EP2393467A1 - Procédé pour produire un empilement de pochettes servant à conserver et à mettre à disposition des médicaments sous forme stratifiée, modèle de pochette pour produire ledit empilement et utilisation dudit modèle - Google Patents

Procédé pour produire un empilement de pochettes servant à conserver et à mettre à disposition des médicaments sous forme stratifiée, modèle de pochette pour produire ledit empilement et utilisation dudit modèle

Info

Publication number
EP2393467A1
EP2393467A1 EP10702625A EP10702625A EP2393467A1 EP 2393467 A1 EP2393467 A1 EP 2393467A1 EP 10702625 A EP10702625 A EP 10702625A EP 10702625 A EP10702625 A EP 10702625A EP 2393467 A1 EP2393467 A1 EP 2393467A1
Authority
EP
European Patent Office
Prior art keywords
drug
stack
pockets
medicament
pocket
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10702625A
Other languages
German (de)
English (en)
Inventor
Kathrin Reichardt
Sven Filler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Intellectual Property GmbH
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE200910008028 external-priority patent/DE102009008028A1/de
Priority claimed from DE102009008026A external-priority patent/DE102009008026A1/de
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of EP2393467A1 publication Critical patent/EP2393467A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/078—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of wafers or cachets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B31—MAKING ARTICLES OF PAPER, CARDBOARD OR MATERIAL WORKED IN A MANNER ANALOGOUS TO PAPER; WORKING PAPER, CARDBOARD OR MATERIAL WORKED IN A MANNER ANALOGOUS TO PAPER
    • B31B—MAKING CONTAINERS OF PAPER, CARDBOARD OR MATERIAL WORKED IN A MANNER ANALOGOUS TO PAPER
    • B31B2160/00—Shape of flexible containers
    • B31B2160/10—Shape of flexible containers rectangular and flat, i.e. without structural provision for thickness of contents
    • B31B2160/102—Shape of flexible containers rectangular and flat, i.e. without structural provision for thickness of contents obtained from essentially rectangular sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B31—MAKING ARTICLES OF PAPER, CARDBOARD OR MATERIAL WORKED IN A MANNER ANALOGOUS TO PAPER; WORKING PAPER, CARDBOARD OR MATERIAL WORKED IN A MANNER ANALOGOUS TO PAPER
    • B31B—MAKING CONTAINERS OF PAPER, CARDBOARD OR MATERIAL WORKED IN A MANNER ANALOGOUS TO PAPER
    • B31B70/00—Making flexible containers, e.g. envelopes or bags
    • B31B70/74—Auxiliary operations
    • B31B70/92—Delivering
    • B31B70/98—Delivering in stacks or bundles
    • B31B70/984—Stacking bags on wicket pins

