EP2167021A1 - Composition de dentifrice - Google Patents

Composition de dentifrice

Info

Publication number
EP2167021A1
EP2167021A1 EP08774508A EP08774508A EP2167021A1 EP 2167021 A1 EP2167021 A1 EP 2167021A1 EP 08774508 A EP08774508 A EP 08774508A EP 08774508 A EP08774508 A EP 08774508A EP 2167021 A1 EP2167021 A1 EP 2167021A1
Authority
EP
European Patent Office
Prior art keywords
weight
composition
zinc
dentifrice
dentifrice composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08774508A
Other languages
German (de)
English (en)
Inventor
Rupesh Kumar Agarwal
Edward Francis
Alison Katharine Green
Rekha Navada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unilever PLC
Unilever NV
Original Assignee
Unilever PLC
Unilever NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever PLC, Unilever NV filed Critical Unilever PLC
Priority to EP08774508A priority Critical patent/EP2167021A1/fr
Publication of EP2167021A1 publication Critical patent/EP2167021A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to dentifrices, particularly to toothpastes and more particularly to toothpastes that contain zinc salts, while exhibiting lower astringency.
  • EP0162574 (1985, Johnson & Johnson) describes the reduction of astringency by the use of pluronic type of polymers, i.e. polyethylene oxide - polypropylene oxide block copolymers as surfactants. The present inventors have found that while this provides for reduction of astringency, it remains a costly option. Similarly, EP0251542 (1988, Lion Corporation) describes reduction of astringency of zinc salts by the use of polyoxyethylene-hydrogenated castor oil.
  • the present inventors have found that the astringent aftereffect associated with dentifrice compositions containing zinc salts can be reduced to a significant extent by the use of a polyethylene oxide and a humectant.
  • compositions exhibited significant reduction in astringency
  • compositions also offered protection against oral malodour for a significantly longer period of time upon continued usage.
  • a dentifrice composition that includes: (i) 0.1 to 5 % by weight zinc salt; (ii) 0.01 to 1.0 % by weight polyethylene oxide having molecular weight of from 100,000 to 8,000,000 g/mol; and
  • it includes 0.1 to 2 % by weight zinc salt.
  • the composition includes 0.1 to 0.5 % by weight polyethylene oxide of molecular weight from 100,000 to 8,000,000 g/mol.
  • the high molecular weight polyethylene oxide for use according to the invention should be understood to mean polyethylene oxide of molecular weight from 100,000 to 8,000,000 g/mol.
  • the zinc salt is selected from zinc chloride, zinc sulphate or zinc citrate, more preferably it is zinc sulphate .
  • a process for making a dentifrice composition that includes mixing 0.1 to 5 parts by weight zinc salt with 0.01 to 1 parts by weight polyethylene oxide having molecular weight of from 100,000 to 8,000,000 g/mol and 10 to 70 parts by weight humectant, with a suitable vehicle.
  • dentifrice means a substance for cleaning the teeth which is suitable for application with a toothbrush and is rinsed off after use. It can be a paste, gel, or liquid formulation. Dentifrice compositions herein can be single, dual or multi phase preparations such as deep striped, surface striped, multilayered, core in sheath, for example having gel surrounding paste, or any combination thereof .
  • a single phase may include a liquid carrier with one or more insoluble particles, such as of a dental abrasive, homogeneously dispersed within it.
  • the dentifrice composition comprises more than one phase
  • said phases may be contained in physically separated compartments of a dispenser and dispensed side-by-side or they may contained in packaging in which they are in direct contact .
  • An essential component of the dentifrice compositions according to the invention is a zinc salt.
  • Zinc salts are effective as antimicrobial agents.
  • the zinc salt preferably has a solubility of at least 0. Ig per lOOg water but insoluble materials such as zinc oxide can provide soluble zinc salts if used in conjunction with other solubilizing materials, such sodium citrate.
  • Zinc salts useful in the present invention include zinc chloride, zinc sulphate, zinc nitrate, zinc citrate, zinc gluconate, zinc acetate, zinc lactate and zinc salicylate. Mixed salts such as sodium zinc citrate can also be used.
  • Preferred zinc salts are zinc salts of organic acids such as zinc citrate, zinc lactate, zinc maleate, zinc salicylate, zinc gluconate and zinc ascorbate.
  • the most preferred salt is Zinc sulphate. Mixtures of different zinc salts can be used.
  • the zinc salt is preferably incorporated in the oral care composition of the present invention at a concentration of about 0.1 to 5 % by weight and preferably about 0.1 to about 2% by weight and most preferably, the zinc salt level is from 0.1 to 0.5% by weight. Excess amounts of zinc will lead to unacceptable taste and higher level of astringency and may cause problems of compatibility with other ingredients such as e.g., precipitation of anionic polymers.
  • the polyethylene oxide having molecular weight of from 100,000 to 8,000,000 g/mol used in the present invention affords a slippery feel to the oral cavity and thereby re- lubricates the mouth.
