EP2253291A1 - Implant osseux avec une structure d'ancrage en surface - Google Patents
Implant osseux avec une structure d'ancrage en surface Download PDFInfo
- Publication number
- EP2253291A1 EP2253291A1 EP09006746A EP09006746A EP2253291A1 EP 2253291 A1 EP2253291 A1 EP 2253291A1 EP 09006746 A EP09006746 A EP 09006746A EP 09006746 A EP09006746 A EP 09006746A EP 2253291 A1 EP2253291 A1 EP 2253291A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- bone
- bone implant
- implant
- core
- claw
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
- A61F2/36—Femoral heads ; Femoral endoprostheses
- A61F2/3662—Femoral shafts
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/02—Prostheses implantable into the body
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- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
- A61F2002/30011—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in porosity
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/02—Prostheses implantable into the body
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2002/4681—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor by applying mechanical shocks, e.g. by hammering
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- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
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- A61F2230/0017—Angular shapes
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- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0028—Shapes in the form of latin or greek characters
- A61F2230/0058—X-shaped
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- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
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- A—HUMAN NECESSITIES
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- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0023—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in porosity
- A61F2250/0024—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in porosity made from both porous and non-porous parts, e.g. adjacent parts
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- A—HUMAN NECESSITIES
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- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0026—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in surface structures
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- A—HUMAN NECESSITIES
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- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
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- A—HUMAN NECESSITIES
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- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00029—Cobalt-based alloys, e.g. Co-Cr alloys or Vitallium
Definitions
- This invention relates to a bone implant having a surface structure for anchoring the implant to a bone without the use of cement.
- Primary fixation refers to the fixation of an implant during the initial period after insertion by the surgeon (first few weeks). During this period it is desirable that micromotions of the implant relative to the host bone are minimised so that growth of hard bone tissue into the pores of the implant is promoted. If there is excessive micromotion, then fibrous tissue tends to develop instead of hard bone resulting in poor fixation of the implant [Engh et al., Clinical Orthopaedics and Related Research, 1992].
- Secondary fixation refers to the long-term fixation of the implant, following the initial primary fixation period. During this period, it is desirable for hard bone to grow into the pores of the implant and firmly fix it in place relative to the host bone. If there is poor primary fixation, then it will not be possible to achieve good secondary fixation [Abdul-Kadir et al., J. Biomechanics, 2008].
- the coating must be applied to the core in a separate manufacturing step, resulting in increased cost and the risk of debonding from the core [Hollister, Current Orthopaedics, 1995, Hamilton et al., J. Arthroplasty, 2007 ].
- US7018418 describes a textured surface for medical implants having micro recesses such that the outer surface overhangs the micro recesses.
- Embodiments of the textured surface include sharp edges for promoting bone deposition and growth within the micro recesses, protrusions of varying depth from the surface that include overhangs, and micro recesses that are at least partially defined by complex ellipsoids.
- US4272855 describes an anchoring surface of a bone implant provided with villi (depressions or projections) devoid of corners and edges.
- the villi are of generally conical shape with transition surfaces merging into the base level of the anchoring surface.
- the villi allow implanting in a bone without cement since bone tissue is allowed to grow into or around the villi.
- US2007/0142914 describes a method of forming an implant having a porous tissue ingrowth structure and a bearing support structure. The method includes depositing a first layer of a metal powder onto a substrate, scanning a laser beam over the powder so as to sinter the metal powder at predetermined locations, depositing at least one layer of the metal powder onto the first layer and repeating the scanning of the laser beam.
- a bone implant comprising a core having an integral anchoring structure at its surface, the structure comprising an array of mutually spaced pointed teeth for digging into bone to which the implant is to be attached, and a network of pores underlying the array and communicating with the exterior of the surface via openings between the teeth, the pores allowing for the circulation of nutrients to promote bone growth.
- the structure of the device provides for both primary and secondary fixation of the implant.
- the openings between the teeth allow growth of bone into the network of pores.
- the pointed teeth extend upwardly from said core.
- the network of pores are substantially fully interconnected.
- upwardly means in a direction generally away from the underlying implant core, and "substantially fully interconnected” means that there is a continuous pathway between substantially every pore in the structure. As the pores are interconnected, this allows for free movement of the appropriate cells and nutrients to promote bone in-growth.
- each tooth forms an overhang and is generally in the form of a claw.
