EP2182908A2 - Device for packaging and sublingual administration of active principles - Google Patents

Device for packaging and sublingual administration of active principles

Info

Publication number
EP2182908A2
EP2182908A2 EP08826867A EP08826867A EP2182908A2 EP 2182908 A2 EP2182908 A2 EP 2182908A2 EP 08826867 A EP08826867 A EP 08826867A EP 08826867 A EP08826867 A EP 08826867A EP 2182908 A2 EP2182908 A2 EP 2182908A2
Authority
EP
European Patent Office
Prior art keywords
container
administration
head
preparation
liquid form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP08826867A
Other languages
German (de)
French (fr)
Other versions
EP2182908B1 (en
Inventor
Philippe Perovitch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Perovitch Philippe
Original Assignee
Perovitch Philippe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perovitch Philippe filed Critical Perovitch Philippe
Priority to PL08826867T priority Critical patent/PL2182908T3/en
Publication of EP2182908A2 publication Critical patent/EP2182908A2/en
Application granted granted Critical
Publication of EP2182908B1 publication Critical patent/EP2182908B1/en
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/18—Arrangements of closures with protective outer cap-like covers or of two or more co-operating closures
    • B65D51/20—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing
    • B65D51/22—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure
    • B65D51/221—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure a major part of the inner closure being left inside the container after the opening
    • B65D51/226—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure a major part of the inner closure being left inside the container after the opening the piercing or cutting means being non integral with, or not fixedly attached to, the outer closure
    • B65D51/227—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure a major part of the inner closure being left inside the container after the opening the piercing or cutting means being non integral with, or not fixedly attached to, the outer closure and further comprising a device first inhibiting displacement of the piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/067—Flexible ampoules, the contents of which are expelled by squeezing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A61J1/1418—Threaded type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/18—Arrangements for indicating condition of container contents, e.g. sterile condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0015—Devices specially adapted for taking medicines
    • A61J7/0046—Cups, bottles or bags
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/36—Closures with frangible parts adapted to be pierced, torn, or removed, to provide discharge openings
    • B65D47/38—Closures with frangible parts adapted to be pierced, torn, or removed, to provide discharge openings with piercing means arranged to act subsequently as a valve to control the opening
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1468—Containers characterised by specific material properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2251/00—Details relating to container closures
    • B65D2251/0003—Two or more closures
    • B65D2251/0006—Upper closure
    • B65D2251/0025—Upper closure of the 47-type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2251/00—Details relating to container closures
    • B65D2251/0003—Two or more closures
    • B65D2251/0068—Lower closure
    • B65D2251/0093—Membrane
    • B65D2251/0096—Membrane integral with the container

