EP2182908B1 - Device for packaging and sublingual administration of active principles - Google Patents
Device for packaging and sublingual administration of active principles Download PDFInfo
- Publication number
- EP2182908B1 EP2182908B1 EP08826867.7A EP08826867A EP2182908B1 EP 2182908 B1 EP2182908 B1 EP 2182908B1 EP 08826867 A EP08826867 A EP 08826867A EP 2182908 B1 EP2182908 B1 EP 2182908B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- container
- head
- cannula
- operculum
- neck
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Not-in-force
Links
- 238000004806 packaging method and process Methods 0.000 title description 10
- 239000000126 substance Substances 0.000 claims description 22
- 230000001476 alcoholic effect Effects 0.000 claims description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 238000000586 desensitisation Methods 0.000 claims description 3
- 230000001632 homeopathic effect Effects 0.000 claims description 3
- 238000011282 treatment Methods 0.000 claims description 3
- 230000000295 complement effect Effects 0.000 claims description 2
- 230000002093 peripheral effect Effects 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 238000010079 rubber tapping Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 description 10
- 239000004480 active ingredient Substances 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 239000000463 material Substances 0.000 description 6
- 230000000890 antigenic effect Effects 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000011521 glass Substances 0.000 description 5
- 238000006073 displacement reaction Methods 0.000 description 4
- 230000003750 conditioning effect Effects 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000000172 allergic effect Effects 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- -1 lyoc Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000003094 microcapsule Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000004500 asepsis Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 238000002788 crimping Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 238000007391 self-medication Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 238000004078 waterproofing Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D51/00—Closures not otherwise provided for
- B65D51/18—Arrangements of closures with protective outer cap-like covers or of two or more co-operating closures
- B65D51/20—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing
- B65D51/22—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure
- B65D51/221—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure a major part of the inner closure being left inside the container after the opening
- B65D51/226—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure a major part of the inner closure being left inside the container after the opening the piercing or cutting means being non integral with, or not fixedly attached to, the outer closure
- B65D51/227—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure a major part of the inner closure being left inside the container after the opening the piercing or cutting means being non integral with, or not fixedly attached to, the outer closure and further comprising a device first inhibiting displacement of the piercing or cutting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/06—Ampoules or carpules
- A61J1/067—Flexible ampoules, the contents of which are expelled by squeezing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1412—Containers with closing means, e.g. caps
- A61J1/1418—Threaded type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/18—Arrangements for indicating condition of container contents, e.g. sterile condition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/0015—Devices specially adapted for taking medicines
- A61J7/0046—Cups, bottles or bags
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D47/00—Closures with filling and discharging, or with discharging, devices
- B65D47/36—Closures with frangible parts adapted to be pierced, torn, or removed, to provide discharge openings
- B65D47/38—Closures with frangible parts adapted to be pierced, torn, or removed, to provide discharge openings with piercing means arranged to act subsequently as a valve to control the opening
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1468—Containers characterised by specific material properties
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2251/00—Details relating to container closures
- B65D2251/0003—Two or more closures
- B65D2251/0006—Upper closure
- B65D2251/0025—Upper closure of the 47-type
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2251/00—Details relating to container closures
- B65D2251/0003—Two or more closures
- B65D2251/0068—Lower closure
- B65D2251/0093—Membrane
- B65D2251/0096—Membrane integral with the container
Definitions
- the present invention relates to a device for conditioning and administration of mucous active ingredients.
- the active ingredients dissolved in solution must be packaged in single doses, said conditioning must also allow a per-mucous administration either sub-lingual or para-gingival.
- a first constraint is the extremely small volume of the dose to be administered, of the order of 0.25 ml to 2 ml to give an order of magnitude.
- the solution is also fragile with regard to light and / or air with oxidation phenomena and sensitive to evaporation phenomena.
- This solution can also be the subject of adsorption or ionization phenomena at contact with the walls of the container, hence the need to resort to inert and particularly protective materials.
- the solution in particular in the case of alcoholic solutions, must maintain its alcohol content and constant dissolution stability of the conditioned active ingredient (s), which parameters are adapted for optimized permeation.
- the alcoholic degree is adjusted to retain the active ingredients themselves.
- the present invention provides a container for the preparation and / or administration of a very small volume of active ingredients in liquid form comprising a head capable of taking a first storage position in which said head is distal to the container and a second delivery position in which said head is proximal to the container, said head having a cannula, with at least one flow channel, the length being adapted to that the free end of the flow channel may allow sub-lingual and / or para-gingival permeation, the container being held by hand.
- Very low volume means a volume to be administered between 0.1 and 5 ml.
- This device is particularly suitable for the preparation and administration of active principles and / or antigenic substances for the purpose of pharmaceutical treatment, homeopathic and / or allergic desensitization.
- a container 10 which can be in any material avoiding evaporation through the wall and able to avoid the action of light on the contents.
- Such a container may be made of any material suitable for the packaged substances and the intended applications, such as glass, metal, plasma or a combination of these materials.
- the container is preferably glass, preferably thick glass, opacified, pharmaceutical grade, with high mechanical strength, square, oval, rectangular, triangular or round.
- This container 10 comprises a head 12 secured at least in translation relative to said container.
- This head is able to take a first position P1 of preservation in which said head 12 is distal to the container 10 and a second position of administration P2 in which said head 12 is in a position proximal to the container 10.
- the head 12 comprises a cannula 14, with at least one flow channel 16.
