EP3247424A1 - Vorrichtung zur verabreichung eines wirkstoffes über die orale mukosale route - Google Patents
Vorrichtung zur verabreichung eines wirkstoffes über die orale mukosale routeInfo
- Publication number
- EP3247424A1 EP3247424A1 EP16705222.4A EP16705222A EP3247424A1 EP 3247424 A1 EP3247424 A1 EP 3247424A1 EP 16705222 A EP16705222 A EP 16705222A EP 3247424 A1 EP3247424 A1 EP 3247424A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- connector
- syringe body
- ampoule
- perforator
- syringe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/0015—Devices specially adapted for taking medicines
- A61J7/0053—Syringes, pipettes or oral dispensers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
- A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/1782—Devices aiding filling of syringes in situ
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
Definitions
- the present invention relates to a device for administering an active ingredient per oral mucosa, in particular a lipophilic active principle dissolved in a hydro-alcoholic solution consisting of water and ethanol.
- Suitable devices for preparing and dispensing these active principles have been described in WO2009016309, WO2009138644, WO2010063978 or WO2012072934.
- they must preferably be deposited completely and in a single action, preferably in the anatomical gingivochalal gutter, in order to ensure the absorption of these weak solutions. volume in a few seconds by this same mucous surface, so that following this administration, the active ingredient is instantly distributed in the central bloodstream and arterial.
- WO 2007/014955 discloses a glass ampoule with a single opening provided with a seal sealed on a circular rim, which cap may be defeated by traction on an external tab, said seal may also be pierced by a straw, which allows then to extract all the liquid easily by sucking it, as for a drink.
- aqueous-alcoholic solutions to be administered by the oral mucosa route, vectors of lipophilic active principles placed in solution have a very small volume, preferably less than 2 ml.
- a very small volume preferably less than 2 ml.
- the precise and complete deposit in the gingivo-juale gutter of the patient is difficult or impossible to obtain from the only manipulation of such a small bulb, whatever its conformation. Indeed, the liquid remains retained at the neck of the bulb that supports the sealing of the lid.
- the present invention aims to overcome the aforementioned drawbacks.
- the present invention is intended in particular to allow the easy operation of small volume sealed ampoules, in order to deliver medicinal aqueous solutions alcohol-per-oral mucosa.
- the present invention also aims to allow the exact measurement of the dosage of active ingredient to be administered and its instantaneous administration and without any loss.
- Another object of the present invention is to provide a device for administering an active ingredient by the oral mucosa route which, by its particular shape, protects the mucosal tissues of the gingivochalal gutter from any trauma or deterioration during this administration.
- Another object of the present invention is to provide a device for administering an oral mucosal active ingredient which is simple and inexpensive to manufacture and assemble, and reliable in use.
- the present invention therefore relates to a device for administering an active ingredient per oral mucosa, comprising:
- a ampoule containing a liquid said ampoule comprising a single opening defining a peripheral axial edge and closed by a lid,
- a syringe body provided with a dispensing orifice for dispensing said at least one active principle on the gingivo-jugal mucosae
- a piston contained in said syringe body, a piston rod connected to said piston for moving said piston in said syringe body,
- a connector formed of a piece with or attached to said syringe body, said connector being adapted to connect sealingly to said ampoule, said connector comprising an internal perforator for perforating said lid of said ampoule and connecting the inside of said ampoule with said syringe body, said internal perforator forming said dispensing orifice of the syringe body during the distribution of the active ingredient on said gingivo-jugal mucosa, said connector further comprising an external protective skirt to create a gingivo-jugal cavity in spreading the jute mucosa of the gingival mucosa during the time of deposition and complete absorption of said liquid, said outer protective skirt surrounding said internal perforator, and said connector having an annular receiving space for receiving said peripheral axial edge of said ampoule, said annular receiving space being defined between said perforation internal frame and said outer protective skirt.
- said syringe body and said connector are integrally formed.
- said syringe body and said connector are separately formed, said connector having attachment means for securing said connector to said syringe body.
- said fixing means comprise screwing or latching means.
- said fixing means comprise locking means, such as a groove, which ensure a firm attachment of said connector on said syringe body.
- said perforator has a blunt end and non-aggressive.
- said outer protective skirt has a rounded outer shape, in particular hemispherical.
- said syringe body has graduations, allowing accurate dosing, especially 0.01 ml.
- said syringe body comprises a lockable movable slider, thus making it possible to determine a benchmark of the reference dosage to be administered.
- said ampoule contains a hydroalcoholic solution consisting of water and ethanol, with preferably 40% to 60% ethanol and 60% to 40% water.
- said ampoule contains an active ingredient dissolved in said hydro-alcoholic solution.
