EP2190421A2 - Inhibiteurs 17bêta-hydroxystéroïd-déhydrogénase de type 1 pour traiter des maladies hormono-dépendantes - Google Patents
Inhibiteurs 17bêta-hydroxystéroïd-déhydrogénase de type 1 pour traiter des maladies hormono-dépendantesInfo
- Publication number
- EP2190421A2 EP2190421A2 EP08787432A EP08787432A EP2190421A2 EP 2190421 A2 EP2190421 A2 EP 2190421A2 EP 08787432 A EP08787432 A EP 08787432A EP 08787432 A EP08787432 A EP 08787432A EP 2190421 A2 EP2190421 A2 EP 2190421A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- hydroxyphenyl
- harom
- phenol
- nmr
- mhz
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 239000005556 hormone Substances 0.000 title claims abstract description 18
- 238000011282 treatment Methods 0.000 title claims description 19
- 239000003112 inhibitor Substances 0.000 title abstract description 40
- 102100037426 17-beta-hydroxysteroid dehydrogenase type 1 Human genes 0.000 title abstract description 22
- 101710147298 17-beta-hydroxysteroid dehydrogenase type 1 Proteins 0.000 title abstract description 5
- 101710174215 Estradiol 17-beta-dehydrogenase 1 Proteins 0.000 title abstract description 5
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 24
- 150000003254 radicals Chemical class 0.000 claims description 22
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 12
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- ITUNDPZWPPYDKV-UHFFFAOYSA-N 3-[1-(4-hydroxyphenyl)imidazol-4-yl]phenol Chemical compound C1=CC(O)=CC=C1N1C=C(C=2C=C(O)C=CC=2)N=C1 ITUNDPZWPPYDKV-UHFFFAOYSA-N 0.000 claims description 9
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- WSUUHCNQLBCNOV-UHFFFAOYSA-N 3-[2-(3-hydroxyphenyl)-1,3-thiazol-4-yl]phenol Chemical compound OC1=CC=CC(C=2N=C(SC=2)C=2C=C(O)C=CC=2)=C1 WSUUHCNQLBCNOV-UHFFFAOYSA-N 0.000 claims description 6
- OYFRXCWZMBHNHW-UHFFFAOYSA-N 3-[2-(3-hydroxyphenyl)-1,3-thiazol-5-yl]phenol Chemical compound OC1=CC=CC(C=2SC(=NC=2)C=2C=C(O)C=CC=2)=C1 OYFRXCWZMBHNHW-UHFFFAOYSA-N 0.000 claims description 6
- ROVOGSGRLVCJAM-UHFFFAOYSA-N 3-[4-(4-hydroxyphenyl)-1,3-thiazol-2-yl]phenol Chemical compound C1=CC(O)=CC=C1C1=CSC(C=2C=C(O)C=CC=2)=N1 ROVOGSGRLVCJAM-UHFFFAOYSA-N 0.000 claims description 6
- SVBBCXVMACPXGW-UHFFFAOYSA-N 3-[5-(3-hydroxyphenyl)thiophen-2-yl]phenol Chemical compound OC1=CC=CC(C=2SC(=CC=2)C=2C=C(O)C=CC=2)=C1 SVBBCXVMACPXGW-UHFFFAOYSA-N 0.000 claims description 6
- QWBAQAYKEITCRE-UHFFFAOYSA-N 3-[5-(4-hydroxyphenyl)-1,3-oxazol-2-yl]phenol Chemical compound C1=CC(O)=CC=C1C1=CN=C(C=2C=C(O)C=CC=2)O1 QWBAQAYKEITCRE-UHFFFAOYSA-N 0.000 claims description 6
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- 125000005843 halogen group Chemical group 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
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Abstract
L'invention concerne des inhibiteurs 17bêta-hydroxystéroïd-déhydrogénase de type 1 (17bêtaHSD1), leur production et leur utilisation pour le traitement prophylactique et thérapeutique de maladies hormono-dépendantes, notamment de maladies dépendant d'oestrogènes ou d'androgènes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102007040243A DE102007040243A1 (de) | 2007-08-25 | 2007-08-25 | 17Beta-Hydroxysteriod-Dehydrogenase Typ1 Inhibitoren zur Behandlung hormonabhängiger Erkrankungen |