- the implant may be manufactured from any suitable material (for example titanium, titanium alloys, cobalt-chromium or other biocompatible metallic material), in a rapid prototyping process using, for example, selective laser sintering, which integrates the surface structure with the solid core.
- suitable material for example titanium, titanium alloys, cobalt-chromium or other biocompatible metallic material
- FIGS. 1-10 show the anchoring structure as a flat, circular disc, it will be understood that in a practical implementation the structure will be shaped and dimensioned to conform to the contours of a particular bone implant to which it is applied. Also, in Figures 1 to 10 , only the outermost layer of the implant's core is shown.
- a cementless bone implant comprises a solid core 10 having an integral anchoring structure 12 at its surface.
- the anchoring structure 12 comprises a two dimensional array of upwardly extending mutually spaced pointed teeth 14 for digging into bone to which the implant is to be attached, and a substantially fully interconnected network of pores 16 underlying the array and communicating with the exterior of the surface via openings 18 between the teeth 12.
- the anchoring structure 12 is built up integrally with the core 10 by a rapid prototyping process such as direct metal laser sintering (DMLS) or electron beam melting.
- DMLS direct metal laser sintering
- the anchoring structure and core are made of titanium, titanium alloy, cobalt-chromium or other biocompatible metal material.
- each tooth 12 forms an overhang 20, Figure 4 , so that it is generally in the form of a claw.
- Each claw 12 has a substantially triangular upper surface 22 with convergent edges 24 defining a point 26 at the free end of the claw.
- the upper surface 22 is substantially parallel to the underlying core 10, but, as will be described, the upper surface 22 may be inclined upwardly to the point 26.
- the teeth 12 may extend directly upwards without any overhang 20 and terminate in a point.
- the anchoring structure 12 may comprise alternative claw shapes, for example a wedge-shaped claw.
- the claws 12 Over substantial areas of the implant the claws 12 have a common orientation; for example, in the representative part of the implant shown in Figure 2 , all the claws point towards the right. However, dependent on the design of the particular implant, different areas of the structure may have the claws 12 pointing in different directions respectively. This is to allow the most advantageous attachment to the bone in different areas of the implant. It will be understood that the repeating pattern of the claws may be varied to give optimum primary fixation of the implant to the host bone.
- the structure 12 is actually constructed as a grid of intersecting struts 28 supported above the core 10 by a plurality of pillars 30 intersecting the grid at the intersections of the struts and extending upwardly beyond the strut intersection to form the claws 14.
- the junctions between the intersecting struts and pillars, and between the pillars and underlying core are filleted as indicated schematically by the dashed lines 32. It should be understood that the fillets 32 are not applied subsequent to the manufacture of the grid 28 and columns 30, but are formed integrally during the manufacture by, for example, selective laser sintering.
- the fillets have been designed to reduce stress concentrations in order to withstand the extreme case loading and fatigue loading conditions that are experienced in-vivo. It will be also be understood that there may be more than one layer in depth of interconnecting struts, i.e. that there could be a 3D lattice of interconnecting struts and pillars, between the outer surface of the implant base 10 and the claws 14.
- Figure 6 and 7 are views similar to Figures 3 and 4 in which certain dimensions of the structure 12, listed in the first column of the following table, are indicated by the numerals 1 to 12: Structure Dimension Embodiment (mm) Preferred Range (mm) 1 1.4 0.7 - 3.0 2 1.4 0.7 - 3.0 3 0.04 0 - 0.2 (radius) 4 0.7 0.1 - 3.0 5 0.09 0 - 3.0 (radius) 6 0.64 0.1 - 3.0 7 0.61 0.1 - 3.0 8 0.7 0.1 - 3.0 9 0.5 0.1 - 2.0 10 0.25 0 - 2.0 11 (°) 0 0 - 90 12 1.05 0.1 - 3.0
- the second column lists the values of these dimensions for the particular embodiment of Figures 1 to 5
- the third column lists the preferred ranges for these dimensions for all embodiments.
- dimension (10) gives the offset of the upper surface of the claw, i.e. the distance between the centre line of the pillar and the centre of the top surface of the claw
- dimension (12) gives the distance from the surface of the core to the centreline of the intersecting struts.
- the radius of the intersecting struts are given in dimensions (4) and (8).
- the angle 11 was 0 degrees. In a second preferred embodiment the angle 11 is 10 degrees, as shown in Figures 8 and 9 which are views similar to Figures 3 and 4 respectively.
