EP2490530A4 - Verbindungen und verfahren zur behandlung von bakteriellen infektionen - Google Patents

Verbindungen und verfahren zur behandlung von bakteriellen infektionen

Info

Publication number
EP2490530A4
EP2490530A4 EP10825785.8A EP10825785A EP2490530A4 EP 2490530 A4 EP2490530 A4 EP 2490530A4 EP 10825785 A EP10825785 A EP 10825785A EP 2490530 A4 EP2490530 A4 EP 2490530A4
Authority
EP
European Patent Office
Prior art keywords
compounds
methods
bacterial infections
treating bacterial
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10825785.8A
Other languages
English (en)
French (fr)
Other versions
EP2490530A1 (de
Inventor
James W Janetka
Zhenfu Han
Scott Hultgren
Jerry Pinkner
Corinne Cusumano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Washington University in St Louis WUSTL
Original Assignee
University of Washington
Washington University in St Louis WUSTL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Washington University in St Louis WUSTL filed Critical University of Washington
Priority to EP18214928.6A priority Critical patent/EP3492483A1/de
Publication of EP2490530A1 publication Critical patent/EP2490530A1/de
Publication of EP2490530A4 publication Critical patent/EP2490530A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/075—Benzo[b]pyran-2-ones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP10825785.8A 2009-10-22 2010-10-22 Verbindungen und verfahren zur behandlung von bakteriellen infektionen Withdrawn EP2490530A4 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP18214928.6A EP3492483A1 (de) 2009-10-22 2010-10-22 Verbindungen und verfahren zur behandlung von bakteriellen infektionen

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25413509P 2009-10-22 2009-10-22
US32173810P 2010-04-07 2010-04-07
US38453510P 2010-09-20 2010-09-20
PCT/US2010/053848 WO2011050323A1 (en) 2009-10-22 2010-10-22 Compounds and methods for treating bacterial infections

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP18214928.6A Division EP3492483A1 (de) 2009-10-22 2010-10-22 Verbindungen und verfahren zur behandlung von bakteriellen infektionen

Publications (2)

Publication Number Publication Date
EP2490530A1 EP2490530A1 (de) 2012-08-29
EP2490530A4 true EP2490530A4 (de) 2014-01-22

Family

ID=43900714

Family Applications (2)

Application Number Title Priority Date Filing Date
EP10825785.8A Withdrawn EP2490530A4 (de) 2009-10-22 2010-10-22 Verbindungen und verfahren zur behandlung von bakteriellen infektionen
EP18214928.6A Withdrawn EP3492483A1 (de) 2009-10-22 2010-10-22 Verbindungen und verfahren zur behandlung von bakteriellen infektionen

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP18214928.6A Withdrawn EP3492483A1 (de) 2009-10-22 2010-10-22 Verbindungen und verfahren zur behandlung von bakteriellen infektionen

Country Status (2)

Country Link
EP (2) EP2490530A4 (de)
WO (1) WO2011050323A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2732806A1 (en) 2008-08-04 2010-02-11 John Wityak Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
CA2784087A1 (en) * 2009-12-14 2011-06-23 University Of Basel Mannose derivatives as antagonists of bacterial adhesion
KR20120131161A (ko) 2010-01-25 2012-12-04 씨에이치디아이 파운데이션, 인코포레이티드 특정 키뉴레닌-3-모노옥시게나제 억제제, 그의 제약 조성물 및 사용 방법
ES2732311T3 (es) 2011-02-07 2019-11-21 Univ Washington Compuestos de manósidos y procedimientos de uso de los mismos
WO2012164074A1 (en) * 2011-06-03 2012-12-06 University Of Basel Mannose phosphate derivatives as antagonists of bacterial adhesion
WO2013033068A1 (en) 2011-08-30 2013-03-07 Stephen Martin Courtney Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
BR112014004741B1 (pt) 2011-08-30 2021-10-13 Chdi Foundation, Inc Entidade química, seu uso e composição farmacêutica compreendendo a mesma
PL2935302T3 (pl) * 2012-12-18 2018-12-31 Vertex Pharmaceuticals Incorporated Pochodne mannozy do leczenia infekcji bakteryjnych
CA2905019C (en) 2013-03-12 2021-07-06 Vertex Pharmaceuticals Incorporated Mannose derivatives for treating bacterial infections
CN105682665A (zh) 2013-05-30 2016-06-15 华盛顿大学 用于治疗细菌性感染的化合物和方法
MX2017000779A (es) 2014-07-17 2017-07-27 Chdi Foundation Inc Metodos y composiciones para el tratamiento de trastornos relacionados con el vih.
CN104119407B (zh) * 2014-07-31 2017-07-28 济南尚博生物科技有限公司 一种甲基‑2,3,4‑三氧‑苄基‑β‑D‑吡喃核糖苷的合成方法
CN105622685B (zh) * 2015-12-31 2019-08-23 杭州科本药业有限公司 一种糖基苯并咪唑化合物及其制备方法和应用
JP2019509315A (ja) 2016-03-23 2019-04-04 フィンブリオン セラピューティックス， インコーポレイテッドＦｉｍｂｒｉｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 疾患の処置に有用なＦｉｍＨのマンノース由来アンタゴニスト
AU2018351471A1 (en) 2017-10-16 2020-05-07 Enterome New tools for assessing FimH blockers therapeutic efficiency
IL277071B1 (en) 2018-03-08 2024-03-01 Incyte Corp Aminopyrizine diol compounds as PI3K–y inhibitors
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS
LT3820856T (lt) 2018-07-10 2022-11-10 Glaxosmithkline Intellectual Property Development Limited C-manozido junginiai, naudingi šlapimo takų infekcijoms gydyti
TW202039481A (zh) 2018-12-21 2020-11-01 美商西建公司 Ripk2之噻吩并吡啶抑制劑
WO2020225273A1 (en) * 2019-05-07 2020-11-12 Glaxosmithkline Intellectual Property Development Limited Novel compounds
CN111423478A (zh) * 2020-04-16 2020-07-17 山东大学 一种含有炔丙基的木糖及其合成方法
CN115368332B (zh) * 2022-08-22 2024-03-12 三峡大学 6-芳/烷硫基-2h-吡喃-3-酮类化合物的合成方法及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0383092A2 (de) * 1989-02-13 1990-08-22 Bayer Corporation Chromogenische Merocyanin-Enzym-Substrate
US20070167378A1 (en) * 2003-10-08 2007-07-19 Saraiva Maria Joao M Compounds useful for the treatment of diseases associated with the formation of amyloid fibrils

