US8778364B2 - Nanodispersion of a drug and process for its preparation - Google Patents
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- US8778364B2 US8778364B2 US13/378,758 US201013378758A US8778364B2 US 8778364 B2 US8778364 B2 US 8778364B2 US 201013378758 A US201013378758 A US 201013378758A US 8778364 B2 US8778364 B2 US 8778364B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Definitions
- the present invention relates to a ‘nanodispersion’ of a drug and process for its preparation.
- Torisel® injection which comprises temsirolimus and dehydrated alcohol (39.5% w/v), dl-alpha-tocopherol (0.075% w/v), propylene glycol (50.3% w/v), and anhydrous citric acid (0.0025% w/v), polysorbate 80 (40.0% w/v).
- TORISEL temsirolimus
- Sandimmune® Injection (cyclosporine injection, USP) available in a 5 mL sterile ampoule for I.V. administration.
- Each mL contains: cyclosporine, USP 50 mg; *Cremophor® EL (polyoxyethylated castor oil) 650 mg; alcohol, Ph. Helv 32.9% by volume which must be diluted further with 0.9% Sodium Chloride Injection or 5% Dextrose Injection before use.
- Cremophor EL a polyoxyethylated castor oil vehicle, and dehydrated ethanol USP (1:1, v/v) are used.
- solubilizers like CremophorTM EL in large amounts lead to various adverse effects such as serious or fatal hypersensitive and hypertensive reactions, bradyarrhythmia, anemia, neutropenia and/or peripheral neuropathy.
- WO2008127358A2 (hereafter referred to as '358 patent publication) discloses aqueous solutions for water insoluble drugs, with the use of phospholipid included in a lipid complex.
- the proportion of at least one phospholipid is between about 5% to about 98% of a final lipid complex (e.g., a commercially usable form) by weight.
- the amount of at least one phospholipid is between 10% to 90% by weight of the lipid complex.
- the composition of the present invention utilizes optionally phospholipids that too in very small amounts. It was found surprisingly, that the composition comprising water insoluble drugs such as the polyene antibiotics, tacrolimus, sirolimus could be effectively solubilized without the use of large amounts of phospholipids as taught by '358 patent publication.
- WO 2008144355 A2 discloses a stable oral liquid fenofibrate formulations that include a fenofibrate component and a pharmaceutically acceptable liquid carrier that is present in an amount sufficient to solubilize the fenofibrate and that includes a lipophilic component, a surfactant component, at least one monohydric alcohol, and optionally in some embodiments an aqueous component, wherein the formulation is substantially free of an oily phase.
- stable liquid fenofibrate formulations including a prophylactically or therapeutically effective amount of fenofibrate and a liquid carrier present in less than 5 ml that is sufficient to maintain dissolution of the fenofibrate under ambient temperature.
- the formulation disclosed herein are free of oily phase, the publication teaches that the formulation can contains a lipophilic component comprising at least one triglyceride of one or more fractionated vegetable fatty acids including C to C10; a surfactant component wherein the surfactant has a HLB value of greater than 10 in amounts as high as 30 percent to about 70 percent, preferably from about 42.5 percent to about 65 percent and/or from about 46 percent to about 57.5 percent. The presence of such high amounts of surfactant may not be desirable for the above reasons discussed.
- Patent application '339 claims a pharmaceutical formulation of a fibrate with improved oral bioavailability comprising a fibrate selected from fenofibrate, derivative of fenofibrate or mixtures thereof dissolved in a water miscible fibrate solubilizer selected from N-alkyl derivative of 2-pyrrolidone, ethylene glycol monoether, C 8-12 fatty acid ester of polyethylene glycol, fatty acids and combinations thereof; wherein the fibrate to solubilizer weight ratio is between about 1:1 and about 1:100.
- a composition that is using very, very low amounts of surfactant.
- a nanodispersion comprising nanoparticles having a mean size less than 300 nm dispersed in a vehicle comprising a water miscible solvent and water, said nanoparticles comprising a drug, a polymer and very low amount of surfactants and further is substantially free of phospholipids.
- a nanodispersion comprising nanoparticles having a mean size less than 300 nm dispersed in a vehicle comprising a water miscible solvent and water, said nanoparticles comprising one or more drugs, a polymer and a surfactant comprising a mixture of fatty acids or its salts and sterol or its derivatives or its salts.
