EP2182908A2 - Vorrichtung zur verpackung und sublingualen verabreichung von wirkstoffen - Google Patents

Vorrichtung zur verpackung und sublingualen verabreichung von wirkstoffen

Info

Publication number
EP2182908A2
EP2182908A2 EP08826867A EP08826867A EP2182908A2 EP 2182908 A2 EP2182908 A2 EP 2182908A2 EP 08826867 A EP08826867 A EP 08826867A EP 08826867 A EP08826867 A EP 08826867A EP 2182908 A2 EP2182908 A2 EP 2182908A2
Authority
EP
European Patent Office
Prior art keywords
container
administration
head
preparation
liquid form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP08826867A
Other languages
English (en)
French (fr)
Other versions
EP2182908B1 (de
Inventor
Philippe Perovitch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to PL08826867T priority Critical patent/PL2182908T3/pl
Publication of EP2182908A2 publication Critical patent/EP2182908A2/de
Application granted granted Critical
Publication of EP2182908B1 publication Critical patent/EP2182908B1/de
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/18—Arrangements of closures with protective outer cap-like covers or of two or more co-operating closures
    • B65D51/20—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing
    • B65D51/22—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure
    • B65D51/221—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure a major part of the inner closure being left inside the container after the opening
    • B65D51/226—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure a major part of the inner closure being left inside the container after the opening the piercing or cutting means being non integral with, or not fixedly attached to, the outer closure
    • B65D51/227—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure a major part of the inner closure being left inside the container after the opening the piercing or cutting means being non integral with, or not fixedly attached to, the outer closure and further comprising a device first inhibiting displacement of the piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/067—Flexible ampoules, the contents of which are expelled by squeezing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A61J1/1418—Threaded type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/18—Arrangements for indicating condition of container contents, e.g. sterile condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0015—Devices specially adapted for taking medicines
    • A61J7/0046—Cups, bottles or bags
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/36—Closures with frangible parts adapted to be pierced, torn or removed, to provide discharge openings
    • B65D47/38—Closures with frangible parts adapted to be pierced, torn or removed, to provide discharge openings with piercing means arranged to act subsequently as a valve to control the opening
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1468—Containers characterised by specific material properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2251/00—Details relating to container closures
    • B65D2251/0003—Two or more closures
    • B65D2251/0006—Upper closure
    • B65D2251/0025—Upper closure of the 47-type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2251/00—Details relating to container closures
    • B65D2251/0003—Two or more closures
    • B65D2251/0068—Lower closure
    • B65D2251/0093—Membrane
    • B65D2251/0096—Membrane integral with the container

