EP2442805A4 - Nanodispersion d'un médicament et son procédé de préparation - Google Patents

Nanodispersion d'un médicament et son procédé de préparation

Info

Publication number
EP2442805A4
EP2442805A4 EP10789111A EP10789111A EP2442805A4 EP 2442805 A4 EP2442805 A4 EP 2442805A4 EP 10789111 A EP10789111 A EP 10789111A EP 10789111 A EP10789111 A EP 10789111A EP 2442805 A4 EP2442805 A4 EP 2442805A4
Authority
EP
European Patent Office
Prior art keywords
nanodispersion
drug
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10789111A
Other languages
German (de)
English (en)
Other versions
EP2442805A1 (fr
Inventor
Ajay Jaysingh Khopade
N Arulsudar
Subhas Balaram Bhowmick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sun Pharma Advanced Research Co Ltd
Original Assignee
Sun Pharma Advanced Research Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharma Advanced Research Co Ltd filed Critical Sun Pharma Advanced Research Co Ltd
Publication of EP2442805A1 publication Critical patent/EP2442805A1/fr
Publication of EP2442805A4 publication Critical patent/EP2442805A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP10789111A 2009-06-19 2010-06-18 Nanodispersion d'un médicament et son procédé de préparation Withdrawn EP2442805A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1468MU2009 2009-06-19
PCT/IN2010/000423 WO2010146606A1 (fr) 2009-06-19 2010-06-18 Nanodispersion d'un médicament et son procédé de préparation

Publications (2)

Publication Number Publication Date
EP2442805A1 EP2442805A1 (fr) 2012-04-25
EP2442805A4 true EP2442805A4 (fr) 2012-11-21

Family

ID=43355961

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10789111A Withdrawn EP2442805A4 (fr) 2009-06-19 2010-06-18 Nanodispersion d'un médicament et son procédé de préparation

Country Status (12)

Country Link
US (1) US8778364B2 (fr)
EP (1) EP2442805A4 (fr)
JP (1) JP5627039B2 (fr)
KR (1) KR20120050414A (fr)
CN (1) CN102802624A (fr)
AR (1) AR077155A1 (fr)
AU (1) AU2010261342A1 (fr)
CA (1) CA2765541A1 (fr)
EA (1) EA201270050A1 (fr)
MX (1) MX2011013726A (fr)
WO (1) WO2010146606A1 (fr)
ZA (1) ZA201109510B (fr)

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CN102970990A (zh) 2010-05-03 2013-03-13 帝国制药美国公司 非水性紫杉烷前-乳剂制剂以及制备和使用该制剂的方法
US20110293700A1 (en) 2010-05-26 2011-12-01 Selecta Biosciences, Inc. Nanocarrier compositions with uncoupled adjuvant
WO2012061717A1 (fr) 2010-11-05 2012-05-10 Selecta Biosciences, Inc. Composés nicotiniques modifiés et procédés associés
KR102009698B1 (ko) 2011-12-20 2019-08-13 바이옴 테라퓨틱스 리미티드 진균 감염의 치료를 위한 국소 오일 조성물
CN103483353B (zh) * 2012-06-13 2016-02-24 上海现代药物制剂工程研究中心有限公司 二硫杂环戊烯并吡咯酮化合物的纳米粒及制备方法
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
US9446131B2 (en) 2013-01-31 2016-09-20 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
JP6589086B2 (ja) * 2013-04-12 2019-10-16 ビョーメ セラピューティクス リミテッド 抗菌薬の組成物および製剤、その製造法および微生物感染症の治療方法
WO2015155703A2 (fr) * 2014-04-09 2015-10-15 Nanoceutica Laboratories Pvt. Ltd Composition et procédé de production d'une nanoformulation de composés bioactifs insolubles dans l'eau dans un support aqueux
WO2015184238A1 (fr) * 2014-05-30 2015-12-03 Oms Investments, Inc. Compositions de dispersion nanométrique à base d'eau et procédés de production correspondants
CN104798772B (zh) * 2015-03-13 2017-05-24 中国农业科学院农业环境与可持续发展研究所 一种农药纳米固体分散体及其制备方法
US11304898B2 (en) 2015-06-09 2022-04-19 Sun Pharma Advanced Research Company Ltd Method of treating carcinoma
CN108348468A (zh) * 2015-08-11 2018-07-31 Eyesiu医疗股份有限公司 具有生物活性亲脂性化合物的聚乙二醇化脂质纳米粒
WO2017053885A1 (fr) 2015-09-25 2017-03-30 Glaukos Corporation Implants lacrymaux à caractéristiques d'administration de médicament régulée et leurs procédés d'utilisation
WO2017129772A1 (fr) * 2016-01-29 2017-08-03 Xellia Phamaceuticals Aps Compositions pharmaceutiques stables de temsirolimus
CN114749656A (zh) * 2020-12-28 2022-07-15 航天神舟生物科技集团有限公司 一种金属纳米铁/纳米铜粒子溶液及工作液的制备方法

Citations (3)

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WO1999029300A1 (fr) * 1997-12-10 1999-06-17 Rtp Pharma Inc. Preparations autoemulsifiantes de fenofibrate
WO2001028520A1 (fr) * 1999-10-20 2001-04-26 Vesifact Ag Preconcentre a microemulsions, microemulsion et utilisation d'une composition de ce type
WO2009087678A2 (fr) * 2007-12-24 2009-07-16 Sun Pharma Advanced Research Company Limited Nanodispersion

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999029300A1 (fr) * 1997-12-10 1999-06-17 Rtp Pharma Inc. Preparations autoemulsifiantes de fenofibrate
WO2001028520A1 (fr) * 1999-10-20 2001-04-26 Vesifact Ag Preconcentre a microemulsions, microemulsion et utilisation d'une composition de ce type
WO2009087678A2 (fr) * 2007-12-24 2009-07-16 Sun Pharma Advanced Research Company Limited Nanodispersion

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2010146606A1 *

Also Published As

Publication number Publication date
EP2442805A1 (fr) 2012-04-25
US20120087959A1 (en) 2012-04-12
EA201270050A1 (ru) 2012-05-30
AR077155A1 (es) 2011-08-03
JP2012530694A (ja) 2012-12-06
ZA201109510B (en) 2012-09-26
WO2010146606A1 (fr) 2010-12-23
AU2010261342A1 (en) 2012-01-19
CA2765541A1 (fr) 2010-12-23
MX2011013726A (es) 2012-02-29
KR20120050414A (ko) 2012-05-18
JP5627039B2 (ja) 2014-11-19
CN102802624A (zh) 2012-11-28
US8778364B2 (en) 2014-07-15

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