Definitions

  • the present invention relates to a method of making a stack of drug bags for storing and providing drug wafers, including using a drug pocket template, and uses for making a stack and making a device for storing and providing drug wafers.
  • Pharmaceutical wafers contain the drugs in layer form.
  • the pharmaceutical wafers may in particular contain hormonal drugs, especially drugs for contraception or hormone replacement therapy.
  • compositions are sheet-like devices containing pharmaceutically active agents contained in a drug carrier.
  • the active substances in the wafers can be administered, for example, transmucosally, ie via the oral mucosa, by placing the wafers on or under the tongue, whereby the active substance carrier dissolves, thereby releasing the active substances.
  • the wafers are provided enclosed in foil pockets to protect them against mechanical and other environmental influences, such as moisture. According to DE 101 59 746 B4, these pockets can consist of at least one carrier foil and at least one cover foil, wherein at least the areal larger foil has two parallel side edges and between the carrier foil and the cover foil the foil- or sheet-like material (wafer) gas- and moistureproof is included.
  • Devices for storing and providing the drug wafers may contain foil bags stacked therein.
  • the drug wafers can also be modified from this, namely, by not necessarily consisting of a larger area film and a smaller area film, but for example from the same size films.
  • the described film pouches containing the drug wafers are simply combined to form a stack and introduced into the device.
  • the device described there for storing and loading providing the wafers comprises an at least single-divided housing, abut on the lateral inner sides of the side edges of the stacked film pockets, while on a front inside that edge of a carrier film is present, which projects beyond the edge of an associated cover sheet.
  • the stacked film bags are pressed by a spring against the upper inside of the housing.
  • the front upper portion of the housing has two slots for separately discharging the carrier film and the cover film, whereby the wafer can be provided with the carrier film or with the cover film.
  • the task of the spring is to hold together the remaining film pockets near the slots after removal of a foil bag and to position them for further removal.
  • a separating tool for separating the carrier film from the cover film is arranged, on which the uppermost carrier film rests with its region lying in front of the front edge of the cover film.
  • This device with its succession of pharmaceutical bags to be removed has the disadvantage that a (e) user in the use of the withdrawn drug bags for taking the drug wafers on the one hand has no control over whether a given period prescribed intake has already been or still must be done. Therefore, it can easily come to a double intake, or the user in general forgets to take the wafer.
  • this closed device can not see how many wafers he / she has already taken or how long the intake must continue.
  • a particular disadvantage of this device is moreover that the user can not recognize on the basis of the closed design whether the device contains all the medicament pockets necessary for the treatment at all. An opening of this compact built device is not provided and would destroy it.
  • indications on the second foil e.g. Weekdays, be upset.
  • a blister is provided with pockets arranged in a row for the tablets.
  • the pockets are
  • each zone is visually identifiable with one and only one calendar day of the calendar month. This allows each bag to be loaded from the front and the back with one and only one calendar be identified visually. Thus, removal of the tablets on a daily basis and compliance with user compliance can be facilitated.
  • EP 0 511 726 B1 describes an arrangement for receiving tablets in a field, comprising: a blister pack having a predetermined area in which a plurality of tablets configured in a selected field are located, a container for holding the blister pack and a Daily calendar that can be aligned with the field of tablets in the blister pack, with the daily calendar being slidable to position a selected start day on a first tablet in the field of tablets and with hands provided on the container and the blister pack having a locating score near the edge and in the vicinity of a first tablet, so that the first tablet to be removed is displayed.
  • DE 10 2005 032 015 A1 discloses a case for receiving a blister pack which has a first and a second half hinged thereto.
  • the first Etuihffy is designed as a pocket for receiving the blister pack and has an outer part and an inner visible part and first openings in the visible part and second openings in the outer part, wherein the first openings are aligned with the second openings, at least where the containers for the tablets are in the blister pack after picking up in the bag.
  • the second half of the case has a compartment for receiving a display of the days of the week and windows for displaying the days of the week in an inner visible area of the second half of the compartment in the area of the compartment, wherein the windows are arranged such that they correspond to the columns of the containers of a pocket Blister pack are assigned.
  • a first object is to find means by which the drug-containing drug pockets are prepared for a user to: (i) order the wafers in the order and at the prescribed rate; as a function of the time of taking safely removes or occupies the device.
  • the device must be capable of allowing the user (s) to control the prescription of drug wafers over a given period of time.
  • the device for storing and providing the drug wafers should also be suitable for everyday use and have the required mechanical stability. The drug wafers should also be stored safely.
  • Another object is to be able to produce such dosage forms with a virtually flawless production process easily and simply and thus inexpensively, so that the dosage form the / the user (in) ensures the safe and flawless receipt of the wafer.
  • a cost-effective production of the dosage form also requires that a variety of such dosage forms can be produced in a short time.
  • a further object of the present invention is to design the method for producing the stack so that a simple control over the completeness of the stack in terms of the number of drug pockets is already possible during the manufacturing process.
  • a faultless destacking is to be made possible, so that the stack contains neither too few nor too many drug pockets.
  • the aim is to reduce the costs by scrap and the costs of final inspection of the stacks produced or for quality assurance.
  • Yet another object of the present invention is to provide a drug pocket template and a method for making a stack of drug pockets for storing and providing drug wafers from the drug pocket template that can be used to create a stack that provides the user with in use, allows control over the drug wafers already taken.
  • the method according to the invention serves to produce a stack of medicament pockets serving for storage and provision of medicament wafers, wherein each medicament pocket has a marking in each case at one marking edge in one of a plurality of marking sections arranged next to one another on the marking edge.
  • a drug pocket for the drug wafers consists of a base sheet and a coversheet.
  • the cover sheet can be placed along one of the side edges of the cover
  • cover sheet extending preferably strip-shaped compound connected to the base or base film, for example, glued or welded, be, or vice versa.
  • the base or base film and the cover film can each have overlapping tabs on at least one side edge which are not connected to one another. This will result in a pulling apart and thus opening of the medicament
  • a drug wafer is preferably enclosed between the base sheet and the coversheet within a region formed by the compound, preferably in a hermetically and moisture-proof manner. Due to their structure or only in the area of the wafer, the film pockets can have a small elevation due to this condition.
  • the dispenser device for storing and providing the medicament wafer to be produced by the method according to the invention contains the medicament pockets with the medicament wafers in the form of a (pocket) stack. To enable a user to check whether a drug wafer has already been taken in a certain period of time, or
  • a mark is placed on each of the drug pockets such that markers applied to stacked drug pockets in the stack are each aligned with successive times and that in the stack, if appropriate, a drug pocket with a marker located at a first end of the marker edge follows a drug pocket with a marker located at a second end of the marker edge. This latter case applies when there are a number of drug pockets in the stack that
  • 5 is greater than the number of marker portions on each drug pocket, such that the sequence of consecutive markers in the marker portions in the stack repeats. Thus, the markers follow one another on stacked drug pockets, but if a drug pocket has a mark in the last marker portion, the subsequent drug pocket in the stack will become one
  • the marks arranged on the marking edge 5 are aligned according to the invention with time information after the stack has been received in the dispensing device for storage and provision of the wafer. This will allow the user to determine whether or not a wafer has been taken in a given period of time.
  • this stack must be produced flawlessly. Namely, if in the stack a single drug bag is missing or even a drug bag is duplicated so that consequently a tag in a particular tag section in the sequence of drug bags in the stack is missing or duplicated, the user will (in) misled, and it can lead to a misappropriation, ie the user forgets
  • the stack manufacturing process must proceed flawlessly so that stacks are produced in which the drug pockets with the markers are stacked on top of each other such that the markings of successive drug pockets in the stack are also in successive marker sections or i ⁇ optionally one Pharmaceutical bag with a marker located at a first end of the marker edge on a drug pocket with a located at a second end of the marker edge marker follows. In addition, it must be ensured that the stacks can be produced with high production efficiency, ie with a high cycle rate.
  • the stacking or stacking of drug pockets this means the juxtaposition of the drug pockets, i.
  • a stacked on a stack drug bag is placed on the stack.
  • the stack produced by the method according to the invention can be used in particular for storing and providing medicament wafers used for contraception or hormone replacement therapy.
  • a medicament pouch template is provided, from which the medicament pouches can be formed by singulation.
