EP2304420A4 - METHODS AND APPARATUS FOR DETECTING MOLECULAR INTERACTIONS USING FET ARRAYS - Google Patents

METHODS AND APPARATUS FOR DETECTING MOLECULAR INTERACTIONS USING FET ARRAYS

Info

Publication number
EP2304420A4
EP2304420A4 EP09770544.6A EP09770544A EP2304420A4 EP 2304420 A4 EP2304420 A4 EP 2304420A4 EP 09770544 A EP09770544 A EP 09770544A EP 2304420 A4 EP2304420 A4 EP 2304420A4
Authority
EP
European Patent Office
Prior art keywords
arrays
methods
fet
improved
molecular interactions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP09770544.6A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP2304420A2 (en
Inventor
Jonathan M Rothberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Life Technologies Corp
Original Assignee
Life Technologies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Life Technologies Corp filed Critical Life Technologies Corp
Priority to EP19193875.2A priority Critical patent/EP3650847A1/en
Publication of EP2304420A2 publication Critical patent/EP2304420A2/en
Publication of EP2304420A4 publication Critical patent/EP2304420A4/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4148—Integrated circuits therefor, e.g. fabricated by CMOS processing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Electrochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP09770544.6A 2008-06-26 2009-06-26 METHODS AND APPARATUS FOR DETECTING MOLECULAR INTERACTIONS USING FET ARRAYS Ceased EP2304420A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP19193875.2A EP3650847A1 (en) 2008-06-26 2009-06-26 Methods and apparatus for detecting molecular interactions using fet arrays

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13320408P 2008-06-26 2008-06-26
PCT/US2009/003797 WO2009158006A2 (en) 2008-06-26 2009-06-26 Methods and apparatus for detecting molecular interactions using fet arrays

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP19193875.2A Division EP3650847A1 (en) 2008-06-26 2009-06-26 Methods and apparatus for detecting molecular interactions using fet arrays

Publications (2)

Publication Number Publication Date
EP2304420A2 EP2304420A2 (en) 2011-04-06
EP2304420A4 true EP2304420A4 (en) 2013-10-30

Family

ID=41445144

Family Applications (2)

Application Number Title Priority Date Filing Date
EP09770544.6A Ceased EP2304420A4 (en) 2008-06-26 2009-06-26 METHODS AND APPARATUS FOR DETECTING MOLECULAR INTERACTIONS USING FET ARRAYS
EP19193875.2A Withdrawn EP3650847A1 (en) 2008-06-26 2009-06-26 Methods and apparatus for detecting molecular interactions using fet arrays

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP19193875.2A Withdrawn EP3650847A1 (en) 2008-06-26 2009-06-26 Methods and apparatus for detecting molecular interactions using fet arrays

Country Status (4)