  • the molecular weight is from 600,000 to 2,000,000 g/mol, and more preferably from 800,000 to 1,000,000 g/mol.
  • POLYOX ® is the trade name for a high molecular weight polyethylene oxide produced by Dow Chemicals. A particularly preferred material is available from Dow Chemicals as POLYOX ® WSR 301-NF.
  • Useful levels of the high molecular weight polyethylene oxide for use according to the invention are from about 0.01% to about 1%, preferably from about 0.1% to about 0.5 % and most preferably 0.1 % to 0.2 % by weight of the composition. Additional level of such polyethylene oxide was observed to present problems with its dispersion in the medium.
  • the dentifrice composition according to the invention includes a humectant which enhances flavour, prevents harsh taste and provides a fresh and pleasant sensation in the mouth. It also prevents caking of the dentifrice.
  • the humectant serves to keep the dentifrice compositions from hardening upon exposure to air and may also impart a desirable sweetness to the formulations to further minimize the astringency ascribed to the zinc salt.
  • Humectant is preferably present in a total amount of about 10-70%, more preferably about 25-60% by weight.
  • Typical humectants include sorbitol (typically added as 70% aqueous solution) , glycerine, maltitol and xylitol.
  • the dentifrice contains about 16-30% glycerine in an opaque cream base, while a combination of 10 to 30 wt% glycerine and 30 to 50 wt% sorbitol (as 70% aqueous solution) is used for clear gel compositions.
  • a gel composition comprising 20 wt% glycerine and 40 wt% sorbitol (as 70% aqueous solution) would comprise humectant in a total amount of 48 wt% (20+ [40x0.70 ] ) , assuming no other humectants present.
  • Sorbitol solution supplies sweetness and body to the composition and gives a desirable mouth feel. It is preferred that a mixture of glycerine and sorbitol is used for a lubricated mouth feel.
  • an effective amount of sweetener is utilized to provide the level of sweetness desired. This amount will vary with the sweetener selected and the composition.
  • the amount of sweetener normally present is from about 0.0025 % by weight to about 60 % by weight of the dentifrice composition .
  • water is generally not present at more than 10%, typically about 2-5% by weight.
  • water employed in the preparation of commercially suitable dentifrices should preferably be deionised and free of impurities. Water comprises from about 0.05 to 70.0%, preferably from about 15.0 to 50.0% by weight of the formulations. These amounts of water include the free water which is added and also that which is introduced with other materials, such as 70% aqueous sorbitol solution.
  • the liquid phase of the composition of the present invention is preferably formulated such that its refractive index closely matches the refractive index of the silicas which are also present in the composition.
  • the liquid phase usually comprises water and a humectant, the latter usually being sorbitol or glycerol.
  • Water has an RI (refractive index) of 1.333; sorbitol (70% aqueous solution) has an RI of 1.457 and glycerine has an RI of 1.473.
  • the refractive index of the liquid phase can be calculated from the respective refractive indices of the constituting ingredients.
  • compositions of the invention may contain further optional ingredients, as long as the clarity of the dentifrices, when in gel form, is thereby not impaired and the RI of the liquid phase is about the RI of the low refractive index abrasive silica.
  • Another preferred ingredient is a water-soluble fluoride compound, used in an amount sufficient to give a fluoride concentration in the composition of from about 0.0025% to about 0.5% by weight, to provide anti-caries effectiveness.
  • fluoride ion-yielding materials can be employed as sources of soluble fluoride in the present compositions.
  • Representative fluoride ion sources include stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate and many others. Stannous fluoride and sodium fluoride are particularly preferred, as well as mixtures thereof.
  • sodium fluoride is used in combination with the long chain polyphosphates then it is preferably kept in a separate phase.
  • the dentifrices of the invention may also contain coloured particles suspended therein, e.g. coloured silica agglomerates or other coloured particles to impart a "speckled" appearance to the dentifrices.
  • the colouring agent may be in the form of an aqueous solution, preferably 1% colouring agent in a solution of water. Colour solutions generally comprise from 0.01% to 5% by weight of the composition .
  • Titanium dioxide may also be added to the present composition. Titanium dioxide is a white powder which adds opacity to the compositions. Titanium dioxide may comprise from 0.25% to 5%, by weight of the composition.
  • further gelling or binding agent such as organic thickeners of natural and synthetic gums may be incorporated in the compositions of the present invention.
  • organic thickeners are carrageenan (Irish moss), xanthan gum, sodium carboxymethyl cellulose, starch, polyvinylpyrrolidone, hydroxyethylpropylcellulose, hydroxybutyl methyl cellulose, hydroxypropyl methyl cellulose, and hydroxyethyl cellulose.
  • compositions according to the invention may also include polyethylene oxide of molecular weight less than 100,000.