Definitions

  • the present invention relates to a device for conditioning and administration of mucous active ingredients.
  • the active ingredients dissolved in solution must be packaged in single doses, said conditioning must also allow a mucosal administration either sub-lingual or parapingival.
  • a first constraint is the extremely small volume of the dose to be administered, of the order of 0.25 ml to 2 ml to give an order of magnitude.
  • the solution is also fragile with regard to light and / or air with oxidation phenomena and sensitive to evaporation phenomena. This solution can also be the subject of adsorption or ionization phenomena at contact with the walls of the container, hence the need to resort to inert and particularly protective materials.
  • the solution in particular in the case of alcoholic solutions, must maintain its alcohol content and constant dissolution stability of the conditioned active ingredient (s), which parameters are adapted for optimized permeation.
  • the alcoholic degree is adjusted to retain the active ingredients themselves.
  • the present invention is directed to a container for the preparation and / or administration of a very small volume of active principles in liquid form
  • a container for the preparation and / or administration of a very small volume of active principles in liquid form comprising a head capable of taking a first storage position in which said head is in a distal position. relative to the container and a second administration position in which said head is proximal to the container, said head having a cannula, has at least one flow channel, the length being adapted so that the end Free flow channel can allow delivery by sublingual and / or para-gingival permeation, the container being held by hand.
  • Very low volume means a volume to be administered between 0.1 and 5 ml.
  • This device is particularly suitable for the preparation and administration of active principles and / or antigenic substances for the purpose of pharmaceutical treatment, homeopathic and / or allergic desensitization.
  • FIG. 1 a side perspective view of the packaging according to the present invention
  • FIG. 2A a sectional view of the packaging according to the present invention, before any use, ready for use,
  • FIG. 2B a sectional view of the packaging according to the present invention, after implementation of the various means for its use, ready for immediate therapeutic administration,
  • FIG. 3 conditioning with a handling and handling pallet arranged in the lower part
  • FIG. 4 a sectional view of a variant of the packaging according to the present invention, comprising several compartments, and
  • FIGS. 5A to 5C a block diagram of a schematic variant of the packaging according to the present invention.
  • FIG 1 there is shown a container 10 which can be in any material avoiding evaporation through the wall and able to avoid the action of light on the contents.
  • Such a container may be made of any material suitable for the packaged substances and the intended applications, such as glass, metal, plastic or a combination of these materials.
  • the container is preferably glass, preferably thick glass, opacified, pharmaceutical grade, with high mechanical strength, square, oval, rectangular, triangular or round. In order to make the drawings explicit, the proportion of the scales is deliberately not respected.
  • This container 10 comprises a head 12 secured at least in translation relative to said container.
  • This head is capable of taking a first position P1 in which said head 12 is distal to the container 10 and a second position of administration P2 in which said head 12 is proximal to the container 10.
  • the head 12 comprises a cannula 14, with at least one flow channel 16.
  • the length is adapted so that the free end of the flow channel 16 can be housed in particular under the language of the user or paragingival, the container being held by hand.
  • the cannula 14 comprises in addition to the flow channel 16, at least one air intake 18, for example a second channel 20.
  • This second channel 20 may be coaxial and external or juxtaposed with the first channel 16 for example.
  • the air intake can also be effected by the same first channel, according to its diameter, the liquid solution being a solution based on alcohol, so very low viscosity.
  • This cannula 14 has at its free end a mouthpiece cover 22.
  • This mouthpiece cover 22 is a sealed safety cap for example sealed and rotatably breakable for the best mode, or by traction or cutting.
  • the cannula 14 is integral with the head 12 and advantageously come from manufacture with said head.
  • the material may be a suitable polymeric material.
  • the cannula 14 comprises at the bottom 24 perforation means.
  • the container 10 and the head 12 are equipped with means 26 for translational movement of said head 12 from the distal position to the proximal position.
  • the container is also provided with safety locking means 28 so as to prevent any involuntary displacement, in translation, of the head 12 relative to the container 10.
  • the translational displacement means 26 comprise a set of screws 30 carried by the container 10, more particularly by the neck 32 of this container and a thread 34 of the conjugate profile of the thread of the container carried. by the head 12 so as to cooperate by screwing.
  • the locking means 28 comprise a removable ring 36 interposed between the head 12 in a distal position and the container 10, more particularly the shoulder 38 of this container when it is provided with it, as shown in the embodiment of FIGS. 1 and 2.
  • This ring 36 has a profile in ⁇ which is elastically mounted on the thread 30 carried by the container 10, prohibiting the translational movement of the head 12 relative to the container 10.
  • the opening of the neck 32 of the container 10 is provided with a seal 40 which is tight and capable of being perforated by the perforation means 24.
  • the head 12 comprises means 42 of total flow.
  • These flow means 42 comprise, in part internally, a conical bottom, the cannula 14 being provided, in addition to the means 24 for perforation, holes 44 of passage, arranged immediately upstream of the bottom with respect to the direction of flow, in connection with the flow channel 16.
  • the perforation means 24 comprise only a tip.
  • the container 10 is filled with the medication composition in liquid form with mucous administration and then the container 10 is closed in a sealed manner by the laying of the cap 40 which also acts as a waterproofing membrane, especially in the case of an alcoholic solution.
  • the ring 36 is disposed on the neck, around the screw thread 30, then the head 12 is attached by screwing until it comes into abutment on the ring 36.
  • the mouthpiece cover 22 is in place on the cannula 14, closing the flow channel 16 and the channel 20 of the air intake 18.
  • the packaging is not usable and can be preserved, without altering the content and without risk of accessibility to young children.
  • the removal of the mouthpiece 22 before reversal, for example by rotation causing the separation of this nozzle, allows to deliver the composition by the end of the cannula 14 positioned under the tongue or between the gum and the tongue or between the plays and the gum, the length of the cannula 14 being adapted for this purpose.
  • composition is dispensed exactly where the efficiency is optimal, this for the entire volume contained.
  • the air intake ensures a rapid distribution of the volume, which even low must be dispensed in a very short time, of the order of one second to give an order of magnitude.
  • the internal diameter of the flow channel 16 must be relatively large, of the order of 2 millimeters for the amounts mentioned above, between 0.25 and 2 ml. This proportionally large diameter can also ensure the return of air to facilitate rapid flow. In the case of using a container of the thick glass bottle type, it is possible to resort to a particular arrangement.
  • the displacement means incorporate a ferrule which is directly fixedly attached to said neck of the container, for example by crimping, said ferrule carrying the screw thread 30 necessary to cooperate with the thread 34 of the head 12.
  • the glass container is filled with the composition and then capped.
  • the ferrule is attached to the neck and crimped, then the ring 36 is positioned and the head 12 is put in place in turn.
  • the present invention proposes an improvement to the container which consists of adding a pallet 46 for gripping, advantageously disposed in the lower part of the body of the container 10.
  • This pallet 46 gripping allows a good grip bidigital, despite the small size of the container to allow the user to maneuver the head 12 in rotation.
  • this head 12 may comprise on its outer peripheral surface 48 gripping means such as fins 50, shown in the drawings.
  • the user is thus ready to maneuver by exerting a torque between the container 10 and the head 12.
  • the pallet 46 has a further handling advantage after rotation of the head relative to the container and after withdrawal of the mouthpiece cover, that of allowing easy handling of the container ready for use to position the cannula 14 at the desired location.
  • the ring 36 may be a plastic belt adapted to be torn or dessertie. To facilitate these belt removal operations, a prehensile external pull tab can be added to this belt.
  • the filling before laying the lid can be performed under an inert gas atmosphere to preserve the contents.
  • the container 10 comprises at least two compartments 52, each compartment being separated by a sealed cover 54.
  • Each compartment contains at least one active ingredient, an excipient, an antigenic substance and / or a solvent.
  • the device also comprises perforation means 24 capable of tearing the lids 40 and / or 54, preferably arranged at the foot of the cannula 14 and / or in contiguity of the compartments 52 so as to obtain mixtures of the substances in a given order .
  • the head 12 may also contain an active principle, an excipient, an antigenic substance and / or a solvent, for example at the level of the cannula 14.
  • the head 12 may also have several compartments separated by a cap 66.
  • the substance contained in the head 12 may be in the form of powder, tablet, lyoc, liquid microcapsule, etc.
  • the perforating means tear the lid (s) 40 and / or 54 and / or 66 allowing the substances contained in the head 12, in particular in the cannula 14, and in each compartment 52 to mix.
  • the perforation means tear the membrane encapsulating said substance before perforating the or lids 40 and / or 54 and / or 66.
  • the substance contained in the head 12 may also be in the form of a liquid contained in the cannula 14 of the head 12, as shown in FIG. 5.
  • the cannula 14 then comprises an upper portion 56 enclosing the liquid sealed by a lid 62, and a lower portion 58, separated by a thread 60.
  • a first rotation of the head 12 on the thread 30 causes the portion 58 to tear the seal 40 which sealed the container 10.
  • a rotation additional causes the stop portion 58 on the thread 30.
  • the cannula 14 then rotates around the second thread 60, which allows to tear the seal 62 which sealed the cannula. The liquid of the head 12 is thus released and the substances that were separated can mix.
  • container according to the invention has at least two compartments 52 and / or a head 12 containing one or more substances, are particularly suitable for active ingredients and unstable substances in solution. This is the case, for example, with lipophilic active principles, which, although perfectly soluble in hydroalcoholic solutions, exhibit unstable evolutions with risks of denaturation and formation of undesirable compounds.
  • the container according to the invention makes it possible to protect the active principle, excipient and / or antigenic substance in the form of powder, lyoc, tablet, liquid microcapsule, etc., and to carry out an extemporaneous dissolution in a solvent just before the administration. It is thus possible for certain complex and mutable components to form a device with several separate compartments for a successive assembly of these different substances not compatible just before their administration, this in a determined order.
  • the container according to the invention can be used for the preparation and / or the administration of active principles and / or antigenic substances for the purposes of pharmaceutical treatment, homeopathic and / or allergic desensitization, in particular by the transmucosal route.

Abstract

The invention relates to a container for the preparation and/or administration of a very small volume of active principles in liquid form, comprising a head (12) that is able to assume a first position P1 or storage position, in which said head (12) is in a distal position with respect to the container, and a second position P2 or administration position, in which said head (12) is in a proximal position with respect to the container, this head (12) comprising a cannula (14) with at least one flow channel (16), the length being adapted such that, with the container being held in the hand, the free end of the flow channel (16) is able to permit delivery by sublingual and/or gingival permeation.

