EP2490649B1 - Machine et procédé permettant de remplir et de sceller des capsules composées en particulier de gélatine dure - Google Patents

Machine et procédé permettant de remplir et de sceller des capsules composées en particulier de gélatine dure Download PDF

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Publication number
EP2490649B1
EP2490649B1 EP10759882.3A EP10759882A EP2490649B1 EP 2490649 B1 EP2490649 B1 EP 2490649B1 EP 10759882 A EP10759882 A EP 10759882A EP 2490649 B1 EP2490649 B1 EP 2490649B1
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EP
European Patent Office
Prior art keywords
capsules
capsule
conveying wheel
conveying
filling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP10759882.3A
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German (de)
English (en)
Other versions
EP2490649A1 (fr
Inventor
Werner Runft
Ralf Schmied
Timm Sattler
Martin Vogt
Martin Wunderlich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Robert Bosch GmbH
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Robert Bosch GmbH
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Publication of EP2490649A1 publication Critical patent/EP2490649A1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/074—Filling capsules; Related operations

Definitions

  • the invention relates to a machine and to a method for filling and closing capsules, in particular consisting of hard gelatin, according to the preambles of the independent claims.
  • Such a machine is from the DE 10 2004 048 007 A1 known.
  • processing stations are arranged on the circulation path of a cyclically rotating in one direction conveyor wheel at uniform angular intervals, which are approached by the respective one particular angle step exporting conveyor wheel gradually.
  • a device is required within the processing station in order to carry out a specific processing step.
  • the conveying wheel moves only in one direction, it is necessary to arrange the processing stations according to the timing of filling and closing the capsules.
  • a disadvantage is that these processing stations have a certain space requirement, so that at successive processing stations, each with relatively high space requirement, the conveyor wheel as a whole builds relatively large or a complex design or lower performance at the processing stations must be taken into account (if the latter is smaller have to be canceled).
  • the machine concept with a cyclically rotating in one direction conveyor wheel in terms of its functionality or flexibility in terms of changes to the processing stations relative inflexible. This is particularly disadvantageous in research, where the performance of the machine plays a minor role.
  • a similar device is also from the DE 10 2006 035 280 A1 known.
  • the present invention seeks to further develop a machine and a method for filling and closing capsules, in particular made of hard gelatin such that an almost arbitrary arrangement of processing stations on the circulation path of the feed wheel can be made possible.
  • This object is achieved in a machine for filling and closing of existing in particular of hard gelatin capsules having the features of claim 1.
  • the invention is based on the idea, by a drive in which the conveying path or the angular step (at a cyclic operation) and the direction of rotation of the feed wheel is variably adjustable to allow the individual processing stations by the variable drive ultimately independent of their Arrangement can be approached on the feed wheel. This allows, for example, a space-optimized arrangement of processing stations or a high degree of flexibility with regard to the individual processing or process steps. Also, thus continuous movements of the feed wheel can be achieved.
  • the drive of the feed wheel additionally takes place continuously and that at least one station is arranged on the circulation path of the feed wheel, which requires a continuous movement of the receiving segment.
  • the capsules must be guided past a line scan camera or the like, wherein, for example, the state of the capsules with respect to damage or the like is detected when passing the capsules on the line scan camera. This is relatively easy with a variably designed drive, while otherwise, for example, consuming designed testing equipment would be required.
  • At least one processing station a plurality of similar processing devices or processing devices are arranged with the same type of process steps, which are all controlled by a capsule. So it is conceivable, for example, that capsules from a receiving segment gradually get into the area of individual stuffing dies in a processing station, without requiring a change of the processing station is required. Thereby, e.g. the costs for the drives are reduced at the processing station, since otherwise several processing stations, each with separate drives would be required.
