EP2180046A1 - Procédé de production d'acides gras à longues chaînes multi-insaturés dans des organismes transgéniques - Google Patents

Procédé de production d'acides gras à longues chaînes multi-insaturés dans des organismes transgéniques Download PDF

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Publication number
EP2180046A1
EP2180046A1 EP09179432A EP09179432A EP2180046A1 EP 2180046 A1 EP2180046 A1 EP 2180046A1 EP 09179432 A EP09179432 A EP 09179432A EP 09179432 A EP09179432 A EP 09179432A EP 2180046 A1 EP2180046 A1 EP 2180046A1
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EP
European Patent Office
Prior art keywords
seq
nucleic acid
acyl
fatty acids
fatty acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP09179432A
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German (de)
English (en)
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EP2180046B1 (fr
Inventor
Petra Cirpus
Amine Abbadi
Jelena Kirsch
Jörg BAUER
Ernst Heinz
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BASF Plant Science GmbH
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BASF Plant Science GmbH
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Publication date
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Publication of EP2180046A1 publication Critical patent/EP2180046A1/fr
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Publication of EP2180046B1 publication Critical patent/EP2180046B1/fr
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
EP09179432.1A 2004-12-23 2005-12-20 Procédé de production d'acides gras à longues chaînes multi-insaturés dans des organismes transgéniques Not-in-force EP2180046B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004062294A DE102004062294A1 (de) 2004-12-23 2004-12-23 Verfahren zur Herstellung von mehrfach ungesättigten langkettigen Fettsäuren in transgenen Organismen
EP05821795A EP1831358A2 (fr) 2004-12-23 2005-12-20 Procede de production d'acides gras a longues chaines multi-insatures dans des organismes transgeniques

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP05821795.1 Division 2005-12-20
EP05821795A Division EP1831358A2 (fr) 2004-12-23 2005-12-20 Procede de production d'acides gras a longues chaines multi-insatures dans des organismes transgeniques

Publications (2)

Publication Number Publication Date
EP2180046A1 true EP2180046A1 (fr) 2010-04-28
EP2180046B1 EP2180046B1 (fr) 2014-06-25

Family

ID=36590482

Family Applications (2)

Application Number Title Priority Date Filing Date
EP09179432.1A Not-in-force EP2180046B1 (fr) 2004-12-23 2005-12-20 Procédé de production d'acides gras à longues chaînes multi-insaturés dans des organismes transgéniques
EP05821795A Withdrawn EP1831358A2 (fr) 2004-12-23 2005-12-20 Procede de production d'acides gras a longues chaines multi-insatures dans des organismes transgeniques

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP05821795A Withdrawn EP1831358A2 (fr) 2004-12-23 2005-12-20 Procede de production d'acides gras a longues chaines multi-insatures dans des organismes transgeniques

Country Status (12)

Country Link
US (1) US7871804B2 (fr)
EP (2) EP2180046B1 (fr)
CN (1) CN101072869A (fr)
AU (1) AU2005321344A1 (fr)
BR (1) BRPI0519254A2 (fr)
CA (1) CA2591599A1 (fr)
DE (1) DE102004062294A1 (fr)
IL (1) IL183103A0 (fr)
MX (1) MX2007006535A (fr)
NO (1) NO20072663L (fr)
RU (1) RU2007127798A (fr)
WO (1) WO2006069936A2 (fr)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN108866181A (zh) * 2018-07-18 2018-11-23 北京泱深生物信息技术有限公司 Mboat1基因在子痫前期中的应用

