EP2187893A4 - Kleine boronhaltige moleküle als entzündungshemmende wirkstoffe - Google Patents

Kleine boronhaltige moleküle als entzündungshemmende wirkstoffe

Info

Publication number
EP2187893A4
EP2187893A4 EP09700012A EP09700012A EP2187893A4 EP 2187893 A4 EP2187893 A4 EP 2187893A4 EP 09700012 A EP09700012 A EP 09700012A EP 09700012 A EP09700012 A EP 09700012A EP 2187893 A4 EP2187893 A4 EP 2187893A4
Authority
EP
European Patent Office
Prior art keywords
boron
small molecules
inflammatory agents
containing small
inflammatory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09700012A
Other languages
English (en)
French (fr)
Other versions
EP2187893A2 (de
Inventor
Tsutomu Akama
Yong-Kang Zhang
Charles Z Ding
Jacob J Plattner
Kirk R Maples
Yvonne Freund
Virginia Sanders
Yi Xia
Stephen J Baker
James A Niemann
Xiaosong Lu
Marcelo Sales
Rashmi Sharma
Rajeshwar Singh
Robert Jacobs
Daitao Chen
Michael Richard Kevin Alley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anacor Pharmaceuticals Inc
Original Assignee
Anacor Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anacor Pharmaceuticals Inc filed Critical Anacor Pharmaceuticals Inc
Priority to EP17158536.7A priority Critical patent/EP3246034A1/de
Priority to EP12178640.4A priority patent/EP2564857B1/de
Publication of EP2187893A2 publication Critical patent/EP2187893A2/de
Publication of EP2187893A4 publication Critical patent/EP2187893A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP09700012A 2008-03-06 2009-03-05 Kleine boronhaltige moleküle als entzündungshemmende wirkstoffe Withdrawn EP2187893A4 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP17158536.7A EP3246034A1 (de) 2008-03-06 2009-03-05 Boronhaltige kleinmoleküle als entzündungshemmende wirkstoffe
EP12178640.4A EP2564857B1 (de) 2008-03-06 2009-03-05 Boronhaltige Kleinmoleküle als entzündungshemmende Wirkstoffe

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US3437108P 2008-03-06 2008-03-06
US5263708P 2008-05-12 2008-05-12
US9440608P 2008-09-04 2008-09-04
US10599008P 2008-10-16 2008-10-16
US11090308P 2008-11-03 2008-11-03
US14370009P 2009-01-09 2009-01-09
US14873109P 2009-01-30 2009-01-30
PCT/US2009/036250 WO2009111676A2 (en) 2008-03-06 2009-03-05 Boron-containing small molecules as anti-inflammatory agents

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP17158536.7A Division EP3246034A1 (de) 2008-03-06 2009-03-05 Boronhaltige kleinmoleküle als entzündungshemmende wirkstoffe
EP12178640.4A Division EP2564857B1 (de) 2008-03-06 2009-03-05 Boronhaltige Kleinmoleküle als entzündungshemmende Wirkstoffe

Publications (2)

Publication Number Publication Date
EP2187893A2 EP2187893A2 (de) 2010-05-26
EP2187893A4 true EP2187893A4 (de) 2012-02-22

Family

ID=41056660

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09700012A Withdrawn EP2187893A4 (de) 2008-03-06 2009-03-05 Kleine boronhaltige moleküle als entzündungshemmende wirkstoffe

Country Status (2)