- the length is adapted so that the free end of the flow channel 16 can be housed in particular under the user's language or para-gingival, the container being held by hand.
- the cannula 14 further comprises the flow channel 16, at least one air intake 18, for example a second channel 20.
- This second channel 20 may be coaxial and external or juxtaposed with the first channel 16 for example.
- the air intake can also be effected by the same first channel, according to its diameter, the liquid solution being a solution based on alcohol, so very low viscosity.
- This cannula 14 has at its free end a mouthpiece cover 22.
- This mouthpiece cover 22 is a sealed safety cap for example sealed and breakable by rotation for the best mode, or by traction or cutting.
- the cannula 14 is integral with the head 12 and advantageously come from manufacture with said head.
- the material may be a suitable polymeric material.
- the cannula 14 comprises at the bottom 24 perforation means.
- the container 10 and the head 12 are equipped with means 26 for translational movement of said head 12 from the distal position to the proximal position.
- the container is also provided with safety locking means 28 so as to prevent any involuntary displacement, in translation, of the head 12 relative to the container 10.
- the translational displacement means 26 comprise a set of screws 30 carried by the container 10, more particularly by the neck 32 of this container and a thread 34 of the conjugate profile of the thread of the container carried. by the head 12 so as to cooperate by screwing.
- the locking means 28 comprise a removable ring 36 interposed between the head 12 in a distal position and the container 10, more particularly the shoulder 38 of this container when it is provided with it, as shown in the embodiment of the invention. figures 1 and 2 .
- This ring 36 has a C profile which is elastically mounted on the thread 30 carried by the container 10, prohibiting the translational movement of the head 12 relative to the container 10.
- the opening of the neck 32 of the container 10 is provided with a seal 40 which is tight and capable of being perforated by the perforation means 24.
- the head 12 comprises means 42 of total flow.
- These flow means 42 comprise, in part internally, a conical bottom, the cannula 14 being provided, in addition to the means 24 for perforation, with holes 44 of passage, arranged immediately upstream of the bottom with respect to the direction of flow, in connection with the flow channel 16.
- the perforation means 24 comprise only a tip.
- the ring 36 is disposed on the neck, around the screw thread 30, then the head 12 is attached by screwing until it comes into abutment on the ring 36.
- the mouthpiece cover 22 is in place on the cannula 14, closing the flow channel 16 and the channel 20 of the air intake 18.
- the packaging is not usable and can be preserved, without altering the content and without risk of accessibility to young children.
- the withdrawal of the mouthpiece 22 before reversal, for example by rotation causing the disassociation of this tip, allows to deliver the composition by the end of the cannula 14 positioned under the tongue or between the gum and the tongue or between the plays and the gum, the length of the cannula 14 being adapted for this purpose.
- composition is dispensed exactly where the efficiency is optimal, this for the entire volume contained.
- the air intake ensures a rapid distribution of the volume, which even low must be dispensed in a very short time, of the order of one second to give an order of magnitude.
- the internal diameter of the flow channel 16 must be relatively large, of the order of 2 millimeters for the amounts mentioned above, between 0.25 and 2 ml. This proportionally large diameter can also ensure the return of air to facilitate rapid flow.
- the displacement means incorporate a ferrule which is directly fixedly attached to said neck of the container, for example by crimping, said ferrule carrying the screw thread 30 necessary to cooperate with the thread 34 of the head 12.
- the glass container is filled with the composition and then capped. Then, the ferrule is attached to the neck and crimped, then the ring 36 is positioned and the head 12 is put in place in turn.
- the user acts exactly as indicated above.
- the dimensions of the bottle have been maximized to reveal the details of constitution but it must be taken into account that a container of 0.25 to 2 ml is extremely small and difficult to manipulate.
- the present invention proposes an improvement to the container which consists of adding a pallet 46 for gripping, advantageously disposed in the lower part of the body of the container 10.
- This pallet 46 gripping allows a good grip bidigital, despite the small size of the container to allow the user to maneuver the head 12 in rotation.
- this head 12 may comprise on its outer peripheral surface 48 gripping means such as fins 50, shown in the drawings.
- the user is thus ready to maneuver by exerting a torque between the container 10 and the head 12.
- the pallet 46 has a further handling advantage after rotation of the head relative to the container and after withdrawal of the mouthpiece cover, that of allowing easy handling of the container ready for use to position the cannula 14 at the desired location.
- the ring 36 may be a plastic belt adapted to be torn or dessertie. To facilitate these belt removal operations, a prehensile external pull tab can be added to this belt. Similarly, the filling before laying the lid can be performed under an inert gas atmosphere to preserve the contents.
- the container 10 comprises at least two compartments 52, each compartment being separated by a sealed cover 54.
- Each compartment contains at least one active ingredient, an excipient, an antigenic substance and / or a solvent.
- the device also comprises perforation means 24 capable of tearing the or lids 40 and / or 54, arranged at the bottom of the cannula 14 so as to obtain mixtures of the substances in a determined order.
- the head 12 also contains an active principle, an excipient, an antigenic substance and / or a solvent, at the level of the cannula 14.
- the head 12 can also have several compartments separated by a cover 66.
- the substance contained in the head 12 can be in the form of powder, tablet, lyoc, liquid microcapsule, etc.
- the perforating means tear the lid (s) 40 and / or 54 and / or 66 allowing the substances contained in the head 12, in particular in the cannula 14, and in each compartment 52 to mix.