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EP2357244A3 (fr) 2004-04-22 2011-11-23 Commonwealth Scientific and Industrial Research Organisation Synthèse d'acides gras polyinsaturés à longue chaîne par cellules recombinantes
ES2529572T3 (es) 2004-04-22 2015-02-23 Commonwealth Scientific And Industrial Research Organisation Síntesis de ácidos grasos poliinsaturados de cadena larga por células recombinantes
US7879591B2 (en) 2004-11-04 2011-02-01 E.I. Du Pont De Nemours And Company High eicosapentaenoic acid producing strains of Yarrowia lipolytica
CA2661697A1 (fr) * 2006-08-29 2008-03-06 Commonwealth Scientific And Industrial Research Organisation Synthese d'acides gras
AR074364A1 (es) 2008-11-18 2011-01-12 Commw Scient Ind Res Org Enzimas y metodo para producir acidos grasos omega -3
US9175318B2 (en) * 2008-12-18 2015-11-03 E. I. Dupont De Nemours And Company Reducing byproduction of malonates by yeast in a fermentation process
CA2758824A1 (fr) 2009-04-17 2010-10-21 Basf Plant Science Company Gmbh Promoteur vegetal apte a agir dans l'endosperme et ses utilisations
WO2010147907A1 (fr) 2009-06-16 2010-12-23 E. I. Du Pont De Nemours And Company Huiles à teneur élevée en acide éicosapentaénoïque à partir de souches optimisées améliorées de yarrowia lipolytica
US8524485B2 (en) 2009-06-16 2013-09-03 E I Du Pont De Nemours And Company Long chain omega-3 and omega-6 polyunsaturated fatty acid biosynthesis by expression of acyl-CoA lysophospholipid acyltransferases
EP2443248B1 (fr) 2009-06-16 2017-12-27 E. I. du Pont de Nemours and Company Amélioration de la biosynthèse d'acide gras oméga-3 et oméga-6 polyinsaturé à chaîne longue par l'expression d'acyl-coa lysophospholipide acyltransférase
EP2475679B1 (fr) 2009-06-16 2016-02-10 E. I. du Pont de Nemours and Company Souches optimisées améliorées de yarrowia lipolytica pour une production élevée d'acide éicosapentaénoïque
JP2013502914A (ja) 2009-08-31 2013-01-31 ビーエーエスエフ プラント サイエンス カンパニー ゲーエムベーハー 多価不飽和脂肪酸合成の増強を促進する植物の種子特異的遺伝子発現を増強する調節核酸分子
JP2013535987A (ja) 2010-08-26 2013-09-19 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 高レベルのエイコサペンタエン酸生産のための組換え微生物宿主細胞
US8790901B2 (en) 2011-12-14 2014-07-29 Pronutria, Inc. Microorganisms and methods for producing unsaturated fatty acids
DE102012200003B4 (de) 2012-01-02 2015-04-30 Ford Global Technologies, Llc Flüssigkeitsgekühlte Brennkraftmaschine und Verfahren zum Betreiben einer derartigen Brennkraftmaschine
US9096834B2 (en) 2012-02-24 2015-08-04 Exxonmobil Research And Engineering Company Recombinant microorganisms comprising thioesterase and lysophosphatidic acid acyltransferase genes for fatty acid production
US9181568B2 (en) * 2012-04-23 2015-11-10 Exxonmobil Research And Engineering Company Cell systems and methods for improving fatty acid synthesis by expression of dehydrogenases
SG11201408362SA (en) 2012-06-15 2015-01-29 Commw Scient Ind Res Org Production of long chain polyunsaturated fatty acids in plant cells
JP6351582B2 (ja) 2012-06-19 2018-07-04 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ アシルＣｏＡ：リゾホスファチジルコリンアシルトランスフェラーゼおよびリン脂質：ジアシルグリセロールアシルトランスフェラーゼの同時発現による多価不飽和脂肪酸の産生の改善
MX2015001780A (es) 2012-08-10 2015-09-28 Opx Biotechnologies Inc Microorganismos y métodos para la producción de ácidos grasos y productos derivados de ácidos grasos.
EP2935601B1 (fr) * 2012-12-21 2018-03-21 E. I. du Pont de Nemours and Company Cellules microbiennes recombinantes qui produisent au moins 28 % d'acide eicosapentaénoïque en poids de cellules sèches
US9447438B2 (en) 2013-03-15 2016-09-20 Cargill, Incorporated Acetyl-coA carboxylases
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
US10337038B2 (en) 2013-07-19 2019-07-02 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
CN111154724B (zh) 2013-12-18 2024-02-06 联邦科学技术研究组织 包含二十二碳六烯酸的提取的植物脂质
SG11201610596PA (en) 2014-06-27 2017-01-27 Commw Scient Ind Res Org Lipid comprising docosapentaenoic acid
EP2993228B1 (fr) 2014-09-02 2019-10-09 Cargill, Incorporated Production d'esters d'acides gras
US11345938B2 (en) 2017-02-02 2022-05-31 Cargill, Incorporated Genetically modified cells that produce C6-C10 fatty acid derivatives
US11603549B2 (en) 2017-09-12 2023-03-14 Bio Capital Holdings, LLC Biological devices and methods of use thereof to produce carotenoids
CN113502295B (zh) * 2021-06-09 2022-06-07 西北农林科技大学 TmLPCAT基因用于提高三酰甘油sn-2位超长链脂肪酸含量的应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000018889A2 (fr) * 1998-09-25 2000-04-06 Calgene Llc Nouvelles acyltransferases vegetales
FR2785911A1 (fr) * 1998-11-18 2000-05-19 Agronomique Inst Nat Rech Gene codant pour une acyltransferase de colza, et ses utilisations
US20040034888A1 (en) * 1999-05-06 2004-02-19 Jingdong Liu Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
WO2004076617A2 (fr) 2003-02-27 2004-09-10 Basf Plant Science Gmbh Procede de production d'acides gras polyinsatures
WO2004087902A2 (fr) * 2003-03-31 2004-10-14 University Of Bristol Nouvelles acyltransferases vegetales specifiques pour acides gras a longue chaine polyinsatures