Definitions

  • the present invention relates to a device for conditioning and administration of mucous active ingredients.
  • the active ingredients dissolved in solution must be packaged in single doses, said conditioning must also allow a mucosal administration either sub-lingual or parapingival.
  • a first constraint is the extremely small volume of the dose to be administered, of the order of 0.25 ml to 2 ml to give an order of magnitude.
  • the solution is also fragile with regard to light and / or air with oxidation phenomena and sensitive to evaporation phenomena. This solution can also be the subject of adsorption or ionization phenomena at contact with the walls of the container, hence the need to resort to inert and particularly protective materials.
  • the solution in particular in the case of alcoholic solutions, must maintain its alcohol content and constant dissolution stability of the conditioned active ingredient (s), which parameters are adapted for optimized permeation.
  • the alcoholic degree is adjusted to retain the active ingredients themselves.
  • the present invention is directed to a container for the preparation and / or administration of a very small volume of active principles in liquid form
  • a container for the preparation and / or administration of a very small volume of active principles in liquid form comprising a head capable of taking a first storage position in which said head is in a distal position. relative to the container and a second administration position in which said head is proximal to the container, said head having a cannula, has at least one flow channel, the length being adapted so that the end Free flow channel can allow delivery by sublingual and / or para-gingival permeation, the container being held by hand.
  • Very low volume means a volume to be administered between 0.1 and 5 ml.
  • This device is particularly suitable for the preparation and administration of active principles and / or antigenic substances for the purpose of pharmaceutical treatment, homeopathic and / or allergic desensitization.
  • FIG. 1 a side perspective view of the packaging according to the present invention
  • FIG. 2A a sectional view of the packaging according to the present invention, before any use, ready for use,
  • FIG. 2B a sectional view of the packaging according to the present invention, after implementation of the various means for its use, ready for immediate therapeutic administration,
  • FIG. 3 conditioning with a handling and handling pallet arranged in the lower part
  • FIG. 4 a sectional view of a variant of the packaging according to the present invention, comprising several compartments, and
  • FIGS. 5A to 5C a block diagram of a schematic variant of the packaging according to the present invention.
  • FIG 1 there is shown a container 10 which can be in any material avoiding evaporation through the wall and able to avoid the action of light on the contents.
  • Such a container may be made of any material suitable for the packaged substances and the intended applications, such as glass, metal, plastic or a combination of these materials.
  • the container is preferably glass, preferably thick glass, opacified, pharmaceutical grade, with high mechanical strength, square, oval, rectangular, triangular or round. In order to make the drawings explicit, the proportion of the scales is deliberately not respected.
  • This container 10 comprises a head 12 secured at least in translation relative to said container.
  • This head is capable of taking a first position P1 in which said head 12 is distal to the container 10 and a second position of administration P2 in which said head 12 is proximal to the container 10.
  • the head 12 comprises a cannula 14, with at least one flow channel 16.
  • the length is adapted so that the free end of the flow channel 16 can be housed in particular under the language of the user or paragingival, the container being held by hand.
  • the cannula 14 comprises in addition to the flow channel 16, at least one air intake 18, for example a second channel 20.
  • This second channel 20 may be coaxial and external or juxtaposed with the first channel 16 for example.
  • the air intake can also be effected by the same first channel, according to its diameter, the liquid solution being a solution based on alcohol, so very low viscosity.
  • This cannula 14 has at its free end a mouthpiece cover 22.
  • This mouthpiece cover 22 is a sealed safety cap for example sealed and rotatably breakable for the best mode, or by traction or cutting.
  • the cannula 14 is integral with the head 12 and advantageously come from manufacture with said head.
  • the material may be a suitable polymeric material.
  • the cannula 14 comprises at the bottom 24 perforation means.
  • the container 10 and the head 12 are equipped with means 26 for translational movement of said head 12 from the distal position to the proximal position.
  • the container is also provided with safety locking means 28 so as to prevent any involuntary displacement, in translation, of the head 12 relative to the container 10.
  • the translational displacement means 26 comprise a set of screws 30 carried by the container 10, more particularly by the neck 32 of this container and a thread 34 of the conjugate profile of the thread of the container carried. by the head 12 so as to cooperate by screwing.
  • the locking means 28 comprise a removable ring 36 interposed between the head 12 in a distal position and the container 10, more particularly the shoulder 38 of this container when it is provided with it, as shown in the embodiment of FIGS. 1 and 2.
  • This ring 36 has a profile in ⁇ which is elastically mounted on the thread 30 carried by the container 10, prohibiting the translational movement of the head 12 relative to the container 10.
  • the opening of the neck 32 of the container 10 is provided with a seal 40 which is tight and capable of being perforated by the perforation means 24.
  • the head 12 comprises means 42 of total flow.
  • These flow means 42 comprise, in part internally, a conical bottom, the cannula 14 being provided, in addition to the means 24 for perforation, holes 44 of passage, arranged immediately upstream of the bottom with respect to the direction of flow, in connection with the flow channel 16.