Description

DISPOSITIF DE CONDITIONNEMENT ET D'ADMINISTRATION SUBLINGUALE DE PRINCIPES ACTIFS DEVICE FOR CONDITIONING AND SUBLINGUAL ADMINISTRATION OF ACTIVE PRINCIPLES
La présente invention concerne un dispositif de conditionnement et d'administration per-muqueuse de principes actifs.The present invention relates to a device for conditioning and administration of mucous active ingredients.
Il existe des procédés de diffusion de principes actifs par perméation sublinguale et/ou para-gingivale qui offrent de nombreux avantages. En effet, ces procédés de diffusion permettent d'obtenir des actions beaucoup plus rapides, avec des dosages beaucoup plus faibles de principes actifs et de façon plus ciblée en éliminant de très nombreux effets secondaires. Ces effets secondaires sont notamment engendrés par le fait que les médicaments à administration par voie orale sont métabolisés par les différents organes digestifs avant de diffuser vers les cibles visées par les principes actifs. Si cette voie d'administration per-muqueuse est particulièrement attractive, elle reste néanmoins liée à des contraintes auxquelles il convient de pallier pour en permettre une mise en oeuvre aisée par les patients.There are methods of diffusion of active principles by sublingual and / or para-gingival permeation that offer many advantages. Indeed, these diffusion methods allow to obtain much faster actions, with much lower dosages of active ingredients and more targeted by eliminating many side effects. These side effects are notably caused by the fact that the drugs to be administered orally are metabolized by the various digestive organs before diffusing towards the targets targeted by the active ingredients. Although this mucosal administration route is particularly attractive, it nevertheless remains linked to constraints that must be overcome to allow easy implementation by patients.
Les principes actifs mis en solution, notamment mis en solution dans des solutions alcooliques, doivent être conditionnés en unidoses, ledit conditionnement devant aussi permettre une administration per-muqueuse soit sub-linguale soit para- gingivale.The active ingredients dissolved in solution, especially dissolved in alcoholic solutions, must be packaged in single doses, said conditioning must also allow a mucosal administration either sub-lingual or parapingival.
Une première contrainte est le volume extrêmement réduit de la dose à administrer, de l'ordre de 0,25 ml à 2 ml pour donner un ordre de grandeur. La solution est également fragile au regard de la lumière et/ou de l'air avec des phénomènes d'oxydation et sensible aux phénomènes d'évaporation. Cette solution peut aussi faire l'objet de phénomènes d'adsorption ou d'ionisation au contact des parois du contenant, d'où la nécessité de recourir à des matériaux inertes et particulièrement protecteurs.A first constraint is the extremely small volume of the dose to be administered, of the order of 0.25 ml to 2 ml to give an order of magnitude. The solution is also fragile with regard to light and / or air with oxidation phenomena and sensitive to evaporation phenomena. This solution can also be the subject of adsorption or ionization phenomena at contact with the walls of the container, hence the need to resort to inert and particularly protective materials.
Or la solution notamment dans le cas de solutions alcooliques doit conserver son degré alcoolique et une stabilité de dissolution constante du ou des principes actifs conditionnés, paramètres qui sont adaptés pour une perméation optimisée. De plus, le degré alcoolique est ajusté pour conserver les principes actifs eux- mêmes.However, the solution, in particular in the case of alcoholic solutions, must maintain its alcohol content and constant dissolution stability of the conditioned active ingredient (s), which parameters are adapted for optimized permeation. In addition, the alcoholic degree is adjusted to retain the active ingredients themselves.
Il importe de conserver le degré alcoolique initialement prévu. En outre, pour certaines substances pharmacologiques instables, leur mise en dissolution ne doit être pratiquée qu'extemporanément, au moment même de l'administration, faute de quoi ils seraient altérés, donc inactifs. Une contrainte omniprésente pour un tel conditionnement unidose est le coût de fabrication qui doit être extrêmement réduit compte tenu du nombre de conditionnements à réaliser et du fait d'un usage unique par principe même. Son recyclage après usage doit également être favorisé. Néanmoins, le conditionnement doit conserver les impératifs de sécurité, d'asepsie, en plus de la praticité et de l'ergonomie recherchées, pour garantir une mise à disposition aisée en automédication.It is important to maintain the alcoholic degree initially planned. In addition, for certain unstable pharmacological substances, their dissolution must be practiced only extemporaneously, at the very moment of administration, otherwise they would be altered, therefore inactive. An omnipresent constraint for such a single-dose packaging is the manufacturing cost, which must be extremely reduced in view of the number of packages to be produced and because of a single use in principle. Its recycling after use should also be promoted. Nevertheless, the packaging must maintain the requirements of safety, asepsis, in addition to the practicality and ergonomics sought to ensure easy provision self-medication.
C'est pourquoi la présente invention vise un contenant pour la préparation et/ ou l'administration d'un très faible volume de principes actifs sous forme liquide comprenant une tête apte à prendre une première position de conservation dans laquelle ladite tête est en position distale par rapport au contenant et une seconde position d'administration dans laquelle ladite tête est en position proximale par rapport au contenant, cette tête comportant une canule, a^ec au moins un canal d'écoulement, la longueur étant adaptée pour que l'extrémité libre du canal d'écoulement puisse permettre une délivrance par perméation sublinguale et/ou para-gingivale, le contenant étant tenu à la main. Par très faible volume on entend un volume à administrer compris entre 0,1 et 5 ml.This is why the present invention is directed to a container for the preparation and / or administration of a very small volume of active principles in liquid form comprising a head capable of taking a first storage position in which said head is in a distal position. relative to the container and a second administration position in which said head is proximal to the container, said head having a cannula, has at least one flow channel, the length being adapted so that the end Free flow channel can allow delivery by sublingual and / or para-gingival permeation, the container being held by hand. Very low volume means a volume to be administered between 0.1 and 5 ml.
Ce dispositif est particulièrement adapté à la préparation et l'administration de principes actifs et/ou de substances antigéniques à des fins de traitement pharmaceutique, homéopathique et/ou de désensibilisation allergique.This device is particularly suitable for the preparation and administration of active principles and / or antigenic substances for the purpose of pharmaceutical treatment, homeopathic and / or allergic desensitization.
Le conditionnement selon la présente invention est maintenant décrit en détail suivant un mode de réalisation particulier, non limitatif, en regard des dessins annexés, dessins sur lesquels les différentes figures représentent :The packaging according to the present invention is now described in detail according to a particular embodiment, not limiting, with reference to the attached drawings, drawings in which the different figures represent:
- figure 1 : une vue en perspective latérale du conditionnement selon la présente invention,FIG. 1: a side perspective view of the packaging according to the present invention,
- figure 2A : une vue en coupe du conditionnement selon la présente invention, avant toute utilisation, prêt pour l'usage,FIG. 2A: a sectional view of the packaging according to the present invention, before any use, ready for use,