Country Link
EP (2) EP2304420A4 (enExample)
JP (1) JP2011525990A (enExample)
CN (1) CN102203597A (enExample)
WO (1) WO2009158006A2 (enExample)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
EP2677309B9 (en) 2006-12-14 2014-11-19 Life Technologies Corporation Methods for sequencing a nucleic acid using large scale FET arrays, configured to measure a limited pH range
WO2010008480A2 (en) 2008-06-25 2010-01-21 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes using large scale fet arrays
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US8574835B2 (en) 2009-05-29 2013-11-05 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
US8673627B2 (en) 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
US8052931B2 (en) * 2010-01-04 2011-11-08 International Business Machines Corporation Ultra low-power CMOS based bio-sensor circuit
US20120035062A1 (en) 2010-06-11 2012-02-09 Life Technologies Corporation Alternative nucleotide flows in sequencing-by-synthesis methods
JP2013533482A (ja) 2010-06-30 2013-08-22 ライフ テクノロジーズ コーポレーション イオン感応性電荷蓄積回路および方法
US8432149B2 (en) * 2010-06-30 2013-04-30 Life Technologies Corporation Array column integrator
US11307166B2 (en) 2010-07-01 2022-04-19 Life Technologies Corporation Column ADC
EP2617061B1 (en) 2010-09-15 2021-06-30 Life Technologies Corporation Methods and apparatus for measuring analytes
CN103299182A (zh) * 2010-09-24 2013-09-11 生命科技公司 匹配的晶体管对电路
US20130189699A1 (en) 2010-10-08 2013-07-25 Dna Electronics Limited Ionic signal enhancement
GB2484339B (en) * 2010-10-08 2016-12-21 Dnae Group Holdings Ltd Electrostatic discharge protection
EP2633470B1 (en) 2010-10-27 2016-10-26 Life Technologies Corporation Predictive model for use in sequencing-by-synthesis
US10273540B2 (en) 2010-10-27 2019-04-30 Life Technologies Corporation Methods and apparatuses for estimating parameters in a predictive model for use in sequencing-by-synthesis
WO2012118555A1 (en) 2010-12-29 2012-09-07 Life Technologies Corporation Time-warped background signal for sequencing-by-synthesis operations
EP2658999B1 (en) 2010-12-30 2019-03-13 Life Technologies Corporation Models for analyzing data from sequencing-by-synthesis operations
US20130060482A1 (en) 2010-12-30 2013-03-07 Life Technologies Corporation Methods, systems, and computer readable media for making base calls in nucleic acid sequencing
WO2012092515A2 (en) 2010-12-30 2012-07-05 Life Technologies Corporation Methods, systems, and computer readable media for nucleic acid sequencing
US8594951B2 (en) 2011-02-01 2013-11-26 Life Technologies Corporation Methods and systems for nucleic acid sequence analysis
WO2012138921A1 (en) 2011-04-08 2012-10-11 Life Technologies Corporation Phase-protecting reagent flow orderings for use in sequencing-by-synthesis
US11435358B2 (en) 2011-06-23 2022-09-06 Board Of Regents, The University Of Texas System Single molecule peptide sequencing
AU2012281242B2 (en) 2011-07-08 2016-12-22 Keygene N.V. Sequence based genotyping based on oligonucleotide ligation assays
US10704164B2 (en) 2011-08-31 2020-07-07 Life Technologies Corporation Methods, systems, computer readable media, and kits for sample identification
US20150087537A1 (en) 2011-08-31 2015-03-26 Life Technologies Corporation Methods, Systems, Computer Readable Media, and Kits for Sample Identification
US9970984B2 (en) 2011-12-01 2018-05-15 Life Technologies Corporation Method and apparatus for identifying defects in a chemical sensor array
KR101301007B1 (ko) 2011-12-05 2013-08-29 한국과학기술연구원 혈관 내 피에이치 측정을 위한 플렉시블 피에이치 센서
WO2013096404A1 (en) * 2011-12-22 2013-06-27 Becton, Dickinson And Company Methods and apparatus for rapid detection of infectious microorganisms
JP5566543B2 (ja) * 2012-03-30 2014-08-06 国立大学法人九州大学 センサ、検出方法、検出システム、及び、検出装置
US9646132B2 (en) 2012-05-11 2017-05-09 Life Technologies Corporation Models for analyzing data from sequencing-by-synthesis operations
US8786331B2 (en) 2012-05-29 2014-07-22 Life Technologies Corporation System for reducing noise in a chemical sensor array
US10329608B2 (en) 2012-10-10 2019-06-25 Life Technologies Corporation Methods, systems, and computer readable media for repeat sequencing
JP6031954B2 (ja) * 2012-11-14 2016-11-24 ソニー株式会社 発光素子、表示装置及び電子機器
US9080968B2 (en) 2013-01-04 2015-07-14 Life Technologies Corporation Methods and systems for point of use removal of sacrificial material
