EP2024253A1 - Sealed arrangement comprising a flow-limiting device, for the storage and dispensing of solid pharmaceutical products - Google Patents
Sealed arrangement comprising a flow-limiting device, for the storage and dispensing of solid pharmaceutical productsInfo
- Publication number
- EP2024253A1 EP2024253A1 EP07731467A EP07731467A EP2024253A1 EP 2024253 A1 EP2024253 A1 EP 2024253A1 EP 07731467 A EP07731467 A EP 07731467A EP 07731467 A EP07731467 A EP 07731467A EP 2024253 A1 EP2024253 A1 EP 2024253A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- storage
- container
- neck
- distribution according
- peripheral surface
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/04—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, or spherical or like small articles, e.g. tablets or pills
- B65D83/0481—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, or spherical or like small articles, e.g. tablets or pills the articles passing through a small opening or passage, without additional dispensing devices and without retaining means for the following article
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D51/00—Closures not otherwise provided for
- B65D51/18—Arrangements of closures with protective outer cap-like covers or of two or more co-operating closures
- B65D51/185—Arrangements of closures with protective outer cap-like covers or of two or more co-operating closures the outer closure being a foil membrane
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2251/00—Details relating to container closures
- B65D2251/0003—Two or more closures
- B65D2251/0006—Upper closure
- B65D2251/0031—Membrane
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2251/00—Details relating to container closures
- B65D2251/0003—Two or more closures
- B65D2251/0068—Lower closure
- B65D2251/009—Lower closure of the 51-type
Definitions
- the invention relates to a set of storage and controlled distribution of solid products, packaged in bulk, to be preferentially distributed to the unit, the tamper and sealing before first opening are provided by a cover.
- the invention relates to a set of storage and controlled distribution of solid products packaged in bulk, to be preferentially distributed to the unit, comprising a container such as for example a bottle, a flow limiter device inserted into the neck of the container. , a seal of tamper and sealing before first opening and a means of closing the assembly.
- a container such as for example a bottle
- a flow limiter device inserted into the neck of the container.
- a seal of tamper and sealing before first opening and a means of closing the assembly are, for example, pharmaceutical products, such as tablets, dragees, pills, tablets, lozenges, granules, capsules, capsules, of all shapes and the largest dimension of which is either the diameter or the length .
- Such a set of storage and distribution is intended to prevent the untimely exit of several products at a time, when using such a packaging by the end user, consumer of said products.
- EP 756567 discloses a package for medicaments, equipped with a dispensing system of said drugs in a compressed form.
- Such a container for tablets comprises a storage compartment that can contain a certain volume of tablets, said storage compartment being in communication with the outside of the container, via a dispensing device and this, by one or more passes dispensing system having one or more dispensing openings.
- This dispensing device may be formed to form an integral part of the container body or on the contrary be considered as an adapter separate from the container, and coming to attach to the container body to form the package.
- said adapter may include a compartment operating as a storage chamber of a generally powdery desiccant, thus protecting the tablets contained in the package against the ambient humidity of said package.
- a moisture porous membrane retains the powdery desiccant while allowing the moisture contained in the tablets stored in the container body and / or the internal moisture present in the container to be absorbed into the desiccant material .
- the container equipped with its dispensing device which can be considered as a flow limiter, is closed through a lid cap.
- the container and its lid cap are then designed in a joint manner, adapting to each other but independently of the dispensing device.
- the sealing of a peelable foil seal is a well-known technique, easy to implement and offers advantages such as rapid temperature rise, control, sealing temperatures, subject to the use of thermoplastic coatings on the aluminum seal having ability to adhere to the surface on which the seal is intended to be sealed.
- This sealing surface can be very different in nature, such as glass or plastic. Glass bottles are indeed very standard for the packaging of pharmaceutical products, offering transparency and high availability. However, other plastic materials can also be converted into containers, such as bottles or jars, by plastics technology such as injection blow molding or extrusion blow molding. These are often preferentially transparent materials such as polyesters or polycarbonates. Other materials are also possible such as polyethylenes or polypropylenes. The necks of these containers constitute the sealing surfaces.
- the flow restrictors of the prior art equipping containers such as flasks or jars can not give sufficiently satisfactory results in terms of their ability to integrate this lidding function via a sealable seal.