  • the provision of markings on one marking edge on the medicine bags ensures that the user can check whether or not a wafer has already been taken in a given period of use. This is done by checking that the label on the overhead medicine bag is aligned with a time field that corresponds to the current time period.
  • the production method comprises the following method steps:
  • a very efficient method of production is achieved, namely the fact that in the stacking of further medicament pockets in the further Manufacturing devices on the at least one first sub-stack, preferably at least one next first sub-stack in the first manufacturing device can be produced at the same time.
  • the partial stacks can be generated simultaneously. The same applies in the event that with the piled up of medicine bags on the at least one first partial stack in the second production device is not yet produced the at least one complete bag stack, but first at least a second partial stack is generated and still more medicine bags must be stacked on these at least a second partial stack.
  • pharmaceutical drugs are then stacked on the at least one second partial stack in a third production device.
  • the resulting at least one third partial stack or the resulting at least one complete pocket stack are likewise preferably produced simultaneously with the at least one first and the at least one second partial stack, etc.
  • each sub-stack can be checked separately, whether the sub-stack has been made flawless. This makes it possible to remove a faulty partial stack before the completion of a complete stack of bags from the production process. This ensures that additional medicine bags are no longer stacked on an already faulty partial stack. On the one hand, this increases the production capacity and reduces to the other.
  • each at least a second and third partial stack in a second and third manufacturing device by stacking additional drug pockets on each previously formed partial stack and at least one complete stack of drug pockets in a fourth manufacturing device are generated by stacking additional drug pockets on every third sub-stack.
  • the at least one first partial stack produced in the first production device and the further partial stacks generated in further production devices by stacking additional medicament pockets on the at least one first partial stack are generated simultaneously, ie the further stacking of the medicament pockets on the at least a first partial stack in the further production devices takes place simultaneously with the production of the at least one first partial stack in the first production device, whereby of course the at least one first partial stack must first be produced in the first manufacturing device before it is conveyed into the second manufacturing device, so that there more medicine bags under Formation of at least a second sub-stack or at least a complete stack of drug bags can be stacked.
  • the method comprises the following method steps:
  • the at least one first partial stack formed in method step a) in the first production device as well as further partial stacks formed in further production devices are formed of the bag stack stacked on top of one another such that drug stacks follow one another in succession, the tags being in successive marker sections, and optionally a drug pocket having a marker located at a first end of the marker edge on a drug pocket having a second end of the marker edge following mark follows.
  • the at least one first partial stack produced in the first production device and the further partial stacks generated in the further production devices are generated simultaneously, i. the respective successive stacking of the drug pockets to form the at least one first sub-stack, the at least one second sub-stack, the at least one third sub-stack, the at least one fourth sub-stack, etc. takes place simultaneously.
  • At least one partial stack is produced, which is then combined by stacking the respective (previously separately prepared) partial stacks to the at least one complete stack of drug pockets, also in this case, possibly defective partial stacks from the manufacturing process be discharged before the entire bag pile is formed.
  • This allows for a cost-effective production, because the amount of the Committee is minimized.
  • it also speeds up the manufacturing process because the drug pockets that would otherwise have been taken up in the faulty stack can thus be used to make faultless stacks.
  • At least two first part stacks are produced simultaneously by stacking the medicament pockets together, at least two second part stacks are produced simultaneously, at least two third part stacks are produced simultaneously, etc.
  • first embodiment variant of the invention with the exception of FIG first sub-stacks by stacking drug pockets each on already formed sub-stacks and in the second embodiment of the invention by respectively separate stacking of the drug pockets to form respective sub-stacks, wherein the first, second, third sub-stacks, etc. are then combined by stacking on each other.
  • six or twelve first partial stacks are produced at the same time by stacking the medicament pockets on one another. This may be in a suitable
  • IO device combined with six or twelve second sub-stacks. These sequences can be continued as desired, for example by transferring the six or twelve second partial stacks in the first variant of the invention into a third production device and there by simultaneously stacking further medicament pockets on the six or twelve second partial stacks! six or twelve third partial stacks or six or twelve complete stacks of pockets are generated
  • the simultaneous stacking of the two variants of the method is not only to be understood as meaning that the medicament pockets, while forming the respective part stacks in synchronism, i. as it were "in the same bar” or “synchronously", stacked on top of each other. Under the simultaneous stacking is rather to understand that the respective partial stacks are generated at about the same time.
  • the bag stacks can be done very fast in this way
  • ! 5 are produced.
  • synchronous stacking is preferred in this case.
  • a plurality of medicament pockets are simultaneously fed to the respective production device, and these medicament pockets, which are simultaneously supplied, are then stacked on one another in synchronism with the partial stacks.
  • the medicament pockets for producing the partial stacks are stacked in each case in a cassette.
  • at least one cassette is preferably provided, in which the medicament pockets are inserted and then stacked on one another.
  • NEN six or twelve cassettes may be provided, which are arranged for example in a row or in a carousel.
  • the cassettes can furthermore be movable, for example, in order to convey the partial stacks produced in the cassettes to a further production device, in which each partial stacks according to the second embodiment of the invention is combined with another partial stacks by placing the further partial stacks on the first partial stack is placed in the cassette.
  • the cassettes can also be moved in order to transport them to a second production IO device, in which further medicament pockets according to the first embodiment variant of the invention are stacked on the first part stack.
  • the first partial stack may be formed by seven drug pockets.
  • the second production device seven medicament pockets can then also be stacked on the first part stack.
  • the second 15 partial stack thus containing 14 medicine bags can be conveyed into a third production device, in which, for example, a further seven pharmaceutical bags are stacked on the second partial stack.
  • the third sub-stack which in the meantime contains 21 medicament pockets, can be conveyed into a fourth production apparatus, in which, for example, a further seven medicament pockets are stacked on the third sub-stack.
  • this method can be carried out with any number of drug pockets in each of the production devices and with any number of production devices. For example, it can be used to produce bags of 28 medicine bags.
  • the piles of bags typically hold 28 drug pockets.
  • the 28 drug pouches can be used in the same way - 28 for a single phase preparation - 28 same drug wafers or - for contraception in a biphasic preparation - 24 same drug wafers and 4 additional drug wafers with a placebo or other drug or even a biphasic drug 21 Drug wafers and seven other SO drug wafers with a placebo or other drug.
  • the drug pockets containing the wafers containing the placebo or other drug must be inserted at the beginning or end of the bag stack.
  • the medicament pockets are assembled into a stack containing the wafers containing the placebo or the other medicament or, at the end of the stacking process, stacked in a separate production device on the already produced partial stack.
  • the pocket stacks may, for example, for contraception also contain a different number of drug pockets than 28, namely, for example, 30 drug pockets.
  • ten drug bags each can be added to the already existing sub-stacks (or stacked to produce the first sub-stacks), or (four times) seven drug pockets and finally two drug pockets in another manufacturing device ,
  • the wafers in case of use for contraception, may also be used for a so-called flexible intake regimen in which the wafers are taken during a first flexible ingestion phase lasting at least 24 days and at most 120 days which is followed by the first flexible intake phase, for example, a four-day interruption phase.
  • the pocket stack may also comprise, for example, 28 or even 56 or even 84 or 112 or even 120 medicine bags or any other number.
  • the pattern for stacking the drug pockets according to the present invention in this case, in a corresponding manner, depends in each case on the number of drug pockets in the stack.
  • seven marking sections may be located at the marking edge of each drug pocket. These marker sections, wherein a marker is mounted in one of the marker sections of a drug pocket, may correspond, for example, to the days of the week.
  • the marker sections may be aligned with corresponding times on the device, such as weekday indications, such that a marker in a marker section on a drug pocket resting in the stack on top with a specific day of the week on the Device is aligned, for example, with "Mo" for Monday, indicating the user which day the wafer must be taken in this medicine bag, ie in the present case on Monday.
  • marking sections corresponding to three daily times (morning, noon, evening), or also a different number of marking sections may be provided, which corresponds to the respective requirements of the frequency of taking.
  • each case seven drug pockets can be stacked on each other to form at least one first sub-stack.
