EP2393533B1 - Dispositifs d'administration de médicament - Google Patents
Dispositifs d'administration de médicament Download PDFInfo
- Publication number
- EP2393533B1 EP2393533B1 EP10702138.8A EP10702138A EP2393533B1 EP 2393533 B1 EP2393533 B1 EP 2393533B1 EP 10702138 A EP10702138 A EP 10702138A EP 2393533 B1 EP2393533 B1 EP 2393533B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- cartridge
- bung
- sensor
- piston rod
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims description 70
- 229940090047 auto-injector Drugs 0.000 claims description 3
- 238000012377 drug delivery Methods 0.000 description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 229940079593 drug Drugs 0.000 description 3
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- 229940126601 medicinal product Drugs 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010061296 Motor dysfunction Diseases 0.000 description 1
- 206010057362 Underdose Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000000122 growth hormone Substances 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229940127215 low-molecular weight heparin Drugs 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
- A61M5/14546—Front-loading type injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M2005/31588—Constructional features or modes of drive mechanisms for piston rods electrically driven
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/14—Detection of the presence or absence of a tube, a connector or a container in an apparatus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3327—Measuring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
- A61M5/14566—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for receiving a piston rod of the pump
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31546—Electrically operated dose setting, e.g. input via touch screen or plus/minus buttons
Definitions
- This invention relates to medicament delivery devices for delivering medicine to the human or animal body and in particular to electronically controlled auto-injectors having a replaceable medicament cartridge. Such devices are commonly used by those with diabetes for the administration of insulin.
- Medicament delivery devices are routinely used by persons without formal medical training, i.e. patients where self-management of their condition is increasingly common. These circumstances set a number of requirements for medicament delivery devices of this kind.
- the injector should be robust in construction, yet easy to use in terms of its operation by a user and the manipulation of the parts. In the case of those with diabetes, many users will be of impaired vision and may also be physically infirm. Devices that are too large or cumbersome may therefore prove difficult to use, particularly someone with reduced dexterity.
- US Patent Specification 5,989,221 describes an electronically controlled injection device in which the readying of the device for administering and the subsequent drug delivery therefrom is controlled by an electronic control unit.
- the control unit comprises a position or attitude sensor for transmitting a signal so that the readying of the device cannot take place unless the longitudinal axis of the injection cartridge is in a predetermined direction. This is in the context of removing air or mixing drug components.
- the control unit is also operative for driving a piston rod a predetermined distance for delivery of a drug dose.
- a medicament delivery device for delivering a medicament to a patient
- the medicament delivery device comprises: a housing; a holder within the housing for receiving a medicament cartridge; a piston rod for driving a bung of the medicament cartridge; a drive mechanism including a motor for providing an output drive to the piston rod for delivering the medicament; and control means for controlling operation of the device; a bung sensor is provided for sensing when the piston rod is in contact with the bung; wherein the control means is operative for advancing drive of the piston rod towards the bung,
- the control means is operative for advancing the drive of the piston rod until the bung sensor senses that the piston rod is in contact with the bung.
- a latch sensor is provided for sensing the position of the holder as the holder moves from an open position to a closed position.
- the control means is operative for advancing the drive of the piston rod only when the latch sensor senses the holder is in the closed position.
- a cartridge sensor is provided for sensing the presence of a medicament cartridge in the holder.
- the control means is operative for advancing the drive of the piston rod when the cartridge sensor senses the presence of the medicament cartridge and the latch sensor senses that the holder is in a closed position.
- the control means is operative to stop further advancement of the piston rod: a) when the bung sensor senses that the piston rod is in contact with the bung; or b) when the cartridge has moved to a seated position within the housing after initial contact between the piston rod and the bung.
- the force needed to actuate the bung sensor is greater than the sliding friction between the cartridge and the holder.
- the holder may include a door of the medicament delivery device.
- the control means may be operative for advancing the piston rod drive when the cartridge sensor senses that the medicament cartridge is in a predetermined (i.e. 'correct' or 'seated') position relative to the holder to deliver a dose of medicament.
- the latch sensor and the bung sensor may each generate sensor signals that are combined so that the combined signal sent to the control means indicates that the cartridge is present and/or in the correct position when the piston rod contacts the cartridge bung.
- control means is operative to backwind the piston rod by a predetermined amount when the bung sensor senses that the piston rod is in contact with the bung. This is advantageous in the case where the bung sensor is in the form of a dome switch or other pressure switch (including solid state switches and pressure switches), thus leaving the dome switch in an open position.
- the control means drives the piston rod by an amount that compensates for this backwind.
- any one or all of the cartridge, latch and bung sensors may be switches that signal their respective sensing function to the control means.
- Embodiments of the present invention are advantageous in that the medicament delivery device automatically advances the piston rod towards the cartridge bung when a cartridge is present and the door/holder of the injector is closed. This simplifies the number of operations for the user, including avoiding a need for the user to dial an air-shot dose to position the piston rod against the bung. Battery life is saved by avoiding drive of the piston rod when no cartridge is present. As the cartridge is properly or fully seated within the holder, a further advantage is that the likelihood of under-dosing following insertion of a new or used cartridge is reduced.