- the perforation means tear the membrane encapsulating said substance before perforating the or lids 40 and / or 54 and / or 66.
- the substance contained in the head 12 may also be in the form of a liquid contained in the cannula 14 of the head 12, as shown in FIG. figure 5 .
- the cannula 14 then comprises an upper part 56 enclosing the liquid sealed by a sealed cover 62, and a lower part 58, separated by a thread 60.
- a first rotation of the head 12 on the thread 30 leads the part 58 to tear the lid 40 which sealed the container 10.
- An additional rotation causes the stop portion 58 on the thread 30.
- the cannula 14 then rotates around the second thread 60, which allows tearing the l operculum 62 which sealed the cannula. The liquid of the head 12 is thus released and the substances that were separated can mix.
- container according to the invention with at least two compartments 52 and / or a head 12 containing one or more substances, are particularly suitable for active ingredients and unstable substances in solution.
- active ingredients and unstable substances in solution.
- lipophilic active principles which, although perfectly soluble in hydroalcoholic solutions, have unstable evolutions with risks of denaturation and formation of undesirable compounds.
- the container according to the invention makes it possible to protect the active principle, excipient and / or antigenic substance in the form of powder, lyoc, tablet, liquid microcapsule, etc., and to carry out an extemporaneous dissolution in a solvent just before the administration. It is thus possible for certain complex and mutable components to form a device with several separate compartments for a successive assembly of these different substances not compatible just before their administration, this in a determined order.
- the container according to the invention can be used for the preparation and / or the administration of active principles and / or antigenic substances for the purposes of pharmaceutical treatment, homeopathic and / or allergic desensitization, in particular by the transmucosal route.
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Hematology (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Description
La présente invention concerne un dispositif de conditionnement et d'administration per-muqueuse de principes actifs.The present invention relates to a device for conditioning and administration of mucous active ingredients.
Il existe des procédés de diffusion de principes actifs par perméation sublinguale et/ou para-gingivale qui offrent de nombreux avantages.There are methods of diffusion of active principles by sublingual and / or para-gingival permeation that offer many advantages.
En effet, ces procédés de diffusion permettent d'obtenir des actions beaucoup plus rapides, avec des dosages beaucoup plus faibles de principes actifs et de façon plus ciblée en éliminant de très nombreux effets secondaires. Ces effets secondaires sont notamment engendrés par le fait que les médicaments à administration par voie orale sont métabolisées par les différents organes digestifs avant de diffuser vers les cibles visées par les principes actifs.Indeed, these diffusion methods allow to obtain much faster actions, with much lower dosages of active ingredients and more targeted by eliminating many side effects. These side effects are notably caused by the fact that the drugs to be administered orally are metabolized by the various digestive organs before diffusing towards the targets targeted by the active ingredients.
Si cette voie d'administration per-muqueuse est particulièrement attractive, elle reste néanmoins liée à des contraintes auxquelles il convient de pallier pour en permettre une mise en oeuvre aisée par les patients.Although this mucosal administration route is particularly attractive, it nevertheless remains linked to constraints that must be overcome to allow easy implementation by patients.
Les principes actifs mis en solution, notamment mis en solution dans des solutions alcooliques, doivent être conditionnés en unidoses, ledit conditionnement devant aussi permettre une administration per-muqueuse soit sub-linguale soit para-gingivale.The active ingredients dissolved in solution, especially dissolved in alcoholic solutions, must be packaged in single doses, said conditioning must also allow a per-mucous administration either sub-lingual or para-gingival.
Une première contrainte est le volume extrêmement réduit de la dose à administrer, de l'ordre de 0,25 ml à 2 ml pour donner un ordre de grandeur.A first constraint is the extremely small volume of the dose to be administered, of the order of 0.25 ml to 2 ml to give an order of magnitude.
La solution est également fragile au regard de la lumière et/ou de l'air avec des phénomènes d'oxydation et sensible aux phénomènes d'évaporation. Cette solution peut aussi faire l'objet de phénomènes d'adsorption ou d'ionisation au contact des parois du contenant, d'où la nécessité de recourir à des matériaux inertes et particulièrement protecteurs.The solution is also fragile with regard to light and / or air with oxidation phenomena and sensitive to evaporation phenomena. This solution can also be the subject of adsorption or ionization phenomena at contact with the walls of the container, hence the need to resort to inert and particularly protective materials.
Or la solution notamment dans le cas de solutions alcooliques doit conserver son degré alcoolique et une stabilité de dissolution constante du ou des principes actifs conditionnés, paramètres qui sont adaptés pour une perméation optimisée. De plus, le degré alcoolique est ajusté pour conserver les principes actifs eux-mêmes.However, the solution, in particular in the case of alcoholic solutions, must maintain its alcohol content and constant dissolution stability of the conditioned active ingredient (s), which parameters are adapted for optimized permeation. In addition, the alcoholic degree is adjusted to retain the active ingredients themselves.
Il importe de conserver le degré alcoolique initialement prévu.It is important to maintain the alcoholic degree initially planned.
En outre, pour certaines substances pharmacologiques instables, leur mise en dissolution ne doit être pratiquée qu'extemporanément, au moment même de l'administration, faute de quoi ils seraient altérés, donc inactifs.In addition, for certain unstable pharmacological substances, their dissolution must be practiced only extemporaneously, at the very moment of administration, otherwise they would be altered, therefore inactive.
