EP2118624A1 - Dispositif de dosage pour un système de perfusion - Google Patents
Dispositif de dosage pour un système de perfusionInfo
- Publication number
- EP2118624A1 EP2118624A1 EP08716055A EP08716055A EP2118624A1 EP 2118624 A1 EP2118624 A1 EP 2118624A1 EP 08716055 A EP08716055 A EP 08716055A EP 08716055 A EP08716055 A EP 08716055A EP 2118624 A1 EP2118624 A1 EP 2118624A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- substance
- volume
- dosing
- opening
- cylinder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14212—Pumping with an aspiration and an expulsion action
- A61M5/14216—Reciprocating piston type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/22—Valves or arrangement of valves
- A61M39/24—Check- or non-return valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
- A61M5/152—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags pressurised by contraction of elastic reservoirs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16804—Flow controllers
- A61M5/16809—Flow controllers by repeated filling and emptying of an intermediate volume
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
- A61M5/1684—Monitoring, detecting, signalling or eliminating infusion flow anomalies by detecting the amount of infusate remaining, e.g. signalling end of infusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
- A61M5/16854—Monitoring, detecting, signalling or eliminating infusion flow anomalies by monitoring line pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
- A61M5/16854—Monitoring, detecting, signalling or eliminating infusion flow anomalies by monitoring line pressure
- A61M5/16859—Evaluation of pressure response, e.g. to an applied pulse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16877—Adjusting flow; Devices for setting a flow rate
- A61M5/16881—Regulating valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31525—Dosing
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B53/00—Component parts, details or accessories not provided for in, or of interest apart from, groups F04B1/00 - F04B23/00 or F04B39/00 - F04B47/00
- F04B53/16—Casings; Cylinders; Cylinder liners or heads; Fluid connections
- F04B53/162—Adaptations of cylinders
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
- G01F11/02—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
- G01F11/04—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the free-piston type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
- A61M2005/16863—Occlusion detection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/15—Detection of leaks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
- A61M2205/7536—General characteristics of the apparatus with filters allowing gas passage, but preventing liquid passage, e.g. liquophobic, hydrophobic, water-repellent membranes
Definitions
- the present invention relates to a metering and conveying device and more particularly to a device for metering a substance to be delivered to a patient, for example by means of an infusion set.
- an implantable device for the metered delivery of pharmaceutical fluids in the human or animal body wherein the implantable unit a cam-controlled, valveless axial piston pump with a rotatably driven and axially displaceable piston, connected to the suction side of the pump liquid reservoir and a having controllable, connected to the piston rotary drive.
- a suction opening and a pressure opening is arranged at a lower end of a cylinder, wherein the two openings are diametrically opposed and extend coaxially.
- US 6,010,485 discloses a power cylinder having a similar construction as in CH 688 224 A5.
- US 6,749,587 B2 discloses a modular infusion device with a measuring section which can directly control the fluid flow between a reservoir and a cannula.
- the metering section may include a peristaltic mechanism, a positive displacement pump or other pumping device.
- a device for administering insulin to a patient wherein in a pumping chamber, a piston is arranged, a cannula is connected to the pumping chamber and a piston rod is connected to the piston.
- the piston When the piston is withdrawn, the reservoir is connected to the pumping chamber to fill up the pumping chamber and when the piston is moved forwards, by means of a Valve closed the passage from the reservoir to the pumping chamber, so that the substance can be administered via a cannula.
- a fluid measuring element for an implantable delivery system is known, which is coupled between a pressurized fluid source and an outlet port to provide discrete flow pulses at a predetermined rate.
- US 2004/0069044 A1 discloses a device for measuring a volume of a drug.
- the apparatus includes a first chamber containing the liquid drug, a measuring chamber in fluid communication with the first chamber, and a measuring assembly.
- US 5,207,666 discloses a fluid meter for implantable drug delivery systems that can be placed between a pressurized fluid source and an outlet port to provide discrete flow implants at a predetermined rate.