  • a further seven medicament pockets are then stacked onto the at least one first substack to form a second substack, in each case a further seven medicament pockets are stacked on the at least one second partial stack.
  • in the second embodiment of the invention in addition to the first sub-stacks second, third sub-stacks, etc. are generated, each containing seven drug pockets. The respective partial stacks are then stacked on top of each other.
  • the drug pockets in the sub-stack may preferably serve to take the wafers for one week, if one wafer per day is taken.
  • the stack is produced in four production devices, in each of which seven medicament pockets are stacked for each stack.
  • four partial stacks are produced and then combined by stacking medicament pockets on top of one another to form a complete stack. If the wafers are each taken once a day and there are seven drug bags each in a sub-stack, the stack comprises 28 wafers taken in 28 days.
  • the drug pockets are produced by singulation from a drug pocket template, for example from a sheet.
  • a drug pocket template for example from a sheet.
  • the sheet is preferably layered of different materials.
  • the drug pockets may preferably be formed from two laminates, between which the drug wafer is located.
  • the laminates may have the following sequence of layers: polyethylene / aluminum / polyethylene terephthalate, the polyethylene layers each bearing against the drug wafer and the polyterephthalate layers facing outward.
  • An arc is also a band, i. E. an elongated sheet, for example, on a roll (coil) is wound up.
  • a sheet is preferably brought to the individual production devices and placed under a separating device. There, the individual drug bags from the sheet are preferably separated simultaneously. Preferably, the separation material (drug pockets and separation residues) then becomes a collection site
  • the medicine bags are removed in succession, for example by means of robot arms.
  • the robotic arms may be equipped with special sensors to verify that each drug bag has been gripped, transported and placed in the cassettes.
  • the pharmaceutical bags are preferably separated from the sheet by punching. This is a cost effective and precise separation technique. Other separation techniques are also conceivable, for example cutting.
  • the sheet contains fields corresponding to the medicament pockets, each having a medicament wafer and each having a marking in respective marking sections at respective field edges in a matrix-like arrangement.
  • the drug wafers are hermetically sealed by welding.
  • on the sheet other than the markings imprints may be located, for example, allow the identification of the drug.
  • the arc preferably contains at least four and at most twelve rows of fields. For example, four, eight, ten or twelve rows of fields may be provided. Each row contains, for example, seven or fourteen fields.
  • fields whose markings are in successive marking sections follow one another in a respective row on the sheet.
  • the medicine bags can be removed from the sheet in the logical sequence in which they are also stacked on one another in the partial stack.
  • Multiple adjacent rows preferably have fields that are identical to the adjacent fields of the other rows, respectively. Fields of several rows are separated into drug pockets, which are then fed to different sub-stacks.
  • this preferred method accordingly comprises the following steps:
  • markings are mounted on consecutive rows in successive marking sections, or where appropriate, a drug pocket having a mark located at a first end of the marker edge on a drug pocket with a a second end of the mar-
  • the method may comprise the following method steps:
  • 0 are attached to subsequent fields in successive marking sections, or optionally wherein a drug pocket having a marker located at a first end of the marker edge is followed by a drug pocket having a marker located at a second end of the marker edge;
  • This method according to the invention has the advantage over the prior art that the production of the stacks takes place with greater certainty because medicament pockets which are to be stacked together are initially held together in strips and separated from each other by singulation just before stacking on top of each other , Thereby reduces the risk of errors in the order of drug pockets in the stack. Thus, the correct number of drug pockets and their order in the stack can be made easier.
  • the markings on the drug pockets can be used to verify that the stacks have been properly formed, such as by manually or mechanically paging through the stacks and controlling the order of the markers on stacked drug pockets.
  • the user Since the medicament pockets are provided with the markings in the manner according to the invention, the user has the option, when using a stack, of determining whether or not he / she has already taken a portion of medicament in the current period.
  • the markings on the drug pockets By means of the markings on the drug pockets, the progress of the administration of the drug wafers can thus be controlled.
  • the markers therefore assume, in addition to the general test function, the further function of rapid assignment of a specific drug wafer to a specific ingestion period or time.
  • the drug pocket template for making stacks of drug pockets for storage and provision of drug wafers comprises at least two, preferably at most four, and preferably at most twelve, for example, four, eight, ten, or twelve adjacent rows of each other, preferably transverse to the longitudinal direction of the drug pocket template following fields from which the medicine bags are to be generated by singulation.
  • each drug pocket at a marker edge in each case a mark in one of a plurality of juxtaposed at the marker edge portions.
  • a mark is preferably applied to each drug pocket on the drug pocket template such that the markers are mounted on successive drug pockets in successive marker portions.
  • a drug pocket having a marker located at a first end of the marker edge is followed by a drug pocket having a marker located at a second end of the marker edge.
  • the drug pocket template is used to make a stack of drug pockets used to store and provide drug wafers.
  • the drug pocket template may also be used to make a dispenser device for storing and providing drug wafers.
  • the device comprises i) a stack of drug pockets containing drug wafers preferably each having seven marker portions at a marker edge and a respective marker in one of the marker portions, and ii) a backing on which preferably
  • the drug pocket templates are in the form of sheets containing fields corresponding to the drug pockets.
  • a sheet comprises six adjacent rows of successive drug pockets and in each row seven consecutive drug pockets.
  • four arcs are needed to simultaneously make six stacks.
  • the drug pouches may also be provided in the form of a long band, for example
  • Tape can be wound on a roll (coil) and then unrolled in the transport direction for the process.
  • a band comprises six adjacent rows of the fields for the medicament pockets which extend in the direction of transport parallel to the transport direction.
  • the markers are preferably located in a second drug pocket area.
  • the markers are placed on successive marker sections in a series of successive fields on the drug pocket template so that the markers in drug cell-to-drug-bag change step-by-step in position, ie from the first to the first seventh drug bag. If the medicine bag template contains more than seven fields in each row, for example If there are 14 fields, the sequence of consecutive markings will begin on a row of consecutive fields from the eighth to the fourteenth pocket, etc. then again. That is, it is preferred that there are seven consecutive drug pockets on the drug pocket template in each row in the direction of transport. This results in 5 weekly stack after the separation and stacking of the drug bags, which can eventually be stacked to a monthly stack with 28 drug bags.
  • Such dimensioning of the stacks with drug pockets is particularly advantageous for use in contraception and hormone replacement therapy, because in this case over 0 several weeks, for example, four weeks (28 days), each time a day a drug dose must be taken. By taking 28 medicine bags in a stack, the user can consume one stack at a time for such a cycle.
  • the times in a preferred embodiment are weekdays or calendar days, the latter represented by the numbering of the days of a month.
  • weekdays are preferred and have the advantage over calendar days that the repetition is more frequent than the latter. This allows easier attachment of time information on the carrier, since for the first day only the appropriate day of the week must be selected from the seventy weekdays.
  • the weekdays, calendar days, or other times are preferably applied to the wearer at the beginning of a take-up phase of the drug wafers.
  • the pharmaceutical bag template according to the invention preferably contains pharmaceutical wafers which contain: contraceptive or hormone replacement therapy.
  • pharmaceutical wafers which contain: contraceptive or hormone replacement therapy.
  • drug wafers that are not drug-containing, such as placebo, or even drugs that are different from those of the other drug wafers (two-phase drugs).
  • every 25th-28th drug pocket may contain a series of drug wafers that are placebo. This has the advantage that, for example, in the contraception, in which there are periods in which no medicines are to be taken, the usual intake of the wafers must not be interrupted because the placebos contain no active ingredients.
  • the separating of the at least two adjacent rows on a medicament pocket template from one another along the separating line following, for example, the transport direction is preferably carried out by cutting.
  • the separation of the medicament pockets contained in the strips formed is preferably carried out by cutting or punching.
  • the separation of the strips from each other and the separation of the drug pockets from the strips can also be carried out by punching.
  • the medicament bag template still does not contain any openings for the medicament pockets, they can be introduced during, before or after separation into the medicament pocket template or the medicament pockets, for example by punching.
  • the stack can be subsequently placed on a support.
  • the medicament pockets 5 can be connected to the carrier via a connecting element on the carrier.
  • the drug pockets can be stacked on the carrier and thereby connected to the connecting element. In both cases, the stack receives improved stability from the carrier and can be handled more easily. In addition, the wafers are protected by the carrier against mechanical effects.