  • Such materials for example polyethylene glycol 1500, are often included to improve the cohesion of the composition.
  • the organic thickener may be incorporated in the compositions of the present invention at a concentration of 10 about 0.25 to about 2% by weight and preferably about 0.5 to about 1% by weight of the composition.
  • Synthetic finely divided pyrogenic silica such as those sold under the trademarks CAB-O-SIL ® M-5, SYLOID ® 244, SYLOID ® 266 and AEROSIL ® D-200 may also be employed in amounts of about 1-5% by weight to promote thickening or gelling of the dentifrice .
  • Antibacterial agents commonly known in the art may also be employed in the dentifrice compositions of the instant invention to provide a total content of such agents of up to about 5% by weight.
  • flavouring or sweetening materials include the flavouring oils, e.g. oils of spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon, lemon and orange as well as methylsalicylate, oil of wintergreen, oil of peppermint, oil of spearmint, clove bud oil, menthol, anethole, methyl salicylate, eucalyptol, cassia, 1-menthyl acetate, sage, eugenol, parsley oil, oxanone, alpha-irisone, marjoram, lemon, orange, propenyl guaethol, cinnamon, vanillin, ethyl vanillin, heliotropine, 4-cis-heptenal, diacetyl, methyl-para-tert-butyl phenyl acetate,
  • a flavour system is generally used in the compositions at levels of from 0.001% to 5%, by weight of the composition. Addition of the flavour takes care of the metallic aftertaste of Zinc salts.
  • the composition further preferably includes a coolant.
  • coolants in the present compositions are the paramenthane carboxyamide agents such as N-ethyl-p-menthan- 3-carboxamide, (known commercially as “WS-3”) and mixtures thereof and menthone glycerine acetal (known commercially as "MGA”) .
  • Suitable sweetening agents include sucrose, lactose, maltose, sorbitol, sodium cyclamate, perillartine, and saccharine.
  • the present invention may also include xylitol.
  • Xylitol is a sugar alcohol that is used as a sweetener and humectant. Xylitol may provide a therapeutic effect, such as an antibacterial or anticaries effect.
  • compositions typically comprise xylitol at a level from 0.01% to 25%, preferably from 3% to 15%, more preferably from 5% to 12%, and most preferably from 9% to 11% by weight of the total composition.
  • xylitol is used as a sweetener, it may be present at a lower level, such as from 0.005% to 5%, by weight of the dentifrice composition.
  • Surfactant levels cited herein are on a 100% active basis, even though common raw materials such as sodium lauryl sulphate may be supplied as aqueous solutions of lower activity.
  • the surfactant is important for oral cleaning, both thorough removal of dirt from surfaces and in foam generation to suspend removed dirt.
  • Suitable surfactant levels are from about 2% to about 15%, preferably from about 2.2% to about 10%, more preferably from about 2.5 to about 5% by weight of the total composition.
  • Suitable surfactants for use herein include anionic, amphoteric, non-ionic, zwitterionic and cationic surfactants, though anionic, amphoteric, non-ionic and zwitterionic surfactants (and mixtures thereof) are preferred.
  • Abrasives is normally included in the composition.
  • Abrasives may be selected from water-insoluble alkali or alkaline earth metal salts of metaphosphate, calcium carbonate, aluminate and silicate. Especially preferred are silica, dicalcium phosphate and calcium carbonate. Amount of the abrasive range from about 5 to about 80% by weight of the composition. Also suitable are chalk-type abrasives such as calcium and magnesium carbonates, silicas including xerogels, hydrogels, aerogels and precipitates, alumina and hydrates thereof.
  • Abrasives include alpha alumina trihydrate, aluminosilicates such as calcined aluminium silicate and aluminium silicate, magnesium and zirconium silicates such as magnesium trisilicate and thermosetting polymerised resins such as particulate condensation products of urea and formaldehyde, polymethylmethacrylate, powdered polyethylene. Mixtures of abrasives can also be used.
  • the abrasive polishing materials generally have an average particle size of from about 0.1 to about 30 microns, preferably from about 5 to 15 microns.
  • Silica dental abrasives of various types offer exceptional dental cleaning and polishing performance without unduly abrading tooth enamel or dentin.
  • the silica abrasive can be precipitated silica or silica gels for example silica xerogels marketed under the trade name SYLOID ® by W. R. Grace & Company, Davison Chemical Division.
  • Suitable precipitated silica materials include those marketed by the J. M. Huber Corporation under the trade name, ZEODENT ® 119 or ZEODENT ® 118.
  • Suitable abrasive levels are from about 1% to about 40%, preferably at least about 2%, such as from about 2% to about 20%, more preferably at least about 5%, such as from about 5% to about 15% by weight of the composition.
  • Tartar control agents may be incorporated into compositions of this invention, especially effective are agents containing phosphorous.
  • Inorganic phosphorous tartar control agents may include any of the water-soluble pyrophosphates such as disodium pyrophosphate, dipotassium pyrophosphate and mixtures of these with tetrapotassium pyrophosphates or tetrasodium pyrophosphates.
