Fig. 26b ) Mistake. Shown in the two smaller figures in each case the open position (above in Fig. 26a or left in Fig. 26b ) and the closed position (lower In Fig. 26a or right in Fig. 26b ).
  • Fig. 7 to 10 Referenced After the preparation of the box-shaped receiving space in the femur, the processing of the slideways follows the condyles. It is especially on Fig. 7 to 10 Referenced. It is used by means of a setting tongs 76. It comprises two pincers halves 78, which has at its front ends two positively cooperating with the Bogenfräslehre 7 gripper 79. On the outside of each other pioneering alignment lugs 77 are formed. They are designed so that they are congruent to the shape of the guide slots 17 on the base frame 1.
  • the Bogenfräslehre 7 comprises a main body 70 whose basic shape corresponds approximately to a cuboid box (s. Fig. 7 ). On its lateral sides are formed vertically from top to bottom extending grooves 71. They serve for firmer and position-retaining anchoring in the cavity of the femur. On the upper side of the base body 70 an upwardly projecting circular arc segment 72 is integrally formed, which covers an angular range of about 100 to 120 degrees and is pulled down in the front region to about half the height of the base body 70. In the region near the edge, it has on one of its side surfaces a recessed guide track 74.
  • a double slot 77 extends to the top of the main body 70. Transversely to a receiving bore for a locking screw 79 is arranged. It acts as a pivot bearing 78 for a toggle lever 80, whose free end protrudes from the base body 70 and which is pivotable along the double slot 77 (s. Fig. 7 ).
  • the toggle lever 80 carries a pivot 81 whose cross-section is approximately rectangular with straight long sides and circular arc convex short sides is (s. Fig. 11a ). Between the arcuate convex short sides of the pivot 81 has a meridian largest width D and between the straight sides of a meridian smallest width d.
  • the guide piece 8 is generally T-shaped with a transverse segment 89 and a longitudinal segment 88 (see FIG. Fig. 8 ).
  • a stepped bore 87 with a circumferential shoulder are arranged in the outer regions. They are oriented with their axis 87 'so that they form an angle ⁇ of 75 to 85 degrees, preferably 80 degrees to the transverse segment 89. This diverge the axes 87 '.
  • the stepped bore 87 forms a guide for a Kondylenfräser 85 which is inserted through a lateral opening 82 in the stepped bore 87.
  • the condyle milling cutter 85 comprises a milling head and a shank, on which a cylindrical thickening 86 spaced from the milling head is formed. By resting on the circumferential shoulder of the stepped bore 87, it limits the depth of cut.
  • the longitudinal segment 88 of the guide piece 8 is angled; it forms an angle of about 15 to 25 degrees, preferably 20 degrees to the plane spanned by the axes 87 '.
  • the follower 84 is arranged laterally, which guides the guide piece 8 along the guide track 74.
  • the longitudinal segment 88 is forked and provided with a transverse bore, which acts as a rotary bearing sleeve 83. It is open over a narrowing 83 'to the free end.
  • the width of the constriction 83 ' is dimensioned so that it is larger than the meridian smallest width 82 and smaller than the meridian largest width 82'.
  • the pivot pin 81 is oriented on the toggle lever 80 such that coupling or removal of the guide piece 8 can only take place in an extended position when the guide piece 8 forms a line with the toggle lever 80 (see FIG. 11a ).
  • the guide piece 8 with its follower 84 is inserted into the guide track in the region of the extension 74 ', wherein the guide piece 8 is in an angled position relative to the toggle lever 80 (ie no longer stretched).
  • the pivot 81 is prevented from passing through the restriction 83 '.
  • the inserted into the guideway 74 guide 8 is thus securely locked to the toggle 80 (s. Fig. 11b ).
  • Fig. 12 The kinematics achieved for the guidance of the Kondylenfräsers 85 is in Fig. 12 shown as a multiphase diagram. Down in the middle of the picture, the pivot bearing 78 is shown. It forms a fixed pivot point for the cam guide consisting of guide track 74, guide 8, and toggle lever 80 is. The guide piece 8 is guided over its follower 84 over the entire pivoting range along the guide track 74.
  • the guideway 74 has a (in the figure from left to right) increasing curvature, whereby the radial distance enlarged between pivot bearing 79 and follower 84.
  • FIG. 13a, b An alternative embodiment of the guide piece for another condyle milling is in Fig. 13a, b shown.
  • FIG. 13a illustrated variant of the horizontal cutter 85 'from the side in the guide piece 8' and stored there on one side.
  • the motion kinematics corresponds to those in Fig. 12 shown.
  • the in Fig. 13b The knee lever and the guide piece 8 "are arranged on the outside, and the horizontal cutter 85" is inserted through the guide piece 8 " Retrofit 8 "for machining the other side.
  • the instrument set further includes a set of teeth for the creation and preparation of a prosthesis receptacle in the femur.
  • the Ahlensatz (s. Fig. 6 ) includes an access eyelet 90 which serves to open the medullary cavity of the femur.
  • the medullary cavity is successively increased.
  • the special rasp broach 92 is provided with the stop plate 97, which have already been described above.
  • a pinhole drill 98 is provided with a stop which is inserted into the drill guides 18 for forming receptacles for anchoring pins (not shown) on a condyle part of the knee joint endoprosthesis.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Surgical Instruments (AREA)
  • Prostheses (AREA)
EP11163566A 2011-04-21 2011-04-21 Instrumentarium zum Einsetzen einer Gelenkprothese, insbesondere Knieprothese Withdrawn EP2514372A1 (de)