- the term "medicament delivery device” shall mean a single-dose or multi-dose or pre-set dose or pre-defined, disposable or re-useable device designed to dispense a user selectable or pre-defined dose of a medicinal product, preferably multiple doses, e.g. insulin, growth hormones, low molecular weight heparins, and their analogues and/or derivatives etc.
- Said device may be of any shape, e.g. compact or pen-type.
- Dose delivery may be provided through a mechanical (optionally manual) or electrical drive mechanism or stored energy drive mechanism, such as a spring, etc.
- Dose selection may be provided through a manual mechanism or electronic mechanism.
- said device may contain components designed to monitor physiological properties such as blood glucose levels, etc.
- the said device may comprise a needle or may be needle-free.
- the term "medicament delivery device” may refer to a needle-based device providing multiple doses having an electrical drive mechanism, which is designed for use by persons without formal medical training such as patients.
- the drug delivery device is of the automated-type, i.e. an auto-injector.
- housing shall preferably mean any exterior housing ("main housing”, “body”, “shell”) or interior housing ("insert”, “inner body”) having a unidirectional axial coupling to prevent proximal movement of specific components.
- the housing may be designed to enable the safe, correct, and comfortable handling of the drug delivery device or any of its mechanism. Usually, it is designed to house, fix, protect, guide, and/or engage with any of the inner components of the drug delivery device (e.g., the drive mechanism, cartridge, plunger, piston rod) by limiting the exposure to contaminants, such as liquid, dust, dirt etc.
- the housing may be unitary or a multipart component of tubular or non-tubular shape.
- the exterior housing serves to house a cartridge from which a number of doses of a medicinal product may by dispensed.
- motor shall preferably mean any motorised means for driving the gearing system and ultimately the input drive means.
- a stepper motor is preferably utilised although any means for driving the gearing system or the drive means, including a mechanical or manual actuation means, may also be incorporated into the device.
- proximal end of the device or a component of the device shall mean the end, which is furthest away from the dispensing end of the device.
- distal end of the device or a component of the device shall mean the end, which is closest to the dispensing end of the device.
- Devices embodying the invention may be usefully deployed in re-useable medicament delivery devices that comprise replaceable medicament cartridges and may also be deployed within an auto-injector device.
- a medicament delivery device 1 comprises a case 2 having a display 3 for displaying functional information relating to the operation of the medicament delivery device, including the set dose, number of doses remaining in the medicament cartridge.
- User interface buttons 4, 5 and 6 are provided to allow the user to operate the injector including priming, setting a dose, opening a medicament cartridge holder and door 7, and activating the dispensing of the set dose.
- a threaded needle attachment 8 is provided to which a needle can be attached for dose delivery and subsequently removed and discarded.
- a cover (not shown) may be provided to fit over the lower portion of the case 2 to assist in protect the device from the ingress of particles and fluid.
- Figure 2 shows the medicament delivery device 1 with the cartridge holder and door 7 in an open position for receiving a replacement medicament cartridge 9.
- Figure 3 shows the cartridge holder and door 7 in more detail, with the cartridge 9 seated therein.
- the holder 7 is pivotally fixed to the case 2 by an attachment 11 so that the holder 7 can move between an open position (see Figure 2 ) and a closed position (see Figure 1 ).
- An arm 13 extends into the case 2 and has a stop 15 to limit the outward extent of the door/holder 7 in the direction of arrow B.
- the stop 15 may also engage a latch switch or sensor 16, as shown in figure 6 , which is provided for sensing when the holder 7 moves from an open or a closed position.
- An actuator/lever 17 is provided for sensing the presence of the cartridge 9 and closure of the holder 7 within the case 2.
- Figure 4 is a sectional view taken along line A-A of Figure 3 and shows the cartridge 9 and the actuator/lever 17.
- the lever 17 forms part of a contact switch 19 that has a displaceable contact 21.
- This displaceable contact 21 is moved to change the state of the switch 19 when the cartridge is received in the holder 7.
- the lever 17, contact switch 19 and displaceable contact 21 together form a cartridge sensor.
- FIG. 5 is a perspective view of a telescopic piston rod assembly 23 that comprises slidable components 25 and 27 which telescope within a housing 29.
- the assembly 23 is provided with a dome switch 31 at the end thereof that contacts a bung 20 of the cartridge 9.
- the dome switch 31 is connected to a flexible PCB element 33 that extends within the components 25 and 27.
- the element 33 emerges from the other end thereof, through the housing 29 to terminate at a contact 35.
- the contact 35 is coupled to a control means (not shown) that is operative for controlling the device, including the drive of the piston rod.
- Figure 6 is a transparent view of the medicament delivery device of figure 2 and shows the approximate location of the latch switch or sensor 16 and the stop 15 within the device. Although shown as a contact switch, it may be appreciated that the latch switch or sensor may alternatively be a mechanical latch or any other switch or sensor known in the art.
- the operation of the medicament delivery device 1 is as follows.
- the latch sensor 16 is provided for sensing when the holder 7 moves from an open or closed position and the bung sensor 31 is operative for sensing when the piston rod 25, 27 is in contact with the bung 20.
- the control means is operative for advancing drive of the piston rod 25, 27 towards the bung 20 provided that the latch sensor 16 senses that the holder 7 has moved to a closed position.