  • the perforation means 24 comprise only a tip.
  • the container 10 is filled with the medication composition in liquid form with mucous administration and then the container 10 is closed in a sealed manner by the laying of the cap 40 which also acts as a waterproofing membrane, especially in the case of an alcoholic solution.
  • the ring 36 is disposed on the neck, around the screw thread 30, then the head 12 is attached by screwing until it comes into abutment on the ring 36.
  • the mouthpiece cover 22 is in place on the cannula 14, closing the flow channel 16 and the channel 20 of the air intake 18.
  • the packaging is not usable and can be preserved, without altering the content and without risk of accessibility to young children.
  • the removal of the mouthpiece 22 before reversal, for example by rotation causing the separation of this nozzle, allows to deliver the composition by the end of the cannula 14 positioned under the tongue or between the gum and the tongue or between the plays and the gum, the length of the cannula 14 being adapted for this purpose.
  • composition is dispensed exactly where the efficiency is optimal, this for the entire volume contained.
  • the air intake ensures a rapid distribution of the volume, which even low must be dispensed in a very short time, of the order of one second to give an order of magnitude.
  • the internal diameter of the flow channel 16 must be relatively large, of the order of 2 millimeters for the amounts mentioned above, between 0.25 and 2 ml. This proportionally large diameter can also ensure the return of air to facilitate rapid flow. In the case of using a container of the thick glass bottle type, it is possible to resort to a particular arrangement.
  • the displacement means incorporate a ferrule which is directly fixedly attached to said neck of the container, for example by crimping, said ferrule carrying the screw thread 30 necessary to cooperate with the thread 34 of the head 12.
  • the glass container is filled with the composition and then capped.
  • the ferrule is attached to the neck and crimped, then the ring 36 is positioned and the head 12 is put in place in turn.
  • the present invention proposes an improvement to the container which consists of adding a pallet 46 for gripping, advantageously disposed in the lower part of the body of the container 10.
  • This pallet 46 gripping allows a good grip bidigital, despite the small size of the container to allow the user to maneuver the head 12 in rotation.
  • this head 12 may comprise on its outer peripheral surface 48 gripping means such as fins 50, shown in the drawings.
  • the user is thus ready to maneuver by exerting a torque between the container 10 and the head 12.
  • the pallet 46 has a further handling advantage after rotation of the head relative to the container and after withdrawal of the mouthpiece cover, that of allowing easy handling of the container ready for use to position the cannula 14 at the desired location.
  • the ring 36 may be a plastic belt adapted to be torn or dessertie. To facilitate these belt removal operations, a prehensile external pull tab can be added to this belt.
  • the filling before laying the lid can be performed under an inert gas atmosphere to preserve the contents.
  • the container 10 comprises at least two compartments 52, each compartment being separated by a sealed cover 54.
  • Each compartment contains at least one active ingredient, an excipient, an antigenic substance and / or a solvent.
  • the device also comprises perforation means 24 capable of tearing the lids 40 and / or 54, preferably arranged at the foot of the cannula 14 and / or in contiguity of the compartments 52 so as to obtain mixtures of the substances in a given order .
  • the head 12 may also contain an active principle, an excipient, an antigenic substance and / or a solvent, for example at the level of the cannula 14.
  • the head 12 may also have several compartments separated by a cap 66.
  • the substance contained in the head 12 may be in the form of powder, tablet, lyoc, liquid microcapsule, etc.
  • the perforating means tear the lid (s) 40 and / or 54 and / or 66 allowing the substances contained in the head 12, in particular in the cannula 14, and in each compartment 52 to mix.
  • the perforation means tear the membrane encapsulating said substance before perforating the or lids 40 and / or 54 and / or 66.
  • the substance contained in the head 12 may also be in the form of a liquid contained in the cannula 14 of the head 12, as shown in FIG. 5.
  • the cannula 14 then comprises an upper portion 56 enclosing the liquid sealed by a lid 62, and a lower portion 58, separated by a thread 60.
  • a first rotation of the head 12 on the thread 30 causes the portion 58 to tear the seal 40 which sealed the container 10.
  • a rotation additional causes the stop portion 58 on the thread 30.
  • the cannula 14 then rotates around the second thread 60, which allows to tear the seal 62 which sealed the cannula. The liquid of the head 12 is thus released and the substances that were separated can mix.
  • container according to the invention has at least two compartments 52 and / or a head 12 containing one or more substances, are particularly suitable for active ingredients and unstable substances in solution. This is the case, for example, with lipophilic active principles, which, although perfectly soluble in hydroalcoholic solutions, exhibit unstable evolutions with risks of denaturation and formation of undesirable compounds.
  • the container according to the invention makes it possible to protect the active principle, excipient and / or antigenic substance in the form of powder, lyoc, tablet, liquid microcapsule, etc., and to carry out an extemporaneous dissolution in a solvent just before the administration. It is thus possible for certain complex and mutable components to form a device with several separate compartments for a successive assembly of these different substances not compatible just before their administration, this in a determined order.
  • the container according to the invention can be used for the preparation and / or the administration of active principles and / or antigenic substances for the purposes of pharmaceutical treatment, homeopathic and / or allergic desensitization, in particular by the transmucosal route.