Priority Applications (21)

Application Number Priority Date Filing Date Title
EP11163566A EP2514372A1 (de) 2011-04-21 2011-04-21 Instrumentarium zum Einsetzen einer Gelenkprothese, insbesondere Knieprothese
JP2014505627A JP6047554B2 (ja) 2011-04-21 2012-04-19 人工関節、特に人工膝関節の挿入用装具
PL12715109T PL2699171T3 (pl) 2011-04-21 2012-04-19 Oprzyrządowanie do wstawiania protezy stawu, zwłaszcza protezy kolana
ES12715109.0T ES2551391T3 (es) 2011-04-21 2012-04-19 Instrumental para la inserción de una prótesis articulada, en particular prótesis de rodilla
PCT/EP2012/057163 WO2012143444A1 (de) 2011-04-21 2012-04-19 Instrumentarium zum einsetzen einer gelenkprothese, insbesondere knieprothese
US14/113,092 US9855061B2 (en) 2011-04-21 2012-04-19 Equipment for inserting a joint prosthesis, in particular a knee prosthesis
KR1020137030764A KR101965005B1 (ko) 2011-04-21 2012-04-19 관절 보철물, 특히, 무릎 보철물을 삽입하기 위한 장비
HUE12715109A HUE026159T2 (en) 2011-04-21 2012-04-19 Tool for joint prosthesis, especially for implantation of knee prosthesis
MX2013012169A MX343887B (es) 2011-04-21 2012-04-19 Instrumental para la inserción de una prótesis articulada, en particular prótesis de rodilla.
AU2012244702A AU2012244702B2 (en) 2011-04-21 2012-04-19 Equipment for inserting a joint prosthesis, in particular a knee prosthesis
UAA201313466A UA113624C2 (xx) 2011-04-21 2012-04-19 Обладнання для встановлення протеза суглоба, зокрема протеза колінного суглоба
BR112013026871-9A BR112013026871B1 (pt) 2011-04-21 2012-04-19 equipamento para inserção de uma prótese articulada, especialmente um componente femural de uma prótese para joelho
RU2013150699A RU2607957C2 (ru) 2011-04-21 2012-04-19 Оборудование для установки протеза сустава, в частности протеза коленного сустава
PT127151090T PT2699171E (pt) 2011-04-21 2012-04-19 Instrumentária para a inserção de uma prótese articular, particularmente de uma prótese de joelho
CA2833294A CA2833294C (en) 2011-04-21 2012-04-19 Equipment for inserting a joint prosthesis, in particular a knee prosthesis
CN201280030655.2A CN103781427B (zh) 2011-04-21 2012-04-19 用于装上关节假体特别是膝盖假体的设备
EP12715109.0A EP2699171B1 (de) 2011-04-21 2012-04-19 Instrumentarium zum einsetzen einer gelenkprothese, insbesondere knieprothese
IL228940A IL228940A (en) 2011-04-21 2013-10-17 Equipment for inserting a prosthetic joint, in particular a knee prosthesis
CO13271971A CO6852035A2 (es) 2011-04-21 2013-11-19 Instrumental para la inserción de una prótesis articulada, en particular prótesis de rodilla
ZA2013/08715A ZA201308715B (en) 2011-04-21 2013-11-20 Equipment for inserting a joint prosthesis, in particular a knee prosthesis
HK14108531.3A HK1194951A1 (zh) 2011-04-21 2014-08-21 用於裝上關節假體特別是膝蓋假體的設備

