TW200720254A - Use of 3,5-diphenyl pyrazole derivatives as anti-tumor agent - Google Patents

Use of 3,5-diphenyl pyrazole derivatives as anti-tumor agent

Info

Publication number
TW200720254A
TW200720254A TW095111919A TW95111919A TW200720254A TW 200720254 A TW200720254 A TW 200720254A TW 095111919 A TW095111919 A TW 095111919A TW 95111919 A TW95111919 A TW 95111919A TW 200720254 A TW200720254 A TW 200720254A
Authority
TW
Taiwan
Prior art keywords
group
hydrogen atom
malignant tumor
substituents
halo
Prior art date
Application number
TW095111919A
Other languages
Chinese (zh)
Inventor
Shunsuke Kuroiwa
Sakiko Maruyama
Yoshikazu Suzuki
Hiroko Yamazaki
Original Assignee
Nippon Kayaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Kk filed Critical Nippon Kayaku Kk
Publication of TW200720254A publication Critical patent/TW200720254A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

It is desired to develop an anti-tumor agent having excellent anti-tumor effect for malignant tumor. This invention provides a 3,5-diphenyl pyrazole derivative or pharmaceutically acceptable salts thereof, represented by following formula (1) as effective ingredient in a proliferative inhibiting agent for malignant tumor. To provided a 3,5-diphenyl pyrazole derivative or physiologically acceptable salts, [in formula, group A represents a hydrogen atom, carbonyl or sulfonyl (tautomers are included when group A is a hydrogen atom); group J represents a lower alkyl optionally having substituents, or amino optionally having substituents; group G and Z each independently represent a hydrogen atom, hydroxyl, lower alkoxy, halo, or acyloxy optionally having substituents (provided one of group G and Z is a hydrogen atom or halo, or one of group G and Z is a hydrogen atom, another one is not a halo), group D, E, L, Q, X and Y each independently represent a hydrogen atom, amino-carbonyl optionally having substituents, lower alkoxy-carbonyl, carboxyl, nitryl, nitro, halo, lower alkyl, halo substituted-lower alkyl, lower alkoxy, lower alkylthio, lower alkyl-sulfoxyl, lower alkyl-sulfone, or amino-sulfonyl optionally having substituents; both group D and group L and/or both group Q and group Y may be together with atoms (up to 2) independently selected from nitrogen atom, oxygen atom or sulfur atom to form a hetero ring having a 5- to 6-membered ring], as effective ingredient for inhibiting method of proliferation for malignant tumor, proliferative inhibition agent for malignant tumor, especially a method for malignant tumor shrinkage and shrinkage agent for malignant tumor.
TW095111919A 2005-04-07 2006-04-04 Use of 3,5-diphenyl pyrazole derivatives as anti-tumor agent TW200720254A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2005110717 2005-04-07

Publications (1)

Publication Number Publication Date
TW200720254A true TW200720254A (en) 2007-06-01

Family

ID=37086955

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095111919A TW200720254A (en) 2005-04-07 2006-04-04 Use of 3,5-diphenyl pyrazole derivatives as anti-tumor agent

Country Status (2)

Country Link
TW (1) TW200720254A (en)
WO (1) WO2006109680A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007040243A1 (en) * 2007-08-25 2009-02-26 Universität des Saarlandes 17beta-hydroxysteriod dehydrogenase type 1 inhibitors for the treatment of hormone-dependent diseases
CA2726999C (en) * 2008-06-09 2017-05-02 Ludwig-Maximilians-Universitaet Muenchen New drugs for inhibiting aggregation of proteins involved in diseases linked to protein aggregation and/or neurodegenerative diseases
US9493439B1 (en) * 2014-04-07 2016-11-15 University Of Kentucky Research Foundation Proteasome inhibitors
CN112457255B (en) * 2017-11-08 2022-08-19 北京嘉林药业股份有限公司 Compounds and their use for treating cancer
CN110437220B (en) * 2018-07-13 2022-12-27 暨南大学 Triazole compound and application thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3903993A1 (en) * 1989-02-10 1990-08-16 Basf Ag DIARYL SUBSTITUTED HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND MEDICINAL PRODUCTS THEREOF
DE69935335T2 (en) * 1998-08-07 2007-11-22 Novartis Vaccines and Diagnostics, Inc., Emeryville PYRAZOLE AS MODULATORS OF THE ESTROGEN RECEPTOR
US20040010027A1 (en) * 2001-12-17 2004-01-15 Pharmacia & Upjohn Spa Hydroxphenyl-pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical comositions comprising them
EP1398029A1 (en) * 2002-09-10 2004-03-17 LION Bioscience AG NR3B1 nuclear receptor binding 3-substituted pyrazole derivatives
EP1601657A1 (en) * 2003-03-12 2005-12-07 Vertex Pharmaceuticals Incorporated Pyrazole modulators of atp-binding cassette transporters
EP1773330B1 (en) * 2004-07-22 2010-05-26 Merck Sharp & Dohme Corp. Substituted pyrazoles, compositions containing such compounds and methods of use

Also Published As

Publication number Publication date
WO2006109680A1 (en) 2006-10-19

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