Une contrainte omniprésente pour un tel conditionnement unidose est le coût de fabrication qui doit être extrêmement réduit compte tenu du nombre de conditionnements à réaliser et du fait d'un usage unique par principe même. Son recyclage après usage doit également être favorisé. Néanmoins, le conditionnement doit conserver les impératifs de sécurité, d'asepsie, en plus de la praticité et de l'ergonomie recherchées, pour garantir une mise à disposition aisée en automédication. Divers dispositifs de conditionnement sont connus de
C'est pourquoi, selon la revendication 1, la présente invention vise un contenant pour la préparation et/ ou l'administration d'un très faible volume de principes actifs sous forme liquide comprenant une tête apte à prendre une première position de conservation dans laquelle ladite tête est en position distale par rapport au contenant et une seconde position d'administration dans laquelle ladite tête est en position proximale par rapport au contenant, cette tête comportant une canule, avec au moins un canal d'écoulement, la longueur étant adaptée pour que l'extrémité libre du canal d'écoulement puisse permettre une délivrance par perméation sub-linguale et/ou para-gingivale, le contenant étant tenu à la main.Therefore, according to claim 1, the present invention provides a container for the preparation and / or administration of a very small volume of active ingredients in liquid form comprising a head capable of taking a first storage position in which said head is distal to the container and a second delivery position in which said head is proximal to the container, said head having a cannula, with at least one flow channel, the length being adapted to that the free end of the flow channel may allow sub-lingual and / or para-gingival permeation, the container being held by hand.
Par très faible volume on entend un volume à administrer compris entre 0,1 et 5 ml.Very low volume means a volume to be administered between 0.1 and 5 ml.
Ce dispositif est particulièrement adapté à la préparation et l'administration de principes actifs et/ou de substances antigéniques à des fins de traitement pharmaceutique, homéopathique et/ou de désensibilisation allergique.This device is particularly suitable for the preparation and administration of active principles and / or antigenic substances for the purpose of pharmaceutical treatment, homeopathic and / or allergic desensitization.
Le conditionnement selon la présente invention est maintenant décrit en détail suivant un mode de réalisation particulier, non limitatif, en regard des dessins annexés, dessins sur lesquels les différentes figures représentent :
-
figure 1 : une vue en perspective latérale du conditionnement selon la présente invention, -
figure 2A : une vue en coupe d'un conditionnement, avant toute utilisation, prêt pour l'usage, -
figure 2B : une vue en coupe d'un conditionnement, après mise en oeuvre des différents moyens permettant son utilisation, prêt pour une administration thérapeutique immédiate, -
figure 3 : conditionnement avec une palette de préhension et de manipulation disposée en partie inférieure, -
figure 4 : une vue en coupe d'une variante de conditionnement, comprenant plusieurs compartiments, et -
figure 5A à 5C : un synoptique de fonctionnement d'une variante schématique du conditionnement selon la présente invention.
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figure 1 a side perspective view of the packaging according to the present invention, -
Figure 2A : a sectional view of a package, before use, ready for use, -
Figure 2B : a sectional view of a packaging, after implementation of the various means for its use, ready for immediate therapeutic administration, -
figure 3 : packaging with a handling and handling pallet arranged at the bottom, -
figure 4 : a sectional view of a packaging variant, comprising several compartments, and -
FIGS. 5A to 5C : a block diagram of a schematic variant of the packaging according to the present invention.
Sur la
Un tel contenant peut être réalisé en tout matériau adapté aux substances conditionnées et aux applications visées, tel que du verre, du métal, du plasmique ou une association de ces matériaux.Such a container may be made of any material suitable for the packaged substances and the intended applications, such as glass, metal, plasma or a combination of these materials.
Le contenant est avantageusement en verre, de préférence en verre épais, opacifié, de qualité pharmaceutique, avec une haute résistance mécanique, de section carrée, ovale, rectangulaire, triangulaire ou ronde.The container is preferably glass, preferably thick glass, opacified, pharmaceutical grade, with high mechanical strength, square, oval, rectangular, triangular or round.
Afin de rendre les dessins explicites, la proportion des échelles n'est volontairement pas respectée.In order to make the drawings explicit, the proportion of the scales is deliberately not respected.