  • Organic phosphorous compounds that may serve as tartar control agents include polyphosphonates such as disodium ethane-l-hydroxy-1, 1-diphosphonate (EHDP) and methanediphosphonic acid.
  • polyphosphonates such as disodium ethane-l-hydroxy-1, 1-diphosphonate (EHDP) and methanediphosphonic acid.
  • compositions according to the invention have a pH in the range of 5 to 8, preferably 6.5 to 7.5, e.g. 7.
  • the present invention also relates to a process for making a dentifrice composition that includes mixing 0.1 to 5 parts by weight zinc salt with 0.01 to 1 parts by weight polyethylene oxide having molecular weight of from 100,000 to 8,000,000 g/mol and 10 to 70 parts by weight humectant, with a suitable vehicle.
  • humectants such as glycerine and sorbitol
  • the high molecular polyethylene oxide for use according to the invention for use according to the invention
  • zinc salt to water and mix for 10 to 15 minutes in a conventional mixer.
  • optional ingredients e.g. silica and carboxymethylcellulose
  • surfactants e.g. sodium silica and sodium bicarbonate
  • the mix may then be de-aerated under vacuum.
  • Flavour and colour ingredients may then be added and mixing continued for a further 10-15 minutes and further de- aeratation under vacuum.
  • the resultant product is typically a stable dentifrice of texture like that of normal gels and of satisfactory flavour.
  • composition -1 A core and sheath type of toothpaste was made with the core and the sheath being a gel.
  • the ingredients of the composition (Composition -1) have been listed in table-1.
  • organoleptic judges participated in scoring the volunteers. These judges were also asked to refrain from drinking hot beverages, smoking, consuming alcohol or using cosmetics during the study. Each volunteer was asked to close the mouth for 60 seconds and not swallow during this period. After one minute the volunteer breathed out the mouth air gently through a diameter of 24mm / length 5 cm tube at a distance of approximately 10 cm from the nose of the odour judge who were hidden behind the screen and would immediately record the odour on a 0-5 organoleptic scale.
  • the organoleptic scale of 0 to 5 was as follows: 0 No odour present
  • Odour is of low intensity and within organoleptically acceptable limits.
  • Composition-1 offers a significant reduction in oral malodour level on day-1 itself, even after two hours of brushing.
  • composition-1 offers significant reduction in malodour level even before brushing (i.e. after 12 hours from the last brushing, overnight) on 4 weeks of continued use (twice daily) and the difference between the placebo score and that of composition-1 after 2 hours of brushing in this case is very significant. This therefore, goes to - I i
  • composition is capable of offering protection against oral malodour for a significantly longer period of time upon continued usage.
  • VSC Volatile Sulphur Content
  • Oral malodour measurements were made on each volunteer using the Halimeter. On the morning of each test, the volunteers did not consume any food/confectionery or use any mouthwash prior to their baseline assessment. Volunteers abstained from eating and drinking for the duration of each visit. After the baseline assessment, volunteers were made to brush one full brush length with the appropriate dentifrice for 2 minutes. Oral malodour measurements were made using the InterScan Halimeter Model RH-17K (standard Operating Procedure) at 12 hours before brushing, 10 minutes after brushing and 2 hours post brushing.
  • composition-1 is Composition-1
  • compositions containing 0.2, 0.4 and 0.7% zinc sulphate were made in which the formulations were identical to that in Table-1, except for the increased/decreased levels of zinc Sulphate, with a corresponding increase/decrease in the content of water in the corresponding formulations.
  • Efficacy of the dentifrices was evaluated by studying BDCOH (4 , 4 ' -bis (dimethylamino) diphenylcarbinol) levels in saliva, pre and post brushing. This is also an indicator of the level of malodour.
  • compositions according to the invention also provide other desirable consumer benefits.
  • composition Comparative Example 1
  • Comparative Example 1 The following composition, Comparative Example 1, was prepared and was used by 200 volunteers for a period of 1 week, twice daily. Thereafter, they rated the composition for various consumer desirable benefits, as being on parity or better than the composition according to the invention as in table-1.
  • composition 1 in accordance with the invention is able to meet most of the desirable consumer attributes, when compared to a formulation devoid of high molecular weight polyethylene oxide in accordance.
  • Composition-1 and Comparative Example-1 were also compared by 15 expert panel members.
  • the aim of this study was to evaluate and compare the mouth feel, foam levels, flavour intensity and flavour related attributes.
  • Panellists brushed their teeth with one full brush length for 60 seconds. They assessed the various attributes using the line scale from 0 to 10, zero being the lowest and 10 being the highest score. Average results of their comparative assessment have been compiled in the following table-8.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