- EP 1 633 417 B1 discloses a delivery device with a storage chamber and an infection chamber, which are coupled via a fluid connection and in each of which plungers are arranged.
- a dosing device for an infusion system has a variable volume dosing unit, such as a cylinder with a piston moving in the cylinder and volume increasing or decreasing volume.
- the metering device has a supply and a discharge port, which is preferably formed by a single port, such as a single port, eg on the cylinder or on a port part or on a sleeve, and is otherwise preferably closed.
- the variable volume of the dosing unit can be filled with the substance to be dispensed, for example from a storage container, such as an ampoule, as the volume of the dosing unit increases.
- the metering device is designed so that the supply and discharge port, so for example the only opening of the metering unit, preferably alternately with a reservoir, such as an ampoule, and a dispensing or administering unit, such as an infusion set, can be connected.
- a reservoir such as an ampoule
- a dispensing or administering unit such as an infusion set
- leakage or inadvertent and uncontrolled passage of a substance from a reservoir to a delivery unit, such as an infusion set, can be prevented because the metering unit is coupled either to the reservoir only or to the delivery device only.
- the reservoir is thus completely decoupled from the administration unit, so the reservoir is advantageously never connected directly to the output.
- the supply and discharge port can also be formed by a plurality of openings, which should then always be connected to an external terminal, that the metering unit is either only filled or only emptied through all or part of the openings, ie a simultaneous recording or dispensing one Substance is not possible.
- the one or more inlet-outlet connections or ports or holes of the dosing unit are coupled so that they can either be coupled to a reservoir and thus act as an inlet to the dosing unit, or with an administering device such as an infusion device , can be coupled, and so act as an outlet for the metering unit.
- the connections of the dosing unit are preferably closed when no substance is taken up or dispensed. It is also possible to actively close the openings, for example by a displaceable sealing element, in a rest position between a dispensing or receiving a substance.
- the dosing unit can be displaceable or rotatable in order to be connected to one of two or more external connections for filling the dosing unit and for dispensing and forwarding the substance dispensed by the dosing unit, depending on the displacement position or rotational position.
- one or more of the external terminals can be slidably or rotatably provided on the dosing unit, so that the displaceable connections are connected, for example, alternately to the supply and discharge opening of the dosing unit.
- a valve action can be obtained by a kind of switching valve.
- a motor is provided, with which the dosing unit or the supply and discharge connection of the dosing unit moves and can be rotated or moved, for example, the motor alternatively or additionally also for movement, ie for example
- the external supply and discharge ports can be used to connect them alternately with the supply and discharge port of the metering unit.
- the or another motor can be used to increase or decrease the volume, for example, to move the piston.
- Piston of the cylinder designed so that it can be moved exactly to a predetermined position within the cylinder, so for example exactly to a predefined maximum extension position of the piston, which is still advantageous within the
- Cylinder is located. Thus, unlike known so-called “single-stroke” methods, only a portion of the variable (cylinder) volume can be used for dosing.
- connection points or connection lines which lead to the supply or discharge connection of the dosing unit advantageously each have at least one valve, whereby only a single valve can be provided either in the supply or in the delivery line or in the supply and discharge connection.
- a valve can ensure in one or both of the lines, for example as a check valve, that a substance to be dispensed in a metered manner is conveyed only in one direction, whereby the return flow of the substance in the opposite direction is prevented or prevented.
- the one or more valves used on or in the feed and discharge lines and / or on or in the metering unit may be check valves, which allow a flow of a substance or a liquid in one direction only or may also be designed as pressure relief valves, which is a passage of a Material or a liquid only after applying a minimum pressure allow.
- the storage container which contains the metered after passage through the metering substance to be dispensed substance may be pressurized or depressurized.
- the reservoir may be an ampoule in which a pressurized plug acts on the substance to be dispensed, so that the substance to be dispensed only needs to be dispensed and no further energy for the actual substance delivery from the ampoule or the dosing or transfer into the microdosing required becomes.