- the water miscible solvent is selected from alcohols, glycols and its derivatives, polyalkylene glycols and its derivatives, glycerol, glycofurol and combinations thereof.
- water miscible solvent is selected from the group consisting of alcohol and polyethylene glycol (PEG).
- polyvinylpyrrolidone used has a molecular weight in the range of 1000 to about 50,000 and is used in the amount ranging from 0.001% w/v to 10% w/v.
- sterol or its derivatives or its salts is selected from the group consisting of cholesterol, cholesteryl esters of polar acids, phytosterols, bile acids their derivative, salts and mixtures thereof.
- Nanoparticles as described in A above wherein the polar acid is selected from the group consisting of succinic acid, hemisuccinic acid, sulfuric acid, phosphoric acid, glutamic acid and aspartic acid, boric acid.
- a solution comprising one or more drugs, a polymer and a surfactant comprising a mixture of fatty acids or its salts and sterol or its derivatives or salts thereof in a water miscible solvent, which on dilution with an aqueous liquid vehicle gives a nanodispersion.
- Nanoparticles having a mean particle size less than 300 nms comprising one or more drugs, surfactant comprising a mixture of and fatty acid or it salts and sterol or its derivatives or its salts and a polymer.
- the present invention provides a nanodispersion comprising nanoparticles having a mean particle size less than 300 nm dispersed in a vehicle comprising a water miscible solvent and water, said nanoparticles comprising one or more drugs, a polymer and a surfactant comprising a mixture of fatty acids or its salts and a sterol or its derivatives or its salts.
- the present invention also provides a solution comprising one or more drugs, a polymer and a surfactant comprising a mixture of fatty acids or its salts and sterol or its derivatives or its salts in a water miscible solvent, which upon dilution with an aqueous liquid vehicle gives nanodispersion.
- the present invention also provides nanoparticles having a mean particle size less than 300 nms comprising one or more drugs, surfactant comprising a mixture of sterol or its derivatives or its salts and fatty acid or its salts and a polymer.
- the present invention provides a nanodispersion comprising nanoparticles having a mean particle size less than 300 nm dispersed in an aqueous vehicle comprising a water miscible solvent and water, said nanoparticles comprising a drug, a polymer and a surfactant comprising a mixture of fatty acids or its salts and sterol or its derivatives or its salts.
- the present invention also provides a solution comprising a drug, a polymer and a surfactant comprising a mixture of fatty acids or its salts and sterol or its derivatives or its salts in a water miscible solvent, which upon dilution with an aqueous vehicle gives nanodispersion.
- the present invention also relates to nanoparticles having a mean particle size less than 300 nms comprising drug, surfactant comprising a mixture of sterol or its derivatives or its salts and fatty acid or it salts and a polymer.
- the nanodispersion of the present invention is devoid of toxic excipients like Cremophor and involves the use of much reduced amounts of additives (like surfactants and phospholipids) required for formulating a stable nanodispersion of drug, thus minimizing the associated toxic reactions.
- nanoparticle as used herein means any particle having controlled dimensions of the order of nanometers.
- the nanoparticles as claimed in the present invention can be a polymeric nanoparticle (matrix of polymer entrapping the drug) and/or a polymeric nanovesicle (polymer stabilized nano sized vesicle encapsulating the drug.) and/or a polymeric nanocapsule (polymeric membrane surrounding drug in core) and/or nano sized particles of the drug stabilized by surfactants, and the like having mean size less than 300 nm.
- the particle size of the nanoparticles is determined using conventional methods of measuring and expressing particle size like Malvern particle size analysis; sieving, light scattering optical microscopy, image analysis, sedimentation and such other methods known to one skilled in the art.
- Particle size distribution information can be obtained from the values D 10 , D 50 , and D 90 , such as can be generated from a Malvern particle size determination
- the applicants believe that the delivery of drug through nanodispersion comprising nanoparticles having mean size less than 300 nm, leads to enhanced internalization and accumulation of the drug in the target tumor tissues and cells. Such increased internalization levels provides a potent treatment strategy for curing tumors associated with cancer.
- the particle size of the nanoparticles is in the range of 10 nm to 275 nm. In preferred embodiments of the present invention, the particle size is less than 200 nm. In most preferred embodiments of the present invention, the particle size is in the range of 10 nm to 200 nm.