- the volume of said ampoule is between 0.5 ml and 2 ml.
- FIG. 1 is an exploded view of a device for administering an active ingredient by the oral mucosa route according to a first advantageous embodiment of the invention
- FIG. 2 is a view similar to that of FIG. 1, showing a second advantageous embodiment of the invention
- FIG. 3 is a detailed perspective view of a sealed ampoule
- FIG. 4 is a detail view, in cut-away perspective, of the connector of FIG. 3, according to a first advantageous embodiment of the invention
- FIG. 5 is a view similar to that of FIG. 4, showing a second advantageous embodiment of the connector
- FIG. 6 is a diagrammatic cross-sectional view of the connector of FIG. 4;
- FIG. 7 is a diagrammatic cross-sectional view of the connector of FIG. 5,
- FIG. 8 is a three-quarter perspective view below of a connector according to the second embodiment of the invention of FIG. 2, - Figures 9 to 12 are schematic views illustrating other embodiments.
- Figures 1 to 3 show the delivery device in the upright position, with the syringe above the ampoule. However, it is understood that in use, when the user draws the product contained in the ampoule to transfer it into the syringe, it is preferable that the administration device is in the inverted position, with the ampoule above the syringe, to avoid aspiration of air.
- the present invention applies more particularly to active ingredients of lipophilic nature dissolved in an aqueous-alcoholic solution.
- This hydroalcoholic solution is preferably composed exclusively of water and ethanol.
- the hydroalcoholic solution comprises from 40% to 60% by volume of ethanol and from 60% to 40% by volume of water.
- the device comprises four components: a sealed ampoule 1, whose volume is preferably between 0.5 ml and 2 ml, a syringe body 2, a piston 3, and an actuating rod 4 cooperating with said piston 3 to slide it sealingly into said syringe body 2.
- said piston 3 may be formed of a seal positioned at the end of said actuating rod 4.
- the ampoule 1, visible in Figure 3, has a single opening defining a peripheral axial edge 1 1, said opening being closed by a cap 10.
- Said seal 10 is perforable and preferably non-peelable.
- the end 12 of the ampoule 1 opposite to said operculum 1 1, typically in the form of a tapered tail of the bulb, is advantageously free, and may optionally be held by the user of the device while it inserts said ampoule 1 into the connector 20 of the syringe body 2 described below.
- the syringe body 2 comprises on one side a connector 20 adapted to connect to said bulb 1, and on the other side a radial flange 29 forming a finger rest during actuation.
- said connector 20 is formed of a one-piece piece with said syringe body.
- the syringe body 2 further comprises graduations for a very accurate dosage, especially 0.01 ml, which allows to adjust with great precision the dosage of the active ingredient administered relative to the desired therapeutic action.
- said syringe is specifically graduated for the exclusive use of the determination of a single active principle in hydro-alcoholic solution to be administered gingivo-juale.
- the precise dosage to be administered gingivochalally can be taken from said sealed ampoule and adjusted to at least one fiftieth of a milliliter.
- a movable slider 200 around the graduation of the syringe.
- This slider 200 is preferably lockable in a fixed manner, which allows to mark the precise dosage to be administered or not to be exceeded, so that the user respects the dosages determined for each take.
- the lock of the slider 200 can for example be achieved with an external clamping screw 210, as shown schematically in FIG. 10.
- the slider 200 can be slidable on a lateral rail 220 integral with the syringe 2 or the connector 20, the slider 200 locking on notches of stops 225 present on the side rail 220. These notches 225 may for example be stair-type, square, or holes in which the slider 200 clips.
- the slider can simply slide with friction on the syringe body.
- Said connector 20 comprises an internal perforator 23 for perforating said cap 10 of said ampoule and thus connecting the inside of said ampoule 1 with said syringe body 2.
- Said internal perforator 23 comprises a channel 25 and forms the dispensing orifice of the body syringe 2 during the distribution of the active ingredient on said gingivo-jugal mucosa.
- Said connector 20 further comprises an outer protective skirt 21 surrounding said internal perforator 23. This protective skirt 21 surrounds said internal perforator 23, and advantageously comprises a rounded outer shape, particularly hemispherical, to avoid any risk of injury when it comes into contact of the gingivo-jugale gutter.
- This rounded shape makes it possible in particular to move the cheek of the patient away from the gingiva, and thus to maintain said gap forming an enlarged channel during the flow of the hydro-alcoholic solution of the active ingredient in said gingivo-juar gutter, in preventing any traumatic or irritating involvement of said mucosal anatomical cavity.