- FIG 10 illustrates the successive steps in attaching the implant to a patient's bone 34.
- step (a) the implant is pushed onto the bone in the direction indicated by the arrow, and then hammered in place by the surgeon, steps (b) to (d), so that the claws 14 dig into the bone 34.
- steps (b) to (d) This is the primary fixation, and no cement need be used (although the additional use of cement is not ruled out).
- the claws are designed to prevent micromotions of the implant during the primary fixation period to avoid the development of fibrous tissue.
- Steps (e) and (f) show the gradual long term bone growth into the wells between claws 14 and into the network of pores. This is the secondary fixation.
- FIG. 11 shows a total hip replacement stem (THRS) embodying the invention.
- Fig. 11(a) shows a CAD model (A) of the stem, as well as an image of a manufactured stem model (B).
- Fig. 11(b) shows an enlarged view of the anchoring structure architecture adjacent the distal end of the implant stem.
- the anchoring structure 12 is formed substantially the entire length of the stem body except for the ball joint. It will also be understood that the anchoring structure may be provided on a portion of the stem of the implant.
- the THRS incorporates the novel surface anchoring structure 12 described above, designed to encourage bone growth into the stem and to resist in-vivo mechanical loading conditions.
- the stem is manufactured from titanium in a 1-step rapid prototyping (RP) process which integrates the surface architecture with the solid core.
- the anchoring structure includes the network of interconnected pores 16 whose dimensions are chosen to give the maximum potential for bone in-growth. The pore junctions are filleted in order to reduce the stresses developed under in-vivo loading conditions.
- Initial cell culture tests where bone-type cells were seeded onto coupons with the surface architecture and coupons from commercially available stems, showed that cell proliferation occurs in the new surface architecture, indicating the potential of the new design to provide better bone in-growth compared to existing products on the market. This may result in an increased operational lifetime of the THRS in-vivo, a reduction in required revision operations and, consequently, a marked improvement in patient well-being.
- the THRS anchoring structure also includes the claw-like teeth 14 on the external surface of the interconnected pore network which is designed to provide improved primary fixation of the stem immediately after implantation.
- Primary fixation has been shown to be critical for achieving in-growth of hard bone tissue, since micro-motions of the stem relative to the femur after implantation tend to result in undesirable fibrous tissue instead of hard bone.
Landscapes
- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL09006746.3T PL2253291T3 (pl) | 2009-05-19 | 2009-05-19 | Implant kostny ze strukturą mocującą na powierzchni |
EP09006746.3A EP2253291B1 (fr) | 2009-05-19 | 2009-05-19 | Implant osseux avec une structure d'ancrage en surface |
DK09006746.3T DK2253291T3 (en) | 2009-05-19 | 2009-05-19 | The bone implants with a structure overfladeforankrende |
JP2010114585A JP2010269144A (ja) | 2009-05-19 | 2010-05-18 | 表面固定構造を有する骨インプラント |
CN2010101857413A CN101889911A (zh) | 2009-05-19 | 2010-05-19 | 带有表面锚定结构的骨骼植入件 |
US12/783,025 US8888862B2 (en) | 2009-05-19 | 2010-05-19 | Bone implant with a surface anchoring structure |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09006746.3A EP2253291B1 (fr) | 2009-05-19 | 2009-05-19 | Implant osseux avec une structure d'ancrage en surface |
Publications (2)
Publication Number | Publication Date |
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EP2253291A1 true EP2253291A1 (fr) | 2010-11-24 |
EP2253291B1 EP2253291B1 (fr) | 2016-03-16 |
Family
ID=41129337
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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EP09006746.3A Active EP2253291B1 (fr) | 2009-05-19 | 2009-05-19 | Implant osseux avec une structure d'ancrage en surface |
Country Status (6)