- the pressurization of the plug can be done for example by means of a spring or a pressurized gas.
- the reservoir may have an elastic region or be formed entirely of an elastic material, such as a bag, which is filled with the substance to be dispensed.
- a force or a pressure can act on the elastic region or pouch by means of a spring in order to displace and dispense the substance contained in the reservoir, if this is made possible by the dosing device connected downstream of the reservoir.
- a reservoir or reservoir is designed or constructed such that positive pressure is applied to an exit or discharge opening of the reservoir, such as by pressurized containers or bags, or by an active drive mechanism acting on a displacement element of the reservoir or the reservoir itself acts, can be achieved.
- the dosing device has at least one sensor for checking the functionality or detecting a malfunction, such as a leak sensor, galvanic or Leitwertsensor, a bubble sensor, a pressure sensor or a force sensor, which can determine, for example, whether a substance or liquid has leaked out of the metering device, whether, for example, bubbles are contained in the substance to be dispensed, or if, for example, there is an occlusion.
- a leak sensor galvanic or Leitwertsensor
- a bubble sensor e.g., a bubble sensor
- a pressure sensor or a force sensor e.g., a pressure sensor or a force sensor
- This at least one sensor can be equipped with a warning or alarm display or a control of Metering device may be connected to turn off the metering device, for example, if a malfunction is detected or to issue in the case of a detected malfunction of the metering device, for example, an optical or audible alarm signal.
- a gas or air-permeable material for the metering device and / or a connecting line of the metering device such as a supply line or a discharge line is used.
- an air-permeable supply hose for example, which connects the metering device to the reservoir and thus precedes the metering, can create the possibility that the gas contained in the substance to be dispensed can be used together with the Substance is passed through this line, can escape, in the ideal case in the dosing unit no more gas inclusions in the substance.
- a seal such as a gasket, is provided on the metering device to seal the supply and discharge ports of the metering unit when this port is not connected to a supply or discharge line and, for example, to the metering unit from the connection to the supply line is turned to the connection with the discharge line.
- the metering device is preferably designed so that the maximum volume of the variable volume of the metering unit VOLz y ⁇ , n d e r, max, that is, for example, the volume of a cylinder at a nearly or fully withdrawn piston, smaller than 0.1 times Volume of the reservoir or a reservoir VOLR ese rvoir, in which the entire metered substance to be dispensed is included.
- the maximum volume of the dosing unit is greater than twice or even, for example, 10 times the volume of a minimum dose to be dispensed VOL o ose , mm.
- the maximum volume of the dosing unit is equal to the minimum volume of the dose to be dispensed multiplied by the root of the dosing unit Quotient formed from the volume of the reservoir and the minimum volume of the minimum dose to be delivered and thus satisfies the formula:
- VOL Zyhnder max VOL can min x V (VOL reservoir / VOLDose, min)
- the metering device is designed so that: 2 ... 10xV ⁇ l D ose, min ⁇ Volzyhnder. max ⁇ 1/10 ... 1/2 Vol R eserv Ol r
- the ratio of the inner diameter of a cylindrical metering unit to the cylinder length is equal to or about 1: 4.
- the invention relates to a method for dosing a substance to be dispensed from a reservoir or a reservoir, wherein the substance from the reservoir or reservoir via or through a single port or an opening in a variable-dose unit and in the case of As the volume increases, the connection or opening is connected to a discharge line after the metering or filling of the volume to be filled up, and the volume containing the substance is then reduced again in order to dispense the substance through the connection or opening ,
- the dosing unit is advantageously displaced or rotated with the substance to be dispensed, in order to decouple the opening of the dosing unit from the supply line and to connect it to the dispensing line.
- a metering device regardless of the formation and size of a reservoir or a reservoir, a precise dosage of the substance to be dispensed, wherein the metering unit in the case of using a single supply and discharge opening has a relatively small leakage or sealing risk.