- the control means is operative for advancing the drive of the piston rod 25, 27 until the bung sensor 31 senses that the piston rod is in contact with the bung 20.
- a cartridge sensor 17, 19, 21 is provided for sensing the presence of a medicament cartridge 9 in the holder 7.
- the control means is operative for advancing the drive of the piston rod 25, 27 when the cartridge sensor 17, 19, 21 senses the presence of the medicament cartridge and the latch sensor 16 senses that the holder 7 has moved from an open position to a closed position.
- the cartridge sensor 17, 19, 21 may also be beneficial for the cartridge sensor 17, 19, 21 to only be operative after the latch sensor 16 detects whether the holder 7 has been opened or closed. While the holder is not in a closed position, it is not necessary to monitor the cartridge sensor. This may increase battery life of the device.
- the holder 7 in order to load a medicament cartridge 9 into the device 1, the holder 7 (without a cartridge) may be opened to the position shown in figure 2 .
- the movement of the holder 7 from the closed position to the open position is detected by the latch sensor 16.
- the signal from the latch sensor 16 prompts the control means to watch the cartridge sensor 17, 19, 21 to determine if a medicament cartridge 9 is present. In the present case, no cartridge is present, so no signal is detected. Therefore, the control means does not advance the drive of the piston rod 25, 27. This also aids battery life.
- a medicament cartridge 9 may then be placed into the holder 7 and the holder closed.
- the latch switch 16 detects the movement of the holder, prompting the control means to watch the cartridge sensor 17, 19, 21.
- the displaceable contact 21 is in contact with the switch 19, indicating the presence of a medicament cartridge.
- the control means is operative for advancing the drive of the piston rod 25,27.
- the control means is operative to stop further advancement of the piston rod 25, 27: a) when the bung sensor 31 senses that the piston rod is in contact with the bung 20; or b) when the cartridge 9 has moved to a seated position within the holder (see Figure 3 ) after initial contact between the piston rod and the bung. In this case, the force needed to actuate the bung sensor 31 is greater than the sliding friction between the cartridge 9 and the holder 7.
- the holder 7 may include a door of the medicament delivery device 1.
- the control means may be operative for advancing the piston rod drive when the cartridge sensor 17, 19, 21 senses that the medicament cartridge 9 is in a predetermined (i.e. 'correct' or 'seated') position relative to the holder to deliver a dose of medicament.
- the latch sensor 16 and the bung sensor 31 may each generate sensor signals that are combined so that the combined signal sent to the control means indicates that the medicament cartridge 9 or holder 7 is present and/or in the correct position when the piston rod 25, 27 contacts the cartridge bung 20.
- the control means is operative to backwind the piston rod 25, 27 by a predetermined amount when the bung sensor 31 senses that the piston rod is in contact with the bung 20.
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicinal Preparation (AREA)
Claims (8)
- Dispositif (1) d'administration de médicament destiné à administrer un médicament à un patient, dans lequel le dispositif d'administration de médicament comporte : un boîtier (15) ; un support (7) à l'intérieur du boîtier destiné à recevoir une cartouche (9) de médicament ; une tige (25, 27) de piston destinée à entraîner une bonde (20) de la cartouche de médicament ; un mécanisme d'entraînement comprenant un moteur destiné à fournir un entraînement de sortie à la tige de piston pour administrer le médicament ; un moyen de commande destiné à commander le fonctionnement du dispositif ; un capteur (31) de bonde étant fourni pour capter le moment où la tige de piston est en contact avec la bonde ;
caractérisé en ce que : un capteur (16) de verrou est fourni pour détecter la position du support au fur et à mesure que le support se déplace d'une position ouverte à une position fermée ou d'une position fermée à une position ouverte, et
un capteur (17, 19, 21) de cartouche est fourni pour détecter la présence d'une cartouche de médicament dans le support ;
dans lequel le moyen de commande permet de faire avancer l'entraînement de la tige de piston vers la bonde lorsque le capteur (16) de verrou détecte que le support (7) est dans la position fermée et le capteur (17, 19, 21) de cartouche détecte la présence d'une cartouche (9) de médicament. - Dispositif (1) d'administration de médicament selon la revendication 1, dans lequel le moyen de commande permet de faire avancer l'entraînement de la tige (25, 27) de piston jusqu'à ce que le capteur (31) de bonde détecte que la tige de piston est en contact avec la bonde.
- Dispositif (1) d'administration de médicament selon la revendication 1 ou la revendication 2, dans lequel le moyen de commande surveille seulement l'état du capteur (17, 19, 21) de cartouche une fois que le capteur (16) de verrou a été activé.
- Dispositif (1) d'administration de médicament selon l'une quelconque des revendications précédentes, dans lequel le moyen (18) de commande permet de remonter la tige (25, 27) de piston en arrière d'une quantité prédéterminée lorsque le capteur (31) de bonde détecte que la tige de piston est en contact avec la bonde (20).
- Dispositif (1) d'administration de médicament selon l'une quelconque des revendications précédentes, dans lequel le moyen de commande permet d'arrêter tout mouvement supplémentaire d'avance de la tige (25, 27) de piston : a) lorsque le capteur (31) de bonde détecte que la tige de piston est en contact avec la bonde (20) ; ou b) lorsque la cartouche (9) s'est déplacée à une position d'assise à l'intérieur du boîtier (15) après un contact initial entre la tige de piston et la bonde.