- the problem posed by the state of the art is, therefore, to achieve a set of storage and distribution of unitary solid products, packaged in bulk, equipped not only with a flow limiter dispenser and preferentially unit by unit distribution said products contained, but also means for sealing said assembly, permanently and sealed after filling via a thermally sealed lid.
- the invention relates to a set of storage and controlled distribution of unit products, consisting of a bulk storage container of said products, a container closure means and a distribution flow limiter device products having an upper surface and a lower surface, a device comprising, to allow the passage of products to be dispensed from the inside to the outside of the container: an inlet opening on its lower surface;
- the flow restrictor device a) is inserted into the container such that at least a portion of its upper surface is flush with the upper peripheral surface of the neck of the container forming a sealing plane or is supported by the peripheral surface of said neck via a support means whose upper surface forms a sealing plane; b) comprises, associated with the container, a seal sealed on at least one of the sealing surfaces defined by: the upper peripheral surface of the neck of the container; and / or all or part of the upper surface of the device; and / or the peripheral surface of the main dispensing orifice of the device.
- the invention finally relates to the use of the sealed storage and dispensing assembly for the packaging of solid products, more particularly of the pharmaceutical type.
- the storage and distribution assembly is in the form of a container, a flow-limiting device, having an upper surface and a lower surface and a peripheral surface between the two surfaces, an orifice dispensing device, the device being inserted into the neck of the container with which it is associated, together the inviolability and the sealing are ensured by a seal, then whose sealing is ensured, after first opening, by a closure means such as for example a cap / cover closable.
- the upper surface of the device may be flat, or formed of several parallel planes interconnected, or be concave or convex.
- the seal is sealed on at least one of the sealing surfaces which must be substantially flat and substantially level, that is to say at best in the same plane.
- the upper peripheral surface of the container neck generates a first plane which constitutes the first sealing surface.
- At least a substantially flat portion of the upper surface of the device and more preferably the upper peripheral surface of the device generates a second plane which constitutes the second sealing surface.
- the substantially planar peripheral surface of the main dispensing orifice generates a third plane which may constitute a third sealing surface.
- At least part of the upper surface of said device at most is flush with the upper peripheral surface of the neck of the container or is supported on this peripheral surface of said neck via the support means which may be a collar.
- the flow limiter device comprises an inlet opening located on its lower surface, at least one guide surface, with an axis of symmetry or not, the surface of which can be developable or non-developable and an outlet opening which opens on the main distribution orifice or which constitutes the main dispensing orifice, this device having a fixing means on the associated container.
- the flow-limiting device belonging to the assembly according to the invention can be architecturally massive, such as for example in the form of a solid plug or in the form of a thin-walled structure. both can be obtained by the techniques of the plastics industry.
- This flow limiter device also comprises, in the case of a massive architecture, an outer peripheral surface, preferably cylindrical or in the case of a thin-walled structure, a peripheral skirt, preferably cylindrical, surface or skirt on which is placed the fixing means for assembling the device to the container permanently and tightly.
- This flow limiter device comprises a continuous upper surface in the case of a massive architecture or an upper surface formed of parallel planes interconnected, appearing as concentric surfaces separated from each other and preferably as concentric rings in the in the case of a thin-walled architecture or a concave or convex upper surface, all these surfaces having the capacity to receive a peelable, heat-sealable, preferably induction-induced, operculum disposed over all or part of these surfaces and possibly overflowing from said surfaces to it can be sealed on the neck of the container and conceal the controlled storage and distribution assembly in a sealed manner.
- the flow limiter device belonging to the storage and distribution assembly has an inlet opening on its lower surface opening on the guide surface.
- Said inlet opening may be, for example, of circular, elliptical or polygonal section depending on the section of the container. However, it is preferentially circular, for reasons of simplicity of machining. This section is at most equal to the internal section of the neck of the container.
- the flow limiter device belonging to the storage and distribution assembly comprises a guide surface of the products to be dispensed, upstream of the main distribution orifice.
- the guide surface is in the form of a wall delimiting a hollow volume with spherical surface such as cap or spherical zone, frustoconical, cylindro-frustoconical, parabolic truncated, truncated hyperbolic, these surfaces being concave, of straight or oblique revolution, that is to say generated by a rectilinear line or by a curvilinear line.
- the hollow volume thus defined has a height and a base whose ratio between the height and the dimension of its base can be very low or even zero in the extreme case of a planar guide surface.
- the apex angle of the cone may be between 30 ° and 180 ° and preferably between 45 ° and 135 °.