US9841398B2 (en) 2013-01-08 2017-12-12 Life Technologies Corporation Methods for manufacturing well structures for low-noise chemical sensors
US8962366B2 (en) 2013-01-28 2015-02-24 Life Technologies Corporation Self-aligned well structures for low-noise chemical sensors
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
US8841217B1 (en) 2013-03-13 2014-09-23 Life Technologies Corporation Chemical sensor with protruded sensor surface
US20140296080A1 (en) 2013-03-14 2014-10-02 Life Technologies Corporation Methods, Systems, and Computer Readable Media for Evaluating Variant Likelihood
WO2014151961A1 (en) * 2013-03-14 2014-09-25 Life Technologies Corporation Matrix arrays and methods for making same
US9116117B2 (en) 2013-03-15 2015-08-25 Life Technologies Corporation Chemical sensor with sidewall sensor surface
CN105283758B (zh) 2013-03-15 2018-06-05 生命科技公司 具有一致传感器表面区域的化学传感器
WO2014149780A1 (en) 2013-03-15 2014-09-25 Life Technologies Corporation Chemical sensor with consistent sensor surface areas
EP2972281B1 (en) 2013-03-15 2023-07-26 Life Technologies Corporation Chemical device with thin conductive element
US9835585B2 (en) 2013-03-15 2017-12-05 Life Technologies Corporation Chemical sensor with protruded sensor surface
US20140336063A1 (en) 2013-05-09 2014-11-13 Life Technologies Corporation Windowed Sequencing
US10458942B2 (en) 2013-06-10 2019-10-29 Life Technologies Corporation Chemical sensor array having multiple sensors per well
JP6532456B2 (ja) 2013-10-04 2019-06-19 ライフ テクノロジーズ コーポレーション 終止化学を用いる配列決定における整相効果（ｐｈａｓｉｎｇ ｅｆｆｅｃｔｓ）をモデル化するための方法及びシステム
EP4220137A1 (en) 2013-12-10 2023-08-02 Illumina, Inc. Biosensors for biological or chemical analysis and methods of manufacturing the same
WO2016060974A1 (en) 2014-10-13 2016-04-21 Life Technologies Corporation Methods, systems, and computer-readable media for accelerated base calling
TWI756167B (zh) 2014-12-18 2022-03-01 美商生命技術公司 積體電路裝置、感測器裝置及積體電路
CN107407656B (zh) 2014-12-18 2020-04-07 生命科技公司 使用大规模 fet 阵列测量分析物的方法和装置
US10077472B2 (en) 2014-12-18 2018-09-18 Life Technologies Corporation High data rate integrated circuit with power management
CN104730137A (zh) * 2015-03-27 2015-06-24 中国科学院上海微系统与信息技术研究所 基于超薄绝缘层soi上的mosfet背栅生物传感器及其制备方法
EP4220645A3 (en) 2015-05-14 2023-11-08 Life Technologies Corporation Barcode sequences, and related systems and methods
EP3332033B1 (en) 2015-08-06 2021-04-21 Pacific Biosciences of California, Inc. Single-molecule nanofet sequencing systems and methods
US9678037B2 (en) 2015-10-08 2017-06-13 The Regents Of The University Of Michigan Two-dimensional material-based field-effect transistor sensors
CN105543071A (zh) * 2015-12-10 2016-05-04 严媚 一种用于高通量基因测序的cmos isfet双模式图像化学传感器芯片
CN105758919A (zh) * 2016-03-01 2016-07-13 杭州格磊思沃科技有限公司 半导体疾病芯片的制造方法
US10619205B2 (en) 2016-05-06 2020-04-14 Life Technologies Corporation Combinatorial barcode sequences, and related systems and methods
US10724089B2 (en) 2016-10-06 2020-07-28 The Board Of Trustees Of The University Of Illinois Spatial molecular analysis of tissue
CN110312932B (zh) * 2016-11-07 2021-12-21 Dnae诊断有限公司 化学敏感场效应晶体管阵列
SG10201709799SA (en) * 2016-11-29 2018-06-28 Helios Bioelectronics Inc Method for quantitatively profiling nucleic acids
CN108732225B (zh) * 2017-04-19 2021-07-13 中芯国际集成电路制造(上海)有限公司 离子敏感场效应晶体管及其形成方法
AU2019301750A1 (en) 2018-07-12 2021-01-28 Board Of Regents, The University Of Texas System Molecular neighborhood detection by oligonucleotides
WO2020072907A1 (en) 2018-10-05 2020-04-09 Board Of Regents, The University Of Texas System Solid-phase n-terminal peptide capture and release
US12644159B2 (en) 2019-12-09 2026-06-02 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Institute) Device and methods for detecting fungal pathogenicity in postharvest produce
WO2021211631A2 (en) * 2020-04-13 2021-10-21 Erisyon Inc. Single molecule n-terminal sequencing using electrical signals
CN116075596A (zh) 2020-08-07 2023-05-05 牛津纳米孔科技公开有限公司 鉴定核酸条形码的方法
CN113985959B (zh) * 2021-10-27 2024-03-26 中国科学院高能物理研究所 开关电容阵列芯片间时间差的校正方法、装置及存储介质
EP4445129A1 (en) * 2021-12-07 2024-10-16 Analog Devices International Unlimited Company Sensor assembly and method of manufacture
JP7870529B2 (ja) * 2022-05-20 2026-06-05 国立大学法人豊橋技術科学大学 化学・バイオセンサ素子