Country Link
EP (1) EP2187893A4 (de)
WO (1) WO2009111676A2 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2987796T3 (pl) 2005-02-16 2018-12-31 Anacor Pharmaceuticals, Inc. Fluorowco-podstawione boronoftalidy do leczenia zakażeń
RU2008131324A (ru) 2005-12-30 2010-02-10 Анакор Фармасьютикалз, Инк. (Us) Борсодержащие малые молекулы
PL1988779T3 (pl) 2006-02-16 2015-10-30 Anacor Pharmaceuticals Inc Małe cząsteczki zawierające bor jako środki przeciwzapalne
ES2630036T3 (es) 2008-03-06 2017-08-17 Anacor Pharmaceuticals, Inc. Moléculas pequeñas que contienen boro como agentes antiinflamatorios
EP2348863A4 (de) 2008-09-04 2012-03-07 Anacor Pharmaceuticals Inc Borhaltige kleine moleküle
WO2010028005A1 (en) 2008-09-04 2010-03-11 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2010045503A1 (en) 2008-10-15 2010-04-22 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-protozoal agents
SG172040A1 (en) 2008-12-17 2011-07-28 Anacor Pharmaceuticals Inc Polymorphs of (s)-3-aminomethyl-7-(3-hydroxy-propoxy)-3h-benzo[c][1,2] oxaborol-1-ol
JP2013500974A (ja) 2009-07-28 2013-01-10 アナコール ファーマシューティカルズ，インコーポレイテッド 三置換ホウ素含有分子
AP4039A (en) 2009-08-14 2017-02-28 Daitao Chen Boron-containing small molecules as antiprotozoal agents
WO2011022337A1 (en) 2009-08-19 2011-02-24 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
WO2011049971A1 (en) 2009-10-20 2011-04-28 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
WO2011060196A1 (en) 2009-11-11 2011-05-19 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2011063293A1 (en) * 2009-11-20 2011-05-26 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antihelminth agents
US8716478B2 (en) * 2010-01-27 2014-05-06 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2011116348A1 (en) 2010-03-19 2011-09-22 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-protozoal agent
CN108610356B (zh) 2010-09-07 2021-02-26 阿纳科制药公司 苯并氧杂硼杂环戊二烯衍生物用于治疗细菌感染
JP6367712B2 (ja) 2011-08-19 2018-08-01 グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ Ｃ型肝炎ウイルス感染の治療のためのベンゾフラン化合物
US9585396B2 (en) 2013-01-30 2017-03-07 Agrofresh Inc. Volatile applications against pathogens
US11039617B2 (en) 2013-01-30 2021-06-22 Agrofresh Inc. Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness
US10070649B2 (en) 2013-01-30 2018-09-11 Agrofresh Inc. Volatile applications against pathogens
US8669207B1 (en) 2013-01-30 2014-03-11 Dow Agrosciences, Llc. Compounds and compositions
AR094666A1 (es) 2013-01-30 2015-08-19 Dow Agrosciences Llc Uso de benzoxaborolas como agentes antimicrobianos volátiles en carnes, plantas o partes de plantas
KR20170024068A (ko) 2014-07-01 2017-03-06 다이이찌 산쿄 가부시키가이샤 항박테리아제로서의 삼환식 벤즈옥사보롤
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
ES2858311T3 (es) 2015-11-30 2021-09-30 Anacor Pharmaceuticals Inc Formulaciones farmacéuticas tópicas para el tratamiento de afecciones relacionadas con inflamación
RS64770B1 (sr) 2016-03-07 2023-11-30 Agrofresh Inc Sinergistički postupci upotrebe jedinjenja benzoksaborola i gasova za prezerviranje kao antimikrobnih agenasa za useve
US11447506B2 (en) 2016-05-09 2022-09-20 Anacor Pharmaceuticals, Inc. Crystal forms of crisaborole in free form and preparation method and use thereof
WO2017203514A1 (en) * 2016-05-26 2017-11-30 Perrigo Api Ltd Polymorphs of crisaborole and production processes therefor
EP3609504A4 (de) 2017-03-01 2021-03-03 Anacor Pharmaceuticals, Inc. Neuartige oxaborolanaloga und verwendungen davon
US10981939B2 (en) 2017-05-12 2021-04-20 Biophore India Pharmaceuticals Pvt. Ltd. Process for the preparation of 4-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl) oxy] benzonitrile (Crisaborole)
US10865217B2 (en) 2017-05-23 2020-12-15 Msn Laboratories Private Limited, R & D Center Process for the preparation of 5-(4-cyanophenoxy)-1,3-dihydro-1-hydroxy-[2,1]-benzoxaborole and polymorphs thereof
WO2019108982A1 (en) 2017-11-30 2019-06-06 Boragen, Inc. Benzoxaborole compounds and formulations thereof
CA3148168A1 (en) 2018-08-18 2020-02-27 Chun Yu Liu Solid forms of substituted benzoxaborole and compositions thereof
SG11202102674RA (en) 2018-10-05 2021-04-29 Pfizer Boron containing pde4 inhibitors
EP3936192A4 (de) 2019-03-06 2022-11-16 Daiichi Sankyo Company, Limited Pyrrolopyrazolderivate
CN112174989B (zh) * 2019-07-02 2023-06-20 江西同和药业股份有限公司 一种克立硼罗的制备方法
WO2022043936A1 (en) 2020-08-31 2022-03-03 Pfizer Inc. Methods of protecting rna
WO2024038090A1 (en) * 2022-08-18 2024-02-22 Mitodicure Gmbh Use of substituted benzoxazole and benzofuran compounds for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance
CN116239498B (zh) * 2023-05-11 2023-07-21 北京元延医药科技股份有限公司 制备克立硼罗中间体的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060234981A1 (en) * 2005-02-16 2006-10-19 Anacor Pharmaceuticals Boron-containing small molecules