  • the medicament pockets can be stacked on top of each other to produce a respective first sub-stack.
  • the medicament bags are preferably held in a carrier for use by the user.
  • the carrier may already include the connecting element or a part of the connecting element. This ensures that the stack produced is already mechanically combined and can not fall apart during subsequent handling. This enables a secure production method.
  • further pharmaceutical bags can be stacked on the first partial stack after the production of a first partial stack so that the further medicament pockets are likewise held by the connecting element.
  • each further sub-stack ie the second, third, fourth sub-stack, etc.
  • each further sub-stack can be stacked on the first sub-stack such that the drug pockets contained in the further sub-stacks are also held by the connecting element.
  • the medicament pockets further preferably have mutually aligned openings through which the connecting element can be passed.
  • the medicament pockets are connected to one another and preferably arranged to be movable relative to one another. This has the advantage of offsetting the small elevations in the drug pockets caused by the drug wafers in the drug pockets.
  • the drug pockets can thereby be stacked in an orderly manner in the stack. In this way, on the one hand, an aesthetically pleasing device is created. On the other hand, the wafers in the stack are mechanically loaded to a lesser extent and thus preserved gently.
  • the carrier also has a guide element for guiding the medicament pockets on the carrier. This ensures that the drug pockets are stacked on the carrier substantially edge to edge and can remain in the following.
  • the drug pockets are placed in cassettes and stacked in each case.
  • this is placed first in the respective cassette, so that the drug pockets can be placed on it.
  • the time indications are preferably mounted on the carrier in such a way that they align with the marking sections on the medicament pockets when the medicament pockets are combined with the carrier.
  • the stack can also be combined exclusively by means of a connecting element, without using a carrier
  • the drug pockets may be connected to the connector rather than to the carrier when stacked in the first manufacturing device.
  • a guide element can also be used in this case in order to be able to stack and hold together the medicament pockets with an edge-to-edge accuracy. The held together by means of the connecting element pocket stack can then
  • the carrier may be formed so that a stack can be easily attached to it. This makes it possible to make the stack interchangeable in the carrier and thus make the carrier with the stack refillable. This allows a complex design of the carrier, since this is not thrown away after the consumption of the wafer but reused.
  • the connecting element may be, for example, a rivet or another connecting element which holds the stack together tamper-proof.
  • the connecting element connects the medicament pockets with each other, so that they are preferably arranged movably relative to one another.
  • the connecting element can consist of two, for example, rod-shaped
  • connecting element 15 shaped connecting element parts, which can be inserted into one another or screwed or glued together, exist.
  • the connecting element may also be rod-shaped.
  • the connecting element can also be formed in a compact construction in which it consists of two parts, wherein when it is assembled, the openings in the medicament pockets almost completely
  • the connecting element may in particular comprise a box-shaped lower part with a web arranged therein for passage through the openings and a top part closing off the box-shaped lower part.
  • the box-shaped lower part of the box-shaped connecting element, a base plate, a seated on the base plate and the drug pockets include partially enclosing and thus guiding wall and the bridge.
  • a connection element is understood to mean a component which is passed through the openings in the medicament pockets and connects the medicament pockets.
  • a rivet and also the web of the compact design can be
  • connecting element can be understood as connecting elements.
  • additional suitable holding devices on the foot and the head of the bridge can be realized, for example, by the box construction consisting of the box-shaped lower part and the upper part.
  • the foot and the head of the bridge can be different too
  • the web can also be designed as a rivet with two web-shaped rivet heads.
  • these can lock together and are preferably not non-destructively detachable from each other, or they can be glued together, welded or with another joining technique
  • connection of the at least two parts which form the connecting element is achieved by positive locking.
  • a rivet is to be understood as meaning a connecting element which consists of at least two parts which engage in one another and in a form-fitting manner with one another
  • the carrier is preferably made of cardboard, plastic or metal.
  • the carrier encloses the pocket stack to protect the individual drug pockets.
  • the carrier may be formed as an elongated strip, which is folded around the stack around.
  • a protruding on one side of the strip front tab may be formed as a lid.
  • a protruding tab on the other side of the strip may be formed as a cover.
  • the cover and lid may be provided with suitable closure means for closing the carrier i ⁇ around the stack, such as a hook and loop, press, magnetic, plug-in, rubber band closure.
  • the time indications can be mounted on the carrier or on the connecting element.
  • the dispenser device containing the stack produced by the method according to the invention is preferably designed to be counterfeit-proof.
  • one or more security features are provided on the device, which allow verification of the authenticity of the device, for example micropcripts, holograms, tilt images or other security features.
  • each drug pocket is preferably one for tearing off a drug containing the drug wafer second drug pocket area of the drug pocket of a
  • perforation introduced first drug pocket area.
  • the perforation may be placed on the drug pocket template prior to applying the mark or only thereafter.
  • the perforation allows the drug wafers to be removed from the stack, such as by tearing or severing a second drug pocket area from the stack.
  • the first medicine bag
  • the perforation is not formed over the entire width of the drug pockets but overall shortened, where it merges into slots at both ends. Through the slots, a notch effect is generated which further simplifies the separation of the second medicament pocket regions.
  • the introduction of the perforation can be done for example by suitable punching tools.
  • a further step is provided before the stacking of the separated medicament pockets, in which the medicament pockets are provided.
  • each provided with a peripheral recess wherein the recesses in the stack of drug bag to drug bag are incrementally larger, so that seen across all drug bags in the stack forms a staircase shape of the recesses and thus made visible on the drug pockets markings.
  • graphical marks for example in the form of a symbol, such as a colored colon, a smiley, a logo or a cross bar, applied, which are gradually removed by the introduction of the recesses.
  • the recesses for example, during the manufacturing process from the Pharmaceutical bag can be punched out in the finished stack the view of each visible in the area of the recess graphic mark on the underlying drug stack in the stack.
  • These graphic marks may already be printed on the medicine bag template.
  • the recesses and the thereby recognizable graphical marks have the advantage that the production personnel or a suitable control device in the production of the stack can easily check its completeness and thus the number of drug pockets in the stack.
  • this mark is applied to one of the aluminum layers or one of the polyethylene terephthalate layers.
  • Fig. 1 shows a schematic representation of the process sequence of the method according to the invention
  • Fig. 2 shows the layout of a sheet from which drug pockets are obtained by punching;
  • Fig. 2a variant of the sheet of Fig. 2;
  • Fig. 3 is a perspective view of a stack made of a drug pocket template in an embodiment of the present invention.
  • FIG. 4 shows a further embodiment according to the invention of a wafer pocket staple containing a pocket stack produced by the method according to the invention in various assembly stages in a perspective view;
  • Fig. 4a shows a further embodiment according to the invention of a wafer pocket staple containing a pocket stack produced by the method according to the invention in various assembly stages in a perspective view;
  • Fig. 4a shows a further embodiment according to the invention of a wafer pocket staple containing a pocket stack produced by the method according to the invention in various assembly stages in a perspective view;
  • FIG. 4b wafer pocket book open
  • Fig. 4c wafer pocket booklet closed
  • Fig. 4d wafer pocket booklet in side view
  • FIG. 4e shows an alternative embodiment with a rubber band for closing the wafer pocket staple
  • FIG. Fig. 4f alternative embodiment with tab for closing the wafer pocket booklet
  • Fig. 4g alternative embodiment with magnetic closure;
  • FIG. 5 shows a further embodiment according to the invention of a wafer pocket stack containing a pocket stack produced by the method according to the invention in various assembly stages in a perspective view
  • FIG. Fig. 5a Vehicle before stapling the pile
  • Fig. 5b-1 stack and connecting element with each guide individually
  • Figures 5b-2 as assembled and stapled as Figure 5b-1 stack and connector
  • FIG. 5c after connection to the carrier, open wafer pocket
  • FIG. Fig. 5d wafer pocket booklet closed;
  • FIG. 6 shows a further embodiment according to the invention of a wafer pocket stack containing a pocket stack produced by the process according to the invention in various assembly stages in a perspective view;
  • FIG. Fig. 6a carrier with connecting element and guide;
  • Fig. 6b, 6c after installation of the stack, Wafertaschenheft fully or partially open;
  • Fig. 6d wafer pocket booklet
  • FIG. 6e like FIG. 6a, with another arrangement of the weekday strip
  • FIG. 7 shows a further side view of another embodiment according to the invention of a wafer pocket booklet containing a stack produced by the method according to the invention
  • FIG. 8 shows yet another embodiment according to the invention of a
  • Fig. 1 the process sequence according to the invention is schematically represented by the drug templates and manufacturing devices used in the preparation of the stack.