- the wall-forming guide surface is open at both ends.
- One of the openings, the largest, is oriented towards the inside of the container and constitutes the input of the device for the products to be dispensed.
- the other opening opens onto or constitutes the main orifice for distribution and flow limitation of said products, because of its geometry created specifically.
- the guide surface may be a flat surface having the main dispensing orifice.
- Main Distribution Hole
- the storage and distribution assembly comprises a main distribution orifice on the upper surface of the flow restrictor device, allowing the passage, from inside to outside of the container, unit by unit, of the products. to distribute.
- the guiding surface opens onto the main dispensing orifice of the device or constitutes, by its small open end, the main dispensing orifice.
- the main dispensing orifice may be of different sections, circular, elliptical or polygonal or have any other geometry depending on the shape and size of the products to be dispensed.
- This orifice has dimensions that allow the passage of a single product at a time.
- the main distribution orifice is circular, its diameter is generally close to the length or the diameter of the product to be dispensed.
- the main dispensing orifice may be placed at the level of the plane of the upper peripheral surface of the flow restricting device or may be set back, that is to say below the level of the plane formed by the upper peripheral surface of the device or in superstructure with respect to this same plane.
- the main distribution orifice is preferably positioned in the center, that is to say in the axis of the flow restricting device. But in other designs, the main dispensing orifice may be positioned outside the axis of symmetry of the device flow limiter, such as for example at the periphery or at any other point on the upper surface of the device.
- the main dispensing orifice defines a peripheral planar surface which generates the third plane which may be the third sealing surface, depending on the case.
- main dispensing orifice can be set back from the plane of the upper peripheral surface of the flow restrictor device, creates a free space between the upper peripheral surface of the device constituting the second sealing surface receiving the seal. and the peripheral flat surface of the main distribution port, which allows to associate with said orifice an additional tamper system or a child protection system.
- the flow limiter device belonging to the storage and distribution assembly also comprises a fixing means on the inner surface of the container and / or on the neck of the container with which it is associated.
- the fixing means is positioned on the outer peripheral surface of the device in the case of a massive architecture or on the peripheral skirt in the case of a thin-walled structure.
- Various fastening means may be envisaged such as, for example, press fitting, clipping with groove and ring, on one or the other of the surfaces in the presence, differential thermal shrinkage, screwing, latching and the like.
- the preferred fastening means is constituted by a press fit between the preferentially outer cylindrical surface of the flow restricting device and the preferentially inner cylindrical surface of the neck of the container, that is to say its neck.
- the function of said partial slot is to be able to close partially during the introduction of the flow limiter device into the neck of the container and then to return to its original position, once said device is positioned in the neck of the container, at the level of the associated groove and rod assembly.
- This at least one partial slot reinforces the reversible resilient deformation capacity of the flow restrictor device when it is introduced into the neck of the container.
- the two edges of this at least one partial slot have the ability to come closer when introducing the flow restrictor into the neck of the container.
- Said fastening means makes it possible to seal between the inside and outside of the container when the outer peripheral surface of said device is not cylindrical but has an olive-like bulge.
- This sealing arrangement is particularly desirable when the lidding is not performed on the peripheral surface of the neck of the container, but, for example when it is performed on the single main distribution orifice of the flow limiting device.
- the fixing means also comprises means for positioning the device vertically relative to the neck of the associated container, preventing the vertical movement of the latter once in place, particularly in the case of a press fit.
- Such means may be constituted for example by a collar abutting on the neck of the container or in a peripheral housing provided in the neck of the container.
- Such a collar prevents too deep penetration of the device into the neck of the container and ensures precise vertical positioning.
- Such means may also be constituted by a non-return abutment against undercut, positioned at the bottom surface of the device and preventing the device from leaving the neck of the container on which it is attached.
- This non-return stop may be in the form of a crown or ring segments providing a certain elasticity to be introduced, by deformation, inside the neck of the container, then relax and act as a non-return valve. - back by coming to rest on the base of the neck of the container.
- Such elasticity and recovery of shape are provided by the resilient material chosen to produce the device and by the architecture of this non-return stop.
- connecting means comprising fixing elements and positioning of the device relative to the neck of the container can be deployed concomitantly.
- the flow restrictor device inserted into the container that is to say associated with the container comprises a sealed seal, on at least one of the surfaces defined by:
- the seal is thermally sealed on the only upper peripheral surface of the neck of the container, and is positioned in the first plane constituting the first sealing surface.