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6596985B2 (en) * 2000-02-22 2003-07-22 Rioch Company, Ltd. Multi-beam scanning device, multi-beam scanning method, light source device, and image forming apparatus
PE20061303A1 (es) * 2005-03-30 2006-12-07 Astion Dev As Composicion farmaceutica que comprende oxaprozina
PL1988779T3 (pl) * 2006-02-16 2015-10-30 Anacor Pharmaceuticals Inc Małe cząsteczki zawierające bor jako środki przeciwzapalne

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060234981A1 (en) * 2005-02-16 2006-10-19 Anacor Pharmaceuticals Boron-containing small molecules

Also Published As

Publication number Publication date
WO2009111676A8 (en) 2010-09-30
EP2187893A2 (de) 2010-05-26
WO2009111676A2 (en) 2009-09-11
WO2009111676A3 (en) 2010-04-01

Similar Documents

Publication Publication Date Title
IL207955A0 (en) Boron - containing small molecules as anti - inflammatory agents
EP2187893A4 (de) Kleine boronhaltige moleküle als entzündungshemmende wirkstoffe
ZA200806754B (en) Boron-containing small molecules as anti-inflammatory agents
EP2285384A4 (de) Borhaltige kleine moleküle
ZA201104573B (en) Boron-containing small molecules
EP2348863A4 (de) Borhaltige kleine moleküle
IL211147A0 (en) 1h-benzimidazole-5-carboxamides as anti-inflammatory agents
IL244556B (en) Small molecules contain boron
AP4039A (en) Boron-containing small molecules as antiprotozoal agents
GB0815109D0 (en) Polydialkylsiloxane-bridged bi-photochromic molecules
ZA201008727B (en) Anti-inflammatory agents
ME02117B (me) 2-aminobenzimidazol-5-karboksamidi kao anti-inflamatorni agensi
IL218163A0 (en) Boron-cotaining small molecules as antiprotozoal agents
AP2012006482A0 (en) Boron-containing small molecules as anti-protozoalagent
ZA201100797B (en) Electrodepositable composition
GB0808196D0 (en) Topical composition
GB0816073D0 (en) Molecules
GB0814100D0 (en) 1 to 1
GB0805028D0 (en) Improvements relating to support devices
GB0801891D0 (en) Brekkie to go range
HU0800184D0 (en) Billboard using moire-effect as avisval effect

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20090327

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA RS

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1144260

Country of ref document: HK

RIN1 Information on inventor provided before grant (corrected)

Inventor name: ALLEY, MICHAEL RICHARD KEVIN

Inventor name: CHEN, DAITAO

Inventor name: JACOBS, ROBERT

Inventor name: SINGH, RAJESHWAR

Inventor name: SHARMA, RASHMI

Inventor name: SALES, MARCELO

Inventor name: LU, XIAOSONG

Inventor name: NIEMANN, JAMES A.

Inventor name: BAKER, STEPHEN J.

Inventor name: XIA, YI

Inventor name: SANDERS, VIRGINIA

Inventor name: FREUND, YVONNE

Inventor name: MAPLES, KIRK R.

Inventor name: PLATTNER, JACOB J.

Inventor name: DING, CHARLES Z.

Inventor name: ZHANG, YONG-KANG

Inventor name: AKAMA, TSUTOMU

A4 Supplementary search report drawn up and despatched

Effective date: 20120125

RIC1 Information provided on ipc code assigned before grant

Ipc: C07F 5/02 20060101ALI20120119BHEP

Ipc: A61K 31/69 20060101AFI20120119BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20120824

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1144260

Country of ref document: HK