- the present invention makes it possible, after an exact duly measured sampling of the hydroalcoholic solution from the ampoule 1, to remove the mucous membrane of the gingival mucosa with the aid of the connector 20 in order to temporarily create the mucous receptacle cavity of this mucous membrane. hydro-alcoholic deposit, to allow its deposit and absorption.
- the dimensions of the connector 20 can be adapted for administration to small children.
- the connector 20 also comprises an annular receiving space 24 for receiving, advantageously sealingly, the peripheral axial edge 1 1 of the bulb 1, said annular receiving space 24 being defined between said internal perforator 23 and said outer protective skirt 21 .
- said perforator 23 has a blunt and non-aggressive shape and forcibly perforates said lid.
- said perforator could comprise a pointed and / or cutting and / or tearing end, to favor the perforation of said ampule 1.
- said protective skirt 21 surrounding said cutting end any risk of injury would be avoided.
- the present invention thus makes it possible on the one hand to accurately take the hydro-alcoholic solution from the ampoule 1, after piercing the cap 10, by measuring the dosage to be administered, and on the other hand, to deliver said dosage in the gingivo-jugal gutter, for mucosal absorption instantaneous and complete of said dosage.
- This complete absorption typically lasts from 3 to 10 seconds, depending on the volume of solution administered.
- the connector 20 can be connected again to the bulb 1, thereby sealing the ampoule tightly and to prevent the evaporation of ethanol from the hydroalcoholic solution of this ampoule.
- the dosage remaining in the ampoule and if necessary to take it again for the same patient already treated previously if it appears necessary to take a new precise dose of the active ingredient and to administer it This allows for a certain time a saving of dosage, since the particular end of the syringe according to the invention serves as a stopper while remaining available to easily renew the administration of a dose.
- Figures 2 and 4 to 8 illustrate a second embodiment, wherein said syringe body 2 and said connector 20 are formed separately, said connector 20 having attachment means 26, 27 for attaching said connector 20 to said syringe body 2 .
- the connector 20 comprises a sleeve 22 incorporating said fixing means, which is extended by said outer protective skirt 21.
- said fixing means comprise screwing or detent means 26.
- these fastening means are final, that is to say after fixation, the connector can no longer be separated from the syringe body.
- FIGS 4 and 6 illustrate screwing means and Figures 5 and 7 illustrate snap-fastening means.
- said fixing means comprise locking means 27, such as a groove, which ensure a firm attachment of said connector 20 to said syringe body 2.
- locking means 27 such as a groove
- said removable connector could also be provided with a plug, for example formed by a suitable mobile accessory, to form a sealed plug device of the opening of the ampoule and thus to preserve the alcoholic quality of a possible evaporation.
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1550429A FR3031668A1 (fr) | 2015-01-20 | 2015-01-20 | Dispositif d'administration d'un principe actif par voie per-muqueuse buccale. |
PCT/FR2016/050097 WO2016116693A1 (fr) | 2015-01-20 | 2016-01-19 | Dispositif d'administration d'un principe actif par voie per-muqueuse buccale |
Publications (1)
Publication Number | Publication Date |
---|---|
EP3247424A1 true EP3247424A1 (de) | 2017-11-29 |
Family
ID=52737331
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP16705222.4A Withdrawn EP3247424A1 (de) | 2015-01-20 | 2016-01-19 | Vorrichtung zur verabreichung eines wirkstoffes über die orale mukosale route |
Country Status (4)
Country | Link |
---|---|
US (1) | US20180008515A1 (de) |
EP (1) | EP3247424A1 (de) |
FR (1) | FR3031668A1 (de) |
WO (1) | WO2016116693A1 (de) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10624817B2 (en) | 2015-03-24 | 2020-04-21 | Neomed, Inc. | Oral administration coupler for back-of-mouth delivery |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5009645A (en) * | 1989-06-12 | 1991-04-23 | Jules Silver | Syringe for dispensing measured quantities of a material |
GB9103291D0 (en) * | 1991-02-15 | 1991-04-03 | Waverley Pharma Ltd | Transfer adaptor |