Ce contenant 10 comprend une tête 12, solidarisée de façon mobile au moins en translation par rapport audit contenant.This
Cette tête est apte à prendre une première position P1 de conservation dans laquelle ladite tête 12 est en position distale par rapport au contenant 10 et une seconde position P2 d'administration dans laquelle ladite tête 12 est en position proximale par rapport au contenant 10.This head is able to take a first position P1 of preservation in which said
La tête 12 comporte une canule 14, avec au moins un canal 16 d'écoulement.The
La longueur est adaptée pour que l'extrémité libre du canal 16 d'écoulement puisse venir se loger notamment sous la langue de l'utilisateur ou en para-gingival, le contenant étant tenu à la main.The length is adapted so that the free end of the
La canule 14 comprend en plus du canal 16 d'écoulement, au moins une prise d'air 18, par exemple un second canal 20. Ce second canal 20 peut être coaxial et externe ou juxtaposé au premier canal 16 par exemple. La prise d'air peut aussi s'effectuer par le même premier canal, suivant son diamètre, la solution liquide étant une solution à base d'alcool, donc de très faible viscosité.The
Cette canule 14 comporte à son extrémité libre un couvre embout buccal 22. Ce couvre embout buccal 22 est un bouchon scellé de sécurité par exemple scellé et ruptable par rotation pour le meilleur mode, ou par traction ou par découpe.This
La canule 14 est solidaire de la tête 12 et avantageusement venue de fabrication avec ladite tête. Le matériau peut être une matière polymère adaptée.The
La canule 14 comprend en pied des moyens 24 de perforation.The
Le contenant 10 et la tête 12 sont équipés de moyens 26 de déplacement en translation de ladite tête 12 de la position distale à la position proximale.The
Le contenant est aussi muni de moyens 28 de verrouillage de sécurité de façon à interdire tout déplacement involontaire, en translation, de la tête 12 par rapport au contenant 10.The container is also provided with safety locking means 28 so as to prevent any involuntary displacement, in translation, of the
Dans le mode de réalisation préféré, les moyens 26 de déplacement en translation comprennent un ensemble pas de vis 30 porté par le contenant 10, plus particulièrement par le col 32 de ce contenant et un filetage 34 de profil conjugué du pas de vis du contenant porté par la tête 12 de façon à coopérer par vissage.In the preferred embodiment, the translational displacement means 26 comprise a set of
Les moyens 28 de verrouillage comprennent une bague 36 amovible, interposée entre la tête 12 en position distale et le contenant 10, plus particulièrement l'épaulement 38 de ce contenant lorsqu'il en est muni, ainsi que représenté sur le mode de réalisation des
Cette bague 36 a un profil en C qui vient se monter élastiquement sur le pas de vis 30 porté par le contenant 10, interdisant le mouvement en translation de la tête 12 par rapport à ce contenant 10.This
De façon complémentaire, l'ouverture du col 32 du contenant 10 est munie d'un opercule 40 étanche et apte à être perforé par les moyens 24 de perforation.In a complementary manner, the opening of the
De façon avantageuse, afin d'assurer une administration de l'intégralité de la composition médicamenteuse sous forme liquide, la tête 12 comprend des moyens 42 d'écoulement total. Ces moyens 42 d'écoulement comprennent, en partie interne, un fond conique, la canule 14 étant munie, en plus des moyens 24 de perforation, de trous 44 de passage, disposés immédiatement en amont du fond par rapport au sens d'écoulement, en liaison avec la canal 16 d'écoulement. Dans ce cas, les moyens 24 de perforation comprennent uniquement une pointe. Ainsi, le contenant 10 est empli de la composition médication sous forme liquide à administration per-muqueuse puis le contenant 10 est obturé de façon étanche par la pose de l'opercule 40 qui joue aussi le rôle de membrane d'étanchéité, surtout dans le cas d'une solution alcoolique.Advantageously, in order to ensure administration of the entire drug composition in liquid form, the
La bague 36 est disposée sur le col, autour du pas de vis 30, puis la tête 12 est rapportée par vissage jusqu'à venir en butée sur la bague 36.The
Le couvre embout buccal 22 est en place sur la canule 14, obturant le canal 16 d'écoulement et le canal 20 de la prise d'air 18.The
Dans cette position de conservation, le conditionnement n'est pas utilisable et peut être conservé, sans altération du contenu et sans risque d'accessibilité aux jeunes enfants.In this conservation position, the packaging is not usable and can be preserved, without altering the content and without risk of accessibility to young children.
Lorsque l'utilisateur souhaite s'administrer ou administrer la composition médicamenteuse, il lui suffit de retirer la bague 36 par simple traction puis de visser la tête 12.When the user wishes to administer or administer the drug composition, it suffices to remove the
Il se produit alors un déplacement en translation de ladite tête qui amène les moyens de perforation à déchirer l'opercule qui assurait le scellage, permettant au liquide de couler vers la canule lorsque le contenant est retourné.There then occurs a displacement in translation of said head which causes the perforating means to tear the lid which ensured the seal, allowing the liquid to flow to the cannula when the container is returned.
Le retrait de l'embout buccal 22 avant retournement, par exemple par rotation provoquant la désolidarisntion de cet embout, permet de délivrer la composition par l'extrémité de la canule 14 positionnée sous la langue ou entre la gencive et la langue ou encore entre la joue et la gencive, la longueur de la canule 14 étant adaptée à cet effet.The withdrawal of the
Ainsi, la composition est dispensée exactement à l'endroit où l'efficacité est optimale, ceci pour la totalité du volume contenu.Thus, the composition is dispensed exactly where the efficiency is optimal, this for the entire volume contained.
On note que la prise d'air assure une distribution rapide du volume, qui même faible doit être dispensé en un temps très court, de l'ordre de la seconde pour donner un ordre de grandeur.It is noted that the air intake ensures a rapid distribution of the volume, which even low must be dispensed in a very short time, of the order of one second to give an order of magnitude.
A cet effet, le diamètre interne du canal 16 d'écoulement doit être relativement important, de l'ordre de 2 millimètres pour les quantités mentionnées ci-avant, comprises entre 0,25 et 2 ml. Ce diamètre proportionnellement important peut aussi assurer la remontée d'air pour faciliter l'écoulement rapide.For this purpose, the internal diameter of the
Dans le cas d'un recours à un contenant du type flacon en verre épais, il est possible de recourir à un agencement particulier.In the case of using a container of the thick glass bottle type, it is possible to resort to a particular arrangement.