- Dispositif (1) d'administration de médicament selon l'une quelconque des revendications précédentes, dans lequel le capteur (16) de verrou et le capteur (31) de bonde produisent chacun des signaux de capteurs qui sont conjugués de sorte que le signal conjugué envoyé au moyen de commande indique que la cartouche (9) est présente et/ou dans la position correcte lorsque la tige (25, 27) de piston vient en contact avec la bonde (20) de cartouche.
- Dispositif (1) d'administration de médicament selon l'une quelconque des revendications précédentes, dans lequel le boîtier (15) comprend un réceptacle destiné à une cartouche de médicament remplaçable par l'utilisateur.
- Auto-injecteur comprenant un dispositif (1) d'administration de médicament selon l'une quelconque des revendications précédentes.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10702138.8A EP2393533B1 (fr) | 2009-02-05 | 2010-02-03 | Dispositifs d'administration de médicament |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09001576 | 2009-02-05 | ||
PCT/EP2010/051272 WO2010089310A1 (fr) | 2009-02-05 | 2010-02-03 | Dispositifs d'administration de médicament |
EP10702138.8A EP2393533B1 (fr) | 2009-02-05 | 2010-02-03 | Dispositifs d'administration de médicament |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2393533A1 EP2393533A1 (fr) | 2011-12-14 |
EP2393533B1 true EP2393533B1 (fr) | 2015-03-25 |
Family
ID=40795045
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10702138.8A Active EP2393533B1 (fr) | 2009-02-05 | 2010-02-03 | Dispositifs d'administration de médicament |
Country Status (13)
Country | Link |
---|---|
US (2) | US9107996B2 (fr) |
EP (1) | EP2393533B1 (fr) |
JP (1) | JP5818692B2 (fr) |
CN (1) | CN102307605B (fr) |
AR (1) | AR075233A1 (fr) |
AU (1) | AU2010210160B2 (fr) |
BR (1) | BRPI1007894A8 (fr) |
CA (1) | CA2750465A1 (fr) |
DK (1) | DK2393533T3 (fr) |
HK (1) | HK1164759A1 (fr) |
IL (1) | IL214379A (fr) |
TW (1) | TWI519331B (fr) |
WO (1) | WO2010089310A1 (fr) |
Families Citing this family (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2475573C (fr) | 2002-02-11 | 2013-03-26 | Antares Pharma, Inc. | Injecteur intradermique |
ES2908027T3 (es) | 2005-01-24 | 2022-04-27 | Antares Pharma Inc | Un inyector con jeringa precargada |
US9022980B2 (en) | 2005-02-01 | 2015-05-05 | Kaleo, Inc. | Medical injector simulation device |
CA2976873C (fr) | 2005-02-01 | 2020-04-07 | Kaleo, Inc. | Dispositifs, systemes et procedes pour administrer un medicament |
US8361026B2 (en) | 2005-02-01 | 2013-01-29 | Intelliject, Inc. | Apparatus and methods for self-administration of vaccines and other medicaments |
US8206360B2 (en) | 2005-02-01 | 2012-06-26 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
US8231573B2 (en) | 2005-02-01 | 2012-07-31 | Intelliject, Inc. | Medicament delivery device having an electronic circuit system |
US8956291B2 (en) | 2005-02-22 | 2015-02-17 | Admetsys Corporation | Balanced physiological monitoring and treatment system |
WO2007131013A1 (fr) | 2006-05-03 | 2007-11-15 | Antares Pharma, Inc. | Injecteur de reconstitution à deux étages |
WO2007131025A1 (fr) | 2006-05-03 | 2007-11-15 | Antares Pharma, Inc. | Injecteur à dosage réglable |
WO2008091838A2 (fr) | 2007-01-22 | 2008-07-31 | Intelliject, Inc. | Injecteur médical équipé d'un système de détection et de surveillance de l'observance |
US20090093793A1 (en) | 2007-10-02 | 2009-04-09 | Yossi Gross | External drug pump |
US8814834B2 (en) | 2008-03-10 | 2014-08-26 | Antares Pharma, Inc. | Injector safety device |
USD994111S1 (en) | 2008-05-12 | 2023-08-01 | Kaleo, Inc. | Medicament delivery device cover |
WO2010011805A1 (fr) * | 2008-07-24 | 2010-01-28 | Admetsys Corporation | Dispositif et procédé pour échantillonner et mesurer automatiquement des substances sanguines à analyser |
AU2009279719B2 (en) | 2008-08-05 | 2015-07-23 | Antares Pharma, Inc. | Multiple dosage injector |
US10071198B2 (en) | 2012-11-02 | 2018-09-11 | West Pharma. Servicees IL, Ltd. | Adhesive structure for medical device |
USD810278S1 (en) | 2009-09-15 | 2018-02-13 | Medimop Medical Projects Ltd. | Injector device |
EP2482870B1 (fr) | 2009-09-29 | 2017-12-27 | Admetsys Corporation | Système et procédé permettant de différencier des récipients dans l'administration de médicaments |
US8348898B2 (en) * | 2010-01-19 | 2013-01-08 | Medimop Medical Projects Ltd. | Automatic needle for drug pump |
CA2801041A1 (fr) | 2010-06-07 | 2011-12-15 | Sanofi-Aventis Deutschland Gmbh | Dispositif d'administration de medicaments dote d'une source lumineuse |
EP2714146B1 (fr) | 2011-05-25 | 2018-03-07 | Sanofi-Aventis Deutschland GmbH | Dispositif d'administration de médicaments avec détecteur de cartouche et détecteur de fermeture du compartiment de cartouche et procédé de commande du dispositif |