  • the elements shown may represent devices which may be used to carry out the method. However, other designs can also be used
  • the sheets 7 containing the medicament pockets in the form of fields are fed to punching devices 26, 26 'in modules 30, 30', 30 "The number of modules depends on the total number of medicament pockets 4 to be accommodated in a pocket stack and the number of io on one Sheet containing drug bag pockets in a row, ie the number of drug pockets supplied to each module, for example, if you want to total 28 medicine bags in a stack and seven Pharmaceutical bags in a row are on an arc, four modules must be provided.
  • the fields are arranged in rows R and columns S. In the present case, six rows and seven columns are provided. The rows and columns are indicated by arrows in FIG. 2 by way of example.
  • the fields in a row on an arc are assigned to a stack. Fields of different series can be assigned to different stacks. 0
  • Fields 8 'for perforations as well as marking sections 18 at a marking edge of the respective field can be seen in fields 5.
  • Markers 3 are applied within the marking portions, for example by a printing process, to facilitate the user's control of the regular ingestion. It can be seen that the position of the marks on the marking edge are the same in different rows but the same columns, while the positions of the marks in successive fields in a row follow each other: Seen from below, the marks are in the lowest, second lowest , third lowest marking section and so on.
  • the illustrated adjacent six rows R, each with seven fields 5, are first cut according to the invention along the dividing lines 11 into six strips 9, before the medicament pockets are separated from the strips 9.
  • One strip is then further processed by separating each individual drug bag.
  • the thus separated drug bags are then stacked on each other, for example, to weekly stacks.
  • another sheet 7 is processed according to the same procedure. From a sheet, for example, six weekly stacks are generated. By placing in each case a further 21 medicament pockets on the six first week stacks obtained from a first sheet 7, which are obtained from three further sheets 7, a total of six stacks are formed, each containing 28 medicament pockets. By preferably first generates the strip 9
  • the drug pockets are cut from the respective strips or separated by punching, the belonging to a stack drug pockets are held together as long as possible in the form of the strip. Only immediately before the stacking of the drug pockets these are according to this procedure of the strip 13 separated. Thus, mis-sorting is avoided, so that the security in the production of the stack is increased.
  • FIG. 2a A variant of the drug pocket template of FIG. 2 is shown in FIG. 2a.
  • This template 5 7 differs from that described above in that eight rows R of seven fields 5 are provided for the production of drug pockets.
  • each panel has an oval opening 8 which is punched out, a perforation 12, via which a first medicament pocket area and a second medicament pocket area are connected to one another, and lateral indentations 13 at the perforations.
  • These perforations 15 serve to transport the original 7, as in a film transport.
  • the rows R of the sheet 7 are arranged parallel to a direction in which the sheet is conveyed in the manufacture of the medicament pockets (arrow 10).
  • the marking sections 18 and markings 3 in the marking sections can be seen on the fields 5.
  • the positions of the marks 3 change step by step from field to field. In contrast, the positions of the markers 3 within a column S remain unchanged.
  • the original 7 of Fig. 2a differs from that described above according to FIG. 2 in that eight rows R of seven fields 5 are provided for the production of drug pockets.
  • Each of the modules 30, 30 ', 30 is fed with two such sheets 7 (see arrows in Fig. 1) as shown in Fig. 1.
  • the areas on the sheets corresponding to the individual rows R and columns S are also shown in Fig. 1 shown schematically.
  • the sheets 7 are simultaneously placed on the punching tables 27, 27 'of the punching devices 26, 26' 0. There, the drug pockets 4 are punched out according to the field border in Fig. 2, 2a. At the same time the openings 8 are formed by punching.
  • the punching tables can be moved in parallel according to the arrows. As a result, an arc can be arranged under the punching device before punching and, if appropriate, aligned and moved the punching of the drug pockets from the punching area (in Fig. 1 upwards) are moved.
  • the punching process takes place
  • Special robot arms (not shown) which are equipped with a sensor system are used to remove the individual medicament pockets 4, in order to ensure that the individually accommodated medicament pouches are safely picked up, safely transported and safely deposited again.
  • modules 30, 30 ', 30 are each twelve cassettes.Therefore, two sheets 7 can be fed simultaneously to a module, because each sheet contains six drug pockets rows R. The sheets supplied to the individual modules 7 are simultaneously! In addition, the punched-out drug pockets 4 of a given column S in each module are simultaneously placed in the cassettes.
  • each first sub-stack has seven drug pockets in the first module 30.
  • second sub-stacks have already been created by stacking seven drug pockets on the first sub-stack
  • the second sub-stacks already contain 14 drug pockets, etc.
  • first module 30 again formed first partial stack of drug pockets.
  • other modules 30 ', 30 "further medicament pockets are added to the already existing partial stacks, so that in the present case in the second module 30' partial stack with 14, in the third module substacks with 21 and in the fourth module 30" finished stack with 28 drug pockets be formed.
  • Figure 3 shows a stack 100 of pharmaceutical bags 4, 4 ', 4 "prepared for storage and provision of drug wafers 2, wherein the drug pockets are connected together after stacking or already during stacking '4', 4 '' has a marking 3 in each case at one marking edge in one of a plurality of side by side on the marking edge.
  • the medicament pockets 4, 4 ', 4 “have second medicament pocket regions 11 and first medicament pocket regions 10, each having a mutually aligned opening 8.
  • the connecting element 200 is passed through the opening 8.
  • the connecting element 200 connects the medicament pockets 4 with one another and arranges them movably relative to one another
  • the i ⁇ opening 8 is formed as a slot and the connecting element 200 is formed as a rivet, the first medicament pocket areas 10 and the second medicament pocket areas 11 are each connected to one another via a perforation 12, so that the separation of the medicament wafer 2, which is located in the second medicament pocket area 11, from the first drug area 10 at the perforation 12 is facilitated. In this case, the first drug pocket area 10 remains in the stack 100.
  • FIG. 4 shows a further embodiment of a method according to the invention
  • FIG. 5 produced pocket stack containing 100 wafer pocket booklet shown in perspective view.
  • the wafer pocket stack 100 of FIG. 4 is substantially similar to the structure of the wafer pocket booklet of FIG. 3, but unlike FIG. 3, the markers 3 and marker portions 18 are not adjacent the perforation 12, but at the opposite edge of the drug pocket areas 11th
  • the pocket stack 100 comprises a multiplicity of medicament pockets 4, 4 ', 4 ", for example 28 pockets, of which only the topmost medicament pocket 4 is visible.
  • the medicament pockets 4, 4', 4" have second medicament pocket regions 11 and first medicament pocket regions 10.
  • the drug pockets each contain a welded wafer 2.
  • Marking sections 18 are located on one of the marking sections on the lower edge 17, which is a marking edge.
  • a marking 3 is located on one of the marking sections. In the second medicament bag (not visible) located under the upper visible medicament bag, this marking is applied to the marking section adjacent to the marking section first marker portion, in which the marker is located on the uppermost drug pocket.
  • the first drug pocket regions 10 and the second drug pocket regions 11 are each interconnected via a perforation 12, the overall perforation being shorter than in FIG. 3, i. does not extend over the entire width of the medicament pockets 4, 4 ', 4 ", but at its two ends merges into slots 13, 13' which act like a
  • the removal of the drug wafer 2 is facilitated by even easier separation of the second drug pocket area 11 from the first drug pocket area 10 at the perforation 12.
  • the first drug pocket area 10 remains in the wafer pocket booklet after separation of the second drug pocket area 11.
  • the drug pockets each have a mutually aligned opening, here in i ⁇ shape of an elongated hole, 8, through which engages in the assembled state of the booklet of the rivet 200 and a ridge.
  • the drug pockets 4, 4 ', 4 are in this embodiment, in contrast to that of Fig. 3 by a compact connecting element 200, consisting of a lower connecting element part 210 and an upper connecting element part 220, which completely fills the opening 8 in the assembled state where the connection element
  • the rivet has a base 210 and a top 220. The lower part engages from below through the slots 8 therethrough.
  • the columnar rivet brackets 211, 212 are mounted on a base plate 213 spaced from each other so that the outer edges of the rivet holders loosely abut the rounded slot ends. These outer edges are after
  • O medicine bags have it on vertical play. As a result, the difference in thickness of the wafer pocket areas on the pockets can be taken into account with respect to the remaining areas.
  • the medicine bags also slide frictionless on the rivet.
  • the lower connector part 210 is held by a holder or optionally a carrier, and the singulated drug pockets 4, 4 ', 4 "or the finished stack 100 are placed over the openings 8 on the lower connector part 210 Subsequently, the connecting member 200 is closed by fitting the upper connecting member 220.
  • the rivet base 210 is preferably mounted on a carrier strip 300.
  • the carrier strips together with the rivet lower part are preferably first inserted into the cassettes 25, 25 ', 25 ", 25'",... (FIG. 1).
  • the drug bags are then placed on this strip, the on
  • the rivet base fixed to the carrier strip in each case slides into the slot 8 of the pockets and guides the pockets to one side, ie determines their position and holds them to the other one as well.
  • the carrier strip 300 After the stacking of all drug pockets of a wafer pocket booklet, the carrier strip 300 is provided with a weekday strip 350.
  • the weekday strip is attached to the marking portions 18 on the drug pockets 4, 4 '. As a result, the user can recognize on which day of the week the wafer 2 of the medicament bag 4 lying overhead must be taken.