Soit le col porte un pas de vis 30 venu de fabrication avec le contenant, soit le col est lisse. Dans le cas d'un col lisse, les moyens de déplacement intègrent une virole qui est directement rapportée de façon fixe sur ledit col du contenant, par exemple par sertissage, ladite virole portant le pas de vis 30 nécessaire pour coopérer avec le filetage 34 de la tête 12.Either the neck carries a
Dans ce cas, le contenant en verre est empli de la composition puis operculé. Ensuite, la virole est rapportée sur le col et sertie, puis la bague 36 est positionnée puis la tête 12 est mise en place à son tour.In this case, the glass container is filled with the composition and then capped. Then, the ferrule is attached to the neck and crimped, then the
Pour l'utilisation, l'utilisateur agit exactement comme indiqué précédemment. Ainsi que cela vient d'être décrit, les dimensions du flacon on été maximisées pour permettre de faire apparaître les détails de constitution mais il faut prendre en compte le fait qu'un contenant de 0,25 à 2 ml est extrêmement petit et difficile à manipuler.For use, the user acts exactly as indicated above. As has just been described, the dimensions of the bottle have been maximized to reveal the details of constitution but it must be taken into account that a container of 0.25 to 2 ml is extremely small and difficult to manipulate.
Aussi la présente invention propose un perfectionnement au contenant qui consiste à adjoindre une palette 46 de préhension, disposée avantageusement en partie inférieure du corps du contenant 10.Also the present invention proposes an improvement to the container which consists of adding a
Cette palette 46 de préhension permet une bonne saisie en pince bidigitale, malgré la petitesse du contenant afin de permettre à l'utilisateur de manoeuvrer la tête 12 en rotation.This
De même, cette tête 12 peut comporter sur sa surface extérieure périphérique des moyens 48 de préhension comme des ailettes 50, représentées sur les dessins.Similarly, this
L'utilisateur est ainsi prêt à manoeuvrer en exerçant un couple entre le contenant 10 et la tête 12.The user is thus ready to maneuver by exerting a torque between the
On note aussi que la palette 46 de préhension présente un autre avantage de manipulation après rotation de la tête par rapport au contenant et après retrait du couvre embout buccal, celui d'autoriser une manipulation aisée du contenant prêt à l'usage pour positionner la canule 14 à l'endroit désiré.Note also that the
En variante, la bague 36 peut être une ceinture plastique apte à être déchirée ou dessertie. Afin de faciliter ces opérations de retrait de la ceinture, une languette externe préhensible de traction peut être adjointe à cette ceinture. De même le remplissage avant pose de l'opercule peut être réalisé sous atmosphère de gaz inerte pour préserver le contenu.Alternatively, the
Selon l'invention, comme représenté sur la
Chaque compartiment contient au moins un principe actif, un excipient, une substance antigénique et/ou un solvant.Each compartment contains at least one active ingredient, an excipient, an antigenic substance and / or a solvent.
Le dispositif comprend également des moyens 24 de perforation aptes à déchirer le ou les opercules 40 et/ou 54, disposés en pied de canule 14 de façon à pouvoir obtenir des mélanges des substances dans un ordre déterminé.The device also comprises perforation means 24 capable of tearing the or
Lorsque l'utilisateur souhaite s'administrer ou administrer la composition médicamenteuse, il retire la bague 36 par traction puis visse la tête 12. Il se produit alors un déplacement en translation de ladite tête qui amène les moyens de perforation à déchirer le ou les opercules 40 et/ou 54, permettant aux substances contenues dans chaque compartiment 52 de se mélanger pour obtenir un liquide qui coule vers la canule lorsque le contenant est retourné.When the user wishes to administer or administer the drug composition, he removes the
La tête 12 contient également un principe actif, un excipient, une substance antigénique et/ou un solvant, au niveau de la canule 14. La tête 12 peut également présenter plusieurs compartiments séparés par un opercule 66. La substance contenue dans la tête 12 peut se présenter sous forme de poudre, de comprimé, de lyoc, de microcapsule liquidienne, etc. Lorsque la tête se déplace en translation, les moyens de perforation déchirent le ou les opercules 40 et/ou 54 et/ou 66 permettant aux substances contenues dans la tête 12, notamment dans la canule 14, et dans chaque compartiment 52 de se mélanger. De même si la substance contenue dans la tête 12 est encapsulée, les moyens de perforation déchirent la membrane encapsulant ladite substance avant de perforer le ou les opercules 40 et/ou 54 et/ou 66.The
La substance contenue dans la tête 12 peut également se présenter sous forme d'un liquide contenu dans la canule 14 de la tête 12, comme représenté sur la
Ces formes de contenant selon l'invention avec au moins deux compartiments 52 et/ou une tête 12 contenant une ou plusieurs substances, sont particulièrement adaptées aux principes actifs et substances instables en solution. C'est le cas par exemple des principes actifs lipophiles, qui, bien que parfaitement solubles dans des solutions hydroalcooliques, présentent des évolutions instables avec des risques de dénaturation et de formation de composés indésirables.These forms of container according to the invention with at least two
Le contenant selon l'invention permet de protéger le principe actif, excipient et/ou substance antigénique sous forme de poudre, de lyoc, de comprimé, de microcapsule liquidienne, etc., et de réaliser une dissolution extemporanée dans un solvant juste avant l'administration. Il est ainsi possible pour certains composants complexes et altérables entre eux, de constituer un dispositif à plusieurs compartiments séparés permettant un assemblage successifs de ces différentes substances peu compatibles juste avant leur administration, ceci dans un ordre déterminé.The container according to the invention makes it possible to protect the active principle, excipient and / or antigenic substance in the form of powder, lyoc, tablet, liquid microcapsule, etc., and to carry out an extemporaneous dissolution in a solvent just before the administration. It is thus possible for certain complex and mutable components to form a device with several separate compartments for a successive assembly of these different substances not compatible just before their administration, this in a determined order.