US9220660B2 (en) | 2011-07-15 | 2015-12-29 | Antares Pharma, Inc. | Liquid-transfer adapter beveled spike |
US8496619B2 (en) | 2011-07-15 | 2013-07-30 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
EP4327849A3 (fr) | 2012-03-06 | 2024-04-24 | Antares Pharma, Inc. | Ampoule-seringue à caractéristique de force de rupture |
US9072827B2 (en) | 2012-03-26 | 2015-07-07 | Medimop Medical Projects Ltd. | Fail safe point protector for needle safety flap |
JP6457383B2 (ja) | 2012-04-06 | 2019-01-23 | アンタレス・ファーマ・インコーポレーテッド | テストステロン組成物の針支援式ジェット注入投与 |
US9364611B2 (en) | 2012-05-07 | 2016-06-14 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
JP6429776B2 (ja) * | 2012-08-20 | 2018-11-28 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 薬物送達デバイスおよびピストンロッドとカートリッジ栓との間の接触を電気的に検出する方法 |
WO2014029681A2 (fr) * | 2012-08-20 | 2014-02-27 | Sanofi-Aventis Deutschland Gmbh | Dispositif d'administration de médicament et procédé de détection d'un contact |
IL221634A0 (en) | 2012-08-26 | 2012-12-31 | Medimop Medical Projects Ltd | Universal drug vial adapter |
EP2932993B1 (fr) * | 2012-12-13 | 2017-03-29 | Panasonic Healthcare Holdings Co., Ltd. | Dispositif d'injection de médicament |
AU2013370241B2 (en) | 2012-12-27 | 2018-02-15 | Kaleo, Inc. | Devices, systems and methods for locating and interacting with medicament delivery systems |
DK3659647T3 (da) | 2013-02-11 | 2024-04-22 | Antares Pharma Inc | Nålestøttet jetinjektionsindretning med reduceret udløserkraft |
JP6030803B2 (ja) | 2013-03-11 | 2016-11-24 | アンタレス・ファーマ・インコーポレーテッド | ピニオンシステムを有する用量注射器 |
JP2016527038A (ja) * | 2013-08-05 | 2016-09-08 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 装置のカバー付勢手段 |
JP3205560U (ja) | 2013-08-07 | 2016-08-04 | メディモップ・メディカル・プロジェクツ・リミテッド | 点滴液容器とともに使用するための液体移送デバイス |
PL3038674T3 (pl) * | 2013-08-29 | 2020-07-13 | Shl Medical Ag | Urządzenie do dostarczania leku |
EP3166665A1 (fr) * | 2014-07-09 | 2017-05-17 | Novo Nordisk A/S | Dispositif d'administration de médicament motorisé |
US9517307B2 (en) | 2014-07-18 | 2016-12-13 | Kaleo, Inc. | Devices and methods for delivering opioid antagonists including formulations for naloxone |
US10971260B2 (en) | 2014-09-14 | 2021-04-06 | Becton, Dickinson And Company | System and method for capturing dose information |
US10704944B2 (en) | 2014-09-14 | 2020-07-07 | Becton, Dickinson And Company | System and method for capturing dose information |
USRE49515E1 (en) | 2014-11-20 | 2023-05-02 | Shl Medical Ag | Medicament delivery device |
JP6358724B2 (ja) | 2015-01-05 | 2018-07-18 | ウエスト・ファーマ.サービシーズ・イスラエル,リミテッド | 正確な使用を確保するための簡易着脱式薬瓶アダプタを有するデュアルバイアルアダプタアセンブリ |
WO2016115372A1 (fr) | 2015-01-16 | 2016-07-21 | Becton, Dickinson And Company | Module intelligent pour dispositifs d'injection automatique |
IL295010A (en) | 2015-03-10 | 2022-09-01 | Regeneron Pharma | System and method of piercing without contamination |
EP3302652B1 (fr) | 2015-06-04 | 2023-09-06 | Medimop Medical Projects Ltd. | Mode d'insertion de cartouche pour dispositif d'administration de médicaments |
BR112018000062B1 (pt) | 2015-07-16 | 2022-05-03 | Medimop Medical Projects Ltd | Dispositivo de transferência de fármaco líquido para encaixe telescópico flexível seguro em frasco de injeção |
US10576207B2 (en) | 2015-10-09 | 2020-03-03 | West Pharma. Services IL, Ltd. | Angled syringe patch injector |
JP7044708B2 (ja) | 2015-10-09 | 2022-03-30 | ウェスト ファーマ サービシーズ イスラエル リミテッド | カスタマイズシリンジの充填方法 |
CN108366905A (zh) | 2015-11-25 | 2018-08-03 | 西部制药服务以色列有限公司 | 包括具有自动密封的入口阀的药瓶转接器的双瓶转接器组件 |
DE102015121409A1 (de) * | 2015-12-09 | 2017-06-14 | Emperra Gmbh E-Health Technologies | Injektionsvorrichtung zur Injektion dosierter Mengen eines flüssigen Therapeutikums |
HUE060792T2 (hu) * | 2015-12-30 | 2023-04-28 | Ascendis Pharma As | Önmûködõ fecskendõ |
EP3397320A1 (fr) | 2015-12-30 | 2018-11-07 | Ascendis Pharma A/S | Injecteur automatique avec sécurité pour chargeur |
LT3397324T (lt) | 2015-12-30 | 2022-10-25 | Ascendis Pharma A/S | Automatinis injektorius su kasečių laikymo sistema |
US11179524B2 (en) | 2015-12-30 | 2021-11-23 | Ascendis Pharma A/S | Auto injector with detection of used cartridge and associated method |
JP7068184B2 (ja) | 2015-12-30 | 2022-05-16 | アセンディス ファーマ エー/エス | 調整可能な空気排出機構を備える自動注射器 |
EP3405229A1 (fr) | 2016-01-21 | 2018-11-28 | West Pharma. Services Il, Ltd. | Mécanisme d'introduction et de rétraction d'aiguille |
JP6885960B2 (ja) | 2016-01-21 | 2021-06-16 | ウェスト ファーマ サービシーズ イスラエル リミテッド | 視覚的インジケータを有する薬剤デリバリデバイス |
JP6513297B2 (ja) | 2016-01-21 | 2019-05-22 | ウェスト ファーマ サービシーズ イスラエル リミテッド | 自動注射器、受け入れフレーム及び自動注射器におけるカートリッジの接続方法 |