Country | Link |
---|---|
US (1) | US8888862B2 (fr) |
EP (1) | EP2253291B1 (fr) |
JP (1) | JP2010269144A (fr) |
CN (1) | CN101889911A (fr) |
DK (1) | DK2253291T3 (fr) |
PL (1) | PL2253291T3 (fr) |
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ITMO20110115A1 (it) * | 2011-05-16 | 2012-11-17 | Caselli Stefano | Supporto osteoinduttivo |
US20130211534A1 (en) * | 2010-04-29 | 2013-08-15 | Finsbury (Development) Limited | Prosthesis |
FR2986962A1 (fr) * | 2012-02-20 | 2013-08-23 | Pierre-Etienne Moreau | Cupule pour implant orthopedique, implant orthopedique comprenant une telle cupule et procede pour realiser une telle cupule |
EP3174486A4 (fr) * | 2014-07-28 | 2018-04-04 | Warsaw Orthopedic, Inc. | Système et méthode pour implant rachidien |
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US11324606B2 (en) | 2017-03-10 | 2022-05-10 | Gary A. Zwick | Spinal interbody cage comprising a bulk interbody cage, a top face, a bottom face, pillars, and slots |
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ATE287307T1 (de) | 2002-11-08 | 2005-02-15 | Howmedica Osteonics Corp | Lasererzeugte poröse oberfläche |
US20060147332A1 (en) | 2004-12-30 | 2006-07-06 | Howmedica Osteonics Corp. | Laser-produced porous structure |
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US8430930B2 (en) | 2008-12-18 | 2013-04-30 | 4-Web, Inc. | Truss implant |
US20130030529A1 (en) * | 2011-07-29 | 2013-01-31 | Jessee Hunt | Implant interface system and method |
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US10154913B2 (en) | 2012-06-21 | 2018-12-18 | Renovis Surgical Technologies, Inc. | Surgical implant devices incorporating porous surfaces and a locking plate |
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US9415137B2 (en) * | 2012-08-22 | 2016-08-16 | Biomet Manufacturing, Llc. | Directional porous coating |
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JP6419181B2 (ja) * | 2013-07-24 | 2018-11-07 | レノビス サージカル テクノロジーズ,インコーポレイテッド | 多孔質表層を組み込んでいる外科用インプラント装置 |
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US20130211534A1 (en) * | 2010-04-29 | 2013-08-15 | Finsbury (Development) Limited | Prosthesis |
EP2579817B1 (fr) | 2010-06-08 | 2022-08-31 | Smith & Nephew, Inc. | Composants d'implant et procédés |
ITMO20110115A1 (it) * | 2011-05-16 | 2012-11-17 | Caselli Stefano | Supporto osteoinduttivo |
FR2986962A1 (fr) * | 2012-02-20 | 2013-08-23 | Pierre-Etienne Moreau | Cupule pour implant orthopedique, implant orthopedique comprenant une telle cupule et procede pour realiser une telle cupule |
WO2013124576A1 (fr) * | 2012-02-20 | 2013-08-29 | Galactic | Cupule pour implant orthopedique, implant orthopedique comprenant une telle cupule et procede pour realiser une telle cupule |
EP3174486A4 (fr) * | 2014-07-28 | 2018-04-04 | Warsaw Orthopedic, Inc. | Système et méthode pour implant rachidien |
US11324606B2 (en) | 2017-03-10 | 2022-05-10 | Gary A. Zwick | Spinal interbody cage comprising a bulk interbody cage, a top face, a bottom face, pillars, and slots |
US11696831B2 (en) | 2017-03-10 | 2023-07-11 | Alps Holding Llc | Hard-tissue implant comprising a bulk implant, a face, pillars, slots, and at least one support member |
EP3773348A4 (fr) * | 2018-04-10 | 2022-01-19 | Gary A. Zwick, Trustee of the Everest Trust UTA April 20, 2017 | Cage intersomatique vertébrale comprenant des faces supérieure et inférieure avec des structures maillées, des piliers et des fentes |
US11278427B2 (en) | 2018-04-10 | 2022-03-22 | Gary A. Zick, Trustee Of The Everest Trust Uta April 20, 2017 | Spinal interbody cage comprising top and bottom faces with mesh structures, pillars and slots |
CN112155798A (zh) * | 2020-10-30 | 2021-01-01 | 嘉思特华剑医疗器材(天津)有限公司 | 钛合金分区骨小梁股骨柄及制备方法 |
CN112155798B (zh) * | 2020-10-30 | 2024-04-09 | 嘉思特华剑医疗器材(天津)有限公司 | 钛合金分区骨小梁股骨柄及制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN101889911A (zh) | 2010-11-24 |
DK2253291T3 (en) | 2016-06-13 |
PL2253291T3 (pl) | 2016-09-30 |
EP2253291B1 (fr) | 2016-03-16 |
JP2010269144A (ja) | 2010-12-02 |
US8888862B2 (en) | 2014-11-18 |
US20100298950A1 (en) | 2010-11-25 |
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