Le contenant selon l'invention peut être utilisé pour la préparation et/ou l'administration de principes actifs et/ou de substances antigéniques à des fins de traitement pharmaceutique, homéopathique et/ou de désensibilisation allergique, notamment par voie trans-muqueuse.The container according to the invention can be used for the preparation and / or the administration of active principles and / or antigenic substances for the purposes of pharmaceutical treatment, homeopathic and / or allergic desensitization, in particular by the transmucosal route.
Claims (9)
- A single dose device for preparing and administering through the buccal mucous a volume of an alcoholic solution containing at least one lipophilic active principle, comprising a container (10), a head (12) suitable for taking up a conservation, first position P1 in which said head (12) is in a distal position relative to the container (10), and an administration, second position P2 in which said head (12) is in a proximal position relative to the container (10), said head (12) including a cannula (14) with at least one flow channel (16), its length being adapted so that the free end of the flow channel (16) can enable delivery by sublingual and/or paragingival permeation, while the container is being held in the hand, said device including at least two compartments (52; 56), separated by a leakproof operculum (40; 54; 62), each compartment (52; 56) containing at least an active principle and/or an excipient and/or an antigen substance and/or a solvent, said device including perforation means (24) for perforating the operculum(s) (40; 54; 62), said perforation means (24) being disposed at the root of the cannula (14) so as to enable the substances contained in said compartments to be mixed together in a determined order, the volume of said container being between 0,25 ml and 2 ml, characterized in that the cannula (14) contains before actuation an active principle, an antigen substance, an excipient and/or a solvent.
- A device according to claim 1, including movement means (26) for moving the head (12) in translation, these means comprising an assembly of a screw thread (30) carried by said container (10) and tapping (34) of profile complementary to the screw thread of the container and carried by the head (12) so as to cooperate by screw fastening.
- A device according to claim 1 or 2, including safety locking means (28) to prevent any unwanted movement in translation of the head (12) relative to the container (10).
- A device according to claim 3, wherein the locking means (28) comprise a removable ring (36) interposed between the head (12) in the distal position and the container (10).
- A device according to any preceding claim, wherein the cannula (14) is provided with a mouthpiece cover (22) for safety purposes that can be broken off.
- A device according to any preceding claim, including a neck (32), the opening of the neck being provided with a leakproof operculum (40).
- A device according to any preceding claim, including a gripper blade (46) located at the bottom portion of the body of the container (10) so as to enable it to be gripped securely between two fingers.
- A device according to any preceding claim, wherein the head (12) includes gripper means (48) on its peripheral outside surface.
- A device according to any preceding claim, wherein said container is suitable for administering active principles and/or antigen substances for the purposes of pharmaceutical, homeopathic, and/or allergy desensitization treatments.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL08826867T PL2182908T3 (en) | 2007-07-20 | 2008-07-18 | Device for packaging and sublingual administration of active principles |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0705290A FR2918874B1 (en) | 2007-07-20 | 2007-07-20 | DEVICE FOR CONDITIONING AND ADMINISTERING SUB-LINGUAL OF ACTIVE PRINCIPLES |
PCT/FR2008/051368 WO2009016309A2 (en) | 2007-07-20 | 2008-07-18 | Device for packaging and sublingual administration of active principles |
Publications (2)
Publication Number | Publication Date |
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EP2182908A2 EP2182908A2 (en) | 2010-05-12 |
EP2182908B1 true EP2182908B1 (en) | 2016-01-06 |
Family
ID=39144520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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EP08826867.7A Not-in-force EP2182908B1 (en) | 2007-07-20 | 2008-07-18 | Device for packaging and sublingual administration of active principles |
Country Status (13)
Country | Link |
---|---|
US (1) | US8376988B2 (en) |
EP (1) | EP2182908B1 (en) |
JP (1) | JP5912252B2 (en) |
CN (1) | CN101742984B (en) |
BR (1) | BRPI0812990A2 (en) |
DK (1) | DK2182908T3 (en) |