  • the receiving segments for the capsules are arranged exchangeably on the delivery wheel.
  • the receiving segments for the capsules are arranged exchangeably on the delivery wheel.
  • a variety of recording segments for a variety of capsules with possibly a different number of receiving holes can be used, as is usually required in the processing of different capsules, for example in research.
  • the machine according to the invention can thus be flexibly adapted to a wide variety of machining processes and capsule formats in a simple manner.
  • the invention also includes a calibration method for a testing device operating in particular with X-ray radiation, which is arranged on the circulation path of the machine.
  • a testing device operating in particular with X-ray radiation
  • various stations and the testing device bypassing other stations, specifically approached, so that only the necessary for calibration conveyor cycles are realized.
  • a machine 100 for filling and capping capsules c especially made of hard gelatin, is shown.
  • the capsules c can also be made of another suitable material.
  • the capsules c each have a capsule lower part a and a cap b.
  • the far known capsules c are filled by means of the machine 100 in particular by means of a pharmaceutical which, for example, in the form of powder, pellets, a liquid, tablets or the like. is present.
  • the machine has a feed wheel 20, on whose outer circumference at regular angular intervals, for example, twelve receiving segments 21 are arranged interchangeably. Each of the receiving segments 21 has a certain number of in the exemplary embodiment five juxtaposed receiving bores 22 for each capsule c.
  • the feed wheel 20 is rotatably mounted in a vertically arranged axis of rotation 24 and, for this purpose, according to the invention has a drive designed as a servomotor 25, which can be actuated by a control device 26 of the machine 100.
  • the feed wheel 20 can be moved in arbitrarily small angular steps corresponding to the double arrow 27 both clockwise and counterclockwise, wherein both cyclic movements, as well as continuous movements by means of the servo motor 25 can be realized.
  • twelve stations 1 to 12 are arranged by way of example, on which processing devices can be provided, wherein, depending on the application, not all stations 1 to 12 must be provided with a processing device.
  • the in the Fig. 1 illustrated embodiment of the invention is provided for example at the station 1 to supply the capsules c, to orient and separate.
  • the station 2 recording segments (not shown), which alone carry the caps b, of the in the FIG. 1 shown recording segments 21 separately.
  • the receiving segments 21 are checked for the presence of capsule subparts a or caps b on the receiving segments 21 (or on the receiving segments (not shown) for the caps b).
  • the contents can be dispensed in the form of pellets or tablets at the station 3 in the capsule parts a.
  • no processing facilities are provided at the stations 4 and 6 .
  • 5 powders or pellets and at the station 7 pellets and tablets are each discharged into the capsule parts a at the station.
  • a capsule ejection device is provided, which ejects incorrectly filled capsules c by means of compressed air from the machine 100.
  • it is provided to bring the receiving segments 21 for the capsule lower parts a and the receiving segments (not shown) for the caps b into coincidence again in order to close the capsules c in the region of the subsequent station 10.
  • the station 11 it is optionally provided to provide an additional testing device having an additional ejection station for defective capsules c.
  • the station 12 is provided as a cleaning station for cleaning the receiving segments 21.
  • the servo motor 25 By means of the servo motor 25 is now a variable operation of the machine 100 possible, which is based on the Fig. 2 to 4 is explained in more detail. Here, the simplicity and the sake of clarity due to various stations or components of the machine 100 are no longer shown. Furthermore, in contrast to the receiving segments 21, the receiving segments 31 are provided with only two receiving bores 32, 33.
  • a station which has two processing devices 35 and 36.
  • the processing devices 35 and 36 are in particular similar processing devices, for example to dosing devices.
  • a first process step Y is carried out by the first processing device 35
  • a second process step X is carried out by the second processing device 36.