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005095938A1 (en) * 2004-04-01 2005-10-13 Nanyang Technological University Addressable transistor chip for conducting assays
US20060199193A1 (en) * 2005-03-04 2006-09-07 Tae-Woong Koo Sensor arrays and nucleic acid sequencing applications
US20070059741A1 (en) * 2005-09-15 2007-03-15 Hitachi, Ltd. Deoxyribonucleic acid measuring apparatus and method of measuring deoxyribonucleic acid
WO2008076406A2 (en) * 2006-12-14 2008-06-26 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes using large scale fet arrays
US20090026082A1 (en) * 2006-12-14 2009-01-29 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes using large scale FET arrays

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6919211B1 (en) 1989-06-07 2005-07-19 Affymetrix, Inc. Polypeptide arrays
FR2805826B1 (fr) 2000-03-01 2002-09-20 Nucleica Nouvelles puces a adn
GB0105831D0 (en) 2001-03-09 2001-04-25 Toumaz Technology Ltd Method for dna sequencing utilising enzyme linked field effect transistors
KR100442838B1 (ko) * 2001-12-11 2004-08-02 삼성전자주식회사 프로브의 고정화 검출방법 및 상기 프로브와 표적시료의결합정도 검출방법
KR100455283B1 (ko) * 2001-04-23 2004-11-08 삼성전자주식회사 물질 유로의 측벽에 형성된 ｍｏｓｆｅｔ으로 이루어진물질 검출용 칩, 이를 포함하는 물질 검출 장치, 이의제조 방법 및 물질 검출 장치를 이용한 물질 검출 방법
WO2005043160A2 (en) * 2003-10-31 2005-05-12 University Of Hawaii Ultrasensitive biochemical sensing platform
US7279588B2 (en) 2003-12-02 2007-10-09 Seoul National University Foundation Dinuclear metal complex and pyrophosphate assay using the same
US20060073422A1 (en) 2004-09-28 2006-04-06 Imation Corp. Portable conformable deep ultraviolet master mask
WO2007002204A2 (en) 2005-06-21 2007-01-04 The Trustees Of Columbia University In The City Of New York Pyrosequencing methods and related compostions
WO2010008480A2 (en) * 2008-06-25 2010-01-21 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes using large scale fet arrays

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005095938A1 (en) * 2004-04-01 2005-10-13 Nanyang Technological University Addressable transistor chip for conducting assays
US20060199193A1 (en) * 2005-03-04 2006-09-07 Tae-Woong Koo Sensor arrays and nucleic acid sequencing applications
US20070059741A1 (en) * 2005-09-15 2007-03-15 Hitachi, Ltd. Deoxyribonucleic acid measuring apparatus and method of measuring deoxyribonucleic acid
WO2008076406A2 (en) * 2006-12-14 2008-06-26 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes using large scale fet arrays
US20090026082A1 (en) * 2006-12-14 2009-01-29 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes using large scale FET arrays