- the flow restrictor device is inserted into the neck of the container so that at least a portion of its top surface at the most arase the neck of the container constituting the first sealing surface.
- a recess on a portion of the wall of the neck of the container may be provided, to allow the positioning of the device when it is provided with a flange type of support means, leaving part of the neck thickness still available for sealing the seal.
- This first configuration in which the lid is integral with the only upper peripheral surface of the neck of the container, applies both for a massive architecture as for a thin-walled architecture of the device.
- the lid is sealed both on the upper peripheral surface of the neck of the container, whether or not this neck has a recess, that is to say on the first sealing surface and on the upper peripheral surface of the device leveling the neck, that is to say on the second sealing surface, whether or not there is a flange abutting in the recess of the neck.
- the upper surface of the flow restricting device is between the outside diameter of the flange when it is present and the inside diameter of the main distribution orifice.
- the upper surface of the flow-limiting device is in the form of concentric surfaces formed by the flange, when this is present, and the main distribution orifice, when the latter is present.
- the plane of the upper surface of the device At least one of these concentric surfaces constitutes a sealing surface associated with the first sealing surface constituted by the neck of the container.
- the lid is sealed both on the upper peripheral surface of the neck of the container, whether or not this neck has an annular recess and on the upper surface of the device flushing the neck. or the flange when the device is provided and on the upper peripheral surface of the main dispensing orifice, that is to say on the third sealing surface, when flaring the neck of the container.
- the seal is sealed on the only upper surface of the device, whether massive architecture or thin-walled.
- the cover may be sealed on the single collar of the device or on the single peripheral surface of the device. the main dispensing orifice or both at the same time.
- the sealing surface consists of the sole upper peripheral surface of the collar, that is to say on the second sealing surface.
- a fourth configuration relating to a so-called thin-walled architecture and when the main distribution orifice is set back from the plane of the upper peripheral surface of the device, it can be closed by a seal sealed on the sole peripheral surface the main dispensing orifice, that is to say on the third sealing surface.
- the device belonging to the assembly according to the invention is of thin-walled architecture, and has a main dispensing orifice positioned recessed relative to the plane of the upper peripheral surface of the device, it thus releases a space between the main dispensing orifice and the seal once it is sealed, this seal constituting a first control inviolability regardless of the sealing configurations selected.
- This available space makes it possible to associate, at the level of the main distribution opening, a second inviolability indicator, produced by means of a tear-off membrane connected, on the one hand, to a gripping and traction ring and to on the other hand, around the main dispensing opening and thus obscuring the main dispensing orifice.
- the user can thus, at first, delaminate the sealed lid, then tear, by pulling on the ring, the tearable membrane, thus releasing the main distribution orifice.
- the device thus equipped with the tearable membrane and its gripping ring is made by injection and in mono-material.
- This available space also allows to associate, instead of the second inviolability indicator, always at the main distribution port, a child protection system.
- a child protection system is constituted by a partition membrane positioned above and just to the right of the main dispensing orifice and in almost contact with the upper edge of said orifice.
- This membrane is connected to the main dispensing orifice by a single elastic deformable point integral link, since monobloc with said device, injected in a single operation from resilient material.
- the partition membrane is also equipped with a gripping means, allowing the user to exert a force on said partition.
- the thermal sealing of the lid on the sealing surfaces is done by various known techniques including induction in particular.
- the user first removes, after peeling, the sealed lid, guaranteeing sealing and inviolability of the set of storage and distribution, then reverses the meaning of the whole by turning it over so that the stock of products at distribute is placed above the dispensing device and in contact with its guide surface.
- the products to be distributed successively come into contact with the guide surface, then with the main distribution orifice whose adapted size allows the passage preferably of a single product at a time.
- the flow restrictor device belonging to the storage and distribution assembly is manufactured preferentially by molding injection techniques from thermoplastic materials.
- Plastics can be used to form the device and include high and low density, free radical or linear polyethylenes, ethylene copolymers such as ethylenes vinyl acetate, ethylene ethyl acrylates, ethylene butyl acrylate maleic anhydride ethylenes, ethylenes-alpha olefins, whatever the methods of polymerization or graft modification, polypropylene homo and copolymers, polybutene-1, polyisobutylene. Polyolefins are for reasons of cost and ease of implementation preferentially chosen to achieve the device.