- figure 2B : une vue en coupe du conditionnement selon la présente invention, après mise en oeuvre des différents moyens permettant son utilisation, prêt pour une administration thérapeutique immédiate,- Figure 2B: a sectional view of the packaging according to the present invention, after implementation of the various means for its use, ready for immediate therapeutic administration,
- figure 3 : conditionnement a^ec une palette de préhension et de manipulation disposée en partie inférieure,FIG. 3: conditioning with a handling and handling pallet arranged in the lower part,
- figure 4 : une vue en coupe d'une variante du conditionnement selon la présente invention, comprenant plusieurs compartiments, etFIG. 4: a sectional view of a variant of the packaging according to the present invention, comprising several compartments, and
- figure 5A à 5C : un synoptique de fonctionnement d'une variante schématique du conditionnement selon la présente invention.FIGS. 5A to 5C: a block diagram of a schematic variant of the packaging according to the present invention.
Sur la figure 1, on a représenté un contenant 10 qui peut être en toute matière évitant l'évaporation à travers la paroi et apte à éviter l'action de la lumière sur le contenu.In Figure 1, there is shown a container 10 which can be in any material avoiding evaporation through the wall and able to avoid the action of light on the contents.
Un tel contenant peut être réalisé en tout matériau adapté aux substances conditionnées et aux applications visées, tel que du verre, du métal, du plastique ou une association de ces matériaux. Le contenant est avantageusement en verre, de préférence en verre épais, opacifié, de qualité pharmaceutique, avec une haute résistance mécanique, de section carrée, ovale, rectangulaire, triangulaire ou ronde. Afin de rendre les dessins explicites, la proportion des échelles n'est volontairement pas respectée.Such a container may be made of any material suitable for the packaged substances and the intended applications, such as glass, metal, plastic or a combination of these materials. The container is preferably glass, preferably thick glass, opacified, pharmaceutical grade, with high mechanical strength, square, oval, rectangular, triangular or round. In order to make the drawings explicit, the proportion of the scales is deliberately not respected.
Ce contenant 10 comprend une tête 12, solidarisée de façon mobile au moins en translation par rapport audit contenant.This container 10 comprises a head 12 secured at least in translation relative to said container.
Cette tête est apte à prendre une première position Pl de conservation dans laquelle ladite tête 12 est en position distale par rapport au contenant 10 et une seconde position P2 d'administration dans laquelle ladite tête 12 est en position proximale par rapport au contenant 10.This head is capable of taking a first position P1 in which said head 12 is distal to the container 10 and a second position of administration P2 in which said head 12 is proximal to the container 10.
La tête 12 comporte une canule 14, avec au moins un canal 16 d'écoulement. La longueur est adaptée pour que l'extrémité libre du canal 16 d'écoulement puisse venir se loger notamment sous la langue de l'utilisateur ou en para- gingival, le contenant étant tenu à la main.The head 12 comprises a cannula 14, with at least one flow channel 16. The length is adapted so that the free end of the flow channel 16 can be housed in particular under the language of the user or paragingival, the container being held by hand.
La canule 14 comprend en plus du canal 16 d'écoulement, au moins une prise d'air 18, par exemple un second canal 20. Ce second canal 20 peut être coaxial et externe ou juxtaposé au premier canal 16 par exemple. La prise d'air peut aussi s'effectuer par le même premier canal, suivant son diamètre, la solution liquide étant une solution à base d'alcool, donc de très faible viscosité. Cette canule 14 comporte à son extrémité libre un couvre embout buccal 22. Ce couvre embout buccal 22 est un bouchon scellé de sécurité par exemple scellé et ruptable par rotation pour le meilleur mode, ou par traction ou par découpe. La canule 14 est solidaire de la tête 12 et avantageusement venue de fabrication avec ladite tête. Le matériau peut être une matière polymère adaptée. La canule 14 comprend en pied des moyens 24 de perforation. Le contenant 10 et la tête 12 sont équipés de moyens 26 de déplacement en translation de ladite tête 12 de la position distale à la position proximale. Le contenant est aussi muni de moyens 28 de verrouillage de sécurité de façon à interdire tout déplacement involontaire, en translation, de la tête 12 par rapport au contenant 10.The cannula 14 comprises in addition to the flow channel 16, at least one air intake 18, for example a second channel 20. This second channel 20 may be coaxial and external or juxtaposed with the first channel 16 for example. The air intake can also be effected by the same first channel, according to its diameter, the liquid solution being a solution based on alcohol, so very low viscosity. This cannula 14 has at its free end a mouthpiece cover 22. This mouthpiece cover 22 is a sealed safety cap for example sealed and rotatably breakable for the best mode, or by traction or cutting. The cannula 14 is integral with the head 12 and advantageously come from manufacture with said head. The material may be a suitable polymeric material. The cannula 14 comprises at the bottom 24 perforation means. The container 10 and the head 12 are equipped with means 26 for translational movement of said head 12 from the distal position to the proximal position. The container is also provided with safety locking means 28 so as to prevent any involuntary displacement, in translation, of the head 12 relative to the container 10.
Dans le mode de réalisation préféré, les moyens 26 de déplacement en translation comprennent un ensemble pas de vis 30 porté par le contenant 10, plus particulièrement par le col 32 de ce contenant et un filetage 34 de profil conjugué du pas de vis du contenant porté par la tête 12 de façon à coopérer par vissage.In the preferred embodiment, the translational displacement means 26 comprise a set of screws 30 carried by the container 10, more particularly by the neck 32 of this container and a thread 34 of the conjugate profile of the thread of the container carried. by the head 12 so as to cooperate by screwing.
Les moyens 28 de verrouillage comprennent une bague 36 amovible, interposée entre la tête 12 en position distale et le contenant 10, plus particulièrement l'épaulement 38 de ce contenant lorsqu'il en est muni, ainsi que représenté sur le mode de réalisation des figures 1 et 2.The locking means 28 comprise a removable ring 36 interposed between the head 12 in a distal position and the container 10, more particularly the shoulder 38 of this container when it is provided with it, as shown in the embodiment of FIGS. 1 and 2.
Cette bague 36 a un profil en Ç qui vient se monter élastiquement sur le pas de vis 30 porté par le contenant 10, interdisant le mouvement en translation de la tête 12 par rapport à ce contenant 10.This ring 36 has a profile in Ç which is elastically mounted on the thread 30 carried by the container 10, prohibiting the translational movement of the head 12 relative to the container 10.