ES (1) | ES2562667T3 (en) |
FR (1) | FR2918874B1 (en) |
HU (1) | HUE028682T2 (en) |
PL (1) | PL2182908T3 (en) |
PT (1) | PT2182908E (en) |
RU (1) | RU2471474C2 (en) |
WO (1) | WO2009016309A2 (en) |
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FR2938243B1 (en) * | 2008-11-12 | 2013-08-23 | Soc D Thermoformage Et D Injection Des Plastics | DEVICE FOR PRESERVING AND RELEASING A PRODUCT CONTAINED IN A RESERVOIR COMPRISING A BREAKABLE WALL |
FR2940911B1 (en) | 2009-01-13 | 2012-09-21 | Philippe Perovitch | FORMULATION FOR ORAL TRANSMUCOSAL ADMINISTRATION OF ANTALGIC AND / OR ANTI-SPASMODIC MOLECULES |
IT1393560B1 (en) * | 2009-01-21 | 2012-04-27 | Lameplast Spa | CONTAINER FOR FLUID PRODUCTS, PARTICULARLY PHARMACEUTICAL, COSMETIC, MEDICAL OR SIMILAR PRODUCTS |
JP2012071862A (en) * | 2010-09-28 | 2012-04-12 | Dainippon Printing Co Ltd | Cap with opening blade |
FR2967894B1 (en) | 2010-11-30 | 2013-11-29 | Philippe Perovitch | DEVICE FOR PACKAGING, PRESERVING AND EXTENDING PREPARATION OF ONE OR MORE ACTIVE PRINCIPLES (S). |
US9688434B2 (en) * | 2012-08-17 | 2017-06-27 | Archon Pharmaceutical Consulting Llc | System for compounding and packaging ready to reconstitute ophthalmic drug powders to a solution or to a suspension for administration to an eye of patient |
FR3000896B1 (en) | 2013-01-14 | 2016-08-26 | Philippe Perovitch | GALENIC FORM FOR ADMINISTRATION OF ACTIVE INGREDIENT (S) FOR ACCELERATED INDUCTION OF SLEEP AND / OR TREATMENT OF SLEEP DISORDERS |
FR3031668A1 (en) | 2015-01-20 | 2016-07-22 | Philippe Perovitch | DEVICE FOR DELIVERY OF ACTIVE PRINCIPLE BY PERMUCOSAL MOUTH. |
DK3795208T3 (en) | 2015-03-18 | 2023-12-11 | Abiomed Europe Gmbh | BLOOD PUMP |
US10624817B2 (en) | 2015-03-24 | 2020-04-21 | Neomed, Inc. | Oral administration coupler for back-of-mouth delivery |
FR3053244A1 (en) | 2016-07-01 | 2018-01-05 | Philippe Perovitch | DEVICE FOR DELIVERY OF AT LEAST ONE ACTIVE PRINCIPLE BY PERMUCOSAL MOUTH. |
FR3059895A1 (en) * | 2016-12-12 | 2018-06-15 | Stickdose | DEVICE FOR DELIVERY OF AT LEAST ONE ACTIVE PRINCIPLE BY PERMUCOSAL MOUTH. |
MX2019009580A (en) * | 2017-02-13 | 2020-01-30 | Boehringer Ingelheim Animal Health Usa Inc | Liquid applicator for delivering vaccines. |
DE102017002401A1 (en) * | 2017-03-07 | 2018-09-13 | Kocher-Plastik Maschinenbau Gmbh | Plastic container product |
US10640275B2 (en) * | 2017-06-12 | 2020-05-05 | Bio-Techne Corportion | Dual chamber storage device |
US11607508B1 (en) | 2020-12-23 | 2023-03-21 | Stat Capsule Inc. | Device for sublingual application of a therapeutic dose of medication in fractions |
CN115154051B (en) * | 2022-08-09 | 2023-03-31 | 杭州市西溪医院 | Medical cotton swab for navel cleaning and disinfection |
US11925748B1 (en) * | 2023-06-08 | 2024-03-12 | Microneb Tech Holdings, Inc. | Apparatus, methods, and systems for administering a medication to a patient from a capsule using an atomizer |
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-
2008
- 2008-07-18 US US12/668,805 patent/US8376988B2/en not_active Expired - Fee Related
- 2008-07-18 RU RU2010106050/15A patent/RU2471474C2/en not_active IP Right Cessation
- 2008-07-18 BR BRPI0812990-8A2A patent/BRPI0812990A2/en not_active Application Discontinuation
- 2008-07-18 WO PCT/FR2008/051368 patent/WO2009016309A2/en active Application Filing
- 2008-07-18 CN CN200880024689.4A patent/CN101742984B/en not_active Expired - Fee Related
- 2008-07-18 EP EP08826867.7A patent/EP2182908B1/en not_active Not-in-force
- 2008-07-18 PT PT88268677T patent/PT2182908E/en unknown
- 2008-07-18 HU HUE08826867A patent/HUE028682T2/en unknown
- 2008-07-18 JP JP2010516559A patent/JP5912252B2/en active Active
- 2008-07-18 PL PL08826867T patent/PL2182908T3/en unknown
- 2008-07-18 DK DK08826867.7T patent/DK2182908T3/en active
- 2008-07-18 ES ES08826867.7T patent/ES2562667T3/en active Active
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US4648532A (en) * | 1986-05-09 | 1987-03-10 | Green Russell D | Mixing and discharge capsule |
Also Published As
Publication number | Publication date |
---|---|
JP2010534081A (en) | 2010-11-04 |
PL2182908T3 (en) | 2016-06-30 |
WO2009016309A3 (en) | 2009-04-09 |
JP5912252B2 (en) | 2016-04-27 |
FR2918874B1 (en) | 2009-10-09 |
CN101742984A (en) | 2010-06-16 |
ES2562667T3 (en) | 2016-03-07 |
US20100198147A1 (en) | 2010-08-05 |
EP2182908A2 (en) | 2010-05-12 |
PT2182908E (en) | 2016-03-31 |
DK2182908T3 (en) | 2016-03-21 |
HUE028682T2 (en) | 2016-12-28 |
RU2471474C2 (en) | 2013-01-10 |
FR2918874A1 (en) | 2009-01-23 |
RU2010106050A (en) | 2011-08-27 |
US8376988B2 (en) | 2013-02-19 |
CN101742984B (en) | 2014-06-25 |
BRPI0812990A2 (en) | 2014-12-16 |
WO2009016309A2 (en) | 2009-02-05 |
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