- FIGS. 1A, B, C show a basic functional sequence during dosing with the dosing device
- Figure 2 shows an embodiment of the metering device
- FIG. 3 shows a cyclic process in an embodiment of the invention
- FIG. 4 shows a cyclic process in a further embodiment of the invention.
- FIG. 1A shows a metering device 1 with a cylinder 2, which has a single opening 2a on one end or bottom side.
- the opening 2a is connected to a feed line 4, which is connected to a not shown, for example, pressurized reservoir containing a metered substance to be dispensed, such as insulin.
- a movable piston 3 is arranged in the cylinder 2, which is arranged.
- FIG. 1B shows the metering device 1 according to FIG. 1A after the dosing unit 2, 3 has been retracted by retracting the piston 3 inside the cylinder 2, whereby a metered substance to be dispensed is introduced into the variable volume 6 of the cylinder 2 through the supply line 4.
- the cylinder 2 has already been rotated a part about its longitudinal axis after the completion of the filling, as indicated by the arrow, so that the opening 2a of the cylinder 2 is no longer connected to the supply line 4 or in fluid communication with this stands.
- the opening 2a has been moved or rotated in the state shown in Figure IB in the direction of the discharge line 5, wherein in the intermediate state shown in Figure 1 B, the opening 2a is closed by means of a voltage applied to the cylinder 2 seal 7.
- the cylinder 2 If the cylinder 2 is rotated so far until the opening 2a abuts the discharge line 5, as shown in Figure IC, by pushing the piston 3 into the cylinder 2, the metered substance contained in the volume 6 through the opening 2a to the discharge 5, which is connected to an infusion set or a needle, not shown. After partial or complete delivery of the substance contained in the variable volume 6 of the cylinder 2, the cylinder 2 can be rotated, for example, with the piston 3 fully inserted into the cylinder 2 so that the opening 2a rests against the supply line 4 again, as in FIG indicated by the state (4), so that the cycle shown in Figure 1 can be run through again.
- FIG. 2 shows an embodiment of the metering device according to the invention with a rotatable cylinder 2 made of plastic or of eg elastic material, which is arranged between two lines 4, 5, eg of elastic material and, for example, also within one Sealing sleeve is arranged with eg two openings.
- the variable volume 6 can be filled within the cylinder 2 by the retraction of the piston 3 with a metered substance to be dispensed, if provided on a side surface or the cylinder jacket opening 2a in connection with the supply line 4th is.
- the opening 2a may be a simple hole in the plastic cylinder 2, which closes by the elastic property of the material of the cylinder 2 and which allows passage of a substance only when a pressure or suction acts on the substance, such as by the withdrawal or insertion of the piston 3 in the cylinder. 2
- the dosing unit with the preferably in intermediate steps or gradually variable volume of the only supply and discharge connection is provided asymmetrically.
- these connections may be asymmetric.
- the connector (s) may also each be referred to as a simple opening in the dosing unit, such as a dosing unit. be provided a cylinder.
- the term "asymmetrical connection" or “asymmetric opening” is intended to mean such an opening in the dosing unit or e.g. a cylinder which changes its position during a movement, displacement or rotation of the dosing unit about an axis of symmetry.
- An asymmetrical opening may e.g.
- the asymmetric opening may be e.g. be provided temporally at the metering unit or in the cylinder jacket.
- the cylinder 2 After the metering of the cylinder 2, in which a substance passes through the supply line 4 through the lateral opening 2a in the cylinder 2, the cylinder 2 is rotated so in the embodiment by 180 degrees about its longitudinal axis, that the only opening 2a of the cylinder. 2 in connection in the derivative 5 stands. In this state, the piston 3 can be pushed back into the cylinder 2 to thereby displace the substance contained in the cylinder 2 and to discharge through the open self-closing opening 2a of the cylinder 2 to the drain 5, which is connected to an infusion set, not shown is. Subsequently, the cylinder 2 can be turned back again or further rotated until the lateral opening 2a of the cylinder 2 is again in fluid communication with the supply line 4, to receive again a dosed substance to be dispensed by the supply line 4.