De façon complémentaire, l'ouverture du col 32 du contenant 10 est munie d'un opercule 40 étanche et apte à être perforé par les moyens 24 de perforation. De façon avantageuse, afin d'assurer une administration de l'intégralité de la composition médicamenteuse sous forme liquide, la tête 12 comprend des moyens 42 d'écoulement total. Ces moyens 42 d'écoulement comprennent, en partie interne, un fond conique, la canule 14 étant munie, en plus des moyens 24 de perforation, de trous 44 de passage, disposés immédiatement en amont du fond par rapport au sens d'écoulement, en liaison avec la canal 16 d'écoulement. Dans ce cas, les moyens 24 de perforation comprennent uniquement une pointe. Ainsi, le contenant 10 est empli de la composition médication sous forme liquide à administration per-muqueuse puis le contenant 10 est obturé de façon étanche par la pose de l'opercule 40 qui joue aussi le rôle de membrane d'étanchéité, surtout dans le cas d'une solution alcoolique. La bague 36 est disposée sur le col, autour du pas de vis 30, puis la tête 12 est rapportée par vissage jusqu'à venir en butée sur la bague 36.In a complementary manner, the opening of the neck 32 of the container 10 is provided with a seal 40 which is tight and capable of being perforated by the perforation means 24. Advantageously, in order to ensure administration of the entire drug composition in liquid form, the head 12 comprises means 42 of total flow. These flow means 42 comprise, in part internally, a conical bottom, the cannula 14 being provided, in addition to the means 24 for perforation, holes 44 of passage, arranged immediately upstream of the bottom with respect to the direction of flow, in connection with the flow channel 16. In this case, the perforation means 24 comprise only a tip. Thus, the container 10 is filled with the medication composition in liquid form with mucous administration and then the container 10 is closed in a sealed manner by the laying of the cap 40 which also acts as a waterproofing membrane, especially in the case of an alcoholic solution. The ring 36 is disposed on the neck, around the screw thread 30, then the head 12 is attached by screwing until it comes into abutment on the ring 36.
Le couvre embout buccal 22 est en place sur la canule 14, obturant le canal 16 d'écoulement et le canal 20 de la prise d'air 18.The mouthpiece cover 22 is in place on the cannula 14, closing the flow channel 16 and the channel 20 of the air intake 18.
Dans cette position de conservation, le conditionnement n'est pas utilisable et peut être conservé, sans altération du contenu et sans risque d'accessibilité aux jeunes enfants.In this conservation position, the packaging is not usable and can be preserved, without altering the content and without risk of accessibility to young children.
Lorsque l'utilisateur souhaite s'administrer ou administrer la composition médicamenteuse, il lui suffit de retirer la bague 36 par simple traction puis de visser la tête 12.When the user wishes to administer or administer the drug composition, it suffices to remove the ring 36 by simply pulling and screwing the head 12.
Il se produit alors un déplacement en translation de ladite tête qui amène les moyens de perforation à déchirer l'opercule qui assurait le scellage, permettant au liquide de couler vers la canule lorsque le contenant est retourné.There then occurs a displacement in translation of said head which causes the perforating means to tear the lid which ensured the seal, allowing the liquid to flow to the cannula when the container is returned.
Le retrait de l'embout buccal 22 avant retournement, par exemple par rotation provoquant la désolidarisation de cet embout, permet de délivrer la composition par l'extrémité de la canule 14 positionnée sous la langue ou entre la gencive et la langue ou encore entre la joue et la gencive, la longueur de la canule 14 étant adaptée à cet effet.The removal of the mouthpiece 22 before reversal, for example by rotation causing the separation of this nozzle, allows to deliver the composition by the end of the cannula 14 positioned under the tongue or between the gum and the tongue or between the plays and the gum, the length of the cannula 14 being adapted for this purpose.
Ainsi, la composition est dispensée exactement à l'endroit où l'efficacité est optimale, ceci pour la totalité du volume contenu.Thus, the composition is dispensed exactly where the efficiency is optimal, this for the entire volume contained.
On note que la prise d'air assure une distribution rapide du volume, qui même faible doit être dispensé en un temps très court, de l'ordre de la seconde pour donner un ordre de grandeur.It is noted that the air intake ensures a rapid distribution of the volume, which even low must be dispensed in a very short time, of the order of one second to give an order of magnitude.
A cet effet, le diamètre interne du canal 16 d'écoulement doit être relativement important, de l'ordre de 2 millimètres pour les quantités mentionnées ci-avant, comprises entre 0,25 et 2 ml. Ce diamètre proportionnellement important peut aussi assurer la remontée d'air pour faciliter l'écoulement rapide. Dans le cas d'un recours à un contenant du type flacon en verre épais, il est possible de recourir à un agencement particulier.For this purpose, the internal diameter of the flow channel 16 must be relatively large, of the order of 2 millimeters for the amounts mentioned above, between 0.25 and 2 ml. This proportionally large diameter can also ensure the return of air to facilitate rapid flow. In the case of using a container of the thick glass bottle type, it is possible to resort to a particular arrangement.
Soit le col porte un pas de vis 30 venu de fabrication avec le contenant, soit le col est lisse. Dans le cas d'un col lisse, les moyens de déplacement intègrent une virole qui est directement rapportée de façon fixe sur ledit col du contenant, par exemple par sertissage, ladite virole portant le pas de vis 30 nécessaire pour coopérer avec le filetage 34 de la tête 12.Either the neck carries a screw thread 30 come from manufacture with the container, or the neck is smooth. In the case of a smooth neck, the displacement means incorporate a ferrule which is directly fixedly attached to said neck of the container, for example by crimping, said ferrule carrying the screw thread 30 necessary to cooperate with the thread 34 of the head 12.
Dans ce cas, le contenant en verre est empli de la composition puis operculé.In this case, the glass container is filled with the composition and then capped.
Ensuite, la virole est rapportée sur le col et sertie, puis la bague 36 est positionnée puis la tête 12 est mise en place à son tour.Then, the ferrule is attached to the neck and crimped, then the ring 36 is positioned and the head 12 is put in place in turn.
Pour l'utilisation, l'utilisateur agit exactement comme indiqué précédemment.For use, the user acts exactly as indicated above.
Ainsi que cela vient d'être décrit, les dimensions du flacon on été maximisées pour permettre de faire apparaître les détails de constitution mais il faut prendre en compte le fait qu'un contenant de 0,25 à 2 ml est extrêmement petit et difficile à manipuler.As has just been described, the dimensions of the bottle have been maximized to reveal the details of constitution but it must be taken into account that a container of 0.25 to 2 ml is extremely small and difficult to manipulate.
Aussi la présente invention propose un perfectionnement au contenant qui consiste à adjoindre une palette 46 de préhension, disposée avantageusement en partie inférieure du corps du contenant 10.Also the present invention proposes an improvement to the container which consists of adding a pallet 46 for gripping, advantageously disposed in the lower part of the body of the container 10.
Cette palette 46 de préhension permet une bonne saisie en pince bidigitale, malgré la petitesse du contenant afin de permettre à l'utilisateur de manoeuvrer la tête 12 en rotation.This pallet 46 gripping allows a good grip bidigital, despite the small size of the container to allow the user to maneuver the head 12 in rotation.
De même, cette tête 12 peut comporter sur sa surface extérieure périphérique des moyens 48 de préhension comme des ailettes 50, représentées sur les dessins.Similarly, this head 12 may comprise on its outer peripheral surface 48 gripping means such as fins 50, shown in the drawings.
L'utilisateur est ainsi prêt à manoeuvrer en exerçant un couple entre le contenant 10 et la tête 12.The user is thus ready to maneuver by exerting a torque between the container 10 and the head 12.
On note aussi que la palette 46 de préhension présente un autre avantage de manipulation après rotation de la tête par rapport au contenant et après retrait du couvre embout buccal, celui d'autoriser une manipulation aisée du contenant prêt à l'usage pour positionner la canule 14 à l'endroit désiré.Note also that the pallet 46 has a further handling advantage after rotation of the head relative to the container and after withdrawal of the mouthpiece cover, that of allowing easy handling of the container ready for use to position the cannula 14 at the desired location.
