EP2056805B1 - Use of 2, 5-dihydroxybenzene derivatives for the treatment of tissue reactive diseases - Google Patents

Use of 2, 5-dihydroxybenzene derivatives for the treatment of tissue reactive diseases Download PDF

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Publication number
EP2056805B1
EP2056805B1 EP07788436A EP07788436A EP2056805B1 EP 2056805 B1 EP2056805 B1 EP 2056805B1 EP 07788436 A EP07788436 A EP 07788436A EP 07788436 A EP07788436 A EP 07788436A EP 2056805 B1 EP2056805 B1 EP 2056805B1
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EP
European Patent Office
Prior art keywords
acetyloxy
acid
disease
compound
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP07788436A
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German (de)
English (en)
French (fr)
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EP2056805A1 (en
Inventor
Pedro CUEVAS SÁNCHEZ
Iñigo SÁENZ DE TEJADA GORMAN
Guillermo GIMÉNEZ GALLEGO
Javier Angulo Frutos
Luis Ignacio RIVAS LÓPEZ
Francisco Javier Moreno Nuncio
Tomás Fernando FERNÁNDEZ JAEN
Rosa María LOZANO PUERTO
Antonio Romero Garrido
Serafín VALVERDE LÓPEZ
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Action Medicines SL
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Action Medicines SL
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Priority claimed from ES200602217A external-priority patent/ES2315117B1/es
Application filed by Action Medicines SL filed Critical Action Medicines SL
Publication of EP2056805A1 publication Critical patent/EP2056805A1/en
Application granted granted Critical
Publication of EP2056805B1 publication Critical patent/EP2056805B1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • Crohn's disease is an autoimmune chronic disease producing intestinal inflammation. Even if it may affect the whole gastrointestinal tract, most frequently it affects the ileum.
  • treatment may be continued until at least a 10 % improvement is effected in a symptom associated with the condition.
  • treatment is continued until the subject in need of such treatment experiences an improvement of at least about 20 %, at least about 30 %, at least about 40 %, preferably at least about 50 %, preferably at least about 60 %, more preferably at least about 70 %, more preferably at least about 80 %, even more preferably 90 % or greater in a symptom associated with a disorder described herein.
  • the compound used in the invention is administered at least once per week. In other embodiments, the compound is administered at least once per day. In yet other embodiments, the compound is administered twice per day. In another particular embodiment, the compound is administered over a period of at least about one week. In other embodiments, the compound is administered over a period of at least about four weeks.

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP07788436A 2006-08-16 2007-08-15 Use of 2, 5-dihydroxybenzene derivatives for the treatment of tissue reactive diseases Active EP2056805B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES200602217A ES2315117B1 (es) 2006-08-16 2006-08-16 Uso de derivados 2,5-dihidroxibencenicos en la preparacion de medicamentos utiles en el tratamiento de asma.
ES200701855 2007-07-02
PCT/EP2007/058456 WO2008020042A1 (en) 2006-08-16 2007-08-15 Use of 2, 5-dihydroxybenzene derivatives for the treatment of tissue reactive diseases

Publications (2)

Publication Number Publication Date
EP2056805A1 EP2056805A1 (en) 2009-05-13
EP2056805B1 true EP2056805B1 (en) 2011-05-25

Family

ID=38515369

Family Applications (3)

Application Number Title Priority Date Filing Date
EP07788431A Active EP2054045B1 (en) 2006-08-16 2007-08-15 Use of 2,5-dihydroxybenzene derivatives for the treatment of arthritis and pain
EP07788436A Active EP2056805B1 (en) 2006-08-16 2007-08-15 Use of 2, 5-dihydroxybenzene derivatives for the treatment of tissue reactive diseases
EP07802616.8A Active EP2056804B1 (en) 2006-08-16 2007-08-15 Use of 2,5-dihydroxybenzene derivatives for the treatment of ocular diseases

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP07788431A Active EP2054045B1 (en) 2006-08-16 2007-08-15 Use of 2,5-dihydroxybenzene derivatives for the treatment of arthritis and pain

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP07802616.8A Active EP2056804B1 (en) 2006-08-16 2007-08-15 Use of 2,5-dihydroxybenzene derivatives for the treatment of ocular diseases

Country Status (8)