- FIG. 3 shows a cyclic process which illustrates a functional sequence during dosing with an embodiment of the dosing device according to the invention.
- an initial state designated A in which the cylinder 2 is empty and the piston 3 is almost completely or completely retracted into the cylinder 2 in the direction of the opening 2a on the cylinder front side
- the cylinder 2 through the supply line 4, which is permeable to air is formed, gradually filled, as shown in Figure 3B, wherein the piston 3 is moved in the direction shown by the arrow within the cylinder 2 so that the variable volume 6 increases, whereby in the cylinder 2, a negative pressure can be generated, whereby the substance to be supplied from a reservoir (not shown) is sucked through the supply line 4 or introduced into the cylinder 2.
- the cylinder 2 or the opening 2a is positioned or rotated so that it lies as possible before the opening of the supply line 4, so that a fluid connection is created from the supply line 4 to the variable volume 6 through the opening 2a.
- sealing elements 7 At the front or the connection or contact side of the supply line 4 and the discharge line 5 with the cylinder 2 are in the embodiment shown sealing elements 7 and
- the seals 7 and 8 may e.g. consist of disc-shaped or annular elements, as shown in Figure 31, which are formed for example by an elastic material, wherein the cylinder 2 or an end face of the
- Cylinder 2 preferably can easily slide over the sealing elements 7 and 8.
- the cylinder 2 is in the completely filled state when the piston 3 has been pulled out to a maximum position, this maximum volume of the metering unit being designated VOLzyiin de r, max.
- the cylinder 2 is rotated about its longitudinal axis, as shown in Figure 3 D, to switch from the filling process of the cylinder 2 to the dispensing operation.
- the rotation of the cylinder 2 is carried out until the opening 2a on the discharge line 5, as shown in Figure 3 E, so that a fluid connection between the variable volume 6 of the cylinder 2 and the discharge line 5 is made through the opening 2a.
- the dosing unit can be switched over again in order to replenish the variable volume 6 after the dispensing operation has been completed.
- To switch the dosing of the cylinder 2 is again rotated so that the opening 2a is again in front of the supply line 4, as shown in Figure 3 A.
- the reciprocating or moving of the cylinder 2 as shown in Figures 3D and 3H can be accomplished both by rotation in the same direction, e.g. relative to the longitudinal axis of the cylinder always in a clockwise or always counterclockwise, done.
- the cylinder 2 it is also possible for the cylinder 2 to switch from a refilling operation to the dispensing operation, as shown in Fig. 3D, in a first direction, e.g. to the left, and to switch from the dispensing operation to the refilling operation, as shown in Fig. 3H, in the opposite direction, e.g. to the right, is turned.
- This is particularly advantageous when a reciprocating motion of the plug 3 is to be realized with a single motor, wherein the motor is also used for reciprocating or rotating the cylinder 2.
- FIG. 31 shows a perspective view of a sealing element 7, 8 with the passage opening 7a or 8a arranged therein, to which the supply line 4 in the states according to FIGS. 3A to 3C or the discharge line 5 in the states according to FIGS. 3E to 3G adjoin.
- FIG. 4 shows a further embodiment of the invention, wherein the functional sequence is similar to that in FIG. 3 and a cylinder 2 has openings 2a and 2b at its end face serving for filling and dispensing, which openings refer to a center point of FIG End face of the cylinder 2 can be arranged opposite to each other.
- a sealing element 7 is arranged, in which a through opening 7a is provided; see Fig. 41.
- the sealing element 7 is relative to the cylinder 2 and the supply line 4, and the discharge line 5, rotatable or movable.
- the cylinder 2, the supply line 4 and the discharge line 5 are in a defined or fixed positional relationship.