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000018889A2 (fr) * 1998-09-25 2000-04-06 Calgene Llc Nouvelles acyltransferases vegetales
FR2785911A1 (fr) * 1998-11-18 2000-05-19 Agronomique Inst Nat Rech Gene codant pour une acyltransferase de colza, et ses utilisations
US20040034888A1 (en) * 1999-05-06 2004-02-19 Jingdong Liu Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
WO2004076617A2 (fr) 2003-02-27 2004-09-10 Basf Plant Science Gmbh Procede de production d'acides gras polyinsatures
WO2004087902A2 (fr) * 2003-03-31 2004-10-14 University Of Bristol Nouvelles acyltransferases vegetales specifiques pour acides gras a longue chaine polyinsatures

Non-Patent Citations (5)

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Title
DAHLQVIST A ET AL: "Phospholipid:diacylglycerol acyltransferase: an enzyme that catalyses the acyl-coA-independent formation of triacylglycerol in yeast and plants", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 97, no. 12, 6 June 2000 (2000-06-06), pages 6487 - 6492, XP002235601, ISSN: 0027-8424 *
DATABASE UniProt [online] 6 December 2005 (2005-12-06), "Lysophosphatidic acid acyltransferase, putative.", XP002387919, retrieved from EBI Database accession no. Q337H3 *
DOMERGUE F ET AL: "Relief for fish stocks: oceanic fatty acids in transgenic oilseeds", TRENDS IN PLANT SCIENCE, ELSEVIER SCIENCE, OXFORD, GB, vol. 10, no. 3, March 2005 (2005-03-01), pages 112 - 116, XP004776171, ISSN: 1360-1385 *
YAMASHITA A ET AL: "ATP-independent fatty acyl-coenzyme A synthesis from phospholipid: coenzyme A-dependent transacylation activity toward lysophosphatidic acid catalyzed by acyl-coenzyme A:lysophosphatidic acid acyltransferase.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. 20 JUL 2001, vol. 276, no. 29, 20 July 2001 (2001-07-20), pages 26745 - 26752, XP002387917, ISSN: 0021-9258 *
YAMASHITA ATSUSHI ET AL: "Acyltransferases and transacylases involved in fatty acid remodeling of phospholipids and metabolism of bioactive lipids in mammalian cells", JOURNAL OF BIOCHEMISTRY (TOKYO), vol. 122, no. 1, 1997, pages 1 - 16, XP002387916, ISSN: 0021-924X *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108866181A (zh) * 2018-07-18 2018-11-23 北京泱深生物信息技术有限公司 Mboat1基因在子痫前期中的应用
CN108866181B (zh) * 2018-07-18 2020-06-30 青岛泱深生物医药有限公司 Mboat1基因在子痫前期中的应用

Also Published As

Publication number Publication date
CA2591599A1 (fr) 2006-07-06
CN101072869A (zh) 2007-11-14
WO2006069936A3 (fr) 2007-03-22
US7871804B2 (en) 2011-01-18
RU2007127798A (ru) 2009-01-27
US20090094707A1 (en) 2009-04-09
IL183103A0 (en) 2007-09-20
AU2005321344A1 (en) 2006-07-06
NO20072663L (no) 2007-09-06
MX2007006535A (es) 2007-07-25
BRPI0519254A2 (pt) 2009-01-06
DE102004062294A1 (de) 2006-07-06
WO2006069936A2 (fr) 2006-07-06
EP2180046B1 (fr) 2014-06-25
EP1831358A2 (fr) 2007-09-12

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