L'invention porte sur une composition de dentifrice qui comprend : iv) 0,1 à 5 % en poids de sel de zinc; v) 0,01 à 1,0 % en poids de poly(oxyde d'éthylène) ayant une masse moléculaire de 100000 à 8000000 g/mol; et vi) 10 à 70 % en poids d'un humectant.
EP08774508A 2007-07-16 2008-06-30 Composition de dentifrice Withdrawn EP2167021A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08774508A EP2167021A1 (fr) 2007-07-16 2008-06-30 Composition de dentifrice

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN1356MU2007 2007-07-16
EP07119468 2007-10-29
EP08774508A EP2167021A1 (fr) 2007-07-16 2008-06-30 Composition de dentifrice
PCT/EP2008/058354 WO2009010381A1 (fr) 2007-07-16 2008-06-30 Composition de dentifrice

Publications (1)

Publication Number Publication Date
EP2167021A1 true EP2167021A1 (fr) 2010-03-31

Family

ID=39651426

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08774508A Withdrawn EP2167021A1 (fr) 2007-07-16 2008-06-30 Composition de dentifrice

Country Status (3)

Country Link
EP (1) EP2167021A1 (fr)
CN (1) CN101801336A (fr)
WO (1) WO2009010381A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE487441T1 (de) 2007-06-01 2010-11-15 Allergan Inc Gerät zur erzeugung des zugspannungsinduzierten wachstums von biologischem gewebe
WO2018166673A1 (fr) * 2017-03-13 2018-09-20 Unilever Plc Compositions de soins buccodentaires

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3888976A (en) * 1972-09-21 1975-06-10 William P Mlkvy Zinc and strontium ion containing effervescent mouthwash tablet
US4416867A (en) * 1979-06-20 1983-11-22 Lever Brothers Company Oral compositions
JPH0747531B2 (ja) * 1986-06-27 1995-05-24 ライオン株式会社 口腔用組成物
NZ232572A (en) * 1989-03-13 1991-11-26 Vipont Pharma Oral rinse composition containing a benzophenanthridine alkaloid extract from sanguinaria canadesis
US5302373A (en) * 1993-06-10 1994-04-12 Church & Dwight Co., Inc. Liquid mouthwash containing a particulate bicarbonate suspension
US5820854A (en) * 1997-03-27 1998-10-13 The Procter & Gamble Company Oral compositions containing polyoxyethylene
US5820853A (en) * 1997-03-27 1998-10-13 The Procter & Gamble Company Oral compositions forming a coacervate gel

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2009010381A1 *

Also Published As

Publication number Publication date
CN101801336A (zh) 2010-08-11
WO2009010381A1 (fr) 2009-01-22

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