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BAUSELLS J ET AL: "Ion-sensitive field-effect transistors fabricated in a commercial CMOS technology", SENSORS AND ACTUATORS B: CHEMICAL: INTERNATIONAL JOURNAL DEVOTED TO RESEARCH AND DEVELOPMENT OF PHYSICAL AND CHEMICAL TRANSDUCERS, ELSEVIER S.A, CH, vol. 57, no. 1-3, 7 September 1999 (1999-09-07), pages 56 - 62, XP004252985, ISSN: 0925-4005, DOI: 10.1016/S0925-4005(99)00135-5 *
MILGREW M J ET AL: "The development of scalable sensor arrays using standard CMOS technology", SENSORS AND ACTUATORS B: CHEMICAL: INTERNATIONAL JOURNAL DEVOTED TO RESEARCH AND DEVELOPMENT OF PHYSICAL AND CHEMICAL TRANSDUCERS, ELSEVIER S.A, CH, vol. 103, no. 1-2, 29 September 2004 (2004-09-29), pages 37 - 42, XP004560557, ISSN: 0925-4005, DOI: 10.1016/J.SNB.2004.03.004 *

Also Published As

Publication number Publication date
WO2009158006A3 (en) 2010-05-06
EP2304420A2 (en) 2011-04-06
JP2011525990A (ja) 2011-09-29
WO2009158006A2 (en) 2009-12-30
CN102203597A (zh) 2011-09-28
EP3650847A1 (en) 2020-05-13

Similar Documents

Publication Publication Date Title
WO2009158006A3 (en) Methods and apparatus for detecting molecular interactions using fet arrays
WO2010008480A3 (en) Methods and apparatus for measuring analytes using large scale fet arrays
GB2457851A (en) Methods and apparatus for measuring analytes using large scale fet arrays
EP4414690A3 (en) Biosensors for biological or chemical analysis and methods of manufacturing the same
EP1806414A3 (en) Fet-based sensor for detecting ionic material, ionic material detecting device using the fet-based sensor, and method of detecting ionic material using the fet-based sensor
WO2012003368A3 (en) Transistor circuits for detection and measurement of chemical reactions and compounds
TWI317809B (en) System for inline processing of a material
WO2012075445A3 (en) Nanowire field-effect transistor biosensor with improved sensitivity
BRPI0519119A2 (pt) sistema colorimÉtrico e mÉtodo para detectar um analito
BRPI0814201A2 (pt) Sistema e método de análise de produto de análise em amostra fluida e meio legível em computador
WO2012142502A3 (en) Advanced analyte sensor calibration and error detection
WO2010047804A8 (en) Integrated sensor arrays for biological and chemical analysis
GB2458855A (en) Detection device and methods of use
WO2010062627A3 (en) Biosensors based on optical probing and sensing
SA522431594B1 (ar) وسيلة للكشف عن نواتج التحلل في عينة، وطريقة استخدامها
SA519410862B1 (ar) كشاف ذو ضوضاء مدى تفلور منخفضة
WO2009154377A3 (ko) 실시간 연속 검출장치
GB2468097A (en) Process and apparatus for testing a component using an omni-directional eddy current probe
EP2047259A4 (en) BIOSENSOR WITH INTERDIGITAL ELECTRODE SENSORS
BRPI0811536A2 (pt) Detecção de sucinilacetona
SE0800871L (sv) Analysförfarande och anordning
WO2008007065A3 (en) Method and apparatus for measuring activity in the peripheral nervous system
WO2010021521A3 (ko) 탄소나노튜브 기반 바이오센서에서 링커와 스페이서를 이용한 민감도 증가 방법
FR2953292B1 (fr) Capteur d'hydrogene et procede de detection d'une concentration en hydrogene.
WO2007005666A3 (en) System and method of analyte detection using differential receptors

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20110124

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA RS

RIN1 Information on inventor provided before grant (corrected)

Inventor name: ROTHBERG, JONATHAN, M.

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20131002

RIC1 Information provided on ipc code assigned before grant

Ipc: G01N 27/416 20060101ALI20130926BHEP

Ipc: H01L 29/786 20060101ALI20130926BHEP

Ipc: G01N 27/414 20060101AFI20130926BHEP

Ipc: H01L 29/06 20060101ALI20130926BHEP

Ipc: C12Q 1/68 20060101ALI20130926BHEP

17Q First examination report despatched

Effective date: 20160503

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: LIFE TECHNOLOGIES CORPORATION

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

REG Reference to a national code

Ref country code: DE

Ref legal event code: R003

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 20190714