US5921419A (en) * | 1998-05-04 | 1999-07-13 | Bracco Research Usa | Universal stopper |
GB9907014D0 (en) * | 1999-03-27 | 1999-05-19 | Smithkline Beecham Biolog | Novel device |
JP4427965B2 (ja) * | 2002-07-02 | 2010-03-10 | ニプロ株式会社 | 連通手段付き薬液容器 |
JP2005143677A (ja) * | 2003-11-13 | 2005-06-09 | Nipro Corp | 連通手段付き薬液容器 |
NZ548279A (en) * | 2003-12-18 | 2009-02-28 | Halkey Roberts Corp | Needleless access vial |
US7625210B2 (en) * | 2004-08-09 | 2009-12-01 | Ultradent Products, Inc. | Treatment devices for providing oral treatments and kits and methods that utilize such treatment devices |
FR2889506B1 (fr) | 2005-08-03 | 2010-08-27 | Flackpull | Ampoule operculee destinee a etre remplie d'un liquide par depression et procede de fabrication correspondant |
FR2906140B1 (fr) | 2006-09-22 | 2008-12-05 | Philippe Perovitch | Forme galenique pour l'administration par voie trans-muqueuse de principes actifs |
FR2910317B1 (fr) | 2006-12-21 | 2009-02-13 | Philippe Perovitch | Forme galenique pour l'administration par voie transmuqueuse de paracetamol |
BRPI0810542A2 (pt) * | 2007-04-23 | 2014-10-21 | Plastmed Ltd | Método para transferência sem contaminação de líquido, aparelho de transferência de fluídos, método de acoplamento do aparelho, seção conectora para uso em uma operação de transferência de fluídos e método de acoplamento da seção conectora |
FR2918874B1 (fr) | 2007-07-20 | 2009-10-09 | Philippe Perovitch | Dispositif de conditionnement et d'administration sub-linguale de principes actifs |
FR2926721B1 (fr) | 2008-01-30 | 2011-07-22 | Philippe Perovitch | Forme galenique pour l'adminsitration par voie trans-muqueuse de triptans |
FR2930140B1 (fr) | 2008-04-17 | 2011-04-22 | Philippe Perovitch | Dispositif pour la conservation, la preparation extemporanee et l'administration d'un faible dosage de principe actif |
FR2939321B1 (fr) | 2008-12-05 | 2011-08-26 | Philippe Perovitch | Dispositif de conditionnement et d'administration de principes actifs en solution hydro-alcoolique. |
FR2940120B1 (fr) | 2008-12-19 | 2012-07-13 | Philippe Perovitch | Formulation pour l'administration par voie trans-muqueuse de setrons |
FR2940116B1 (fr) | 2008-12-22 | 2012-07-06 | Philippe Perovitch | Formulation pour l'administration d'hypolipemiant par voie trans-muqueuse buccale |
FR2940911B1 (fr) | 2009-01-13 | 2012-09-21 | Philippe Perovitch | Formulation pour l'administration par voie trans-muqueuse buccale de molecules antalgiques et/ou anti-spasmodiques |
FR2947729B1 (fr) | 2009-07-10 | 2012-01-20 | Philippe Perovitch | Composition pharmaceutique pour le traitement du diabete de type ii par voie trans-muqueuse buccale |
FR2967894B1 (fr) | 2010-11-30 | 2013-11-29 | Philippe Perovitch | Dispositif de conditionnement, de conservation et de preparation extemporanee d'un ou plusieurs principe(s) actif(s). |
US20120279968A1 (en) * | 2011-05-05 | 2012-11-08 | The Andwin Corp. | Child Resistant Dosing Adapter Cap |
BR112013031764B1 (pt) * | 2011-06-10 | 2021-04-13 | Becton, Dickinson And Company | Fechamento para uso com um recipiente de coleta de amostra, recipiente de coleta de amostra e conjunto de transferência de fluido |
CA2861899C (en) * | 2012-01-17 | 2018-12-11 | Dr. Py Institute Llc | Multiple dose syringe and method |
FR3000896B1 (fr) | 2013-01-14 | 2016-08-26 | Philippe Perovitch | Forme galenique pour l'administration de principe(s) actif(s) permettant l'induction acceleree du sommeil et/ou le traitement des troubles du sommeil |
US20140257204A1 (en) * | 2013-03-05 | 2014-09-11 | Stuart Robert Lessin | Apparatus for reconstituting and dispensing drugs for topical application |
US9775950B2 (en) * | 2014-01-14 | 2017-10-03 | Parenteral Technologies, Llc | Syringe with dosage indicator for the visually impaired |
US20170354787A1 (en) * | 2016-06-10 | 2017-12-14 | Brell Medical Innovations, LLC | Safety syringe with dose window |
-
2015
- 2015-01-20 FR FR1550429A patent/FR3031668A1/fr active Pending
-
2016
- 2016-01-19 EP EP16705222.4A patent/EP3247424A1/de not_active Withdrawn
- 2016-01-19 US US15/544,762 patent/US20180008515A1/en not_active Abandoned
- 2016-01-19 WO PCT/FR2016/050097 patent/WO2016116693A1/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
US20180008515A1 (en) | 2018-01-11 |
FR3031668A1 (fr) | 2016-07-22 |
WO2016116693A1 (fr) | 2016-07-28 |
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