CN105521548B (zh) * | 2016-02-02 | 2018-08-10 | 西安金六棠生物科技有限公司 | 一种多功能药物推送器 |
EP3207952A1 (fr) * | 2016-02-16 | 2017-08-23 | Carebay Europe Ltd. | Mécanisme de retour automatique et dispositif d'administration de médicament avec capacité de rétroaction d'utilisateur |
CN108697860B (zh) | 2016-02-24 | 2020-12-01 | 艾斯曲尔医疗公司 | 用于药剂输送装置的安全机构和包括该安全机构的药剂输送装置 |
US11141533B2 (en) | 2016-02-24 | 2021-10-12 | Shl Medical Ag | Safety mechanism for a medicament delivery device and a medicament delivery device comprising the same |
EP3420549B1 (fr) | 2016-02-25 | 2022-11-02 | SHL Medical AG | Dispositif d'apprentissage d'injection automatique |
AU2017222360B2 (en) * | 2016-02-26 | 2019-08-08 | Eli Lilly And Company | Reusable medication delivery device with remaining medication determination capability |
WO2017161076A1 (fr) | 2016-03-16 | 2017-09-21 | Medimop Medical Projects Ltd. | Ensemble de vis télescopique étagé ayant différents indicateurs visuels |
US11318256B2 (en) | 2016-04-16 | 2022-05-03 | Shl Medical Ag | Injection device |
IL245803A0 (en) | 2016-05-24 | 2016-08-31 | West Pharma Services Il Ltd | Devices with two vial adapters include an aerated drug vial adapter and an aerated liquid vial adapter |
IL245800A0 (en) | 2016-05-24 | 2016-08-31 | West Pharma Services Il Ltd | A device with two vial adapters includes two identical vial adapters |
EP3463526A1 (fr) | 2016-06-02 | 2019-04-10 | West Pharma. Services Il, Ltd. | Rétraction de l'aiguille en trois positions |
IL246073A0 (en) | 2016-06-06 | 2016-08-31 | West Pharma Services Il Ltd | A fluid transport device for use with a slide-driven piston medicine pump cartridge |
CN113577438B (zh) | 2016-08-01 | 2023-05-23 | 西医药服务以色列有限公司 | 部分门关闭防止弹簧 |
US11338090B2 (en) | 2016-08-01 | 2022-05-24 | West Pharma. Services IL, Ltd. | Anti-rotation cartridge pin |
IL247376A0 (en) | 2016-08-21 | 2016-12-29 | Medimop Medical Projects Ltd | Injector assembly |
IL249408A0 (en) | 2016-12-06 | 2017-03-30 | Medimop Medical Projects Ltd | A device for transporting fluids for use with an infusion fluid container and a hand tool similar to a plunger to release a vial from it |
EP3570906A4 (fr) | 2017-01-17 | 2020-10-21 | Kaleo, Inc. | Dispositifs d'administration de médicament à connectivité sans fil et à détection d'événement |
IL251458A0 (en) | 2017-03-29 | 2017-06-29 | Medimop Medical Projects Ltd | Liquid drug delivery devices are user-operated for use in pre-prepared liquid drug delivery assemblies (rtu) |
AU2018260992B9 (en) | 2017-05-05 | 2024-02-15 | Regeneron Pharmaceuticals, Inc. | Auto-injector |
US11331429B2 (en) * | 2017-05-05 | 2022-05-17 | Sanofi | Cartridge for dosage sensing |
JP7132247B2 (ja) * | 2017-05-05 | 2022-09-06 | サノフイ | カートリッジのストッパへの電子機器の一体化 |
JP7146816B2 (ja) * | 2017-05-23 | 2022-10-04 | アセンディス ファーマ エー/エス | 可変プランジャ力を備えた自動注射器 |
US11819666B2 (en) | 2017-05-30 | 2023-11-21 | West Pharma. Services IL, Ltd. | Modular drive train for wearable injector |
KR102617190B1 (ko) | 2017-06-29 | 2023-12-22 | 아센디스 파마 에이에스 | 재구성 처리 지원을 갖춘 자동 인젝터 |
TWI653068B (zh) * | 2017-07-31 | 2019-03-11 | 鐸康股份有限公司 | Drug delivery device |
EP3664864B1 (fr) * | 2017-08-10 | 2022-06-29 | West Pharma. Services Il, Ltd. | Mécanisme de perforation de cartouche retardé par injecteur |
US11511042B2 (en) * | 2017-08-10 | 2022-11-29 | West Pharma. Services IL, Ltd. | Injector power-up mechanism |
WO2019032395A1 (fr) | 2017-08-10 | 2019-02-14 | West Pharma Services, Il, Ltd | Mécanisme de verrouillage de porte de cartouche d'injecteur |
IL254802A0 (en) | 2017-09-29 | 2017-12-31 | Medimop Medical Projects Ltd | A device with two vial adapters includes two identical perforated vial adapters |
US11857767B2 (en) | 2017-12-22 | 2024-01-02 | West Pharma. Services IL, Ltd. | Injector usable with different dimension cartridges |
JP1630477S (fr) | 2018-07-06 | 2019-05-07 | ||
US11929160B2 (en) | 2018-07-16 | 2024-03-12 | Kaleo, Inc. | Medicament delivery devices with wireless connectivity and compliance detection |
WO2020081897A1 (fr) * | 2018-10-19 | 2020-04-23 | West Pharmaceutical Services, Inc. | Ensemble piston électronique |
USD923812S1 (en) | 2019-01-16 | 2021-06-29 | West Pharma. Services IL, Ltd. | Medication mixing apparatus |
JP1648075S (fr) | 2019-01-17 | 2019-12-16 | ||
JP7101900B2 (ja) | 2019-01-31 | 2022-07-15 | ウェスト・ファーマ・サービシーズ・アイエル・リミテッド | 液体移送装置 |
US11484470B2 (en) | 2019-04-30 | 2022-11-01 | West Pharma. Services IL, Ltd. | Liquid transfer device with dual lumen IV spike |
USD956958S1 (en) | 2020-07-13 | 2022-07-05 | West Pharma. Services IL, Ltd. | Liquid transfer device |
USD1007676S1 (en) | 2021-11-16 | 2023-12-12 | Regeneron Pharmaceuticals, Inc. | Wearable autoinjector |