- the opening 7a of the sealing element 7 is in a position in which fluid communication between the supply line 4 and the variable volume 6 can be established.
- the sealing member 7 is rotated about its center axis M as shown in Fig. 4D until the opening 7a of the sealing member 7 is arranged to close the supply opening 2a of the cylinder 2 and the discharge opening 2b of the cylinder is fluidically coupled to the dispensing line 5 to perform the dispensing operation shown in Figs. 4E, 4F and 4G.
- FIG. 41 shows a perspective view of the sealing element 7 with a passage or passage piece 7a offset from the center point or pivot point M of the sealing element 7 in the radial direction.
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- General Physics & Mathematics (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL15165236T PL3012600T3 (pl) | 2007-03-15 | 2008-02-26 | Urządzenie dozujące dla systemu infuzyjnego |
EP17179898.6A EP3258223A1 (fr) | 2007-03-15 | 2008-02-26 | Dispositif de dosage pour un système d'infusion |
DK15165236.9T DK3012600T3 (en) | 2007-03-15 | 2008-02-26 | Dosage device for an infusion system |
EP15165236.9A EP3012600B1 (fr) | 2007-03-15 | 2008-02-26 | Dispositif de dosage pour un système d'infusion |
EP08716055A EP2118624A1 (fr) | 2007-03-15 | 2008-02-26 | Dispositif de dosage pour un système de perfusion |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07104240A EP1970677B1 (fr) | 2007-03-15 | 2007-03-15 | Système d'infusion avec dispositif de dosage |
PCT/EP2008/001516 WO2008110263A1 (fr) | 2007-03-15 | 2008-02-26 | Dispositif de dosage pour un système de perfusion |
EP08716055A EP2118624A1 (fr) | 2007-03-15 | 2008-02-26 | Dispositif de dosage pour un système de perfusion |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP15165236.9A Division EP3012600B1 (fr) | 2007-03-15 | 2008-02-26 | Dispositif de dosage pour un système d'infusion |
EP17179898.6A Division EP3258223A1 (fr) | 2007-03-15 | 2008-02-26 | Dispositif de dosage pour un système d'infusion |
Publications (1)
Publication Number | Publication Date |
---|---|
EP2118624A1 true EP2118624A1 (fr) | 2009-11-18 |
Family
ID=38375237
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07104240A Active EP1970677B1 (fr) | 2007-03-15 | 2007-03-15 | Système d'infusion avec dispositif de dosage |
EP15165236.9A Active EP3012600B1 (fr) | 2007-03-15 | 2008-02-26 | Dispositif de dosage pour un système d'infusion |
EP17179898.6A Pending EP3258223A1 (fr) | 2007-03-15 | 2008-02-26 | Dispositif de dosage pour un système d'infusion |
EP08716055A Ceased EP2118624A1 (fr) | 2007-03-15 | 2008-02-26 | Dispositif de dosage pour un système de perfusion |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07104240A Active EP1970677B1 (fr) | 2007-03-15 | 2007-03-15 | Système d'infusion avec dispositif de dosage |
EP15165236.9A Active EP3012600B1 (fr) | 2007-03-15 | 2008-02-26 | Dispositif de dosage pour un système d'infusion |
EP17179898.6A Pending EP3258223A1 (fr) | 2007-03-15 | 2008-02-26 | Dispositif de dosage pour un système d'infusion |
Country Status (10)
Country | Link |
---|---|
US (8) | US7955302B2 (fr) |
EP (4) | EP1970677B1 (fr) |
CN (1) | CN101652639B (fr) |