  • the carrier strip 300 is then folded over at both the upper and lower ends so that the upper end forms a cover 320 for the wafer pocket booklet.
  • the cover may contain information about the manufacturer and the name of the medicine.
  • the cover extends substantially over the entire surface of the drug pockets 4. It is fixed after being folded over by pressing the rivet shell 220 between the columnar rivet holders 211, 212 of the rivet lower part 210.
  • the lower end of the carrier strip 300 is also folded over so that it forms a lid 330 for the drug pockets 4.
  • the closed state of the wafer pocket booklet can be seen in FIG. 4c.
  • the cover 330 engages over the cover 320.
  • Both parts are connected to one another via a releasable closure.
  • velcro fasteners 410, 420 may be attached to the inside of the lid and to the outside of the cover.
  • the hook and loop fasteners are shown in Fig. 4d.
  • a magnetic closure is shown in Fig. 4g.
  • a metal strip is preferably applied over the entire width of the lid, and on the edge region of the cover 320, for example, a magnetized metal strip is also preferably applied over the entire width of the cover.
  • FIG. 4e An alternative embodiment of the wafer pocket booklet is shown in Fig. 4e: Instead of the hook and loop fastener or the magnetic closure, a rubber band 430 is provided, which is attached to the lower part of the carrier 300 and pulled over the cover 320 to close the booklet.
  • FIG. 4f Another embodiment of the wafer pocket booklet is shown in FIG. 4f.
  • a tab formed by punching and downwardly bent tab 440 is provided on the cover 320, which can engage in a slot 450 in the lid 330 when the wafer pocket folder is closed.
  • FIG. 5 shows a perspective view of another embodiment of a wafer pocket booklet containing a pocket stack 100 produced by the method according to the invention in various assembly stages.
  • the pocket stack 100 comprises a multiplicity of medicament pockets 4, for example 28 pockets, of which only the uppermost medicament pouch is visible.
  • the drug pocket contains a shrink-wrapped wafer 2.
  • On one of the marker portions is a marker 3.
  • this mark is placed on the marking portion adjacent to the first marking portion where the mark is on the uppermost drug pocket.
  • the medicament pockets 4 are notched on two sides in the upper area at 13, 13 'and have a perforation 12.
  • the medicament pockets have slots 8 through which a web 214 engages in the assembled state of the booklet.
  • the fastening device 200 is shown above the pocket stack 100, which is constructed in two parts:
  • the fastening device has a lower part 210 and an upper part 220.
  • the lower part comprises a web 214 and a frame 215, both of which are mounted on a base plate 213.
  • the web engages from below through the slots 8 therethrough.
  • the frame 215 partially bounds the base plate on three sides as well as on the fourth side. Where this frame is not located, the drug pockets may extend through a connector having the perforation.
  • this frame surrounds the upper (first) part of the drug pockets flush and thus represents an external guide for the drug pockets, so that they sit firmly in the wafer pocket booklet without play.
  • the upper part of the fastening device is formed by a plate 220, which can be positively or materially fixed to the lower part.
  • the plate In cohesive connection, the plate be connected for example by means of ultrasonic welding to the lower part.
  • For a positive connection for example undercuts on one of the two parts and projecting parts are provided on the other of the two parts.
  • the (stitched) pocket stack 100 can be easily handled without fear of compromising the integrity of the stack during handling.
  • the lower part 210 of the fastening device 200 is preferably fastened on a carrier strip IO 300, for example by gluing. If a first sub-stack is generated to produce the stack of drug pockets, the carrier strip when it is generated from drug pockets 4 with the base 210 is preferably first in the respective cassette 25, 25 ', 25 ", 25'", ... (Fig. 1) inserted. The drug pockets are then placed on top of this strip, with the web 214 of the base 210 secured to the carrier strip sliding into the slot 8 of the pockets in FIG. 5, respectively. Through this web and the frame 215, the drug pockets are held on the carrier strip. In addition, the position of the medicine bags is precisely defined.
  • the carrier strip 300 is provided with a weekday strip 350.
  • the weekday strip is mounted so that it is aligned with the marking sections 18 and thus with a respective marking 3 on the medicament pockets 4. As a result, the user can recognize on which day of the week the wafer of the overhead medicament bag must be taken.
  • the carrier strip 300 is then folded over both at the lower end so that this end forms a lid 330 for the wafer handle.
  • a lid 330 for the wafer handle.
  • information about the manufacturer and the name of the medicine may be appropriate on the lid.
  • the lid extends in this case substantially over the entire surface of the drug pockets.
  • the upper end of the carrier strip 300 is not folded over.
  • the fastening device 200 forms a box which closes the wafer pocket booklet at the upper edge.
  • the closed state of the wafer pocket booklet can be seen in FIG. 5d.
  • the lid 330 extends over the attachment device. Both parts are available via a detachable Closely connected. For example, can be attached to the inside of the lid and on the outside of the fastening device magnetic fasteners, for example, on one side of a metal strip and on the other side of a magnetized metal strip.
  • the partial elements of the magnetic closure can also be hidden in the respective component parts.
  • FIG. 6 also shows a perspective view of another embodiment of a wafer pocket booklet containing a pocket stack 100 produced by the method according to the invention in various stages of assembly.
  • the pocket stack 100 comprises a multiplicity of medicament pockets, for example 28 pockets, of which only the topmost medicament pocket 4 is visible.
  • the drug pocket contains a welded wafer 2.
  • the medicament pockets 4 are notched on both sides in the upper area at 13, 13 'and have a perforation 12.
  • the drug pockets have slots 8 through which a web 214 engages in the assembled state of the booklet.
  • the fastening device 200 is shown on the carrier strip 300.
  • the fastening device is constructed in two parts: it has a lower part 210 and an upper part 220.
  • the lower part comprises a web 214, a frame 215 and a base plate 213.
  • the web engages from below through the slots 8 therethrough.
  • the frame 215 is seated on the edge of the base plate 213. It partially limits the base plate on three sides as well as on the fourth side. Where this frame is not located, the drug pockets 4 can pass through a connector having the perforation. Incidentally, this encompasses
  • the upper part of the attachment is through the plate 220 formed, which can be positively or materially secured on the lower part.
  • This plate 220 is connected to the carrier strip 300, for example, a material fit (by gluing or the like).
  • the lower part 210 of the fastening device 200 is fastened to the carrier strip 300, for example by gluing.
  • the carrier strips with the lower part 210 are preferably presented or first inserted into the cassettes 25, 25 ', 25 ", 25'",... (FIG. 1) ,
  • the drug pockets are then placed on this strip, wherein the web 214 of the carrier strip attached to the lower part of the fastening device in each case slides into the slot 8 of the pockets.
  • the frame 215 the drug pockets are held on the carrier strip. In addition, their position is precisely determined by the frame.
  • the carrier strip 300 is provided with a weekday strip 350.
  • the weekday strip may be attached to both the position shown in Fig. 6a and at the position shown in Fig. 6e.
  • the weekday strip is mounted so that it aligns with the marking portions 18 on the drug pockets 4. As a result, the user can recognize on which day of the week the wafer of the overhead medicament bag must be taken.
  • the carrier strip 300 is then folded over at the upper end so that the end forms a cover 320 for the wafer pocket booklet.
  • the cover may contain information about the manufacturer and the name of the medicine.
  • the cover extends over the entire surface of the drug pockets 4 and over the supernatant of the carrier at the bottom of the booklet.
  • the lower end of the carrier strip 300 is folded so that the block 340 results.
  • the cover 320 engages over the block. Both parts are connected by a releasable closure.
  • magnetic closures may be attached to the inside of the cover and to the outside of the block.
  • the wafer pocket booklet is assembled.
  • Fig. 7 yet another embodiment of the wafer pocket booklet is shown.
  • the cover 330 of the carrier 300 is pulled from below over the pocket stack 100 and covers it in the closed state.
  • a rivet has been used as connecting element 200. This rivet simultaneously serves as a closure for the wafer pocket booklet together with a corresponding opening in the lid by inserting a protruding part of the rivet into a hole in the lid.
  • FIG. 8 shows a perspective view of a wafer pocket booklet produced from a medicament pocket template with a stack 100 substantially analogous to FIG. 4, wherein, however, the medicament pockets 4, 4 ', 4 "additionally each have a lateral recess 16.
  • the recesses 16 are located in each case at an edge of the drug pockets 4, 4 ', 4 "shared by the first and second drug pouches 10, 11, the individual pouches in the successive drug pouches 4, 4', 4" being configured to be from drug pouch
  • a step-shaped course of the recesses 16 from medicament pocket to medicament pocket results.
  • the stack 100 is arranged on a carrier 300 in this embodiment.
  • the stack 100 and the carrier are interconnected by three rivets 200, 200 ', 200 ", or alternatively, only one rivet 200' or, for example, the connector of Figure 4 could be used to connect the stack 100 to the carrier resting drug bag 4 are in the second drug pocket area 11, the marker 3 and the marker sections 18 can be seen.
  • the carrier 300 in this embodiment has a region 360 projecting beyond the lower edge of the second medicament pocket regions 11 and time indications in this region 350 (a weekday strip), wherein the times, here weekdays, aligned with the marker sections 18.
  • the time indications 350 are applied, for example, by gluing and have the weekly data "Mo", “Di”, “Wed”, “Do”, “Fr”, “Sa”, “So”
  • the first day of the week is displayed on the leftmost side of the medication bag 4, and a first marking 3 aligned with the day of the week "Mo” is attached. Further markings 3 are not shown, since these are covered by the overlying drug pockets 4.