En variante, la bague 36 peut être une ceinture plastique apte à être déchirée ou dessertie. Afin de faciliter ces opérations de retrait de la ceinture, une languette externe préhensible de traction peut être adjointe à cette ceinture.Alternatively, the ring 36 may be a plastic belt adapted to be torn or dessertie. To facilitate these belt removal operations, a prehensile external pull tab can be added to this belt.
De même le remplissage avant pose de l'opercule peut être réalisé sous atmosphère de gaz inerte pour préserver le contenu.Similarly, the filling before laying the lid can be performed under an inert gas atmosphere to preserve the contents.
Selon une autre variante de l'invention représentée sur la figure 4, le contenant 10 comprend au moins deux compartiments 52, chaque compartiment étant séparé par un opercule étanche 54.According to another variant of the invention shown in FIG. 4, the container 10 comprises at least two compartments 52, each compartment being separated by a sealed cover 54.
Chaque compartiment contient au moins un principe actif, un excipient, une substance antigénique et/ou un solvant.Each compartment contains at least one active ingredient, an excipient, an antigenic substance and / or a solvent.
Le dispositif comprend également des moyens 24 de perforation aptes à déchirer le ou les opercules 40 et/ou 54, préférentiellement disposés en pied de canule 14 et/ou en contiguïté des compartiments 52 de façon à pouvoir obtenir des mélanges des substances dans un ordre déterminé.The device also comprises perforation means 24 capable of tearing the lids 40 and / or 54, preferably arranged at the foot of the cannula 14 and / or in contiguity of the compartments 52 so as to obtain mixtures of the substances in a given order .
Lorsque l'utilisateur souhaite s'administrer ou administrer la composition médicamenteuse, il retire la bague 36 par traction puis visse la tête 12. Il se produit alors un déplacement en translation de ladite tête qui amène les moyens de perforation à déchirer le ou les opercules 40 et/ou 54, permettant aux substances contenues dans chaque compartiment 52 de se mélanger pour obtenir un liquide qui coule vers la canule lorsque le contenant est retourné.When the user wishes to administer or administer the drug composition, he removes the ring 36 by traction and then screws the head 12. There then occurs a displacement in translation of said head which causes the perforating means to tear the lid or lids 40 and / or 54, allowing the substances contained in each compartment 52 to mix to obtain a liquid flowing to the cannula when the container is returned.
La tête 12 peut également contenir un principe actif, un excipient, une substance antigénique et/ou un solvant, par exemple au niveau de la canule 14. La tête 12 peut également présenter plusieurs compartiments séparés par un opercule 66.The head 12 may also contain an active principle, an excipient, an antigenic substance and / or a solvent, for example at the level of the cannula 14. The head 12 may also have several compartments separated by a cap 66.
La substance contenue dans la tête 12 peut se présenter sous forme de poudre, de comprimé, de lyoc, de microcapsule liquidienne, etc. Lorsque la tête se déplace en translation, les moyens de perforation déchirent le ou les opercules 40 et/ou 54 et/ou 66 permettant aux substances contenues dans la tête 12, notamment dans la canule 14, et dans chaque compartiment 52 de se mélanger. De même si la substance contenue dans la tête 12 est encapsulée, les moyens de perforation déchirent la membrane encapsulant ladite substance avant de perforer le ou les opercules 40 et/ou 54 et/ou 66.The substance contained in the head 12 may be in the form of powder, tablet, lyoc, liquid microcapsule, etc. When the head moves in translation, the perforating means tear the lid (s) 40 and / or 54 and / or 66 allowing the substances contained in the head 12, in particular in the cannula 14, and in each compartment 52 to mix. Similarly, if the substance contained in the head 12 is encapsulated, the perforation means tear the membrane encapsulating said substance before perforating the or lids 40 and / or 54 and / or 66.
La substance contenue dans la tête 12 peut également se présenter sous forme d'un liquide contenu dans la canule 14 de la tête 12, comme représenté sur la figure 5. La canule 14 comporte alors une partie haute 56 renfermant le liquide scellée par un opercule étanche 62, et une partie basse 58, séparées par un pas de vis 60. Une première rotation de la tête 12 sur le pas de vis 30 amène la partie 58 à déchirer l'opercule 40 qui assurait le scellage du contenant 10. Une rotation supplémentaire entraîne la butée de la partie 58 sur le pas de vis 30. La canule 14 tourne alors autour du second pas de vis 60, ce qui permet de déchirer l'opercule 62 qui assurait le scellage de la canule. Le liquide de la tête 12 est ainsi libéré et les substances qui étaient séparées peuvent se mélanger. Ces formes de contenant selon l'invention a^ec au moins deux compartiments 52 et/ou une tête 12 contenant une ou plusieurs substances, sont particulièrement adaptées aux principes actifs et substances instables en solution. C'est le cas par exemple des principes actifs lipophiles, qui, bien que parfaitement solubles dans des solutions hydroalcooliques, présentent des évolutions instables a^ec des risques de dénaturation et de formation de composés indésirables. Le contenant selon l'invention permet de protéger le principe actif, excipient et/ou substance antigénique sous forme de poudre, de lyoc, de comprimé, de microcapsule liquidienne, etc., et de réaliser une dissolution extemporanée dans un solvant juste avant l'administration. Il est ainsi possible pour certains composants complexes et altérables entre eux, de constituer un dispositif à plusieurs compartiments séparés permettant un assemblage successifs de ces différentes substances peu compatibles juste avant leur administration,ceci dans un ordre déterminé.The substance contained in the head 12 may also be in the form of a liquid contained in the cannula 14 of the head 12, as shown in FIG. 5. The cannula 14 then comprises an upper portion 56 enclosing the liquid sealed by a lid 62, and a lower portion 58, separated by a thread 60. A first rotation of the head 12 on the thread 30 causes the portion 58 to tear the seal 40 which sealed the container 10. A rotation additional causes the stop portion 58 on the thread 30. The cannula 14 then rotates around the second thread 60, which allows to tear the seal 62 which sealed the cannula. The liquid of the head 12 is thus released and the substances that were separated can mix. These forms of container according to the invention has at least two compartments 52 and / or a head 12 containing one or more substances, are particularly suitable for active ingredients and unstable substances in solution. This is the case, for example, with lipophilic active principles, which, although perfectly soluble in hydroalcoholic solutions, exhibit unstable evolutions with risks of denaturation and formation of undesirable compounds. The container according to the invention makes it possible to protect the active principle, excipient and / or antigenic substance in the form of powder, lyoc, tablet, liquid microcapsule, etc., and to carry out an extemporaneous dissolution in a solvent just before the administration. It is thus possible for certain complex and mutable components to form a device with several separate compartments for a successive assembly of these different substances not compatible just before their administration, this in a determined order.
Le contenant selon l'invention peut être utilisé pour la préparation et/ou l'administration de principes actifs et/ou de substances antigéniques à des fins de traitement pharmaceutique, homéopathique et/ou de désensibilisation allergique, notamment par voie trans-muqueuse. The container according to the invention can be used for the preparation and / or the administration of active principles and / or antigenic substances for the purposes of pharmaceutical treatment, homeopathic and / or allergic desensitization, in particular by the transmucosal route.