WO2024094440A1 (fr) * | 2022-11-04 | 2024-05-10 | Shl Medical Ag | Unité d'entraînement réutilisable d'un dispositif d'administration de médicament |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6241704B1 (en) * | 1901-11-22 | 2001-06-05 | Sims Deltec, Inc. | Drug pump systems and methods |
US5437635A (en) * | 1992-05-06 | 1995-08-01 | Mcgaw, Inc. | Tube flow limiter, safety flow clip, and tube pincher mechanism |
KR100469207B1 (ko) | 1995-10-20 | 2005-03-16 | 화이자 헬스 에이비 | 전자식주입조정장치 |
KR100383477B1 (ko) * | 1996-07-01 | 2003-09-22 | 파마시아 에이비 | 주입장치및이의작동방법 |
US6979309B2 (en) * | 1997-02-14 | 2005-12-27 | Nxstage Medical Inc. | Systems and methods for performing blood processing and/or fluid exchange procedures |
DE69913344T2 (de) * | 1998-06-15 | 2004-10-14 | Medrad, Inc. | Kodierung von spritzeninformation |
US6544229B1 (en) * | 2000-05-01 | 2003-04-08 | Baxter International Inc | Linearly motile infusion pump |
IL156245A0 (en) * | 2000-12-22 | 2004-01-04 | Dca Design Int Ltd | Drive mechanism for an injection device |
AU2003233504A1 (en) * | 2002-05-24 | 2003-12-12 | Eli Lilly And Company | Medication injecting apparatus with fluid container piston-engaging drive member having internal hollow for accommodating drive member shifting mechanism |
DE10330094B4 (de) * | 2003-07-03 | 2008-04-17 | Disetronic Licensing Ag | Vorrichtung zur Verabreichung eines flüssigen Produkts |
ES2555125T3 (es) * | 2004-02-18 | 2015-12-29 | Ares Trading S.A. | Dispositivo manual de inyección controlada electrónicamente para inyectar medicamentos líquidos |
JP4382115B2 (ja) * | 2007-07-10 | 2009-12-09 | 株式会社アイカムス・ラボ | カートリッジ式液体注入器 |
US8998840B2 (en) * | 2009-12-30 | 2015-04-07 | Medtronic Minimed, Inc. | Connection and alignment systems and methods |
-
2010
- 2010-02-03 EP EP10702138.8A patent/EP2393533B1/fr active Active
- 2010-02-03 JP JP2011548670A patent/JP5818692B2/ja active Active
- 2010-02-03 WO PCT/EP2010/051272 patent/WO2010089310A1/fr active Application Filing
- 2010-02-03 DK DK10702138.8T patent/DK2393533T3/en active
- 2010-02-03 CA CA2750465A patent/CA2750465A1/fr not_active Abandoned
- 2010-02-03 AU AU2010210160A patent/AU2010210160B2/en not_active Ceased
- 2010-02-03 CN CN201080006707.3A patent/CN102307605B/zh active Active
- 2010-02-03 US US13/145,835 patent/US9107996B2/en active Active
- 2010-02-03 TW TW099103101A patent/TWI519331B/zh not_active IP Right Cessation
- 2010-02-03 BR BRPI1007894A patent/BRPI1007894A8/pt not_active IP Right Cessation
- 2010-02-03 AR ARP100100296A patent/AR075233A1/es unknown
-
2011
- 2011-08-01 IL IL214379A patent/IL214379A/en not_active IP Right Cessation
-
2012
- 2012-06-04 HK HK12105408.1A patent/HK1164759A1/xx unknown
-
2015
- 2015-07-07 US US14/793,076 patent/US9610407B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP5818692B2 (ja) | 2015-11-18 |
DK2393533T3 (en) | 2015-06-29 |
TWI519331B (zh) | 2016-02-01 |
AR075233A1 (es) | 2011-03-16 |
US20150306316A1 (en) | 2015-10-29 |
BRPI1007894A8 (pt) | 2016-09-13 |
CA2750465A1 (fr) | 2010-08-12 |
US9107996B2 (en) | 2015-08-18 |
US9610407B2 (en) | 2017-04-04 |
TW201029699A (en) | 2010-08-16 |
EP2393533A1 (fr) | 2011-12-14 |
AU2010210160B2 (en) | 2014-09-04 |
JP2012516737A (ja) | 2012-07-26 |
AU2010210160A1 (en) | 2011-08-25 |
CN102307605A (zh) | 2012-01-04 |
WO2010089310A1 (fr) | 2010-08-12 |
HK1164759A1 (en) | 2012-09-28 |
BRPI1007894A2 (pt) | 2016-02-16 |
IL214379A (en) | 2014-11-30 |
CN102307605B (zh) | 2014-09-03 |
IL214379A0 (en) | 2011-09-27 |
US20120071819A1 (en) | 2012-03-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2393533B1 (fr) | Dispositifs d'administration de médicament | |
EP2414004B1 (fr) | Améliorations concernant des dispositifs d'administration de médicament | |
EP2477681B1 (fr) | Unité de verrouillage et de contrôle à intégrer dans un appareil médical | |
EP2393534B1 (fr) | Dispositifs d'administration de médicaments | |
JP6526006B2 (ja) | 充電安全機能を備えたモータ駆動式薬物送達デバイス | |
US20170157340A1 (en) | Drug Delivery Device with Indicator Guidance | |
EP3193983A1 (fr) | Dispositif d'administration de médicament avec élément distal de dispositif d'entraînement de piston |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20110905 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR |
|
DAX | Request for extension of the european patent (deleted) | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1164759 Country of ref document: HK |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
INTG | Intention to grant announced |
Effective date: 20140905 |
|
GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: FG4D |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: EP |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: FG4D |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R096 Ref document number: 602010023366 Country of ref document: DE Effective date: 20150507 |
|
REG | Reference to a national code |
Ref country code: AT Ref legal event code: REF Ref document number: 717502 Country of ref document: AT Kind code of ref document: T Effective date: 20150515 |
|
REG | Reference to a national code |
Ref country code: DK Ref legal event code: T3 Effective date: 20150625 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: FI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150325 Ref country code: NO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150625 Ref country code: SE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150325 Ref country code: LT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150325 Ref country code: HR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150325 |
|
REG | Reference to a national code |
Ref country code: AT Ref legal event code: MK05 Ref document number: 717502 Country of ref document: AT Kind code of ref document: T Effective date: 20150325 |
|
REG | Reference to a national code |
Ref country code: LT Ref legal event code: MG4D |
|
REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1164759 Country of ref document: HK |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LV Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150325 Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150626 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: NL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150325 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150325 Ref country code: ES Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150325 Ref country code: CZ Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150325 Ref country code: EE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150325 Ref country code: RO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150325 Ref country code: PT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150727 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: PL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150325 Ref country code: IS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150725 Ref country code: AT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150325 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R097 Ref document number: 602010023366 Country of ref document: DE |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 7 |
|
PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
26N | No opposition filed |
Effective date: 20160105 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150325 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: BE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20160229 Ref country code: SI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150325 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: BE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150325 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LU Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160203 Ref country code: MC Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150325 |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: MM4A |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 8 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20160203 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150325 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 9 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SM Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150325 Ref country code: HU Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO Effective date: 20100203 Ref country code: CY Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150325 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160229 Ref country code: MK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150325 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: BG Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150325 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: TR Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20200203 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: GB Payment date: 20231214 Year of fee payment: 15 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: FR Payment date: 20231212 Year of fee payment: 15 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: DE Payment date: 20231212 Year of fee payment: 15 Ref country code: CH Payment date: 20240301 Year of fee payment: 15 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: DK Payment date: 20240214 Year of fee payment: 15 |