- the present invention provides a nanodispersion comprising nanoparticles having a mean size less than 300 nm dispersed in a vehicle comprising a water miscible solvent and water, said nanoparticles comprising one or more active agents, a polymer and a surfactant comprising a mixture of fatty acids or its salts and sterol or its derivatives or its salts.
- the present invention also provides a solution comprising one or more drugs, a polymer and a surfactant comprising a mixture of fatty acids or its salts and sterol or its derivatives or its salts in a water miscible solvent, which upon dilution with an aqueous liquid vehicle gives nanodispersion.
- the nanoparticles of the present invention have a mean particle size less than 300 nms, wherein the said particles comprises one or more drugs, surfactant comprising a mixture of sterol or its derivatives or its salts and fatty acid or it salts and a polymer.
- the drug derivative are preferably the drugs that are poorly water soluble drugs, such as sirolimus, tacrolimus, cyclosporine, fenofibrate.
- these drugs are poorly water soluble and poses a problem of physically unstable due to either crystallization or aggregation problem leading to inadequate bioavailability when administered either orally or parenterally.
- the nanoparticles of the present invention comprise one or more polymers.
- the polymer(s) that are suitable for the nanoparticles of the present invention are preferably, water soluble.
- Polyvinylpyrrolidone one of the water soluble polymer is a tertiary amide polymer having linearly arranged monomer units of 1-vinyl-2-pyrrolidone, hereinafter designated PVP, and also known as Povidone. It is commercially available as a series of products having mean molecular weights ranging from about 10,000 to about 700,000. The various products are marketed according to average molecular weights designated K-values; e.g. GAF Corporation supplies PVP having the following K-values:
- BASF provides different water soluble grades of polyvinyl pyrrolidone as Kollidon with grades having for eg, molecular weight of 2000 to 3000 (Kollidon 12 PF), 7000-11,000 (Kollidon 17 PF), 28,000-34,000 (Kollidon 25), 1,000,000-1,5000,000 (Kollidon 90 F).
- polyvinylpyrrolidone is used as a water soluble polymer.
- the grades of polyvinylpyrrolidone suitable for the present invention include grades having a molecular weight in the range from about 1,000 to about 45,000, preferably, from about 4,000 to about 30,000.
- the amount of polymer used in the nano-dispersion ranging from about 0.001% w/v to about 20% w/v.
- the polymer is preferably used in an amount ranging from about 0.01% w/v to about 5.0% w/v. Most preferably, it is used in an amount ranging from about 0.01% w/v to about 1.0% w/v.
- the nanodispersion of the present invention comprises one or more surfactants.
- surfactant is a blend of “surface active agent”.
- Surfactants are molecules, which comprises a water-soluble (hydrophilic) and a lipi-soluble (lipophilic) part.
- the surfactants that are used in the nanodispersion of the present invention comprises a mixture of fatty acid or its salts and sterol or its derivatives or its salts.
- fatty acids includes aliphatic (saturated or unsaturated) monocarboxylic acids derived from or contained in esterified form, in an animal or vegetable fat, oil or wax.
- fatty acids or its salts that may be used in the compositions of the present invention include but are not limited to fatty acids or its salts having ‘n’ number of carbon atoms wherein ‘n’ ranges from about 4 to about 28.
- the fatty acid may be a saturated fatty acid or an unsaturated fatty acid, and their salt and combinations thereof.
- the saturated fatty acid and its salts may be selected from butyric acid, caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid, behenic acid, sodium caprylate, sodium laurate, sodium myristate, sodium palmitate and the like and/or mixtures thereof.
- the unsaturated fatty acid and its salts may be selected from myristoleic acid, palmitoleic acid, oleic acid, linoleic acid, alpha linolenic acid, arachidonic acid, eicosapentaenoic acid, erucic acid, docosahexaenoic acid, sodium oleate, sodium arachidonate and the like and/or mixtures thereof.
- sterol or its derivative or its salts that may be used in the nanodispersion or nanoparticles of the present invention may be acid esters of sterols.
- the sterols that may be suitable according to the present invention include, but are not limited to, cholesterol, phytosterols, ergosterol, bile acids salts and mixtures thereof.