Claims

REVENDICATIONS
1. Contenant (10) pour la préparation et/ou l'administration d'un très faible volume de principes actifs sous forme liquide comprenant une tête (12) apte à prendre une première position Pl de conservation dans laquelle ladite tête (12) est en position distale par rapport au contenant (10) et une seconde position P2 d'administration dans laquelle ladite tête (12) est en position proximale par rapport au contenant (10), cette tête (12) comportant une canule (14), avec au moins un canal (16) d'écoulement, la longueur étant adaptée pour que l'extrémité libre du canal (16) d'écoulement puisse permettre une délivrance par perméation sub- linguale et/ou para-gingivale, le contenant étant tenu à la main.1. Container (10) for the preparation and / or administration of a very small volume of active ingredients in liquid form comprising a head (12) adapted to take a first storage position P1 in which said head (12) is in a distal position with respect to the container (10) and a second position of administration P2 in which said head (12) is in a position proximal to the container (10), this head (12) comprising a cannula (14), with at least one flow channel (16), the length being adapted so that the free end of the flow channel (16) can allow for sub-lingual and / or para-gingival permeation delivery, the container being held in the hand.
2. Contenant (10) pour la préparation et/ou l'administration d'un très faible volume de principes actifs sous forme liquide selon la revendication 1, caractérisé en ce qu'il comprend des moyens (26) de déplacement en translation de la tête (12), ces moyens comportant un ensemble pas de vis (30) porté par ledit contenant 10, et un filetage (34) de profil conjugué du pas de vis du contenant porté par la tête (12) de façon à coopérer par vissage.2. Container (10) for the preparation and / or administration of a very small volume of active ingredients in liquid form according to claim 1, characterized in that it comprises means (26) for translational movement of the head (12), these means comprising a set of screws (30) carried by said container 10, and a thread (34) of conjugated profile of the screw thread of the container carried by the head (12) so as to cooperate by screwing .
3. Contenant (10) pour la préparation et/ou l'administration d'un très faible volume de principes actifs sous forme liquide selon la revendication 1 ou 2, caractérisé en ce qu'il comprend des moyens (28) de verrouillage de sécurité de façon à interdire tout déplacement involontaire, en translation, de la tête (12) par rapport au contenant (10).3. Container (10) for the preparation and / or the administration of a very small volume of active principles in liquid form according to claim 1 or 2, characterized in that it comprises means (28) of security lock so as to prevent any involuntary displacement, in translation, of the head (12) relative to the container (10).
4. Contenant (10) pour la préparation et/ou l'administration d'un très faible volume de principes actifs sous forme liquide selon la revendication 3, caractérisé en ce que les moyens (28) de verrouillage comprennent une bague (36) amovible, interposée entre la tête (12) en position distale et le contenant (10). 4. Container (10) for the preparation and / or administration of a very small volume of active ingredients in liquid form according to claim 3, characterized in that the means (28) for locking comprise a ring (36) removable interposed between the head (12) distally and the container (10).
5. Contenant (10) pour la préparation et/ou l'administration d'un très faible volume de principes actifs sous forme liquide selon l'une quelconque des revendications précédentes, caractérisé en ce que la canule (14) est munie d'un couvre embout buccal (22) de sécurité, ruptable.5. Container (10) for the preparation and / or administration of a very small volume of active principles in liquid form according to any one of the preceding claims, characterized in that the cannula (14) is provided with a mouthpiece cover (22) safety, breakable.
6. Contenant (10) pour la préparation et/ou l'administration d'un très faible volume de principes actifs sous forme liquide selon l'une quelconque des revendications précédentes, caractérisé en ce qu'il comprend un col (32) et en ce que l'ouverture de ce col est munie d'un opercule (40) étanche.6. Container (10) for the preparation and / or administration of a very small volume of active principles in liquid form according to any one of the preceding claims, characterized in that it comprises a neck (32) and in the opening of this neck is provided with a seal (40) sealed.
7. Contenant (10) pour la préparation et/ou l'administration d'un très faible volume de principes actifs sous forme liquide selon l'une quelconque des précédentes revendications, caractérisé en ce qu'il comprend au moins deux compartiments (52), chaque compartiment étant séparé par un opercule (54) étanche.7. Container (10) for the preparation and / or administration of a very small volume of active principles in liquid form according to any one of the preceding claims, characterized in that it comprises at least two compartments (52) each compartment being separated by a sealed cover (54).
8. Contenant (10) pour la préparation et/ou l'administration d'un très faible volume de principes actifs sous forme liquide selon la revendication 7, caractérisé en ce que chaque compartiment (52) contient au moins un principe actif, un excipient, une substance antigénique et/ou un solvant.8. Container (10) for the preparation and / or administration of a very small volume of active ingredients in liquid form according to claim 7, characterized in that each compartment (52) contains at least one active ingredient, an excipient , an antigenic substance and / or a solvent.
9. Contenant (10) pour la préparation et/ou l'administration d'un très faible volume de principes actifs sous forme liquide selon l'une des revendications 6 à 8, caractérisé en ce qu'il comprend des moyens (24) de perforation du ou des opercule(s) 40 et/ou 54.9. Container (10) for the preparation and / or administration of a very small volume of active principles in liquid form according to one of claims 6 to 8, characterized in that it comprises means (24) of perforation of the lid (s) 40 and / or 54.
10. Contenant (10) pour la préparation et/ou l'administration d'un très faible volume de principes actifs sous forme liquide selon la revendication 9, caractérisé en ce les moyens (24) de perforation sont disposés en pied de canule (14).10. Container (10) for the preparation and / or administration of a very small volume of active ingredients in liquid form according to claim 9, characterized in that the means (24) for perforation are arranged at the bottom of the cannula (14). ).
11. Contenant (10) pour la préparation et/ou l'administration d'un très faible volume de principes actifs sous forme liquide selon l'une des revendications 7 ou 8, caractérisé en ce que les moyens (24) de perforation sont disposés en pied de canule (14) et/ou en contiguité de compartiments (52) de façon à pouvoir obtenir des mélanges des substances contenues dans lesdits compartiments dans un ordre déterminé.11. Container (10) for the preparation and / or administration of a very small volume of active ingredients in liquid form according to one of claims 7 or 8, characterized in that the means (24) of perforation are arranged at the foot of the cannula (14) and / or in contiguity of compartments (52) so as to obtain mixtures of the substances contained in said compartments in a determined order.
12. Contenant (10) pour la préparation et/ou l'administration d'un très faible volume de principes actifs sous forme liquide selon l'une des précédentes revendications, caractérisé en ce que la tête (12) comprend un principe actif, une substance antigénique, un excipient et/ou un solvant.12. Container (10) for the preparation and / or administration of a very small volume of active ingredients in liquid form according to one of the preceding claims, characterized in that the head (12) comprises an active principle, a antigenic substance, an excipient and / or a solvent.
13. Contenant (10) pour la préparation et/ou l'administration d'un très faible volume de principes actifs sous forme liquide selon l'une quelconque des revendications précédentes, caractérisé en ce qu'il comprend une palette (46) de préhension, disposée en partie inférieure du corps du contenant (10) de façon à permettre une bonne saisie en pince bidigitale.13. Container (10) for the preparation and / or administration of a very small volume of active ingredients in liquid form according to any one of the preceding claims, characterized in that it comprises a pallet (46) gripping disposed in the lower part of the body of the container (10) so as to allow a good grip bidigitale clamp.
14. Contenant (10) pour la préparation et/ou l'administration d'un très faible volume de principes actifs sous forme liquide selon l'une quelconque des revendications précédentes, caractérisé en ce que la tête (12) comporte sur sa surface extérieure périphérique des moyens (48) de préhension.14. Container (10) for the preparation and / or administration of a very small volume of active ingredients in liquid form according to any one of the preceding claims, characterized in that the head (12) has on its outer surface peripheral means (48) for gripping.
15. Contenant (10) pour la préparation et/ou l'administration d'un très faible volume de principes actifs sous forme liquide selon l'une quelconque des revendications précédentes, caractérisé en ce qu'il est adapté pour l'administration de principes actifs et/ou substances antigéniques à des fins de traitement pharmaceutique, homéopathique et/ou de désensibilisation allergique.15. Container (10) for the preparation and / or administration of a very small volume of active principles in liquid form according to any one of the preceding claims, characterized in that it is suitable for the administration of principles active and / or antigenic substances for pharmaceutical, homeopathic and / or allergic desensitization purposes.
16. Contenant (10) pour la préparation et/ou l'administration d'un très faible volume de principes actifs sous forme liquide selon la revendication 15, caractérisé en ce qu'il est adapté pour une administration per-muqueuse. 16. Container (10) for the preparation and / or administration of a very small volume of active ingredients in liquid form according to claim 15, characterized in that it is suitable for per mucosal administration.
EP08826867.7A 2007-07-20 2008-07-18 Device for packaging and sublingual administration of active principles Not-in-force EP2182908B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL08826867T PL2182908T3 (en) 2007-07-20 2008-07-18 Device for packaging and sublingual administration of active principles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0705290A FR2918874B1 (en) 2007-07-20 2007-07-20 DEVICE FOR CONDITIONING AND ADMINISTERING SUB-LINGUAL OF ACTIVE PRINCIPLES
PCT/FR2008/051368 WO2009016309A2 (en) 2007-07-20 2008-07-18 Device for packaging and sublingual administration of active principles

Publications (2)

Publication Number Publication Date
EP2182908A2 true EP2182908A2 (en) 2010-05-12
EP2182908B1 EP2182908B1 (en) 2016-01-06