  • the Fig. 2 recognizes, in a first step, the two receiving holes 32 and 33 aligned with the corresponding processing means 35 and 36, so that the capsule c located in the receiving bore 32 is subjected to a process step Y, while the capsule located in the receiving bore 33 c through the second Processing device 36 passes through a process step X.
  • the feed wheel 20 is rotated counterclockwise by the distance between the two receiving bores 32 and 33 so that now the capsule c located in the receiving bore 33 is subjected to a process step Y by means of the first processing device 35, while the capsule c located in the receiving bore 32 does not process it experiences.
  • the conveyor wheel 20 is further rotated counterclockwise so far that the receiving bore 32 with the capsule c in registration with the second processing device 36 is located. In this processing step, the capsule c located in the receiving bore 32 is now subjected to a process step X.
  • a modified machine 100a is shown.
  • the machine 100a has twelve processing stations 1 to 12, of which, however, for the sake of clarity, only a few processing stations 1 to 12 shown in detail and are explained in more detail below.
  • a weighing device 40 is arranged in the area next to the processing station 3, which serves to separate the caps b from the capsule bases a. By means of the weighing device 40, in particular random samples, individual capsules c can be removed from the receiving bores 22 of the receiving segments 21 and weighed.
  • a filling device 41 is arranged by way of example, by means of which a certain amount of filling material is metered into the capsule parts a. Furthermore, an error capsule station 42 is arranged at the processing station 8, by means of which capsules c previously identified as defective or incorrectly filled are eliminated.
  • a testing device 45 is arranged at the processing station 11 .
  • the test device 45 operates in the illustrated embodiment with an X-ray source 46 and serves in particular, but not restrictively, to check the filling weight of filled capsules c.
  • an X-ray source 46 As an alternative to an X-ray source 46, however, another radiation source can also be provided. With regard to the exact training or characteristics of such a test device 45 is on the DE 10 2009 045 809 A1 the applicant, to which reference is made.
  • the machine is 100a suitable by their trained as a servomotor 25 drive in a special way.
  • calibrating the testing device 45 an empty capsule c is first inserted at the processing station 1 into a receiving bore 22 of a receiving segment 21.
  • the servomotor 25 controls the processing station 3 with the capsule c. This is done by a rotation of the feed wheel 20 in a clockwise direction.
  • the empty capsule c is removed from the receiving bore 22 of its receiving segment 21 and weighed by means of the weighing device 40.
  • a net weight of the capsule c is determined, which is supplied to the control device 26 as an input variable.
  • the empty capsule c is again inserted into the receiving bore 22 and fed by means of the feed wheel 20, in turn clockwise, the filling device 41. There, the empty capsule c is filled with a desired filling. Subsequently, the filled capsule c is fed back into the region of the processing station 3 in the counterclockwise direction, taken there and fed to the additional weighing device 40. This determines a gross weight of the filled capsule c, and passes the corresponding signal to the controller 26 as an input. The control device 26 can thus determine the filling quantity from the two weight weights by subtracting from the gross weight the net weight of the capsule c.
  • the capsule c brought back into its receiving bore 22 is again transported by means of the conveying wheel 20 in the counterclockwise direction, bypassing the error capsule station 42, directly into the area of the testing device 45. There, the filling weight of the capsule c is determined by means of the test device 45.
  • Such a calibration process can, as described, take place either by means of a single capsule c. However, it can also be provided that in each case several capsules c are weighed and tested accordingly. It is essential to the invention that the machine 100a for the calibration of the test device 45 conveys capsules c in the clockwise direction and counterclockwise, whereby only the processing stations 1 to 12 which are required for the calibration are approached. Thus, both different directions of movement, as well as different lengths of conveyor lines for approaching temporally successive processing stations 1 to 12 are realized.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Basic Packing Technique (AREA)