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11163566A EP2514372A1 (de) 2011-04-21 2011-04-21 Instrumentarium zum Einsetzen einer Gelenkprothese, insbesondere Knieprothese

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EP2514372A1 true EP2514372A1 (de) 2012-10-24

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EP11163566A Withdrawn EP2514372A1 (de) 2011-04-21 2011-04-21 Instrumentarium zum Einsetzen einer Gelenkprothese, insbesondere Knieprothese
EP12715109.0A Active EP2699171B1 (de) 2011-04-21 2012-04-19 Instrumentarium zum einsetzen einer gelenkprothese, insbesondere knieprothese

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EP12715109.0A Active EP2699171B1 (de) 2011-04-21 2012-04-19 Instrumentarium zum einsetzen einer gelenkprothese, insbesondere knieprothese

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US (1) US9855061B2 (es)
EP (2) EP2514372A1 (es)
JP (1) JP6047554B2 (es)
KR (1) KR101965005B1 (es)
CN (1) CN103781427B (es)
AU (1) AU2012244702B2 (es)
BR (1) BR112013026871B1 (es)
CA (1) CA2833294C (es)
CO (1) CO6852035A2 (es)
ES (1) ES2551391T3 (es)
HK (1) HK1194951A1 (es)
HU (1) HUE026159T2 (es)
IL (1) IL228940A (es)
MX (1) MX343887B (es)
PL (1) PL2699171T3 (es)
PT (1) PT2699171E (es)
RU (1) RU2607957C2 (es)
UA (1) UA113624C2 (es)
WO (1) WO2012143444A1 (es)
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CO6852035A2 (es) 2014-01-30
HUE026159T2 (en) 2016-05-30
CN103781427A (zh) 2014-05-07
RU2607957C2 (ru) 2017-01-11
HK1194951A1 (zh) 2014-10-31
PT2699171E (pt) 2015-11-12
JP2014516629A (ja) 2014-07-17
KR101965005B1 (ko) 2019-04-02
IL228940A (en) 2016-10-31
RU2013150699A (ru) 2015-05-27
JP6047554B2 (ja) 2016-12-21
CA2833294A1 (en) 2012-10-26
ZA201308715B (en) 2014-07-30
CA2833294C (en) 2019-06-11
ES2551391T3 (es) 2015-11-18
CN103781427B (zh) 2016-11-23
AU2012244702B2 (en) 2016-10-20
KR20140047608A (ko) 2014-04-22
US20140046331A1 (en) 2014-02-13
EP2699171B1 (de) 2015-08-12
IL228940A0 (en) 2013-12-31
UA113624C2 (xx) 2017-02-27
BR112013026871B1 (pt) 2020-10-27
US9855061B2 (en) 2018-01-02
MX343887B (es) 2016-11-28
WO2012143444A1 (de) 2012-10-26
PL2699171T3 (pl) 2015-12-31
AU2012244702A1 (en) 2013-12-05
EP2699171A1 (de) 2014-02-26
MX2013012169A (es) 2014-08-18

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