- polymeric materials may however be considered, such as polyvinyl chloride, vinyl chloride copolymers, polyvinylidene chlorides, polystyrenes, styrene copolymers, cellulose derivatives, polyamides, polycarbonates, poly-oxy-methylenes, polyethylene terephthalates, polybutylene terephthalates, copolyesters, polyphenylene oxide, poly (methyl methacrylate), acrylate copolymers, fluoropolymers, poly ( phenylene sulphide), poly-aryl sulphones, poly-aryl-ether-ketones, poly-ether-imides, polyimides, thermoplastic elastomers, polyurethanes, phenol resins, melamine resins, resins ureas, epoxy resins and unsaturated polyester resins.
- polyvinyl chloride vinyl chloride copolymers
- polyvinylidene chlorides polystyrenes
- Biodegradable polymeric materials on, for example, starch bases are also possible such as, for example, poly-lactic acid (PLA).
- PLA poly-lactic acid
- the polymer used to make the flow restrictor device may also contain one or more additives such as elastomers, fibers, blowing agents, additives such as stabilizing agents and dyes, slip agents, release agents, adhesion or dyeing agents. reinforced hooking, according to the imperatives of implementation.
- additives such as elastomers, fibers, blowing agents, additives such as stabilizing agents and dyes, slip agents, release agents, adhesion or dyeing agents. reinforced hooking, according to the imperatives of implementation.
- the device according to the invention can also be made of injectable materials formulated in such a way that that they are able to absorb different pollutants such as moisture, oxygen, odor and other possible pollutants.
- These thermoplastics are then themselves formulated with additives belonging to the group of moisture absorbers, oxygen absorbers, odor absorbers and / or emitters of volatile organic compounds olfactory. These formulated thermoplastics must, however, retain some resilience.
- the assembly consisting of a storage container and a dispensing flow limiter device, sealed according to the invention, can be equipped with a closure means of the open end of the body of said container, which can be any stopper / cover, designed to ensure a seal between the container body and the cap / lid once the sealable seal removed.
- the container When used on the packaging line, the container is pre-filled with the products to be dispensed before receiving the flow restricting device.
- the reason is the ease of filling, because of the large size of the opening of the container not yet restricted by the addition of the flow restrictor device.
- the container equipped with its flow limiter device is then permanently closed by the peelable sealable liner on the packaging line, then possibly closed by a resealable cap.
- the device belonging to the storage and distribution unit according to the invention may or may not be delivered to the conditioner with its peelable seal already sealed on all or part of its upper surface.
- the container previously filled with the products to be dispensed receives its flow limiting device, the assembly being closed by the peelable seal sealed by induction on the neck of the container so as to close, so sealed, said container.
- the container previously filled with the products to be dispensed receives its flow limiter device already equipped with its seal sealed on the upper face of said device; said peelable sealable liner is positioned to the right of the neck of the container and induction sealing is effected between the lid and the neck.
- the peelable sealable seal is thus secured to both the neck of the container and the upper face of the flow restrictor device.
- the peelability is carried out on both surfaces together, by traction and delamination of the deformable flexible seal consisting of an aluminum foil, however sufficiently resistant to tearing so as not to tear during this delamination.
- the container In a third mode of use, the container, previously filled with the products to be dispensed, receives its flow limiter device already equipped with its peelable seal sealingly sealed to the single main dispensing opening.
- the peelable operculum generally comprises an outer portion protruding from the annular surface sealed and prehensile by the user.
- An identical, unsealed portion on the upper outer surface of the flow restrictor device may also exist in the case of a lid serving only for sealing the single main distribution orifice of the flow limiting device according to the invention. .
- the flow limiter device can also be simply mounted on the container after filling, said container then receiving its cap, itself containing, in its bottom, sealable peelable seal, the maintenance of the cap being done by any type of clipping.
- the induction sealing of the lid is then performed through the plug thus mounted. According to the configurations, and as previously described, the sealing may be performed on the only edges of the neck, and / or all or part of the upper face of the device.
- Such a set of storage and distribution is used to distribute preferentially unit by unit a stock of products to be distributed stored stored in use and protected from the outside environment.