AT (1) | ATE445145T1 (fr) |
DE (1) | DE502007001678D1 (fr) |
DK (2) | DK1970677T3 (fr) |
ES (1) | ES2331546T3 (fr) |
HK (1) | HK1139457A1 (fr) |
PL (1) | PL3012600T3 (fr) |
WO (1) | WO2008110263A1 (fr) |
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WO2013029999A1 (fr) | 2011-09-02 | 2013-03-07 | F. Hoffmann-La Roche Ag | Module doseur pour dispositif de perfusion ambulatoire |
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-
2007
- 2007-03-15 DE DE502007001678T patent/DE502007001678D1/de active Active
- 2007-03-15 EP EP07104240A patent/EP1970677B1/fr active Active
- 2007-03-15 DK DK07104240.2T patent/DK1970677T3/da active
- 2007-03-15 ES ES07104240T patent/ES2331546T3/es active Active
- 2007-03-15 AT AT07104240T patent/ATE445145T1/de active
-
2008
- 2008-02-26 EP EP15165236.9A patent/EP3012600B1/fr active Active
- 2008-02-26 EP EP17179898.6A patent/EP3258223A1/fr active Pending
- 2008-02-26 PL PL15165236T patent/PL3012600T3/pl unknown
- 2008-02-26 DK DK15165236.9T patent/DK3012600T3/en active
- 2008-02-26 CN CN2008800085407A patent/CN101652639B/zh active Active
- 2008-02-26 EP EP08716055A patent/EP2118624A1/fr not_active Ceased
- 2008-02-26 WO PCT/EP2008/001516 patent/WO2008110263A1/fr active Application Filing
-
2009
- 2009-09-15 US US12/559,851 patent/US7955302B2/en active Active
-
2010
- 2010-05-31 HK HK10105332.4A patent/HK1139457A1/xx not_active IP Right Cessation
-
2011
- 2011-04-29 US US13/097,880 patent/US8277423B2/en active Active
- 2011-04-29 US US13/097,894 patent/US8277434B2/en active Active
-
2012
- 2012-08-17 US US13/588,042 patent/US8790316B2/en active Active
-
2014
- 2014-06-18 US US14/308,006 patent/US9687604B2/en active Active
-
2016
- 2016-12-02 US US15/367,580 patent/US10029046B2/en active Active
- 2016-12-20 US US15/384,880 patent/US10034983B2/en active Active
- 2016-12-21 US US15/386,026 patent/US10034977B2/en active Active
Non-Patent Citations (1)
Title |
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See references of WO2008110263A1 * |
Also Published As
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---|---|
US20120310163A1 (en) | 2012-12-06 |
US20170100537A1 (en) | 2017-04-13 |
US20100049127A1 (en) | 2010-02-25 |
US20110208154A1 (en) | 2011-08-25 |
EP3012600B1 (fr) | 2017-12-20 |
US8277434B2 (en) | 2012-10-02 |
DE502007001678D1 (de) | 2009-11-19 |
US20170100546A1 (en) | 2017-04-13 |
US10029046B2 (en) | 2018-07-24 |
US8790316B2 (en) | 2014-07-29 |
EP3012600A1 (fr) | 2016-04-27 |
US10034977B2 (en) | 2018-07-31 |
WO2008110263A1 (fr) | 2008-09-18 |
US20140301868A1 (en) | 2014-10-09 |
ES2331546T3 (es) | 2010-01-07 |
US8277423B2 (en) | 2012-10-02 |
US20170080150A1 (en) | 2017-03-23 |
PL3012600T3 (pl) | 2018-05-30 |
HK1139457A1 (en) | 2010-09-17 |
ATE445145T1 (de) | 2009-10-15 |
DK1970677T3 (da) | 2010-02-15 |
US7955302B2 (en) | 2011-06-07 |
DK3012600T3 (en) | 2018-03-26 |
CN101652639B (zh) | 2011-09-14 |
US20110208127A1 (en) | 2011-08-25 |
EP1970677B1 (fr) | 2009-10-07 |
US10034983B2 (en) | 2018-07-31 |
US9687604B2 (en) | 2017-06-27 |
CN101652639A (zh) | 2010-02-17 |
EP1970677A1 (fr) | 2008-09-17 |
EP3258223A1 (fr) | 2017-12-20 |
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