- Acid salts of cholesterol include, but are not limited to, cholesteryl sulfate, cholesterol acetate, cholesterol chloroacetate, cholesterol benzoate, cholesterol myristate, cholesterol hemisuccinate, cholesterol phosphate, cholesterol phosphate, phosphonate, borate, nitrate, cholesterol cinnamate, cholesterol crotanoate, cholesterol butyrate, cholesterol heptanoate, cholesterol hexanoate, cholesterol octanoate, cholesterol nonanoate, cholesterol decanoate, cholesterol oleate, cholesterol propionate, cholesterol valerate, dicholesteryl carbonate and the like and mixtures thereof.
- Phytosterols that may be used in the compositions of the present invention include sitosterol, campesterol, stigmasterol, brassicasterol and its derivatives, salts and mixture thereof.
- Phytosterols* marketed by Sigma, U.S.A. containing bsitosterol, campesterol and dihydrobrassicasterol.
- Bile acids include cholic acid, chenodeoxycholic acid, deoxycholic acid, glycocholic acid, taurocholic acid, ursodeoxycholic acid and its derivatives, salts and mixture thereof.
- the sterols can also be esters of cholesterol including cholesterol hemi-succinate, salts of cholesterol including cholesterol hydrogen sulfate and cholesterol sulfate, ergosterol, esters of ergosterol including ergosterol hemi-succinate, salts of ergosterol including ergosterol hydrogen sulfate and ergosterol sulfate, lanosterol, esters of lanosterol including lanosterol hemi-succinate, salts of lanosterol including lanosterol hydrogen sulfate and lanosterol sulfate.
- the nanoparticles comprise a surfactant which is a mixture of sterol or its derivatives or its salts and fatty acids or its salts.
- the nanoparticles comprise of cholesterol ester of polar acids.
- the surfactant used in the nanodispersion is a mixture of caprylic acid and cholesteryl sulfate.
- Caprylic acid, also known as octanoic acid may be used in the embodiments in an amount ranging from about 0.001% w/v to about 5.0% w/v, more preferably from about 0.01% w/v to about 1.0% w/v and most preferably from about 0.01% w/v to about 0.5% w/v.
- Cholesteryl sulfate is used in the embodiments of the present invention in an amount ranging from about 0.001% w/v to about 5.0% w/v, more preferably from about 0.01% w/v to about 1.0% w/v and most preferably from about 0.01% w/v to about 0.5% w/v.
- the surfactant used is selected from oleic acid and cholesteryl sulphate and/or mixtures thereof.
- the surfactant used is selected from saturated fatty acid and bile acid or bile salt and/or mixtures thereof.
- the surfactant used is selected from the group consisting of caprylic acid and sodium glycocholate or ursodeoxycholic acid and/or mixtures thereof.
- Bile salts when used are employed in an amount ranging from about 0.001% w/v to about 5.0% w/v, more preferably from about 0.01% w/v to about 1.0% w/v and most preferably from about 0.01% w/v to about 0.75% w/v.
- compositions of the present invention may further comprise very low amounts of lecithins/phospholipids and/or their derivatives.
- low amounts means that the ratio of phospholipids' to drug is about 1:4 to about 1:10, that even if phospholipids are used they are used in very low amount i.e compared to the amount of drug the amount of phospholipids is very low.
- the prior art compositions that are liposomal require large amounts of phospholipids compared to the amount of the drug.
- the examples of such phospholipids include, but are not limited to, lecithins natural, partially hydrogenated or hydrogenated lecithin or sphingolipids. Natural lecithins inturn are mixtures of different phospholipids.
- the phospholipids that may be used in the compositions of the present invention is selected from phosphatidyl choline, (dimyristoylphosphatidyl choline, dipalmitotylphosphatidyl choline, distearyloylphosphatidyl choline, dioleoylphosphatidyl choline, dilauryloylphosphatidyl choline, 1-palmitoyl-phosphatidyl choline, 1-myristoyl-2-palmitoyl phosphatidyl choline; 1-palmitoyl-2-myristoyl phosphatidyl choline, 1-stearoyl-2-palmitoyl phosphatidyl choline); phosphatidyl ethanolamine (dimyristoyl phosphatidyl ethanolamine, dipalmitoyl phosphatidyl ethanolamine, distearoyl phosphatidyl ethanolamine, lysophat
- polyethylene glycol derivatives of lipids such as polyethylene glycol-distearoyl phosphatidylethanolamine (PEG-DSPE), methoxypolyethylene glycol-distearoyl phosphatidylcholine m-PEG-DSPC and the like and mixtures thereof may also be used in the compositions of the present invention.