- FIG. 1 represents a sectional view of the sealed assembly comprising the storage container and the flow limiter device, of thin-walled architecture, according to the invention, associated with its container, at the neck of said container and whose lidding has been performed on the concentric surfaces only corresponding to the main dispensing orifice and the upper surface of the collar, as well as on the available surface of the neck of the container;
- FIG. 2 represents a cross-sectional view of the sealed assembly comprising the storage container and the massive structure flow limiter device, the peelable seal of which has been sealed by induction on the upper surface of the device and on the available portion of the device. container neck;
- FIG. 3 represents a cross-sectional view of the sealed assembly comprising the storage container and the thin-walled architectural flow limiter device according to the invention, associated with its container, at the neck of said container and sealed off on the only concentric surfaces corresponding to the upper surface of the collar, as well as on the available surface of the neck of the container, the main dispensing orifice being recessed and allowing the establishment of a double inviolability system;
- FIG. 4 represents a cross-sectional view of the assembly that is capped identically in FIG. 3, but whose double inviolability system has been replaced by a child safety system;
- FIG. 5 shows a sectional view of the sealed assembly comprising the storage container and the thin-walled architecture flow limiter device according to the invention associated with its container, at the neck of said container being sealed to only level of its main dispensing orifice by the peelable operculum;
- FIG. 6 represents a cross-sectional view of the sealed assembly comprising the storage container, partially shown, the thin-walled architectural flow limiter device according to the invention, whose guide surface is conical and is supported on a hemispherical surface and having a main distribution port centered and secondary openings opening on the main distribution port.
- FIG. 1 represents a cross-sectional view of the set (1) sealed with the storage container (2) and the flow limiter device (3) of thin-walled architecture, according to the invention, associated with its container, at the neck (4) of said container.
- This device is inserted into the neck of the container in such a way that at least part of its upper surface is flush with the peripheral surface of the neck of the container forming a sealing plane.
- the flow restrictor device (3) has an inlet opening (5) facing towards the inside of the container, a guide surface (6), an outlet opening (7) which opens onto the main dispensing orifice (8), this device also having a discontinuous outer surface (9, 10) having received a peelable seal (11), sealed by induction.
- the induction sealing of the peelable seal (11) is performed on the concentric upper surfaces (9 and 10) corresponding to the main dispensing orifice (8) and the upper surface of the collar (12) positioned at the upper end of the skirt (13), that is to say respectively on the second and third sealing surfaces and on the neck (4) of the container, constituting the first sealing surface.
- the peelable seal (11) sealable by induction can be sealed both on the sole sealing surface corresponding to the free annular zone of the neck of the container, that on both the upper surface of the flow restrictor device constituting the zones sealing (9 and 10) and on the sealing area of the neck (4) of the container.
- FIG. 2 represents a cross-sectional view of the set (1) sealed, comprising the storage container (2) and the flow-limiting device (3) with a solid structure whose peelable seal (11) is induction-sealed on the upper surface of the device, (9,10) and on the available portion of the neck (4) of the container (2).
- the device (3) is held in a non-return position by means of a peripheral protrusion (14) placed in the lower part of said device, constituting the specific means of attachment.
- the peelable seal (11) sealable by induction can be sealed both on the sole sealing surface corresponding to the free annular surface of the neck (4) of the container (2), which constitutes the first sealing surface, that on, to both, the upper surface of the device constituting a sealing surface (9, 10) and on the annular sealing surface of the neck (4) of the container (2).
- FIG. 3 shows a sectional view of the assembly (1) sealed comprising the storage container (2) and the flow limiter device (3) of thin-walled architecture, according to the invention.
- the induction seal of the peelable seal (11) is performed on the concentric surfaces corresponding to the upper peripheral surface of the device, that is to say on its collar (9), and on the peripheral upper surface of the neck ( 4) of the container, respectively representing the second surface and the first sealing surface.
- a tamper evidence in the form of a tear-off membrane (16) concealing the orifice and connected to a pull ring (17) which makes it possible to tear the diaphragm (16) and thereby open the main dispensing orifice ( 8).
- the device (3) is held in a non-return position by means of a peripheral protrusion (14) placed in the lower part of said device (3).
- FIG. 4 represents a sectional view of the set (1) sealed, comprising the storage container (2) and the thin-walled architecture flow limiter device (3), according to the invention, associated with its container ( 2), at the neck (4) of said container (2), in the same manner as in FIG. 3.
- Induction sealing of the peelable seal (11) is carried out in the same manner, that is, that is, on the only concentric surfaces corresponding to the upper peripheral surface of the collar (9) as well as on the upper peripheral surface of the neck (4) of the container.