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6420127B1 (en) * 1994-11-18 2002-07-16 Washington University Compounds and pharmaceutical compositions for the treatment and prophylaxis of bacterial infections
EP1755619A2 (de) * 2004-03-23 2007-02-28 VIB vzw Anti-adhäsive verbindungen zur prävention und behandlung von bakterieninfektionen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0383092A2 (de) * 1989-02-13 1990-08-22 Bayer Corporation Chromogenische Merocyanin-Enzym-Substrate
US20070167378A1 (en) * 2003-10-08 2007-07-19 Saraiva Maria Joao M Compounds useful for the treatment of diseases associated with the formation of amyloid fibrils

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
A. STOLL ET AL: "Das Furocumarin und die beta-D-Glucosido-furocumarinsäure aus den Samen von Coronilla-Arten. 23. Mitteilung über Herzglykoside", HELVETICA CHIMICA ACTA, vol. 33, no. 6, 1 January 1950 (1950-01-01), pages 1637 - 1647, XP055094084, ISSN: 0018-019X, DOI: 10.1002/hlca.19500330631 *
DENNIS A. SHUMAN ET AL: "Synthesis and biological activity of certain 8-mercaptopurine and 6-mercaptopyrimidine S-nucleosides", JOURNAL OF MEDICINAL CHEMISTRY, vol. 12, no. 4, 1 July 1969 (1969-07-01), pages 653 - 657, XP055094096, ISSN: 0022-2623, DOI: 10.1021/jm00304a021 *
FAROUK M E ABDEL-MEGEID ET AL: "PREPARATION AND SOME REACTIONS OF D-GLUCOSYL DERIVATIVES OF 2-THIOXO-1,3,4-OXADIAZOLES AND 2-THIOXO- 1,3,4-THIADIAZOLES AND THEIR 2-OXO ANALOGUES*", CARBOHYDRATE RESEARCH, vol. 59, 1 January 1977 (1977-01-01), pages 95 - 102, XP055094075 *
NORIKO NAGAHORI ET AL: "Inhibition of Adhesion of Type 1 Fimbriated Escherichia coli to Highly Mannosylated Ligands Shin-Ichiro Nishimura, [b]", CHEMBIOCHEM, vol. 50, no. 3, 1 January 2002 (2002-01-01), pages 836 - 844, XP055094204 *
R BOGNAR: "N-GLYKOSYL-DERIVATE 'l-F.IL XIII. DER NACHTRÄGLICHE AUSBAU DES AGLYKONS. SYNTHESE VON N-GLYKOSYL- DERIVATEN DES 2-AMINO-THIAZOLS, 2-AMINO-1,3,4-THIADIAZOLS UND 5-AMINO-1,2,3,4-THIATRIAZOLS", CARBOHYDRATE RESEARCH, vol. 5, 1 January 1967 (1967-01-01), pages 320 - 328, XP055094071 *
See also references of WO2011050323A1 *
V. S. TAILE ET AL: "Synthesis and biological evaluation of novel 2-(4-O-[beta]-D-glucosidoxyphenyl)-4,5-disubstituted imidazoles", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 47, no. 4, 17 July 2010 (2010-07-17), pages 903 - 907, XP055094097, ISSN: 0022-152X, DOI: 10.1002/jhet.433 *
W. T. HASKINS: "Reliations between Rotatory Power and Structure in the Sugar Group. XXXV. Some 2'-Naohthyl 1-Thioglycopyranosides and their Acetates", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 69, no. 7, 19 July 1947 (1947-07-19), pages 1668 - 1672, XP055094092, ISSN: 0002-7863, DOI: 10.1021/ja01199a030 *

Also Published As

Publication number Publication date
EP2490530A1 (de) 2012-08-29
EP3492483A1 (de) 2019-06-05
WO2011050323A1 (en) 2011-04-28

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Inventor name: HULTGREN, SCOTT

Inventor name: CUSUMANO, CORINNE

Inventor name: HAN, ZHENFU

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