- PEG-DSPE polyethylene glycol-distearoyl phosphatidylethanolamine
- methoxypolyethylene glycol-distearoyl phosphatidylcholine m-PEG-DSPC and the like and mixtures thereof may also be used in the compositions of the present invention.
- the butylenesids that may be used in the compositions of the present invention is m-PEG-DSPE (methoxy polyethylene glycol-disteroyl phosphatidyl ethanolamine).
- the phospholipid used is—mPEG-DSPE. It is used in an amount ranging from about 0.001% w/v to about 10.0% w/v, more preferably from about 0.01% w/v to about 5.0% w/v and most preferably from about 0.03% w/v to about 0.5% w/v.
- the non-aqueous solvent used in the compositions of the present invention is one in which the drug is relatively soluble.
- the non aqueous solvent is miscible with water or aqueous solvents.
- water miscible solvents used in the present invention includes, but are not limited to, alcohols such as ethanol, n-propanol, isopropanol; glycols such as ethylene glycol, propylene glycol, butylene glycol and its derivatives; polyethylene glycols like PEG 400 or PEG 3350; polypropylene glycol and its derivatives such as PPG-10 butanediol, PPG-10 methyl glucose ether, PPG-20 methyl glucose ether, PPG-15 stearyl ether; glycerol; glycofurol and the like and mixtures thereof.
- the non-aqueous solvent may be selected from the group consisting of alcohols, polyethylene glycols and/or mixtures thereof.
- a mixture of ethanol and PEG polyethylene glycol
- Ethanol is used in the nanodispersion composition of the present invention in an amount ranging from about 0.001% w/v to about 5% w/v, more preferably from about 0.05% w/v to about 0.5% w/v and most preferably from about 0.1% w/v to about 0.25% w/v.
- PEG-400 is used in the embodiments of the present invention in an amount ranging from about 0.01% w/v to about 20.0% w/v, more preferably from about 0.05% w/v to about 5.0% w/v and most preferably from about 1.0% w/v to about 2.5% w/v.
- PEG-3350 is used, in the embodiments of the present invention in an amount ranging from about 0.001% w/v to about 10.0% w/v, more preferably from about 0.05% w/v to about 5.0% w/v and most preferably from about 0.1% w/v to about 3% w/v.
- a drug pre-concentrate i.e the solution upon dilution with the aqueous vehicle gives a nanodispersion that remains stable for at least about 4 hours. This time is the time during which the nanodispersion may be administered to the patient in the form of infusion. Thus, it is always desirable to achieve minimum of 4 hours stability of the nanodispersion of the present invention.
- the vehicle may further comprise about 5% to about 10.0% w/v dextrose solution in water for injection or any other pharmaceutically acceptable intravenous aqueous liquid vehicle and mixtures thereof.
- the aqueous vehicle further comprises 5% dextrose solution in order to improve this stability but additional stabilizers may also be present in the aqueous phase.
- additional stabilizers are hetastarch, dextran, sodium hyaluronate, glutathione, ornithin-L-aspartate and the like and mixtures thereof.
- the solution of the present invention as claimed may be designed for oral administration.
- the solution also referred to as pre-concentrate may be filled into hard or soft gelatin capsules.
- the solution is dispersed in the aqueous medium and therefore, the drugs like fenofibrate are dispersed in the form of nanoparticles having a particle size in the nanometer range, sufficient to provide adequate dissolution.
- the nanodispersion vehicle allows the drug particles to remain in the dispersion, physically stable for a desired period of time, for example, 1 hour to 3 hours which is sufficient for the drug to be absorbed into the body, when the nanodispersion is administered orally.
- the solution may be dried to form nanoparticles.
- the nanoparticles may be formulated along with pharmaceutically acceptable excipients to form solid dosage form like tablet, granules, pellets.
- the nanodispersion of drug of the present invention may be typically prepared by any one of the processes listed below:
- the therapeutically active ingredient (and/or other agents), polymer(s) and surfactant(s) selected from fatty acids or its salts, sterol or its derivatives or its salts and mixtures thereof is dissolved in water misbicle solvent such as ethanol and/or PEG, along with stirring and heating to obtain a concentrated solution of the drug.