Abstract

L'objectif de l'invention est de permettre de produire, de manière sûre, des empilements (100) de pochettes (4, 4', 4") contenant des médicaments sous forme stratifiée et présentant chacune, sur un bord de repérage (17), un repère (3) dans une partie de repérage d'une pluralité de parties de repérage (18) juxtaposées. À cet effet, on met en oeuvre le procédé suivant consistant à : empiler les pochettes (4, 4', 4") pour former au moins un empilement (100) de pochettes, de sorte que dans ledit au moins un empilement se succèdent des pochettes (4, 4', 4") dont les repères (3) se trouvent dans des parties de repérage (18) consécutives et de sorte qu'éventuellement une pochette (4, 4', 4") présentant un repère (3) se trouvant à une première extrémité du bord de repérage (17) suive une pochette (4, 4', 4") présentant un repère (3) se trouvant à une deuxième extrémité du bord de repérage (17).
EP10702625A 2009-02-06 2010-02-03 Procédé pour produire un empilement de pochettes servant à conserver et à mettre à disposition des médicaments sous forme stratifiée, modèle de pochette pour produire ledit empilement et utilisation dudit modèle Withdrawn EP2393467A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE200910008028 DE102009008028A1 (de) 2009-02-06 2009-02-06 Verfahren zur Herstellung eines Taschenstapels von zur Aufbewahrung und Bereitstellung von Arzneimittelwafern dienenden Arzneimitteltaschen
DE102009008026A DE102009008026A1 (de) 2009-02-06 2009-02-06 Verfahren zur Herstellung eines Stapels von Arzneimitteltaschen, Arzneimitteltaschenvorlage zur Herstellung des Stapels sowie Verwendung der Arzneimitteltaschenvorlage
PCT/EP2010/000647 WO2010089091A1 (fr) 2009-02-06 2010-02-03 Procédé pour produire un empilement de pochettes servant à conserver et à mettre à disposition des médicaments sous forme stratifiée, modèle de pochette pour produire ledit empilement et utilisation dudit modèle

Publications (1)

Publication Number Publication Date
EP2393467A1 true EP2393467A1 (fr) 2011-12-14

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EP10702625A Withdrawn EP2393467A1 (fr) 2009-02-06 2010-02-03 Procédé pour produire un empilement de pochettes servant à conserver et à mettre à disposition des médicaments sous forme stratifiée, modèle de pochette pour produire ledit empilement et utilisation dudit modèle

Country Status (10)

Country Link
US (1) US20110289888A1 (fr)
EP (1) EP2393467A1 (fr)
JP (1) JP2012516726A (fr)
KR (1) KR20110116156A (fr)
CN (1) CN102307554A (fr)
AU (1) AU2010211258A1 (fr)
BR (1) BRPI1008017A2 (fr)
CA (1) CA2751429A1 (fr)
IL (1) IL213968A0 (fr)
WO (1) WO2010089091A1 (fr)

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EP3135602A1 (fr) * 2015-08-25 2017-03-01 Bayer Pharma Aktiengesellschaft Blister
US10265243B2 (en) 2015-09-08 2019-04-23 Accredo Health Group, Inc. Medication dispensing system

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Also Published As

Publication number Publication date
IL213968A0 (en) 2011-08-31
KR20110116156A (ko) 2011-10-25
US20110289888A1 (en) 2011-12-01
WO2010089091A1 (fr) 2010-08-12
BRPI1008017A2 (pt) 2016-03-15
CA2751429A1 (fr) 2010-08-12
AU2010211258A1 (en) 2011-09-08
JP2012516726A (ja) 2012-07-26
CN102307554A (zh) 2012-01-04

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