- the system includes a partition membrane (18) positioned above the main delivery orifice (8) of the flow restrictor (3), and connected to said orifice (8) by a resilient integral link (19) and also equipped with a gripping means (20).
- the device (3) is held in a non-return position by means of a peripheral protrusion (14) placed in the lower part of said device (3).
- FIG. 5 represents a cross-sectional view of the operculum assembly (1) comprising the storage container (2) and the flow limiter device (3) of thin-walled architecture.
- the assembly (1) is sealed at only the level of the peripheral surface (10) of the main orifice of distribution (8), that is to say the third sealing surface, by the peelable seal (11).
- the device (3) belonging to the set (1) for storage and distribution comprises a main distribution orifice (8) preceded by at least one guide surface (6), with an axis of symmetry.
- said surface (6) having an inlet opening (5) which is the large inward facing base of the container and an outlet opening (7) which opens onto the main dispensing opening (8).
- the device belonging to the set (1) for storage and distribution comprises an outer peripheral surface (13) forming a skirt having a fastening means of force-fitting type with the neck (4) of the container ensuring the seal.
- the device belonging to the set (1) of storage and distribution comes to rest on the neck (4) of the container, through its flange (12).
- the force fitting between the outer peripheral surface of the device and the inner peripheral surface of the neck (4) of the container makes it possible to seal between the container (2) and the outside, once the main dispensing orifice (8) sealed by the induction sealable peelable seal (11) on the sealing surface (10).
- FIG. 6 represents a cross-sectional view of the sealed assembly (1) comprising the storage container (2), partially shown, the thin-walled architecture flow limiting device according to the invention, whose guiding surface ( 6) is frustoconical and builds on a hemispherical surface and having a main distribution port centered (8) and secondary openings opening on the main distribution port.
- the device belonging to the set (1) of storage and distribution is inserted into the neck (4) of the container.
- the force fitting between the outer peripheral surface of the device and the inner peripheral surface of the neck (4) of the container makes it possible to seal between the container (2) and the outside.
- the vertical positioning of the device relative to the neck (4) of the container is provided by the fastening means (13) consisting of two grooves formed in the container neck and in which are positioned two equivalent rods existing on the outer skirt of the container. device.
- the sealable peelable seal (11) is sealed to the sealing surface (10) formed by the upper annular edge of the neck (4) of the container, i.e. the first sealing surface.
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Closures For Containers (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0604538A FR2901253B1 (en) | 2006-05-19 | 2006-05-19 | OPERATED STORAGE AND DISPENSING ASSEMBLY WITH FLOW LIMITER OF SOLID PHARMACEUTICAL PRODUCTS |
PCT/FR2007/000831 WO2007135277A1 (en) | 2006-05-19 | 2007-05-16 | Sealed arrangement comprising a flow-limiting device, for the storage and dispensing of solid pharmaceutical products |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2024253A1 true EP2024253A1 (en) | 2009-02-18 |
EP2024253B1 EP2024253B1 (en) | 2009-10-07 |
Family
ID=37103345
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07731467A Active EP2024253B1 (en) | 2006-05-19 | 2007-05-16 | Sealed arrangement comprising a flow-limiting device, for the storage and dispensing of solid pharmaceutical products |
Country Status (5)
Country | Link |
---|---|
US (1) | US7780008B2 (en) |
EP (1) | EP2024253B1 (en) |
DE (1) | DE602007002713D1 (en) |
FR (1) | FR2901253B1 (en) |
WO (1) | WO2007135277A1 (en) |
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-
2007
- 2007-05-16 DE DE602007002713T patent/DE602007002713D1/en active Active
- 2007-05-16 WO PCT/FR2007/000831 patent/WO2007135277A1/en active Application Filing
- 2007-05-16 EP EP07731467A patent/EP2024253B1/en active Active
- 2007-05-21 US US11/751,280 patent/US7780008B2/en active Active
Non-Patent Citations (1)
Title |
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Also Published As
Publication number | Publication date |
---|---|
FR2901253A1 (en) | 2007-11-23 |
US7780008B2 (en) | 2010-08-24 |
FR2901253B1 (en) | 2008-08-15 |
WO2007135277A1 (en) | 2007-11-29 |
DE602007002713D1 (en) | 2009-11-19 |
EP2024253B1 (en) | 2009-10-07 |
US20070267304A1 (en) | 2007-11-22 |
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