Family

ID=39144520

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08826867.7A Not-in-force EP2182908B1 (en) 2007-07-20 2008-07-18 Device for packaging and sublingual administration of active principles

Country Status (13)

Country Link
US (1) US8376988B2 (en)
EP (1) EP2182908B1 (en)
JP (1) JP5912252B2 (en)
CN (1) CN101742984B (en)
BR (1) BRPI0812990A2 (en)
DK (1) DK2182908T3 (en)
ES (1) ES2562667T3 (en)
FR (1) FR2918874B1 (en)
HU (1) HUE028682T2 (en)
PL (1) PL2182908T3 (en)
PT (1) PT2182908E (en)
RU (1) RU2471474C2 (en)
WO (1) WO2009016309A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2938243B1 (en) * 2008-11-12 2013-08-23 Soc D Thermoformage Et D Injection Des Plastics DEVICE FOR PRESERVING AND RELEASING A PRODUCT CONTAINED IN A RESERVOIR COMPRISING A BREAKABLE WALL
FR2940911B1 (en) * 2009-01-13 2012-09-21 Philippe Perovitch FORMULATION FOR ORAL TRANSMUCOSAL ADMINISTRATION OF ANTALGIC AND / OR ANTI-SPASMODIC MOLECULES
IT1393560B1 (en) * 2009-01-21 2012-04-27 Lameplast Spa CONTAINER FOR FLUID PRODUCTS, PARTICULARLY PHARMACEUTICAL, COSMETIC, MEDICAL OR SIMILAR PRODUCTS
JP2012071862A (en) * 2010-09-28 2012-04-12 Dainippon Printing Co Ltd Cap with opening blade
FR2967894B1 (en) * 2010-11-30 2013-11-29 Philippe Perovitch DEVICE FOR PACKAGING, PRESERVING AND EXTENDING PREPARATION OF ONE OR MORE ACTIVE PRINCIPLES (S).
US9688434B2 (en) * 2012-08-17 2017-06-27 Archon Pharmaceutical Consulting Llc System for compounding and packaging ready to reconstitute ophthalmic drug powders to a solution or to a suspension for administration to an eye of patient
FR3000896B1 (en) 2013-01-14 2016-08-26 Philippe Perovitch GALENIC FORM FOR ADMINISTRATION OF ACTIVE INGREDIENT (S) FOR ACCELERATED INDUCTION OF SLEEP AND / OR TREATMENT OF SLEEP DISORDERS
FR3031668A1 (en) 2015-01-20 2016-07-22 Philippe Perovitch DEVICE FOR DELIVERY OF ACTIVE PRINCIPLE BY PERMUCOSAL MOUTH.
DK3795208T3 (en) 2015-03-18 2023-12-11 Abiomed Europe Gmbh BLOOD PUMP
US10624817B2 (en) 2015-03-24 2020-04-21 Neomed, Inc. Oral administration coupler for back-of-mouth delivery
FR3053244A1 (en) 2016-07-01 2018-01-05 Philippe Perovitch DEVICE FOR DELIVERY OF AT LEAST ONE ACTIVE PRINCIPLE BY PERMUCOSAL MOUTH.
FR3059895A1 (en) * 2016-12-12 2018-06-15 Stickdose DEVICE FOR DELIVERY OF AT LEAST ONE ACTIVE PRINCIPLE BY PERMUCOSAL MOUTH.
CA3053152A1 (en) 2017-02-13 2018-08-16 Aurelie De Malibran-Santibanez Liquid applicator for delivering vaccines
DE102017002401A1 (en) * 2017-03-07 2018-09-13 Kocher-Plastik Maschinenbau Gmbh Plastic container product
US10640275B2 (en) * 2017-06-12 2020-05-05 Bio-Techne Corportion Dual chamber storage device
US11607508B1 (en) 2020-12-23 2023-03-21 Stat Capsule Inc. Device for sublingual application of a therapeutic dose of medication in fractions
CN115154051B (en) * 2022-08-09 2023-03-31 杭州市西溪医院 Medical cotton swab for navel cleaning and disinfection
US11925748B1 (en) * 2023-06-08 2024-03-12 Microneb Tech Holdings, Inc. Apparatus, methods, and systems for administering a medication to a patient from a capsule using an atomizer

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR800987A (en) * 1936-01-06 1936-07-23 Unblocker-dispenser adaptable to containers such as collapsible tubes
US2754590A (en) * 1954-09-20 1956-07-17 Cohen Milton Joseph Container for toothache remedy
US3802604A (en) * 1972-02-28 1974-04-09 Oreal Device for storing two products separately and dispensing them simultaneously
IT1185850B (en) * 1985-08-02 1987-11-18 Zambon Spa DROP TANK CAP FOR BOTTLES
CH669575A5 (en) * 1985-08-20 1989-03-31 Alfatechnic Ag
US4648532A (en) * 1986-05-09 1987-03-10 Green Russell D Mixing and discharge capsule
FR2622546B2 (en) * 1987-05-25 1990-03-16 Emballages Conseils Etudes CLOSING DEVICE FOR CONTAINERS
US5176293A (en) * 1990-03-09 1993-01-05 Automatic Liquid Packaging, Inc. Dispenser with removable unitary cap and threadable overcap
DE4219103A1 (en) * 1992-06-11 1993-12-16 Cebal Verpackungen Tubular container with neck contg. perforatable diaphragm and closure - which consists of compression part, sealing fastener on neck and foldable cuff with connecting points, all being sealed
GB9405590D0 (en) 1994-03-22 1994-05-11 Celsis Ltd Assay device
US6001347A (en) * 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
WO1997025024A1 (en) * 1996-01-12 1997-07-17 Ohta Pharmaceutical Co., Ltd. Jellied medicinal composition for oral administration
US6202897B1 (en) * 1998-08-25 2001-03-20 3M Innovative Properties Company Unit dose liquid dispensing and packaging for dental application
US6328715B1 (en) * 1999-09-21 2001-12-11 William B. Dragan Unit dose low viscosity material dispensing system
FR2816600B1 (en) * 2000-11-13 2003-03-21 Michel Faurie DISPENSING DEVICE FOR DROP FLUID LIQUIDS
ATE377563T1 (en) * 2003-07-11 2007-11-15 Rodriguez Jose Luis Galaz CONTAINER FOR STORING AND MIXING TWO DIFFERENT SEPARATE PRODUCTS

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2009016309A2 *

Also Published As

Publication number Publication date
CN101742984A (en) 2010-06-16
PL2182908T3 (en) 2016-06-30
JP5912252B2 (en) 2016-04-27
PT2182908E (en) 2016-03-31
FR2918874B1 (en) 2009-10-09
RU2010106050A (en) 2011-08-27
DK2182908T3 (en) 2016-03-21
US20100198147A1 (en) 2010-08-05
FR2918874A1 (en) 2009-01-23
WO2009016309A3 (en) 2009-04-09
RU2471474C2 (en) 2013-01-10
EP2182908B1 (en) 2016-01-06
WO2009016309A2 (en) 2009-02-05
US8376988B2 (en) 2013-02-19
JP2010534081A (en) 2010-11-04
CN101742984B (en) 2014-06-25
ES2562667T3 (en) 2016-03-07
BRPI0812990A2 (en) 2014-12-16
HUE028682T2 (en) 2016-12-28

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