Claims (10)

  1. Machine (100 ; 100a) pour remplir et sceller des capsules (c) constituées notamment de gélatine dure, comprenant une roue de transport (20) qui est montée à rotation dans un axe vertical (24) et qui est au moins déplacée par impulsions, comprenant des segments de réception (21 ; 31) disposés sur la périphérie extérieure de la roue de transport (20), pour un nombre déterminé respectif de capsules (c) et comprenant des postes de traitement (1 à 12) pour les capsules (c), disposés sur la trajectoire périphérique de la roue de transport (20),
    caractérisée en ce que
    la roue de transport (20) présente un entraînement (25) réalisé de préférence sous forme de servomoteur (25), au moyen duquel au moins la trajectoire de transport et la direction de transport de la roue de transport (20) peuvent être ajustées de manière variable pendant une impulsion de transport.
  2. Machine selon la revendication 1,
    caractérisée en ce que
    l'entraînement de la roue de transport (20) peut en outre s'effectuer en continu, et en ce qu'au moins un poste est disposé sur la trajectoire périphérique de la roue de transport (20), lequel exige un mouvement continu du segment de réception (21 ; 31).
  3. Machine selon la revendication 1 ou 2,
    caractérisée en ce
    qu'au niveau d'au moins un poste de traitement (3) sont disposés plusieurs dispositifs de traitement (35, 36) qui sont tous commandés par une capsule (c).
  4. Machine selon la revendication 3,
    caractérisée en ce que
    les dispositifs de traitement (35, 36) concernent un processus de traitement de même type.
  5. Machine selon l'une quelconque des revendications 1 à 4,
    caractérisée en ce que
    les segments de réception (21 ; 31) pour les capsules (c) sont disposés de manière interchangeable sur la roue de transport (20).
  6. Machine selon l'une quelconque des revendications 1 à 5,
    caractérisée en ce que
    les segments de réception (21 ; 31) sont disposés à intervalles angulaires uniformes sur la roue de transport (20).
  7. Machine selon l'une quelconque des revendications 1 à 6,
    caractérisée en ce que
    l'un des postes de traitement est réalisé sous forme de dispositif de contrôle (45) fonctionnant avec un rayonnement, notamment un rayonnement X, qui sert au moins à détecter le poids de remplissage des capsules (c).
  8. Machine selon la revendication 7,
    caractérisée en ce que
    dans la région des postes de traitement (1 à 12) est disposé un dispositif de pesée (40).
  9. Procédé pour faire fonctionner une machine (100 ; 100a) pour remplir et sceller des capsules (c) constituées notamment de gélatine dure, dans lequel une roue de transport (20), qui est montée à rotation dans un axe vertical (24), est déplacée au moyen d'un entraînement (25) et est en l'occurrence acheminée à des postes de traitement (1 à 12) pour les capsules (c) disposés sur la trajectoire périphérique de la roue de transport (20), avec des segments de réception (21 ; 31) pour un nombre déterminé respectif de capsules (c) disposés sur la périphérie extérieure de la roue de transport (20),
    caractérisé en ce que
    l'entraînement (25) de la roue de transport (20) déplace la roue de transport (20) de telle sorte qu'au moins la trajectoire de transport ou la direction de transport de la roue de transport (20) soit modifiée lors d'une impulsion de transport au démarrage de postes de traitement (1 à 12) les uns après les autres dans le temps.
  10. Procédé selon la revendication 9,
    caractérisé en ce que
    pour le calibrage d'un dispositif de contrôle (45) fonctionnant avec un rayonnement, en particulier avec un rayonnement X, au moins une capsule vide (c) est acheminée dans une première étape à un dispositif de pesée (40) pour déterminer un poids net des capsules (c), en ce qu'ensuite, dans une deuxième étape, l'au moins une capsule vide (c) est acheminée à au moins un dispositif de remplissage (41), en ce qu'ensuite, dans une troisième étape, la capsule remplie (c) est à nouveau acheminée au dispositif de pesée (40) pour déterminer un poids brut de la capsule (c), puis le dispositif de commande (26) de la machine (100a) détermine le poids de remplissage de la capsule (c), et en ce qu'ensuite, dans une quatrième étape, les capsules remplies (c) sont acheminées au dispositif de contrôle (45) fonctionnant avec un rayonnement, notamment avec un rayonnement X, dans lequel le poids de remplissage des capsules (c) est déterminé, un calibrage du dispositif de contrôle (45) se produisant à partir de la différence des poids de remplissage déterminés par le dispositif de pesée (40) et le dispositif de contrôle (45).
EP10759882.3A 2009-10-22 2010-09-28 Machine et procédé permettant de remplir et de sceller des capsules composées en particulier de gélatine dure Active EP2490649B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102009045917 2009-10-22
DE102010040505A DE102010040505A1 (de) 2009-10-22 2010-09-09 Maschine und Verfahren zum Füllen und Verschließen von insbesondere aus Hartgelatine bestehenden Kapseln
PCT/EP2010/064292 WO2011047935A1 (fr) 2009-10-22 2010-09-28 Machine et procédé permettant de remplir et de sceller des capsules composées en particulier de gélatine dure