- the solution so obtained is filtered through a membrane filter.
- an aqueous liquid vehicle 5% dextrose solution
- the nanodispersion so formed is optionally homogenized and/or sonicated, filtered or lyophilized.
- the lyophilized powder of the medicament can be reconstituted with the aqueous medium, reforming nanodispersion of the present invention, prior to administration to the patients.
- the drug, polymer(s) and surfactant(s) selected from fatty acids or its salts, sterol or its derivatives or its salts and mixtures thereof is dissolved in water miscible solvent such as ethanol and/or PEG along with stirring and heating to obtain a concentrated solution of the drug.
- the solution so obtained is filtered through a membrane filter and is added to an aqueous medium (5% dextrose solution) and the mixture is shaken/agitated, thus leading to the formation of the nanodispersion of the present invention.
- the nanodispersion so formed is optionally homogenized and/or sonicated, filtered or lyophilized.
- the lyophilized powder of the medicament can be reconstituted with the aqueous medium, reforming nanodispersion of the present invention, prior to administration to the patients.
- drug and surfactant(s) comprising a mixture of fatty acids or its salts and sterol or its derivatives or its salts is dissolved in water miscible solvent such as ethanol and/or PEG by slightly warming at 40° C. in a round bottomed flask, and the solvent is evaporated to form a thin film of the drug.
- the polymer(s) is dissolved in required quantity of an aqueous medium and this solution is added to the film with gentle agitation and shaking for 3-4 hours, thus leading to the formation of the nanodispersion of the present invention.
- the nanodispersion so formed is optionally homogenized and/or sonicated, filtered and lyophilized.
- the lyophilized powder of the medicament can be reconstituted with the aqueous medium, reforming nanodispersion of the present invention prior to administration to the patients.
- the nanodispersion of the present invention is a colloidal nanodispersion of drug comprising nanoparticles having a mean size less than 300 nm, they were analyzed for physical and chemical stability. It was observed that the particles do not aggregate upon storage at room temperature for about 8 hours to 24 hours and the nanodispersion shows no sign of change in appearance, inferring that the nanodispersion is stable for the desired period of time before and during administration.
- the nanodispersion of the present invention can be provided as a kit having two or more containers, for example two containers, wherein the first container comprising a solution of a drug, a polymer and a surfactant comprising a mixture of fatty acids or its salts and sterol or its derivatives or its salts in a water miscible solvent, and a second container comprising an aqueous liquid vehicle, such that on addition of contents of second container to the contents of the first container or vice versa, with mild agitation or shaking, results in the formation of nanodispersion of the present invention and is suitable for intravenous administration.
- An additional container may contain a third component for mixing prior to formation of drug nanodispersion or after nanodispersion of the said drug is formed.
- the present invention also provides a kit having two containers, the first container comprising a lyophilized form of the nanodispersion and a second container comprising an aqueous liquid vehicle such that prior to administration to the patients, the contents of second container can be added to the contents of the first container or vice versa with mild agitation or shaking, resulting in the formation of nanodispersion of the present invention.
- Administering the nanodispersion of the present invention to patients in need thereof, will provide an efficient method of treatment of various types of cancers known in the art.
- Drug, cholesteryl sulfate, caprylic acid and PVP K-12 were weighed accurately in a glass vessel. Contents were dissolved in the required quantity of absolute ethanol and PEG-400 with stirring to obtain a concentrated drug solution. The solution was filtered through 0.2 ⁇ PVDF membrane filter. The required amount of the preconcentrate was dispersed in the dextrose solution (5% w/v) (50 ml) with gentle shaking to get a transparent to transluscent nanodispersion of drug having dilution of 0.1 mg/ml. Nanodispersion was analyzed for the following tests: Appearance, pH (Mettler Toledo-seven easy, pH Meter) and Particle size (Nano-ZS, Malvern Particle size analyzer), described below.
- the pre-concentrate so prepared was found to be clear colorless slightly viscous solution. It was mixed with the aqueous phase such as dextrose solution to achieve a nanodispersion. The stability of the nanodispersion in terms of the particle size of the dispersed particles was determined initially as well as on storage for few hours.