Country Link
US (2) US20080114063A1 (pt)
EP (3) EP2054045B1 (pt)
AR (5) AR062399A1 (pt)
AT (2) ATE510536T1 (pt)
CL (5) CL2007002385A1 (pt)
ES (1) ES2495965T3 (pt)
PT (3) PT2054045E (pt)
WO (5) WO2008020031A1 (pt)

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US20080125485A1 (en) 2004-02-17 2008-05-29 Action Medicines Use of 2,5-Dihydroxybenzene Derivatives for Treating Actinic Keratosis
ES2238924B1 (es) * 2004-02-17 2006-12-01 Investread Europa, S.L. Uso del acido 2,5-dihidroxibencenosulfonico, en la fabricacion de medicamentos de aplicacion en el tratamiento de enfermedades angiodependientes.
US8541467B2 (en) 2006-08-16 2013-09-24 Action Medicines, S.L. Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of hematological dyscrasias and cancer of an organ
WO2009103069A1 (en) 2008-02-15 2009-08-20 Osborne David W Skin penetration enhancing systems for polar drugs
FR2951085B1 (fr) * 2009-10-09 2012-05-18 Inst Substances Vegetales Utilisation de composes phenoliques pour la deglycation des proteines
ES2385160B1 (es) * 2010-12-23 2013-05-24 Italfármaco, S.A. Compuestos con actividad inhibitoria de factores de crecimiento de fibroblastos.
ES2632012T3 (es) * 2012-02-02 2017-09-07 Invesfovea S.L. Uso del ácido 2,5-dihidroxibenceno sulfonato para el tratamiento de la degeneración macular relacionada con la edad
PL404138A1 (pl) * 2013-05-31 2014-12-08 Warszawski Uniwersytet Medyczny Pochodne kwasu benzoesowego jako inhibitory receptora IL-15Rα
PT3167881T (pt) * 2015-10-19 2019-12-05 Dobecure S L Etamsilato administrado localmente como medicamento

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Also Published As

Publication number Publication date
AR062396A1 (es) 2008-11-05
WO2008020033A1 (en) 2008-02-21
US9060966B2 (en) 2015-06-23
PT2054045E (pt) 2011-08-31
CL2007002385A1 (es) 2008-01-18
ATE510536T1 (de) 2011-06-15
US20080114063A1 (en) 2008-05-15
EP2054045B1 (en) 2011-05-18
EP2056804B1 (en) 2013-05-22
AR062395A1 (es) 2008-11-05
WO2008020034A1 (en) 2008-02-21
AR062393A1 (es) 2008-11-05
WO2008020032A8 (en) 2008-04-17
CL2007002388A1 (es) 2008-01-18
WO2008020042A1 (en) 2008-02-21
WO2008020031A1 (en) 2008-02-21
EP2056805A1 (en) 2009-05-13
PT2056805E (pt) 2011-09-02
ES2495965T3 (es) 2014-09-17
WO2008020032A1 (en) 2008-02-21
ATE509621T1 (de) 2011-06-15
EP2056804A1 (en) 2009-05-13
CL2007002387A1 (es) 2008-01-18
AR062390A1 (es) 2008-11-05
PT2056804E (pt) 2014-07-11
CL2007002386A1 (es) 2008-01-18
EP2054045A1 (en) 2009-05-06
US20110152222A1 (en) 2011-06-23
CL2007002392A1 (es) 2008-01-18
AR062399A1 (es) 2008-11-05

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RIN1 Information on inventor provided before grant (corrected)

Inventor name: ANGULO FRUTOS, JAVIER

Inventor name: FERNANDEZ JAEN, TOMAS FERNANDO

Inventor name: ROMERO GARRIDO, ANTONIO

Inventor name: GIMENEZ GALLEGO, GUILLERMO

Inventor name: MORENO NUNCIO, FRANCISCO JAVIER

Inventor name: LOZANO PUERTO, ROSA MARIA

Inventor name: VALVERDE LOPEZ, SERAFIN

Inventor name: RIVAS LOPEZ, LUIS IGNACIO

Inventor name: CUEVAS SANCHEZ, PEDRO

Inventor name: SAENZ DE TEJADA GORMAN, INIGO

RIN1 Information on inventor provided before grant (corrected)

Inventor name: VALVERDE LOPEZ, SERAFIN

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