PCT/EP2008/061033 WO2009027346A2 (fr) | 2007-08-25 | 2008-08-22 | Inhibiteurs 17bêta-hydroxystéroïd-déhydrogénase de type 1 pour traiter des maladies hormono-dépendantes |
Publications (1)
Publication Number | Publication Date |
---|---|
EP2190421A2 true EP2190421A2 (fr) | 2010-06-02 |
Family
ID=39929888
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP08787432A Withdrawn EP2190421A2 (fr) | 2007-08-25 | 2008-08-22 | Inhibiteurs 17bêta-hydroxystéroïd-déhydrogénase de type 1 pour traiter des maladies hormono-dépendantes |
Country Status (6)
Country | Link |
---|---|
US (1) | US20110046147A1 (fr) |
EP (1) | EP2190421A2 (fr) |
JP (1) | JP2010536922A (fr) |
CA (1) | CA2697827A1 (fr) |
DE (1) | DE102007040243A1 (fr) |
WO (1) | WO2009027346A2 (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9187485B2 (en) | 2007-02-02 | 2015-11-17 | Baylor College Of Medicine | Methods and compositions for the treatment of cancer and related hyperproliferative disorders |
WO2010099853A1 (fr) * | 2009-02-19 | 2010-09-10 | Merck Patent Gmbh | Dérivés de thiophène et milieux de cristaux liquides les contenant |
WO2012118935A1 (fr) | 2011-03-03 | 2012-09-07 | Proteotech Inc | Composés pour le traitement de maladies neurodégénératives |
ES2489815B1 (es) | 2013-02-21 | 2015-08-10 | Centro De Investigación Príncipe Felipe | Nuevos p-terfenilos hexakis-sustituidos con grupos bilaterales para el tratamiento de la infección por el virus de la inmunodeficiencia humana tipo 1 (VIH-1) y otras enfermedades |
WO2015031710A1 (fr) * | 2013-08-29 | 2015-03-05 | Baylor College Of Medicine | Compositions et procédés de traitement de troubles métaboliques et troubles associés au poids corporel |
EP3089969A2 (fr) | 2014-01-03 | 2016-11-09 | Elexopharm GmbH | Inhibiteurs des 17bêta-hydroxystéroïde déshydrogénases de type 1 et 2 |
BR112016018691A2 (pt) | 2014-02-14 | 2017-08-08 | Univ British Columbia | Compostos do domínio de ligação ao dna (dbd) de receptor de andrógeno humano como terapêuticos e métodos para seu uso |
JPWO2015166862A1 (ja) * | 2014-04-30 | 2017-04-20 | 日本カーバイド工業株式会社 | ビスピラゾール化合物を製造する方法 |
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2007
- 2007-08-25 DE DE102007040243A patent/DE102007040243A1/de not_active Ceased
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- 2008-08-22 US US12/675,065 patent/US20110046147A1/en not_active Abandoned
- 2008-08-22 JP JP2010522332A patent/JP2010536922A/ja active Pending
- 2008-08-22 WO PCT/EP2008/061033 patent/WO2009027346A2/fr active Application Filing
- 2008-08-22 CA CA2697827A patent/CA2697827A1/fr not_active Abandoned
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US20110046147A1 (en) | 2011-02-24 |
JP2010536922A (ja) | 2010-12-02 |
WO2009027346A3 (fr) | 2009-05-28 |
WO2009027346A2 (fr) | 2009-03-05 |
CA2697827A1 (fr) | 2009-03-05 |
DE102007040243A1 (de) | 2009-02-26 |
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