- Drug, cholesteryl sulfate, caprylic acid and PVP K-17 were weighed accurately in a glass vessel. Contents were dissolved in the required quantity of absolute ethanol and PEG-400 with stirring to obtain a concentrated drug solution. The solution was filtered through 0.2 ⁇ PVDF membrane filter. Required amount of the preconcentrate was dispersed in the Dextrose solution (5% w/v) (50 ml) with gentle shaking to get a transparent to transluscent nanodispersion of drug having dilution of 0.5 mg/ml. Nanodispersion was analyzed for the following tests: Appearance, pH (Mettler Toledo-seven easy, pH Meter) and Particle size (Nano-ZS, Malvern Particle size analyzer), described below.
- the pre-concentrate so prepared is found to be clear colorless slightly viscous solution. It was mixed with the aqueous phase such as dextrose solution to achieve a nanodispersion. The stability of the nanodispersion in terms of the particle size of the dispersed particles was determined initially as well as on storage for few hours.
- Quantity Quantity Ingredients (% w/w) (mg/g) Fenofibrate 14.5 145 Caprylic Acid 12.0 120 Sodium Cholesteryl Sulfate 1.0 10 Povidone (K-12) 1.2 12 Dehydrated Alcohol 14.5 145 Polyethylene Glycol 400 qs to 100 qs to 1000
- Sodium cholesteryl sulfate, caprylic acid, and Povidone (K-12) were weighed accurately in a glass vessel. Contents were dissolved in the required quantity of Absolute Alcohol and PEG-400 with stirring to obtain a clear concentrated drug solution. The solution was filtered through 0.2 ⁇ PVDF membrane filter. The pre-concentrate so prepared was found to be clear colorless slightly viscous solution. The required amount of the preconcentrate was dispersed in the dextrose solution (5% w/v) with gentle shaking to get a white transluscent nanodispersion of drug having dilution of 5.0 mg/ml.
- Nanodispersion was analyzed for the following tests: Appearance, pH (Mettler Toledo-seven easy, pH Meter) and Particle size (Nano-ZS, Malvern Particle size analyzer), described below.
- the stability of the nanodispersion in terms of the particle size of the dispersed particles was determined initially as well as on storage ie. after 1 h.
- Quantity Quantity Ingredients (% w/w) (mg/g) Tacrolimus 6 60 Caprylic Acid 0.5 5.0 Sodium Cholesteryl Sulfate 0.40 4.0 Povidone (K-17) 5.0 50 Dehydrated Alcohol 6 60 Polyethylene Glycol 400 qs to 100 qs to 1000
- the stability of the nanodispersion in terms of the particle size of the dispersed particles was determined initially as well as on storage i.e after 24 h.
- Quantity Quantity Ingredients (% w/w) (mg/g) Brinzolamide 3 30 Caprylic Acid 0.67 6.7 Sodium Cholesteryl Sulfate 0.67 6.7 Povidone (K-17) 7.5 75 Dehydrated Alcohol 9 90 Polyethylene Glycol 400 qs to 100 qs to 1000
- Sodium cholesteryl sulfate, caprylic acid, and Povidone (K-17) were weighed accurately in a glass vessel. Contents were dissolved in the required quantity of Absolute Alcohol and PEG-400 with stirring and by heating at 60° C. to obtain a clear concentrated drug solution. The solution was filtered through 0.2 ⁇ PVDF membrane filter. The pre-concentrate so prepared was found to be clear colorless to pale yellow slightly viscous solution. The required amount of the preconcentrate was dispersed in 0.25% Hypromellose (HPMC) solution with gentle shaking to get a nanodispersion of drug having dilution of 1.0 mg/ml.
- HPMC Hypromellose
- Nanodispersion was analyzed for the following tests: Appearance, pH (Mettler Toledo-seven easy, pH Meter) and Particle size (Nano-ZS, Malvern Particle size analyzer), described below. The particle size of the nanodispersion was determined initially as well as on storage till 2 h.