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Hematology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
EP08826867.7A 2007-07-20 2008-07-18 Vorrichtung zur verpackung und sublingualen verabreichung von wirkstoffen Not-in-force EP2182908B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL08826867T PL2182908T3 (pl) 2007-07-20 2008-07-18 Urządzenie do opakowywania i do podjęzykowego podawania składników czynnych

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0705290A FR2918874B1 (fr) 2007-07-20 2007-07-20 Dispositif de conditionnement et d'administration sub-linguale de principes actifs
PCT/FR2008/051368 WO2009016309A2 (fr) 2007-07-20 2008-07-18 Dispositif de conditionnement et d'administration sub-linguale de principes actifs

Publications (2)

Publication Number Publication Date
EP2182908A2 true EP2182908A2 (de) 2010-05-12
EP2182908B1 EP2182908B1 (de) 2016-01-06

Family

ID=39144520

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08826867.7A Not-in-force EP2182908B1 (de) 2007-07-20 2008-07-18 Vorrichtung zur verpackung und sublingualen verabreichung von wirkstoffen

Country Status (13)

Country Link
US (1) US8376988B2 (de)
EP (1) EP2182908B1 (de)
JP (1) JP5912252B2 (de)
CN (1) CN101742984B (de)
BR (1) BRPI0812990A2 (de)
DK (1) DK2182908T3 (de)
ES (1) ES2562667T3 (de)
FR (1) FR2918874B1 (de)
HU (1) HUE028682T2 (de)
PL (1) PL2182908T3 (de)
PT (1) PT2182908E (de)
RU (1) RU2471474C2 (de)
WO (1) WO2009016309A2 (de)

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FR2967894B1 (fr) * 2010-11-30 2013-11-29 Philippe Perovitch Dispositif de conditionnement, de conservation et de preparation extemporanee d'un ou plusieurs principe(s) actif(s).
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FR3000896B1 (fr) 2013-01-14 2016-08-26 Philippe Perovitch Forme galenique pour l'administration de principe(s) actif(s) permettant l'induction acceleree du sommeil et/ou le traitement des troubles du sommeil
FR3031668A1 (fr) 2015-01-20 2016-07-22 Philippe Perovitch Dispositif d'administration d'un principe actif par voie per-muqueuse buccale.
EP3795208B1 (de) 2015-03-18 2023-10-18 Abiomed Europe GmbH Blutpumpe
US10624817B2 (en) 2015-03-24 2020-04-21 Neomed, Inc. Oral administration coupler for back-of-mouth delivery
FR3053244A1 (fr) 2016-07-01 2018-01-05 Philippe Perovitch Dispositif d'administration d'au moins un principe actif par voie per-muqueuse buccale.
FR3059895A1 (fr) * 2016-12-12 2018-06-15 Stickdose Dispositif d'administration d'au moins un principe actif par voie per-muqueuse buccale.
AU2018219437B2 (en) 2017-02-13 2023-03-02 Boehringer lngelheim Vetmedica GMBH Liquid applicator for delivering vaccines
DE102017002401A1 (de) * 2017-03-07 2018-09-13 Kocher-Plastik Maschinenbau Gmbh Kunststoff-Behältererzeugnis
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US11607508B1 (en) 2020-12-23 2023-03-21 Stat Capsule Inc. Device for sublingual application of a therapeutic dose of medication in fractions
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Also Published As

Publication number Publication date
WO2009016309A3 (fr) 2009-04-09
RU2471474C2 (ru) 2013-01-10
US8376988B2 (en) 2013-02-19
WO2009016309A2 (fr) 2009-02-05
BRPI0812990A2 (pt) 2014-12-16
CN101742984B (zh) 2014-06-25
JP5912252B2 (ja) 2016-04-27
RU2010106050A (ru) 2011-08-27
HUE028682T2 (en) 2016-12-28
CN101742984A (zh) 2010-06-16
PL2182908T3 (pl) 2016-06-30
ES2562667T3 (es) 2016-03-07
PT2182908E (pt) 2016-03-31
EP2182908B1 (de) 2016-01-06
FR2918874A1 (fr) 2009-01-23
US20100198147A1 (en) 2010-08-05
FR2918874B1 (fr) 2009-10-09
JP2010534081A (ja) 2010-11-04
DK2182908T3 (en) 2016-03-21

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