Publications (2)

Publication Number Publication Date
EP2490649A1 EP2490649A1 (fr) 2012-08-29
EP2490649B1 true EP2490649B1 (fr) 2013-12-18

Family

ID=43796955

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10759882.3A Active EP2490649B1 (fr) 2009-10-22 2010-09-28 Machine et procédé permettant de remplir et de sceller des capsules composées en particulier de gélatine dure

Country Status (5)

Country Link
EP (1) EP2490649B1 (fr)
CN (1) CN102573757B (fr)
DE (1) DE102010040505A1 (fr)
IN (1) IN2012DN01739A (fr)
WO (1) WO2011047935A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102013113446B4 (de) 2013-12-04 2017-04-13 Fette Engineering GmbH Vorrichtung und Verfahren zum Befüllen von Kapseln
DE102013114693A1 (de) 2013-12-20 2015-06-25 Fette Engineering GmbH Stopfstempelstation und Verfahren zum Füllen von Kapseln in einer Stopfstempelstation
DE102015103245B3 (de) * 2015-03-05 2016-06-02 Fette Engineering GmbH Verfahren zum Betreiben einer Kapselfüllmaschine
DE102015106369B4 (de) * 2015-04-24 2020-02-13 Fette Engineering GmbH Kapselfüllmaschine
DE102016218085A1 (de) 2016-09-21 2018-03-22 Robert Bosch Gmbh Wirbelschichtanlage
DE102018200068A1 (de) 2018-01-04 2019-07-04 Robert Bosch Gmbh Einrichtung zur Ermittlung des Gewichts einer in einem Kapselhalter eines schrittweise gedrehten Förderrads angeordneten Kapsel
CN112190480A (zh) * 2020-10-23 2021-01-08 星德科包装技术(杭州)有限公司 胶囊填充机

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2274492Y (zh) * 1996-12-17 1998-02-18 柯拔希 自动胶囊充填机
IT1304779B1 (it) * 1998-12-03 2001-03-29 Ima Spa Dosatrice a disco ed a pestelli, a funzionamento intermittente,monogiostra, particolarmente adatta per il confezionamento di dosi
IT1316684B1 (it) * 1999-03-13 2003-04-24 Bosch Gmbh Robert Supporto delle parti di capsule in una macchina di caricamento e dichiusura per capsule in due parti
ITBO20040310A1 (it) * 2004-05-18 2004-08-18 Ima Spa Macchina opercolatrice e relativo metodo per la produzione di capsule in gelatina dura.
DE102004048007A1 (de) 2004-10-01 2006-04-06 Robert Bosch Gmbh Maschine zum Füllen und Verschließen von zweiteiligen Kapseln
US20070028560A1 (en) * 2005-08-08 2007-02-08 Darrell Gauthier Machine for filling and closing two-piece capsules
DE102006035280A1 (de) * 2006-07-31 2008-02-07 Robert Bosch Gmbh Vorrichtung und Verfahren zum Ausstoßen zumindest einer Kapsel
CN100556394C (zh) * 2007-03-12 2009-11-04 浙江富昌机械有限公司 胶囊充填机的充填回转密封机构
CN101305965B (zh) * 2008-02-03 2011-08-10 瑞安市飞云机械厂 一种全自动胶囊充填机
KR101384358B1 (ko) * 2008-03-18 2014-04-21 삼성전자주식회사 반도체 모듈 핸들링 시스템

Also Published As

Publication number Publication date
IN2012DN01739A (fr) 2015-06-05
CN102573757B (zh) 2014-10-29
WO2011047935A1 (fr) 2011-04-28
CN102573757A (zh) 2012-07-11
DE102010040505A1 (de) 2011-04-28
EP2490649A1 (fr) 2012-08-29

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