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IN1468MU2009 | 2009-06-19 | ||
PCT/IN2010/000423 WO2010146606A1 (fr) | 2009-06-19 | 2010-06-18 | Nanodispersion d'un médicament et son procédé de préparation |
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EP (1) | EP2442805A4 (fr) |
JP (1) | JP5627039B2 (fr) |
KR (1) | KR20120050414A (fr) |
CN (1) | CN102802624A (fr) |
AR (1) | AR077155A1 (fr) |
AU (1) | AU2010261342A1 (fr) |
CA (1) | CA2765541A1 (fr) |
EA (1) | EA201270050A1 (fr) |
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WO2017053885A1 (fr) | 2015-09-25 | 2017-03-30 | Glaukos Corporation | Implants lacrymaux à caractéristiques d'administration de médicament régulée et leurs procédés d'utilisation |
US10166206B2 (en) | 2013-01-31 | 2019-01-01 | Sebela International Bermuda Limited | Topical compositions and methods for making and using same |
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US10232047B2 (en) | 2011-12-20 | 2019-03-19 | Vyome Biosciences Private Limited | Topical oil composition for the treatment of fungal infections |
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IN2014CH01872A (fr) | 2014-04-09 | 2015-05-08 | Nanoceutica Lab Pvt Ltd | |
US20170099833A1 (en) * | 2014-05-30 | 2017-04-13 | Oms Investments, Inc. | Nano-sized water-based dispersion compositions and methods of making thereof |
CN104798772B (zh) * | 2015-03-13 | 2017-05-24 | 中国农业科学院农业环境与可持续发展研究所 | 一种农药纳米固体分散体及其制备方法 |
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WO2017129772A1 (fr) * | 2016-01-29 | 2017-08-03 | Xellia Phamaceuticals Aps | Compositions pharmaceutiques stables de temsirolimus |
CN114749656A (zh) * | 2020-12-28 | 2022-07-15 | 航天神舟生物科技集团有限公司 | 一种金属纳米铁/纳米铜粒子溶液及工作液的制备方法 |
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2010
- 2010-06-18 CN CN2010800270138A patent/CN102802624A/zh active Pending
- 2010-06-18 US US13/378,758 patent/US8778364B2/en active Active
- 2010-06-18 EA EA201270050A patent/EA201270050A1/ru unknown
- 2010-06-18 CA CA2765541A patent/CA2765541A1/fr not_active Abandoned
- 2010-06-18 WO PCT/IN2010/000423 patent/WO2010146606A1/fr active Application Filing
- 2010-06-18 JP JP2012515633A patent/JP5627039B2/ja active Active
- 2010-06-18 EP EP10789111A patent/EP2442805A4/fr not_active Withdrawn
- 2010-06-18 MX MX2011013726A patent/MX2011013726A/es not_active Application Discontinuation
- 2010-06-18 AU AU2010261342A patent/AU2010261342A1/en not_active Abandoned
- 2010-06-18 KR KR1020117030828A patent/KR20120050414A/ko not_active Application Discontinuation
- 2010-06-22 AR ARP100102179A patent/AR077155A1/es unknown
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10166206B2 (en) | 2013-01-31 | 2019-01-01 | Sebela International Bermuda Limited | Topical compositions and methods for making and using same |
US10729667B2 (en) | 2013-01-31 | 2020-08-04 | Sebela Ireland Limited | Topical compositions and methods for making and using same |
WO2016199169A1 (fr) | 2015-06-09 | 2016-12-15 | Sun Pharma Advanced Research Company Ltd | Picn-01 |
WO2017053885A1 (fr) | 2015-09-25 | 2017-03-30 | Glaukos Corporation | Implants lacrymaux à caractéristiques d'administration de médicament régulée et leurs procédés d'utilisation |
Also Published As
Publication number | Publication date |
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KR20120050414A (ko) | 2012-05-18 |
CN102802624A (zh) | 2012-11-28 |
ZA201109510B (en) | 2012-09-26 |
JP5627039B2 (ja) | 2014-11-19 |
EP2442805A1 (fr) | 2012-04-25 |
MX2011013726A (es) | 2012-02-29 |
AR077155A1 (es) | 2011-08-03 |
EA201270050A1 (ru) | 2012-05-30 |
WO2010146606A1 (fr) | 2010-12-23 |
AU2010261342A1 (en) | 2012-01-19 |
CA2765541A1 (fr) | 2010-12-23 |
EP2442805A4 (fr) | 2012-11-21 |
US20120087959A1 (en) | 2012-04-12 |
JP2012530694A (ja) | 2012-12-06 |
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